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Aliases for RIT2 Gene

Aliases for RIT2 Gene

  • Ras-Like Without CAAX 2 2 3
  • ROC2 3 4 6
  • RIN 3 4 6
  • Ras-Like Protein Expressed In Neurons 3 4
  • Ras-Like Without CAAX Protein 2 3 4
  • Ric (Drosophila)-Like, Expressed In Neurons 2
  • Ric-Like, Expressed In Neurons 3
  • GTP-Binding Protein Rit2 3
  • GTP-Binding Protein Roc2 3
  • RIBA 3

External Ids for RIT2 Gene

Previous HGNC Symbols for RIT2 Gene

  • RIN

Previous GeneCards Identifiers for RIT2 Gene

  • GC18M040529
  • GC18M040109
  • GC18M040211
  • GC18M038575
  • GC18M038577
  • GC18M040323
  • GC18M037181

Summaries for RIT2 Gene

Entrez Gene Summary for RIT2 Gene

  • RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RIT2 Gene

RIT2 (Ras-Like Without CAAX 2) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is RAP2B.

UniProtKB/Swiss-Prot for RIT2 Gene

  • Binds and exchanges GTP and GDP.

Gene Wiki entry for RIT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIT2 Gene

Genomics for RIT2 Gene

Regulatory Elements for RIT2 Gene

Genomic Location for RIT2 Gene

42,743,218 bp from pter
43,115,692 bp from pter
372,475 bases
Minus strand

Genomic View for RIT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIT2 Gene

Proteins for RIT2 Gene

  • Protein details for RIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Rit2
    Protein Accession:
    Secondary Accessions:
    • B2R9L1
    • O15295
    • Q8TD69
    • Q8WVF6
    • Q92964

    Protein attributes for RIT2 Gene

    217 amino acids
    Molecular mass:
    24668 Da
    Quaternary structure:
    • Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3.
    • Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

    Alternative splice isoforms for RIT2 Gene


neXtProt entry for RIT2 Gene

Proteomics data for RIT2 Gene at MOPED

Post-translational modifications for RIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RIT2 Gene

Domains for RIT2 Gene

Gene Families for RIT2 Gene

Suggested Antigen Peptide Sequences for RIT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RIT2: view

Function for RIT2 Gene

Molecular function for RIT2 Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP.

Gene Ontology (GO) - Molecular Function for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 8824319
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RIT2: view

Phenotypes for RIT2 Gene

GenomeRNAi human phenotypes for RIT2:
genes like me logo Genes that share phenotypes with RIT2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RIT2 Gene

Localization for RIT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIT2 Gene

Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane.

Subcellular locations from

Jensen Localization Image for RIT2 Gene COMPARTMENTS Subcellular localization image for RIT2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS 8824319
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RIT2: view

Pathways for RIT2 Gene

genes like me logo Genes that share pathways with RIT2: view

Gene Ontology (GO) - Biological Process for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006913 nucleocytoplasmic transport --
GO:0007165 signal transduction TAS 8918462
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RIT2: view

Drugs for RIT2 Gene

(3) HMDB Compounds for RIT2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP

(1) Novoseek inferred chemical compound relationships for RIT2 Gene

Compound -log(P) Hits PubMed IDs
riboflavin 58 5
genes like me logo Genes that share compounds with RIT2: view

Transcripts for RIT2 Gene

Unigene Clusters for RIT2 Gene

Ras-like without CAAX 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for RIT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIT2 Gene

mRNA expression in normal human tissues for RIT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIT2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (11.0), Brain - Cerebellum (8.6), Brain - Frontal Cortex (BA9) (4.7), Brain - Nucleus accumbens (basal ganglia) (4.7), Brain - Hypothalamus (4.4), and Brain - Cortex (4.0).

Protein differential expression in normal tissues for RIT2 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RIT2 Gene

SOURCE GeneReport for Unigene cluster for RIT2 Gene Hs.464985

mRNA Expression by UniProt/SwissProt for RIT2 Gene

Tissue specificity: Neuron-specific
genes like me logo Genes that share expressions with RIT2: view

Expression partners for RIT2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for RIT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RIT2 35
  • 91.4 (n)
  • 96.31 (a)
RIT2 36
  • 96 (a)
(Mus musculus)
Mammalia Rit2 35
  • 87.35 (n)
  • 92.13 (a)
Rit2 16
Rit2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Rit2 35
  • 87.04 (n)
  • 91.67 (a)
(Bos Taurus)
Mammalia -- 36
  • 30 (a)
(Monodelphis domestica)
Mammalia RIT2 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia RIT2 36
  • 91 (a)
(Pan troglodytes)
Mammalia RIT2 36
  • 98 (a)
(Gallus gallus)
Aves RIT2 35
  • 79.17 (n)
  • 83.5 (a)
RIT2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia RIT2 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005159 35
  • 61.33 (n)
  • 65.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ric 35
  • 61.11 (n)
  • 66.67 (a)
Ric 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea rap-3 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 36
  • 32 (a)
Species with no ortholog for RIT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RIT2 Gene

Gene Tree for RIT2 (if available)
Gene Tree for RIT2 (if available)

Paralogs for RIT2 Gene Pseudogenes for RIT2 Gene

genes like me logo Genes that share paralogs with RIT2: view

Variants for RIT2 Gene

Sequence variations from dbSNP and Humsavar for RIT2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs472591 -- 42,903,657(-) CCTTT(C/T)TGTGG intron-variant
rs473329 -- 42,903,616(-) ATTGA(A/G)GTGAA intron-variant
rs473976 -- 42,838,466(-) CATAA(A/G)CATAC intron-variant
rs474323 -- 42,890,781(-) TCAGT(G/T)TTTAT intron-variant
rs475820 -- 42,745,306(-) CAGCT(G/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIT2 Gene

Variant ID Type Subtype PubMed ID
nsv833632 CNV Loss 17160897
nsv2269 CNV Loss 18451855
dgv3410n71 CNV Loss 21882294
nsv470418 CNV Loss 18288195
nsv519875 CNV Gain 19592680
nsv458058 CNV Loss 19166990
nsv522338 CNV Loss 19592680
nsv526691 CNV Loss 19592680
nsv458059 CNV Loss 19166990
nsv458060 CNV Loss 19166990
nsv833633 CNV Gain 17160897
esv990550 CNV Insertion 20482838
nsv131143 CNV Loss 16902084

Relevant External Links for RIT2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIT2 Gene

Disorders for RIT2 Gene

Relevant External Links for RIT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RIT2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RIT2 Gene

Publications for RIT2 Gene

  1. RIC, a calmodulin-binding Ras-like GTPase. (PMID: 8918462) Wes P.D. … Montell C. (EMBO J. 1996) 2 3 4 23
  2. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. (PMID: 8824319) Lee C.H.J. … Zack D.J. (J. Neurosci. 1996) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J. … Platt A. (Pharmacogenomics J. 2013) 3 48

Products for RIT2 Gene

Sources for RIT2 Gene

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