Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIPPLY2 Gene

protein-coding   GIFtS: 40
GCID: GC06P084562

Ripply Transcriptional Repressor 2

(Previous names: chromosome 6 open reading frame 159, ripply2 homolog (zebrafish))
(Previous symbol: C6orf159)
  Search for RIPPLY2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ripply Transcriptional Repressor 21 2     dJ237I15.12
C6orf1591 2 3     Protein Ripply22
Chromosome 6 Open Reading Frame 1591     Ripply2 Homolog2
Ripply2 Homolog (Zebrafish)1     C6orf595

External Ids:    HGNC: 213901   Entrez Gene: 1347012   Ensembl: ENSG000002038777   OMIM: 6098915   UniProtKB: Q5TAB73   
ORGUL members:         
NONCODE14:n342077      

Export aliases for RIPPLY2 gene to outside databases

Previous GC identifers: GC06M161503 GC06P084620 GC06P084621 GC06P081792


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RIPPLY2 Gene: 
RIPPLY2 (ripply transcriptional repressor 2) is a protein-coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is RIPPLY1.

UniProtKB/Swiss-Prot: RIPP2_HUMAN, Q5TAB7
Function: Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal
polarity in somites (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIPPLY2 gene promoter:
         SREBP-1c   POU6F1 (c2)   Cdc5   SREBP-1b   S8   Ik-2   SREBP-1a   ARP-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RIPPLY2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPPLY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.2   Ensembl cytogenetic band:  6q14.2   HGNC cytogenetic band: 6q14.2

RIPPLY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIPPLY2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P084562:  view genomic region     (about GC identifiers)

Start:
84,562,985 bp from pter      End:
84,567,234 bp from pter
Size:
4,250 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIPP2_HUMAN, Q5TAB7 (See protein sequence)
Recommended Name: Protein ripply2  
Size: 128 amino acids; 13906 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5TAB6
Alternative splicing: 2 isoforms:  Q5TAB7-1   Q5TAB7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIPPLY2: NX_Q5TAB7

Explore proteomics data for RIPPLY2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TAB7

  • RIPPLY2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIPPLY2 Protein Expression
    REFSEQ proteins: NP_001009994.1  
    ENSEMBL proteins: 
     ENSP00000358703   ENSP00000358701  

    Human Recombinant Protein Products for RIPPLY2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RIPPLY2
    OriGene Protein Over-expression Lysate for RIPPLY2
    OriGene MassSpec for RIPPLY2 
    OriGene Custom Protein Services for RIPPLY2
    GenScript Custom Purified and Recombinant Proteins Services for RIPPLY2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIPPLY2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    RIPPLY2 for ontologies           About GeneDecksing



    RIPPLY2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RIPPLY2
    OriGene Custom Antibody Services for RIPPLY2
    GenScript Custom Superior Antibodies Services for RIPPLY2
    Abcam antibodies for RIPPLY2
    Cloud-Clone Corp. Antibodies for RIPPLY2 
    Search ThermoFisher Antibodies for RIPPLY2
    LSBio Antibodies in human, mouse, rat for RIPPLY2 

    Assay Products for RIPPLY2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RIPPLY2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RIPPLY2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RIPPLY2 
    Cloud-Clone Corp. CLIAs for RIPPLY2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5TAB7

    UniProtKB/Swiss-Prot: RIPP2_HUMAN, Q5TAB7
    Domain: The ripply homology domain is required for transcriptional repression (By similarity)
    Domain: The WRPW motif is required for binding to tle/groucho proteins (By similarity)
    Similarity: Belongs to the ripply family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIPP2_HUMAN, Q5TAB7
    Function: Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal
    polarity in somites (By similarity)

    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ripply2):

     embryogenesis  growth/size  limbs/digits/tail  mortality/aging  muscle 
     respiratory system  skeleton 

    RIPPLY2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ripply2tm1.1Ysa for RIPPLY2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIPPLY2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIPPLY2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIPPLY2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIPPLY2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIPPLY2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RIPPLY2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RIPPLY2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIPPLY2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RIPPLY2
    Sirion Biotech Customized adenovirus for overexpression of RIPPLY2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RIPPLY2 (see all 7)
    OriGene ORF clones in mouse, rat for RIPPLY2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIPPLY2 (NM_001009994)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIPPLY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPPLY2
    Sirion Biotech Customized lentivirus for stable overexpression of RIPPLY2 
                         Customized lentivirus expression plasmids for stable overexpression of RIPPLY2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RIPPLY2
    Search LifeMap BioReagents cell lines for RIPPLY2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPPLY2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIPPLY2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RIPPLY2 (ENSP000003587034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM71ENSP000003732724STRING: ENSP00000373272
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001756somitogenesis ISS--
    GO:0007368determination of left/right symmetry IEA--
    GO:0009798axis specification ----
    GO:0032525somite rostral/caudal axis specification ISS--

    RIPPLY2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIPPLY2 (RIPP2)

    Search CenterWatch for drugs/clinical trials and news about RIPPLY2 / RIPP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIPPLY2 gene: 
    NM_001009994.2  

    Unigene Cluster for RIPPLY2:

    Ripply2 homolog (zebrafish)
    Hs.149454  [show with all ESTs]
    Unigene Representative Sequence: AK124105
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369689(uc003pke.3) ENST00000369687
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIPPLY2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RIPPLY2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RIPPLY2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIPPLY2
    Clone
    Products:
         
    OriGene clones in human, mouse for RIPPLY2 (see all 7)
    OriGene ORF clones in mouse, rat for RIPPLY2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIPPLY2 (NM_001009994)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIPPLY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPPLY2
    Sirion Biotech Customized lentivirus for stable overexpression of RIPPLY2 
                         Customized lentivirus expression plasmids for stable overexpression of RIPPLY2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RIPPLY2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RIPPLY2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPPLY2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPPLY2

    Additional mRNA sequence: 

    AK124105.1 BC130460.1 BC132968.1 

    3 DOTS entries:

    DT.75100188  DT.92414210  DT.99973604 

    14 AceView cDNA sequences:

    AI992060 BE672047 CK905194 BM313825 AK124105 AI359993 BM314104 AW511485 
    AI279191 AW163257 BQ941932 BM782014 AI621284 CK905195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIPPLY2 expression in normal human tissues (normalized intensities)      RIPPLY2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RIPPLY2 Expression
    About this image


    RIPPLY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle

    See RIPPLY2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIPPLY2

    SOURCE GeneReport for Unigene cluster: Hs.149454
        SABiosciences Custom PCR Arrays for RIPPLY2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RIPPLY2
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RIPPLY2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPPLY2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPPLY2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPPLY2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RIPPLY2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ripply21 , 5 ripply2 homolog (zebrafish)1, 5 72.55(n)1
    69.75(a)1
      9 (46.69 cM)5
    3820891  NM_001037907.11  NP_001032996.11 
     870155375 
    chicken
    (Gallus gallus)
    Aves RIPPLY26
    Uncharacterized protein
    43(a)
    1 ↔ 1
    3(76997777-76999819)
    lizard
    (Anolis carolinensis)
    Reptilia RIPPLY26
    ripply2 homolog (zebrafish)
    36(a)
    1 ↔ 1
    1(197315564-197326799)
    zebrafish
    (Danio rerio)
    Actinopterygii ripply26
    ripply2
    39(a)
    1 ↔ 1
    4(681199-683374)


    ENSEMBL Gene Tree for RIPPLY2 (if available)
    TreeFam Gene Tree for RIPPLY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIPPLY2 gene
    RIPPLY12  
    1 SIMAP similar gene for RIPPLY2 using alignment to 1 protein entry:     RIPP2_HUMAN:
    RIPPLY1

    RIPPLY2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/121 SNPs in RIPPLY2 are shown (see all 121)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848314051,2
    --84560994(+) GAATAA/CCTTAC 1 -- us2k10--------
    rs2002723511,2
    --84561053(+) AAAGA-/TTTTTTT 1 -- us2k10--------
    rs77486771,2
    C--84561060(+) TTTTTT/ATAttt 1 -- us2k13Minor allele frequency- A:0.24WA EA 240
    rs64543411,2
    C,A--84561061(+) TTTTTT/AAtttt 1 -- us2k13Minor allele frequency- A:0.36WA EA 240
    rs1395791841,2
    C--84561142(+) ATGGTA/GGTTTG 1 -- us2k10--------
    rs1897751891,2
    --84561143(+) TGGTGC/GTTTGC 1 -- us2k10--------
    rs64543421,2
    C,F,A--84561163(+) caaccC/Tatcac 1 -- us2k14Minor allele frequency- T:0.33NA WA CSA 6
    rs1477992771,2
    C--84561191(+) CATGCA/GTTAGC 1 -- us2k10--------
    rs1809710901,2
    --84561239(+) ACTGAC/TATGCC 1 -- us2k10--------
    rs1411221691,2
    --84561354(+) GCTGAG/TGATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RIPPLY2 (84562985 - 84567234 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RIPPLY2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv886330CNV Gain21882294
    nsv830718CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RIPPLY2
    DNA2.0 Custom Variant and Variant Library Synthesis for RIPPLY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RIPPLY2 for disorders           About MalaCards
    OMIM gene information: 609891    OMIM disorders: --


    RIPPLY2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RIPPLY2
    Human Genome Epidemiology (HuGE) Navigator: RIPPLY2 (3 documents)

    Export disorders for RIPPLY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIPPLY2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RIPPLY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. (PubMed id 16326386)1, 2 Kawamura A....Takada S. (2005)
    3. Novel cleft susceptibility genes in chromosome 6q. (PubMed id 20511563)1 Letra A....Vieira A.R. (2010)
    4. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    5. Ripply2 is essential for precise somite formation during mouse early development. (PubMed id 17531978)1 Chan T....Asashima M. (2007)
    6. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 134701 HGNC: 21390 AceView: C6orf159 Ensembl:ENSG00000203877 euGenes: HUgn134701
    ECgene: RIPPLY2 H-InvDB: RIPPLY2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIPPLY2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIPPLY2 gene:
    Search GeneIP for patents involving RIPPLY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RIPPLY2   OriGene RNAi products in human, mouse, rat for RIPPLY2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RIPPLY2  
     OriGene MassSpec something-or-other for RIPPLY2   OriGene clones in human, mouse for RIPPLY2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RIPPLY2   OriGene Purified Protein for RIPPLY2  
     OriGene ORF clones in mouse, rat for RIPPLY2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RIPPLY2   OriGene Custom Protein Services for RIPPLY2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RIPPLY2
     QIAGEN SeqTarget long-range PCR primers for resequencing RIPPLY2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPPLY2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIPPLY2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPPLY2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPPLY2
     GenScript Custom Purified and Recombinant Proteins Services for RIPPLY2 GenScript cDNA clones with any tag delivered in your preferred vector for RIPPLY2
     GenScript Custom Assay Services for RIPPLY2 GenScript Custom Superior Antibodies Services for RIPPLY2
     GenScript Custom overexpressing Cell Line Services for RIPPLY2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RIPPLY2 promoter
     Search Chromatin IP Primers for RIPPLY2
     RT2 qPCR Primer Assay in human, mouse / rat RIPPLY2
     Search GNC Networks for RIPPLY2
     SABiosciences Custom PCR Arrays for RIPPLY2
     Search Tocris compounds for RIPPLY2 (RIPP2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Antibodies for RIPPLY2
     See all of Abcam's Antibodies, Kits and Proteins for RIPPLY2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RIPPLY2
     Antibodies for RIPPLY2
     ELISAs for RIPPLY2
     CLIAs for RIPPLY2
     Search LifeMap BioReagents cell lines for RIPPLY2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPPLY2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RIPPLY2
     Browse SwitchGear Promoter luciferase reporter plasmids for RIPPLY2
     Search ThermoFisher Antibodies for RIPPLY2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPPLY2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RIPPLY2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIPPLY2
    Customized:
     lentivirus for stable overexpression of RIPPLY2
     lentivirus expression plasmids for stable overexpression of RIPPLY2
     adenovirus for overexpression of RIPPLY2
     LSBio Antibodies in human, mouse, rat for RIPPLY2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RIPPLY2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4