Aliases for RIT1 Gene
External Ids for RIT1 Gene
Previous HGNC Symbols for RIT1 Gene
Previous GeneCards Identifiers for RIT1 Gene
This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
GeneCards Summary for RIT1 Gene
RIT1 (Ras-Like Without CAAX 1) is a Protein Coding gene. Diseases associated with RIT1 include noonan syndrome 8 and noonan syndrome 1. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is RAP2B.
UniProtKB/Swiss-Prot for RIT1 Gene
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.