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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIT2 Gene

protein-coding   GIFtS: 59
GCID: GC18M040323

Ras-like without CAAX 2

(Previous names: Ric (Drosophila)-like, expressed in neurons )
(Previous symbol: RIN)
 Explore 9 diseases affiliated with
RIT2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RIT2    

Aliases
for RIT2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ras-Like Without CAAX 21 2     ROC22 3
RIN1 2 3     Ric (Drosophila)-Like, Expressed In Neurons1
RIBA1 2     GTP-Binding Protein Rit22
Ras-Like Protein Expressed In Neurons2 3     GTP-Binding Protein Roc22
Ras-Like Without CAAX Protein 22 3     Ric-Like, Expressed In Neurons2

External Ids:    HGNC: 100171   Entrez Gene: 60142   Ensembl: ENSG000001522147   OMIM: 6095925   UniProtKB: Q995783   

Export aliases for RIT2 gene to outside databases

Previous GC identifers: GC18M040529 GC18M040109 GC18M040211 GC18M038575 GC18M038577 GC18M037181


Summaries
for RIT2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RIT2:
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 (PubMed 10545207)).(supplied
by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578
Function: Binds and exchanges GTP and GDP (By similarity)

Gene Wiki entry for RIT2


Genomic Views
for RIT2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIT2 gene promoter:
         Pbx1a   HOXA3   AP-1   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   S8   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RIT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.3   Ensembl cytogenetic band:  18q12.3   HGNC cytogenetic band: 18q12.3

RIT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIT2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M040323:  view genomic region     (about GC identifiers)

Start:
 40,323,192 bp from pter      End:
 40,695,657 bp from pter
Size:
 372,466 bases      Orientation:
 minus strand

Proteins
for RIT2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578 (See protein sequence)
Recommended Name: GTP-binding protein Rit2  
Size: 217 amino acids; 24668 Da
Subunit: Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds
exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3
Subcellular location: Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane
Miscellaneous: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most
Ras subfamily members (By similarity)
Secondary accessions: B2R9L1 O15295 Q8TD69 Q8WVF6 Q92964
Alternative splicing: 2 isoforms:  Q99578-1   Q99578-2   

Explore the universe of human proteins at neXtProt for RIT2: NX_Q99578

RIT2 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (2 alternative transcripts): 
NP_001259006.1  NP_002921.1  

ENSEMBL proteins: 
 ENSP00000321805   ENSP00000467217   ENSP00000466620   ENSP00000282028  
Reactome Protein details: Q99578
Human Recombinant Protein Products: 
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OriGene Purified Protein: RIT2
OriGene Protein Over-expression Lysate: RIT2
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Novus Biologicals RIT2 Protein
Novus Biologicals RIT2 Lysates
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for RIT2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--
GO:0005886plasma membrane TAS8824319


RIT2 for ontologies           About GeneDecksing



RIT2 Antibody Products: 
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Uscn Antibodies for RIT2
ThermoFisher Antibodies for RIT2

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Uscn ELISAs and CLIAs for RIT2

Protein Domains /
Families
for RIT2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
RIT2 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry Q99578

ProtoNet protein and cluster: Q99578

2 Blocks protein families:
IPB001806 Transforming protein P21 RAS signature
IPB003577 Ras small GTPase


UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578
Similarity: Belongs to the small GTPase superfamily. Ras family


Function
for RIT2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578
Function: Binds and exchanges GTP and GDP (By similarity)

miRNA
Products:    		 OriGene 3'-UTR Clone: RIT2
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIT2
8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate RIT2 (see all 9):
hsa-miR-3673 hsa-miR-206 hsa-miR-548am hsa-miR-1 hsa-miR-222 hsa-miR-221 hsa-miR-548x hsa-miR-590-3p
SwitchGear 3'UTR luciferase reporter plasmid: RIT2 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIT2 (see all 7)
OriGene shRNA RFP: RIT2
OriGene siRNA: RIT2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIT2

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for RIT2

Clone
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Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for RIT2
Search LifeMap BioReagents cell lines for RIT2

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIT2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity NAS8824319
GO:0005515protein binding ----
GO:0005516calmodulin binding IEA--
GO:0005525GTP binding IEA--


RIT2 for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for RIT2:
 Decreased Wnt reporter activit  Increased G1 DNA content 

Animal Models:
     1 MGI phenotypic allele for Rit2 (no phenotypes)

RIT2 for phenotypes           About GeneDecksing


Pathways & Interactions
for RIT2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Signaling by FGFR
NGF signalling via TRKA from the plasma membrane0.70
Signalling by NGF0.52
2Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by the MAPK pathway1.00
3Neurotrophic factor-mediated Trk receptor signaling
Neurotrophic factor-mediated Trk receptor signaling1.00
4Signalling to RAS
Signalling to ERKs0.73
5ARMS-mediated activation
Signalling to p38 via RIT and RIN0.72

Pathway sources
See GeneCards unified pathways
Show all pathways


2 BioSystems Pathways for RIT2 
    Trk receptor signaling mediated by the MAPK pathway
Neurotrophic factor-mediated Trk receptor signaling

5        Reactome Pathways for RIT2
    Signal Transduction
Signalling by NGF
Signalling to p38 via RIT and RIN
Signalling to ERKs
NGF signalling via TRKA from the plasma membrane



RIT2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/17 Interacting proteins for RIT2 (Q995783 ENSP000003218054) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
CALM2P621583I2D: score=2 
CALM3P621583I2D: score=2 
RLFQ131293, ENSP000003618574I2D: score=3 STRING: ENSP00000361857
HRASP011123, ENSP000003098454I2D: score=1 STRING: ENSP00000309845
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process ----
GO:0007165signal transduction TAS8918462
GO:0007264small GTPase mediated signal transduction TAS--
GO:0007268synaptic transmission TAS8918462
GO:0048011nerve growth factor receptor signaling pathway TAS--


RIT2 for ontologies           About GeneDecksing



Drugs & Compounds
for RIT2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RIT2 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RIT2

3 HMDB Compounds for RIT2    About this table
CompoundSynonyms CAS #PubMed Ids
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
Guanosine monophosphate5'-GMP (see all 14)85-32-5--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--
1 Novoseek chemical compound relationship for RIT2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
riboflavin 58 5 9574900 (4), 1541275 (1)

Search CenterWatch for drugs/clinical trials and news about RIT2 

Transcripts
for RIT2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for RIT2 gene (2 alternative transcripts): 
NM_001272077.1  NM_002930.3  

Unigene Cluster for RIT2:

Ras-like without CAAX 2
Hs.464985  [show with all ESTs]
Unigene Representative Sequence: U78166
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000326695(uc002lav.3 uc010dnf.3) ENST00000589109 ENST00000590910
ENST00000282028

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIT2
8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate RIT2 (see all 9):
hsa-miR-3673 hsa-miR-206 hsa-miR-548am hsa-miR-1 hsa-miR-222 hsa-miR-221 hsa-miR-548x hsa-miR-590-3p
SwitchGear 3'UTR luciferase reporter plasmid: RIT2 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIT2 (see all 7)
OriGene shRNA RFP: RIT2
OriGene siRNA: RIT2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIT2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIT2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: RIT2 (NM_002930)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIT2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIT2 
Primer
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Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIT2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIT2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIT2

Additional cDNA sequence: 

AF493922.1 AK313823.1 AY563951.1 BC018060.1 U71204.1 U78164.1 U78166.1 Y07565.1 

5 DOTS entries:

DT.110726  DT.95263311  DT.92428516  DT.92428519  DT.97792300 

24/50 AceView cDNA sequences (see all 50):

BG214444 BG197745 BU736679 BG182235 N53351 BG198098 BG194683 BG201449 
BG192167 BG212314 BG196707 BG191657 BG207588 BG193224 BG185364 BG198769 
AY563951 BI913514 BG211783 AF493922 NM_002930 CK023993 Z20231 BG200714 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RIT2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:                                    
SP2:                          -         


ECgene alternative splicing isoforms for RIT2

Expression
for RIT2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RIT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATCTTTGC

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

RIT2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
2 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
EyeInner Nuclear LayerMature Rod Bipolar CellsBipolar, Retina
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells 
NameCategory
ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
Ventral/hypothalamic-like neurons (Generation of midbra...)

See RIT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIT2

SOURCE GeneReport for Unigene cluster: Hs.464985

UniProtKB/Swiss-Prot: RIT2_HUMAN, Q99578
Tissue specificity: Neuron-specific

    SABiosciences Custom PCR Arrays for RIT2
Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIT2

Orthologs
for RIT2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for RIT2 gene from 3/17 species (see all 17)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves RIT21 Ras-like without CAAX 2 78.49(n)
82.49(a)		   770660  XM_001233996.2  XP_001233997.2 
lizard
(Anolis carolinensis)		 Reptilia RIT26
 --
 79(a)
 1 ↔ 1
 1(36467673-36682154)
fruit fly
(Drosophila melanogaster)		 Insecta Ric1 Ras which interacts with Calmodulin 61.11(n)
66.67(a)		   36776  NM_001169694.1  NP_001163165.1 


ENSEMBL Gene Tree for RIT2 (if available)
TreeFam Gene Tree for RIT2 (if available) 

Paralogs
for RIT2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RIT2 gene
REM12  RALA2  RIT12  RRAS2  ERAS2  RALB2  NRAS2  RRAD2  
REM22  KRAS2  GEM2  RRAS22  HRAS2  MRAS2  
18/68 SIMAP similar genes for RIT2 using alignment to 2 protein entries:     RIT2_HUMAN (see all proteins) (see all similar genes):
K-RAS    RIT1    KRAS    c-bas/has    DKFZp547A0616    RAP2B
RAP2A    HRAS    RAP1B    NRAS    RAP2C    RALA
RERG    RALB    RAP1A    MRAS    RRAS2    RAB5C

RIT2 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for RIT2
PGOHUM00000250148


Genomic Variants
for RIT2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/6164 NCBI SNPs in RIT2 are shown (see all 6164)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 18 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs577939731,2
--37465001(+) AAAGAA/CAGAAA 1 -- int10--------
rs169602331,2
C,F,H,--40322731(+) GCAAAG/TCATCC 1 -- int16Minor allele frequency- T:0.02NA NS 644
rs1858988201,2
--40322809(+) TTTGCC/GACAGC 1 -- int10--------
rs774094351,2
F,--40322876(+) ATACAC/TAGATA 1 -- int11Minor allele frequency- T:0.18EA 120
rs1911499481,2
--40322931(+) AATAAA/TTCCTG 1 -- int10--------
rs99522321,2
C,F,H,--40322969(+) AGAAGC/GACCAT 1 -- int19Minor allele frequency- G:0.18NA NS EA WA 680
rs753114051,2
--40323138(+) GCATAC/TTTCCT 1 -- int10--------
rs1458530951,2
--40323226(+) GTACTA/GTGTTG 1 -- ut310--------
rs1837555321,2
--40323273(+) TCCATC/GCAACT 1 -- ut310--------
rs757115691,2
--40323383(+) AATATT/GGAAGC 1 -- ut311Minor allele frequency- G:0.01NA 120

HapMap Linkage Disequilibrium report for RIT2 (40323192 - 40573192 bp, first 250kb of RIT2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RIT2
     1 CNV: 5905
     1 Indel: 49985

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIT2
DNA2.0 Custom Variant and Variant Library Synthesis for RIT2

Disorders / Diseases
for RIT2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
RIT2 for disorders           About GeneDecksing

OMIM gene information: 609592    OMIM disorders: --

9 diseases for RIT2:    About MalaCards
neuronitis    ehrlichiosis    cryoglobulinemia    autoimmune hepatitis
hepatitis c    hepatitis b    parkinson's disease    hepatitis
schizophrenia

Human Genome Epidemiology (HuGE) Navigator: RIT2 (2 documents)

Export disorders for RIT2 gene to outside databases

Publications
for RIT2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RIT2 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with RIT2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. RIC, a calmodulin-binding Ras-like GTPase. (PubMed id 8918462)1, 2, 3, 9 Wes P.D....Montell C. (1996)
  2. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. (PubMed id 8824319)1, 2, 3 Lee C.H.J.... Zack D.J. (1996)
  3. Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. (PubMed id 16122393)1, 2 Hartwig C....Finckh U. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. (PubMed id 16157584)1, 9 Shi G.X....Andres D.A. (2005)
  6. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1 Wang J....Platt A. (2012)
  7. Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)1 Pankratz N....Foroud T. (2012)
  8. Web-based genome-wide association study identifies tw o novel loci and a substantial genetic component for Parkinson's disease. (PubMed id 21738487)1 Do C.B....Eriksson N. (2011)
  9. The plasma membrane-associated GTPase Rin interacts w ith the dopamine transporter and is required for protein kinase C-regulated dop amine transporter trafficking. (PubMed id 21957239)1 Navaroli D.M....Melikian H.E. (2011)
  10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

External Searches for RIT2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing RIT2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6014 HGNC: 10017 AceView: RIT2 Ensembl:ENSG00000152214 euGenes: HUgn6014
ECgene: RIT2 H-InvDB: RIT2

Other Databases showing RIT2 gene

(According to HUGE)
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Specialized Databases showing RIT2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RIT2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RIT2 Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for RIT2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RIT2 gene:
Search GeneIP for patents involving RIT2

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Products
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