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Aliases for RIPPLY2 Gene

Subcategory (RNA class) for RIPPLY2 Gene


Aliases for RIPPLY2 Gene

  • Ripply Transcriptional Repressor 2 2 3
  • C6orf159 3 4
  • Chromosome 6 Open Reading Frame 159 2
  • Ripply2 Homolog (Zebrafish) 2
  • Protein Ripply2 3
  • Ripply2 Homolog 3
  • DJ237I15.1 3
  • C6orf59 6

External Ids for RIPPLY2 Gene

ORGUL Members for RIPPLY2 Gene

Previous Symbols for RIPPLY2 Gene

  • C6orf159

Summaries for RIPPLY2 Gene

GeneCards Summary for RIPPLY2 Gene

RIPPLY2 (Ripply Transcriptional Repressor 2) is a Protein Coding gene, and belongs to lncRNA RNA class. An important paralog of this gene is RIPPLY1.

UniProtKB/Swiss-Prot for RIPPLY2 Gene

  • Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPPLY2 Gene

Genomics for RIPPLY2 Gene

Genomic Location for RIPPLY2 Gene

83,853,266 bp from pter
83,857,515 bp from pter
4,250 bases
Plus strand

Genomic View for RIPPLY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIPPLY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPPLY2 Gene

Regulatory Elements for RIPPLY2 Gene

Proteins for RIPPLY2 Gene

  • Protein details for RIPPLY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ripply2
    Protein Accession:
    Secondary Accessions:
    • Q5TAB6

    Protein attributes for RIPPLY2 Gene

    128 amino acids
    Molecular mass:
    13906 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RIPPLY2 Gene


neXtProt entry for RIPPLY2 Gene

Proteomics data for RIPPLY2 Gene at MOPED

Post-translational modifications for RIPPLY2 Gene

No Post-translational modifications

Other Protein References for RIPPLY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIPPLY2 Gene

Domains for RIPPLY2 Gene

Protein Domains for RIPPLY2 Gene



  • The ripply homology domain is required for transcriptional repression.:
    • Q5TAB7
  • The WRPW motif is required for binding to tle/groucho proteins.:
    • Q5TAB7
  • Belongs to the ripply family.:
    • Q5TAB7
genes like me logo Genes that share domains with RIPPLY2: view

No data available for Gene Families for RIPPLY2 Gene

Function for RIPPLY2 Gene

Molecular function for RIPPLY2 Gene

UniProtKB/Swiss-Prot Function: Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity).

Gene Ontology (GO) - Molecular Function for RIPPLY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RIPPLY2: view
genes like me logo Genes that share phenotypes with RIPPLY2: view

Animal Models for RIPPLY2 Gene

MGI Knock Outs for RIPPLY2:

miRNA for RIPPLY2 Gene

miRTarBase miRNAs that target RIPPLY2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RIPPLY2 Gene

Localization for RIPPLY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPPLY2 Gene

Subcellular locations from

Jensen Localization Image for RIPPLY2 Gene COMPARTMENTS Subcellular localization image for RIPPLY2 gene
Compartment Confidence
nucleus 4
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for RIPPLY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with RIPPLY2: view

Pathways for RIPPLY2 Gene

SuperPathways for RIPPLY2 Gene

No Data Available

Interacting Proteins for RIPPLY2 Gene

Gene Ontology (GO) - Biological Process for RIPPLY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001756 somitogenesis ISS --
GO:0007219 Notch signaling pathway IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0009798 axis specification --
genes like me logo Genes that share ontologies with RIPPLY2: view

No data available for Pathways by source for RIPPLY2 Gene

Transcripts for RIPPLY2 Gene

mRNA/cDNA for RIPPLY2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RIPPLY2 Gene

Ripply2 homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIPPLY2 Gene

No ASD Table

Relevant External Links for RIPPLY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIPPLY2 Gene

mRNA expression in normal human tissues for RIPPLY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIPPLY2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.4), Brain - Nucleus accumbens (basal ganglia) (4.4), Brain - Cerebellum (4.3), Brain - Putamen (basal ganglia) (4.1), and Brain - Frontal Cortex (BA9) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RIPPLY2 Gene

SOURCE GeneReport for Unigene cluster for RIPPLY2 Gene Hs.149454

genes like me logo Genes that share expressions with RIPPLY2: view

Orthologs for RIPPLY2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPPLY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RIPPLY2 36
  • 98.96 (n)
  • 97.66 (a)
  • 98 (a)
(Bos Taurus)
Mammalia LOC781965 36
  • 82.87 (n)
  • 76.15 (a)
  • 54 (a)
(Canis familiaris)
Mammalia RIPPLY2 37
  • 66 (a)
(Mus musculus)
Mammalia Ripply2 36
  • 73.11 (n)
  • 69.75 (a)
Ripply2 16
Ripply2 37
  • 63 (a)
(Rattus norvegicus)
Mammalia Ripply2 36
  • 71.15 (n)
  • 66.39 (a)
(Gallus gallus)
Aves RIPPLY2 37
  • 44 (a)
(Anolis carolinensis)
Reptilia RIPPLY2 37
  • 36 (a)
(Danio rerio)
Actinopterygii ripply2 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
Species with no ortholog for RIPPLY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIPPLY2 Gene

Gene Tree for RIPPLY2 (if available)
Gene Tree for RIPPLY2 (if available)

Paralogs for RIPPLY2 Gene

Paralogs for RIPPLY2 Gene

Selected SIMAP similar genes for RIPPLY2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RIPPLY2: view

Variants for RIPPLY2 Gene

Sequence variations from dbSNP and Humsavar for RIPPLY2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1325472 -- 83,856,634(-) TTGAT(A/T)CTATG intron-variant
rs2298287 -- 83,854,424(-) GCTCT(C/T)TTACC intron-variant
rs2298288 -- 83,854,356(-) ATCAA(C/T)AGTCC intron-variant
rs2298289 -- 83,854,073(-) GAATC(C/T)AGTTA intron-variant
rs2298290 -- 83,853,691(-) ATCTG(C/T)GGGAT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for RIPPLY2 Gene

Variant ID Type Subtype PubMed ID
nsv886330 CNV Gain 21882294
nsv830718 CNV Gain+Loss 17160897

Relevant External Links for RIPPLY2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for RIPPLY2 Gene

Relevant External Links for RIPPLY2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RIPPLY2: view

No data available for UniProtKB/Swiss-Prot for RIPPLY2 Gene

Publications for RIPPLY2 Gene

  1. Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. (PMID: 16326386) Kawamura A. … Takada S. (Dev. Cell 2005) 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for RIPPLY2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RIPPLY2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RIPPLY2
    • Block miRNA regulation of RIPPLY2 using miScript Target Protectors
    • antibodies-online proteins for RIPPLY2
    • antibodies-online antibodies for RIPPLY2
    • antibodies-online kits for RIPPLY2

    Sources for RIPPLY2 Gene

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