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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIT1 Gene

protein-coding   GIFtS: 60
GCID: GC01M155867

Ras-like without CAAX 1

(Previous names: Ric (Drosophila)-like, expressed in many tissues )
(Previous symbol: RIT)
 Explore 6 diseases affiliated with
RIT1 via our new
 Human Malady Compendium 
Biological research products
for RIT1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ras-Like Without CAAX 11 2     MGC1258641
RIBB1 2 3     MGC1258651
RIT1 2 3     Ric (Drosophila)-Like, Expressed In Many Tissues1
ROC11 2 3     GTP-Binding Protein Rit12
Ras-Like Protein Expressed In Many Tissues2 3     GTP-Binding Protein Roc12
Ras-Like Without CAAX Protein 12 3     Ric-Like, Expressed In Many Tissues2

External Ids:    HGNC: 100231   Entrez Gene: 60162   Ensembl: ENSG000001436227   OMIM: 6095915   UniProtKB: Q929633   

Export aliases for RIT1 gene to outside databases

Previous GC identifers: GC01M153733 GC01M151617 GC01M152647 GC01M153086 GC01M152682 GC01M154134 GC01M127228


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIT1:
This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38
MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to
promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: RIT1_HUMAN, Q92963
Function: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling
pathways and in NGF-dependent neuronal differentiation

Gene Wiki entry for RIT1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIT1 gene promoter:
         AREB6   CREB   deltaCREB   Nkx2-5   CUTL1   RSRFC4   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21.2

RIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIT1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155867:  view genomic region     (about GC identifiers)

Start:
155,867,599 bp from pter      End:
155,881,195 bp from pter
Size:
13,597 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RIT1_HUMAN, Q92963 (See protein sequence)
Recommended Name: GTP-binding protein Rit1  
Size: 219 amino acids; 25145 Da
Subunit: Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds
exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1
association is dependent upon the GTP-bound state. Interacts with RGL3 (By similarity)
Subcellular location: Cell membrane
Miscellaneous: Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation
Miscellaneous: Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most
Ras subfamily members
Secondary accessions: B4DQE8 O00646 O00720 Q5VY90
Alternative splicing: 2 isoforms:  Q92963-1   Q92963-2   

Explore the universe of human proteins at neXtProt for RIT1: NX_Q92963

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92963

  • RIT1 Protein expression data from MOPED and PaxDb:    About this image 
    RIT1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243749.1  NP_001243750.1  NP_008843.1  

    ENSEMBL proteins: 
     ENSP00000357306   ENSP00000357305   ENSP00000441950  
    Reactome Protein details: Q92963
    Human Recombinant Protein Products for RIT1: 
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    Novus Biologicals RIT1 Lysate
    Browse Sino Biological Recombinant Proteins
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    Uscn Proteins for RIT1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--

    RIT1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RIT1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RIT1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry Q92963

    ProtoNet protein and cluster: Q92963

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RIT1_HUMAN, Q92963
    Similarity: Belongs to the small GTPase superfamily. Ras family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIT1_HUMAN, Q92963
    Function: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling
    pathways and in NGF-dependent neuronal differentiation
    Enzyme regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI10545207
    GO:0005516calmodulin binding TAS8918462
    GO:0005525GTP binding IEA--
         
    RIT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RIT1:
     Decreased viability with pacli  Increased ID2::GFP protein exp 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rit1):
     cellular 

    RIT1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RIT1 

    miRNA
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    hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-29a hsa-miR-624* hsa-miR-1276 hsa-miR-326 hsa-miR-1243 hsa-miR-378
    SwitchGear 3'UTR luciferase reporter plasmidRIT1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling_RalB regulation pathway
    Cytoskeleton remodeling RalB regulation pathway1.00
    Cytoskeleton remodeling_RalB regulation pathway1.00
    2Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.70
    Signalling by NGF0.52
    3Trk receptor signaling mediated by the MAPK pathway
    Trk receptor signaling mediated by the MAPK pathway1.00
    4Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling1.00
    5Signalling to RAS
    Signalling to ERKs0.73

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RIT1
        Cytoskeleton remodeling RalB regulation pathway


    1 GeneGo (Thomson Reuters) Pathway for RIT1
        Cytoskeleton remodeling RalB regulation pathway

    2 BioSystems Pathways for RIT1 
        Neurotrophic factor-mediated Trk receptor signaling
    Trk receptor signaling mediated by the MAPK pathway

    5        Reactome Pathways for RIT1
        Signal Transduction
    Signalling by NGF
    Signalling to p38 via RIT and RIN
    Signalling to ERKs
    NGF signalling via TRKA from the plasma membrane



    RIT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/31 Interacting proteins for RIT1 (Q929631, 3 ENSP000003573064) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RLFQ131291, 3, ENSP000003618574EBI-365845,EBI-958266 I2D: score=4 STRING: ENSP00000361857
    SMAD2Q157963, ENSP000002621604I2D: score=4 STRING: ENSP00000262160
    SMAD3P840223, ENSP000003329734I2D: score=4 STRING: ENSP00000332973
    KLHL12Q53G593, ENSP000003562304I2D: score=2 STRING: ENSP00000356230
    SMURF1Q9HCE73, ENSP000003546214I2D: score=2 STRING: ENSP00000354621
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8918462
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0048011nerve growth factor receptor signaling pathway TAS--

    RIT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIT1

    3 HMDB Compounds for RIT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about RIT1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIT1 gene (3 alternative transcripts): 
    NM_001256820.1  NM_001256821.1  NM_006912.5  

    Unigene Cluster for RIT1:

    Ras-like without CAAX 1
    Hs.491234  [show with all ESTs]
    Unigene Representative Sequence: NM_006912
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368323(uc001fmh.1 uc010pgr.1) ENST00000368322 ENST00000461050
    ENST00000462687 ENST00000539040

    miRNA
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    hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-29a hsa-miR-624* hsa-miR-1276 hsa-miR-326 hsa-miR-1243 hsa-miR-378
    SwitchGear 3'UTR luciferase reporter plasmidRIT1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF084462.1 AF493923.1 AK298768.1 AK314239.1 BC104186.2 BC104187.2 CR407639.1 U71203.1 
    U78165.1 Y07566.1 

    3 DOTS entries:

    DT.213852  DT.92069319  DT.439601 

    24/96 AceView cDNA sequences (see all 96):

    CB240948 AA027840 CD364862 BU660907 BF724535 AI382846 BI493568 AI554836 
    AI086051 AA234344 BQ215658 BU624194 R44194 W92212 AA055067 BM546985 
    AI088565 BP358660 CA306856 BM973884 BI916790 AW404908 AI870125 BI905803 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RIT1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                                -     -                                   -                                 
    SP2:                                                                          -                                 
    SP3:                                -     -     -                             -                                 
    SP4:                                -     -                                   -                                 
    SP5:                                -     -                       -           -                                 


    ECgene alternative splicing isoforms for RIT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCATACCAG
    RIT1 Expression
    About this image
    See RIT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIT1

    SOURCE GeneReport for Unigene cluster: Hs.491234

    UniProtKB/Swiss-Prot: RIT1_HUMAN, Q92963
    Tissue specificity: Expressed in many tissues

        SABiosciences Custom PCR Arrays for RIT1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RIT1 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RIT11 Ras-like without CAAX 1 79.22(n)
    94.44(a)
      425068  NM_001031327.1  NP_001026498.1 
    lizard
    (Anolis carolinensis)
    Reptilia RIT16
    --
    80(a)
    1 ↔ 1
    GL343519.1(456243-463607)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.197382 Transcribed sequence with moderate similarity to protein more 75.09(n)    57070836 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ric6
    Ras which interacts with Calmodulin
    47(a)
    1 → many
    2R(11994945-11997520)


    ENSEMBL Gene Tree for RIT1 (if available)
    TreeFam Gene Tree for RIT1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIT1 gene
    REM12  RALA2  RIT22  RRAS2  ERAS2  RALB2  NRAS2  RRAD2  
    REM22  KRAS2  GEM2  RRAS22  HRAS2  MRAS2  
    18/80 SIMAP similar genes for RIT1 using alignment to 2 protein entries:     RIT1_HUMAN (see all proteins) (see all similar genes):
    K-RAS    N-ras    RIT2    KRAS    c-bas/has    RAP2A
    HRAS    DKFZp547A0616    RAP2B    RAP2C    NRAS    RALA
    RAP1B    RALB    RAP1A    RERG    RRAS2    MRAS

    RIT1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RIT1
    PGOHUM00000239587


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/247 NCBI SNPs in RIT1 are shown (see all 247    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
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    ----------
    rs1890538031,2
    --155867148(+) AGCTAC/TTTGGG 3 -- ds50010--------
    rs1929603011,2
    --155867190(+) GAGGCA/GGAGCT 3 -- ds50010--------
    rs125649281,2
    C,H--155867222(+) cactgC/Tactcc 3 -- ds50011Minor allele frequency- T:0.00NA 2
    rs667562141,2
    C--155867258(+) AAAAAAA/-TCATT 3 -- ds50011Minor allele frequency- -:0.50NA 2
    rs1151386701,2
    --155867315(+) ACTTAT/CAACAA 3 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1844740821,2
    --155867367(+) TTCCAC/TATGTG 3 -- ds50010--------
    rs1502760921,2
    --155867506(+) GAATAC/TCACAT 3 -- ds50010--------
    rs1874054271,2
    --155867589(+) AAAGGA/G/TAAGCC 3 -- ds50010--------
    rs1917889791,2
    --155867795(+) TTTACC/TGGTCT 3 -- ut310--------
    rs789121841,2
    F--155867965(+) ACTTAT/CGCATA 3 -- ut311Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for RIT1 (155867599 - 155881195 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RIT1
         1 CNV: 6789

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RIT1 for disorders           About GeneDecksing

    OMIM gene information: 609591    OMIM disorders: --

    6 diseases for RIT1:    About MalaCards
    neuronitis    pheochromocytoma    adhd    hepatocellular carcinoma
    neuroblastoma    carcinoma

    1 Novoseek disease relationship for RIT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 51.3 4 17000774 (1), 15632082 (1), 17976838 (1)


    Export disorders for RIT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIT1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with RIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. (PubMed id 8824319)1, 2, 3, 9 Lee C.H.J.... Zack D.J. (1996)
    2. RIC, a calmodulin-binding Ras-like GTPase. (PubMed id 8918462)1, 2, 3 Wes P.D....Montell C. (1996)
    3. Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades. (PubMed id 15632082)1, 2, 9 Shi G.-X. and Andres D.A. (2005)
    4. Biochemical characterization of the Ras-related GTPases Rit and Rin. (PubMed id 10545207)1, 2 Shao H.... Andres D.A. (1999)
    5. Rit promotes MEK-independent neurite branching in human neuroblastoma cells. (PubMed id 12668729)1, 9 Hynds D.L....Snow D.M. (2003)
    6. The Ras branch of small GTPases: Ras family members don't fall far from the tree. (PubMed id 10712923)1, 9 Reuther G.W. and Der C.J. (2000)
    7. Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-bi nding protein (CREB) activation cascade. (PubMed id 23038261)1 Shi G.X....Andres D.A. (2012)
    8. A rit GTPase-p38 mitogen-activated protein kinase sur vival pathway confers resistance to cellular stress. (PubMed id 21444726)1 Shi G.X....Andres D.A. (2011)
    9. Human immunodeficiency virus type 1 Vpr: functions and molecular interactions. (PubMed id 19458171)1 Romani B. and Engelbrecht S. (2009)
    10. BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. (PubMed id 18303015)1 Rondou P....Van Craenenbroeck K. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6016 HGNC: 10023 AceView: RIT1 Ensembl:ENSG00000143622 euGenes: HUgn6016
    ECgene: RIT1 H-InvDB: RIT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RIT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIT1 gene:
    Search GeneIP for patents involving RIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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