Aliases for RIT1 Gene
External Ids for RIT1 Gene
Previous HGNC Symbols for RIT1 Gene
Previous GeneCards Identifiers for RIT1 Gene
This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
GeneCards Summary for RIT1 Gene
RIT1 (Ras Like Without CAAX 1) is a Protein Coding gene. Diseases associated with RIT1 include Noonan Syndrome 8 and Rit1-Related Noonan Syndrome. Among its related pathways are Signaling by GPCR and Neurotrophic factor-mediated Trk receptor signaling. GO annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is RIT2.
UniProtKB/Swiss-Prot for RIT1 Gene
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.