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Aliases for RIOK2 Gene

Aliases for RIOK2 Gene

  • RIO Kinase 2 2 3 4 5
  • Serine/Threonine-Protein Kinase RIO2 3
  • RIO Kinase 2 (Yeast) 2
  • EC 2.7.11.1 4
  • RIO2 3

External Ids for RIOK2 Gene

Previous GeneCards Identifiers for RIOK2 Gene

  • GC05M096525
  • GC05M096572
  • GC05M096570
  • GC05M096524
  • GC05M096496
  • GC05M091686

Summaries for RIOK2 Gene

GeneCards Summary for RIOK2 Gene

RIOK2 (RIO Kinase 2) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK2 Gene

Genomics for RIOK2 Gene

Regulatory Elements for RIOK2 Gene

Enhancers for RIOK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F096699 1.4 Ensembl ENCODE 45.6 +478.3 478291 11.6 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF548 ENSG00000248734 RIOK2 ERAP1 CAST ENSG00000249180 HSPD1P11 LOC101929710
GH05F096219 1.5 FANTOM5 ENCODE 27.8 +962.7 962657 2.8 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RIOK2 PCSK1 ENSG00000249746 ENSG00000250158
GH05F097181 1.1 ENCODE 32.6 +0.2 187 2.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 RIOK2 ENSG00000248202 GC05M097176 RNU1-73P
GH05F096932 1.2 ENCODE 23.2 +248.7 248684 6.6 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ERAP2 RIOK2 ERAP1 ENSG00000251054 ENSG00000250955 LOC391813 ENSG00000248734 LNPEP
GH05F096626 1.4 Ensembl ENCODE 18.1 +554.8 554777 5.0 PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ERAP1 ENSG00000248734 RIOK2 LOC101929710 CAST ERAP2 ENSG00000249180
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIOK2 on UCSC Golden Path with GeneCards custom track

Promoters for RIOK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001286066 301 2800 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for RIOK2 Gene

Chromosome:
5
Start:
97,160,867 bp from pter
End:
97,183,301 bp from pter
Size:
22,435 bases
Orientation:
Minus strand

Genomic View for RIOK2 Gene

Genes around RIOK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIOK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK2 Gene

Proteins for RIOK2 Gene

  • Protein details for RIOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVS4-RIOK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase RIO2
    Protein Accession:
    Q9BVS4
    Secondary Accessions:
    • D6RDI3
    • Q9NUT0

    Protein attributes for RIOK2 Gene

    Size:
    552 amino acids
    Molecular mass:
    63283 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RIOK2 Gene

    Alternative splice isoforms for RIOK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIOK2 Gene

Post-translational modifications for RIOK2 Gene

  • Ubiquitination at Lys 86 and Lys 288
  • Modification sites at PhosphoSitePlus

Other Protein References for RIOK2 Gene

No data available for DME Specific Peptides for RIOK2 Gene

Domains & Families for RIOK2 Gene

Gene Families for RIOK2 Gene

Suggested Antigen Peptide Sequences for RIOK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVS4

UniProtKB/Swiss-Prot:

RIOK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
genes like me logo Genes that share domains with RIOK2: view

Function for RIOK2 Gene

Molecular function for RIOK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for RIOK2 Gene

Gene Ontology (GO) - Molecular Function for RIOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with RIOK2: view
genes like me logo Genes that share phenotypes with RIOK2: view

Animal Models for RIOK2 Gene

MGI Knock Outs for RIOK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for RIOK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RIOK2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIOK2 Gene

Localization for RIOK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIOK2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RIOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RIOK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RIOK2 Gene

Pathways & Interactions for RIOK2 Gene

genes like me logo Genes that share pathways with RIOK2: view

Gene Ontology (GO) - Biological Process for RIOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with RIOK2: view

No data available for SIGNOR curated interactions for RIOK2 Gene

Drugs & Compounds for RIOK2 Gene

(1) Drugs for RIOK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for RIOK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with RIOK2: view

Transcripts for RIOK2 Gene

Unigene Clusters for RIOK2 Gene

RIO kinase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RIOK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2:

Relevant External Links for RIOK2 Gene

GeneLoc Exon Structure for
RIOK2
ECgene alternative splicing isoforms for
RIOK2

Expression for RIOK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RIOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RIOK2 Gene

This gene is overexpressed in Adrenal (32.0), Lung (14.8), Breast (10.2), and Pancreas (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIOK2 Gene



Protein tissue co-expression partners for RIOK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIOK2 Gene:

RIOK2

SOURCE GeneReport for Unigene cluster for RIOK2 Gene:

Hs.27021
genes like me logo Genes that share expression patterns with RIOK2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIOK2 Gene

Orthologs for RIOK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIOK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIOK2 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia RIOK2 34 35
  • 88.14 (n)
dog
(Canis familiaris)
Mammalia RIOK2 34 35
  • 88.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Riok2 34 16 35
  • 83.24 (n)
rat
(Rattus norvegicus)
Mammalia Riok2 34
  • 82.64 (n)
oppossum
(Monodelphis domestica)
Mammalia RIOK2 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIOK2 34 35
  • 70.62 (n)
lizard
(Anolis carolinensis)
Reptilia RIOK2 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia riok2 34
  • 67.66 (n)
Str.2960 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1664 34
zebrafish
(Danio rerio)
Actinopterygii riok2 34 35
  • 68.21 (n)
Dr.24247 34
fruit fly
(Drosophila melanogaster)
Insecta CG11859 34 35
  • 52.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001526 34
  • 51.32 (n)
worm
(Caenorhabditis elegans)
Secernentea riok-2 34 35
  • 58.97 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO2 34 35 37
  • 52.59 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19008g 34
  • 52.09 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL166W 34
  • 51.78 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51270 34
  • 58.04 (n)
rice
(Oryza sativa)
Liliopsida Os01g0888700 34
  • 59.61 (n)
Os.14437 34
barley
(Hordeum vulgare)
Liliopsida Hv.1543 34
corn
(Zea mays)
Liliopsida Zm.5985 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1703.05 34
  • 58.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU07722 34
  • 53.92 (n)
Species where no ortholog for RIOK2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK2 Gene

ENSEMBL:
Gene Tree for RIOK2 (if available)
TreeFam:
Gene Tree for RIOK2 (if available)

Paralogs for RIOK2 Gene

Pseudogenes.org Pseudogenes for RIOK2 Gene

genes like me logo Genes that share paralogs with RIOK2: view

No data available for Paralogs for RIOK2 Gene

Variants for RIOK2 Gene

Sequence variations from dbSNP and Humsavar for RIOK2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs147608663 A renal clear cell carcinoma sample 97,171,338(+) TGACA(A/G)TTAGT intron-variant, reference, missense
rs10035897 -- 97,179,978(+) atata(A/T)tatat intron-variant
rs10036496 -- 97,179,979(+) tataa(A/T)atata intron-variant
rs10036499 -- 97,180,004(+) atata(A/T)tatat intron-variant
rs10037862 -- 97,163,159(+) CTGCA(A/G)TCGAC intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RIOK2 Gene

Variant ID Type Subtype PubMed ID
nsv830413 CNV loss 17160897
nsv830412 CNV loss 17160897
nsv598962 CNV gain 21841781
nsv1144114 CNV deletion 24896259
nsv1021263 CNV loss 25217958
esv3890674 CNV gain 25118596
esv3605874 CNV gain 21293372
esv3605872 CNV gain 21293372
esv1385283 CNV insertion 17803354

Variation tolerance for RIOK2 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.71; 93.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIOK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIOK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOK2 Gene

Disorders for RIOK2 Gene

Relevant External Links for RIOK2

Genetic Association Database (GAD)
RIOK2
Human Genome Epidemiology (HuGE) Navigator
RIOK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIOK2

No disorders were found for RIOK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIOK2 Gene

Publications for RIOK2 Gene

  1. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. (PMID: 19578876) Johnson M.P. … Moses E.K. (Hum. Genet. 2009) 3 46 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for RIOK2 Gene

Sources for RIOK2 Gene

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