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Aliases for RIOK1 Gene

Aliases for RIOK1 Gene

  • RIO Kinase 1 2 3 4
  • Serine/Threonine-Protein Kinase RIO1 3
  • RIO Kinase 1 (Yeast) 2
  • EC 2.7.11.1 4
  • BA288G3.1 3
  • AD034 3
  • RRP10 3

External Ids for RIOK1 Gene

Summaries for RIOK1 Gene

Entrez Gene Summary for RIOK1 Gene

  • This gene includes two alternatively spliced transcript variants, which encode different isoforms. The function of this gene has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIOK1 Gene

RIOK1 (RIO Kinase 1) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is RIOK3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK1 Gene

Genomics for RIOK1 Gene

Genomic Location for RIOK1 Gene

Start:
7,389,496 bp from pter
End:
7,418,037 bp from pter
Size:
28,542 bases
Orientation:
Plus strand

Genomic View for RIOK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIOK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK1 Gene

Regulatory Elements for RIOK1 Gene

Proteins for RIOK1 Gene

  • Protein details for RIOK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRS2-RIOK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase RIO1
    Protein Accession:
    Q9BRS2
    Secondary Accessions:
    • B2RB28
    • Q8NDC8
    • Q96NV9

    Protein attributes for RIOK1 Gene

    Size:
    568 amino acids
    Molecular mass:
    65583 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RIOK1 Gene

neXtProt entry for RIOK1 Gene

Proteomics data for RIOK1 Gene at MOPED

Post-translational modifications for RIOK1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys81

Other Protein References for RIOK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIOK1 Gene

Domains for RIOK1 Gene

Gene Families for RIOK1 Gene

UniProtKB/Swiss-Prot:

RIOK1_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9BRS2
Family:
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.:
    • Q9BRS2
genes like me logo Genes that share domains with RIOK1: view

Function for RIOK1 Gene

Molecular function for RIOK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for RIOK1 Gene

Gene Ontology (GO) - Molecular Function for RIOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with RIOK1: view
genes like me logo Genes that share phenotypes with RIOK1: view

miRNA for RIOK1 Gene

miRTarBase miRNAs that target RIOK1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RIOK1 Gene

Localization for RIOK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIOK1 Gene COMPARTMENTS Subcellular localization image for RIOK1 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for RIOK1 Gene

Pathways for RIOK1 Gene

genes like me logo Genes that share pathways with RIOK1: view

Pathways by source for RIOK1 Gene

1 KEGG pathway for RIOK1 Gene

Gene Ontology (GO) - Biological Process for RIOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with RIOK1: view

Compounds for RIOK1 Gene

(2) HMDB Compounds for RIOK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with RIOK1: view

Transcripts for RIOK1 Gene

Unigene Clusters for RIOK1 Gene

RIO kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for RIOK1 Gene

GeneLoc Exon Structure for
RIOK1
ECgene alternative splicing isoforms for
RIOK1

Expression for RIOK1 Gene

mRNA expression in normal human tissues for RIOK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIOK1 Gene

SOURCE GeneReport for Unigene cluster for RIOK1 Gene Hs.437474

genes like me logo Genes that share expressions with RIOK1: view

Orthologs for RIOK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIOK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIOK1 36
  • 99.24 (n)
  • 98.77 (a)
RIOK1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RIOK1 36
  • 85.8 (n)
  • 88.73 (a)
RIOK1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIOK1 36
  • 89.44 (n)
  • 89.08 (a)
RIOK1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Riok1 36
  • 82.53 (n)
  • 80.5 (a)
Riok1 16
Riok1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RIOK1 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIOK1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Riok1 36
  • 83.3 (n)
  • 81.57 (a)
chicken
(Gallus gallus)
Aves RIOK1 36
  • 75.73 (n)
  • 77.26 (a)
RIOK1 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIOK1 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16329 36
tropical clawed frog
(Silurana tropicalis)
Amphibia riok1 36
  • 73.81 (n)
  • 78.76 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.3368 36
riok1 36
  • 66.85 (n)
  • 71.4 (a)
riok1 37
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012121 36
  • 55.73 (n)
  • 56.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11660 36
  • 53.95 (n)
  • 55.82 (a)
CG11660 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea riok-1 36
  • 58.2 (n)
  • 57.84 (a)
riok-1 37
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER257W 36
  • 51.76 (n)
  • 45.18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO1 36
  • 54.36 (n)
  • 47.68 (a)
RIO1 37
  • 37 (a)
OneToMany
RIO1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21121g 36
  • 52.6 (n)
  • 44.5 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G37350 36
  • 55.58 (n)
  • 53.22 (a)
rice
(Oryza sativa)
Liliopsida Os.17949 36
Os07g0162300 36
  • 54.25 (n)
  • 49.46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10652 36
  • 52.1 (n)
  • 50.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.10 36
  • 55.33 (n)
  • 52.28 (a)
Species with no ortholog for RIOK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK1 Gene

ENSEMBL:
Gene Tree for RIOK1 (if available)
TreeFam:
Gene Tree for RIOK1 (if available)

Paralogs for RIOK1 Gene

Paralogs for RIOK1 Gene

Selected SIMAP similar genes for RIOK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIOK1: view

Variants for RIOK1 Gene

Sequence variations from dbSNP and Humsavar for RIOK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs767243 -- 7,414,076(-) CATCA(G/T)GAGGG intron-variant
rs882457 -- 7,412,664(+) aaaaa(A/C)aaCAA intron-variant
rs1324500 -- 7,392,836(+) AACTT(C/T)AACAA intron-variant
rs2245533 -- 7,414,149(+) TAAAA(C/T)CTGAA intron-variant
rs2274212 -- 7,393,219(+) TATGA(C/T)GATGA reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RIOK1 Gene

Variant ID Type Subtype PubMed ID
nsv462623 CNV Gain 19166990
nsv470797 CNV Gain 18288195
nsv883433 CNV Gain 21882294

Relevant External Links for RIOK1 Gene

HapMap Linkage Disequilibrium report
RIOK1

Disorders for RIOK1 Gene

Relevant External Links for RIOK1

Genetic Association Database (GAD)
RIOK1
genes like me logo Genes that share disorders with RIOK1: view

No data available for UniProtKB/Swiss-Prot for RIOK1 Gene

Publications for RIOK1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PMID: 15324660) Jin J. … Pawson T. (Curr. Biol. 2004) 3
  4. Characterisation of tumour-associated antigens in colon cancer. (PMID: 12384809) Line A. … Rees R.C. (Cancer Immunol. Immunother. 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RIOK1 Gene

  • Addgene plasmids for RIOK1

Sources for RIOK1 Gene

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