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RIPK1 Gene

protein-coding   GIFtS: 69
GCID: GC06P003064

Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 11 2     RIP-12 3
Cell Death Protein RIP2 3     RIP12 3
Receptor-Interacting Protein 12 3     Receptor Interacting Protein2
Serine/Threonine-Protein Kinase RIP2 3     Receptor-Interacting Serine/Threonine-Protein Kinase 12
RIP2 3     EC 2.7.11.13

External Ids:    HGNC: 100191   Entrez Gene: 87372   Ensembl: ENSG000001372757   OMIM: 6034535   UniProtKB: Q135463   

Export aliases for RIPK1 gene to outside databases

Previous GC identifers: GC06P003062 GC06P003022 GC06P002949


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RIPK1 Gene:
RIPK1 (receptor (TNFRSF)-interacting serine-threonine kinase 1) is a protein-coding gene. Diseases associated with RIPK1 include oral lichen planus, and malt lymphoma. GO annotations related to this gene include protein kinase activity and identical protein binding. An important paralog of this gene is RIPK3.

UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546
Function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis)
following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon
activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor.
Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK
apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication
with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway,
which in turn mediate downstream events including the activation of genes encoding inflammatory molecules.
Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for
NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and
cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex

Gene Wiki entry for RIPK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RIPK1 gene promoter:
         GR   p53   Pax-6   CUTL1   Arnt   Evi-1   N-Myc   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RIPK1 promoter sequence
   Search Chromatin IP Primers for RIPK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.2   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

RIPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIPK1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P003064:  view genomic region     (about GC identifiers)

Start:
3,064,225 bp from pter      End:
3,115,421 bp from pter
Size:
51,197 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546 (See protein sequence)
Recommended Name: Receptor-interacting serine/threonine-protein kinase 1  
Size: 671 amino acids; 75931 Da
Subunit: Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif). Upon
TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex
leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts (via the death domain) with
TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a
TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with
SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1 (By
similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Upon TNF-induced necrosis, forms in
complex with PGAM5, RIPK3 and MLKL. Interacts (via kinase domain) with DAB2IP (via Ras-GAP domain); the
interaction occurs in a TNF-alpha-dependent manner. Interacts with ARHGEF2. Interacts (via protein kinase domain)
with RFFL; involved in RIPK1 ubiquitination
Sequence caution: Sequence=BAG65471.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for RIPK1:
4ITH (3D)        4ITI (3D)        4ITJ (3D)        4NEU (3D)    
Secondary accessions: A0AV89 B2RAG1 B4E3F9 Q13180 Q59H33
Alternative splicing: 2 isoforms:  Q13546-1   Q13546-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIPK1: NX_Q13546

Explore proteomics data for RIPK1 at MOPED

Post-translational modifications: 

  • Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and
    enhances pro-apoptotic signaling through the TRADD-FADD interaction1
  • RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-161 by RIPK3 is
    necessary for the formation of the necroptosis-inducing complex1
  • Ubiquitinated by 'Lys-11'-, 'Lys-48'-, 'Lys-63'- and linear-linked type ubiquitin. Polyubiquitination with
    'Lys-63'-linked chains by TRAF2 induces association with the IKK complex. Deubiquitination of 'Lys-63'-linked
    chains and polyubiquitination with 'Lys-48'-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and
    consequently down-regulates TNF-alpha-induced NFkappa-B signaling. 'Lys-48'-linked polyubiquitination by RFFL
    also promotes proteasomal degradation and negatively regulates TNF-alpha-induced NFkappa-B signaling. Linear
    polyubiquitinated; the head-to-tail polyubiquitination is mediated by the LUBAC complex. LPS-mediated activation
    of NF-kappa-B. Also ubiquitinated with 'Lys-11'-linked chains. Polyubiquitinated with 'Lys-48' and
    'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B1
  • Ubiquitination2 at Lys377
  • Modification sites at PhosphoSitePlus

  • See RIPK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003795.2  
    ENSEMBL proteins: 
     ENSP00000259808   ENSP00000442294   ENSP00000369773  
    Reactome Protein details: Q13546

    RIPK1 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
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    Novus Biologicals RIPK1 Proteins
    Novus Biologicals RIPK1 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIPK1

    RIPK1 Antibody Products:

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    Cell Signaling Technology (CST) Antibodies for RIPK1 
    OriGene Antibodies for RIPK1
    OriGene Custom Antibody Services for RIPK1
    Novus Biologicals RIPK1 Antibodies
    Abcam antibodies for RIPK1
    Cloud-Clone Corp. Antibodies for RIPK1
    ThermoFisher Antibodies for RIPK1
    LSBio Antibodies in human, mouse, rat for RIPK1

    RIPK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RIPK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RIPK1
    Cloud-Clone Corp. CLIAs for RIPK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: receptor (TNFRSF)-interacting serine-threonine kinase 1
    Receptor interacting protein kinase (RIPK) family

    Selected InterPro protein domains (see all 7):
     IPR011029 DEATH-like_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR025735 RHIM_dom

    Graphical View of Domain Structure for InterPro Entry Q13546

    ProtoNet protein and cluster: Q13546

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: RIPK1_HUMAN, Q13546
    Domain: Contains a C-terminal death domain (DD) that engages other DD-containing proteins as well as a central
    (intermediate) region important for NF-kB activation and RHIM-dependent signaling
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 death domain
    Similarity: Contains 1 protein kinase domain


    RIPK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIPK1_HUMAN, Q13546
    Function: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis)
    following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon
    activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor.
    Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK
    apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication
    with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway,
    which in turn mediate downstream events including the activation of genes encoding inflammatory molecules.
    Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for
    NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and
    cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by necrostatins, including necrostatin-1, necrostatin-3 and necrostatin-4

         Genatlas biochemistry entry for RIPK1:
    receptor interacting serine-threonine kinase 1,expressed in brain,small intestine,testis,interacting weakly with
    TNFRSF1A,associating with the intracellular domain of TNFRSF6 (CD95,FAS)

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IMP--
    GO:0004674protein serine/threonine kinase activity IDA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005123death receptor binding IPI7538908
    GO:0005515protein binding IPI10356400
         
    RIPK1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RIPK1:
     Decreased Salmonella enterica   Decreased substrate adherent c  Increased cell number in G2M,   Increased mitotic index 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ripk1):
     adipose tissue  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging 

    RIPK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ripk1tm1Led for RIPK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RIPK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RIPK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIPK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIPK1

    miRNA
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    Block miRNA regulation of human, mouse, rat RIPK1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate RIPK1:
    hsa-miR-942 hsa-miR-1323 hsa-miR-548o hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidRIPK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RIPK1
    Predesigned siRNA for gene silencing in human, mouse, rat RIPK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RIPK1

    Clone
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    OriGene clones in human, mouse for RIPK1 (see all 8)
    OriGene ORF clones in mouse, rat for RIPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIPK1 (NM_003804)
    Sino Biological Human cDNA Clone for RIPK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIPK1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RIPK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RIPK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RIPK1_HUMAN, Q13546: Cytoplasm. Cell membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion4
    plasma membrane4
    nucleus2
    cytoskeleton1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA16507998
    GO:0005829cytosol TAS--
    GO:0031264death-inducing signaling complex IDA11101870
    GO:0043234protein complex ----

    RIPK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RIPK1 About   (see all 38)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1TWEAK Pathway
    TWEAK Pathway0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    Apoptosis Modulation by HSP700.35
    2Cytosolic sensors of pathogen-associated DNA
    RIP-mediated NFkB activation via ZBP10.81
    Cytosolic sensors of pathogen-associated DNA0.38
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Cytosolic DNA-sensing pathway0.33
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -100.00
    RIG-I-like receptor signaling pathway0.47
    5Apoptosis and survival Caspase cascade
    Apoptosis and survival Caspase cascade0.44
    Caspase cascade in apoptosis0.42
    Apoptosis and survival FAS signaling cascades0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for RIPK1
        Toll-Like receptor Signaling Pathways
    Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RIPK1 (see all 17)
        MAPK Signaling
    TWEAK Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for RIPK1
        Apoptosis and Autophagy
    NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for RIPK1 (see all 10)
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades
    Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

    Selected BioSystems Pathways for RIPK1 (see all 15)
        Apoptosis
    EGFR1 Signaling Pathway
    p38 MAPK Signaling Pathway
    Toll-like receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway

    3 Sino Biological Pathways for RIPK1
        TNF Signaling
    Death Receptor Signaling
    NF-kB (NFkB) Pathway

    Selected Reactome Pathways for RIPK1 (see all 8)
        NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
    IKK complex recruitment mediated by RIP1
    TNF signaling
    TRIF-mediated programmed cell death
    Caspase-8 activation


    Selected Kegg Pathways  (Kegg details for RIPK1) (see all 8):
        NF-kappa B signaling pathway
    Apoptosis
    Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway


    RIPK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RIPK1 (see all 8): 
              Antiviral Response in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Antibacterial Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RIPK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RIPK1 (Q135461, 2, 3 ENSP000002598084) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074372, 3MINT-49051 I2D: score=2 
    ENSG00000224156P074372, 3MINT-49051 I2D: score=2 
    ENSG00000227739P074372, 3MINT-49051 I2D: score=2 
    ENSG00000229684P074372, 3MINT-49051 I2D: score=2 
    ENSG00000232421P074372, 3MINT-49051 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation IMP17389591
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process TAS--

    RIPK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for RIPK1
      Browse compounds at ApexBio 

    Browse Tocris compounds for RIPK1

    2 HMDB Compounds for RIPK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for RIPK1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-2 64 3 15327770 (1), 17449468 (1)
    geldanamycin 57.1 11 10744744 (2), 16289096 (1), 17951993 (1)
    cycloheximide 16.5 3 10919673 (2)
    threonine 16.4 3 11369754 (1), 15178406 (1)
    adriamycin 15.1 2 19967054 (1)
    serine 5.08 3 11369754 (1), 15178406 (1)
    actinomycin d 2.71 3 10919673 (2)
    estrogen 1.49 3 9115274 (1), 10731120 (1)
    phosphatidylinositol 0.0487 3 15115707 (2), 15128824 (1)
    atp 0 2 18566385 (2)



    RIPK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RIPK1 gene: 
    NM_003804.3  

    Unigene Cluster for RIPK1:

    Receptor (TNFRSF)-interacting serine-threonine kinase 1
    Hs.519842  [show with all ESTs]
    Unigene Representative Sequence: AB208926
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479389 ENST00000259808(uc003muv.4 uc010jni.3 uc003mux.3 uc011dhs.2)
    ENST00000541791 ENST00000380409
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    4 qRT-PCR Assays for microRNAs that regulate RIPK1:
    hsa-miR-942 hsa-miR-1323 hsa-miR-548o hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidRIPK1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RIPK1 (NM_003804)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIPK1
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      QuantiFast Probe-based Assays in human, mouse, rat RIPK1

    Additional mRNA sequence: 

    AB208926.1 AJ420482.1 AK096523.1 AK304701.1 AK314176.1 BC126254.1 BC126256.1 U25994.1 
    U50062.1 

    16 DOTS entries:

    DT.100784005  DT.121404150  DT.87016751  DT.92001506  DT.101961566  DT.121404152  DT.91852686  DT.40252326 
    DT.70103908  DT.75144380  DT.92003526  DT.100697993  DT.95201652  DT.99984545  DT.91915627  DT.95128638 

    Selected AceView cDNA sequences (see all 150):

    AI174323 BM722050 AL039269 AL521376 AI420474 AI801478 AI611751 AK096523 
    CB159581 AA294820 Z43667 AI754860 CA748651 BF436924 AI380341 BX436346 
    AI971246 CR618624 AI538489 AI418080 Z39725 BM722088 AI520889 CA425127 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RIPK1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                      -                                                   
    SP2:                          -           -                                                   
    SP3:                                                                                          
    SP4:                                                                                          


    ECgene alternative splicing isoforms for RIPK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RIPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTTCAGC
    RIPK1 Expression
    About this image


    RIPK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RIPK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RIPK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519842
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RIPK1 (see all 8): 
              Antiviral Response in human mouse rat
              Apoptosis in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Antibacterial Response in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIPK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RIPK1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ripk11 , 5 receptor (TNFRSF)-interacting serine-threonine kinase more1, 5 79.08(n)1
    71.6(a)1
      13 (14.01 cM)5
    197661  NM_009068.31  NP_033094.31 
     340023635 
    chicken
    (Gallus gallus)
    Aves RIPK11 receptor (TNFRSF)-interacting serine-threonine kinase more 60.05(n)
    51.64(a)
      378921  NM_204402.1  NP_989733.1 
    lizard
    (Anolis carolinensis)
    Reptilia RIPK16
    receptor (TNFRSF)-interacting serine-threonine kin...
    47(a)
    1 ↔ 1
    GL343247.1(964569-998113)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ripk11 receptor (TNFRSF)-interacting serine-threonine kinase more 56(n)
    48.73(a)
      779958  NM_001079035.1  NP_001072503.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ripk1l1 receptor (TNFRSF)-interacting serine-threonine kinase more 51.71(n)
    43.09(a)
      567460  NM_001043350.1  NP_001036815.1 


    ENSEMBL Gene Tree for RIPK1 (if available)
    TreeFam Gene Tree for RIPK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RIPK1 gene
    RIPK32  RIPK42  RIPK22  ANKK12  

    RIPK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RIPK1 (see all 1111)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0410404
    A colorectal adenocarcinoma sample4--see VAR_0410402 V I mis40--------
    VAR_0410414
    A colorectal adenocarcinoma sample4--see VAR_0410412 A V mis40--------
    VAR_0410394
    A colorectal adenocarcinoma sample4--see VAR_0410392 A V mis40--------
    rs1918456841,2
    --3075214(+) CAGCCA/GGGATG 1 -- us2k10--------
    rs1503703201,2
    --3075247(+) CATCCA/GTAGCC 1 -- us2k10--------
    rs1379421411,2
    --3075266(+) ACTCTC/TAAAGC 1 -- us2k10--------
    rs1494547801,2
    --3075284(+) AGACAC/TGCACA 1 -- us2k10--------
    rs1828647911,2
    --3075285(+) GACACA/GCACAT 1 -- us2k10--------
    rs23261731,2
    C,F,O,A,H--3075553(+) GGGGAG/AAATGA 1 -- us2k134Minor allele frequency- A:0.50NS EA NA WA CSA 3516
    rs175132701,2
    C,F--3075554(+) GGGAGA/TATGAA 1 -- us2k12Minor allele frequency- T:0.02NS 94

    HapMap Linkage Disequilibrium report for RIPK1 (3064225 - 3115421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RIPK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1036383CNV Deletion17803354
    esv23861CNV Loss19812545
    nsv883404CNV Loss21882294
    esv25797CNV Gain19812545
    nsv883403CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RIPK1
    DNA2.0 Custom Variant and Variant Library Synthesis for RIPK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603453    OMIM disorders: --

    Selected diseases for RIPK1 (see all 36):    
    About MalaCards
    oral lichen planus    malt lymphoma    lichen planus    burkitt's lymphoma
    protein s deficiency    diffuse large b-cell lymphoma    anaplastic large cell lymphoma    b-cell lymphomas
    glomerulonephritis    myelodysplastic syndromes    non-hodgkin lymphoma    hodgkin's lymphoma
    oral squamous cell carcinoma    acute leukemia    hepatitis c    chronic lymphocytic leukemia
    squamous cell carcinoma    ischemia    systemic lupus erythematosus    esophageal squamous cell carcinoma


    RIPK1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for RIPK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 72.4 43 18566385 (3), 10744744 (2), 15572679 (2), 11369754 (2) (see all 25)
    tumors 54.4 38 15121855 (2), 10744744 (2), 11369754 (2), 15572679 (2) (see all 23)
    colon cancer 23.7 1 16825191 (1)
    inflammation 18.2 1 17222914 (1)
    burkitt lymphoma 11.5 1 10409763 (1)
    leukemia 0 2 9375749 (1)
    shock 0 2 17222914 (1), 16424045 (1)
    breast cancer 0 1 16459337 (1)
    lymphoma 0 2 9375749 (1)

    Genetic Association Database (GAD): RIPK1
    Human Genome Epidemiology (HuGE) Navigator: RIPK1 (15 documents)

    Export disorders for RIPK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RIPK1 gene, integrated from 10 sources (see all 354):
    (articles sorted by number of sources associating them with RIPK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PubMed id 8612133)1, 2, 3, 9 Hsu H.... Goeddel D.V. (Immunity 1996)
    2. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. (PubMed id 7538908)1, 2, 3 Stanger B.Z.... Seed B. (Cell 1995)
    3. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PubMed id 11734559)1, 2, 9 Sun X.... Dixit V.M. (J. Biol. Chem. 2002)
    4. The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. (PubMed id 10409763)1, 2, 9 Izumi K.M....Kieff E.D. (Mol. Cell. Biol. 1999)
    5. RIP3, a novel apoptosis-inducing kinase. (PubMed id 10358032)1, 2, 9 Sun X.... Dixit V.M. (J. Biol. Chem. 1999)
    6. CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation. (PubMed id 18450452)1, 2, 9 Liao W....Srinivasula S.M. (Curr. Biol. 2008)
    7. The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome. (PubMed id 11116146)1, 2, 9 Habib A.A....Vartanian T. (J. Biol. Chem. 2001)
    8. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. (PubMed id 10356400)1, 2, 9 Sanz L.... Moscat J. (EMBO J. 1999)
    9. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. (PubMed id 11101870)1, 2, 9 Holler N.... Tschopp J. (Nat. Immunol. 2000)
    10. Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma. (PubMed id 18990758)1, 4, 9 Cerhan J.R....Slager S.L. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8737 HGNC: 10019 AceView: RIPK1 Ensembl:ENSG00000137275 euGenes: HUgn8737
    ECgene: RIPK1 Kegg: 8737 H-InvDB: RIPK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RIPK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RIPK1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ripk1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RIPK1 gene:
    Search GeneIP for patents involving RIPK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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