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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIOK1 Gene

protein-coding   GIFtS: 57
GCID: GC06P007335

RIO Kinase 1

(Previous name: RIO kinase 1 (yeast))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RIO Kinase 11 2 3     bA288G3.12
RIO Kinase 1 (Yeast)1     Serine/Threonine-Protein Kinase RIO12
AD0342     EC 2.7.11.13
RRP102     

External Ids:    HGNC: 186561   Entrez Gene: 837322   Ensembl: ENSG000001247847   UniProtKB: Q9BRS23   

Export aliases for RIOK1 gene to outside databases

Previous GC identifers: GC06P007380 GC06P007267


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIOK1 Gene:
This gene includes two alternatively spliced transcript variants, which encode different isoforms. The function of
this gene has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for RIOK1 Gene: 
RIOK1 (RIO kinase 1) is a protein-coding gene. Diseases associated with RIOK1 include colon cancer. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is RIOK3.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIOK1 gene promoter:
         AREB6   AML1a   Pbx1a   HTF   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Meis-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIOK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIOK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIOK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.3   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p24.3

RIOK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIOK1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P007335:  view genomic region     (about GC identifiers)

Start:
7,389,729 bp from pter      End:
7,418,270 bp from pter
Size:
28,542 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIOK1_HUMAN, Q9BRS2 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase RIO1  
Size: 568 amino acids; 65583 Da
Secondary accessions: B2RB28 Q8NDC8 Q96NV9

Explore the universe of human proteins at neXtProt for RIOK1: NX_Q9BRS2

Explore proteomics data for RIOK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BRS2

  • RIOK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIOK1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_113668.2  NP_694550.1  

    ENSEMBL proteins: 
     ENSP00000369162   ENSP00000418263  

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    Cloud-Clone Corp. CLIAs for RIOK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: RIO kinase 1 (yeast) 
    RIO1 subfamily

    5 InterPro protein domains:
     IPR000687 RIO_kinase
     IPR011009 Kinase-like_dom
     IPR018935 RIO_kinase_CS
     IPR018934 RIO-like_kinase
     IPR017407 Ser/Thr_kinase_Rio1

    Graphical View of Domain Structure for InterPro Entry Q9BRS2

    ProtoNet protein and cluster: Q9BRS2

    1 Blocks protein domain: IPB000687 Protein of unknown function RIO1

    UniProtKB/Swiss-Prot: RIOK1_HUMAN, Q9BRS2
    Similarity: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family
    Similarity: Contains 1 protein kinase domain


    RIOK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIOK1_HUMAN, Q9BRS2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    RIOK1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RIOK1:
     Decreased melanin production  Decreased substrate adherent c  Gemcitabine induced cell-death  Increased cell death HMECs cel 
     Increased cell death in breast  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIOK1 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIOK1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate RIOK1:
    hsa-miR-2115 hsa-miR-520d-5p hsa-miR-519e hsa-miR-524-5p hsa-miR-515-3p hsa-miR-548c-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidRIOK1 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of RIOK1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIOK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RIOK1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for RIOK1):
        Ribosome biogenesis in eukaryotes


    RIOK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIOK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/620 Interacting proteins for RIOK1 (Q9BRS22, 3 ENSP000003691624) via UniProtKB, MINT, STRING, and/or I2D (see all 620)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50970 I2D: score=3 STRING: ENSP00000300161
    TCP1P179872, 3MINT-7945693 I2D: score=2 
    EIF2S3P410912, 3MINT-7945693 I2D: score=1 
    SMARCD1Q96GM52, 3MINT-7945693 I2D: score=1 
    POLR1CO151602, 3, ENSP000003614654MINT-7945693 I2D: score=1 STRING: ENSP00000361465
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    RIOK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIOK1

    2 HMDB Compounds for RIOK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about RIOK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIOK1 gene (2 alternative transcripts): 
    NM_031480.2  NM_153005.1  

    Unigene Cluster for RIOK1:

    RIO kinase 1
    Hs.437474  [show with all ESTs]
    Unigene Representative Sequence: BC006104
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379834(uc003mxm.1 uc003mxn.3) ENST00000475351 ENST00000264874(uc003mxo.3)
    ENST00000484626 ENST00000493691
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate RIOK1:
    hsa-miR-2115 hsa-miR-520d-5p hsa-miR-519e hsa-miR-524-5p hsa-miR-515-3p hsa-miR-548c-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidRIOK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RIOK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIOK1
    Clone
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    OriGene clones in human, mouse for RIOK1 (see all 11)
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    GenScript: all cDNA clones in your preferred vector (see all 2): RIOK1 (NM_031480)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIOK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIOK1
    Sirion Biotech Customized lentivirus for stable overexpression of RIOK1 
                         Customized lentivirus expression plasmids for stable overexpression of RIOK1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RIOK1
    OriGene qSTAR qPCR primer pairs in human, mouse for RIOK1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIOK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIOK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIOK1

    Additional mRNA sequence: 

    AF258661.1 AK054568.1 AK314467.1 AL834277.1 AY094356.1 BC000811.2 BC006104.1 

    8 DOTS entries:

    DT.453070  DT.97792636  DT.100790350  DT.100790345  DT.100677071  DT.75176060  DT.91750643  DT.100790351 

    24/140 AceView cDNA sequences (see all 140):

    AL834277 BC006104 BQ448589 AI688686 BG644304 AI962832 BM669627 AK054568 
    BI858190 AI688697 AF258661 BC000811 BQ006873 AA702832 NM_031480 CB135500 
    NM_153005 BM987716 CR608910 BE218823 CA437568 CB048066 BF475632 AV708511 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RIOK1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:              -                                                     -                       -                                       
    SP2:                                                                    -                       -                                       
    SP3:                                                                    -                                                               
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for RIOK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIOK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGCCCCAA
    RIOK1 Expression
    About this image


    See RIOK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIOK1

    SOURCE GeneReport for Unigene cluster: Hs.437474
        SABiosciences Custom PCR Arrays for RIOK1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIOK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RIOK1 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Riok11 , 5 RIO kinase 1 (yeast)1, 5 83.01(n)1
    81.22(a)1
      13 (17.91 cM)5
    713401  NM_024242.31  NP_077204.21 
     380369895 
    chicken
    (Gallus gallus)
    Aves RIOK11 RIO kinase 1 (yeast) 75.34(n)
    76.81(a)
      420870  XM_418958.3  XP_418958.2 
    lizard
    (Anolis carolinensis)
    Reptilia RIOK16
    RIO kinase 1
    75(a)
    1 ↔ 1
    GL343311.1(481028-506700)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163292 Xenopus laevis transcribed sequence with weak similarity more 76.01(n)    CA788872.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.33682 Danio rerio mRNA similar to AD034 protein (cDNA clone more 76.55(n)    BC045984.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116601 CG11660 53.91(n)
    54.03(a)
      39309  NM_140232.2  NP_648489.1 
    worm
    (Caenorhabditis elegans)
    Secernentea riok-11 Protein RIOK-1 53.33(n)
    48.33(a)
      171883  NM_001026399.6  NP_001021570.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RIO1(YOR119C)4
    RIO11
    Essential serine kinase involved in cell cycle progression more4
    Rio1p1
    53.41(n)1
    45.95(a)1
      15(550246-548792)4
    8542861, 4  NP_014762.31  NP_014762.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G249901 RIO kinase 1 55.08(n)
    50.81(a)
      817038  NM_128057.2  NP_180071.1 
    rice
    (Oryza sativa)
    Liliopsida Os.179492 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.31(n)    NM_186417.1 


    ENSEMBL Gene Tree for RIOK1 (if available)
    TreeFam Gene Tree for RIOK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIOK1 gene
    RIOK32  
    1 SIMAP similar gene for RIOK1 using alignment to 2 protein entries:     RIOK1_HUMAN (see all proteins):
    RIOK3

    RIOK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/597 SNPs in RIOK1 are shown (see all 597)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891733871,2
    --7329628(+) AATACG/TATTTA 1 -- us2k10--------
    rs95051941,2
    H--7391952(+) CATTAG/ATGGCA 1 -- int15Minor allele frequency- A:0.00NS EA NA 422
    rs49594331,2
    C,F,A--7392008(+) GCAGAA/GGACAG 1 -- int19Minor allele frequency- G:0.37NA WA CSA EA 370
    rs93284191,2
    C,F,A,H--7392115(+) GGTAAG/ATAGCA 1 -- int121Minor allele frequency- A:0.37NS EA NA CSA WA 1036
    rs1837910641,2
    --7392150(+) TTCCTC/GCACAT 1 -- int10--------
    rs1879287811,2
    --7392190(+) AATTAA/GTAAAT 1 -- int10--------
    rs799653331,2
    C,F--7392314(+) GAGTCC/GTCTGT 1 -- int11Minor allele frequency- G:0.09WA 118
    rs93921561,2
    H--7392467(+) gaattC/Ttaata 1 -- int14Minor allele frequency- T:0.00NS EA 418
    rs355703271,2
    C--7392477(+) AAAAA-/A/AA  
            
    GCCCT
    1 -- int11NA 2
    rs1406397071,2
    C--7392477(+) ATGGC-/AAAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RIOK1 (7389729 - 7418270 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RIOK1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883433CNV Gain21882294
    nsv462623CNV Gain19166990
    nsv470797CNV Gain18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RIOK1:    About MalaCards
    colon cancer    


    RIOK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RIOK1

    Export disorders for RIOK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIOK1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with RIOK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A kinome-wide RNAi screen in Drosophila Glia reveals t hat the RIO kinases mediate cell proliferation and survival through TORC2-Akt si gnaling in glioblastoma. (PubMed id 23459592)1 Read R.D....Thomas J.B. (2013)
    4. Deubiquitinase FAM/USP9X interacts with the E3 ubiquit in ligase SMURF1 protein and protects it from ligase activity-dependent self-deg radation. (PubMed id 23184937)1 Xie Y....Cong F. (2013)
    5. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)
    6. SGTA recognizes a noncanonical ubiquitin-like domain i n the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degra dation. (PubMed id 23246001)1 Xu Y....Ye Y. (2012)
    7. The kinase activity of human Rio1 is required for fina l steps of cytoplasmic maturation of 40S subunits. (PubMed id 22072790)1 Widmann B....Kutay U. (2012)
    8. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83732 HGNC: 18656 AceView: RIOK1 Ensembl:ENSG00000124784 euGenes: HUgn83732
    ECgene: RIOK1 Kegg: 83732 H-InvDB: RIOK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIOK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIOK1 gene:
    Search GeneIP for patents involving RIOK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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