Aliases for RIPK4 Gene
External Ids for RIPK4 Gene
Previous HGNC Symbols for RIPK4 Gene
Previous GeneCards Identifiers for RIPK4 Gene
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
GeneCards Summary for RIPK4 Gene
RIPK4 (Receptor-Interacting Serine-Threonine Kinase 4) is a Protein Coding gene. Diseases associated with RIPK4 include popliteal pterygium syndrome 2, lethal type and keratinizing squamous cell carcinoma. Among its related pathways are Wnt / Hedgehog / Notch and NF-kappaB Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RIPK3.
UniProtKB/Swiss-Prot for RIPK4 Gene
Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.