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Aliases for RITA1 Gene

Aliases for RITA1 Gene

  • RBPJ Interacting And Tubulin Associated 1 2 3
  • C12orf52 3 4
  • RITA 3 4
  • RBPJ-Interacting And Tubulin-Associated Protein 1 3
  • RBPJ-Interacting And Tubulin-Associated Protein 4
  • RBP-J Interacting And Tubulin Associated 2
  • Chromosome 12 Open Reading Frame 52 2

External Ids for RITA1 Gene

Previous Symbols for RITA1 Gene

  • C12orf52

Summaries for RITA1 Gene

GeneCards Summary for RITA1 Gene

RITA1 (RBPJ Interacting And Tubulin Associated 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RITA1 Gene

  • Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RITA1 Gene

Genomics for RITA1 Gene

Genomic Location for RITA1 Gene

Start:
113,185,526 bp from pter
End:
113,192,368 bp from pter
Size:
6,843 bases
Orientation:
Plus strand

Genomic View for RITA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RITA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RITA1 Gene

No data available for Regulatory Elements for RITA1 Gene

Proteins for RITA1 Gene

  • Protein details for RITA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K30-RITA1_HUMAN
    Recommended name:
    RBPJ-interacting and tubulin-associated protein 1
    Protein Accession:
    Q96K30
    Secondary Accessions:
    • B3KVZ4
    • C9JIN1
    • F8VRG5
    • Q53GM3
    • Q96K25

    Protein attributes for RITA1 Gene

    Size:
    269 amino acids
    Molecular mass:
    28619 Da
    Quaternary structure:
    • Interacts with RBPJ/RBPSUH.

    Alternative splice isoforms for RITA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RITA1 Gene

Proteomics data for RITA1 Gene at MOPED

Post-translational modifications for RITA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RITA1 Gene

No data available for DME Specific Peptides for RITA1 Gene

Domains for RITA1 Gene

Protein Domains for RITA1 Gene

ProtoNet:

UniProtKB/Swiss-Prot:

RITA1_HUMAN
Family:
  • Belongs to the RITA family.:
    • Q96K30
genes like me logo Genes that share domains with RITA1: view

No data available for Gene Families for RITA1 Gene

Function for RITA1 Gene

Molecular function for RITA1 Gene

UniProtKB/Swiss-Prot Function: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Gene Ontology (GO) - Molecular Function for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21102556
GO:0015631 tubulin binding IDA 21102556
genes like me logo Genes that share ontologies with RITA1: view

miRNA for RITA1 Gene

miRTarBase miRNAs that target RITA1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RITA1 Gene

Localization for RITA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RITA1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.

Gene Ontology (GO) - Cellular Components for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21102556
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 21102556
GO:0005794 Golgi apparatus IDA --
GO:0005813 centrosome IDA 21102556
genes like me logo Genes that share ontologies with RITA1: view

Pathways for RITA1 Gene

SuperPathways for RITA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 21102556
GO:0007219 Notch signaling pathway IEA --
GO:0022008 neurogenesis ISS --
GO:0045746 negative regulation of Notch signaling pathway IDA 21102556
GO:0051168 nuclear export IDA 21102556
genes like me logo Genes that share ontologies with RITA1: view

No data available for Pathways by source for RITA1 Gene

Transcripts for RITA1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RITA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RITA1 Gene

GeneLoc Exon Structure for
RITA1
ECgene alternative splicing isoforms for
RITA1

Expression for RITA1 Gene

mRNA expression in normal human tissues for RITA1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RITA1 Gene

genes like me logo Genes that share expressions with RITA1: view

Orthologs for RITA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RITA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf52 36
  • 99.32 (n)
  • 98.63 (a)
RITA1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RITA 37
  • 75 (a)
OneToOne
RITA1 36
  • 81.16 (n)
  • 74.72 (a)
dog
(Canis familiaris)
Mammalia C26H12orf52 36
  • 83.7 (n)
  • 78.15 (a)
RITA1 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1110008J03Rik 16
1110008J03Rik 37
  • 68 (a)
OneToOne
Rita1 36
  • 74.97 (n)
  • 67.59 (a)
oppossum
(Monodelphis domestica)
Mammalia RITA1 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306772 36
  • 74.81 (n)
  • 66.67 (a)
lizard
(Anolis carolinensis)
Reptilia RITA1 37
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491156 36
  • 48.12 (n)
  • 43.05 (a)
Species with no ortholog for RITA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RITA1 Gene

ENSEMBL:
Gene Tree for RITA1 (if available)
TreeFam:
Gene Tree for RITA1 (if available)

Paralogs for RITA1 Gene

No data available for Paralogs for RITA1 Gene

Variants for RITA1 Gene

Sequence variations from dbSNP and Humsavar for RITA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1043845 -- 113,192,144(+) AACGG(C/T)GTGAT utr-variant-3-prime
rs7976460 -- 113,188,763(+) ccctt(A/G)taatg intron-variant
rs11066509 -- 113,187,681(+) gagcc(C/T)aggag intron-variant
rs11066510 -- 113,190,216(+) AATCC(C/T)GCCTA intron-variant
rs11503147 -- 113,188,737(+) CAGTT(C/T)TATTG intron-variant

Relevant External Links for RITA1 Gene

HapMap Linkage Disequilibrium report
RITA1

No data available for Structural Variations from Database of Genomic Variants (DGV) for RITA1 Gene

Disorders for RITA1 Gene

No disorders were found for RITA1 Gene.

No data available for UniProtKB/Swiss-Prot for RITA1 Gene

Publications for RITA1 Gene

  1. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. (PMID: 21102556) Wacker S.A. … Oswald F. (EMBO J. 2011) 2 3 4
  2. RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis. (PMID: 24308154) Wang H. … Liu C. (Oncol. Res. 2013) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RITA1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RITA1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RITA1
    • Block miRNA regulation of RITA1 using miScript Target Protectors

    Sources for RITA1 Gene

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