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Aliases for RIPK4 Gene

Aliases for RIPK4 Gene

  • Receptor Interacting Serine/Threonine Kinase 4 2 3 5
  • PKC-Delta-Interacting Protein Kinase 2 3 4
  • Receptor-Interacting Serine-Threonine Kinase 4 2 3
  • Ankyrin Repeat Domain-Containing Protein 3 3 4
  • Protein Kinase C-Associated Kinase 2 3
  • EC 4 63
  • ANKRD3 3 4
  • DIK 3 4
  • Serine/Threonine-Protein Kinase ANKRD3 3
  • Ankyrin Repeat Domain 3 2
  • EC 2.7.11 63
  • ANKK2 3
  • NKRD3 3
  • PPS2 3
  • RIP4 3
  • PKK 3

External Ids for RIPK4 Gene

Previous HGNC Symbols for RIPK4 Gene

  • ANKRD3

Previous GeneCards Identifiers for RIPK4 Gene

  • GC00U917001
  • GC21M042032
  • GC21M043159
  • GC21M028579

Summaries for RIPK4 Gene

Entrez Gene Summary for RIPK4 Gene

  • The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIPK4 Gene

RIPK4 (Receptor Interacting Serine/Threonine Kinase 4) is a Protein Coding gene. Diseases associated with RIPK4 include Popliteal Pterygium Syndrome 2, Lethal Type and Clear Cell Adenoma. Among its related pathways are NF-kappaB Signaling and Wnt / Hedgehog / Notch. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RIPK2.

UniProtKB/Swiss-Prot for RIPK4 Gene

  • Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.

Gene Wiki entry for RIPK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPK4 Gene

Genomics for RIPK4 Gene

Regulatory Elements for RIPK4 Gene

Enhancers for RIPK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RIPK4 on UCSC Golden Path with GeneCards custom track

Promoters for RIPK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RIPK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIPK4 Gene

41,739,369 bp from pter
41,767,106 bp from pter
27,738 bases
Minus strand

Genomic View for RIPK4 Gene

Genes around RIPK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPK4 Gene

Proteins for RIPK4 Gene

  • Protein details for RIPK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor-interacting serine/threonine-protein kinase 4
    Protein Accession:
    Secondary Accessions:
    • Q96KH0

    Protein attributes for RIPK4 Gene

    832 amino acids
    Molecular mass:
    91611 Da
    Quaternary structure:
    • Interacts with PRKCB (By similarity). Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.

    Alternative splice isoforms for RIPK4 Gene


neXtProt entry for RIPK4 Gene

Proteomics data for RIPK4 Gene at MOPED

Selected DME Specific Peptides for RIPK4 Gene

Post-translational modifications for RIPK4 Gene

  • May be phosphorylated by MAP3K2 and MAP3K3.
  • Polyubiquitinated with Lys-48 and Lys-63-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
  • Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426.
  • Ubiquitination at Lys 51 and Lys 145
  • Modification sites at PhosphoSitePlus

Other Protein References for RIPK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RIPK4 (ANKRD3)
  • Abcam antibodies for RIPK4

Domains & Families for RIPK4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
  • Contains 10 ANK repeats.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
  • Contains 10 ANK repeats.
genes like me logo Genes that share domains with RIPK4: view

Function for RIPK4 Gene

Molecular function for RIPK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.

Enzyme Numbers (IUBMB) for RIPK4 Gene

Gene Ontology (GO) - Molecular Function for RIPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with RIPK4: view
genes like me logo Genes that share phenotypes with RIPK4: view

Human Phenotype Ontology for RIPK4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RIPK4 Gene

MGI Knock Outs for RIPK4:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targets and HOMER Transcription for RIPK4 Gene

Localization for RIPK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPK4 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for RIPK4 Gene COMPARTMENTS Subcellular localization image for RIPK4 gene
Compartment Confidence
cytosol 4
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for RIPK4 Gene

Pathways & Interactions for RIPK4 Gene

genes like me logo Genes that share pathways with RIPK4: view

Pathways by source for RIPK4 Gene

2 Cell Signaling Technology pathways for RIPK4 Gene

Gene Ontology (GO) - Biological Process for RIPK4 Gene


No data available for SIGNOR curated interactions for RIPK4 Gene

Drugs & Compounds for RIPK4 Gene

(2) Drugs for RIPK4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RIPK4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RIPK4: view

Transcripts for RIPK4 Gene

mRNA/cDNA for RIPK4 Gene

Unigene Clusters for RIPK4 Gene

Receptor-interacting serine-threonine kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIPK4 Gene

No ASD Table

Relevant External Links for RIPK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIPK4 Gene

mRNA expression in normal human tissues for RIPK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIPK4 Gene

This gene is overexpressed in Esophagus - Mucosa (x12.0).

Protein differential expression in normal tissues from HIPED for RIPK4 Gene

This gene is overexpressed in Bone (36.5) and Urine (32.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIPK4 Gene

SOURCE GeneReport for Unigene cluster for RIPK4 Gene Hs.517310

genes like me logo Genes that share expression patterns with RIPK4: view

Protein tissue co-expression partners for RIPK4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RIPK4 Gene

Orthologs for RIPK4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RIPK4 35
  • 86.65 (n)
  • 89.92 (a)
RIPK4 36
  • 90 (a)
(Canis familiaris)
Mammalia RIPK4 35
  • 86.58 (n)
  • 89.28 (a)
RIPK4 36
  • 90 (a)
(Mus musculus)
Mammalia Ripk4 35
  • 84.91 (n)
  • 90.69 (a)
Ripk4 16
Ripk4 36
  • 90 (a)
(Pan troglodytes)
Mammalia RIPK4 35
  • 98.94 (n)
  • 99.36 (a)
RIPK4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ripk4 35
  • 84.86 (n)
  • 90.56 (a)
(Monodelphis domestica)
Mammalia RIPK4 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia RIPK4 36
  • 81 (a)
(Gallus gallus)
Aves RIPK4 35
  • 72.61 (n)
  • 77.52 (a)
RIPK4 36
  • 75 (a)
(Anolis carolinensis)
Reptilia RIPK4 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ripk4 35
  • 69.4 (n)
  • 71.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia ankrd3-prov 35
(Danio rerio)
Actinopterygii Dr.18839 35
ripk4 35
  • 64.4 (n)
  • 63.28 (a)
ripk4 36
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for RIPK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIPK4 Gene

Gene Tree for RIPK4 (if available)
Gene Tree for RIPK4 (if available)

Paralogs for RIPK4 Gene

Paralogs for RIPK4 Gene

(14) SIMAP similar genes for RIPK4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RIPK4: view

Variants for RIPK4 Gene

Sequence variations from dbSNP and Humsavar for RIPK4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
VAR_030160 -
rs12482626 - 41,751,190(+) CCATG(C/T)TGAGG reference, missense
VAR_041050 -
rs55645753 - 41,741,950(+) GGACA(C/T)GATGG reference, missense
rs55829311 - 41,741,653(+) CCCGT(A/T)CTGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RIPK4 Gene

Variant ID Type Subtype PubMed ID
nsv913760 CNV Loss 21882294
nsv459265 CNV Loss 19166990
dgv4743n71 CNV Gain 21882294
nsv913766 CNV Gain 21882294

Variation tolerance for RIPK4 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.80; 79.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIPK4 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPK4 Gene

Disorders for RIPK4 Gene

MalaCards: The human disease database

(7) MalaCards diseases for RIPK4 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
popliteal pterygium syndrome 2, lethal type
  • multiple pterygium syndrome aslan type
clear cell adenoma
keratinizing squamous cell carcinoma
  • keratinizing epidermoid carcinoma
popliteal pterygium syndrome 1
  • popliteal pterygium syndrome
chronic cervicitis
- elite association - COSMIC cancer census association via MalaCards
Search RIPK4 in MalaCards View complete list of genes associated with diseases


  • Popliteal pterygium syndrome, lethal type (PPS-L) [MIM:263650]: An autosomal recessive disorder characterized by multiple popliteal pterygia leading to severe arthrogryposis, ankyloblepharon filiforme adnatum, filiform bands between the jaws, synostosis of the carpal/tarsal and phalangeal bones in the hands and feet, digital hypoplasia/aplasia, complete soft-tissue syndactyly, lack of nails, lack of scalp hair, eyebrows and eyelashes, blepharophimosis, cleft lip and/or palate, and hypoplastic external genitalia. Early lethality is common, although survival into childhood and beyond has been reported. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RIPK4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RIPK4: view

No data available for Genatlas for RIPK4 Gene

Publications for RIPK4 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3 4 67
  2. Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells. (PMID: 18025152) Kim S.W. … Zhao J. (Blood 2008) 3 23
  3. Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair. (PMID: 17039240) Adams S. … Munz B. (J. Invest. Dermatol. 2007) 3 23
  4. Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner. (PMID: 12676934) Moran S.T. … Pillai S. (J. Biol. Chem. 2003) 3 23
  5. RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. (PMID: 12446564) Meylan E. … Tschopp J. (EMBO Rep. 2002) 3 23

Products for RIPK4 Gene

Sources for RIPK4 Gene