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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIOK2 Gene

protein-coding   GIFtS: 56
GCID: GC05M096496

RIO Kinase 2

(Previous name: RIO kinase 2 (yeast))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RIO Kinase 21 2 3
RIO Kinase 2 (Yeast)1
RIO22
Serine/Threonine-Protein Kinase RIO22
EC 2.7.11.13

External Ids:    HGNC: 189991   Entrez Gene: 557812   Ensembl: ENSG000000587297   UniProtKB: Q9BVS43   

Export aliases for RIOK2 gene to outside databases

Previous GC identifers: GC05M096525 GC05M096572 GC05M096570 GC05M096524 GC05M091686


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RIOK2 Gene: 
RIOK2 (RIO kinase 2) is a protein-coding gene. Diseases associated with RIOK2 include diamond-blackfan anemia, and anemia. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIOK2 gene promoter:
         CUTL1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-1   POU2F1   POU2F1b   FOXO4   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIOK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIOK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIOK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15   Ensembl cytogenetic band:  5q15   HGNC cytogenetic band: 5q14

RIOK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIOK2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M096496:  view genomic region     (about GC identifiers)

Start:
96,496,571 bp from pter      End:
96,519,005 bp from pter
Size:
22,435 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIOK2_HUMAN, Q9BVS4 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase RIO2  
Size: 552 amino acids; 63283 Da
Secondary accessions: D6RDI3 Q9NUT0
Alternative splicing: 2 isoforms:  Q9BVS4-1   Q9BVS4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIOK2: NX_Q9BVS4

Explore proteomics data for RIOK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BVS4

  • RIOK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIOK2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001153221.1  NP_060813.2  

    ENSEMBL proteins: 
     ENSP00000283109   ENSP00000421830   ENSP00000422772   ENSP00000420932   ENSP00000424325  

    Human Recombinant Protein Products for RIOK2: 
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    Novus Biologicals RIOK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIOK2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----

    RIOK2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: RIO kinase 2 (yeast) 
    RIO2 subfamily

    5 InterPro protein domains:
     IPR011009 Kinase-like_dom
     IPR018935 RIO_kinase_CS
     IPR015285 RIO2_kinase_winged_hlx_N
     IPR011991 WHTH_DNA-bd_dom
     IPR018934 RIO-like_kinase

    Graphical View of Domain Structure for InterPro Entry Q9BVS4

    ProtoNet protein and cluster: Q9BVS4

    1 Blocks protein domain: IPB000687 Protein of unknown function RIO1

    UniProtKB/Swiss-Prot: RIOK2_HUMAN, Q9BVS4
    Similarity: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family
    Similarity: Contains 1 protein kinase domain


    RIOK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIOK2_HUMAN, Q9BVS4
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
    GO:0016773phosphotransferase activity, alcohol group as acceptor ----
         
    RIOK2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RIOK2:
     Cytoplasmic 40S maturation def  Increased cell death HMECs cel  Increased cell death in breast  Increased homologous recombina 
     Stronger migration 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIOK2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIOK2 
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of RIOK2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIOK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RIOK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for RIOK2):
        Ribosome biogenesis in eukaryotes


    RIOK2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIOK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/138 Interacting proteins for RIOK2 (Q9BVS43 ENSP000002831094) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0009103lipopolysaccharide biosynthetic process ----

    RIOK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIOK2

    2 HMDB Compounds for RIOK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about RIOK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIOK2 gene (2 alternative transcripts): 
    NM_001159749.1  NM_018343.2  

    Unigene Cluster for RIOK2:

    RIO kinase 2
    Hs.27021  [show with all ESTs]
    Unigene Representative Sequence: NM_018343
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283109(uc003kmz.3) ENST00000511293 ENST00000511012 ENST00000508447(uc003kna.3)
    ENST00000508991 ENST00000511920 ENST00000510384
    miRNA
    Products:
         
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RIOK2:
    hsa-miR-579 hsa-miR-182* hsa-miR-3924
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIOK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIOK2
    Sirion Biotech Customized lentivirus for stable overexpression of RIOK2 
                         Customized lentivirus expression plasmids for stable overexpression of RIOK2 
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    OriGene qPCR primer pairs and template standards for RIOK2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIOK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIOK2

    Additional mRNA sequence: 

    AK001697.1 AK002021.1 AK225348.1 BC000953.2 

    7 DOTS entries:

    DT.111452  DT.100651609  DT.91689773  DT.100742598  DT.120869613  DT.120869711  DT.95163648 

    24/135 AceView cDNA sequences (see all 135):

    CA425714 BM677568 BC000953 BM759119 BM554462 CR610601 CR622281 BU784325 
    CA448205 CN485193 N51083 AI566080 BQ049234 BP365447 BX110904 Z42096 
    BI819237 Z38366 BU501701 BM762733 BE328484 BG611369 AA830666 BE387691 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RIOK2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:        -                                                               
    SP2:                                                                        


    ECgene alternative splicing isoforms for RIOK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIOK2 expression in normal human tissues (normalized intensities)      RIOK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RIOK2 Expression
    About this image


    RIOK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Testis (Reproductive System)
     
     Ovary (Reproductive System)

    See RIOK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIOK2

    SOURCE GeneReport for Unigene cluster: Hs.27021
        SABiosciences Custom PCR Arrays for RIOK2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIOK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RIOK2 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Riok21 , 5 RIO kinase 2 (yeast)1, 5 83.24(n)1
    83.73(a)1
      17 (9.77 cM)5
    670451  NM_025934.21  NP_080210.11 
     173743325 
    chicken
    (Gallus gallus)
    Aves RIOK21 RIO kinase 2 (yeast) 70.62(n)
    69.94(a)
      427278  NM_001006581.2  NP_001006581.2 
    lizard
    (Anolis carolinensis)
    Reptilia RIOK26
    Uncharacterized protein
    70(a)
    1 ↔ 1
    2(26693727-26711760)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16642 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_060813.1 (H.sapiens) hypothetical protein FLJ11159 [Homo sapiens] less 78.97(n)    CA790405.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.242472 Danio rerio mRNA similar to hypothetical protein FLJ11159 (cDNA clone MGC55376 IMAGE2601929), complete cds less 74.97(n)    BC047169.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118591 CG11859 51.64(n)
    47.98(a)
      43046  NM_143108.2  NP_651365.1 
    worm
    (Caenorhabditis elegans)
    Secernentea riok-21 Protein RIOK-2 51.46(n)
    45.63(a)
      173322  NM_061143.4  NP_493544.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RIO2(YNL207W)4
    RIO21
    Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p less4
    Rio2p1
    51.68(n)1
    45.24(a)1
      14(255353-256630)4
    8555141, 4  NP_014192.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G512701 RIO kinase 2 54.46(n)
    52.02(a)
      824290  NM_114986.2  NP_190695.2 
    rice
    (Oryza sativa)
    Liliopsida Os.144372 Oryza sativa (japonica cultivar-group) cDNA cloneJ033030B16, full insert sequence less 73.81(n)    AK119166.1 


    ENSEMBL Gene Tree for RIOK2 (if available)
    TreeFam Gene Tree for RIOK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIOK2 gene

    RIOK2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RIOK2
    PGOHUM00000243977


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/616 SNPs in RIOK2 are shown (see all 616)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423514
    A renal clear cell carcinoma sample4--see VAR_0423512 I T mis40--------
    rs1834092741,2
    --96496083(+) CATGGC/TTTTTC 1 -- int10--------
    rs309991,2
    C,F,A--96496150(+) TAAACT/GAAAGC 1 -- int19Minor allele frequency- G:0.07MN NA WA EA 688
    rs309981,2
    C,F,A,H--96496189(+) TCTCTA/CGGGAG 1 -- int127Minor allele frequency- C:0.07MN NS EA NA WA 3366
    rs1857603061,2
    --96496231(+) ATGGCC/GAACTG 1 -- int10--------
    rs1476598721,2
    --96496250(+) CCAGAA/GTGCTG 1 -- int10--------
    rs1152442831,2
    F--96496362(+) TCAGGC/AAGAGT 1 -- int11Minor allele frequency- A:0.01WA 118
    rs309971,2
    C,F,A,H--96496389(+) TATGTA/GTTTTG 1 -- int119Minor allele frequency- G:0.25NS EA WA CSA NA 2336
    rs1449551211,2
    --96496421(+) TGGCTA/GAAAGA 1 -- int10--------
    rs176298221,2
    C,F,H--96496437(+) TATCTC/TGAGCT 1 -- int118Minor allele frequency- T:0.02NA NS EA 1842

    HapMap Linkage Disequilibrium report for RIOK2 (96496571 - 96519005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RIOK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1385283CNV Insertion17803354
    nsv830413CNV Loss17160897
    nsv830412CNV Loss17160897
    nsv882393CNV Gain21882294
    dgv6220n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for RIOK2:    About MalaCards
    diamond-blackfan anemia    anemia    alcoholism

    1 disease from the University of Copenhagen DISEASES database for RIOK2:
    Diamond-Blackfan anemia

    RIOK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RIOK2
    Human Genome Epidemiology (HuGE) Navigator: RIOK2 (3 documents)

    Export disorders for RIOK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIOK2 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with RIOK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ERAP2 gene is associated with preeclampsia in Aus tralian and Norwegian populations. (PubMed id 19578876)1, 4 Johnson M.P....Moses E.K. (2009)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    6. A kinome-wide RNAi screen in Drosophila Glia reveals t hat the RIO kinases mediate cell proliferation and survival through TORC2-Akt si gnaling in glioblastoma. (PubMed id 23459592)1 Read R.D....Thomas J.B. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression. (PubMed id 21880710)1 Liu T....Ye X. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55781 HGNC: 18999 AceView: RIOK2 Ensembl:ENSG00000058729 euGenes: HUgn55781
    ECgene: RIOK2 Kegg: 55781 H-InvDB: RIOK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIOK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIOK2 gene:
    Search GeneIP for patents involving RIOK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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