RIPPLY2 Gene
protein-coding GIFtS: 37
GCID: GC06P084562
|
|
ripply2 homolog (zebrafish)(Previous name: chromosome 6 open reading frame 159 )
(Previous symbol: C6orf159)
| |
Aliases
for RIPPLY2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Ripply2 Homolog (Zebrafish)1 2 | | C6orf1591 2 3 | | DJ237I15.11 | | Chromosome 6 Open Reading Frame 1591 | | Protein Ripply22 | | C6orf595 |
| External Ids: | HGNC: 213901 | Entrez Gene: 1347012 | Ensembl: ENSG000002038777 | OMIM: 6098915 | UniProtKB: Q5TAB73 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n342077 | |
Export aliases for RIPPLY2 gene to outside databasesPrevious GC identifers: GC06M161503 GC06P084620 GC06P084621 GC06P081792
Summaries
for RIPPLY2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RIPP2_HUMAN, Q5TAB7Function: Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity insomites (By similarity)
|
Genomic Views
for RIPPLY2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RIPPLY2 gene promoter:
SREBP-1c POU6F1 (c2) Cdc5 SREBP-1b S8 Ik-2 SREBP-1a ARP-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RIPPLY2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPPLY2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q14.2 Ensembl cytogenetic band: 6q14.2 HGNC cytogenetic band: 6q14.2RIPPLY2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P084562: view genomic region
(about GC identifiers)
Start:
|
84,562,985 bp from pter |
End:
|
84,567,234 bp from pter |
Size:
|
4,250 bases |
Orientation:
|
plus strand |
|
Proteins
for RIPPLY2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RIPP2_HUMAN, Q5TAB7 (See
protein sequence)Recommended Name: Protein ripply2 Size: 128 amino acids; 13906 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5TAB6Alternative splicing: 2 isoforms: Q5TAB7-1 Q5TAB7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RIPPLY2: NX_Q5TAB7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TAB7
RIPPLY2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001009994.1
ENSEMBL proteins: ENSP00000358703 ENSP00000358701
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
ISS | -- |
RIPPLY2 for ontologies About GeneDecksing
RIPPLY2 Antibody Products:
Assay Products for RIPPLY2: |
Protein
Domains /
Families
for RIPPLY2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5TAB7 UniProtKB/Swiss-Prot: RIPP2_HUMAN, Q5TAB7Domain: The ripply homology domain is required for transcriptional repression (By similarity)Domain: The WRPW motif is required for binding to tle/groucho proteins (By similarity)Similarity: Belongs to the ripply family |
Function
for RIPPLY2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RIPP2_HUMAN, Q5TAB7Function: Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity insomites (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPPLY2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPPLY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RIPPLY2 (NM_001009994) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIPPLY2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPPLY2 |
Animal Models:
Mouse knock-out Ripply2tm1.1Ysa for RIPPLY2
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ripply2):
RIPPLY2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RIPPLY2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIPPLY2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RIPPLY2 (ENSP000003587034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
RIPPLY2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RIPPLY2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RIPPLY2
Search CenterWatch for drugs/clinical trials and news about RIPPLY2 / RIPP2
|
Transcripts
for RIPPLY2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RIPPLY2 gene: NM_001009994.1 Unigene Cluster for RIPPLY2: Ripply2 homolog (zebrafish) Hs.149454 [show with all ESTs]Unigene Representative Sequence: AK1241052 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369689(uc003pke.3) ENST00000369687
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPPLY2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPPLY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RIPPLY2 (NM_001009994) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIPPLY2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPPLY2 |
Additional cDNA sequence: AK124105.1 BC130460.1 BC132968.1 3 DOTS entries: DT.75100188 DT.92414210 DT.99973604 14 AceView cDNA sequences: AI992060 BM313825 CK905194 BE672047 AW163257 BM314104 AI359993 BQ941932 AI621284 BM782014 AK124105 AI279191 AW511485 CK905195
GeneLoc Exon Structure
|
Expression
for RIPPLY2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RIPPLY2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RIPPLY2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIPPLY2
SOURCE GeneReport for Unigene cluster: Hs.149454
SABiosciences Custom PCR Arrays for RIPPLY2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIPPLY2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RIPPLY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPPLY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPPLY2 |
Orthologs
for RIPPLY2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RIPPLY2 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RIPPLY26 |
Uncharacterized protein |
53(a) |
1 ↔ 1 |
3(80316666-80318647) |
lizard
(Anolis carolinensis) |
Reptilia |
RIPPLY26 |
-- |
65(a) |
1 ↔ 1 |
1(197215012-197319746) |
zebrafish
(Danio rerio) |
Actinopterygii |
ripply26ripply16 |
ripply1 |
39(a)36(a) |
1 ↔ many1 ↔ many |
4(681199-683374) 21(36930713-36937075) |
ENSEMBL Gene Tree for RIPPLY2 (if available)
TreeFam Gene Tree for RIPPLY2 (if available) |
Paralogs
for RIPPLY2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RIPPLY2 gene
- DSCR62 RIPPLY12
1 SIMAP similar gene for RIPPLY2 using alignment to 1 protein entry: RIPP2_HUMAN:RIPPLY1
RIPPLY2 for paralogs About GeneDecksing
|
Genomic Variants
for RIPPLY2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RIPPLY2 (84562985 - 84567234 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RIPPLY2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIPPLY2 |
|
Disorders
/ Diseases
for RIPPLY2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RIPPLY2 for disorders About MalaCards
RIPPLY2 for disorders About GeneDecksing
OMIM gene information: 609891
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: RIPPLY2 (3 documents)
Export disorders for RIPPLY2 gene to outside databases
|
Publications
for RIPPLY2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RIPPLY2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RIPPLY2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. (PubMed id 16326386)1, 2 Kawamura A....Takada S. (2005)
- Novel cleft susceptibility genes in chromosome 6q. (PubMed id 20511563)1 Letra A....Vieira A.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Ripply2 is essential for precise somite formation during mouse early development. (PubMed id 17531978)1 Chan T....Asashima M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RIPPLY2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RIPPLY2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RIPPLY2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RIPPLY2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RIPPLY2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RIPPLY2 gene:
Search GeneIP for patents involving RIPPLY2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RIPPLY2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RIPPLY2 | | OriGene shRNA RFP for RIPPLY2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIPPLY2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIPPLY2 | | | OriGene Protein Over-expression Lysate for RIPPLY2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RIPPLY2 | | OriGene 3'-UTR Clone for RIPPLY2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPPLY2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPPLY2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RIPPLY2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RIPPLY2 | | OriGene Custom Protein Services for RIPPLY2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RIPPLY2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIPPLY2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPPLY2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIPPLY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPPLY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPPLY2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RIPPLY2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RIPPLY2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RIPPLY2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPPLY2 |
|
|
|
|
GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356980-web2.xennexinc.com
index build: 100 solr: 1.4
|
