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Aliases for RIPPLY1 Gene

Aliases for RIPPLY1 Gene

  • Ripply Transcriptional Repressor 1 2 3 5
  • Ripply1 Homolog (Zebrafish) 2

External Ids for RIPPLY1 Gene

Previous GeneCards Identifiers for RIPPLY1 Gene

  • GC0XM106029
  • GC0XM106143
  • GC0XM095771

Summaries for RIPPLY1 Gene

Entrez Gene Summary for RIPPLY1 Gene

  • This gene encodes a protein similar to a zebrafish protein which acts as a transcriptional repressor in and is required for somite segmentation in zebrafish embryos (PMID: 16326386). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for RIPPLY1 Gene

RIPPLY1 (Ripply Transcriptional Repressor 1) is a Protein Coding gene. An important paralog of this gene is RIPPLY2.

UniProtKB/Swiss-Prot for RIPPLY1 Gene

  • Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity).

Additional gene information for RIPPLY1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPPLY1 Gene

Genomics for RIPPLY1 Gene

Regulatory Elements for RIPPLY1 Gene

Enhancers for RIPPLY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH106927 1.3 Ensembl ENCODE dbSUPER 13.5 -27.5 -27532 7 ELF3 SOX13 TFAP4 MAX ZNF384 RAD21 YY1 ZFHX2 FOS NR2F6 RIPPLY1 MYCLP1 TBC1D8B PIR48891 GC0XM106980
GH0XH106901 0.9 ENCODE dbSUPER 0.7 +0.9 868 2 MAX EBF1 ZNF644 RAD21 YY1 JUND ATF3 GLIS1 HNF4G HNF4A RIPPLY1 CLDN2
GH0XH106905 0.8 ENCODE dbSUPER 0.7 -2.9 -2921 2 SCRT1 MAX REST HNF4A ZNF398 RFX5 SPI1 RIPPLY1 PIR48891
GH0XH106912 0.5 dbSUPER 0.4 -10.2 -10152 1 JUND ATF3 MAX HNF4A RIPPLY1 PIR48891
GH0XH106917 0.5 ENCODE 0.4 -15.0 -15023 0 JUND POLR2A EP300 TCF7L2 PIR48891 RIPPLY1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIPPLY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIPPLY1 Gene

Chromosome:
X
Start:
106,900,063 bp from pter
End:
106,903,335 bp from pter
Size:
3,273 bases
Orientation:
Minus strand

Genomic View for RIPPLY1 Gene

Genes around RIPPLY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPPLY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPPLY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPPLY1 Gene

Proteins for RIPPLY1 Gene

  • Protein details for RIPPLY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0D2K3-RIPP1_HUMAN
    Recommended name:
    Protein ripply1
    Protein Accession:
    Q0D2K3
    Secondary Accessions:
    • A0JP63
    • Q0VGB3
    • Q5JRB8
    • Q5JRB9

    Protein attributes for RIPPLY1 Gene

    Size:
    151 amino acids
    Molecular mass:
    16379 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10437.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI40159.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI40160.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RIPPLY1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPPLY1 Gene

Post-translational modifications for RIPPLY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIPPLY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIPPLY1 Gene

Domains & Families for RIPPLY1 Gene

Gene Families for RIPPLY1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RIPPLY1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RIPPLY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0D2K3

UniProtKB/Swiss-Prot:

RIPP1_HUMAN :
  • The ripply homology domain is required for transcriptional repression.
  • Belongs to the ripply family.
Domain:
  • The ripply homology domain is required for transcriptional repression.
  • The WRPW motif is required for binding to TLE/GROUCHO proteins.
Family:
  • Belongs to the ripply family.
genes like me logo Genes that share domains with RIPPLY1: view

Function for RIPPLY1 Gene

Molecular function for RIPPLY1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity).

Gene Ontology (GO) - Molecular Function for RIPPLY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RIPPLY1: view

Phenotypes for RIPPLY1 Gene

GenomeRNAi human phenotypes for RIPPLY1:
genes like me logo Genes that share phenotypes with RIPPLY1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RIPPLY1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RIPPLY1 Gene

Localization for RIPPLY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPPLY1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPPLY1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RIPPLY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
genes like me logo Genes that share ontologies with RIPPLY1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RIPPLY1 Gene

Pathways & Interactions for RIPPLY1 Gene

SuperPathways for RIPPLY1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIPPLY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0001757 somite specification ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007219 Notch signaling pathway IEA --
genes like me logo Genes that share ontologies with RIPPLY1: view

No data available for Pathways by source and SIGNOR curated interactions for RIPPLY1 Gene

Drugs & Compounds for RIPPLY1 Gene

No Compound Related Data Available

Transcripts for RIPPLY1 Gene

mRNA/cDNA for RIPPLY1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RIPPLY1 Gene

Ripply1 homolog (zebrafish):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RIPPLY1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RIPPLY1 Gene

No ASD Table

Relevant External Links for RIPPLY1 Gene

GeneLoc Exon Structure for
RIPPLY1
ECgene alternative splicing isoforms for
RIPPLY1

Expression for RIPPLY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIPPLY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIPPLY1 Gene

This gene is overexpressed in Liver (x16.4) and Kidney - Cortex (x12.7).

NURSA nuclear receptor signaling pathways regulating expression of RIPPLY1 Gene:

RIPPLY1

SOURCE GeneReport for Unigene cluster for RIPPLY1 Gene:

Hs.334726
genes like me logo Genes that share expression patterns with RIPPLY1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPPLY1 Gene

Orthologs for RIPPLY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPPLY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIPPLY1 33 34
  • 98.4 (n)
cow
(Bos Taurus)
Mammalia RIPPLY1 33 34
  • 82.47 (n)
dog
(Canis familiaris)
Mammalia RIPPLY1 34
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ripply1 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIPPLY1 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ripply1 34
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for RIPPLY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIPPLY1 Gene

ENSEMBL:
Gene Tree for RIPPLY1 (if available)
TreeFam:
Gene Tree for RIPPLY1 (if available)

Paralogs for RIPPLY1 Gene

Paralogs for RIPPLY1 Gene

(1) SIMAP similar genes for RIPPLY1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RIPPLY1: view

Variants for RIPPLY1 Gene

Sequence variations from dbSNP and Humsavar for RIPPLY1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000070618 -- 106,904,302(+) TTTGC(C/T)AGAAA intron-variant, upstream-variant-2KB
rs1000505782 -- 106,903,857(+) AAAAG(G/T)GGCAT intron-variant, upstream-variant-2KB
rs1001571426 -- 106,904,892(+) AGCGT(A/G)CAGAG intron-variant, upstream-variant-2KB
rs1001587558 -- 106,901,658(+) CTCTG(G/T)GACCC intron-variant
rs1002208261 -- 106,903,950(+) ATTTG(C/T)CAAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RIPPLY1 Gene

Variant ID Type Subtype PubMed ID
esv2752312 CNV gain 17911159

Variation tolerance for RIPPLY1 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIPPLY1 Gene

Human Gene Mutation Database (HGMD)
RIPPLY1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPPLY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPPLY1 Gene

Disorders for RIPPLY1 Gene

Relevant External Links for RIPPLY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIPPLY1

No disorders were found for RIPPLY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIPPLY1 Gene

Publications for RIPPLY1 Gene

  1. Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. (PMID: 16326386) Kawamura A … Takada S (Developmental cell 2005) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  4. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. (PMID: 23143602) Whitcomb DC … Devlin B (Nature genetics 2012) 3 60
  5. Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite. (PMID: 20346937) Takahashi J … Takada S (Developmental biology 2010) 3 60

Products for RIPPLY1 Gene

Sources for RIPPLY1 Gene

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