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Aliases for RIOK2 Gene

Aliases for RIOK2 Gene

  • RIO Kinase 2 2 3 4 5
  • RIO Kinase 2 (Yeast) 2
  • EC 4
  • RIO2 3

External Ids for RIOK2 Gene

Previous GeneCards Identifiers for RIOK2 Gene

  • GC05M096525
  • GC05M096572
  • GC05M096570
  • GC05M096524
  • GC05M096496
  • GC05M091686

Summaries for RIOK2 Gene

GeneCards Summary for RIOK2 Gene

RIOK2 (RIO Kinase 2) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK2 Gene

Genomics for RIOK2 Gene

Regulatory Elements for RIOK2 Gene

Enhancers for RIOK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RIOK2 on UCSC Golden Path with GeneCards custom track

Promoters for RIOK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RIOK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIOK2 Gene

97,160,867 bp from pter
97,183,301 bp from pter
22,435 bases
Minus strand

Genomic View for RIOK2 Gene

Genes around RIOK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIOK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK2 Gene

Proteins for RIOK2 Gene

  • Protein details for RIOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase RIO2
    Protein Accession:
    Secondary Accessions:
    • D6RDI3
    • Q9NUT0

    Protein attributes for RIOK2 Gene

    552 amino acids
    Molecular mass:
    63283 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RIOK2 Gene

    Alternative splice isoforms for RIOK2 Gene


neXtProt entry for RIOK2 Gene

Proteomics data for RIOK2 Gene at MOPED

Post-translational modifications for RIOK2 Gene

  • Ubiquitination at Lys 86 and Lys 288
  • Modification sites at PhosphoSitePlus

Other Protein References for RIOK2 Gene

No data available for DME Specific Peptides for RIOK2 Gene

Domains & Families for RIOK2 Gene

Gene Families for RIOK2 Gene

Protein Domains for RIOK2 Gene

Suggested Antigen Peptide Sequences for RIOK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
genes like me logo Genes that share domains with RIOK2: view

Function for RIOK2 Gene

Molecular function for RIOK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for RIOK2 Gene

Gene Ontology (GO) - Molecular Function for RIOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RIOK2: view
genes like me logo Genes that share phenotypes with RIOK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RIOK2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIOK2 Gene

Localization for RIOK2 Gene

Subcellular locations from

Jensen Localization Image for RIOK2 Gene COMPARTMENTS Subcellular localization image for RIOK2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIOK2 Gene

Pathways & Interactions for RIOK2 Gene

genes like me logo Genes that share pathways with RIOK2: view

Pathways by source for RIOK2 Gene

Gene Ontology (GO) - Biological Process for RIOK2 Gene


No data available for SIGNOR curated interactions for RIOK2 Gene

Drugs & Compounds for RIOK2 Gene

(1) Drugs for RIOK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for RIOK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with RIOK2: view

Transcripts for RIOK2 Gene

Unigene Clusters for RIOK2 Gene

RIO kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -

Relevant External Links for RIOK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIOK2 Gene

mRNA expression in normal human tissues for RIOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RIOK2 Gene

This gene is overexpressed in Adrenal (32.0), Lung (14.8), Breast (10.2), and Pancreas (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIOK2 Gene

SOURCE GeneReport for Unigene cluster for RIOK2 Gene Hs.27021

genes like me logo Genes that share expression patterns with RIOK2: view

Protein tissue co-expression partners for RIOK2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIOK2 Gene

Orthologs for RIOK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIOK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RIOK2 35
  • 88.14 (n)
  • 87.11 (a)
RIOK2 36
  • 87 (a)
(Canis familiaris)
Mammalia RIOK2 35
  • 88.14 (n)
  • 85.4 (a)
RIOK2 36
  • 85 (a)
(Mus musculus)
Mammalia Riok2 35
  • 83.24 (n)
  • 83.73 (a)
Riok2 16
Riok2 36
  • 84 (a)
(Pan troglodytes)
Mammalia RIOK2 35
  • 99.15 (n)
  • 99.09 (a)
RIOK2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Riok2 35
  • 82.64 (n)
  • 81.85 (a)
(Monodelphis domestica)
Mammalia RIOK2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
-- 36
  • 70 (a)
(Gallus gallus)
Aves RIOK2 35
  • 70.62 (n)
  • 69.94 (a)
RIOK2 36
  • 66 (a)
(Anolis carolinensis)
Reptilia RIOK2 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia riok2 35
  • 67.66 (n)
  • 68.83 (a)
Str.2960 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1664 35
(Danio rerio)
Actinopterygii Dr.24247 35
riok2 35
  • 68.21 (n)
  • 74.45 (a)
riok2 36
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001526 35
  • 51.32 (n)
  • 47.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11859 35
  • 52.24 (n)
  • 49.51 (a)
CG11859 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea riok-2 35
  • 58.97 (n)
  • 59.62 (a)
riok-2 36
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL166W 35
  • 51.78 (n)
  • 44.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19008g 35
  • 52.09 (n)
  • 45.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO2 35
  • 52.59 (n)
  • 45.83 (a)
RIO2 36
  • 39 (a)
RIO2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51270 35
  • 58.04 (n)
  • 58.58 (a)
(Hordeum vulgare)
Liliopsida Hv.1543 35
(Oryza sativa)
Liliopsida Os.14437 35
Os01g0888700 35
  • 59.61 (n)
  • 58.96 (a)
(Zea mays)
Liliopsida Zm.5985 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07722 35
  • 53.92 (n)
  • 56.84 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1703.05 35
  • 58.74 (n)
  • 54.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for RIOK2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK2 Gene

Gene Tree for RIOK2 (if available)
Gene Tree for RIOK2 (if available)

Paralogs for RIOK2 Gene Pseudogenes for RIOK2 Gene

genes like me logo Genes that share paralogs with RIOK2: view

No data available for Paralogs for RIOK2 Gene

Variants for RIOK2 Gene

Sequence variations from dbSNP and Humsavar for RIOK2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_031597 -
VAR_031598 -
VAR_031599 -
VAR_042347 -
VAR_042348 -

Structural Variations from Database of Genomic Variants (DGV) for RIOK2 Gene

Variant ID Type Subtype PubMed ID
nsv830412 CNV Loss 17160897
nsv830413 CNV Loss 17160897
dgv6220n71 CNV Gain 21882294
nsv882393 CNV Gain 21882294
esv1385283 CNV Insertion 17803354

Variation tolerance for RIOK2 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.71; 93.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RIOK2 Gene

Disorders for RIOK2 Gene

Relevant External Links for RIOK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RIOK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIOK2 Gene

Publications for RIOK2 Gene

  1. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PMID: 19578876) Johnson M.P. … Moses E.K. (Hum. Genet. 2009) 3 48 67
  2. Discovery of selective RIO2 kinase small molecule ligand. (PMID: 25891899) Varin T. … Vieth M. (Biochim. Biophys. Acta 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for RIOK2 Gene

Sources for RIOK2 Gene