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Aliases for RIPK3 Gene

Aliases for RIPK3 Gene

  • Receptor Interacting Serine/Threonine Kinase 3 2 3 5
  • RIP-Like Protein Kinase 3 3 4
  • RIP-3 3 4
  • RIP3 3 4
  • Receptor-Interacting Serine/Threonine-Protein Kinase 3 3
  • Receptor-Interacting Serine-Threonine Kinase 3 2
  • Receptor Interacting Protein 3 3
  • Receptor-Interacting Protein 3 4
  • EC 2.7.11.1 4

External Ids for RIPK3 Gene

Previous GeneCards Identifiers for RIPK3 Gene

  • GC14M022177
  • GC14M018592
  • GC14M022795
  • GC14M023875
  • GC14M024811
  • GC14M004920

Summaries for RIPK3 Gene

Entrez Gene Summary for RIPK3 Gene

  • The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIPK3 Gene

RIPK3 (Receptor Interacting Serine/Threonine Kinase 3) is a Protein Coding gene. Among its related pathways are Necroptosis and Activated TLR4 signalling. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is RIPK4.

UniProtKB/Swiss-Prot for RIPK3 Gene

  • Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Gene Wiki entry for RIPK3 Gene

Additional gene information for RIPK3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPK3 Gene

Genomics for RIPK3 Gene

Regulatory Elements for RIPK3 Gene

Enhancers for RIPK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H024333 1 ENCODE 26.7 +5.5 5536 2 ARID4B SIN3A ZNF121 SLC30A9 ZNF143 ZNF207 RUNX3 SP3 MXD4 NFYC RIPK3 LTB4R ADCY4 PIR32510
GH14H024364 1.4 ENCODE dbSUPER 14.8 -28.0 -27962 6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B YY1 SDR39U1 ADCY4 RIPK3 NGDN NYNRIN JPH4 NFATC4 CBLN3 KHNYN TGM1
GH14H024328 0.8 Ensembl ENCODE 22.4 +10.4 10383 1 L3MBTL2 EGR1 POLR2A NBN USF2 MGA EGR2 RIPK3 ADCY4 LTB4R DHRS1 PIR32510
GH14H024343 1.1 ENCODE dbSUPER 16 -3.8 -3848 1 FOXA2 MLX ARID4B BATF RAD21 THRB RARA YY1 MIXL1 MXD4 RIPK3 SLC22A17 TSSK4 THTPA MDP1 NYNRIN NGDN GC14M024354 ENSG00000283290
GH14H024377 1 ENCODE dbSUPER 16 -38.1 -38054 1 HDGF PKNOX1 KLF1 KLF17 ZFHX2 ZNF316 NFYB ATF7 EGR2 RFX1 ADCY4 RIPK3 NYNRIN KHNYN CBLN3 LTB4R NFATC4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIPK3 on UCSC Golden Path with GeneCards custom track

Promoters for RIPK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066863 345 601 MAZ NR2F1 ELF1 NR2F2 POLR2A IKZF1 NBN MLLT1 ZBTB33 EZH2

Transcription factor binding sites by QIAGEN in the RIPK3 gene promoter:

Genomic Location for RIPK3 Gene

Chromosome:
14
Start:
24,336,021 bp from pter
End:
24,340,045 bp from pter
Size:
4,025 bases
Orientation:
Minus strand

Genomic View for RIPK3 Gene

Genes around RIPK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPK3 Gene

Proteins for RIPK3 Gene

  • Protein details for RIPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y572-RIPK3_HUMAN
    Recommended name:
    Receptor-interacting serine/threonine-protein kinase 3
    Protein Accession:
    Q9Y572
    Secondary Accessions:
    • B4DJL9
    • C4AM87
    • Q5J795
    • Q5J796
    • Q6P5Y1

    Protein attributes for RIPK3 Gene

    Size:
    518 amino acids
    Molecular mass:
    56887 Da
    Quaternary structure:
    • Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts with MLKL; the interaction is direct. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with ARHGEF2.

    Alternative splice isoforms for RIPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPK3 Gene

Post-translational modifications for RIPK3 Gene

  • Polyubiquitinated with Lys-48 and Lys-63-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
  • RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3. Phosphorylation at Ser-227 is required for binding MLKL.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIPK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RIPK3 Gene

Domains & Families for RIPK3 Gene

Gene Families for RIPK3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RIPK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y572

UniProtKB/Swiss-Prot:

RIPK3_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with RIPK3: view

Function for RIPK3 Gene

Molecular function for RIPK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Enzyme Numbers (IUBMB) for RIPK3 Gene

Phenotypes From GWAS Catalog for RIPK3 Gene

Gene Ontology (GO) - Molecular Function for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 10339433
GO:0004672 protein kinase activity IMP,TAS 22265414
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004704 NF-kappaB-inducing kinase activity IEA --
GO:0005515 protein binding IPI 19524512
genes like me logo Genes that share ontologies with RIPK3: view
genes like me logo Genes that share phenotypes with RIPK3: view

Animal Models for RIPK3 Gene

MGI Knock Outs for RIPK3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RIPK3
  • Applied Biological Materials Clones for RIPK3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RIPK3 Gene

Localization for RIPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPK3 Gene

Cytoplasm, cytosol. Cell membrane. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPK3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
mitochondrion 4
nucleus 3
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RIPK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RIPK3 Gene

Pathways & Interactions for RIPK3 Gene

genes like me logo Genes that share pathways with RIPK3: view

Pathways by source for RIPK3 Gene

SIGNOR curated interactions for RIPK3 Gene

Activates:

Gene Ontology (GO) - Biological Process for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001914 regulation of T cell mediated cytotoxicity ISS --
GO:0002819 regulation of adaptive immune response ISS --
GO:0006464 cellular protein modification process TAS 10358032
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 10339433
genes like me logo Genes that share ontologies with RIPK3: view

Drugs & Compounds for RIPK3 Gene

(3) Drugs for RIPK3 Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pulmonary Surfactants Pharma 117
Respiratory System Agents Pharma 5122
ATP Nutra Agonist 0

(1) Additional Compounds for RIPK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with RIPK3: view

Transcripts for RIPK3 Gene

Unigene Clusters for RIPK3 Gene

Receptor-interacting serine-threonine kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RIPK3
  • Applied Biological Materials Clones for RIPK3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RIPK3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for RIPK3 Gene

GeneLoc Exon Structure for
RIPK3
ECgene alternative splicing isoforms for
RIPK3

Expression for RIPK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIPK3 Gene

mRNA differential expression in normal tissues according to GTEx for RIPK3 Gene

This gene is overexpressed in Whole Blood (x9.7).

Protein differential expression in normal tissues from HIPED for RIPK3 Gene

This gene is overexpressed in CD8 Tcells (25.7), Monocytes (9.1), Peripheral blood mononuclear cells (8.5), and NK cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIPK3 Gene



Protein tissue co-expression partners for RIPK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RIPK3 Gene:

RIPK3

SOURCE GeneReport for Unigene cluster for RIPK3 Gene:

Hs.268551

mRNA Expression by UniProt/SwissProt for RIPK3 Gene:

Q9Y572-RIPK3_HUMAN
Tissue specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.

Evidence on tissue expression from TISSUES for RIPK3 Gene

  • Blood(4.4)
  • Nervous system(4.2)
  • Lung(2.6)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with RIPK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPK3 Gene

Orthologs for RIPK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIPK3 33 34
  • 98.91 (n)
cow
(Bos Taurus)
Mammalia RIPK3 33 34
  • 80.43 (n)
dog
(Canis familiaris)
Mammalia RIPK3 33 34
  • 74.84 (n)
mouse
(Mus musculus)
Mammalia Ripk3 33 16 34
  • 71.24 (n)
rat
(Rattus norvegicus)
Mammalia Ripk3 33
  • 70.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 13 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490493 33
  • 49.01 (n)
zebrafish
(Danio rerio)
Actinopterygii ripk3l 33 34
  • 50.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
ManyToMany
Species where no ortholog for RIPK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIPK3 Gene

ENSEMBL:
Gene Tree for RIPK3 (if available)
TreeFam:
Gene Tree for RIPK3 (if available)

Paralogs for RIPK3 Gene

Paralogs for RIPK3 Gene

genes like me logo Genes that share paralogs with RIPK3: view

Variants for RIPK3 Gene

Sequence variations from dbSNP and Humsavar for RIPK3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs114872465 Uncertain significance 24,337,408(+) ACTCT(A/C/G)GGATA reference, missense
rs1000226345 -- 24,338,724(+) GCCTT(A/G)TGGTA intron-variant
rs1000305647 -- 24,336,474(+) ATGAA(A/G)TCTCT intron-variant, upstream-variant-2KB
rs1000568844 -- 24,337,345(+) TACGA(C/G)AGTGC reference, missense
rs1000676766 -- 24,337,673(+) CTGGG(A/G)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIPK3 Gene

Variant ID Type Subtype PubMed ID
nsv564060 CNV loss 21841781

Variation tolerance for RIPK3 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIPK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPK3 Gene

Disorders for RIPK3 Gene

Relevant External Links for RIPK3

Genetic Association Database (GAD)
RIPK3
Human Genome Epidemiology (HuGE) Navigator
RIPK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIPK3

No disorders were found for RIPK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIPK3 Gene

Publications for RIPK3 Gene

  1. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. (PMID: 20354226) Vandenabeele P … Vanden Berghe T (Science signaling 2010) 3 4 22 60
  2. RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. (PMID: 15896315) Yang Y … Wu M (Biochemical and biophysical research communications 2005) 3 4 22 60
  3. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PMID: 11734559) Sun X … Dixit VM (The Journal of biological chemistry 2002) 3 4 22 60
  4. RIP3, a novel apoptosis-inducing kinase. (PMID: 10358032) Sun X … Dixit VM (The Journal of biological chemistry 1999) 2 3 4 60
  5. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. (PMID: 10339433) Yu PW … Luo Y (Current biology : CB 1999) 2 3 4 60

Products for RIPK3 Gene

  • Addgene plasmids for RIPK3

Sources for RIPK3 Gene

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