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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIPK2 Gene

protein-coding   GIFtS: 71
GCID: GC08P090769

Receptor-Interacting Serine-Threonine Kinase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Receptor-Interacting Serine-Threonine Kinase 21 2     GIG302
Receptor-Interacting Protein 22 3     CARD-Carrying Kinase2
Tyrosine-Protein Kinase RIPK22 3     CARD-Containing Interleukin-1 Beta-Converting Enzyme (ICE)-Associated
Kinase2
CARDIAK2 3     Growth-Inhibiting Gene 302
RICK2 3     Receptor-Interacting Protein (RIP)-Like Interacting Caspase-Like Apoptosis
Regulatory Protein (CLARP) Kinase2
RIP-22 3     Receptor-Interacting Serine/Threonine-Protein Kinase 22
RIP22 3     EC 2.7.10.23
CARD-Containing IL-1 Beta ICE-Kinase2 3     CARD-Containing Interleukin-1 Beta-Converting Enzyme-Associated Kinase3
EC 2.7.11.13 8     RIP-Like-Interacting CLARP Kinase3
CARD32     EC 2.7.118
CCK2     

External Ids:    HGNC: 100201   Entrez Gene: 87672   Ensembl: ENSG000001043127   OMIM: 6034555   UniProtKB: O433533   

Export aliases for RIPK2 gene to outside databases

Previous GC identifers: GC08P089201 GC08P090502 GC08P090726 GC08P090839 GC08P085980


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIPK2 Gene:
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases.
The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of
signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and
inducer of apoptosis in response to various stimuli. (provided by RefSeq, Jul 2008)

GeneCards Summary for RIPK2 Gene: 
RIPK2 (receptor-interacting serine-threonine kinase 2) is a protein-coding gene. Diseases associated with RIPK2 include taylor's syndrome, and shigellosis, and among its related super-pathways are NOD1/2 Signaling Pathway and MAP kinase activation in TLR cascade. GO annotations related to this gene include protein homodimerization activity and signal transducer activity. An important paralog of this gene is RIPK3.

UniProtKB/Swiss-Prot: RIPK2_HUMAN, O43353
Function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive
immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and
recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked
polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the
recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and
subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates
into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth
control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in
promoting BCL10 phosphorylation and subsequent NF-kappa-B activation

summary for RIPK2 Gene:
Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and
gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells
and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of
biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK
receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin.
The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar
affinity for sulfated and non-sulfated forms.

Gene Wiki entry for RIPK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIPK2 gene promoter:
         AML1a   AP-1   ATF-2   LCR-F1   NF-kappaB   RORalpha2   FOXL1   c-Jun   Msx-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIPK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIPK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21

RIPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIPK2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P090769:  view genomic region     (about GC identifiers)

Start:
90,769,975 bp from pter      End:
90,803,292 bp from pter
Size:
33,318 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIPK2_HUMAN, O43353 (See protein sequence)
Recommended Name: Receptor-interacting serine/threonine-protein kinase 2  
Size: 540 amino acids; 61195 Da
Subunit: Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1,
TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex. Interacts with
NOD1 and NOD2. Interacts with MAP3K4; this interaction sequesters RIPK2 from the NOD2 signaling pathway.
Interacts with IKBKG/NEMO. The polyubiquitinated protein interacts with MAP3K7/TAK1. Interacts with XIAP/BIRC4.
Interacts with NLRP10
Subcellular location: Cytoplasm (Probable)
Secondary accessions: Q6UWF0
Alternative splicing: 2 isoforms:  O43353-1   O43353-2   

Explore the universe of human proteins at neXtProt for RIPK2: NX_O43353

Explore proteomics data for RIPK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated. Autophosphorylation at Tyr-474 is necessary for effective NOD2 signaling
  • UniProtKB: Ubiquitinated on Lys-209; undergoes 'Lys-63'-linked polyubiquitination catalyzed by ITCH. Polyubiquitinated with
    'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43353

  • 2 DME Specific Peptides for RIPK2 (O43353)
     YMPNGSL  WEVLSRKQPF 

    RIPK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIPK2 Protein Expression
    REFSEQ proteins: NP_003812.1  
    ENSEMBL proteins: 
     ENSP00000220751   ENSP00000429271   ENSP00000427736   ENSP00000441623  
    Reactome Protein details: O43353
    Human Recombinant Protein Products for RIPK2: 
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    OriGene Protein Over-expression Lysate for RIPK2
    OriGene MassSpec for RIPK2 
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    Novus Biologicals RIPK2 Proteins
    Novus Biologicals RIPK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIPK2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    RIPK2 for ontologies           About GeneDecksing



    RIPK2 Antibody Products: 
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    Abcam antibodies for RIPK2
    Cloud-Clone Corp. Antibodies for RIPK2 
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    LSBio Antibodies in human, mouse, rat for RIPK2 

    Assay Products for RIPK2: 
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    Cloud-Clone Corp. ELISAs for RIPK2 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: receptor-interacting serine-threonine kinase 2 
    Receptor interacting protein kinase (RIPK) family

    5/6 InterPro protein domains (see all 6):
     IPR011029 DEATH-like_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR017322 Rcpt-int_Ser/Thr_kinase-2

    Graphical View of Domain Structure for InterPro Entry O43353

    ProtoNet protein and cluster: O43353

    UniProtKB/Swiss-Prot: RIPK2_HUMAN, O43353
    Domain: Contains an N-terminal kinase domain and a C-terminal caspase activation and recruitment domain (CARD)
    that mediates the recruitment of CARD-containing proteins
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 CARD domain
    Similarity: Contains 1 protein kinase domain


    RIPK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIPK2_HUMAN, O43353
    Function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive
    immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and
    recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked
    polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein mediates the
    recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and
    subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates
    into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth
    control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in
    promoting BCL10 phosphorylation and subsequent NF-kappa-B activation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for RIPK2:
    receptor interacting serine-threonine kinase 2,widely expressed with two transcripts due to differential
    polyadenylation,regulator of TNFRSF6 (CD95)-mediated

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112 EC 2.7.10.21

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0004871signal transducer activity TAS9642260
         
    RIPK2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RIPK2:
     Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ripk2):
     cellular  digestive/alimentary  hematopoietic system  immune system 

    RIPK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RIPK2: Ripk2tm1Flv Ripk2tm1Cfl Ripk2tm1Ghc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIPK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIPK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIPK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIPK2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIPK2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate RIPK2:
    hsa-miR-135b hsa-miR-200c hsa-miR-429 hsa-miR-200b hsa-miR-135a
    SwitchGear 3'UTR luciferase reporter plasmidRIPK2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RIPK2 (NM_003821)
    Sino Biological Human cDNA Clone for RIPK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIPK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK2
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                         Customized lentivirus expression plasmids for stable overexpression of RIPK2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RIPK2 About   (see all 28)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.69
    NOD-like receptor signaling pathway0.37
    NOD1/2 Signaling Pathway0.69
    NOD pathway0.33
    2TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 5 (TLR5) Cascade0.93
    MyD88-independent cascade 0.87
    MyD88 cascade initiated on plasma membrane0.93
    Toll Like Receptor 3 (TLR3) Cascade0.87
    Toll Like Receptor 10 (TLR10) Cascade0.93
    Toll Like Receptor 4 (TLR4) Cascade0.87
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll-Like Receptors Cascades0.87
    3JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK10.58
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex0.56
    activated TAK1 mediates p38 MAPK activation0.58
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    5p75NTR signals via NF-kB
    p75NTR signals via NF-kB0.81
    p75NTR recruits signalling complexes0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RIPK2
        Transcription NF-kB signaling pathway

    1 R&D Systems Pathway for RIPK2
        NOD-like Receptor Signaling Pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RIPK2
        Caspase Cascade
    Toll-Like Receptors Pathway
    Fas Signaling

    2 Cell Signaling Technology (CST) Pathways for RIPK2
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for RIPK2
        Transcription NF-kB signaling pathway

    5/7 BioSystems Pathways for RIPK2 (see all 7)
        NOD pathway
    FAS pathway and Stress induction of HSP regulation
    TCR Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    p75(NTR)-mediated signaling


    5/37        Reactome Pathways for RIPK2 (see all 37)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex
    Toll Like Receptor 3 (TLR3) Cascade
    MyD88-independent cascade


    4         Kegg Pathways  (Kegg details for RIPK2):
        NOD-like receptor signaling pathway
    Neurotrophin signaling pathway
    Shigellosis
    Tuberculosis


    RIPK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIPK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/134 Interacting proteins for RIPK2 (O433531, 2, 3 ENSP000002207514) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-49068 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49068 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49068 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49068 I2D: score=2 
    ENSG00000232421P074372, 3MINT-49068 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/61 biological process terms (GO ID links to tree view) (see all 61):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity TAS--
    GO:0001961positive regulation of cytokine-mediated signaling pathway IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002250adaptive immune response ISS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--

    RIPK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RIPK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RIPK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CCK Octapeptide, sulfated C-terminal octapeptide of CCK[25126-32-3]
    CCK Octapeptide, non-sulfated Non-sulfated form of CCK octapeptide[25679-24-7]
    Proglumide sodium saltNon-selective CCK antagonist; orally active[99247-33-3]

    2 HMDB Compounds for RIPK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for RIPK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 55.8 12 15724446 (1), 15755681 (1), 16164210 (1), 16465024 (1) (see all 9)
    peptidoglycan 55 3 15289440 (1), 16582588 (1), 15691843 (1)
    serine 43.2 10 15755681 (1), 16164210 (1), 16465024 (1), 18606014 (1) (see all 8)
    sb 203580 40.8 4 15691843 (2), 15289440 (1), 15724446 (1)

    Search CenterWatch for drugs/clinical trials and news about RIPK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIPK2 gene: 
    NM_003821.5  

    Unigene Cluster for RIPK2:

    Receptor-interacting serine-threonine kinase 2
    Hs.103755  [show with all ESTs]
    Unigene Representative Sequence: NM_003821
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220751(uc003yee.3 uc003yef.3) ENST00000522965 ENST00000517696
    ENST00000518673 ENST00000540020

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPK2

    Additional mRNA sequence: 

    AF027706.1 AF064824.1 AF078530.1 AK075213.1 AK301448.1 AY358813.1 AY358814.1 AY524045.1 
    BC004553.2 

    3 DOTS entries:

    DT.313934  DT.95279922  DT.121469798 

    24/155 AceView cDNA sequences (see all 155):

    BM855477 BQ008463 BF754627 CB148463 BM973770 BM796243 BQ670832 AY358814 
    BQ773811 AY562996 AI380994 CR592019 AF078530 CF265050 AI745575 BM840808 
    BM469352 AA574167 AI475356 BC004553 CA413941 BG393551 CB851847 BM557041 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RIPK2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                    -                                                                           
    SP2:                    -     -     -                                                               
    SP3:                                                                                                


    ECgene alternative splicing isoforms for RIPK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIPK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGTGACTG
    RIPK2 Expression
    About this image


    See RIPK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIPK2

    SOURCE GeneReport for Unigene cluster: Hs.103755

    UniProtKB/Swiss-Prot: RIPK2_HUMAN, O43353
    Tissue specificity: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis,
    prostate, pancreas and lymph node

        SABiosciences Expression via Pathway-Focused PCR Arrays including RIPK2 (see all 10): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Apoptosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RIPK2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ripk21 , 5 receptor (TNFRSF)-interacting serine-threonine kinase more1, 5 85.16(n)1
    84.42(a)1
      4 (6.70 cM)5
    1926561  NM_138952.31  NP_620402.11 
     161227335 
    chicken
    (Gallus gallus)
    Aves RIPK21 receptor-interacting serine-threonine kinase 2 70.42(n)
    69.32(a)
      420215  NM_001030943.1  NP_001026114.1 
    lizard
    (Anolis carolinensis)
    Reptilia RIPK26
    --
    --
    63(a)
    21(a)
    1 ↔ 1
    possible ortholog
    4(21554203-21580215)
    LGc(6849338-6872565)
    zebrafish
    (Danio rerio)
    Actinopterygii ripk22 receptor-interacting serine-threonine kinase 2 74.62(n)   373874  AF487540.1 


    ENSEMBL Gene Tree for RIPK2 (if available)
    TreeFam Gene Tree for RIPK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIPK2 gene
    RIPK32  RIPK12  RIPK42  ANKK12  

    RIPK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/790 SNPs in RIPK2 are shown (see all 790)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1417372461,2
    --90768268(+) GGACAA/GTGAGT 1 -- us2k10--------
    rs69811121,2
    C,F,A--90768362(+) cctacC/Tcaaat 1 -- us2k18Minor allele frequency- T:0.13NA WA CSA 132
    rs4057341,2
    C,F,A,H--90768439(+) cccacG/Atgatt 1 -- us2k114Minor allele frequency- A:0.31NA WA CSA EA 377
    rs1865096081,2
    --90768460(+) TTGCTC/TACCCA 1 -- us2k10--------
    rs1901276741,2
    --90768498(+) GACGCC/GCGTTA 1 -- us2k10--------
    rs4267791,2
    C,F,A,H--90768566(+) CCGGGG/CGCGGT 1 -- us2k17Minor allele frequency- C:0.36NA WA CSA 14
    rs1827087811,2
    --90768599(+) ACTTTA/GGGAGG 1 -- us2k10--------
    rs583306171,2
    C--90768642(+) GAGACC/TAGCTT 1 -- us2k10--------
    rs1869871591,2
    --90768713(+) GGGCGA/CCTGTA 1 -- us2k10--------
    rs562759011,2
    C--90768747(+) GGCAGA/GAGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RIPK2 (90769975 - 90803292 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RIPK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv891180CNV Loss21882294
    nsv891181CNV Loss21882294
    nsv891182CNV Gain21882294


    Human Gene Mutation Database (HGMD): RIPK2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for RIPK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603455    OMIM disorders: --

    20/28 diseases for RIPK2 (see all 28):    About MalaCards
    taylor's syndrome    shigellosis    leprosy    peritonitis
    crohn's disease    pancreatitis    rhabdomyosarcoma    down syndrome
    non-hodgkin lymphoma    inflammatory bowel disease    hodgkin's lymphoma    huntington's disease
    periodontitis    chronic lymphocytic leukemia    tuberculosis    multiple sclerosis
    ischemia    asthma    rheumatoid arthritis    arthritis

    2 diseases from the University of Copenhagen DISEASES database for RIPK2:
    Taylor's syndrome     Crohn's disease

    RIPK2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for RIPK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 37.3 3 18205922 (1), 16354923 (1), 18702009 (1)
    necrosis 24.2 6 17348859 (1), 10559258 (1), 10880512 (1), 11551959 (1) (see all 5)
    tumors 0 4 10559258 (1), 10880512 (1), 11551959 (1), 10329646 (1)

    Genetic Association Database (GAD): RIPK2
    Human Genome Epidemiology (HuGE) Navigator: RIPK2 (8 documents)

    Export disorders for RIPK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIPK2 gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with RIPK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. (PubMed id 9575181)1, 2, 3, 9 Inohara N.... Nunez G. (1998)
    2. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. (PubMed id 9705938)1, 2, 3, 9 Thome M.... Tschopp J. (1998)
    3. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. (PubMed id 18079694)1, 2, 9 Hasegawa M....Inohara N. (2008)
    4. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. (PubMed id 9642260)1, 2, 9 McCarthy J.V.... Dixit V.M. (1998)
    5. ITCH K63-ubiquitinates the NOD2 binding protein, RIP2 , to influence inflammatory signaling pathways. (PubMed id 19592251)1, 2, 9 Tao M....Abbott D.W. (2009)
    6. Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. (PubMed id 17054981)1, 2, 9 Manon F....Cusack S. (2007)
    7. cIAP1/2 are direct E3 ligases conjugating diverse typ es of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) . (PubMed id 21931591)1, 2 Bertrand M.J....Vandenabeele P. (2011)
    8. Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (2010)
    9. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    10. Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses. (PubMed id 21123652)1, 2 Tigno-Aranjuez J.T....Abbott D.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8767 HGNC: 10020 AceView: RIPK2 Ensembl:ENSG00000104312 euGenes: HUgn8767
    ECgene: RIPK2 Kegg: 8767 H-InvDB: RIPK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIPK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RIPK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIPK2 gene:
    Search GeneIP for patents involving RIPK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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