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Aliases for RIT2 Gene

Aliases for RIT2 Gene

  • Ras-Like Without CAAX 2 2 3 5
  • Ras-Like Protein Expressed In Neurons 3 4
  • Ras-Like Without CAAX Protein 2 3 4
  • ROC2 3 4
  • RIN 3 4
  • Ric (Drosophila)-Like, Expressed In Neurons 2
  • Ric-Like, Expressed In Neurons 3
  • GTP-Binding Protein Roc2 3
  • RIBA 3

External Ids for RIT2 Gene

Previous HGNC Symbols for RIT2 Gene

  • RIN

Previous GeneCards Identifiers for RIT2 Gene

  • GC18M040529
  • GC18M040109
  • GC18M040211
  • GC18M038575
  • GC18M038577
  • GC18M040323
  • GC18M037181

Summaries for RIT2 Gene

Entrez Gene Summary for RIT2 Gene

  • RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RIT2 Gene

RIT2 (Ras-Like Without CAAX 2) is a Protein Coding gene. Diseases associated with RIT2 include Granulomatous Hepatitis. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Neurotrophic factor-mediated Trk receptor signaling. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RIT2 Gene

  • Binds and exchanges GTP and GDP.

Gene Wiki entry for RIT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIT2 Gene

Genomics for RIT2 Gene

Regulatory Elements for RIT2 Gene

Enhancers for RIT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RIT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIT2 Gene

42,743,218 bp from pter
43,115,692 bp from pter
372,475 bases
Minus strand

Genomic View for RIT2 Gene

Genes around RIT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIT2 Gene

Proteins for RIT2 Gene

  • Protein details for RIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Rit2
    Protein Accession:
    Secondary Accessions:
    • B2R9L1
    • O15295
    • Q8TD69
    • Q8WVF6
    • Q92964

    Protein attributes for RIT2 Gene

    217 amino acids
    Molecular mass:
    24668 Da
    Quaternary structure:
    • Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3.
    • Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

    Alternative splice isoforms for RIT2 Gene


neXtProt entry for RIT2 Gene

Proteomics data for RIT2 Gene at MOPED

Post-translational modifications for RIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIT2 Gene

Antibody Products

  • Abcam antibodies for RIT2

No data available for DME Specific Peptides for RIT2 Gene

Domains & Families for RIT2 Gene

Gene Families for RIT2 Gene

Suggested Antigen Peptide Sequences for RIT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RIT2: view

Function for RIT2 Gene

Molecular function for RIT2 Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.
genes like me logo Genes that share phenotypes with RIT2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RIT2 Gene

Localization for RIT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIT2 Gene

Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane.

Subcellular locations from

Jensen Localization Image for RIT2 Gene COMPARTMENTS Subcellular localization image for RIT2 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RIT2 Gene

Pathways & Interactions for RIT2 Gene

genes like me logo Genes that share pathways with RIT2: view

Gene Ontology (GO) - Biological Process for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0015031 protein transport IEA --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with RIT2: view

No data available for SIGNOR curated interactions for RIT2 Gene

Drugs & Compounds for RIT2 Gene

(4) Drugs for RIT2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIT2: view

Transcripts for RIT2 Gene

Unigene Clusters for RIT2 Gene

Ras-like without CAAX 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for RIT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIT2 Gene

mRNA expression in normal human tissues for RIT2 Gene

mRNA differential expression in normal tissues according to GTEx for RIT2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.0), Brain - Cerebellum (x8.6), Brain - Frontal Cortex (BA9) (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.7), Brain - Hypothalamus (x4.4), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for RIT2 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RIT2 Gene

SOURCE GeneReport for Unigene cluster for RIT2 Gene Hs.464985

mRNA Expression by UniProt/SwissProt for RIT2 Gene

Tissue specificity: Neuron-specific.
genes like me logo Genes that share expression patterns with RIT2: view

Protein tissue co-expression partners for RIT2 Gene

- Elite partner

Primer Products

Orthologs for RIT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RIT2 35
  • 91.4 (n)
  • 96.31 (a)
RIT2 36
  • 96 (a)
(Mus musculus)
Mammalia Rit2 35
  • 87.35 (n)
  • 92.13 (a)
Rit2 16
Rit2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Rit2 35
  • 87.04 (n)
  • 91.67 (a)
(Bos Taurus)
Mammalia -- 36
  • 30 (a)
(Monodelphis domestica)
Mammalia RIT2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia RIT2 36
  • 91 (a)
(Pan troglodytes)
Mammalia RIT2 36
  • 98 (a)
(Gallus gallus)
Aves RIT2 35
  • 79.17 (n)
  • 83.5 (a)
RIT2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia RIT2 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005159 35
  • 61.33 (n)
  • 65.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ric 35
  • 61.11 (n)
  • 66.67 (a)
Ric 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea rap-3 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 36
  • 32 (a)
Species with no ortholog for RIT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RIT2 Gene

Gene Tree for RIT2 (if available)
Gene Tree for RIT2 (if available)

Paralogs for RIT2 Gene Pseudogenes for RIT2 Gene

genes like me logo Genes that share paralogs with RIT2: view

Variants for RIT2 Gene

Sequence variations from dbSNP and Humsavar for RIT2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs4643421 -- 42,914,511(+) taatg(C/T)tgagt intron-variant
rs4643423 -- 42,998,459(+) TTTTA(C/G)CCCAT intron-variant
rs1614902 -- 42,866,580(-) CCAGT(C/T)CCCAA intron-variant
rs1618815 -- 42,921,211(-) GATAG(C/T)AATAA intron-variant
rs1626483 -- 42,775,882(-) CATCT(C/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIT2 Gene

Variant ID Type Subtype PubMed ID
nsv833632 CNV Loss 17160897
nsv2269 CNV Loss 18451855
dgv3410n71 CNV Loss 21882294
nsv470418 CNV Loss 18288195
nsv519875 CNV Gain 19592680
nsv458058 CNV Loss 19166990
nsv522338 CNV Loss 19592680
nsv526691 CNV Loss 19592680
nsv458059 CNV Loss 19166990
nsv458060 CNV Loss 19166990
nsv833633 CNV Gain 17160897
esv990550 CNV Insertion 20482838
nsv131143 CNV Loss 16902084

Variation tolerance for RIT2 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RIT2 Gene

Disorders for RIT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RIT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
granulomatous hepatitis
- elite association - COSMIC cancer census association via MalaCards
Search RIT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RIT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIT2 Gene

Publications for RIT2 Gene

  1. RIC, a calmodulin-binding Ras-like GTPase. (PMID: 8918462) Wes P.D. … Montell C. (EMBO J. 1996) 2 3 4 23 67
  2. Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. (PMID: 16157584) Shi G.X. … Andres D.A. (J. Biol. Chem. 2005) 3 23
  3. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. (PMID: 8824319) Lee C.H.J. … Zack D.J. (J. Neurosci. 1996) 2 3
  4. RIT2 polymorphism is associated with Parkinson's disease in a Han Chinese population. (PMID: 25457028) Nie K. … Wang L.J. (Neurobiol. Aging 2015) 3
  5. The RIT2 and STX1B polymorphisms are associated with Parkinson's disease. (PMID: 25534083) Wang J.Y. … Zhu J.H. (Parkinsonism Relat. Disord. 2015) 3

Products for RIT2 Gene

Sources for RIT2 Gene