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Aliases for RIPOR1 Gene

Aliases for RIPOR1 Gene

  • RHO Family Interacting Cell Polarization Regulator 1 2 3
  • Family With Sequence Similarity 65 Member A 2 3 5
  • FAM65A 3 4 5
  • Family With Sequence Similarity 65, Member A 2
  • Protein FAM65A 3
  • KIAA1930 4

External Ids for RIPOR1 Gene

Previous HGNC Symbols for RIPOR1 Gene

  • FAM65A

Summaries for RIPOR1 Gene

GeneCards Summary for RIPOR1 Gene

RIPOR1 (RHO Family Interacting Cell Polarization Regulator 1) is a Protein Coding gene. An important paralog of this gene is RIPOR2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPOR1 Gene

Genomics for RIPOR1 Gene

Regulatory Elements for RIPOR1 Gene

Enhancers for RIPOR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G067479 1.7 FANTOM5 ENCODE dbSUPER 13.7 -36.4 -36366 5.0 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 SIN3A ARID4B FEZF1 DMAP1 ATP6V0D1 ACD ZDHHC1 ENKD1 SLC7A6OS RIPOR1 CARMIL2 C16orf86 ENSG00000259797 HSD11B2
GH16G067545 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +29.7 29671 5.3 HDGF ARNT WRNIP1 ARID4B ZNF2 YY1 ZNF121 ZNF143 SP5 REST HSD11B2 CARMIL2 ATP6V0D1 RIPOR1 ACD PARD6A ENSG00000237718 C16orf86 ENKD1 DPEP2
GH16G067486 1.6 Ensembl ENCODE dbSUPER 12.1 -28.9 -28890 6.2 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ATP6V0D1 RIPOR1 LRRC36 CARMIL2 ZDHHC1 HSD11B2 ENSG00000237718 PARD6A ACD PRMT7
GH16G067555 1.5 Ensembl ENCODE dbSUPER 12.4 +37.9 37891 2.0 ZNF493 ZFP64 ZNF121 KLF7 FOS ZNF202 REST ZNF623 ZNF518A ZNF292 ZDHHC1 ENSG00000260465 CENPT ACD ENKD1 E2F4 KIAA0895L ENSG00000263276 FBXL8 ENSG00000270165
GH16G067854 1.7 FANTOM5 Ensembl ENCODE 10 +338.8 338758 4.4 FOXA2 PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 RANBP10 ACD NRN1L TSNAXIP1 DUS2 PSKH1 PARD6A RIPOR1 PRMT7 SLC7A6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIPOR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIPOR1 Gene

Chromosome:
16
Start:
67,518,418 bp from pter
End:
67,546,788 bp from pter
Size:
28,371 bases
Orientation:
Plus strand

Genomic View for RIPOR1 Gene

Genes around RIPOR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPOR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPOR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPOR1 Gene

Proteins for RIPOR1 Gene

  • Protein details for RIPOR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS17-FA65A_HUMAN
    Recommended name:
    Protein FAM65A
    Protein Accession:
    Q6ZS17
    Secondary Accessions:
    • B4DEQ9
    • B4DIM2
    • E9PBS3
    • Q4G0A4
    • Q7Z5R7
    • Q8NDA4
    • Q96J39
    • Q96PV8
    • Q9H8D9

    Protein attributes for RIPOR1 Gene

    Size:
    1223 amino acids
    Molecular mass:
    132308 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14678.1; Type=Erroneous termination; Positions=256; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAB67823.1; Type=Frameshift; Positions=579; Evidence={ECO:0000305};

    Alternative splice isoforms for RIPOR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPOR1 Gene

Post-translational modifications for RIPOR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIPOR1 Gene

Domains & Families for RIPOR1 Gene

Protein Domains for RIPOR1 Gene

Suggested Antigen Peptide Sequences for RIPOR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZS17

UniProtKB/Swiss-Prot:

FA65A_HUMAN :
  • Belongs to the FAM65 family.
Family:
  • Belongs to the FAM65 family.
genes like me logo Genes that share domains with RIPOR1: view

No data available for Gene Families for RIPOR1 Gene

Function for RIPOR1 Gene

Gene Ontology (GO) - Molecular Function for RIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 27807006
GO:0071889 14-3-3 protein binding IDA 27807006
genes like me logo Genes that share ontologies with RIPOR1: view
genes like me logo Genes that share phenotypes with RIPOR1: view

Animal Model Products

miRNA for RIPOR1 Gene

miRTarBase miRNAs that target RIPOR1

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIPOR1 Gene

Localization for RIPOR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPOR1 Gene

Cytoplasm. Note=Localizes to the podocyte major processes and cell body. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPOR1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IBA --
GO:0005794 Golgi apparatus IDA 27807006
GO:0012506 vesicle membrane TAS 27807006
GO:0016020 membrane IDA 27807006
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with RIPOR1: view

Pathways & Interactions for RIPOR1 Gene

SuperPathways for RIPOR1 Gene

No Data Available

Interacting Proteins for RIPOR1 Gene

Gene Ontology (GO) - Biological Process for RIPOR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction IMP 27807006
GO:0008150 biological_process ND --
GO:0009267 cellular response to starvation IMP 27807006
GO:0009611 response to wounding IMP 27807006
GO:0030335 positive regulation of cell migration IMP 27807006
genes like me logo Genes that share ontologies with RIPOR1: view

No data available for Pathways by source and SIGNOR curated interactions for RIPOR1 Gene

Drugs & Compounds for RIPOR1 Gene

No Compound Related Data Available

Transcripts for RIPOR1 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIPOR1 Gene

No ASD Table

Relevant External Links for RIPOR1 Gene

GeneLoc Exon Structure for
RIPOR1
ECgene alternative splicing isoforms for
RIPOR1

Expression for RIPOR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of RIPOR1 Gene:

RIPOR1

Evidence on tissue expression from TISSUES for RIPOR1 Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with RIPOR1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPOR1 Gene

Orthologs for RIPOR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIPOR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM65A 35 34
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM65A 35 34
  • 87.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM65A 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam65a 34
  • 83.01 (n)
mouse
(Mus musculus)
Mammalia Fam65a 16 35 34
  • 82.77 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM65A 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM65A 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM65A 35 34
  • 70.68 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM65A 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam65a 34
  • 61.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20882 34
zebrafish
(Danio rerio)
Actinopterygii fam65a 35 34
  • 63.99 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C27H2.2 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for RIPOR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIPOR1 Gene

ENSEMBL:
Gene Tree for RIPOR1 (if available)
TreeFam:
Gene Tree for RIPOR1 (if available)

Paralogs for RIPOR1 Gene

Paralogs for RIPOR1 Gene

genes like me logo Genes that share paralogs with RIPOR1: view

Variants for RIPOR1 Gene

Sequence variations from dbSNP and Humsavar for RIPOR1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000190522 -- 67,532,917(+) GGAGG(C/T)CCCTC intron-variant
rs1000329784 -- 67,536,829(+) CAATC(A/G)GCACC intron-variant, upstream-variant-2KB
rs1000458619 -- 67,529,648(+) CCCTG(A/C)GTCCG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000510276 -- 67,531,427(+) CAGGC(C/G)CTAAA intron-variant, upstream-variant-2KB
rs1000578530 -- 67,531,896(+) CTGTT(C/G/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIPOR1 Gene

Variant ID Type Subtype PubMed ID
esv29734 CNV loss 19812545
esv3329286 CNV insertion 20981092
esv3638889 CNV loss 21293372
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv827711 CNV gain 20364138
nsv833266 CNV loss 17160897

Variation tolerance for RIPOR1 Gene

Residual Variation Intolerance Score: 8.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIPOR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPOR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPOR1 Gene

Disorders for RIPOR1 Gene

Relevant External Links for RIPOR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIPOR1

No disorders were found for RIPOR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIPOR1 Gene

Publications for RIPOR1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. RHO binding to FAM65A regulates Golgi reorientation during cell migration. (PMID: 27807006) Mardakheh F.K. … Marshall C.J. (J. Cell. Sci. 2016) 3 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for RIPOR1 Gene

Sources for RIPOR1 Gene

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