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Aliases for RITA1 Gene

Aliases for RITA1 Gene

  • RBPJ Interacting And Tubulin Associated 1 2 3 5
  • C12orf52 3 4
  • RITA 3 4
  • RBPJ-Interacting And Tubulin-Associated Protein 4
  • RBP-J Interacting And Tubulin Associated 2
  • Chromosome 12 Open Reading Frame 52 2

External Ids for RITA1 Gene

Previous HGNC Symbols for RITA1 Gene

  • C12orf52

Previous GeneCards Identifiers for RITA1 Gene

  • GC12P113624

Summaries for RITA1 Gene

GeneCards Summary for RITA1 Gene

RITA1 (RBPJ Interacting And Tubulin Associated 1) is a Protein Coding gene. GO annotations related to this gene include tubulin binding.

UniProtKB/Swiss-Prot for RITA1 Gene

  • Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RITA1 Gene

Genomics for RITA1 Gene

Regulatory Elements for RITA1 Gene

Promoters for RITA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RITA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RITA1 Gene

Chromosome:
12
Start:
113,185,526 bp from pter
End:
113,192,368 bp from pter
Size:
6,843 bases
Orientation:
Plus strand

Genomic View for RITA1 Gene

Genes around RITA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RITA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RITA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RITA1 Gene

Proteins for RITA1 Gene

  • Protein details for RITA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K30-RITA1_HUMAN
    Recommended name:
    RBPJ-interacting and tubulin-associated protein 1
    Protein Accession:
    Q96K30
    Secondary Accessions:
    • B3KVZ4
    • C9JIN1
    • F8VRG5
    • Q53GM3
    • Q96K25

    Protein attributes for RITA1 Gene

    Size:
    269 amino acids
    Molecular mass:
    28619 Da
    Quaternary structure:
    • Interacts with RBPJ/RBPSUH.

    Alternative splice isoforms for RITA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RITA1 Gene

Proteomics data for RITA1 Gene at MOPED

Post-translational modifications for RITA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RITA1 Gene

No data available for DME Specific Peptides for RITA1 Gene

Domains & Families for RITA1 Gene

Protein Domains for RITA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96K30

UniProtKB/Swiss-Prot:

RITA1_HUMAN :
  • Belongs to the RITA family.
Family:
  • Belongs to the RITA family.
genes like me logo Genes that share domains with RITA1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RITA1 Gene

Function for RITA1 Gene

Molecular function for RITA1 Gene

UniProtKB/Swiss-Prot Function:
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Phenotypes for RITA1 Gene

genes like me logo Genes that share phenotypes with RITA1: view

Animal Model Products

miRNA for RITA1 Gene

miRTarBase miRNAs that target RITA1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RITA1 Gene

Localization for RITA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RITA1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.

Gene Ontology (GO) - Cellular Components for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21102556
GO:0005737 cytoplasm IDA 21102556
genes like me logo Genes that share ontologies with RITA1: view

No data available for Subcellular locations from COMPARTMENTS for RITA1 Gene

Pathways & Interactions for RITA1 Gene

SuperPathways for RITA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0022008 neurogenesis ISS --
genes like me logo Genes that share ontologies with RITA1: view

No data available for Pathways by source and SIGNOR curated interactions for RITA1 Gene

Drugs & Compounds for RITA1 Gene

No Compound Related Data Available

Transcripts for RITA1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RITA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RITA1 Gene

GeneLoc Exon Structure for
RITA1
ECgene alternative splicing isoforms for
RITA1

Expression for RITA1 Gene

mRNA expression in normal human tissues for RITA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RITA1 Gene



genes like me logo Genes that share expression patterns with RITA1: view

Protein tissue co-expression partners for RITA1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RITA1 Gene

Orthologs for RITA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RITA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RITA1 35
  • 81.16 (n)
  • 74.72 (a)
RITA 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C26H12orf52 35
  • 83.7 (n)
  • 78.15 (a)
RITA1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rita1 35
  • 74.97 (n)
  • 67.59 (a)
Rita1 16
1110008J03Rik 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf52 35
  • 99.32 (n)
  • 98.63 (a)
RITA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1306772 35
  • 74.81 (n)
  • 66.67 (a)
oppossum
(Monodelphis domestica)
Mammalia RITA1 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RITA1 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491156 35
  • 48.12 (n)
  • 43.05 (a)
Species with no ortholog for RITA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RITA1 Gene

ENSEMBL:
Gene Tree for RITA1 (if available)
TreeFam:
Gene Tree for RITA1 (if available)

Paralogs for RITA1 Gene

No data available for Paralogs for RITA1 Gene

Variants for RITA1 Gene

Sequence variations from dbSNP and Humsavar for RITA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs34831139 - 113,191,666(+) CCACA(A/C)AAATG reference, missense
rs16942601 - 113,191,345(+) TGAGT(C/G/T)GCTGT reference, missense
rs1043845 -- 113,192,144(+) AACGG(C/T)GTGAT utr-variant-3-prime
rs7976460 -- 113,188,763(+) ccctt(A/G)taatg intron-variant
rs11066509 -- 113,187,681(+) gagcc(C/T)aggag intron-variant

Variation tolerance for RITA1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RITA1 Gene

HapMap Linkage Disequilibrium report
RITA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RITA1 Gene

Disorders for RITA1 Gene

Relevant External Links for RITA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RITA1

No disorders were found for RITA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RITA1 Gene

Publications for RITA1 Gene

  1. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. (PMID: 21102556) Wacker S.A. … Oswald F. (EMBO J. 2011) 2 3 4 67
  2. RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis. (PMID: 24308154) Wang H. … Liu C. (Oncol. Res. 2013) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. (PMID: 25445601) Wang H. … Chen G. (Biochem. Biophys. Res. Commun. 2014) 3
  5. Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless. (PMID: 25588307) Brockmann B. … Maier D. (Hereditas 2014) 3

Products for RITA1 Gene

Sources for RITA1 Gene

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