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Aliases for RIOK2 Gene

Aliases for RIOK2 Gene

  • RIO Kinase 2 2 3 4
  • Serine/Threonine-Protein Kinase RIO2 3
  • RIO Kinase 2 (Yeast) 2
  • EC 2.7.11.1 4
  • RIO2 3

External Ids for RIOK2 Gene

Previous GeneCards Identifiers for RIOK2 Gene

  • GC05M096525
  • GC05M096572
  • GC05M096570
  • GC05M096524
  • GC05M096496
  • GC05M091686

Summaries for RIOK2 Gene

GeneCards Summary for RIOK2 Gene

RIOK2 (RIO Kinase 2) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include protein serine/threonine kinase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK2 Gene

Genomics for RIOK2 Gene

Genomic Location for RIOK2 Gene

Start:
97,160,867 bp from pter
End:
97,183,301 bp from pter
Size:
22,435 bases
Orientation:
Minus strand

Genomic View for RIOK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK2 Gene

Proteins for RIOK2 Gene

  • Protein details for RIOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVS4-RIOK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase RIO2
    Protein Accession:
    Q9BVS4
    Secondary Accessions:
    • D6RDI3
    • Q9NUT0

    Protein attributes for RIOK2 Gene

    Size:
    552 amino acids
    Molecular mass:
    63283 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RIOK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIOK2 Gene

Proteomics data for RIOK2 Gene at MOPED

Post-translational modifications for RIOK2 Gene

  • Ubiquitination at Lys86 and Lys288
  • Modification sites at PhosphoSitePlus

Other Protein References for RIOK2 Gene

No data available for DME Specific Peptides for RIOK2 Gene

Domains for RIOK2 Gene

Gene Families for RIOK2 Gene

Suggested Antigen Peptide Sequences for RIOK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVS4

UniProtKB/Swiss-Prot:

RIOK2_HUMAN :
  • Q9BVS4
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
genes like me logo Genes that share domains with RIOK2: view

Function for RIOK2 Gene

Molecular function for RIOK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for RIOK2 Gene

Gene Ontology (GO) - Molecular Function for RIOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
GO:0016773 phosphotransferase activity, alcohol group as acceptor --
genes like me logo Genes that share ontologies with RIOK2: view
genes like me logo Genes that share phenotypes with RIOK2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIOK2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RIOK2 Gene

Localization for RIOK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIOK2 Gene COMPARTMENTS Subcellular localization image for RIOK2 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RIOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RIOK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RIOK2 Gene

Pathways for RIOK2 Gene

genes like me logo Genes that share pathways with RIOK2: view

Pathways by source for RIOK2 Gene

1 KEGG pathway for RIOK2 Gene

Gene Ontology (GO) - Biological Process for RIOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0009103 lipopolysaccharide biosynthetic process --
genes like me logo Genes that share ontologies with RIOK2: view

Compounds for RIOK2 Gene

(2) HMDB Compounds for RIOK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with RIOK2: view

Transcripts for RIOK2 Gene

Unigene Clusters for RIOK2 Gene

RIO kinase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIOK2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:

Relevant External Links for RIOK2 Gene

GeneLoc Exon Structure for
RIOK2
ECgene alternative splicing isoforms for
RIOK2

Expression for RIOK2 Gene

mRNA expression in normal human tissues for RIOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIOK2 Gene

SOURCE GeneReport for Unigene cluster for RIOK2 Gene Hs.27021

genes like me logo Genes that share expressions with RIOK2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIOK2 Gene

Orthologs for RIOK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIOK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIOK2 35
  • 99.15 (n)
  • 99.09 (a)
RIOK2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RIOK2 35
  • 88.14 (n)
  • 87.11 (a)
RIOK2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIOK2 35
  • 88.14 (n)
  • 85.4 (a)
RIOK2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Riok2 35
  • 83.24 (n)
  • 83.73 (a)
Riok2 16
Riok2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RIOK2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Riok2 35
  • 82.64 (n)
  • 81.85 (a)
chicken
(Gallus gallus)
Aves RIOK2 35
  • 70.62 (n)
  • 69.94 (a)
RIOK2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIOK2 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1664 35
tropical clawed frog
(Silurana tropicalis)
Amphibia riok2 35
  • 67.66 (n)
  • 68.83 (a)
Str.2960 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24247 35
riok2 35
  • 68.21 (n)
  • 74.45 (a)
riok2 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001526 35
  • 51.32 (n)
  • 47.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11859 35
  • 52.24 (n)
  • 49.51 (a)
CG11859 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea riok-2 35
  • 58.97 (n)
  • 59.62 (a)
riok-2 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL166W 35
  • 51.78 (n)
  • 44.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO2 35
  • 52.59 (n)
  • 45.83 (a)
RIO2 36
  • 39 (a)
OneToOne
RIO2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19008g 35
  • 52.09 (n)
  • 45.07 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51270 35
  • 58.04 (n)
  • 58.58 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1543 35
corn
(Zea mays)
Liliopsida Zm.5985 35
rice
(Oryza sativa)
Liliopsida Os.14437 35
Os01g0888700 35
  • 59.61 (n)
  • 58.96 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07722 35
  • 53.92 (n)
  • 56.84 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1703.05 35
  • 58.74 (n)
  • 54.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToOne
Species with no ortholog for RIOK2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK2 Gene

ENSEMBL:
Gene Tree for RIOK2 (if available)
TreeFam:
Gene Tree for RIOK2 (if available)

Paralogs for RIOK2 Gene

Pseudogenes.org Pseudogenes for RIOK2 Gene

genes like me logo Genes that share paralogs with RIOK2: view

No data available for Paralogs for RIOK2 Gene

Variants for RIOK2 Gene

Sequence variations from dbSNP and Humsavar for RIOK2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs8654 -- 97,163,079(+) AAGCT(A/G)GCTGC reference, synonymous-codon
rs27310 -- 97,169,234(+) CTTCT(C/T)ATCAG intron-variant
rs27311 -- 97,169,404(+) CTATA(A/C)AAATA intron-variant
rs27312 -- 97,169,702(+) AACAT(C/T)TTCTA intron-variant
rs27614 -- 97,169,922(+) TCATG(A/T)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIOK2 Gene

Variant ID Type Subtype PubMed ID
nsv830412 CNV Loss 17160897
nsv830413 CNV Loss 17160897
dgv6220n71 CNV Gain 21882294
nsv882393 CNV Gain 21882294
esv1385283 CNV Insertion 17803354

Relevant External Links for RIOK2 Gene

HapMap Linkage Disequilibrium report
RIOK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOK2 Gene

Disorders for RIOK2 Gene

(1) University of Copenhagen DISEASES for RIOK2 Gene

Relevant External Links for RIOK2

Genetic Association Database (GAD)
RIOK2
Human Genome Epidemiology (HuGE) Navigator
RIOK2
genes like me logo Genes that share disorders with RIOK2: view

No data available for UniProtKB/Swiss-Prot for RIOK2 Gene

Publications for RIOK2 Gene

  1. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PMID: 19578876) Johnson M.P. … Moses E.K. (Hum. Genet. 2009) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2. (PMID: 19564402) Zemp I. … Kutay U. (J. Cell Biol. 2009) 3

Products for RIOK2 Gene

  • Addgene plasmids for RIOK2

Sources for RIOK2 Gene

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