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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIOK3 Gene

protein-coding   GIFtS: 51
GCID: GC18P021032

RIO kinase 3

(Previous names: sudD (suppressor of bimD6, Aspergillus nidulans) homolog,...)
(Previous symbol: SUDD)
 Explore 2 diseases affiliated with
RIOK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RIOK3    

Aliases
for RIOK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RIO Kinase 31 2 3     Homolog Of The Aspergillus Nidulans SudD Gene Product2
SUDD1 2 3 5     Serine/Threonine-Protein Kinase RIO32
SudD (Suppressor Of BimD6, Aspergillus Nidulans) Homolog1 2     SudD Suppressor Of Aspergillus Nidulans BimD6 Homolog2
SudD Homolog2 3     SudD Suppressor Of BimD6 Homolog2
RIO Kinase 3 (Yeast)1     EC 2.7.11.13

External Ids:    HGNC: 114511   Entrez Gene: 87802   Ensembl: ENSG000001017827   OMIM: 6035795   UniProtKB: O147303   

Export aliases for RIOK3 gene to outside databases

Previous GC identifers: GC18P020920 GC18P019285 GC18P019287 GC18P017887


Summaries
for RIOK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RIOK3:
This gene was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic
suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a
restrictive temperature. The specific function of this gene has not yet been determined. (provided by RefSeq, Jul
2008)




Genomic Views
for RIOK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010966.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIOK3 gene promoter:
         NF-YA   NF-YC   CUTL1   CBF-C   NF-YB   FOXO4   SEF-1 (1)   CP1A   CP1C   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RIOK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIOK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIOK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q11.2   HGNC cytogenetic band: 18q11.2

RIOK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIOK3 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P021032:  view genomic region     (about GC identifiers)

Start:
 21,032,787 bp from pter      End:
 21,066,567 bp from pter
Size:
 33,781 bases      Orientation:
 plus strand

Proteins
for RIOK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RIOK3_HUMAN, O14730 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase RIO3  
Size: 519 amino acids; 59093 Da
Secondary accessions: Q8IXN9
Alternative splicing: 2 isoforms:  O14730-1   O14730-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIOK3: NX_O14730

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14730

    • RIOK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003822.2  
    ENSEMBL proteins: 
     ENSP00000341874   ENSP00000463660   ENSP00000462548   ENSP00000463791   ENSP00000463644  

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    Novus Biologicals RIOK3 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RIOK3


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    Uscn ELISAs and CLIAs for RIOK3

    Protein Domains /
    Families
    for RIOK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RIOK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017406 Ser/Thr_kinase_Rio3
     IPR018934 RIO-like_kinase
     IPR000687 RIO_kinase
     IPR011009 Kinase-like_dom
     IPR018935 RIO_kinase_CS

    Graphical View of Domain Structure for InterPro Entry O14730

    ProtoNet protein and cluster: O14730

    1 Blocks protein family: IPB000687 Protein of unknown function RIO1

    UniProtKB/Swiss-Prot: RIOK3_HUMAN, O14730
    Similarity: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family
    Similarity: Contains 1 protein kinase domain


    Function
    for RIOK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RIOK3_HUMAN, O14730
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

    Enzyme Number (IUBMB): EC 2.7.11.11

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIOK3
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate RIOK3 (see all 33):
    hsa-let-7d hsa-miR-29a hsa-miR-30d hsa-let-7g hsa-miR-30a hsa-let-7a hsa-miR-186 hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmid: RIOK3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIOK3 (see all 7)
    OriGene shRNA RFP: RIOK3
    OriGene siRNA: RIOK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIOK3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RIOK3

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for RIOK3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIOK3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    RIOK3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for RIOK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c 


    Pathways & Interactions
    for RIOK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIOK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for RIOK3 (O147301, 3 ENSP000003418744) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM3P621583, ENSP000002912954I2D: score=2 STRING: ENSP00000291295
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    FBLP220873, ENSP000002218014I2D: score=2 STRING: ENSP00000221801
    PSMB1P206183, ENSP000002621934I2D: score=2 STRING: ENSP00000262193
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007059chromosome segregation TAS9602165


    RIOK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RIOK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIOK3

    2 HMDB Compounds for RIOK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Search CenterWatch for drugs/clinical trials and news about RIOK3 

    Transcripts
    for RIOK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RIOK3 gene (2 alternative transcripts): 
    NM_003831.3  NM_145906.1  

    Unigene Cluster for RIOK3:

    RIO kinase 3
    Hs.743988  [show with all ESTs]
    Unigene Representative Sequence: NM_003831
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339486(uc002kui.4 uc010dls.3 uc010xas.2 uc010xat.2)
    ENST00000584960 ENST00000581585 ENST00000584052 ENST00000581302 ENST00000577501
    ENST00000584992 ENST00000584130 ENST00000581339 ENST00000577250 ENST00000581220


    miRNA
    Products:             		 OriGene 3'-UTR Clone: RIOK3
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIOK3
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate RIOK3 (see all 33):
    hsa-let-7d hsa-miR-29a hsa-miR-30d hsa-let-7g hsa-miR-30a hsa-let-7a hsa-miR-186 hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmid: RIOK3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIOK3 (see all 7)
    OriGene shRNA RFP: RIOK3
    OriGene siRNA: RIOK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIOK3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIOK3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RIOK3 (NM_003831)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIOK3 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIOK3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIOK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIOK3

    Additional cDNA sequence: 

    AF013591.1 AK057292.1 AK303938.1 AK304571.1 AK310783.1 BC039729.1 

    18 DOTS entries:

    DT.455721  DT.91768972  DT.92410144  DT.91768944  DT.121085788  DT.100813622  DT.75198847  DT.97785607 
    DT.121085755  DT.121085760  DT.121085763  DT.121085773  DT.40196089  DT.86840335  DT.91768946  DT.95370701 
    DT.107958  DT.75106689 

    24/236 AceView cDNA sequences (see all 236):

    BC028360 AA489485 AA760632 CA441889 AA397584 BC039729 BM451832 T51070 
    NM_003831 AI823705 AK057292 AU120927 BQ082309 CB133369 N41775 CB242096 
    AA732512 CB135939 H69826 AI911181 NM_145906 BE017970 AA830657 AW300496 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RIOK3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                -     -           -                                                                                             
    SP2:                                -     -           -                                                                       -                     
    SP3:                                                                                -           -                                                   
    SP4:                                                                                                                                                
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for RIOK3

    Expression
    for RIOK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIOK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCCTATTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RIOK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeRetinaEye
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RIOK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIOK3

    SOURCE GeneReport for Unigene cluster: Hs.743988

    UniProtKB/Swiss-Prot: RIOK3_HUMAN, O14730
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for RIOK3
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    In Situ
    Assay Products:     
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    Orthologs
    for RIOK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for RIOK3 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RIOK31 RIO kinase 3 (yeast) 80.18(n)
    87.52(a)    		   421074  XM_419160.3  XP_419160.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RIOK36
    		 --
    		 82(a)
    		 1 ↔ 1
    		 4(38289966-38300304)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC685552 hypothetical protein MGC68555 80.04(n)    BC060398.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb10c112 Transcribed sequence with moderate similarity to protein more 78.06(n)    BI984728.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG30081 CG3008 51.14(n)
    48.35(a)    		   33693  NM_135027.3  NP_608871.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea riok-31 Protein RIOK-3 48.88(n)
    39.44(a)    		   176387  NM_066772.6  NP_499173.1 


    ENSEMBL Gene Tree for RIOK3 (if available)
    TreeFam Gene Tree for RIOK3 (if available) 

    Paralogs
    for RIOK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIOK3 gene
    RIOK12  
    1 SIMAP similar gene for RIOK3 using alignment to 6 protein entries:     RIOK3_HUMAN (see all proteins):
    RIOK1

    RIOK3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RIOK3
    PGOHUM00000248633


    Genomic Variants
    for RIOK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/583 NCBI SNPs in RIOK3 are shown (see all 583)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1902140561,2
    		--21030845(+) ACTGCA/CCTCCA 1 -- us2k10--------
    rs48004811,2
    		C,A,H,--21030851(+) CTCCAG/ACCTGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs454758921,2
    		F--21031116(+) TACTCT/GAAGGA 1 -- us2k11Minor allele frequency- G:0.06NS 32
    rs734064581,2
    		C,--21031208(+) GCCAAT/CGCGGG 1 -- us2k13Minor allele frequency- C:0.32WA CSA EA 123
    rs1819028141,2
    		--21031308(+) TGGCAA/CGCGCC 1 -- us2k10--------
    rs1142200751,2
    		F,--21031323(+) GTCCCA/GCCTAC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1864255551,2
    		--21031331(+) TACTCA/GGAAGG 1 -- us2k10--------
    rs1481003981,2
    		--21031400(+) GCCACC/TGCACT 1 -- us2k10--------
    rs454582061,2
    		F--21031489(+) AAAAGT/GTAAAA 1 -- us2k11Minor allele frequency- G:0.27NS 26
    rs456215361,2
    		F--21031491(+) AAGTTA/G/TAAAAA 1 -- us2k11NS 26

    HapMap Linkage Disequilibrium report for RIOK3 (21032787 - 21066567 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RIOK3
         1 CNV: 47911

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    Disorders / Diseases
    for RIOK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RIOK3 for disorders           About GeneDecksing

    OMIM gene information: 603579    OMIM disorders: --

    2 diseases for RIOK3:    About MalaCards
    melanoma    alcoholism


    Export disorders for RIOK3 gene to outside databases

    Publications
    for RIOK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIOK3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RIOK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the Aspergillus nidulans sudD gene and its human homologue. (PubMed id 9602165)1, 2, 3, 9 Anaya P.... May G.S. (1998)
    2. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. (PubMed id 19050074)1, 9 Kimmelman A.C....DePinho R.A. (2008)
    5. Human RioK3 is a novel component of cytoplasmic pre-40 S pre-ribosomal particles. (PubMed id 22418843)1 Baumas K....Mougin A. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for RIOK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing RIOK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8780 HGNC: 11451 AceView: RIOK3 Ensembl:ENSG00000101782 euGenes: HUgn8780
    ECgene: RIOK3 H-InvDB: RIOK3

    Other Databases showing RIOK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RIOK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIOK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RIOK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RIOK3 gene:
    Search GeneIP for patents involving RIOK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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