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Aliases for RIPOR3 Gene

Aliases for RIPOR3 Gene

  • RIPOR Family Member 3 2 3
  • Family With Sequence Similarity 65 Member C 2 3 5
  • FAM65C 3 4 5
  • C20orf175 3 4
  • Family With Sequence Similarity 65, Member C 2
  • Chromosome 20 Open Reading Frame 175 2
  • Chromosome 20 Open Reading Frame 176 2
  • Protein FAM65C 3
  • C20orf176 3

External Ids for RIPOR3 Gene

Previous HGNC Symbols for RIPOR3 Gene

  • C20orf175
  • C20orf176
  • FAM65C

Summaries for RIPOR3 Gene

GeneCards Summary for RIPOR3 Gene

RIPOR3 (RIPOR Family Member 3) is a Protein Coding gene. An important paralog of this gene is RIPOR2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPOR3 Gene

Genomics for RIPOR3 Gene

Regulatory Elements for RIPOR3 Gene

Enhancers for RIPOR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G050721 2 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -43.2 -43182 27.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC RIPOR3 PARD6B BCAS4 MIR645 ENSG00000232043 MOCS3 PIR40975
GH20G050658 1.7 Ensembl ENCODE dbSUPER 12.6 +30.4 30393 6.5 CREB3L1 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000232043 DPM1 RIPOR3 MOCS3 RPL36P2 MIR1302-5 MIR645 PSMD10P1 BCAS4 LOC105372659
GH20G050757 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -69.1 -69072 7.8 HNRNPUL1 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS PARD6B BCAS4 RIPOR3 DPM1 PIR40975
GH20G050641 1.6 Ensembl ENCODE dbSUPER 11.6 +47.5 47501 6.2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 RPL36P2 MIR1302-5 RIPOR3 RNF114 LOC100506175
GH20G050766 1.4 Ensembl ENCODE dbSUPER 10.6 -75.5 -75543 1.3 HDGF PKNOX1 ARNT NFXL1 ZBTB40 RAD21 RARA TCF12 ZNF143 BCLAF1 BCAS4 RIPOR3 PARD6B PIR40975
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIPOR3 on UCSC Golden Path with GeneCards custom track

Promoters for RIPOR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000138547 404 401 HDGF PKNOX1 ATF1 CREB3L1 ARNT SIN3A YY1 TCF12 ZNF766 ELK1

Genomic Location for RIPOR3 Gene

Chromosome:
20
Start:
50,586,108 bp from pter
End:
50,692,004 bp from pter
Size:
105,897 bases
Orientation:
Minus strand

Genomic View for RIPOR3 Gene

Genes around RIPOR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPOR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPOR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPOR3 Gene

Proteins for RIPOR3 Gene

  • Protein details for RIPOR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MK2-FA65C_HUMAN
    Recommended name:
    Protein FAM65C
    Protein Accession:
    Q96MK2
    Secondary Accessions:
    • Q5QPB6
    • Q9NQQ2

    Protein attributes for RIPOR3 Gene

    Size:
    946 amino acids
    Molecular mass:
    105290 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RIPOR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPOR3 Gene

Post-translational modifications for RIPOR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIPOR3 Gene

Domains & Families for RIPOR3 Gene

Protein Domains for RIPOR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RIPOR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96MK2

UniProtKB/Swiss-Prot:

FA65C_HUMAN :
  • Belongs to the FAM65 family.
Family:
  • Belongs to the FAM65 family.
genes like me logo Genes that share domains with RIPOR3: view

No data available for Gene Families for RIPOR3 Gene

Function for RIPOR3 Gene

genes like me logo Genes that share phenotypes with RIPOR3: view

Animal Model Products

miRNA for RIPOR3 Gene

miRTarBase miRNAs that target RIPOR3

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIPOR3 Gene

Localization for RIPOR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPOR3 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIPOR3 Gene

Pathways & Interactions for RIPOR3 Gene

SuperPathways for RIPOR3 Gene

No Data Available

Interacting Proteins for RIPOR3 Gene

Gene Ontology (GO) - Biological Process for RIPOR3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RIPOR3 Gene

Drugs & Compounds for RIPOR3 Gene

No Compound Related Data Available

Transcripts for RIPOR3 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIPOR3 Gene

No ASD Table

Relevant External Links for RIPOR3 Gene

GeneLoc Exon Structure for
RIPOR3
ECgene alternative splicing isoforms for
RIPOR3

Expression for RIPOR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of RIPOR3 Gene:

RIPOR3
genes like me logo Genes that share expression patterns with RIPOR3: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPOR3 Gene

Orthologs for RIPOR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIPOR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM65C 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia FAM65C 34 35
  • 87.6 (n)
cow
(Bos Taurus)
Mammalia FAM65C 34 35
  • 84.81 (n)
rat
(Rattus norvegicus)
Mammalia Fam65c 34
  • 79.82 (n)
mouse
(Mus musculus)
Mammalia Fam65c 34 16 35
  • 79.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM65C 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM65C 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM65C 34 35
  • 59.96 (n)
lizard
(Anolis carolinensis)
Reptilia FAM65C 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam65c 34
  • 61.83 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:113070 34
  • 52.05 (n)
FAM65C 35
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C27H2.2 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for RIPOR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIPOR3 Gene

ENSEMBL:
Gene Tree for RIPOR3 (if available)
TreeFam:
Gene Tree for RIPOR3 (if available)

Paralogs for RIPOR3 Gene

Paralogs for RIPOR3 Gene

genes like me logo Genes that share paralogs with RIPOR3: view

Variants for RIPOR3 Gene

Sequence variations from dbSNP and Humsavar for RIPOR3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs141033220 Uncertain significance 50,630,793(+) GCCCA(C/T)GACCC nc-transcript-variant, reference, missense
rs1000036390 -- 50,612,329(+) AGCCA(C/T)AGACA intron-variant
rs1000077916 -- 50,614,377(+) TCCTC(A/G)CTTTC intron-variant, downstream-variant-500B
rs1000078272 -- 50,601,870(+) CTTAA(A/T)ATCTT intron-variant
rs1000160007 -- 50,641,228(+) TTTCT(A/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIPOR3 Gene

Variant ID Type Subtype PubMed ID
esv1002485 CNV deletion 20482838
esv1006667 CNV deletion 20482838
esv1383548 CNV insertion 17803354
esv2667883 CNV deletion 23128226
esv2722503 CNV deletion 23290073
esv3646045 CNV loss 21293372
nsv1124835 CNV duplication 24896259
nsv1131595 CNV deletion 24896259
nsv834001 CNV loss 17160897
nsv979439 CNV duplication 23825009

Variation tolerance for RIPOR3 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIPOR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPOR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPOR3 Gene

Disorders for RIPOR3 Gene

Relevant External Links for RIPOR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIPOR3

No disorders were found for RIPOR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIPOR3 Gene

Publications for RIPOR3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 64
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for RIPOR3 Gene

Sources for RIPOR3 Gene

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