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RIPK3 Gene

protein-coding   GIFtS: 65
GCID: GC14M024811

Receptor-Interacting Serine-Threonine Kinase 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Receptor-Interacting Serine-Threonine Kinase 31 2     RIP-Like Protein Kinase 32 3
RIP32 3 5     Receptor Interacting Protein 32
Receptor-Interacting Protein 32 3     Receptor-Interacting Serine/Threonine-Protein Kinase 32
RIP-32 3     EC 2.7.11.13

External Ids:    HGNC: 100211   Entrez Gene: 110352   Ensembl: ENSG000001294657   OMIM: 6058175   UniProtKB: Q9Y5723   

Export aliases for RIPK3 gene to outside databases

Previous GC identifers: GC14M022177 GC14M018592 GC14M022795 GC14M023875 GC14M004920


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RIPK3 Gene:
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein
kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is
predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear
localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling
complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RIPK3 Gene:
RIPK3 (receptor-interacting serine-threonine kinase 3) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and identical protein binding. An important paralog of this gene is RIPK4.

UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572
Function: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha
family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a
necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and
PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative
phosphorylation, which could result in enhanced ROS production

Gene Wiki entry for RIPK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RIPK3 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIPK3 promoter sequence
   Search Chromatin IP Primers for RIPK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

RIPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIPK3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024811:  view genomic region     (about GC identifiers)

Start:
24,805,227 bp from pter      End:
24,809,251 bp from pter
Size:
4,025 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572 (See protein sequence)
Recommended Name: Receptor-interacting serine/threonine-protein kinase 3  
Size: 518 amino acids; 56887 Da
Subunit: Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this
interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon
TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex
leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts with MLKL; the interaction
is direct. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1;
these interactions result in activation of these metabolic enzymes. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and
XIAP/BIRC4. Interacts with ARHGEF2
Secondary accessions: B4DJL9 C4AM87 Q5J795 Q5J796 Q6P5Y1
Alternative splicing: 3 isoforms:  Q9Y572-1   Q9Y572-2   Q9Y572-3   

Explore the universe of human proteins at neXtProt for RIPK3: NX_Q9Y572

Explore proteomics data for RIPK3 at MOPED

Post-translational modifications: 

  • RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in the
    necroptotic function of RIPK3. Phosphorylation at Ser-227 is required for binding MLKL1
  • Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation
    of NF-kappa-B1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RIPK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006862.2  
    ENSEMBL proteins: 
     ENSP00000216274   ENSP00000452328   ENSP00000451840  
    Reactome Protein details: Q9Y572

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    antibodies-online peptides for RIPK3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: receptor-interacting serine-threonine kinase 3
    Receptor interacting protein kinase (RIPK) family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR025735 RHIM_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y572

    ProtoNet protein and cluster: Q9Y572

    UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with RIPK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIPK3_HUMAN, Q9Y572
    Function: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha
    family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a
    necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and
    PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative
    phosphorylation, which could result in enhanced ROS production
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS10339433
    GO:0004672protein kinase activity IMP--
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004704NF-kappaB-inducing kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with RIPK3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RIPK3:
     Increased colony dispersion (i  Increased mitotic index 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ripk3):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  immune system  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with RIPK3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for RIPK3: Ripk3tm1Xidw Ripk3tm1Vmd

       genOway: Develop your customized and physiologically relevant rodent model for RIPK3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RIPK3_HUMAN, Q9Y572: Cytoplasm, cytosol. Cell membrane (By similarity). Mitochondrion (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion3
    nucleus2
    plasma membrane2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with RIPK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RIPK3 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cytosolic sensors of pathogen-associated DNA
    RIP-mediated NFkB activation via ZBP10.81
    Cytosolic sensors of pathogen-associated DNA0.38
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Cytosolic DNA-sensing pathway0.33
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    MyD88-independent cascade0.69
    TRIF-mediated programmed cell death0.00
    Toll Like Receptor 3 (TLR3) Cascade0.69
    3TNF Signaling
    TNF Signaling0.50
    Death Receptor Signaling0.50
    4TRAF Pathway
    Toll-Like Receptors Pathway0.41
    5NOD-like Receptor Signaling Pathways
    Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways0.33


    Find genes that share SuperPaths with RIPK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RIPK3
        Toll-Like Receptors Pathway

    2 Cell Signaling Technology (CST) Pathways for RIPK3
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for RIPK3
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    1 BioSystems Pathway for RIPK3
        TNF-alpha/NF-kB Signaling Pathway

    2 Sino Biological Pathways for RIPK3
        TNF Signaling
    Death Receptor Signaling

    3 Reactome Pathways for RIPK3
        IKK complex recruitment mediated by RIP1
    TRIF-mediated programmed cell death
    RIP-mediated NFkB activation via ZBP1


    2 Kegg Pathways  (Kegg details for RIPK3):
        Cytosolic DNA-sensing pathway
    TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RIPK3: 
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RIPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RIPK3 (Q9Y5721, 2, 3 ENSP000002162744) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-49126 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49126 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49126 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49126 I2D: score=2 
    ENSG00000232421P074372, 3MINT-49126 I2D: score=2 
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    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001914regulation of T cell mediated cytotoxicity ISS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0002819regulation of adaptive immune response ISS--
    GO:0006464cellular protein modification process TAS10358032

    Find genes that share ontologies with RIPK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for RIPK3

    2 HMDB Compounds for RIPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RIPK3 gene: 
    NM_006871.3  

    Unigene Cluster for RIPK3:

    Receptor-interacting serine-threonine kinase 3
    Hs.268551  [show with all ESTs]
    Unigene Representative Sequence: NM_006871
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216274(uc001wpa.3 uc001wpb.3 uc010alq.3 uc010toi.2)
    ENST00000554756 ENST00000554569 ENST00000557624(uc010toj.1) ENST00000557253
    ENST00000554338 ENST00000557662
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    Additional mRNA sequence: 

    AF156884.1 AK075275.1 AK296140.1 AK296309.1 AY453693.1 AY494983.1 BC062584.1 

    6 DOTS entries:

    DT.95161019  DT.100788565  DT.95291610  DT.454742  DT.100844051  DT.92425143 

    Selected AceView cDNA sequences (see all 159):

    AI394293 CB128397 CA310192 CA748745 BI765026 AA044828 CD370547 AI000839 
    BQ003425 BQ007090 BI833736 NM_006871 AW207417 BI838468 AF086230 AA054849 
    BC041668 AL045082 BX115914 CA305961 AK122714 BI819557 AW009940 CA308180 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RIPK3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                          -                       -                                             
    SP2:                          -                                                                     
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for RIPK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RIPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGAATGCT
    RIPK3 Expression
    About this image


    RIPK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RIPK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RIPK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268551

    UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572
    Tissue specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and
    kidney. Isoform 3 is significantly increased in colon and lung cancers

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RIPK3: 
              Apoptosis 384HT in human mouse rat
              Necrosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RIPK3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ripk31 , 5 receptor-interacting serine-threonine kinase 31, 5 71.24(n)1
    62.66(a)1
      14 (28.19 cM)5
    565321  NM_019955.21  NP_064339.21 
     557849965 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    13(a)
    many ↔ many
    11(2635483-2648522)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    34(a)
    32(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039011(677-9420)
    GL343220.1(631554-645384)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004904931 receptor-interacting serine/threonine-protein kinase more 49.01(n)
    40.7(a)
      100490493  XM_002937754.2  XP_002937800.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ripk3l1 receptor-interacting serine-threonine kinase 3 like 50.54(n)
    42.96(a)
      100004555  XM_001343791.2  XP_001343827.1 


    ENSEMBL Gene Tree for RIPK3 (if available)
    TreeFam Gene Tree for RIPK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RIPK3 gene
    RIPK42  RIPK12  RIPK22  ANKK12  

    Find genes that share paralogs with RIPK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RIPK3 (see all 188)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438962481,2
    F--24806300(+) ATTCCC/TTCGGG 2 R G mis11Minor allele frequency- T:0.00NA 4548
    rs1468867191,2
    C,F--24806303(+) CCCTCG/AGGGTC 2 /R /* stg12Minor allele frequency- A:0.00NA EU 5817
    rs1129734801,2
    C,F--24806331(+) GTTGAG/AGTAGG 2 /T syn13Minor allele frequency- A:0.00CSA WA NA 4768
    rs1389083601,2
    C--24806360(+) GAAAGG/TTGAGG 2 T P mis10--------
    rs2011210761,2
    C--24806366(+) TGAGGA/TCTCTG 2 T S mis10--------
    rs2001897831,2
    --24806414(+) GCCTGC/TTGTCC 2 T A mis10--------
    rs454538991,2
    C,F--24806431(+) GTGGAA/G/TCCTGC 3 D A V mis14NA NS EU 1583
    rs1430735021,2
    C--24806433(+) GGAACC/GTGCTC 2 H Q mis10--------
    rs1488516161,2
    C,F--24806513(+) ATTCAG/ATTTGT 2 /L syn12Minor allele frequency- A:0.00NA EU 5875
    rs1149707401,2
    C,F--24806525(+) TAGCCA/GCTCAG 2 R W mis12Minor allele frequency- G:0.01NA EA 422

    HapMap Linkage Disequilibrium report for RIPK3 (24805227 - 24809251 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RIPK3: --
    Human Gene Mutation Database (HGMD): RIPK3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RIPK3
    DNA2.0 Custom Variant and Variant Library Synthesis for RIPK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605817    OMIM disorders: --


    Find genes that share disorders with RIPK3           About GenesLikeMe

    2 Novoseek inferred disease relationships for RIPK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 33.3 12 19498109 (4), 20354226 (2), 15208320 (1)
    tumors 10.6 3 15208320 (1), 10818227 (1)

    Genetic Association Database (GAD): RIPK3
    Human Genome Epidemiology (HuGE) Navigator: RIPK3 (2 documents)

    Export disorders for RIPK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RIPK3 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with RIPK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. (PubMed id 10339433)1, 2, 3 Yu P.W.... Luo Y. (Curr. Biol. 1999)
    2. RIP3, a novel apoptosis-inducing kinase. (PubMed id 10358032)1, 2, 3 Sun X.... Dixit V.M. (J. Biol. Chem. 1999)
    3. RIP3 beta and RIP3 gamma, two novel splice variants of receptor- interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. (PubMed id 15896315)1, 2, 9 Yang Y.... Wu M. (Biochem. Biophys. Res. Commun. 2005)
    4. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PubMed id 11734559)1, 2, 9 Sun X.... Dixit V.M. (J. Biol. Chem. 2002)
    5. The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. (PubMed id 20354226)1, 2, 9 Vandenabeele P.... Vanden Berghe T. (Sci. Signal. 2010)
    6. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. (PubMed id 22421439)1, 2 Zhao J....Liu Z.G. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). (PubMed id 21931591)1, 2 Bertrand M.J.... Vandenabeele P. (PLoS ONE 2011)
    8. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    9. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. (PubMed id 19524512)1, 2 He S.... Wang X. (Cell 2009)
    10. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. (PubMed id 19524513)1, 2 Cho Y.S....Chan F.K. (Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11035 HGNC: 10021 AceView: RIPK3andADCY4 Ensembl:ENSG00000129465 euGenes: HUgn11035
    ECgene: RIPK3 Kegg: 11035 H-InvDB: RIPK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RIPK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RIPK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RIPK3 gene:
    Search GeneIP for patents involving RIPK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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