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Aliases for RIOK3 Gene

Aliases for RIOK3 Gene

  • RIO Kinase 3 2 3 4
  • SUDD 3 4 6
  • SudD (Suppressor Of BimD6, Aspergillus Nidulans) Homolog 2 3
  • SudD Homolog 3 4
  • Homolog Of The Aspergillus Nidulans SudD Gene Product 3
  • SudD Suppressor Of Aspergillus Nidulans BimD6 Homolog 3
  • Serine/Threonine-Protein Kinase RIO3 3
  • SudD Suppressor Of BimD6 Homolog 3
  • RIO Kinase 3 (Yeast) 2
  • EC 4

External Ids for RIOK3 Gene

Previous HGNC Symbols for RIOK3 Gene

  • SUDD

Previous GeneCards Identifiers for RIOK3 Gene

  • GC18P020920
  • GC18P019285
  • GC18P019287
  • GC18P021032
  • GC18P017887

Summaries for RIOK3 Gene

Entrez Gene Summary for RIOK3 Gene

  • This gene was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIOK3 Gene

RIOK3 (RIO Kinase 3) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is RIOK1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK3 Gene

Genomics for RIOK3 Gene

Regulatory Elements for RIOK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIOK3 Gene

23,452,823 bp from pter
23,486,603 bp from pter
33,781 bases
Plus strand

Genomic View for RIOK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK3 Gene

Proteins for RIOK3 Gene

  • Protein details for RIOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase RIO3
    Protein Accession:
    Secondary Accessions:
    • Q8IXN9

    Protein attributes for RIOK3 Gene

    519 amino acids
    Molecular mass:
    59093 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RIOK3 Gene


neXtProt entry for RIOK3 Gene

Proteomics data for RIOK3 Gene at MOPED

Post-translational modifications for RIOK3 Gene

  • Ubiquitination at Lys108, Lys160, Lys207, Lys290, Lys300, Lys452, and Lys456
  • Modification sites at PhosphoSitePlus

Other Protein References for RIOK3 Gene

Antibody Products

No data available for DME Specific Peptides for RIOK3 Gene

Domains for RIOK3 Gene

Gene Families for RIOK3 Gene

Graphical View of Domain Structure for InterPro Entry



  • O14730
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
genes like me logo Genes that share domains with RIOK3: view

Function for RIOK3 Gene

Molecular function for RIOK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for RIOK3 Gene

Gene Ontology (GO) - Molecular Function for RIOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 21988832
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with RIOK3: view

Phenotypes for RIOK3 Gene

genes like me logo Genes that share phenotypes with RIOK3: view

Animal Model Products

CRISPR Products

miRNA for RIOK3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIOK3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RIOK3 Gene

Localization for RIOK3 Gene

Subcellular locations from

Jensen Localization Image for RIOK3 Gene COMPARTMENTS Subcellular localization image for RIOK3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RIOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RIOK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RIOK3 Gene

Pathways for RIOK3 Gene

SuperPathways for RIOK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007059 chromosome segregation TAS 9602165
GO:0008152 metabolic process --
GO:0009103 lipopolysaccharide biosynthetic process --
genes like me logo Genes that share ontologies with RIOK3: view

No data available for Pathways by source for RIOK3 Gene

Compounds for RIOK3 Gene

(2) HMDB Compounds for RIOK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with RIOK3: view

Transcripts for RIOK3 Gene

Unigene Clusters for RIOK3 Gene

RIO kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIOK3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - -
SP6: -
SP7: - -

Relevant External Links for RIOK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIOK3 Gene

mRNA expression in normal human tissues for RIOK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RIOK3 Gene

This gene is overexpressed in Breast (35.1) and Cervix (27.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIOK3 Gene

SOURCE GeneReport for Unigene cluster for RIOK3 Gene Hs.728452

mRNA Expression by UniProt/SwissProt for RIOK3 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RIOK3: view

Expression partners for RIOK3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RIOK3 Gene

Orthologs for RIOK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIOK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RIOK3 35
  • 94.8 (n)
  • 95.95 (a)
RIOK3 36
  • 96 (a)
(Canis familiaris)
Mammalia RIOK3 35
  • 94.61 (n)
  • 96.34 (a)
RIOK3 36
  • 96 (a)
(Mus musculus)
Mammalia Riok3 35
  • 90.12 (n)
  • 94.19 (a)
Riok3 16
Riok3 36
  • 94 (a)
(Pan troglodytes)
Mammalia RIOK3 35
  • 99.81 (n)
  • 99.81 (a)
RIOK3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Riok3 35
  • 88.82 (n)
  • 94.03 (a)
(Monodelphis domestica)
Mammalia RIOK3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RIOK3 36
  • 89 (a)
(Gallus gallus)
Aves RIOK3 35
  • 80.18 (n)
  • 87.52 (a)
RIOK3 36
  • 86 (a)
(Anolis carolinensis)
Reptilia RIOK3 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia riok3 35
  • 72.45 (n)
  • 77.51 (a)
Str.17119 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68555 35
(Danio rerio)
Actinopterygii riok3 35
  • 70.66 (n)
  • 76.45 (a)
wufb10c11 35
riok3 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009993 35
  • 49.85 (n)
  • 48.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3008 35
  • 51.73 (n)
  • 49.32 (a)
CG3008 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea riok-3 35
  • 48.44 (n)
  • 39.33 (a)
riok-3 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO1 36
  • 25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8977 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for RIOK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK3 Gene

Gene Tree for RIOK3 (if available)
Gene Tree for RIOK3 (if available)

Paralogs for RIOK3 Gene

Paralogs for RIOK3 Gene

Selected SIMAP similar genes for RIOK3 Gene using alignment to 6 proteins: Pseudogenes for RIOK3 Gene

genes like me logo Genes that share paralogs with RIOK3: view

Variants for RIOK3 Gene

Sequence variations from dbSNP and Humsavar for RIOK3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1061806 -- 23,453,370(+) CCTGT(C/G)TCCTC utr-variant-5-prime
rs1061811 -- 23,481,899(+) CTTAT(A/G)TCTAA utr-variant-3-prime
rs1501412 -- 23,474,354(+) CTCCC(A/G)AGACC intron-variant
rs1801991 -- 23,481,427(+) CCAGA(A/T)GTGTG utr-variant-3-prime
rs1801992 -- 23,464,046(+) AGATG(G/T)AATAT reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for RIOK3 Gene

Variant ID Type Subtype PubMed ID
esv34149 CNV Loss 18971310
nsv909458 CNV Gain 21882294
esv2716859 CNV Deletion 23290073
esv2716860 CNV Deletion 23290073

Relevant External Links for RIOK3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOK3 Gene

Disorders for RIOK3 Gene

No disorders were found for RIOK3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RIOK3 Gene

Publications for RIOK3 Gene

  1. Isolation of the Aspergillus nidulans sudD gene and its human homologue. (PMID: 9602165) Anaya P. … May G.S. (Gene 1998) 2 3 4 23
  2. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. (PMID: 19050074) Kimmelman A.C. … DePinho R.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 3 4
  5. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3

Products for RIOK3 Gene

  • Addgene plasmids for RIOK3

Sources for RIOK3 Gene

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