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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIPK1 Gene

protein-coding   GIFtS: 68
GCID: GC06P003064

Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 11 2     RIP-12 3
Cell Death Protein RIP2 3     RIP12 3
Receptor-Interacting Protein 12 3     Receptor Interacting Protein2
Serine/Threonine-Protein Kinase RIP2 3     Receptor-Interacting Serine/Threonine-Protein Kinase 12
RIP2 3     EC 2.7.11.13

External Ids:    HGNC: 100191   Entrez Gene: 87372   Ensembl: ENSG000001372757   OMIM: 6034535   UniProtKB: Q135463   

Export aliases for RIPK1 gene to outside databases

Previous GC identifers: GC06P003062 GC06P003022 GC06P002949


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RIPK1 Gene: 
RIPK1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) is a protein-coding gene. Diseases associated with RIPK1 include oral lichen planus, and lichen planus, and among its related super-pathways are DR3 Signaling and Apoptosis and survival Caspase cascade. GO annotations related to this gene include protein kinase activity and identical protein binding. An important paralog of this gene is RIPK3.

UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546
Function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis)
following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon
activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor.
Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK
apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication
with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway,
which in turn mediate downstream events including the activation of genes encoding inflammatory molecules.
Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for
NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and
cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex

Gene Wiki entry for RIPK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIPK1 gene promoter:
         GR   p53   Pax-6   CUTL1   Arnt   Evi-1   N-Myc   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RIPK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIPK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

RIPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIPK1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P003064:  view genomic region     (about GC identifiers)

Start:
3,064,225 bp from pter      End:
3,115,421 bp from pter
Size:
51,197 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546 (See protein sequence)
Recommended Name: Receptor-interacting serine/threonine-protein kinase 1  
Size: 671 amino acids; 75931 Da
Subunit: Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif). Upon
TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex
leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts (via the death domain) with
TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a
TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with
SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1 (By
similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Upon TNF-induced necrosis, forms in
complex with PGAM5, RIPK3 and MLKL. Interacts (via kinase domain) with DAB2IP (via Ras-GAP domain); the
interaction occurs in a TNF-alpha-dependent manner
Subcellular location: Cytoplasm. Cell membrane (By similarity)
Sequence caution: Sequence=BAG65471.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for RIPK1:
4ITH (3D)        4ITI (3D)        4ITJ (3D)    
Secondary accessions: A0AV89 B2RAG1 B4E3F9 Q13180 Q59H33
Alternative splicing: 2 isoforms:  Q13546-1   Q13546-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIPK1: NX_Q13546

Explore proteomics data for RIPK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and
    enhances pro-apoptotic signaling through the TRADD-FADD interaction
  • UniProtKB: RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-161 by RIPK3 is
    necessary for the formation of the necroptosis-inducing complex
  • UniProtKB: Ubiquitinated by 'Lys-11'-, 'Lys-48'-, 'Lys-63'- and linear-linked type ubiquitin. Polyubiquitination with
    'Lys-63'-linked chains by TRAF2 induces association with the IKK complex. Deubiquitination of 'Lys-63'-linked
    chains and polyubiquitination with 'Lys-48'-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and
    consequently down-regulates TNF-alpha-induced NFkappa-B signaling. Linear polyubiquitinated; the head-to-tail
    polyubiquitination is mediated by the LUBAC complex. LPS-mediated activation of NF-kappa-B. Also ubiquitinated
    with 'Lys-11'-linked chains. Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and
    BIRC3/c-IAP2, leading to activation of NF-kappa-B
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13546

  • RIPK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIPK1 Protein Expression
    REFSEQ proteins: NP_003795.2  
    ENSEMBL proteins: 
     ENSP00000259808   ENSP00000442294   ENSP00000369773  
    Reactome Protein details: Q13546
    Human Recombinant Protein Products for RIPK1: 
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    OriGene Protein Over-expression Lysate for RIPK1
    OriGene Custom MassSpec 
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    Novus Biologicals RIPK1 Proteins
    Novus Biologicals RIPK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIPK1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA16507998
    GO:0005829cytosol TAS--
    GO:0031264death-inducing signaling complex IDA11101870
    GO:0043234protein complex ----

    RIPK1 for ontologies           About GeneDecksing



    RIPK1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RIPK1
    R&D Systems Antibodies for RIPK1 (RIP1)
    Cell Signaling Technology (CST) Antibodies for RIPK1 
    OriGene Antibodies for RIPK1
    OriGene Custom Antibody Services for RIPK1
    GenScript Custom Superior Antibodies Services for RIPK1
    Novus Biologicals RIPK1 Antibodies
    Abcam antibodies for RIPK1
    Cloud-Clone Corp. Antibodies for RIPK1 
    ThermoFisher Antibodies for RIPK1
    LSBio Antibodies in human, mouse, rat for RIPK1 

    Assay Products for RIPK1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RIPK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RIPK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RIPK1 
    Cloud-Clone Corp. CLIAs for RIPK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: receptor (TNFRSF)-interacting serine-threonine kinase 1 
    Receptor interacting protein kinase (RIPK) family

    5/7 InterPro protein domains (see all 7):
     IPR011029 DEATH-like_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR025735 RHIM_dom

    Graphical View of Domain Structure for InterPro Entry Q13546

    ProtoNet protein and cluster: Q13546

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546
    Domain: Contains a C-terminal death domain (DD) that engages other DD-containing proteins as well as a central
    (intermediate) region important for NF-kB activation and RHIM-dependent signaling
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 protein kinase domain


    RIPK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIPK1_HUMAN, Q13546
    Function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis)
    following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon
    activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor.
    Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK
    apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication
    with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway,
    which in turn mediate downstream events including the activation of genes encoding inflammatory molecules.
    Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for
    NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and
    cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by necrostatins, including necrostatin-1, necrostatin-3 and necrostatin-4

         Genatlas biochemistry entry for RIPK1:
    receptor interacting serine-threonine kinase 1,expressed in brain,small intestine,testis,interacting weakly with
    TNFRSF1A,associating with the intracellular domain of TNFRSF6 (CD95,FAS)

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15001576
    GO:0004674protein serine/threonine kinase activity IDA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005123death receptor binding IPI7538908
    GO:0005515protein binding IPI10356400
         
    RIPK1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RIPK1:
     Decreased Salmonella enterica   Decreased substrate adherent c  Increased cell number in G2M,   Increased mitotic index 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ripk1):
     adipose tissue  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging 

    RIPK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ripk1tm1Led for RIPK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIPK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIPK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIPK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIPK1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIPK1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate RIPK1:
    hsa-miR-942 hsa-miR-1323 hsa-miR-548o hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidRIPK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RIPK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIPK1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of RIPK1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RIPK1 (see all 8)
    OriGene ORF clones in mouse, rat for RIPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIPK1 (NM_003804)
    Sino Biological Human cDNA Clone for RIPK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK1
    Sirion Biotech Customized lentivirus for stable overexpression of RIPK1 
                         Customized lentivirus expression plasmids for stable overexpression of RIPK1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RIPK1 About   (see all 42)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    Apoptosis Modulation by HSP700.35
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival Caspase cascade0.44
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    4Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    5RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    RIG-I-like receptor signaling pathway0.52

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for RIPK1 (see all 10)
        Development Angiopoietin - Tie2 signaling
    Cytoskeleton remodeling FAK signaling
    Apoptosis and survival FAS signaling cascades
    Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway

    2 R&D Systems Pathways for RIPK1
        Toll-Like receptor Signaling Pathways
    Apoptosis Signaling Pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RIPK1 (see all 17)
        MAPK Signaling
    TWEAK Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for RIPK1
        Apoptosis and Autophagy
    NF-kappaB Signaling

    5/10 GeneGo (Thomson Reuters) Pathways for RIPK1 (see all 10)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    5/14 BioSystems Pathways for RIPK1 (see all 14)
        Apoptosis
    EGFR1 Signaling Pathway
    p38 MAPK Signaling Pathway
    Toll-like receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway

    3 Sino Biological Pathways for RIPK1 
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    5/22        Reactome Pathways for RIPK1 (see all 22)
        NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    IKK complex recruitment mediated by RIP1
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Toll-Like Receptors Cascades
    Apoptosis


    5/8         Kegg Pathways  (Kegg details for RIPK1) (see all 8):
        NF-kappa B signaling pathway
    Apoptosis
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway


    RIPK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIPK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/149 Interacting proteins for RIPK1 (Q135461, 2, 3 ENSP000002598084) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-49051 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49051 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49051 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49051 I2D: score=2 
    ENSG00000232421P074372, 3MINT-49051 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/43 biological process terms (GO ID links to tree view) (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IMP17389591
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process TAS--

    RIPK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RIPK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for RIPK1

    Browse Tocris compounds for RIPK1

    2 HMDB Compounds for RIPK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/15 Novoseek inferred chemical compound relationships for RIPK1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-2 64 3 15327770 (1), 17449468 (1)
    geldanamycin 57.1 11 10744744 (2), 16289096 (1), 17951993 (1)
    cycloheximide 16.5 3 10919673 (2)
    threonine 16.4 3 11369754 (1), 15178406 (1)
    adriamycin 15.1 2 19967054 (1)
    serine 5.08 3 11369754 (1), 15178406 (1)
    actinomycin d 2.71 3 10919673 (2)
    estrogen 1.49 3 9115274 (1), 10731120 (1)
    phosphatidylinositol 0.0487 3 15115707 (2), 15128824 (1)
    atp 0 2 18566385 (2)

    Search CenterWatch for drugs/clinical trials and news about RIPK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIPK1 gene: 
    NM_003804.3  

    Unigene Cluster for RIPK1:

    Receptor (TNFRSF)-interacting serine-threonine kinase 1
    Hs.519842  [show with all ESTs]
    Unigene Representative Sequence: AB208926
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479389 ENST00000259808(uc003muv.4 uc010jni.3 uc003mux.3 uc011dhs.2)
    ENST00000541791 ENST00000380409
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector: RIPK1 (NM_003804)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK1
    Sirion Biotech Customized lentivirus for stable overexpression of RIPK1 
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    Primer
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    Additional mRNA sequence: 

    AB208926.1 AJ420482.1 AK096523.1 AK304701.1 AK314176.1 BC126254.1 BC126256.1 U25994.1 
    U50062.1 

    16 DOTS entries:

    DT.100784005  DT.121404150  DT.87016751  DT.92001506  DT.101961566  DT.121404152  DT.91852686  DT.40252326 
    DT.70103908  DT.75144380  DT.92003526  DT.100697993  DT.95201652  DT.99984545  DT.91915627  DT.95128638 

    24/150 AceView cDNA sequences (see all 150):

    CR618624 AI611751 AL039269 AI420474 AI971246 CB159581 AW236421 AI801478 
    Z39725 AI418080 AI754860 BM853507 CA425127 BM722050 AK096523 BF436924 
    BM722088 Z43667 AL521376 AI174323 BX436346 AA294820 AI312797 AI380341 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RIPK1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                      -                                                   
    SP2:                          -           -                                                   
    SP3:                                                                                          
    SP4:                                                                                          


    ECgene alternative splicing isoforms for RIPK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTTCAGC
    RIPK1 Expression
    About this image


    See RIPK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIPK1

    SOURCE GeneReport for Unigene cluster: Hs.519842
        SABiosciences Expression via Pathway-Focused PCR Arrays including RIPK1 (see all 8): 
              Antiviral Response in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Antibacterial Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RIPK1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ripk11 , 5 receptor (TNFRSF)-interacting serine-threonine kinase more1, 5 79.08(n)1
    71.6(a)1
      13 (14.01 cM)5
    197661  NM_009068.31  NP_033094.31 
     340023635 
    chicken
    (Gallus gallus)
    Aves RIPK11 receptor (TNFRSF)-interacting serine-threonine kinase more 59.47(n)
    51(a)
      378921  NM_204402.1  NP_989733.1 
    lizard
    (Anolis carolinensis)
    Reptilia RIPK16
    receptor (TNFRSF)-interacting serine-threonine kin...
    48(a)
    1 ↔ 1
    GL343247.1(964569-998113)
    zebrafish
    (Danio rerio)
    Actinopterygii ripk1l1 receptor (TNFRSF)-interacting serine-threonine kinase more 51.92(n)
    42.81(a)
      567460  NM_001043350.1  NP_001036815.1 


    ENSEMBL Gene Tree for RIPK1 (if available)
    TreeFam Gene Tree for RIPK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIPK1 gene
    RIPK32  RIPK42  RIPK22  ANKK12  

    RIPK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1111 SNPs in RIPK1 are shown (see all 1111)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410404
    A colorectal adenocarcinoma sample4--see VAR_0410402 V I mis40--------
    VAR_0410414
    A colorectal adenocarcinoma sample4--see VAR_0410412 A V mis40--------
    VAR_0410394
    A colorectal adenocarcinoma sample4--see VAR_0410392 A V mis40--------
    rs1918456841,2
    --3075214(+) CAGCCA/GGGATG 1 -- us2k10--------
    rs1503703201,2
    --3075247(+) CATCCA/GTAGCC 1 -- us2k10--------
    rs1379421411,2
    --3075266(+) ACTCTC/TAAAGC 1 -- us2k10--------
    rs1494547801,2
    --3075284(+) AGACAC/TGCACA 1 -- us2k10--------
    rs1828647911,2
    --3075285(+) GACACA/GCACAT 1 -- us2k10--------
    rs23261731,2
    C,F,O,A,H--3075553(+) GGGGAG/AAATGA 1 -- us2k134Minor allele frequency- A:0.50NS EA NA WA CSA 3516
    rs175132701,2
    C,F--3075554(+) GGGAGA/TATGAA 1 -- us2k12Minor allele frequency- T:0.02NS 94

    HapMap Linkage Disequilibrium report for RIPK1 (3064225 - 3115421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RIPK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1036383CNV Deletion17803354
    esv23861CNV Loss19812545
    nsv883404CNV Loss21882294
    esv25797CNV Gain19812545
    nsv883403CNV Gain+Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603453    OMIM disorders: --

    20/35 diseases for RIPK1 (see all 35):    About MalaCards
    oral lichen planus    lichen planus    malt lymphoma    burkitt's lymphoma
    protein s deficiency    non-small cell lung carcinoma    diffuse large b-cell lymphoma    b-cell lymphomas
    glomerulonephritis    myelodysplastic syndromes    oral squamous cell carcinoma    non-hodgkin lymphoma
    hodgkin's lymphoma    colon cancer    acute leukemia    chronic lymphocytic leukemia
    ischemia    hepatitis c    systemic lupus erythematosus    squamous cell carcinoma


    RIPK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for RIPK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 72.4 43 18566385 (3), 10744744 (2), 15572679 (2), 11369754 (2) (see all 25)
    tumors 54.4 38 15121855 (2), 10744744 (2), 11369754 (2), 15572679 (2) (see all 23)
    colon cancer 23.7 1 16825191 (1)
    inflammation 18.2 1 17222914 (1)
    burkitt lymphoma 11.5 1 10409763 (1)
    leukemia 0 2 9375749 (1)
    shock 0 2 17222914 (1), 16424045 (1)
    breast cancer 0 1 16459337 (1)
    lymphoma 0 2 9375749 (1)

    Genetic Association Database (GAD): RIPK1
    Human Genome Epidemiology (HuGE) Navigator: RIPK1 (15 documents)

    Export disorders for RIPK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIPK1 gene, integrated from 9 sources (see all 347):
    (articles sorted by number of sources associating them with RIPK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PubMed id 8612133)1, 2, 3, 9 Hsu H.... Goeddel D.V. (1996)
    2. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. (PubMed id 7538908)1, 2, 3 Stanger B.Z.... Seed B. (1995)
    3. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PubMed id 11734559)1, 2, 9 Sun X....Dixit V.M. (2002)
    4. The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. (PubMed id 10409763)1, 2, 9 Izumi K.M....Kieff E.D. (1999)
    5. RIP3, a novel apoptosis-inducing kinase. (PubMed id 10358032)1, 2, 9 Sun X.... Dixit V.M. (1999)
    6. The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome. (PubMed id 11116146)1, 2, 9 Habib A.A....Vartanian T. (2001)
    7. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. (PubMed id 10356400)1, 2, 9 Sanz L.... Moscat J. (1999)
    8. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. (PubMed id 11101870)1, 2, 9 Holler N....Tschopp J. (2000)
    9. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PubMed id 18990758)1, 4, 9 Cerhan J.R....Slager S.L. (2008)
    10. Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. (PubMed id 9927690)1, 2, 9 Li Y.... Horwitz M.S. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8737 HGNC: 10019 AceView: RIPK1 Ensembl:ENSG00000137275 euGenes: HUgn8737
    ECgene: RIPK1 Kegg: 8737 H-InvDB: RIPK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIPK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RIPK1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ripk1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIPK1 gene:
    Search GeneIP for patents involving RIPK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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