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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RIOK2 Gene

protein-coding GIFtS: 53
GCID: GC05M096496

RIO kinase 2

(Previous name: RIO kinase 2 (yeast) )

Explore 4 diseases affiliated with
RIOK2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RIO Kinase 2¹ ² ³
FLJ11159¹
RIO Kinase 2 (Yeast)¹
RIO2²
Serine/Threonine-Protein Kinase RIO2²
EC 2.7.11.1³

External Ids:	HGNC: 18999¹	Entrez Gene: 55781²	Ensembl: ENSG00000058729⁷	UniProtKB: Q9BVS4³

Export aliases for RIOK2 gene to outside databases

Previous GC identifers: GC05M096525 GC05M096572 GC05M096570 GC05M096524 GC05M091686

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RIOK2 gene promoter:
CUTL1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 GATA-1 POU2F1 POU2F1b FOXO4 POU2F1a POU2F1c
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RIOK2 promoter sequence

Search SABiosciences Chromatin IP Primers for RIOK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIOK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15 Ensembl cytogenetic band: 5q15 HGNC cytogenetic band: 5q14

RIOK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIOK2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M096496: view genomic region (about GC identifiers)

Start:	96,496,571 bp from pter	End:	96,519,005 bp from pter
Size:	22,435 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RIOK2_HUMAN, Q9BVS4 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase RIO2

Size: 552 amino acids; 63283 Da

Secondary accessions: Q9NUT0

Explore the universe of human proteins at neXtProt for RIOK2: NX_Q9BVS4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BVS4

RIOK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001153221.1 NP_060813.2

ENSEMBL proteins:

ENSP00000283109 ENSP00000421830 ENSP00000422772 ENSP00000420932 ENSP00000424325

Human Recombinant Protein Products:

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	Uscn Proteins for RIOK2

RIOK2 Antibody Products:

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	Uscn ELISAs and CLIAs for RIOK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RIOK2 for domains About GeneDecksing

5 InterPro domains/families:

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR018934 RIO-like_kinase

IPR011009 Kinase-like_dom

IPR018935 RIO_kinase_CS

IPR015285 RIO2_kinase_winged_hlx_N

Graphical View of Domain Structure for InterPro Entry Q9BVS4

ProtoNet protein and cluster: Q9BVS4

1 Blocks protein family: IPB000687 Protein of unknown function RIO1

UniProtKB/Swiss-Prot: RIOK2_HUMAN, Q9BVS4

Similarity: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RIOK2_HUMAN, Q9BVS4

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RIOK2 Browse MicroRNA Expression Plasmids
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		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RIOK2:
		hsa-miR-579 hsa-miR-182* hsa-miR-3924
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIOK2 (see all 7) OriGene shRNA RFP: RIOK2 OriGene siRNA: RIOK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIOK2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RIOK2

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIOK2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIOK2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RIOK2 (NM_018343)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RIOK2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIOK2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--

RIOK2 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for RIOK2:

Cytoplasmic 40S maturation def	Increased cell death HMECs cel	Increased cell death in breast	Increased homologous recombina
Stronger migration

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ribosome biogenesis in eukaryotes

Ribosome biogenesis in eukaryotes

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for RIOK2):

Ribosome biogenesis in eukaryotes

RIOK2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RIOK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/135 Interacting proteins for RIOK2 (Q9BVS4³ ENSP00000283109⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 135)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RIOK2

2 HMDB Compounds for RIOK2 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Search CenterWatch for drugs/clinical trials and news about RIOK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RIOK2 gene (2 alternative transcripts):

NM_001159749.1 NM_018343.2

Unigene Cluster for RIOK2:

RIO kinase 2

Hs.27021 [show with all ESTs]

Unigene Representative Sequence: NM_018343

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000283109(uc003kmz.3) ENST00000511293 ENST00000511012 ENST00000508447(uc003kna.3)

ENST00000508991 ENST00000511920 ENST00000510384

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RIOK2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIOK2
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RIOK2:
		hsa-miR-579 hsa-miR-182* hsa-miR-3924
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIOK2 (see all 7) OriGene shRNA RFP: RIOK2 OriGene siRNA: RIOK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIOK2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIOK2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIOK2 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RIOK2 (NM_018343)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIOK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIOK2

Additional cDNA sequence:

AK001697.1 AK002021.1 AK225348.1 BC000953.2

7 DOTS entries:

DT.111452 DT.100651609 DT.91689773 DT.100742598 DT.120869613 DT.120869711 DT.95163648

24/135 AceView cDNA sequences (see all 135):

BI819237 CA425714 Z42096 BM554462 BC000953 BM677568 CR622281 BX110904

BP365447 AI566080 BQ049234 BM759119 Z38366 N51083 BU784325 CN485193

CR610601 CA448205 AL557488 AL602975 BM503406 AI350582 AK002021 BE889273

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for RIOK2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10
SP1:			-
SP2:

ECgene alternative splicing isoforms for RIOK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RIOK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RIOK2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Reproductive System

Mesonephros

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RIOK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIOK2

SOURCE GeneReport for Unigene cluster: Hs.27021

SABiosciences Custom PCR Arrays for RIOK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIOK2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIOK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIOK2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIOK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIOK2 gene from 10/37 species (see all 37) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Riok2^{1 , 5}	RIO kinase 2 (yeast)^{1, 5}	83.24(n)¹ 83.73(a)¹		17 (9.77 cM)⁵ 67045¹ NM_025934.2¹ NP_080210.1¹ 17374332⁵
chicken (Gallus gallus)	Aves	RIOK2¹	RIO kinase 2 (yeast)	70.62(n) 69.94(a)		427278 NM_001006581.2 NP_001006581.2
lizard (Anolis carolinensis)	Reptilia	RIOK2⁶	--	85(a)	1 ↔ 1	2(26700897-26711210)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1664²	Xenopus laevis transcribed sequence with moderate similarity more	78.97(n)		CA790405.1
zebrafish (Danio rerio)	Actinopterygii	Dr.24247²	Danio rerio mRNA similar to hypothetical protein FLJ11159 more	74.97(n)		BC047169.1
fruit fly (Drosophila melanogaster)	Insecta	CG11859¹	CG11859	51.64(n) 47.98(a)		43046 NM_143108.2 NP_651365.1
worm (Caenorhabditis elegans)	Secernentea	riok-2¹	Protein RIOK-2	51.46(n) 45.63(a)		173322 NM_061143.4 NP_493544.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RIO2(YNL207W)⁴ RIO2¹	Essential serine kinase involved in the processing more⁴ Rio2p¹	51.68(n)¹ 45.24(a)¹		14(255353-256630)⁴ 855514^{1, 4} NP_014192.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G51270¹	RIO kinase 2	54.46(n) 52.02(a)		824290 NM_114986.2 NP_190695.2
rice (Oryza sativa)	Liliopsida	Os.14437²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.81(n)		AK119166.1

ENSEMBL Gene Tree for RIOK2 (if available)
TreeFam Gene Tree for RIOK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RIOK2 gene

RIOK2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RIOK2
PGOHUM00000243977

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183409274^1,2		--	96496083(+)	`CATGGC/TTTTTC`	1	--	int¹		0	--	--	--	--
rs30999^1,2	C,F,A,	--	96496150(+)	`TAAACT/GAAAGC`	1	--	int¹		9		MN NA WA EA	688
rs30998^1,2	C,F,A,H,	--	96496189(+)	`TCTCTA/CGGGAG`	1	--	int¹		27		MN NS EA NA WA	3366
rs185760306^1,2		--	96496231(+)	`ATGGCC/GAACTG`	1	--	int¹		0	--	--	--	--
rs147659872^1,2		--	96496250(+)	`CCAGAA/GTGCTG`	1	--	int¹		0	--	--	--	--
rs115244283^1,2		--	96496362(+)	`TCAGGC/AAGAGT`	1	--	int¹		1		WA	118
rs30997^1,2	C,F,A,H,	--	96496389(+)	`TATGTA/GTTTTG`	1	--	int¹		19		NS EA WA CSA NA	2336
rs144955121^1,2		--	96496421(+)	`TGGCTA/GAAAGA`	1	--	int¹		0	--	--	--	--
rs17629822^1,2	C,F,H,	--	96496437(+)	`TATCTC/TGAGCT`	1	--	int¹		18		NA NS EA	1842
rs112189843^1,2	C,F,	--	96496471(+)	`TTAAAC/TATCTA`	1	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for RIOK2 (96496571 - 96519005 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RIOK2
1 CNV: 4467

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIOK2

DNA2.0 Custom Variant and Variant Library Synthesis for RIOK2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RIOK2 for disorders About GeneDecksing

4 diseases for RIOK2: About MalaCards

diamond-blackfan anemia anemia malaria alcoholism

1 disease from the University of Copenhagen DISEASES database for RIOK2:

Diamond-Blackfan anemia

Human Genome Epidemiology (HuGE) Navigator: RIOK2 (3 documents)

Export disorders for RIOK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RIOK2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with RIOK2)

Utopia: connect your pdf to the dynamic
world of online information

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression. (PubMed id 21880710)¹ Liu T....Ye X. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55781	HGNC: 18999	AceView: RIOK2	Ensembl:ENSG00000058729	euGenes: HUgn55781
ECgene: RIOK2	Kegg: 55781	H-InvDB: RIOK2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RIOK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RIOK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RIOK2 gene:
Search GeneIP for patents involving RIOK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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RIO kinase 2

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for RIOK2 gene

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Intellectual Property
for RIOK2 gene

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