RIPK1 Gene
protein-coding GIFtS: 66
GCID: GC06P003064
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|
receptor (TNFRSF)-interacting serine-threonine kinase 1
| |
Aliases
for RIPK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 11 2 | | RIP-12 3 | | RIP1 2 3 | | RIP12 3 | | Cell Death Protein RIP2 3 | | Receptor Interacting Protein2 | | Receptor-Interacting Protein 12 3 | | Receptor-Interacting Serine/Threonine-Protein Kinase 12 | | Serine/Threonine-Protein Kinase RIP2 3 | | EC 2.7.11.13 |
Export aliases for RIPK1 gene to outside databasesPrevious GC identifers: GC06P003062 GC06P003022 GC06P002949 |
Summaries
for RIPK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546Function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) followingdeath receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation ofTNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in themitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events includingthe activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatorysubunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellularRHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms anecrosis-inducing complex
Gene Wiki entry for RIPK1
|
Genomic Views
for RIPK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RIPK1 gene promoter:
GR p53 Pax-6 CUTL1 Arnt Evi-1 N-Myc GR-alpha NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RIPK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p25.2 Ensembl cytogenetic band: 6p25.2 HGNC cytogenetic band: 6p25.2RIPK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P003064: view genomic region
(about GC identifiers)
Start:
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3,064,092 bp from pter |
End:
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3,115,421 bp from pter |
Size:
|
51,330 bases |
Orientation:
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plus strand |
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Proteins
for RIPK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546 (See
protein sequence)Recommended Name: Receptor-interacting serine/threonine-protein kinase 1 Size: 671 amino acids; 75931 Da
Subunit: Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif). UponTNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leadsto PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts (via the death domain) with TNFRSF6(via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process.Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alphastimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1 (By similarity). Interacts withBIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK3 and MLKL
Subcellular location: Cytoplasm. Cell membrane (By similarity)
Sequence caution: Sequence=BAG65471.1; Type=Erroneous initiation;
Secondary accessions: A0AV89 B2RAG1 B4E3F9 Q13180 Q59H33Alternative splicing: 2 isoforms: Q13546-1 Q13546-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RIPK1: NX_Q13546
Post-translational modifications:
Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation andenhances pro-apoptotic signaling through the TRADD-FADD interaction1
RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-161 by RIPK3 is necessaryfor the formation of the necroptosis-inducing complex1
Ubiquitinated by 'Lys-11'-, 'Lys-48'-, 'Lys-63'- and linear-linked type ubiquitin. Polyubiquitination with'Lys-63'-linked chains by TRAF2 induces association with the IKK complex. Deubiquitination of 'Lys-63'-linked chainsand polyubiquitination with 'Lys-48'-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and consequentlydown-regulates TNF-alpha-induced NFkappa-B signaling. Linear polyubiquitinated; the head-to-tail polyubiquitination ismediated by the LUBAC complex. LPS-mediated activation of NF-kappa-B. Also ubiquitinated with 'Lys-11'-linked chains.Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation ofNF-kappa-B1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13546
RIPK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003795.2
ENSEMBL proteins: ENSP00000259808 ENSP00000442294 ENSP00000369773 Reactome Protein details: Q13546
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
RIPK1 for ontologies About GeneDecksing
RIPK1 Antibody Products:
Assay Products for RIPK1: |
Protein
Domains /
Families
for RIPK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RIPK1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q13546ProtoNet protein and cluster: Q13546 1 Blocks protein family: IPB000488 Death domain
UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546Domain: Contains a C-terminal death domain (DD) that engages other DD-containing proteins as well as a central(intermediate) region important for NF-kB activation and RHIM-dependent signalingSimilarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase familySimilarity: Contains 1 death domainSimilarity: Contains 1 protein kinase domain |
Function
for RIPK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546Function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) followingdeath receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation ofTNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in themitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events includingthe activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatorysubunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellularRHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms anecrosis-inducing complexCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Inhibited by necrostatin-1 Genatlas biochemistry entry for RIPK1:receptor interacting serine-threonine kinase 1,expressed in brain,small intestine,testis,interacting weakly withTNFRSF1A,associating with the intracellular domain of TNFRSF6 (CD95,FAS)
Enzyme Number (IUBMB): EC 2.7.11.11
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RIPK1 (NM_003804) | |  | Sino Biological Human cDNA Clone for RIPK1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIPK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
RIPK1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for RIPK1:
Animal Models:
Mouse knock-out Ripk1tm1Led for RIPK1
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ripk1):
RIPK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RIPK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/37 super-pathways (see all 37) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TWEAK Pathway | | | 2 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 3 | Apoptosis and survival_Caspase cascade | | | 4 | Death Receptor Signalling | | | 5 | RIP-mediated NFkB activation via DAI | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 EMD Millipore Pathways for RIPK1 (see all 10)
2  R&D Systems Pathways for RIPK1
5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RIPK1 (see all 17)
2 
Cell Signaling Technology (CST) Pathways for RIPK1
5/10  GeneGo (Thomson Reuters) Pathways for RIPK1 (see all 10)
5/14  BioSystems Pathways for RIPK1 (see all 14)
5/21 
Reactome Pathways for RIPK1 (see all 21)
5 
Kegg Pathways (Kegg details for RIPK1):
RIPK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIPK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/130 Interacting proteins for RIPK1 (Q135461, 2, 3 ENSP000002598084) via UniProtKB, MINT, STRING, and/or I2D (see all 130)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TRIM38 | O006352, 3, ENSP000002300994 | MINT-18397 MINT-18398 I2D:
score=3 STRING: ENSP00000230099 | | CASP8 | Q147901, 3, ENSP000003512734 | EBI-358507,EBI-78060 I2D:
score=5 STRING: ENSP00000351273 | | TRADD | Q156282, 3, ENSP000003412684 | MINT-17369 I2D:
score=5 STRING: ENSP00000341268 | | RIPK3 | Q9Y5721, 3, ENSP000002162744 | EBI-358507,EBI-358587 I2D:
score=4 STRING: ENSP00000216274 | | BIRC3 | Q134891, 3, ENSP000002634644 | EBI-358507,EBI-517709 I2D:
score=2 STRING: ENSP00000263464 |
About this table
Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
TAS | -- | | GO:0006915 | apoptotic process |
TAS | -- | | GO:0006917 | induction of apoptosis |
IMP | 8612133 | | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
TAS | -- | | GO:0007165 | signal transduction |
TAS | 8612133 |
RIPK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RIPK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RIPK1 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for RIPK1 |
 Browse Tocris compounds for RIPK1
2 HMDB Compounds for RIPK1 About this table
10/15 Novoseek chemical compound relationships for RIPK1 gene (see all 15) About this table
Search CenterWatch for drugs/clinical trials and news about RIPK1
|
Transcripts
for RIPK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RIPK1 gene: NM_003804.3 Unigene Cluster for RIPK1: Receptor (TNFRSF)-interacting serine-threonine kinase 1 Hs.519842 [show with all ESTs]Unigene Representative Sequence: AB2089265 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000490396 ENST00000479389 ENST00000259808(uc003muv.4 uc010jni.3 uc003mux.3 uc011dhs.2)
ENST00000541791 ENST00000380409
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RIPK1 (NM_003804) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIPK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK1 |
Additional cDNA sequence: AB208926.1 AJ420482.1 AK096523.1 AK304701.1 AK314176.1 BC126254.1 BC126256.1 U25994.1 U50062.1 16 DOTS entries: DT.100784005 DT.121404150 DT.87016751 DT.92001506 DT.101961566 DT.121404152 DT.91852686 DT.40252326 DT.70103908 DT.75144380 DT.92003526 DT.100697993 DT.95201652 DT.99984545 DT.91915627 DT.95128638 24/150 AceView cDNA sequences (see all 150): CB159581 Z39725 AL039269 AI971246 AI418080 BM722050 Z45688 AI611751 CA748651 AI520889 AW236421 BM853507 AI420474 Z43667 CR618624 AI754860 AI801478 AA294820 AI174323 BX436346 AL521376 BM722088 AI312797 AI538489
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RIPK1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RIPK1
|
Expression
for RIPK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RIPK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTTCAGC
About this image
See RIPK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIPK1
SOURCE GeneReport for Unigene cluster: Hs.519842
SABiosciences Expression via Pathway-Focused PCR Arrays including RIPK1 (see all 8):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIPK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIPK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK1 |
Orthologs
for RIPK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RIPK1 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for RIPK1 (if available)
TreeFam Gene Tree for RIPK1 (if available) |
Paralogs
for RIPK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RIPK1 gene
- RIPK32 RIPK42 RIPK22 ANKK12
RIPK1 for paralogs About GeneDecksing
|
Genomic Variants
for RIPK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RIPK1 (3064092 - 3115421 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RIPK1
1 CNV: 69299
2 Indels: 28263 69298 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIPK1 |
|
Disorders
/ Diseases
for RIPK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RIPK1 for disorders About GeneDecksing
OMIM gene information: 603453
OMIM disorders: --
20/33  diseases for RIPK1 (see all 33): About MalaCardsdiffuse large b-cell lymphoma non-small cell lung carcinoma lichen planus b-cell lymphomas
oral lichen planus non-hodgkin lymphoma burkitt's lymphoma oral squamous cell carcinoma
systemic lupus erythematosus squamous cell carcinoma lupus erythematosus hodgkin's lymphoma
chronic lymphocytic leukemia lymphocytic leukemia myelodysplastic syndrome rheumatoid arthritis
protein s deficiency colon cancer hepatitis c lung carcinoma
9 Novoseek disease relationships for RIPK1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: RIPK1 (15 documents)
Export disorders for RIPK1 gene to outside databases
|
Publications
for RIPK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RIPK1 gene, integrated from 9 sources (see all 330):
(articles sorted by number of sources associating them with RIPK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PubMed id 8612133)1, 2, 3, 9 Hsu H.... Goeddel D.V. (1996)
- RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. (PubMed id 7538908)1, 2, 3 Stanger B.Z.... Seed B. (1995)
- Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PubMed id 11734559)1, 2, 9 Sun X....Dixit V.M. (2002)
- The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. (PubMed id 10409763)1, 2, 9 Izumi K.M....Kieff E.D. (1999)
- RIP3, a novel apoptosis-inducing kinase. (PubMed id 10358032)1, 2, 9 Sun X.... Dixit V.M. (1999)
- The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome. (PubMed id 11116146)1, 2, 9 Habib A.A....Vartanian T. (2001)
- The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. (PubMed id 10356400)1, 2, 9 Sanz L.... Moscat J. (1999)
- Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. (PubMed id 11101870)1, 2, 9 Holler N....Tschopp J. (2000)
- Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. (PubMed id 9927690)1, 2, 9 Li Y.... Horwitz M.S. (1999)
- RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PubMed id 17449468)1, 2, 9 Tian Y....Shu H.B. (2007)
|
External Searches for RIPK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RIPK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RIPK1 gene
(According to HUGE)
About This Section
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Specialized Databases showing RIPK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RIPK1 gene:
Search GeneIP for patents involving RIPK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RIPK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for RIPK1 | | OriGene shRNA RFP for RIPK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIPK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIPK1 | | | OriGene Protein Over-expression Lysate for RIPK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RIPK1 | | OriGene 3'-UTR Clone for RIPK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIPK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RIPK1 | | OriGene Custom Protein Services for RIPK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RIPK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIPK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIPK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIPK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIPK1 |
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| | Antibodies & Assays for RIPK1 |
| | | | Search Tocris compounds for RIPK1 |
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 | | | RIPK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK1 |
|  |  |  | | | | ThermoFisher Antibody for RIPK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK1 |
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