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Aliases for RIOK3 Gene

Aliases for RIOK3 Gene

  • RIO Kinase 3 2 3 4 5
  • SudD (Suppressor Of BimD6, Aspergillus Nidulans) Homolog 2 3
  • SudD Homolog 3 4
  • SUDD 3 4
  • Homolog Of The Aspergillus Nidulans SudD Gene Product 3
  • SudD Suppressor Of Aspergillus Nidulans BimD6 Homolog 3
  • Testicular Secretory Protein Li 47 3
  • SudD Suppressor Of BimD6 Homolog 3
  • RIO Kinase 3 (Yeast) 2
  • EC 4

External Ids for RIOK3 Gene

Previous HGNC Symbols for RIOK3 Gene

  • SUDD

Previous GeneCards Identifiers for RIOK3 Gene

  • GC18P020920
  • GC18P019285
  • GC18P019287
  • GC18P021032
  • GC18P017887

Summaries for RIOK3 Gene

Entrez Gene Summary for RIOK3 Gene

  • This gene was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIOK3 Gene

RIOK3 (RIO Kinase 3) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is RIOK1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK3 Gene

Genomics for RIOK3 Gene

Regulatory Elements for RIOK3 Gene

Enhancers for RIOK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RIOK3 on UCSC Golden Path with GeneCards custom track

Promoters for RIOK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RIOK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIOK3 Gene

23,452,823 bp from pter
23,486,603 bp from pter
33,781 bases
Plus strand

Genomic View for RIOK3 Gene

Genes around RIOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK3 Gene

Proteins for RIOK3 Gene

  • Protein details for RIOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase RIO3
    Protein Accession:
    Secondary Accessions:
    • Q8IXN9

    Protein attributes for RIOK3 Gene

    519 amino acids
    Molecular mass:
    59093 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RIOK3 Gene


neXtProt entry for RIOK3 Gene

Proteomics data for RIOK3 Gene at MOPED

Post-translational modifications for RIOK3 Gene

  • Ubiquitination at Lys 108, Lys 160, Lys 207, Lys 290, Lys 300, and Lys 452
  • Modification sites at PhosphoSitePlus

Other Protein References for RIOK3 Gene

Antibody Products

  • Abcam antibodies for RIOK3

No data available for DME Specific Peptides for RIOK3 Gene

Domains & Families for RIOK3 Gene

Gene Families for RIOK3 Gene

Protein Domains for RIOK3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
genes like me logo Genes that share domains with RIOK3: view

Function for RIOK3 Gene

Molecular function for RIOK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for RIOK3 Gene

Gene Ontology (GO) - Molecular Function for RIOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RIOK3: view
genes like me logo Genes that share phenotypes with RIOK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RIOK3

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIOK3 Gene

Localization for RIOK3 Gene

Subcellular locations from

Jensen Localization Image for RIOK3 Gene COMPARTMENTS Subcellular localization image for RIOK3 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
golgi apparatus 2
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIOK3 Gene

Pathways & Interactions for RIOK3 Gene

genes like me logo Genes that share pathways with RIOK3: view

Pathways by source for RIOK3 Gene

Gene Ontology (GO) - Biological Process for RIOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
genes like me logo Genes that share ontologies with RIOK3: view

No data available for SIGNOR curated interactions for RIOK3 Gene

Drugs & Compounds for RIOK3 Gene

No Compound Related Data Available

Transcripts for RIOK3 Gene

Unigene Clusters for RIOK3 Gene

RIO kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - -
SP6: -
SP7: - -

Relevant External Links for RIOK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIOK3 Gene

mRNA expression in normal human tissues for RIOK3 Gene

Protein differential expression in normal tissues from HIPED for RIOK3 Gene

This gene is overexpressed in Breast (35.1) and Cervix (27.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIOK3 Gene

SOURCE GeneReport for Unigene cluster for RIOK3 Gene Hs.728452

mRNA Expression by UniProt/SwissProt for RIOK3 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RIOK3: view

Protein tissue co-expression partners for RIOK3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RIOK3 Gene

Orthologs for RIOK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIOK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RIOK3 35
  • 94.8 (n)
  • 95.95 (a)
RIOK3 36
  • 96 (a)
(Canis familiaris)
Mammalia RIOK3 35
  • 94.61 (n)
  • 96.34 (a)
RIOK3 36
  • 96 (a)
(Mus musculus)
Mammalia Riok3 35
  • 90.12 (n)
  • 94.19 (a)
Riok3 16
Riok3 36
  • 94 (a)
(Pan troglodytes)
Mammalia RIOK3 35
  • 99.81 (n)
  • 99.81 (a)
RIOK3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Riok3 35
  • 88.82 (n)
  • 94.03 (a)
(Monodelphis domestica)
Mammalia RIOK3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RIOK3 36
  • 89 (a)
(Gallus gallus)
Aves RIOK3 35
  • 80.18 (n)
  • 87.52 (a)
RIOK3 36
  • 86 (a)
(Anolis carolinensis)
Reptilia RIOK3 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia riok3 35
  • 72.45 (n)
  • 77.51 (a)
Str.17119 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68555 35
(Danio rerio)
Actinopterygii riok3 35
  • 70.66 (n)
  • 76.45 (a)
wufb10c11 35
riok3 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009993 35
  • 49.85 (n)
  • 48.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3008 35
  • 51.73 (n)
  • 49.32 (a)
CG3008 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea riok-3 35
  • 48.44 (n)
  • 39.33 (a)
riok-3 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO1 36
  • 25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8977 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for RIOK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK3 Gene

Gene Tree for RIOK3 (if available)
Gene Tree for RIOK3 (if available)

Paralogs for RIOK3 Gene

Paralogs for RIOK3 Gene

(1) SIMAP similar genes for RIOK3 Gene using alignment to 6 proteins: Pseudogenes for RIOK3 Gene

genes like me logo Genes that share paralogs with RIOK3: view

Variants for RIOK3 Gene

Sequence variations from dbSNP and Humsavar for RIOK3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs35401850 - 23,473,619(+) ACAAT(C/G)TCGCA intron-variant, reference, missense
rs33969048 - 23,477,246(+) GTTCC(A/G)GGACT reference, missense
rs56282762 - 23,477,264(+) TGTCT(C/T)GCAGG reference, missense
rs4800160 -- 23,451,778(+) GAGTG(C/T)AGTGG upstream-variant-2KB
rs4800161 -- 23,459,734(+) ggcgc(A/G)atctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIOK3 Gene

Variant ID Type Subtype PubMed ID
esv34149 CNV Loss 18971310
nsv909458 CNV Gain 21882294
esv2716859 CNV Deletion 23290073
esv2716860 CNV Deletion 23290073

Variation tolerance for RIOK3 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.25% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RIOK3 Gene

Disorders for RIOK3 Gene

Relevant External Links for RIOK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RIOK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIOK3 Gene

Publications for RIOK3 Gene

  1. Isolation of the Aspergillus nidulans sudD gene and its human homologue. (PMID: 9602165) Anaya P. … May G.S. (Gene 1998) 2 3 4 23 67
  2. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. (PMID: 19050074) Kimmelman A.C. … DePinho R.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  3. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. (PMID: 25486436) Singleton D.C. … Harris A.L. (Oncogene 2015) 3
  4. RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response. (PMID: 25865883) Takashima K. … Seya T. (Cell Rep 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for RIOK3 Gene

Sources for RIOK3 Gene