Aliases for RIPK4 Gene
Aliases for RIPK4 Gene
- Receptor Interacting Serine/Threonine Kinase 4 2 3 5
- PKC-Delta-Interacting Protein Kinase 2 3 4
- Receptor-Interacting Serine-Threonine Kinase 4 2 3
- Ankyrin Repeat Domain-Containing Protein 3 3 4
- Protein Kinase C-Associated Kinase 2 3
- EC 2.7.11.1 4 63
- ANKRD3 3 4
- DIK 3 4
- Serine/Threonine-Protein Kinase ANKRD3 3
External Ids for RIPK4 Gene
- HGNC: 496
- Entrez Gene: 54101
- Ensembl: ENSG00000183421
- OMIM: 605706
- UniProtKB: P57078
Previous HGNC Symbols for RIPK4 Gene
- ANKRD3
Previous GeneCards Identifiers for RIPK4 Gene
- GC00U917001
- GC21M042032
- GC21M043159
- GC21M028579
Summaries for RIPK4 Gene
-
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
GeneCards Summary for RIPK4 Gene
RIPK4 (Receptor Interacting Serine/Threonine Kinase 4) is a Protein Coding gene. Diseases associated with RIPK4 include Popliteal Pterygium Syndrome 2, Lethal Type and Clear Cell Adenoma. Among its related pathways are NF-kappaB Signaling and Wnt / Hedgehog / Notch. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RIPK2.
UniProtKB/Swiss-Prot for RIPK4 Gene
-
Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPK4 Gene
Genomics for RIPK4 Gene
Regulatory Elements for RIPK4 Gene
Enhancers for RIPK4 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around RIPK4 on UCSC Golden Path with GeneCards custom track
Promoters for RIPK4 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around RIPK4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for RIPK4 Gene
- Chromosome:
- 21
- Start:
- 41,739,369 bp from pter
- End:
- 41,767,106 bp from pter
- Size:
- 27,738 bases
- Orientation:
- Minus strand
Genomic View for RIPK4 Gene
Genes around RIPK4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by Ensembl
- 21q22.3 by Entrez Gene
- 21q22.3 by HGNC
RIPK4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RIPK4 Gene
Proteins for RIPK4 Gene
-
Protein details for RIPK4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P57078-RIPK4_HUMAN
- Recommended name:
- Receptor-interacting serine/threonine-protein kinase 4
- Protein Accession:
- P57078
- Q96KH0
Protein attributes for RIPK4 Gene
- Size:
- 832 amino acids
- Molecular mass:
- 91611 Da
- Quaternary structure:
-
- Interacts with PRKCB (By similarity). Interacts with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4.
Protein Expression for RIPK4 Gene
Post-translational modifications for RIPK4 Gene
- May be phosphorylated by MAP3K2 and MAP3K3.
- Polyubiquitinated with Lys-48 and Lys-63-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
- Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426.
- Ubiquitination at Lys 51 and Lys 145
- Modification sites at PhosphoSitePlus
Other Protein References for RIPK4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for RIPK4 (ANKRD3)
- Novus Biologicals Antibodies for RIPK4
- Abcam antibodies for RIPK4
- Invitrogen Antibodies for RIPK4
- antibodies-online Antibodies for RIPK4: See all 61
- GeneTex RIPK4 antibody for RIPK4
-
Santa Cruz Biotechnology (SCBT) Antibodies for RIPK4
Protein Products
-
OriGene Purified Proteins for RIPK4
- Search Origene for MassSpec and Protein Over-expression Lysates for RIPK4
- Origene Custom Protein Services for RIPK4
- Novus Biologicals proteins for RIPK4
- antibodies-online Proteins for RIPK4: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RIPK4
- Abcam proteins for RIPK4
Assay Products
Domains & Families for RIPK4 Gene
Gene Families for RIPK4 Gene
Protein Domains for RIPK4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RIPK4 Gene
Graphical View of Domain Structure for InterPro Entry
P57078UniProtKB/Swiss-Prot:
RIPK4_HUMAN :- Contains 1 protein kinase domain.
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
- Contains 10 ANK repeats.
- Domain:
-
- Contains 1 protein kinase domain.
- Family:
-
- Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
- Similarity:
-
- Contains 10 ANK repeats.
Function for RIPK4 Gene
Molecular function for RIPK4 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot Function:
- Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.
Enzyme Numbers (IUBMB) for RIPK4 Gene
- EC 2.7.11 63
- EC 2.7.11.1 63 4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
Phenotypes for RIPK4 Gene
- MGI mutant phenotypes for RIPK4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RIPK4:
-
- Increased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Decreased substrate adherent cell growth
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Decreased viability
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Synthetic lethal with gemcitabine
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for RIPK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RIPK4 gene
- Search ViGene Biosciences for RIPK4
CRISPR Products
-
OriGene CRISPR knockouts for RIPK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for RIPK4
- GenScript: Design CRISPR guide RNA sequences for RIPK4
miRNA for RIPK4 Gene
- miRTarBase miRNAs that target RIPK4
miRNA Products
- Search ViGene Biosciences for RIPK4
Clone Products
- OriGene clones in human for RIPK4
- OriGene ORF clones in human,mouse,rat for RIPK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RIPK4
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RIPK4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RIPK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RIPK4 gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for RIPK4 Gene
Localization for RIPK4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RIPK4 Gene
- Cytoplasm. Membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| nucleus | 2 |
| extracellular | 1 |
No data available for Gene Ontology (GO) - Cellular Components for RIPK4 Gene
Pathways & Interactions for RIPK4 Gene
More details on SuperPathways for RIPK4| Superpath | Contained pathways | |
|---|---|---|
| 1 | NF-kappaB Signaling | |
| 2 | Wnt / Hedgehog / Notch |
Pathways by source for RIPK4 Gene
2 Cell Signaling Technology pathways for RIPK4 Gene
Interacting Proteins for RIPK4 Gene
Selected Interacting proteins:
ENSP00000332454
P57078-RIPK4_HUMAN
for RIPK4 Gene via
STRING
UniProtKB
I2D
No data available for SIGNOR curated interactions for RIPK4 Gene
Transcripts for RIPK4 Gene
mRNA/cDNA for RIPK4 Gene
- (1) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (66) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RIPK4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RIPK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for RIPK4
- GenScript: Design CRISPR guide RNA sequences for RIPK4
miRNA Products
- Search ViGene Biosciences for RIPK4
Clone Products
- OriGene clones in human for RIPK4
- OriGene ORF clones in human,mouse,rat for RIPK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RIPK4
Flow Cytometry Products
Expression for RIPK4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
- Renal Collecting Duct System
- Ureteric Bud
- S-shaped Body
-
Blood (Hematopoietic System)
- Common Dendritic Cell Precursors Hematopoietic Bone Marrow
- Double Positive Thymocytes Thymus
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
- Notochord
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Epithelial Cells
- Dental Placode Cells Dental Placode
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Lung (Respiratory System)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for RIPK4 Gene
This gene is overexpressed in Esophagus - Mucosa (x12.0).
This gene is overexpressed in Bone (36.5) and Urine (32.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIPK4 Gene
SOURCE GeneReport for Unigene cluster for RIPK4 Gene Hs.517310
Primer Products
-
OriGene qPCR primer pairs for RIPK4
No data available for mRNA Expression by UniProt/SwissProt for RIPK4 Gene
Orthologs for RIPK4 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | RIPK4 35 |
|
||
| RIPK4 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | RIPK4 35 |
|
||
| RIPK4 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ripk4 35 |
|
||
| Ripk4 16 |
|
||||
| Ripk4 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | RIPK4 35 |
|
||
| RIPK4 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ripk4 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RIPK4 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RIPK4 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RIPK4 35 |
|
||
| RIPK4 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | RIPK4 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ripk4 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | ankrd3-prov 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.18839 35 |
|
||
| ripk4 35 |
|
||||
| ripk4 36 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for RIPK4:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for RIPK4 Gene
(14) SIMAP similar genes for RIPK4 Gene using alignment to 3 proteins:
Variants for RIPK4 Gene
| SNP ID | Clin | Chr 21 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_030160 | - | ||||
| rs12482626 | - | 41,751,190(+) | CCATG(C/T)TGAGG | reference, missense | |
| VAR_041050 | - | ||||
| rs55645753 | - | 41,741,950(+) | GGACA(C/T)GATGG | reference, missense | |
| rs55829311 | - | 41,741,653(+) | CCCGT(A/T)CTGGG | reference, missense |
Residual Variation Intolerance Score:
12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.80;
79.10% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RIPK4 Gene
- Human Gene Mutation Database (HGMD)
- RIPK4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPK4 Gene
Disorders for RIPK4 Gene
(7) MalaCards diseases for RIPK4 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| popliteal pterygium syndrome 2, lethal type |
|
|
| clear cell adenoma |
|
|
| keratinizing squamous cell carcinoma |
|
|
| popliteal pterygium syndrome 1 |
|
|
| chronic cervicitis |
|
|
Search RIPK4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RIPK4_HUMAN- Popliteal pterygium syndrome, lethal type (PPS-L) [MIM:263650]: An autosomal recessive disorder characterized by multiple popliteal pterygia leading to severe arthrogryposis, ankyloblepharon filiforme adnatum, filiform bands between the jaws, synostosis of the carpal/tarsal and phalangeal bones in the hands and feet, digital hypoplasia/aplasia, complete soft-tissue syndactyly, lack of nails, lack of scalp hair, eyebrows and eyelashes, blepharophimosis, cleft lip and/or palate, and hypoplastic external genitalia. Early lethality is common, although survival into childhood and beyond has been reported. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for RIPK4
No data available for Genatlas for RIPK4 Gene
Publications for RIPK4 Gene
- The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3 4 67
- Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells. (PMID: 18025152) Kim S.W. … Zhao J. (Blood 2008) 3 23
- Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair. (PMID: 17039240) Adams S. … Munz B. (J. Invest. Dermatol. 2007) 3 23
- Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner. (PMID: 12676934) Moran S.T. … Pillai S. (J. Biol. Chem. 2003) 3 23
- RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. (PMID: 12446564) Meylan E. … Tschopp J. (EMBO Rep. 2002) 3 23
Products for RIPK4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Assay Services
- OriGene Purified Proteins for RIPK4
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- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for RIPK4
- Browse OriGene Inhibitory RNA Products For RIPK4
- OriGene qPCR primer pairs for RIPK4
- OriGene CRISPR knockouts for RIPK4
- OriGene clones in human for RIPK4
- OriGene ORF clones in human,mouse,rat for RIPK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for RIPK4
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- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for RIPK4
- Cell Signaling Technology (CST) Antibodies for RIPK4 (ANKRD3)
- Search for Antibodies & Assays
- Novus Biologicals Antibodies for RIPK4
- Novus Biologicals proteins for RIPK4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for RIPK4
- Abcam proteins for RIPK4
- Search for Assays for RIPK4 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Addgene plasmids for RIPK4
- antibodies-online Antibodies for RIPK4: See all 61
- Search antibodies-online for kits
- antibodies-online Proteins for RIPK4: See all 5
- Search antibodies-online for peptides
- GeneTex RIPK4 antibody for RIPK4
- Search GeneTex for Proteins for RIPK4
- ViGene Biosciences adenoviral particle packaged cDNA for RIPK4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RIPK4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RIPK4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RIPK4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RIPK4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RIPK4 gene
- Search ViGene Biosciences for RIPK4
- Search ViGene Biosciences for RIPK4
- Santa Cruz Biotechnology (SCBT) Antibodies for RIPK4
- Search Santa Cruz Biotechnology (SCBT) for RIPK4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RIPK4
Sources for RIPK4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon