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Aliases for RITA1 Gene

Aliases for RITA1 Gene

  • RBPJ Interacting And Tubulin Associated 1 2 3 5
  • C12orf52 3 4
  • RITA 3 4
  • RBPJ-Interacting And Tubulin-Associated Protein 1 3
  • RBPJ-Interacting And Tubulin-Associated Protein 4
  • RBP-J Interacting And Tubulin Associated 2
  • Chromosome 12 Open Reading Frame 52 2

External Ids for RITA1 Gene

Previous HGNC Symbols for RITA1 Gene

  • C12orf52

Previous GeneCards Identifiers for RITA1 Gene

  • GC12P113624

Summaries for RITA1 Gene

GeneCards Summary for RITA1 Gene

RITA1 (RBPJ Interacting And Tubulin Associated 1) is a Protein Coding gene. GO annotations related to this gene include tubulin binding.

UniProtKB/Swiss-Prot for RITA1 Gene

  • Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Additional gene information for RITA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RITA1 Gene

Genomics for RITA1 Gene

Regulatory Elements for RITA1 Gene

Enhancers for RITA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H113226 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.2 +44.7 44730 8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 SLC30A9 ZNF766 ZNF143 RITA1 RBM19 DDX54 ENSG00000201208 IQCD TPCN1 DTX1 ENSG00000277566
GH12H113220 1.7 FANTOM5 ENCODE dbSUPER 24.2 +36.8 36832 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 RITA1 RBM19 ENSG00000257603 GLULP5 ENSG00000257997 RASAL1 DDX54 ENSG00000201208 TPCN1 IQCD
GH12H113235 1.6 Ensembl ENCODE dbSUPER 24.4 +56.9 56870 13 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 FOS RITA1 RASAL1 TPCN1 IQCD DDX54 ENSG00000201208 PLBD2 ENSG00000277566
GH12H113258 1.4 Ensembl ENCODE dbSUPER 22 +74.2 74214 2 ARID4B THRB RAD21 YY1 SCRT2 RCOR1 MIXL1 SP5 MXD4 REST RITA1 DDX54 ENSG00000201208 GC12M113256 ENSG00000277566
GH12H113069 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -114.7 -114692 2 FOXA2 TBL1XR1 INSM2 RAD21 RARA YY1 ZNF143 FOS ATF7 ETV6 ENSG00000201208 RITA1 DDX54 CFAP73 DTX1 PLBD2 SDSL GC12P113070 RASAL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RITA1 on UCSC Golden Path with GeneCards custom track

Promoters for RITA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057593 -326 2001 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for RITA1 Gene

Chromosome:
12
Start:
113,185,526 bp from pter
End:
113,192,368 bp from pter
Size:
6,843 bases
Orientation:
Plus strand

Genomic View for RITA1 Gene

Genes around RITA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RITA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RITA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RITA1 Gene

Proteins for RITA1 Gene

  • Protein details for RITA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K30-RITA1_HUMAN
    Recommended name:
    RBPJ-interacting and tubulin-associated protein 1
    Protein Accession:
    Q96K30
    Secondary Accessions:
    • B3KVZ4
    • C9JIN1
    • F8VRG5
    • Q53GM3
    • Q96K25

    Protein attributes for RITA1 Gene

    Size:
    269 amino acids
    Molecular mass:
    28619 Da
    Quaternary structure:
    • Interacts with RBPJ/RBPSUH.

    Three dimensional structures from OCA and Proteopedia for RITA1 Gene

    Alternative splice isoforms for RITA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RITA1 Gene

Post-translational modifications for RITA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RITA1 Gene

No data available for DME Specific Peptides for RITA1 Gene

Domains & Families for RITA1 Gene

Gene Families for RITA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RITA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96K30

UniProtKB/Swiss-Prot:

RITA1_HUMAN :
  • Belongs to the RITA family.
Family:
  • Belongs to the RITA family.
genes like me logo Genes that share domains with RITA1: view

No data available for Suggested Antigen Peptide Sequences for RITA1 Gene

Function for RITA1 Gene

Molecular function for RITA1 Gene

UniProtKB/Swiss-Prot Function:
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Gene Ontology (GO) - Molecular Function for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21102556
GO:0015631 tubulin binding IEA,IDA 21102556
genes like me logo Genes that share ontologies with RITA1: view

Phenotypes for RITA1 Gene

genes like me logo Genes that share phenotypes with RITA1: view

Animal Model Products

CRISPR Products

miRNA for RITA1 Gene

miRTarBase miRNAs that target RITA1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RITA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RITA1 Gene

Localization for RITA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RITA1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RITA1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
mitochondrion 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 21102556
GO:0005737 cytoplasm IDA,IEA 21102556
GO:0005813 centrosome IDA 21102556
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with RITA1: view

Pathways & Interactions for RITA1 Gene

SuperPathways for RITA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 21102556
GO:0007219 Notch signaling pathway IEA --
GO:0007399 nervous system development IEA --
GO:0022008 neurogenesis ISS --
GO:0045746 negative regulation of Notch signaling pathway IDA 21102556
genes like me logo Genes that share ontologies with RITA1: view

No data available for Pathways by source and SIGNOR curated interactions for RITA1 Gene

Drugs & Compounds for RITA1 Gene

No Compound Related Data Available

Transcripts for RITA1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RITA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RITA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RITA1 Gene

GeneLoc Exon Structure for
RITA1
ECgene alternative splicing isoforms for
RITA1

Expression for RITA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RITA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RITA1 Gene



Protein tissue co-expression partners for RITA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RITA1 Gene:

RITA1

Evidence on tissue expression from TISSUES for RITA1 Gene

  • Kidney(4.4)
  • Nervous system(4.3)
  • Gall bladder(2)
  • Intestine(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RITA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RITA1 Gene

Orthologs for RITA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RITA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf52 33
  • 99.32 (n)
RITA1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C26H12orf52 33
  • 83.7 (n)
RITA1 34
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RITA1 33
  • 81.16 (n)
RITA 34
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rita1 33 16
  • 74.97 (n)
1110008J03Rik 34
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306772 33
  • 74.81 (n)
oppossum
(Monodelphis domestica)
Mammalia RITA1 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RITA1 34
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491156 33
  • 48.12 (n)
Species where no ortholog for RITA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RITA1 Gene

ENSEMBL:
Gene Tree for RITA1 (if available)
TreeFam:
Gene Tree for RITA1 (if available)

Paralogs for RITA1 Gene

No data available for Paralogs for RITA1 Gene

Variants for RITA1 Gene

Sequence variations from dbSNP and Humsavar for RITA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000000451 -- 113,192,184(+) TTCAA(G/T)CCAAG utr-variant-3-prime
rs1000200284 -- 113,191,908(+) CCCCA(A/G)GTATT utr-variant-3-prime
rs1000295980 -- 113,185,426(+) GTCCA(C/G)CCGCC upstream-variant-2KB, reference, missense
rs1000714909 -- 113,190,096(+) AGGCC(A/G)AGGTG intron-variant
rs1000916684 -- 113,190,440(+) AGGAA(C/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RITA1 Gene

Variant ID Type Subtype PubMed ID
esv3630792 CNV gain 21293372
esv3892265 CNV gain 25118596
nsv519540 CNV gain+loss 19592680

Variation tolerance for RITA1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RITA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RITA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RITA1 Gene

Disorders for RITA1 Gene

Relevant External Links for RITA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RITA1

No disorders were found for RITA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RITA1 Gene

Publications for RITA1 Gene

  1. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. (PMID: 21102556) Wacker SA … Oswald F (The EMBO journal 2011) 2 3 4 60
  2. RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis. (PMID: 24308154) Wang H … Liu C (Oncology research 2013) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Structure-function analysis of RBPJ-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. (PMID: 28487372) Tabaja N … Kovall RA (The Journal of biological chemistry 2017) 3 60
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 60

Products for RITA1 Gene

Sources for RITA1 Gene

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