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Aliases for RINL Gene

Aliases for RINL Gene

  • Ras And Rab Interactor Like 2 3 5

External Ids for RINL Gene

Previous GeneCards Identifiers for RINL Gene

  • GC19M044052
  • GC19M039358
  • GC19M035805

Summaries for RINL Gene

GeneCards Summary for RINL Gene

RINL (Ras And Rab Interactor Like) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport. GO annotations related to this gene include GTPase activator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIN3.

UniProtKB/Swiss-Prot for RINL Gene

  • Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RINL Gene

Genomics for RINL Gene

Regulatory Elements for RINL Gene

Enhancers for RINL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F038810 1.4 Ensembl ENCODE 11.2 +62.1 62124 11.1 HDGF PKNOX1 ARNT SIN3A YY1 ZNF416 FOS ZNF263 SP3 NFYC ZNF573 LGALS7 FBXO17 RINL ZFP36 RPS16 ECH1 ACP7 LGALS4 ENSG00000269050
GH19F038861 1.4 Ensembl ENCODE 9.8 +14.0 13979 5.0 PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 YY1 ZNF548 FOS ZNF263 FBL ENSG00000269688 RN7SL566P RPS16 SUPT5H ENSG00000268756 ACTN4 EID2B RINL ENSG00000267892
GH19F038834 1.3 Ensembl ENCODE 10.4 +38.0 37956 11.0 HDGF PKNOX1 ARNT SIN3A FEZF1 YY1 ZNF766 ZNF143 ZNF548 FOS ENSG00000267892 LGALS7 RPS16 RINL ACTN4 LGALS4 LGALS7B ENSG00000268083 ENSG00000269688
GH19F038846 1.2 ENCODE 10.2 +28.1 28091 6.6 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 FBL RPS16 ENSG00000269688 ENSG00000266963 RN7SL566P ENSG00000267375 ENSG00000269172 ENSG00000269445 LGALS14 ENSG00000269792
GH19F038427 1.1 FANTOM5 ENCODE 6.5 +450.8 450778 0.3 HDGF ELF3 DRAP1 CTCF PKNOX1 MXI1 RAD21 RARA RELA ZNF316 RINL GMFG MAP4K1 LGALS7 RASGRP4 RYR1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RINL on UCSC Golden Path with GeneCards custom track

Promoters for RINL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001817458 -21 201 HDGF ELF3 KLF17 ZBTB40 RARA ZNF366 SCRT2 ETV6 THAP11 SP3

Genomic Location for RINL Gene

Chromosome:
19
Start:
38,867,830 bp from pter
End:
38,878,279 bp from pter
Size:
10,450 bases
Orientation:
Minus strand

Genomic View for RINL Gene

Genes around RINL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RINL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RINL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RINL Gene

Proteins for RINL Gene

  • Protein details for RINL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS11-RINL_HUMAN
    Recommended name:
    Ras and Rab interactor-like protein
    Protein Accession:
    Q6ZS11
    Secondary Accessions:
    • B4DPG5

    Protein attributes for RINL Gene

    Size:
    566 amino acids
    Molecular mass:
    62466 Da
    Quaternary structure:
    • Interacts with RAB5A, RAB22A and MUSK.

    Alternative splice isoforms for RINL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RINL Gene

Post-translational modifications for RINL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RINL Gene

Domains & Families for RINL Gene

Gene Families for RINL Gene

Protein Domains for RINL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RINL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZS11

UniProtKB/Swiss-Prot:

RINL_HUMAN :
  • Contains 1 VPS9 domain.
Domain:
  • Contains 1 VPS9 domain.
genes like me logo Genes that share domains with RINL: view

Function for RINL Gene

Molecular function for RINL Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).

Gene Ontology (GO) - Molecular Function for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA,ISS --
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with RINL: view

Phenotypes for RINL Gene

genes like me logo Genes that share phenotypes with RINL: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RINL Gene

Localization for RINL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RINL Gene

Cell projection, ruffle. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RINL gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0015629 actin cytoskeleton IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with RINL: view

Pathways & Interactions for RINL Gene

genes like me logo Genes that share pathways with RINL: view

Pathways by source for RINL Gene

2 Reactome pathways for RINL Gene

Interacting Proteins for RINL Gene

Gene Ontology (GO) - Biological Process for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis ISS --
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RINL: view

No data available for SIGNOR curated interactions for RINL Gene

Transcripts for RINL Gene

Unigene Clusters for RINL Gene

Ras and Rab interactor-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RINL Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:

Relevant External Links for RINL Gene

GeneLoc Exon Structure for
RINL
ECgene alternative splicing isoforms for
RINL

Expression for RINL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RINL Gene

mRNA differential expression in normal tissues according to GTEx for RINL Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for RINL Gene

This gene is overexpressed in Pancreatic juice (36.6) and Peripheral blood mononuclear cells (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RINL Gene



Protein tissue co-expression partners for RINL Gene

NURSA nuclear receptor signaling pathways regulating expression of RINL Gene:

RINL

SOURCE GeneReport for Unigene cluster for RINL Gene:

Hs.446933
genes like me logo Genes that share expression patterns with RINL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RINL Gene

Orthologs for RINL Gene

This gene was present in the common ancestor of animals.

Orthologs for RINL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RINL 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia RINL 34 35
  • 81.9 (n)
dog
(Canis familiaris)
Mammalia RINL 34 35
  • 81.55 (n)
mouse
(Mus musculus)
Mammalia Rinl 34 16 35
  • 77.24 (n)
rat
(Rattus norvegicus)
Mammalia Rinl 34
  • 75.63 (n)
oppossum
(Monodelphis domestica)
Mammalia RINL 35
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 14 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia RINL 35
  • 19 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01056375.1 35
  • 20 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta spri 35
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rin-1 35
  • 5 (a)
OneToMany
Species where no ortholog for RINL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RINL Gene

ENSEMBL:
Gene Tree for RINL (if available)
TreeFam:
Gene Tree for RINL (if available)

Paralogs for RINL Gene

Paralogs for RINL Gene

(2) SIMAP similar genes for RINL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RINL: view

Variants for RINL Gene

Sequence variations from dbSNP and Humsavar for RINL Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001413 -- 38,876,471(-) AGGTG(A/G)ACAAA reference, missense, utr-variant-5-prime
rs1001414 -- 38,876,174(-) gctga(A/G)gtggg intron-variant
rs10424892 -- 38,875,794(+) GCCCC(C/T)GGGAA intron-variant
rs1053876 -- 38,878,797(-) CTCCT(G/T)CCCCC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs11083482 -- 38,875,398(+) TGGCC(A/G)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RINL Gene

Variant ID Type Subtype PubMed ID
nsv1160616 CNV duplication 26073780

Variation tolerance for RINL Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.18; 92.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RINL Gene

Human Gene Mutation Database (HGMD)
RINL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RINL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RINL Gene

Disorders for RINL Gene

Relevant External Links for RINL

Genetic Association Database (GAD)
RINL
Human Genome Epidemiology (HuGE) Navigator
RINL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RINL

No disorders were found for RINL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RINL Gene

Publications for RINL Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin. (PMID: 22291991) Kajiho H. … Katada T. (PLoS ONE 2012) 3 64
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for RINL Gene

Sources for RINL Gene

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