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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIT2 Gene

protein-coding   GIFtS: 60
GCID: GC18M040323

Ras-Like Without CAAX 2

(Previous names: Ric (Drosophila)-like, expressed in neurons)
(Previous symbol: RIN)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras-Like Without CAAX 21 2     Ric (Drosophila)-Like, Expressed In Neurons1
RIN1 2 3     RIBA2
Ras-Like Protein Expressed In Neurons2 3     GTP-Binding Protein Rit22
Ras-Like Without CAAX Protein 22 3     GTP-Binding Protein Roc22
ROC22 3     Ric-Like, Expressed In Neurons2

External Ids:    HGNC: 100171   Entrez Gene: 60142   Ensembl: ENSG000001522147   OMIM: 6095925   UniProtKB: Q995783   

Export aliases for RIT2 gene to outside databases

Previous GC identifers: GC18M040529 GC18M040109 GC18M040211 GC18M038575 GC18M038577 GC18M037181


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIT2 Gene:
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 (PubMed
10545207)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RIT2 Gene: 
RIT2 (Ras-like without CAAX 2) is a protein-coding gene. Diseases associated with RIT2 include ehrlichiosis, and cryoglobulinemia, and among its related super-pathways are NGF signalling via TRKA from the plasma membrane and Signalling to RAS. GO annotations related to this gene include calmodulin binding and GTP binding. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578
Function: Binds and exchanges GTP and GDP (By similarity)

Gene Wiki entry for RIT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIT2 gene promoter:
         Pbx1a   HOXA3   AP-1   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   S8   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.3   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q12.3

RIT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIT2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M040323:  view genomic region     (about GC identifiers)

Start:
40,323,192 bp from pter      End:
40,695,657 bp from pter
Size:
372,466 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578 (See protein sequence)
Recommended Name: GTP-binding protein Rit2  
Size: 217 amino acids; 24668 Da
Subunit: Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds
exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3
Subcellular location: Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane
Miscellaneous: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of
most Ras subfamily members (By similarity)
Secondary accessions: B2R9L1 O15295 Q8TD69 Q8WVF6 Q92964
Alternative splicing: 2 isoforms:  Q99578-1   Q99578-2   

Explore the universe of human proteins at neXtProt for RIT2: NX_Q99578

Explore proteomics data for RIT2 at MOPED 

RIT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RIT2 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001259006.1  NP_002921.1  

ENSEMBL proteins: 
 ENSP00000321805   ENSP00000467217   ENSP00000466620   ENSP00000282028  
Reactome Protein details: Q99578
Human Recombinant Protein Products for RIT2: 
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Novus Biologicals RIT2 Protein
Novus Biologicals RIT2 Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for RIT2 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--
GO:0005886plasma membrane TAS8824319
GO:0016020membrane ----

RIT2 for ontologies           About GeneDecksing



RIT2 Antibody Products: 
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LSBio Antibodies in human, mouse, rat for RIT2 

Assay Products for RIT2: 
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Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for RIT2 
Cloud-Clone Corp. CLIAs for RIT2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR027417 P-loop_NTPase
 IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry Q99578

ProtoNet protein and cluster: Q99578

2 Blocks protein domains:
IPB001806 Transforming protein P21 RAS signature
IPB003577 Ras small GTPase


UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578
Similarity: Belongs to the small GTPase superfamily. Ras family


RIT2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RIT2_HUMAN, Q99578
Function: Binds and exchanges GTP and GDP (By similarity)

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity NAS8824319
GO:0005515protein binding ----
GO:0005516calmodulin binding IEA--
GO:0005525GTP binding IEA--
     
RIT2 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for RIT2:
 Decreased Wnt reporter activit  Increased G1 DNA content 

     1 MGI phenotypic allele for Rit2 (no phenotypes)

RIT2 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for RIT2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIT2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIT2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIT2 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIT2
8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate RIT2 (see all 9):
hsa-miR-3673 hsa-miR-206 hsa-miR-548am hsa-miR-1 hsa-miR-222 hsa-miR-221 hsa-miR-548x hsa-miR-590-3p
SwitchGear 3'UTR luciferase reporter plasmidRIT2 3' UTR sequence
Inhib. RNA
Products:
    
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OriGene RNAi products in human, mouse, rat for RIT2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIT2

Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of RIT2

Clone
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OriGene clones in human, mouse for RIT2 (see all 7)
OriGene ORF clones in mouse, rat for RIT2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RIT2 (NM_002930)
Sino Biological Human cDNA Clone for RIT2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIT2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIT2
Sirion Biotech Customized lentivirus for stable overexpression of RIT2 
                     Customized lentivirus expression plasmids for stable overexpression of RIT2 

Cell Line
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GenScript Custom overexpressing Cell Line Services for RIT2
Search LifeMap BioReagents cell lines for RIT2
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIT2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RIT2 About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Signaling by FGFR
NGF signalling via TRKA from the plasma membrane0.71
Signalling by NGF0.71
2Signalling to RAS
Signalling to ERKs0.73
3ARMS-mediated activation
Signalling to p38 via RIT and RIN0.72
4Signaling by GPCR
Signal Transduction0.55
5Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by the MAPK pathway

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for RIT2
    Trk receptor signaling mediated by the MAPK pathway
Neurotrophic factor-mediated Trk receptor signaling


5        Reactome Pathways for RIT2
    Signal Transduction
Signalling by NGF
Signalling to p38 via RIT and RIN
Signalling to ERKs
NGF signalling via TRKA from the plasma membrane



RIT2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/17 Interacting proteins for RIT2 (Q995783 ENSP000003218054) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
CALM2P621583I2D: score=2 
CALM3P621583I2D: score=2 
RLFQ131293, ENSP000003618574I2D: score=3 STRING: ENSP00000361857
HRASP011123, ENSP000003098454I2D: score=1 STRING: ENSP00000309845
About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process ----
GO:0006886intracellular protein transport ----
GO:0006913nucleocytoplasmic transport ----
GO:0007165signal transduction TAS8918462
GO:0007264small GTPase mediated signal transduction TAS--

RIT2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RIT2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RIT2

3 HMDB Compounds for RIT2    About this table
CompoundSynonyms CAS #PubMed Ids
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
Guanosine monophosphate5'-GMP (see all 14)85-32-5--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--

1 Novoseek inferred chemical compound relationship for RIT2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
riboflavin 58 5 9574900 (4), 1541275 (1)

Search CenterWatch for drugs/clinical trials and news about RIT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RIT2 gene (2 alternative transcripts): 
NM_001272077.1  NM_002930.3  

Unigene Cluster for RIT2:

Ras-like without CAAX 2
Hs.464985  [show with all ESTs]
Unigene Representative Sequence: NM_001272077
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000326695(uc002lav.3 uc010dnf.3) ENST00000589109 ENST00000590910
ENST00000594852 ENST00000282028

miRNA
Products:
     
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8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate RIT2 (see all 9):
hsa-miR-3673 hsa-miR-206 hsa-miR-548am hsa-miR-1 hsa-miR-222 hsa-miR-221 hsa-miR-548x hsa-miR-590-3p
SwitchGear 3'UTR luciferase reporter plasmidRIT2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for RIT2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIT2
Clone
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OriGene clones in human, mouse for RIT2 (see all 7)
OriGene ORF clones in mouse, rat for RIT2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RIT2 (NM_002930)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIT2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIT2
Sirion Biotech Customized lentivirus for stable overexpression of RIT2 
                     Customized lentivirus expression plasmids for stable overexpression of RIT2 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RIT2
OriGene qSTAR qPCR primer pairs in human, mouse for RIT2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIT2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIT2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIT2

Additional mRNA sequence: 

AF493922.1 AK313823.1 AY563951.1 BC018060.1 U71204.1 U78164.1 U78166.1 Y07565.1 

5 DOTS entries:

DT.110726  DT.95263311  DT.92428516  DT.92428519  DT.97792300 

24/50 AceView cDNA sequences (see all 50):

BG214444 BG197745 N53351 BG182235 BU736679 BI913514 BG198098 BG193224 
AY563951 BG185364 BG198769 BG207588 BG191657 BG192167 BG194683 BG201449 
BG196707 BG212314 BG200714 BG201452 AF493922 CK023993 BG211783 NM_002930 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RIT2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:                                    
SP2:                          -         


ECgene alternative splicing isoforms for RIT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RIT2 expression in normal human tissues (normalized intensities)      RIT2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATATCTTTGC
RIT2 Expression
About this image


RIT2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Oligodendrocyte Precursor Cells Forebrain White Matter
         ganglion/cranial/glossopharyngeal IX   
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Mature Horizontal Cells Inner Nuclear Layer
 
 Endothelium (Cardiovascular System)
         blood vessel   

See RIT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIT2

SOURCE GeneReport for Unigene cluster: Hs.464985

UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578
Tissue specificity: Neuron-specific

    SABiosciences Custom PCR Arrays for RIT2
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIT2
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIT2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIT2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIT2 gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rit21 , 5 Ras-like without CAAX 21, 5 87.35(n)1
92.13(a)1
  18 (17.69 cM)5
197621  NM_009065.21  NP_033091.11 
 309734895 
chicken
(Gallus gallus)
Aves RIT21 Ras-like without CAAX 2 78.49(n)
82.49(a)
  770660  XM_001233996.2  XP_001233997.2 
lizard
(Anolis carolinensis)
Reptilia RIT26
Uncharacterized protein
78(a)
1 ↔ 1
1(36467320-36682172)
fruit fly
(Drosophila melanogaster)
Insecta Ric1 Ras which interacts with Calmodulin 61.11(n)
66.67(a)
  36776  NM_001169694.1  NP_001163165.1 
worm
(Caenorhabditis elegans)
Secernentea rap-36
Protein RAP-3
36(a)
1 → many
IV(11177286-11178078)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR16
GTP-binding protein of the ras superfamily require...
31(a)
1 → many
VII(794674-795492)


ENSEMBL Gene Tree for RIT2 (if available)
TreeFam Gene Tree for RIT2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RIT2 gene
RAP2C2  DIRAS12  RAP1B2  RALA2  RAP2A2  RIT12  RALB2  RAP1A2  
RAP2B2  NRAS2  DIRAS22  KRAS2  HRAS2  DIRAS32  
18/68 SIMAP similar genes for RIT2 using alignment to 2 protein entries:     RIT2_HUMAN (see all proteins) (see all similar genes):
K-RAS    RIT1    KRAS    c-bas/has    DKFZp547A0616    RAP2B
RAP2A    HRAS    RAP1B    NRAS    RAP2C    RALA
RERG    RALB    RAP1A    MRAS    RRAS2    RAB5C

RIT2 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for RIT2
PGOHUM00000250148


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/6920 SNPs in RIT2 are shown (see all 6920)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 18 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs580716781,2
C--37211769(+) TATGT-/GTATGT
        
AAATA
2 -- int11Minor allele frequency- GTATGT:0.00NA 2
rs169602331,2
C,F,H--40322731(+) GCAAAG/TCATCC 2 -- ds50016Minor allele frequency- T:0.02NA NS 644
rs1858988201,2
--40322809(+) TTTGCC/GACAGC 2 -- ds50010--------
rs774094351,2
C,F--40322876(+) ATACAC/TAGATA 2 -- ds50011Minor allele frequency- T:0.18EA 120
rs1911499481,2
--40322931(+) AATAAA/TTCCTG 2 -- ds50010--------
rs99522321,2
C,F,H--40322969(+) AGAAGC/GACCAT 2 -- ds50019Minor allele frequency- G:0.18NA NS EA WA 680
rs753114051,2
--40323138(+) GCATAC/TTTCCT 2 -- ds50010--------
rs1458530951,2
--40323226(+) GTACTA/GTGTTG 2 -- ut310--------
rs1837555321,2
--40323273(+) TCCATC/GCAACT 2 -- ut310--------
rs757115691,2
C,F--40323383(+) AATATT/GGAAGC 2 -- ut311Minor allele frequency- G:0.01NA 120

HapMap Linkage Disequilibrium report for RIT2 (40323192 - 40573192 bp, first 250kb of RIT2)

Structural Variations
     Database of Genomic Variants (DGV) 10/13 variations for RIT2 (see all 13):    About this table     
Variant IDTypeSubtypePubMed ID
esv990550CNV Insertion20482838
nsv131143CNV Loss16902084
nsv526691CNV Loss19592680
nsv522338CNV Loss19592680
dgv3410n71CNV Loss21882294
nsv470418CNV Loss18288195
nsv2269CNV Loss18451855
nsv458060CNV Loss19166990
nsv833632CNV Loss17160897
nsv458059CNV Loss19166990

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 609592    OMIM disorders: --

10 diseases for RIT2:    About MalaCards
ehrlichiosis    cryoglobulinemia    neuronitis    autoimmune hepatitis
hepatitis    parkinson's disease    hepatitis c    rheumatoid arthritis
schizophrenia    arthritis


RIT2 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): RIT2
Human Genome Epidemiology (HuGE) Navigator: RIT2 (2 documents)

Export disorders for RIT2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RIT2 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with RIT2)
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world of online information

  1. RIC, a calmodulin-binding Ras-like GTPase. (PubMed id 8918462)1, 2, 3, 9 Wes P.D....Montell C. (1996)
  2. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. (PubMed id 8824319)1, 2, 3 Lee C.H.J.... Zack D.J. (1996)
  3. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1, 4 Wang J....Platt A. (2012)
  4. Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)1, 4 Pankratz N....Foroud T. (2012)
  5. Web-based genome-wide association study identifies tw o novel loci and a substantial genetic component for Parkinson's disease. (PubMed id 21738487)1, 4 Do C.B....Eriksson N. (2011)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  7. Strong synaptic transmission impact by copy number va riations in schizophrenia. (PubMed id 20489179)1, 4 Glessner J.T....Hakonarson H. (2010)
  8. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (2009)
  9. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. (PubMed id 16122393)1, 2 Hartwig C....Finckh U. (2005)
  10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6014 HGNC: 10017 AceView: RIT2 Ensembl:ENSG00000152214 euGenes: HUgn6014
ECgene: RIT2 H-InvDB: RIT2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RIT2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RIT2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RIT2 gene:
Search GeneIP for patents involving RIT2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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