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Aliases for RIPK3 Gene

Aliases for RIPK3 Gene

  • Receptor-Interacting Serine-Threonine Kinase 3 2 3
  • RIP3 3 4 6
  • Receptor-Interacting Protein 3 3 4
  • RIP-Like Protein Kinase 3 3 4
  • RIP-3 3 4
  • Receptor-Interacting Serine/Threonine-Protein Kinase 3 3
  • Receptor Interacting Protein 3 3
  • EC 2.7.11.1 4

External Ids for RIPK3 Gene

Previous GeneCards Identifiers for RIPK3 Gene

  • GC14M022177
  • GC14M018592
  • GC14M022795
  • GC14M023875
  • GC14M024811
  • GC14M004920

Summaries for RIPK3 Gene

Entrez Gene Summary for RIPK3 Gene

  • The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIPK3 Gene

RIPK3 (Receptor-Interacting Serine-Threonine Kinase 3) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and Apoptosis and Autophagy. GO annotations related to this gene include identical protein binding and transcription coactivator activity. An important paralog of this gene is RIPK2.

UniProtKB/Swiss-Prot for RIPK3 Gene

  • Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Gene Wiki entry for RIPK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPK3 Gene

Genomics for RIPK3 Gene

Regulatory Elements for RIPK3 Gene

Transcription factor binding sites by QIAGEN in the RIPK3 gene promoter:

Genomic Location for RIPK3 Gene

Start:
24,336,021 bp from pter
End:
24,340,045 bp from pter
Size:
4,025 bases
Orientation:
Minus strand

Genomic View for RIPK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPK3 Gene

Proteins for RIPK3 Gene

  • Protein details for RIPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y572-RIPK3_HUMAN
    Recommended name:
    Receptor-interacting serine/threonine-protein kinase 3
    Protein Accession:
    Q9Y572
    Secondary Accessions:
    • B4DJL9
    • C4AM87
    • Q5J795
    • Q5J796
    • Q6P5Y1

    Protein attributes for RIPK3 Gene

    Size:
    518 amino acids
    Molecular mass:
    56887 Da
    Quaternary structure:
    • Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts with MLKL; the interaction is direct. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with ARHGEF2.

    Alternative splice isoforms for RIPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPK3 Gene

Proteomics data for RIPK3 Gene at MOPED

Post-translational modifications for RIPK3 Gene

  • Polyubiquitinated with Lys-48 and Lys-63-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
  • RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the necroptotic function of RIPK3. Phosphorylation at Ser-227 is required for binding MLKL.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIPK3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RIPK3 Gene

Domains for RIPK3 Gene

Protein Domains for RIPK3 Gene

Suggested Antigen Peptide Sequences for RIPK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y572

UniProtKB/Swiss-Prot:

RIPK3_HUMAN :
  • Q9Y572
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with RIPK3: view

Function for RIPK3 Gene

Molecular function for RIPK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Enzyme Numbers (IUBMB) for RIPK3 Gene

Gene Ontology (GO) - Molecular Function for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 10339433
GO:0004672 protein kinase activity IMP 22265414
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004704 NF-kappaB-inducing kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with RIPK3: view
genes like me logo Genes that share phenotypes with RIPK3: view

Animal Models for RIPK3 Gene

MGI Knock Outs for RIPK3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIPK3

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for RIPK3 Gene

Localization for RIPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPK3 Gene

Cytoplasm, cytosol. Cell membrane. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIPK3 Gene COMPARTMENTS Subcellular localization image for RIPK3 gene
Compartment Confidence
cytosol 4
mitochondrion 3
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0097342 ripoptosome IEA --
genes like me logo Genes that share ontologies with RIPK3: view

Pathways for RIPK3 Gene

genes like me logo Genes that share pathways with RIPK3: view

Pathways by source for RIPK3 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for RIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001914 regulation of T cell mediated cytotoxicity ISS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0002819 regulation of adaptive immune response ISS --
GO:0006464 cellular protein modification process TAS 10358032
genes like me logo Genes that share ontologies with RIPK3: view

Compounds for RIPK3 Gene

(2) HMDB Compounds for RIPK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with RIPK3: view

Transcripts for RIPK3 Gene

Unigene Clusters for RIPK3 Gene

Receptor-interacting serine-threonine kinase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIPK3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RIPK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIPK3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for RIPK3 Gene

GeneLoc Exon Structure for
RIPK3
ECgene alternative splicing isoforms for
RIPK3

Expression for RIPK3 Gene

mRNA expression in normal human tissues for RIPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIPK3 Gene

This gene is overexpressed in Whole Blood (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIPK3 Gene

SOURCE GeneReport for Unigene cluster for RIPK3 Gene Hs.268551

mRNA Expression by UniProt/SwissProt for RIPK3 Gene

Q9Y572-RIPK3_HUMAN
Tissue specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
genes like me logo Genes that share expressions with RIPK3: view

In Situ Assay Products

Orthologs for RIPK3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIPK3 35
  • 98.91 (n)
  • 98.65 (a)
RIPK3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RIPK3 35
  • 80.43 (n)
  • 73.91 (a)
RIPK3 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIPK3 35
  • 74.84 (n)
  • 62.58 (a)
RIPK3 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ripk3 35
  • 71.24 (n)
  • 62.66 (a)
Ripk3 16
Ripk3 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ripk3 35
  • 70.89 (n)
  • 61.39 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 13 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490493 35
  • 49.01 (n)
  • 40.7 (a)
zebrafish
(Danio rerio)
Actinopterygii ripk3l 35
  • 50.54 (n)
  • 42.96 (a)
ripk3l 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
ManyToMany
Species with no ortholog for RIPK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIPK3 Gene

ENSEMBL:
Gene Tree for RIPK3 (if available)
TreeFam:
Gene Tree for RIPK3 (if available)

Paralogs for RIPK3 Gene

Paralogs for RIPK3 Gene

genes like me logo Genes that share paralogs with RIPK3: view

Variants for RIPK3 Gene

Sequence variations from dbSNP and Humsavar for RIPK3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1007380 -- 24,340,468(-) cttag(G/T)caagg upstream-variant-2KB
rs1007381 -- 24,340,405(-) CAGTA(C/T)CTATC upstream-variant-2KB
rs1950501 -- 24,337,594(-) TATGC(A/C/G)TTGAC intron-variant
rs3181247 -- 24,339,182(-) GCTCC(C/T)TGTCG synonymous-codon, reference
rs3181248 -- 24,338,962(-) TGCTC(C/T)AGCCA intron-variant

Relevant External Links for RIPK3 Gene

HapMap Linkage Disequilibrium report
RIPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RIPK3 Gene

Disorders for RIPK3 Gene

(2) Novoseek inferred disease relationships for RIPK3 Gene

Disease -log(P) Hits PubMed IDs
necrosis 33.3 7
tumors 10.6 2

Relevant External Links for RIPK3

Genetic Association Database (GAD)
RIPK3
Human Genome Epidemiology (HuGE) Navigator
RIPK3
genes like me logo Genes that share disorders with RIPK3: view

No data available for UniProtKB/Swiss-Prot for RIPK3 Gene

Publications for RIPK3 Gene

  1. RIP3 beta and RIP3 gamma, two novel splice variants of receptor- interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. (PMID: 15896315) Yang Y. … Wu M. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  2. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. (PMID: 20354226) Vandenabeele P. … Vanden Berghe T. (Sci. Signal. 2010) 3 4 23
  3. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. (PMID: 10339433) Yu P.W. … Luo Y. (Curr. Biol. 1999) 2 3 4
  4. RIP3, a novel apoptosis-inducing kinase. (PMID: 10358032) Sun X. … Dixit V.M. (J. Biol. Chem. 1999) 2 3 4
  5. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PMID: 11734559) Sun X. … Dixit V.M. (J. Biol. Chem. 2002) 3 4 23

Products for RIPK3 Gene

  • Addgene plasmids for RIPK3

Sources for RIPK3 Gene

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