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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIPK3 Gene

protein-coding   GIFtS: 65
GCID: GC14M024811

Receptor-Interacting Serine-Threonine Kinase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Receptor-Interacting Serine-Threonine Kinase 31 2     RIP-Like Protein Kinase 32 3
RIP32 3 5     Receptor Interacting Protein 32
Receptor-Interacting Protein 32 3     Receptor-Interacting Serine/Threonine-Protein Kinase 32
RIP-32 3     EC 2.7.11.13

External Ids:    HGNC: 100211   Entrez Gene: 110352   Ensembl: ENSG000001294657   OMIM: 6058175   UniProtKB: Q9Y5723   

Export aliases for RIPK3 gene to outside databases

Previous GC identifers: GC14M022177 GC14M018592 GC14M022795 GC14M023875 GC14M004920


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIPK3 Gene:
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein
kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is
predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear
localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling
complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RIPK3 Gene: 
RIPK3 (receptor-interacting serine-threonine kinase 3) is a protein-coding gene. Diseases associated with RIPK3 include hodgkin's lymphoma, and non-hodgkin lymphoma, and among its related super-pathways are Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways and Cytosolic sensors of pathogen-associated DNA . GO annotations related to this gene include transcription coactivator activity and identical protein binding. An important paralog of this gene is RIPK1.

UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572
Function: Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction
of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to
and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may
eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced
ROS production (By similarity)

Gene Wiki entry for RIPK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIPK3 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIPK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIPK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

RIPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIPK3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024811:  view genomic region     (about GC identifiers)

Start:
24,805,227 bp from pter      End:
24,809,251 bp from pter
Size:
4,025 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572 (See protein sequence)
Recommended Name: Receptor-interacting serine/threonine-protein kinase 3  
Size: 518 amino acids; 56887 Da
Subunit: Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this
interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon
TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex
leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Binds TRAF2 and is recruited to the
TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these
metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Mitochondrion (Potential)
Secondary accessions: B4DJL9 C4AM87 Q5J795 Q5J796 Q6P5Y1
Alternative splicing: 3 isoforms:  Q9Y572-1   Q9Y572-2   Q9Y572-3   

Explore the universe of human proteins at neXtProt for RIPK3: NX_Q9Y572

Explore proteomics data for RIPK3 at MOPED 

Post-translational modifications:

  • UniProtKB: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the
    necroptotic function of RIPK3
  • UniProtKB: Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation
    of NF-kappa-B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y572

  • RIPK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIPK3 Protein Expression
    REFSEQ proteins: NP_006862.2  
    ENSEMBL proteins: 
     ENSP00000216274   ENSP00000452328   ENSP00000451840  
    Reactome Protein details: Q9Y572
    Human Recombinant Protein Products for RIPK3: 
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    OriGene Protein Over-expression Lysate for RIPK3
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    Novus Biologicals RIPK3 Proteins
    Novus Biologicals RIPK3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIPK3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    RIPK3 for ontologies           About GeneDecksing



    RIPK3 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for RIPK3 
    Cloud-Clone Corp. CLIAs for RIPK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: receptor-interacting serine-threonine kinase 3 
    Receptor interacting protein kinase (RIPK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR025735 RHIM_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y572

    ProtoNet protein and cluster: Q9Y572

    UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    RIPK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIPK3_HUMAN, Q9Y572
    Function: Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction
    of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to
    and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may
    eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced
    ROS production (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS10339433
    GO:0004672protein kinase activity TAS10358032
    GO:0004674protein serine/threonine kinase activity TAS10339433
    GO:0004704NF-kappaB-inducing kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    RIPK3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RIPK3:
     Increased colony dispersion (i  Increased mitotic index 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ripk3):
     cellular  digestive/alimentary  endocrine/exocrine gland  immune system  mortality/aging 

    RIPK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RIPK3: Ripk3tm1Xidw Ripk3tm1Vmd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIPK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIPK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIPK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIPK3 

    miRNA
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    hsa-miR-223
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RIPK3 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    2Cytosolic DNA-sensing pathway
    Cytosolic DNA-sensing pathway0.36
    Cytosolic sensors of pathogen-associated DNA 0.36
    3TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86
    4RIP-mediated NFkB activation via ZBP1
    RIP-mediated NFkB activation via ZBP10.85
    ZBP1(DAI) mediated induction of type I IFNs0.85
    5Immune System
    Immune System0.56
    Innate Immune System0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RIPK3
        Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RIPK3
        Toll-Like Receptors Pathway

    2 Cell Signaling Technology (CST) Pathways for RIPK3
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for RIPK3
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    1 BioSystems Pathway for RIPK3
        TNF-alpha/NF-kB Signaling Pathway

    2 Sino Biological Pathways for RIPK3 
        TNF Signaling
    Death Receptor Signaling

    5/12        Reactome Pathways for RIPK3 (see all 12)
        ZBP1(DAI) mediated induction of type I IFNs
    Cytosolic sensors of pathogen-associated DNA
    Toll Like Receptor 4 (TLR4) Cascade
    Toll-Like Receptors Cascades
    TRIF-mediated programmed cell death


    2         Kegg Pathways  (Kegg details for RIPK3):
        Cytosolic DNA-sensing pathway
    TNF signaling pathway


    RIPK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/129 Interacting proteins for RIPK3 (Q9Y5721, 2, 3 ENSP000002162744) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-49126 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49126 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49126 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49126 I2D: score=2 
    ENSG00000232421P074372, 3MINT-49126 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006464cellular protein modification process TAS10358032
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS10339433

    RIPK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIPK3

    2 HMDB Compounds for RIPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about RIPK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIPK3 gene: 
    NM_006871.3  

    Unigene Cluster for RIPK3:

    Receptor-interacting serine-threonine kinase 3
    Hs.268551  [show with all ESTs]
    Unigene Representative Sequence: NM_006871
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216274(uc001wpa.3 uc001wpb.3 uc010alq.3 uc010toi.2)
    ENST00000554756 ENST00000554569 ENST00000557624(uc010toj.1) ENST00000557253
    ENST00000554338 ENST00000557662
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    Additional mRNA sequence: 

    AF156884.1 AK075275.1 AK296140.1 AK296309.1 AY453693.1 AY494983.1 BC062584.1 

    6 DOTS entries:

    DT.95161019  DT.100788565  DT.95291610  DT.454742  DT.100844051  DT.92425143 

    24/159 AceView cDNA sequences (see all 159):

    CK725043 AA491389 AI394293 BC062584 AL045082 AW085656 AF086230 BI819557 
    BU607712 BX248285 AK131333 CA748745 CA308180 AA044828 CD370547 AW009940 
    CA975912 BQ880215 CA305961 BI838468 BQ003425 AW207417 AA054849 AK126468 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RIPK3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                          -                       -                                             
    SP2:                          -                                                                     
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for RIPK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAATGCT
    RIPK3 Expression
    About this image


    See RIPK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIPK3

    SOURCE GeneReport for Unigene cluster: Hs.268551

    UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572
    Tissue specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and
    kidney. Isoform 3 is significantly increased in colon and lung cancers

        SABiosciences Expression via Pathway-Focused PCR Arrays including RIPK3: 
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RIPK3 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ripk31 , 5 receptor-interacting serine-threonine kinase 31, 5 71.45(n)1
    62.87(a)1
      14 (28.19 cM)5
    565321  NM_019955.21  NP_064339.21 
     557849965 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    34(a)
    32(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039011(677-9420)
    GL343220.1(631554-645384)
    zebrafish
    (Danio rerio)
    Actinopterygii ripk3l1 receptor-interacting serine-threonine kinase 3 like 50.66(n)
    42.6(a)
      100004555  XM_001343791.1  XP_001343827.1 


    ENSEMBL Gene Tree for RIPK3 (if available)
    TreeFam Gene Tree for RIPK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIPK3 gene
    RIPK12  RIPK42  RIPK22  ANKK12  

    RIPK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/188 SNPs in RIPK3 are shown (see all 188)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410494
    ----see VAR_0410492 P Q mis40--------
    rs1438962481,2
    F--24806300(+) ATTCCC/TTCGGG 2 R G mis11Minor allele frequency- T:0.00NA 4548
    rs1468867191,2
    C,F--24806303(+) CCCTCG/AGGGTC 2 /R /* stg12Minor allele frequency- A:0.00NA EU 5817
    rs1129734801,2
    C,F--24806331(+) GTTGAG/AGTAGG 2 /T syn13Minor allele frequency- A:0.00CSA WA NA 4768
    rs1389083601,2
    C--24806360(+) GAAAGG/TTGAGG 2 T P mis10--------
    rs2011210761,2
    C--24806366(+) TGAGGA/TCTCTG 2 T S mis10--------
    rs2001897831,2
    --24806414(+) GCCTGC/TTGTCC 2 T A mis10--------
    rs454538991,2
    C,F--24806431(+) GTGGAA/G/TCCTGC 3 D A V mis14NA NS EU 1583
    rs1430735021,2
    C--24806433(+) GGAACC/GTGCTC 2 H Q mis10--------
    rs1488516161,2
    C,F--24806513(+) ATTCAG/ATTTGT 2 /L syn12Minor allele frequency- A:0.00NA EU 5875

    HapMap Linkage Disequilibrium report for RIPK3 (24805227 - 24809251 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RIPK3: --

    Human Gene Mutation Database (HGMD): RIPK3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RIPK3
    DNA2.0 Custom Variant and Variant Library Synthesis for RIPK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605817    OMIM disorders: --

    5 diseases for RIPK3:    About MalaCards
    hodgkin's lymphoma    non-hodgkin lymphoma    obesity    hepatocellular carcinoma
    lung cancer


    RIPK3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RIPK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 33.3 12 19498109 (4), 20354226 (2), 15208320 (1)
    tumors 10.6 3 15208320 (1), 10818227 (1)

    Genetic Association Database (GAD): RIPK3
    Human Genome Epidemiology (HuGE) Navigator: RIPK3 (2 documents)

    Export disorders for RIPK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIPK3 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with RIPK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. (PubMed id 10339433)1, 2, 3 Yu P.W.... Luo Y. (1999)
    2. RIP3, a novel apoptosis-inducing kinase. (PubMed id 10358032)1, 2, 3 Sun X.... Dixit V.M. (1999)
    3. RIP3 beta and RIP3 gamma, two novel splice variants of receptor- interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. (PubMed id 15896315)1, 2, 9 Yang Y.... Wu M. (2005)
    4. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PubMed id 11734559)1, 2, 9 Sun X....Dixit V.M. (2002)
    5. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. (PubMed id 20354226)1, 2, 9 Vandenabeele P....Vanden Berghe T. (2010)
    6. cIAP1/2 are direct E3 ligases conjugating diverse typ es of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) . (PubMed id 21931591)1, 2 Bertrand M.J....Vandenabeele P. (2011)
    7. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    8. Receptor interacting protein kinase-3 determines cell ular necrotic response to TNF-alpha. (PubMed id 19524512)1, 2 He S....Wang X. (2009)
    9. Phosphorylation-driven assembly of the RIP1-RIP3 comp lex regulates programmed necrosis and virus-induced inflammation. (PubMed id 19524513)1, 2 Cho Y.S....Chan F.K. (2009)
    10. Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. (PubMed id 17827388)1, 4 Cerhan J.R....Slager S.L. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11035 HGNC: 10021 AceView: RIPK3andADCY4 Ensembl:ENSG00000129465 euGenes: HUgn11035
    ECgene: RIPK3 Kegg: 11035 H-InvDB: RIPK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIPK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RIPK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIPK3 gene:
    Search GeneIP for patents involving RIPK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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