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Aliases for RIT2 Gene

Aliases for RIT2 Gene

  • Ras-Like Without CAAX 2 2 3
  • Ras-Like Protein Expressed In Neurons 3 4
  • Ras-Like Without CAAX Protein 2 3 4
  • ROC2 3 4
  • RIN 3 4
  • Ric (Drosophila)-Like, Expressed In Neurons 2
  • Ric-Like, Expressed In Neurons 3
  • GTP-Binding Protein Roc2 3
  • RIBA 3

External Ids for RIT2 Gene

Previous HGNC Symbols for RIT2 Gene

  • RIN

Previous GeneCards Identifiers for RIT2 Gene

  • GC18M040529
  • GC18M040109
  • GC18M040211
  • GC18M038575
  • GC18M038577
  • GC18M040323
  • GC18M037181

Summaries for RIT2 Gene

Entrez Gene Summary for RIT2 Gene

  • RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RIT2 Gene

RIT2 (Ras-Like Without CAAX 2) is a Protein Coding gene. Diseases associated with RIT2 include granulomatous hepatitis. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RIT2 Gene

  • Binds and exchanges GTP and GDP.

Gene Wiki entry for RIT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIT2 Gene

Genomics for RIT2 Gene

Regulatory Elements for RIT2 Gene

Genomic Location for RIT2 Gene

Chromosome:
18
Start:
42,743,218 bp from pter
End:
43,115,692 bp from pter
Size:
372,475 bases
Orientation:
Minus strand

Genomic View for RIT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIT2 Gene

Proteins for RIT2 Gene

  • Protein details for RIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99578-RIT2_HUMAN
    Recommended name:
    GTP-binding protein Rit2
    Protein Accession:
    Q99578
    Secondary Accessions:
    • B2R9L1
    • O15295
    • Q8TD69
    • Q8WVF6
    • Q92964

    Protein attributes for RIT2 Gene

    Size:
    217 amino acids
    Molecular mass:
    24668 Da
    Quaternary structure:
    • Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3.
    Miscellaneous:
    • Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

    Alternative splice isoforms for RIT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIT2 Gene

Proteomics data for RIT2 Gene at MOPED

Post-translational modifications for RIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIT2 Gene

Antibody Products

No data available for DME Specific Peptides for RIT2 Gene

Domains & Families for RIT2 Gene

Gene Families for RIT2 Gene

Suggested Antigen Peptide Sequences for RIT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99578

UniProtKB/Swiss-Prot:

RIT2_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RIT2: view

Function for RIT2 Gene

Molecular function for RIT2 Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.

Gene Ontology (GO) - Molecular Function for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 8824319
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RIT2: view
genes like me logo Genes that share phenotypes with RIT2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RIT2 Gene

Localization for RIT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIT2 Gene

Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIT2 Gene COMPARTMENTS Subcellular localization image for RIT2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS 8824319
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RIT2: view

Pathways & Interactions for RIT2 Gene

genes like me logo Genes that share pathways with RIT2: view

Gene Ontology (GO) - Biological Process for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction TAS 8918462
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007268 synaptic transmission TAS 8918462
genes like me logo Genes that share ontologies with RIT2: view

No data available for SIGNOR curated interactions for RIT2 Gene

Drugs & Compounds for RIT2 Gene

(4) Drugs for RIT2 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riboflavin Approved Nutra 138
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIT2: view

Transcripts for RIT2 Gene

Unigene Clusters for RIT2 Gene

Ras-like without CAAX 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for RIT2 Gene

GeneLoc Exon Structure for
RIT2
ECgene alternative splicing isoforms for
RIT2

Expression for RIT2 Gene

mRNA expression in normal human tissues for RIT2 Gene

mRNA differential expression in normal tissues according to GTEx for RIT2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.0), Brain - Cerebellum (x8.6), Brain - Frontal Cortex (BA9) (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.7), Brain - Hypothalamus (x4.4), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for RIT2 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RIT2 Gene



SOURCE GeneReport for Unigene cluster for RIT2 Gene Hs.464985

mRNA Expression by UniProt/SwissProt for RIT2 Gene

Q99578-RIT2_HUMAN
Tissue specificity: Neuron-specific
genes like me logo Genes that share expression patterns with RIT2: view

Protein tissue co-expression partners for RIT2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for RIT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIT2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RIT2 35
  • 91.4 (n)
  • 96.31 (a)
RIT2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rit2 35
  • 87.35 (n)
  • 92.13 (a)
Rit2 16
Rit2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rit2 35
  • 87.04 (n)
  • 91.67 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 30 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia RIT2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIT2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RIT2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIT2 35
  • 79.17 (n)
  • 83.5 (a)
RIT2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIT2 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005159 35
  • 61.33 (n)
  • 65.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ric 35
  • 61.11 (n)
  • 66.67 (a)
Ric 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rap-3 36
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 36
  • 32 (a)
OneToMany
Species with no ortholog for RIT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RIT2 Gene

ENSEMBL:
Gene Tree for RIT2 (if available)
TreeFam:
Gene Tree for RIT2 (if available)

Paralogs for RIT2 Gene

Pseudogenes.org Pseudogenes for RIT2 Gene

genes like me logo Genes that share paralogs with RIT2: view

Variants for RIT2 Gene

Sequence variations from dbSNP and Humsavar for RIT2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs472591 -- 42,903,657(-) CCTTT(C/T)TGTGG intron-variant
rs473329 -- 42,903,616(-) ATTGA(A/G)GTGAA intron-variant
rs473976 -- 42,838,466(-) CATAA(A/G)CATAC intron-variant
rs474323 -- 42,890,781(-) TCAGT(G/T)TTTAT intron-variant
rs475820 -- 42,745,306(-) CAGCT(G/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIT2 Gene

Variant ID Type Subtype PubMed ID
nsv833632 CNV Loss 17160897
nsv2269 CNV Loss 18451855
dgv3410n71 CNV Loss 21882294
nsv470418 CNV Loss 18288195
nsv519875 CNV Gain 19592680
nsv458058 CNV Loss 19166990
nsv522338 CNV Loss 19592680
nsv526691 CNV Loss 19592680
nsv458059 CNV Loss 19166990
nsv458060 CNV Loss 19166990
nsv833633 CNV Gain 17160897
esv990550 CNV Insertion 20482838
nsv131143 CNV Loss 16902084

Variation tolerance for RIT2 Gene

Residual Variation Intolerance Score: 32.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIT2 Gene

HapMap Linkage Disequilibrium report
RIT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIT2 Gene

Disorders for RIT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RIT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
granulomatous hepatitis
- elite association
Search RIT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RIT2

Genetic Association Database (GAD)
RIT2
Human Genome Epidemiology (HuGE) Navigator
RIT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIT2
genes like me logo Genes that share disorders with RIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIT2 Gene

Publications for RIT2 Gene

  1. RIC, a calmodulin-binding Ras-like GTPase. (PMID: 8918462) Wes P.D. … Montell C. (EMBO J. 1996) 2 23 67
  2. Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. (PMID: 16157584) Shi G.X. … Andres D.A. (J. Biol. Chem. 2005) 23 67
  3. Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development. (PMID: 15712277) Harrison S.M. … Harrison D.A. (Dev. Dyn. 2005) 23 67
  4. Microevolution between paired antral and paired antrum and corpus Helicobacter pylori isolates recovered from individual patients. (PMID: 15184540) Carroll I.M. … Smyth C.J. (J. Med. Microbiol. 2004) 23 67
  5. Identification and separation of PCR products based on their GC content by denaturing high-performance liquid chromatography. (PMID: 15522730) Belda E. … Silva F.J. (J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2004) 23 67

Products for RIT2 Gene

Sources for RIT2 Gene

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