RIPK3 Gene
protein-coding GIFtS: 63
GCID: GC14M024811
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|
receptor-interacting serine-threonine kinase 3
| |
Aliases
for RIPK3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Receptor-Interacting Serine-Threonine Kinase 31 2 | | RIP-Like Protein Kinase 32 3 | | RIP31 2 3 5 | | Receptor Interacting Protein 32 | | Receptor-Interacting Protein 32 3 | | Receptor-Interacting Serine/Threonine-Protein Kinase 32 | | RIP-32 3 | | EC 2.7.11.13 |
Export aliases for RIPK3 gene to outside databasesPrevious GC identifers: GC14M022177 GC14M018592 GC14M022795 GC14M023875 GC14M004920 |
Summaries
for RIPK3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RIPK3:
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine proteinkinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantlylocalized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization andexport signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induceapoptosis and weakly activate the NF-kappaB transcription factor. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572Function: Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction ofnecrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to andenhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventuallystimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production(By similarity)
Gene Wiki entry for RIPK3
|
Genomic Views
for RIPK3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RIPK3 gene promoter:
AML1a STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RIPK3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPK3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q12RIPK3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M024811: view genomic region
(about GC identifiers)
Start:
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24,805,227 bp from pter |
End:
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24,809,251 bp from pter |
Size:
|
4,025 bases |
Orientation:
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minus strand |
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Proteins
for RIPK3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572 (See
protein sequence)Recommended Name: Receptor-interacting serine/threonine-protein kinase 3 Size: 518 amino acids; 56887 Da
Subunit: Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); thisinteraction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necrosis-inducing complex. Upon TNF-inducednecrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5phosphorylation and increase in PGAM5 phosphatase activity. Binds TRAF2 and is recruited to the TNFR-1 signalingcomplex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes.Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Mitochondrion (Potential)
Secondary accessions: B4DJL9 C4AM87 Q5J795 Q5J796 Q6P5Y1Alternative splicing: 3 isoforms: Q9Y572-1 Q9Y572-2 Q9Y572-3 Explore the universe of human proteins at neXtProt for RIPK3: NX_Q9Y572
Post-translational modifications:
RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-199 plays a role in thenecroptotic function of RIPK31
Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation ofNF-kappa-B1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y572
RIPK3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006862.2
ENSEMBL proteins: ENSP00000216274 ENSP00000452328 ENSP00000451840 Reactome Protein details: Q9Y572
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RIPK3 for ontologies About GeneDecksing
RIPK3 Antibody Products:
Assay Products for RIPK3: |
Protein
Domains /
Families
for RIPK3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RIPK3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y572ProtoNet protein and cluster: Q9Y572 UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for RIPK3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572Function: Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction ofnecrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to andenhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventuallystimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production(By similarity)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for RIPK3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK3 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
RIPK3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RIPK3:
Animal Models:
Mouse knock-outs for RIPK3: Ripk3tm1Xidw Ripk3tm1Vmd
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ripk3):
RIPK3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RIPK3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | RIP-mediated NFkB activation via DAI | | | 3 | Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway | | | 4 | Immune System | | | 5 | Apoptosis and Autophagy | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for RIPK3
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RIPK3
2 
Cell Signaling Technology (CST) Pathways for RIPK3
1  GeneGo (Thomson Reuters) Pathway for RIPK3
1  BioSystems Pathway for RIPK3
5/12 
Reactome Pathways for RIPK3 (see all 12)
1 
Kegg Pathway (Kegg details for RIPK3):
RIPK3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIPK3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/117 Interacting proteins for RIPK3 (Q9Y5721, 2, 3 ENSP000002162744) via UniProtKB, MINT, STRING, and/or I2D (see all 117)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
RIPK3 for ontologies About GeneDecksing
|
Drugs & Compounds
for RIPK3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RIPK3
2 HMDB Compounds for RIPK3 About this table
Search CenterWatch for drugs/clinical trials and news about RIPK3
|
Transcripts
for RIPK3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RIPK3 gene: NM_006871.3 Unigene Cluster for RIPK3: Receptor-interacting serine-threonine kinase 3 Hs.268551 [show with all ESTs]Unigene Representative Sequence: NM_0068717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000216274(uc001wpa.3 uc001wpb.3 uc010alq.3 uc010toi.2)
ENST00000554756 ENST00000554569 ENST00000557624(uc010toj.1) ENST00000557253
ENST00000554338 ENST00000557662
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RIPK3 (NM_006871) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIPK3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK3 |
Additional cDNA sequence: AF156884.1 AK075275.1 AK296140.1 AK296309.1 AY453693.1 AY494983.1 BC062584.1 6 DOTS entries: DT.95161019 DT.100788565 DT.95291610 DT.454742 DT.100844051 DT.92425143 24/159 AceView cDNA sequences (see all 159): AL045027 AK126468 AK075275 AF086230 AI000839 CK725043 CA748745 NM_006871 AW009940 BQ003425 AA491389 BI838468 CA975912 AF088070 AI394293 BX328885 BI819557 CA305961 BF001652 BQ880215 NM_139247 BX115914 CA310192 AW085656
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RIPK3 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RIPK3
|
Expression
for RIPK3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RIPK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGAATGCT
About this image
See RIPK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIPK3
SOURCE GeneReport for Unigene cluster: Hs.268551
UniProtKB/Swiss-Prot: RIPK3_HUMAN, Q9Y572Tissue specificity: Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney.Isoform 3 is significantly increased in colon and lung cancers
SABiosciences Expression via Pathway-Focused PCR Arrays including RIPK3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIPK3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIPK3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPK3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPK3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK3 |
Orthologs
for RIPK3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RIPK3 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for RIPK3 (if available)
TreeFam Gene Tree for RIPK3 (if available) |
Paralogs
for RIPK3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RIPK3 gene
- RIPK42 RIPK12 RIPK22 ANKK12
RIPK3 for paralogs About GeneDecksing
|
Genomic Variants
for RIPK3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RIPK3 (24805227 - 24809251 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RIPK3: --
Human Gene Mutation Database (HGMD): RIPK3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIPK3 |
|
Disorders
/ Diseases
for RIPK3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RIPK3 for disorders About GeneDecksing
OMIM gene information: 605817
OMIM disorders: --
7  diseases for RIPK3: About MalaCardsnon-hodgkin lymphoma hodgkin's lymphoma homocysteine hepatocellular carcinoma
lung cancer obesity carcinoma
2 Novoseek disease relationships for RIPK3 gene About this table
Human Genome Epidemiology (HuGE) Navigator: RIPK3 (2 documents)
Export disorders for RIPK3 gene to outside databases
|
Publications
for RIPK3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RIPK3 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with RIPK3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. (PubMed id 10339433)1, 2, 3 Yu P.W.... Luo Y. (1999)
- RIP3, a novel apoptosis-inducing kinase. (PubMed id 10358032)1, 2, 3 Sun X.... Dixit V.M. (1999)
- RIP3 beta and RIP3 gamma, two novel splice variants of receptor- interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. (PubMed id 15896315)1, 2, 9 Yang Y.... Wu M. (2005)
- Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PubMed id 11734559)1, 2, 9 Sun X....Dixit V.M. (2002)
- The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. (PubMed id 20354226)1, 2, 9 Vandenabeele P....Vanden Berghe T. (2010)
- cIAP1/2 are direct E3 ligases conjugating diverse typ es of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) . (PubMed id 21931591)1, 2 Bertrand M.J....Vandenabeele P. (2011)
- Receptor interacting protein kinase-3 determines cell ular necrotic response to TNF-alpha. (PubMed id 19524512)1, 2 He S....Wang X. (2009)
- Phosphorylation-driven assembly of the RIP1-RIP3 comp lex regulates programmed necrosis and virus-induced inflammation. (PubMed id 19524513)1, 2 Cho Y.S....Chan F.K. (2009)
- Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3. (PubMed id 15208320)1, 9 Yang Y....Wu M. (2004)
- Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703. (PubMed id 16844082)1, 9 Feng S....Wu M. (2006)
|
External Searches for RIPK3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RIPK3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RIPK3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RIPK3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RIPK3 gene:
Search GeneIP for patents involving RIPK3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RIPK3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIPK3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIPK3 | | | OriGene Protein Over-expression Lysate for RIPK3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RIPK3 | | OriGene 3'-UTR Clone for RIPK3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RIPK3 | | OriGene Custom Protein Services for RIPK3 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RIPK3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIPK3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPK3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIPK3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPK3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPK3 |
| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK3 |
|  |  |  | | | | ThermoFisher Antibodies for RIPK3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK3 |
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