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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RIT1 Gene

protein-coding GIFtS: 60
GCID: GC01M155867

Ras-like without CAAX 1

(Previous names: Ric (Drosophila)-like, expressed in many tissues )
(Previous symbol: RIT)

Explore 6 diseases affiliated with
RIT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ras-Like Without CAAX 1¹ ²		MGC125864¹
RIBB¹ ² ³		MGC125865¹
RIT¹ ² ³		Ric (Drosophila)-Like, Expressed In Many Tissues¹
ROC1¹ ² ³		GTP-Binding Protein Rit1²
Ras-Like Protein Expressed In Many Tissues² ³		GTP-Binding Protein Roc1²
Ras-Like Without CAAX Protein 1² ³		Ric-Like, Expressed In Many Tissues²

External Ids:	HGNC: 10023¹	Entrez Gene: 6016²	Ensembl: ENSG00000143622⁷	OMIM: 609591⁵	UniProtKB: Q92963³

Export aliases for RIT1 gene to outside databases

Previous GC identifers: GC01M153733 GC01M151617 GC01M152647 GC01M153086 GC01M152682 GC01M154134 GC01M127228

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIT1:

This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38

MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to

promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. (provided

by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: RIT1_HUMAN, Q92963

Function: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling

pathways and in NGF-dependent neuronal differentiation

Gene Wiki entry for RIT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RIT1 gene promoter:
AREB6 CREB deltaCREB Nkx2-5 CUTL1 RSRFC4 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RIT1 promoter sequence

Search SABiosciences Chromatin IP Primers for RIT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q21.2

RIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIT1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M155867: view genomic region (about GC identifiers)

Start:	155,867,599 bp from pter	End:	155,881,195 bp from pter
Size:	13,597 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RIT1_HUMAN, Q92963 (See protein sequence)

Recommended Name: GTP-binding protein Rit1

Size: 219 amino acids; 25145 Da

Subunit: Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds

exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1

association is dependent upon the GTP-bound state. Interacts with RGL3 (By similarity)

Subcellular location: Cell membrane

Miscellaneous: Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation

Miscellaneous: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most

Ras subfamily members

Secondary accessions: B4DQE8 O00646 O00720 Q5VY90

Alternative splicing: 2 isoforms: Q92963-1 Q92963-2

Explore the universe of human proteins at neXtProt for RIT1: NX_Q92963

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92963

RIT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001243749.1 NP_001243750.1 NP_008843.1

ENSEMBL proteins:

ENSP00000357306 ENSP00000357305 ENSP00000441950

Reactome Protein details: Q92963
Human Recombinant Protein Products for RIT1:

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	Novus Biologicals RIT1 Protein Novus Biologicals RIT1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RIT1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--

RIT1 for ontologies About GeneDecksing

RIT1 Antibody Products:

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	Uscn ELISAs and CLIAs for RIT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RIT1 for domains About GeneDecksing

3 InterPro domains/families:

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

IPR020849 Small_GTPase_Ras

Graphical View of Domain Structure for InterPro Entry Q92963

ProtoNet protein and cluster: Q92963

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB003577 Ras small GTPase

UniProtKB/Swiss-Prot: RIT1_HUMAN, Q92963

Similarity: Belongs to the small GTPase superfamily. Ras family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RIT1_HUMAN, Q92963

Function: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling

pathways and in NGF-dependent neuronal differentiation

Enzyme regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	10545207
GO:0005516	calmodulin binding	TAS	8918462
GO:0005525	GTP binding	IEA	--

RIT1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for RIT1:

Decreased viability with pacli

Increased ID2::GFP protein exp

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rit1):

cellular

RIT1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RIT1

miRNA Products:		OriGene 3'-UTR Clone: RIT1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIT1
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate RIT1 (see all 43):
		hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-29a hsa-miR-624* hsa-miR-1276 hsa-miR-326 hsa-miR-1243 hsa-miR-378

		SwitchGear 3'UTR luciferase reporter plasmid: RIT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIT1 (see all 7) OriGene shRNA RFP: RIT1 OriGene siRNA: RIT1
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIT1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIT1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): RIT1 (NM_001013406)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIT1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling_RalB regulation pathway

Cytoskeleton remodeling RalB regulation pathway

1.00

Cytoskeleton remodeling_RalB regulation pathway

1.00

Signaling by FGFR

NGF signalling via TRKA from the plasma membrane

0.70

Signalling by NGF

0.52

Trk receptor signaling mediated by the MAPK pathway

Trk receptor signaling mediated by the MAPK pathway

1.00

Neurotrophic factor-mediated Trk receptor signaling

Neurotrophic factor-mediated Trk receptor signaling

1.00

Signalling to RAS

Signalling to ERKs

0.73

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RIT1

Cytoskeleton remodeling RalB regulation pathway

1 GeneGo (Thomson Reuters) Pathway for RIT1

Cytoskeleton remodeling RalB regulation pathway

2 BioSystems Pathways for RIT1

	Neurotrophic factor-mediated Trk receptor signaling
	Trk receptor signaling mediated by the MAPK pathway

5 Reactome Pathways for RIT1

	Signal Transduction
	Signalling by NGF
	Signalling to p38 via RIT and RIN
	Signalling to ERKs
	NGF signalling via TRKA from the plasma membrane

RIT1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RIT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/31 Interacting proteins for RIT1 (Q92963^{1, 3} ENSP00000357306⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RLF	Q13129¹^,³, ENSP00000361857⁴	EBI-365845,EBI-958266 I2D: score=4 STRING: ENSP00000361857
SMAD2	Q15796³, ENSP00000262160⁴	I2D: score=4 STRING: ENSP00000262160
SMAD3	P84022³, ENSP00000332973⁴	I2D: score=4 STRING: ENSP00000332973
KLHL12	Q53G59³, ENSP00000356230⁴	I2D: score=2 STRING: ENSP00000356230
SMURF1	Q9HCE7³, ENSP00000354621⁴	I2D: score=2 STRING: ENSP00000354621

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8918462
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0048011	nerve growth factor receptor signaling pathway	TAS	--

RIT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RIT1

3 HMDB Compounds for RIT1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about RIT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RIT1 gene (3 alternative transcripts):

NM_001256820.1 NM_001256821.1 NM_006912.5

Unigene Cluster for RIT1:

Ras-like without CAAX 1

Hs.491234 [show with all ESTs]

Unigene Representative Sequence: NM_006912

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368323(uc001fmh.1 uc010pgr.1) ENST00000368322 ENST00000461050

ENST00000462687 ENST00000539040

miRNA Products:		OriGene 3'-UTR Clone: RIT1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIT1
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate RIT1 (see all 43):
		hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-29a hsa-miR-624* hsa-miR-1276 hsa-miR-326 hsa-miR-1243 hsa-miR-378

		SwitchGear 3'UTR luciferase reporter plasmid: RIT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against RIT1

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		GenScript: all cDNA clones in your preferred vector (see all 5): RIT1 (NM_001013406)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIT1

Additional cDNA sequence:

AF084462.1 AF493923.1 AK298768.1 AK314239.1 BC104186.2 BC104187.2 CR407639.1 U71203.1

U78165.1 Y07566.1

3 DOTS entries:

DT.213852 DT.92069319 DT.439601

24/96 AceView cDNA sequences (see all 96):

CB240948 AA027840 CD364862 BU660907 BF724535 AI382846 BI493568 AI554836

AI086051 AA234344 BQ215658 BU624194 R44194 W92212 AA055067 BM546985

AI088565 BP358660 CA306856 BM973884 BI916790 AW404908 AI870125 BI905803

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RIT1 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c
SP1:											-		-												-
SP2:																									-
SP3:											-		-		-										-
SP4:											-		-												-
SP5:											-		-								-				-

ECgene alternative splicing isoforms for RIT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RIT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCATACCAG

About this image
See RIT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIT1

SOURCE GeneReport for Unigene cluster: Hs.491234

UniProtKB/Swiss-Prot: RIT1_HUMAN, Q92963

Tissue specificity: Expressed in many tissues

SABiosciences Custom PCR Arrays for RIT1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RIT1 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RIT1¹	Ras-like without CAAX 1	79.22(n) 94.44(a)		425068 NM_001031327.1 NP_001026498.1
lizard (Anolis carolinensis)	Reptilia	RIT1⁶	--	80(a)	1 ↔ 1	GL343519.1(456243-463607)
zebrafish (Danio rerio)	Actinopterygii	Dr.19738²	Transcribed sequence with moderate similarity to protein refNP_008843.1 (H.sapiens) Ric-like, expressed in many tissues; Ric (Drosophila)-like, expressed in many tissues [Homo sapiens] less	75.09(n)		57070836
fruit fly (Drosophila melanogaster)	Insecta	Ric⁶	Ras which interacts with Calmodulin	47(a)	1 → many	2R(11994945-11997520)

ENSEMBL Gene Tree for RIT1 (if available)
TreeFam Gene Tree for RIT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RIT1 gene

REM1² RALA² RIT2² RRAS² ERAS² RALB² NRAS² RRAD²

REM2² KRAS² GEM² RRAS2² HRAS² MRAS²

18/80 SIMAP similar genes for RIT1 using alignment to 2 protein entries: RIT1_HUMAN (see all proteins) (see all similar genes):

K-RAS N-ras RIT2 KRAS c-bas/has RAP2A

HRAS DKFZp547A0616 RAP2B RAP2C NRAS RALA

RAP1B RALB RAP1A RERG RRAS2 MRAS

RIT1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RIT1
PGOHUM00000239587

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189053803^1,2		--	155867148(+)	`AGCTAC/TTTGGG`	3	--	ds500¹		0	--	--	--	--
rs192960301^1,2		--	155867190(+)	`GAGGCA/GGAGCT`	3	--	ds500¹		0	--	--	--	--
rs12564928^1,2	C,H	--	155867222(+)	`cactgC/Tactcc`	3	--	ds500¹		1		NA	2
rs66756214^1,2	C	--	155867258(+)	`AAAAAAA/-TCATT`	3	--	ds500¹		1		NA	2
rs115138670^1,2		--	155867315(+)	`ACTTAT/CAACAA`	3	--	ds500¹		1		NA	120
rs184474082^1,2		--	155867367(+)	`TTCCAC/TATGTG`	3	--	ds500¹		0	--	--	--	--
rs150276092^1,2		--	155867506(+)	`GAATAC/TCACAT`	3	--	ds500¹		0	--	--	--	--
rs187405427^1,2		--	155867589(+)	`AAAGGA/G/TAAGCC`	3	--	ds500¹		0	--	--	--	--
rs191788979^1,2		--	155867795(+)	`TTTACC/TGGTCT`	3	--	ut3¹		0	--	--	--	--
rs78912184^1,2	F	--	155867965(+)	`ACTTAT/CGCATA`	3	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for RIT1 (155867599 - 155881195 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RIT1
1 CNV: 6789

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RIT1 for disorders           About GeneDecksing

OMIM gene information: 609591    OMIM disorders: --

6 diseases for RIT1:    About MalaCards

neuronitis pheochromocytoma adhd hepatocellular carcinoma

neuroblastoma carcinoma

1 Novoseek disease relationship for RIT1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	51.3	4	17000774 (1), 15632082 (1), 17976838 (1)

Export disorders for RIT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RIT1 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with RIT1)

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Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. (PubMed id 8824319)^{1, 2, 3, 9} Lee C.H.J.... Zack D.J. (1996)
RIC, a calmodulin-binding Ras-like GTPase. (PubMed id 8918462)^{1, 2, 3} Wes P.D....Montell C. (1996)
Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades. (PubMed id 15632082)^{1, 2, 9} Shi G.-X. and Andres D.A. (2005)
Biochemical characterization of the Ras-related GTPases Rit and Rin. (PubMed id 10545207)^{1, 2} Shao H.... Andres D.A. (1999)
Rit promotes MEK-independent neurite branching in human neuroblastoma cells. (PubMed id 12668729)^{1, 9} Hynds D.L....Snow D.M. (2003)
The Ras branch of small GTPases: Ras family members don't fall far from the tree. (PubMed id 10712923)^{1, 9} Reuther G.W. and Der C.J. (2000)
Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-bi nding protein (CREB) activation cascade. (PubMed id 23038261)¹ Shi G.X....Andres D.A. (2012)
A rit GTPase-p38 mitogen-activated protein kinase sur vival pathway confers resistance to cellular stress. (PubMed id 21444726)¹ Shi G.X....Andres D.A. (2011)
Human immunodeficiency virus type 1 Vpr: functions and molecular interactions. (PubMed id 19458171)¹ Romani B. and Engelbrecht S. (2009)
BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. (PubMed id 18303015)¹ Rondou P....Van Craenenbroeck K. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6016	HGNC: 10023	AceView: RIT1	Ensembl:ENSG00000143622	euGenes: HUgn6016
ECgene: RIT1	H-InvDB: RIT1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RIT1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RIT1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RIT1 gene
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Patent Information for RIT1 gene:
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GeneCards and IP:
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