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Aliases for RIOK3 Gene

Aliases for RIOK3 Gene

  • RIO Kinase 3 2 3 4 5
  • SudD (Suppressor Of BimD6, Aspergillus Nidulans) Homolog 2 3
  • SudD Homolog 3 4
  • SUDD 3 4
  • Homolog Of The Aspergillus Nidulans SudD Gene Product 3
  • SudD Suppressor Of Aspergillus Nidulans BimD6 Homolog 3
  • Serine/Threonine-Protein Kinase RIO3 3
  • Testicular Secretory Protein Li 47 3
  • SudD Suppressor Of BimD6 Homolog 3
  • RIO Kinase 3 (Yeast) 2
  • EC 2.7.11.1 4

External Ids for RIOK3 Gene

Previous HGNC Symbols for RIOK3 Gene

  • SUDD

Previous GeneCards Identifiers for RIOK3 Gene

  • GC18P020920
  • GC18P019285
  • GC18P019287
  • GC18P021032
  • GC18P017887

Summaries for RIOK3 Gene

Entrez Gene Summary for RIOK3 Gene

  • This gene was identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. The specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIOK3 Gene

RIOK3 (RIO Kinase 3) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is RIOK1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK3 Gene

Genomics for RIOK3 Gene

Regulatory Elements for RIOK3 Gene

Enhancers for RIOK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F023420 1.6 FANTOM5 Ensembl ENCODE 12 -30.3 -30316 3.3 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF207 FOS KLF13 JUNB TBX21 NPC1 C18orf8 RIOK3 CABLES1 RBBP8 TMEM241 ENSG00000266495
GH18F023279 1.1 Ensembl ENCODE 10.7 -170.3 -170280 6.6 HDGF PKNOX1 BMI1 RARA KAT2B ELK1 FOS USF2 CEBPB JUNB RIOK3 NPC1 ENSG00000266495 TMEM241
GH18F023478 0.8 Ensembl ENCODE 12.4 +27.4 27394 2.7 GATA3 IKZF1 MLLT1 SPI1 C18orf8 RIOK3 TMEM241 PIR55902 GC18P023472
GH18F023416 0.5 Ensembl 11.7 -36.2 -36223 0.4 ZNF316 IKZF1 EMSY RIOK3 TMEM241 ENSG00000266495
GH18F023484 0.5 ENCODE 11.6 +31.5 31453 0.3 ZNF121 POLR2A SUPT5H RIOK3 TMEM241 NPC1 ENSG00000283084 PIR55902
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIOK3 on UCSC Golden Path with GeneCards custom track

Promoters for RIOK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001513570 1077 2601 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS

Genomic Location for RIOK3 Gene

Chromosome:
18
Start:
23,452,823 bp from pter
End:
23,486,603 bp from pter
Size:
33,781 bases
Orientation:
Plus strand

Genomic View for RIOK3 Gene

Genes around RIOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK3 Gene

Proteins for RIOK3 Gene

  • Protein details for RIOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14730-RIOK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase RIO3
    Protein Accession:
    O14730
    Secondary Accessions:
    • Q8IXN9

    Protein attributes for RIOK3 Gene

    Size:
    519 amino acids
    Molecular mass:
    59093 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RIOK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIOK3 Gene

Post-translational modifications for RIOK3 Gene

  • Ubiquitination at Lys 108, Lys 160, Lys 207, Lys 290, Lys 300, and Lys 452
  • Modification sites at PhosphoSitePlus

Other Protein References for RIOK3 Gene

Antibody Products

  • Abcam antibodies for RIOK3

No data available for DME Specific Peptides for RIOK3 Gene

Domains & Families for RIOK3 Gene

Gene Families for RIOK3 Gene

Graphical View of Domain Structure for InterPro Entry

O14730

UniProtKB/Swiss-Prot:

RIOK3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
genes like me logo Genes that share domains with RIOK3: view

Function for RIOK3 Gene

Molecular function for RIOK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for RIOK3 Gene

Gene Ontology (GO) - Molecular Function for RIOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 21988832
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with RIOK3: view
genes like me logo Genes that share phenotypes with RIOK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RIOK3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RIOK3

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIOK3 Gene

Localization for RIOK3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIOK3 gene
Compartment Confidence
cytosol 5
plasma membrane 2
cytoskeleton 2
nucleus 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for RIOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RIOK3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RIOK3 Gene

Pathways & Interactions for RIOK3 Gene

genes like me logo Genes that share pathways with RIOK3: view

Gene Ontology (GO) - Biological Process for RIOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007059 chromosome segregation TAS 9602165
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with RIOK3: view

No data available for SIGNOR curated interactions for RIOK3 Gene

Transcripts for RIOK3 Gene

Unigene Clusters for RIOK3 Gene

RIO kinase 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RIOK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7: - -
SP8:

Relevant External Links for RIOK3 Gene

GeneLoc Exon Structure for
RIOK3
ECgene alternative splicing isoforms for
RIOK3

Expression for RIOK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RIOK3 Gene

Protein differential expression in normal tissues from HIPED for RIOK3 Gene

This gene is overexpressed in Breast (35.1) and Cervix (27.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIOK3 Gene



Protein tissue co-expression partners for RIOK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIOK3 Gene:

RIOK3

SOURCE GeneReport for Unigene cluster for RIOK3 Gene:

Hs.728452

mRNA Expression by UniProt/SwissProt for RIOK3 Gene:

O14730-RIOK3_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RIOK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RIOK3 Gene

Orthologs for RIOK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIOK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIOK3 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia RIOK3 34 35
  • 94.8 (n)
dog
(Canis familiaris)
Mammalia RIOK3 34 35
  • 94.61 (n)
oppossum
(Monodelphis domestica)
Mammalia RIOK3 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Riok3 34 16 35
  • 90.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RIOK3 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Riok3 34
  • 88.82 (n)
chicken
(Gallus gallus)
Aves RIOK3 34 35
  • 80.18 (n)
lizard
(Anolis carolinensis)
Reptilia RIOK3 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia riok3 34
  • 72.45 (n)
Str.17119 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68555 34
zebrafish
(Danio rerio)
Actinopterygii riok3 34 35
  • 70.66 (n)
wufb10c11 34
fruit fly
(Drosophila melanogaster)
Insecta CG3008 34 35
  • 51.73 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009993 34
  • 49.85 (n)
worm
(Caenorhabditis elegans)
Secernentea riok-3 34 35
  • 48.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO1 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8977 34
Species where no ortholog for RIOK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK3 Gene

ENSEMBL:
Gene Tree for RIOK3 (if available)
TreeFam:
Gene Tree for RIOK3 (if available)

Paralogs for RIOK3 Gene

Paralogs for RIOK3 Gene

(1) SIMAP similar genes for RIOK3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for RIOK3 Gene

genes like me logo Genes that share paralogs with RIOK3: view

Variants for RIOK3 Gene

Sequence variations from dbSNP and Humsavar for RIOK3 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1061806 -- 23,453,370(+) CCTGT(C/G)TCCTC utr-variant-5-prime
rs1061811 -- 23,481,899(+) CTTAT(A/G)TCTAA utr-variant-3-prime
rs11082515 -- 23,462,338(+) GTTTC(A/G)CCATG intron-variant
rs11082516 -- 23,462,422(+) AGGCG(C/T)GCGCC intron-variant
rs11082517 -- 23,463,236(+) ttgca(C/T)tggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIOK3 Gene

Variant ID Type Subtype PubMed ID
esv2716859 CNV deletion 23290073
esv2716860 CNV deletion 23290073
esv3337127 CNV duplication 20981092
esv34149 CNV loss 18971310

Variation tolerance for RIOK3 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIOK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIOK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOK3 Gene

Disorders for RIOK3 Gene

Relevant External Links for RIOK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIOK3

No disorders were found for RIOK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIOK3 Gene

Publications for RIOK3 Gene

  1. Isolation of the Aspergillus nidulans sudD gene and its human homologue. (PMID: 9602165) Anaya P. … May G.S. (Gene 1998) 2 3 4 22 64
  2. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. (PMID: 19050074) Kimmelman A.C. … DePinho R.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 22 64
  3. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. (PMID: 25486436) Singleton D.C. … Harris A.L. (Oncogene 2015) 3 64

Products for RIOK3 Gene

Sources for RIOK3 Gene

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