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Aliases for RIOK1 Gene

Aliases for RIOK1 Gene

  • RIO Kinase 1 2 3 4
  • RIO Kinase 1 (Yeast) 2
  • EC 2.7.11.1 4
  • BA288G3.1 3
  • AD034 3
  • RRP10 3

External Ids for RIOK1 Gene

Previous GeneCards Identifiers for RIOK1 Gene

  • GC06P007380
  • GC06P007335
  • GC06P007267

Summaries for RIOK1 Gene

Entrez Gene Summary for RIOK1 Gene

  • This gene includes two alternatively spliced transcript variants, which encode different isoforms. The function of this gene has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIOK1 Gene

RIOK1 (RIO Kinase 1) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is RIOK3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK1 Gene

Genomics for RIOK1 Gene

Regulatory Elements for RIOK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIOK1 Gene

Chromosome:
6
Start:
7,389,419 bp from pter
End:
7,418,037 bp from pter
Size:
28,619 bases
Orientation:
Plus strand

Genomic View for RIOK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIOK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK1 Gene

Proteins for RIOK1 Gene

  • Protein details for RIOK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRS2-RIOK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase RIO1
    Protein Accession:
    Q9BRS2
    Secondary Accessions:
    • B2RB28
    • Q8NDC8
    • Q96NV9

    Protein attributes for RIOK1 Gene

    Size:
    568 amino acids
    Molecular mass:
    65583 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RIOK1 Gene

neXtProt entry for RIOK1 Gene

Proteomics data for RIOK1 Gene at MOPED

Post-translational modifications for RIOK1 Gene

  • Ubiquitination at Lys 81
  • Modification sites at PhosphoSitePlus

Other Protein References for RIOK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RIOK1 Gene

Domains & Families for RIOK1 Gene

Gene Families for RIOK1 Gene

Protein Domains for RIOK1 Gene

Suggested Antigen Peptide Sequences for RIOK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRS2

UniProtKB/Swiss-Prot:

RIOK1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
genes like me logo Genes that share domains with RIOK1: view

Function for RIOK1 Gene

Molecular function for RIOK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for RIOK1 Gene

Gene Ontology (GO) - Molecular Function for RIOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RIOK1: view
genes like me logo Genes that share phenotypes with RIOK1: view

Animal Model Products

miRNA for RIOK1 Gene

miRTarBase miRNAs that target RIOK1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIOK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RIOK1 Gene

Localization for RIOK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIOK1 Gene COMPARTMENTS Subcellular localization image for RIOK1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIOK1 Gene

Pathways & Interactions for RIOK1 Gene

genes like me logo Genes that share pathways with RIOK1: view

Pathways by source for RIOK1 Gene

1 KEGG pathway for RIOK1 Gene

Gene Ontology (GO) - Biological Process for RIOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with RIOK1: view

No data available for SIGNOR curated interactions for RIOK1 Gene

Drugs & Compounds for RIOK1 Gene

(1) Drugs for RIOK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for RIOK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with RIOK1: view

Transcripts for RIOK1 Gene

Unigene Clusters for RIOK1 Gene

RIO kinase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIOK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5:

Relevant External Links for RIOK1 Gene

GeneLoc Exon Structure for
RIOK1
ECgene alternative splicing isoforms for
RIOK1

Expression for RIOK1 Gene

mRNA expression in normal human tissues for RIOK1 Gene

Protein differential expression in normal tissues from HIPED for RIOK1 Gene

This gene is overexpressed in Monocytes (14.8), Testis (13.8), Liver, secretome (11.8), Lung (9.7), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIOK1 Gene



SOURCE GeneReport for Unigene cluster for RIOK1 Gene Hs.437474

genes like me logo Genes that share expression patterns with RIOK1: view

Protein tissue co-expression partners for RIOK1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIOK1 Gene

Orthologs for RIOK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIOK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RIOK1 35
  • 85.8 (n)
  • 88.73 (a)
RIOK1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIOK1 35
  • 89.44 (n)
  • 89.08 (a)
RIOK1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Riok1 35
  • 82.53 (n)
  • 80.5 (a)
Riok1 16
Riok1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RIOK1 35
  • 99.24 (n)
  • 98.77 (a)
RIOK1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Riok1 35
  • 83.3 (n)
  • 81.57 (a)
oppossum
(Monodelphis domestica)
Mammalia RIOK1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIOK1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIOK1 35
  • 75.73 (n)
  • 77.26 (a)
RIOK1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIOK1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia riok1 35
  • 73.81 (n)
  • 78.76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16329 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3368 35
riok1 35
  • 66.85 (n)
  • 71.4 (a)
riok1 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012121 35
  • 55.73 (n)
  • 56.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11660 35
  • 53.95 (n)
  • 55.82 (a)
CG11660 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea riok-1 35
  • 58.2 (n)
  • 57.84 (a)
riok-1 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER257W 35
  • 51.76 (n)
  • 45.18 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21121g 35
  • 52.6 (n)
  • 44.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO1 35
  • 54.36 (n)
  • 47.68 (a)
RIO1 36
  • 37 (a)
OneToMany
RIO1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G37350 35
  • 55.58 (n)
  • 53.22 (a)
rice
(Oryza sativa)
Liliopsida Os.17949 35
Os07g0162300 35
  • 54.25 (n)
  • 49.46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10652 35
  • 52.1 (n)
  • 50.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.10 35
  • 55.33 (n)
  • 52.28 (a)
Species with no ortholog for RIOK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK1 Gene

ENSEMBL:
Gene Tree for RIOK1 (if available)
TreeFam:
Gene Tree for RIOK1 (if available)

Paralogs for RIOK1 Gene

Paralogs for RIOK1 Gene

(1) SIMAP similar genes for RIOK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIOK1: view

Variants for RIOK1 Gene

Sequence variations from dbSNP and Humsavar for RIOK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs145924365 -- 7,404,718(+) GTCAC(C/T)GAATT intron-variant
rs145654280 untested, untested 7,405,319(+) CCATC(C/T)ATTAC reference, synonymous-codon
rs145488999 -- 7,393,232(+) ATGAT(A/G)ACTGG missense, reference, utr-variant-5-prime
rs145471836 -- 7,416,508(+) CCGGG(C/T)GTGGT intron-variant
rs145260294 -- 7,416,025(+) GGAGT(C/T)TTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIOK1 Gene

Variant ID Type Subtype PubMed ID
nsv462623 CNV Gain 19166990
nsv470797 CNV Gain 18288195
nsv883433 CNV Gain 21882294

Variation tolerance for RIOK1 Gene

Residual Variation Intolerance Score: 70.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIOK1 Gene

HapMap Linkage Disequilibrium report
RIOK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOK1 Gene

Disorders for RIOK1 Gene

Relevant External Links for RIOK1

Genetic Association Database (GAD)
RIOK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIOK1
genes like me logo Genes that share disorders with RIOK1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIOK1 Gene

Publications for RIOK1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67
  4. Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes. (PMID: 24948609) Ferreira-Cerca S. … Hurt E. (Nucleic Acids Res. 2014) 67
  5. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. (PMID: 23459592) Read R.D. … Thomas J.B. (PLoS Genet. 2013) 67

Products for RIOK1 Gene

Sources for RIOK1 Gene

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