RINL Gene
protein-coding GIFtS: 37
GCID: GC19M039358
|
|
Ras and Rab interactor-like
| |
Aliases
for RINL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ras And Rab Interactor-Like1 2 | | FLJ459091 | | Ras And Rab Interactor-Like Protein2 |
Export aliases for RINL gene to outside databasesPrevious GC identifers: GC19M044052 GC19M035805 |
Summaries
for RINL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RINL_HUMAN, Q6ZS11Function: Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchangingbound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity)
|
Genomic Views
for RINL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RINL gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 Tal-1beta MEF-2A E2F-1 E2F LyF-1 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RINL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RINL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2RINL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M039358: view genomic region
(about GC identifiers)
Start:
|
39,358,470 bp from pter |
End:
|
39,368,919 bp from pter |
Size:
|
10,450 bases |
Orientation:
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minus strand |
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Proteins
for RINL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RINL_HUMAN, Q6ZS11 (See
protein sequence)Recommended Name: Ras and Rab interactor-like protein Size: 452 amino acids; 50053 Da
Subunit: Interacts with RAB5A, RAB22A and MUSK (By similarity)
Subcellular location: Cell projection, ruffle (By similarity). Cytoplasmic vesicle (By similarity)Explore the universe of human proteins at neXtProt for RINL: NX_Q6ZS11
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZS11
RINL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001182762.1 NP_940847.1
ENSEMBL proteins: ENSP00000467107 ENSP00000340369 ENSP00000439962
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RINL for ontologies About GeneDecksing
RINL Antibody Products:
Assay Products for RINL: |
Protein
Domains /
Families
for RINL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RINL for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6ZS11ProtoNet protein and cluster: Q6ZS11 UniProtKB/Swiss-Prot: RINL_HUMAN, Q6ZS11Similarity: Contains 1 VPS9 domain |
Function
for RINL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RINL_HUMAN, Q6ZS11Function: Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchangingbound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RINL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RINL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RINL (NM_015532) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RINL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RINL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RINL |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity |
ISS | -- | | GO:0005096 | GTPase activator activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
RINL for ontologies About GeneDecksing
|
Pathways & Interactions
for RINL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RINL
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006897 | endocytosis |
ISS | -- | | GO:0015031 | protein transport |
IEA | -- |
RINL for ontologies About GeneDecksing
|
Drugs & Compounds
for RINL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RINL
Search CenterWatch for drugs/clinical trials and news about RINL
|
Transcripts
for RINL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RINL gene (2 alternative transcripts): NM_001195833.1 NM_198445.3 Unigene Cluster for RINL: Ras and Rab interactor-like Hs.446933 [show with all ESTs]Unigene Representative Sequence: NM_0011958334 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000589111 ENST00000591812 ENST00000340740(uc002ojq.3 uc010xuo.2 uc002ojr.1)
ENST00000536520
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RINL (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RINL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RINL (NM_015532) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RINL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RINL |
Additional cDNA sequence: AK124506.1 AK126119.1 AK298327.1 BC108703.1 5 DOTS entries: DT.101981908 DT.100679359 DT.99965360 DT.100021159 DT.121430969 24/34 AceView cDNA sequences (see all 34): AI873648 AA653541 AK127808 NM_198445 AA779599 BE044000 BI764140 CA848268 AA113117 AK126119 BI667625 AK124506 BQ268697 BG387967 AI524040 BQ691693 BX398488 CK825627 BI712120 BG754465 CD370038 BX432006 BG341381 BI713073
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RINL (see all 12) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RINL
|
Expression
for RINL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RINL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RINL Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.446933
SABiosciences Custom PCR Arrays for RINL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RINL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RINL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RINL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RINL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RINL |
Orthologs
for RINL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RINL gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for RINL (if available)
TreeFam Gene Tree for RINL (if available) |
Paralogs
for RINL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RINL gene
- RIN22 RIN32 RIN12
1 SIMAP similar gene for RINL using alignment to 4 protein entries: RINL_HUMAN (see all proteins):DKFZp762H1613
RINL for paralogs About GeneDecksing
|
Genomic Variants
for RINL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RINL (39358470 - 39368919 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RINL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RINL |
|
Disorders
/ Diseases
for RINL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RINL for disorders About MalaCards
RINL for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RINL (3 documents)
Export disorders for RINL gene to outside databases
|
Publications
for RINL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RINL gene integrated from 9 sources:
(articles sorted by number of sources associating them with RINL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- RINL, guanine nucleotide exchange factor Rab5-subfamil y, is involved in the EphA8-degradation pathway with odin. (PubMed id 22291991)1 Kajiho H....Katada T. (2012)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
|
External Searches for RINL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RINL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RINL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RINL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RINL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RINL gene:
Search GeneIP for patents involving RINL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RINL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RINL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RINL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RINL | | | OriGene Protein Over-expression Lysate for RINL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RINL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RINL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RINL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RINL | | OriGene Custom Protein Services for RINL | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RINL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RINL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RINL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RINL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RINL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RINL |
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| | | | Search Tocris compounds for RINL |
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 | | | RINL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RINL |
|  |  |  | | | | Search ThermoFisher Antibodies for RINL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RINL |
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