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Aliases for RIOK1 Gene

Aliases for RIOK1 Gene

  • RIO Kinase 1 2 3 4
  • Serine/Threonine-Protein Kinase RIO1 3
  • RIO Kinase 1 (Yeast) 2
  • EC 4
  • BA288G3.1 3
  • AD034 3
  • RRP10 3

External Ids for RIOK1 Gene

Previous GeneCards Identifiers for RIOK1 Gene

  • GC06P007380
  • GC06P007335
  • GC06P007267

Summaries for RIOK1 Gene

Entrez Gene Summary for RIOK1 Gene

  • This gene includes two alternatively spliced transcript variants, which encode different isoforms. The function of this gene has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for RIOK1 Gene

RIOK1 (RIO Kinase 1) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is RIOK3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIOK1 Gene

Genomics for RIOK1 Gene

Regulatory Elements for RIOK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIOK1 Gene

7,389,496 bp from pter
7,418,037 bp from pter
28,542 bases
Plus strand

Genomic View for RIOK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIOK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIOK1 Gene

Proteins for RIOK1 Gene

  • Protein details for RIOK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase RIO1
    Protein Accession:
    Secondary Accessions:
    • B2RB28
    • Q8NDC8
    • Q96NV9

    Protein attributes for RIOK1 Gene

    568 amino acids
    Molecular mass:
    65583 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RIOK1 Gene

neXtProt entry for RIOK1 Gene

Proteomics data for RIOK1 Gene at MOPED

Post-translational modifications for RIOK1 Gene

  • Ubiquitination at Lys81
  • Modification sites at PhosphoSitePlus

Other Protein References for RIOK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RIOK1 Gene

Domains for RIOK1 Gene

Gene Families for RIOK1 Gene

Suggested Antigen Peptide Sequences for RIOK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
genes like me logo Genes that share domains with RIOK1: view

Function for RIOK1 Gene

Molecular function for RIOK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for RIOK1 Gene

Gene Ontology (GO) - Molecular Function for RIOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with RIOK1: view
genes like me logo Genes that share phenotypes with RIOK1: view

Animal Model Products

miRNA for RIOK1 Gene

miRTarBase miRNAs that target RIOK1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIOK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RIOK1 Gene

Localization for RIOK1 Gene

Subcellular locations from

Jensen Localization Image for RIOK1 Gene COMPARTMENTS Subcellular localization image for RIOK1 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIOK1 Gene

Pathways for RIOK1 Gene

genes like me logo Genes that share pathways with RIOK1: view

Pathways by source for RIOK1 Gene

1 KEGG pathway for RIOK1 Gene

Gene Ontology (GO) - Biological Process for RIOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with RIOK1: view

Drugs for RIOK1 Gene

(2) HMDB Compounds for RIOK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
genes like me logo Genes that share compounds with RIOK1: view

Transcripts for RIOK1 Gene

Unigene Clusters for RIOK1 Gene

RIO kinase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIOK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIOK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for RIOK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIOK1 Gene

mRNA expression in normal human tissues for RIOK1 Gene

Protein differential expression in normal tissues for RIOK1 Gene

This gene is overexpressed in Monocytes (14.8), Testis (13.8), Liver, secretome (11.8), Lung (9.7), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIOK1 Gene

SOURCE GeneReport for Unigene cluster for RIOK1 Gene Hs.437474

genes like me logo Genes that share expressions with RIOK1: view

Expression partners for RIOK1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIOK1 Gene

Orthologs for RIOK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIOK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RIOK1 35
  • 85.8 (n)
  • 88.73 (a)
RIOK1 36
  • 89 (a)
(Canis familiaris)
Mammalia RIOK1 35
  • 89.44 (n)
  • 89.08 (a)
RIOK1 36
  • 89 (a)
(Mus musculus)
Mammalia Riok1 35
  • 82.53 (n)
  • 80.5 (a)
Riok1 16
Riok1 36
  • 79 (a)
(Pan troglodytes)
Mammalia RIOK1 35
  • 99.24 (n)
  • 98.77 (a)
RIOK1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Riok1 35
  • 83.3 (n)
  • 81.57 (a)
(Monodelphis domestica)
Mammalia RIOK1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia RIOK1 36
  • 85 (a)
(Gallus gallus)
Aves RIOK1 35
  • 75.73 (n)
  • 77.26 (a)
RIOK1 36
  • 75 (a)
(Anolis carolinensis)
Reptilia RIOK1 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia riok1 35
  • 73.81 (n)
  • 78.76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16329 35
(Danio rerio)
Actinopterygii Dr.3368 35
riok1 35
  • 66.85 (n)
  • 71.4 (a)
riok1 36
  • 71 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012121 35
  • 55.73 (n)
  • 56.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11660 35
  • 53.95 (n)
  • 55.82 (a)
CG11660 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea riok-1 35
  • 58.2 (n)
  • 57.84 (a)
riok-1 36
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER257W 35
  • 51.76 (n)
  • 45.18 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21121g 35
  • 52.6 (n)
  • 44.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIO1 35
  • 54.36 (n)
  • 47.68 (a)
RIO1 36
  • 37 (a)
RIO1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G37350 35
  • 55.58 (n)
  • 53.22 (a)
(Oryza sativa)
Liliopsida Os.17949 35
Os07g0162300 35
  • 54.25 (n)
  • 49.46 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10652 35
  • 52.1 (n)
  • 50.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.10 35
  • 55.33 (n)
  • 52.28 (a)
Species with no ortholog for RIOK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIOK1 Gene

Gene Tree for RIOK1 (if available)
Gene Tree for RIOK1 (if available)

Paralogs for RIOK1 Gene

Paralogs for RIOK1 Gene

(1) SIMAP similar genes for RIOK1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIOK1: view

Variants for RIOK1 Gene

Sequence variations from dbSNP and Humsavar for RIOK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3818425 -- 7,394,638(+) ACTTA(A/G)TATTT intron-variant
rs4461779 -- 7,413,803(+) TTTCT(C/T)TTCTT intron-variant
rs4959433 -- 7,391,775(+) GCAGA(A/G)GACAG intron-variant
rs4960314 -- 7,414,424(+) TTTAG(C/T)GTGGG intron-variant
rs12194656 -- 7,406,300(+) ccTCA(A/G)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIOK1 Gene

Variant ID Type Subtype PubMed ID
nsv462623 CNV Gain 19166990
nsv470797 CNV Gain 18288195
nsv883433 CNV Gain 21882294

Relevant External Links for RIOK1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIOK1 Gene

Disorders for RIOK1 Gene

Relevant External Links for RIOK1

Genetic Association Database (GAD)

No disorders were found for RIOK1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RIOK1 Gene

Publications for RIOK1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PMID: 15324660) Jin J. … Pawson T. (Curr. Biol. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for RIOK1 Gene

  • Addgene plasmids for RIOK1

Sources for RIOK1 Gene

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