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Aliases for RINL Gene

Aliases for RINL Gene

  • Ras And Rab Interactor Like 2 3 5

External Ids for RINL Gene

Previous GeneCards Identifiers for RINL Gene

  • GC19M044052
  • GC19M039358
  • GC19M035805

Summaries for RINL Gene

GeneCards Summary for RINL Gene

RINL (Ras And Rab Interactor Like) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIN3.

UniProtKB/Swiss-Prot for RINL Gene

  • Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).

Additional gene information for RINL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RINL Gene

Genomics for RINL Gene

GeneHancer (GH) Regulatory Elements for RINL Gene

Promoters and enhancers for RINL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I038876 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 556 -0.9 -866 4.9 HDGF SMAD1 ZNF133 ZNF48 ZNF121 SP3 ZNF518A KAT8 GLIS1 NBN RINL PAF1 SUPT5H SAMD4B LGALS7 LRFN1 LGALS4 FBXO17 ENSG00000267892 GC19M038871
GH19I038846 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 +28.1 28091 6.6 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 HNRNPL FBL ENSG00000269688 PLEKHG2 RN7SL566P RPS16 PAK4 PAF1 SUPT5H ENSG00000267892
GH19I038810 Promoter/Enhancer 1.7 EPDnew ENCODE dbSUPER 11.2 +62.1 62124 11.1 FOXA2 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF121 ZNF766 ZNF416 KLF7 LGALS4 ZNF573 HNRNPL ENSG00000269688 LGALS7 EID2B SUPT5H RN7SL566P LOC100631378 RINL
GH19I038862 Enhancer 1.5 Ensembl ENCODE dbSUPER 9.8 +14.0 13985 4.2 PKNOX1 ARNT SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF213 ZNF548 FOS HNRNPL FBL PLEKHG2 RN7SL566P ENSG00000269688 RPS16 EID2B PAF1 SUPT5H ENSG00000268756
GH19I038834 Enhancer 1.2 ENCODE dbSUPER 10.3 +38.7 38707 9.5 PKNOX1 CLOCK FOXA2 NEUROD1 SIN3A FEZF1 YY1 POLR2B GLIS2 ZNF213 ENSG00000268083 HNRNPL PLEKHG2 ENSG00000267892 EID2B MED29 PAK4 RN7SL566P LGALS7 DPF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RINL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RINL gene promoter:

Genomic Locations for RINL Gene

Genomic Locations for RINL Gene
chr19:38,867,830-38,878,279
(GRCh38/hg38)
Size:
10,450 bases
Orientation:
Minus strand
chr19:39,358,470-39,368,919
(GRCh37/hg19)

Genomic View for RINL Gene

Genes around RINL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RINL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RINL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RINL Gene

Proteins for RINL Gene

  • Protein details for RINL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS11-RINL_HUMAN
    Recommended name:
    Ras and Rab interactor-like protein
    Protein Accession:
    Q6ZS11
    Secondary Accessions:
    • B4DPG5

    Protein attributes for RINL Gene

    Size:
    566 amino acids
    Molecular mass:
    62466 Da
    Quaternary structure:
    • Interacts with RAB5A, RAB22A and MUSK.

    Alternative splice isoforms for RINL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RINL Gene

Post-translational modifications for RINL Gene

No Post-translational modifications

No data available for DME Specific Peptides for RINL Gene

Domains & Families for RINL Gene

Gene Families for RINL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RINL Gene

Suggested Antigen Peptide Sequences for RINL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RINL: view

No data available for UniProtKB/Swiss-Prot for RINL Gene

Function for RINL Gene

Molecular function for RINL Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).

Phenotypes From GWAS Catalog for RINL Gene

Gene Ontology (GO) - Molecular Function for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS,IEA --
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with RINL: view

Phenotypes for RINL Gene

genes like me logo Genes that share phenotypes with RINL: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RINL Gene

Localization for RINL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RINL Gene

Cell projection, ruffle. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RINL gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 1
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0015629 actin cytoskeleton IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with RINL: view

Pathways & Interactions for RINL Gene

genes like me logo Genes that share pathways with RINL: view

Pathways by source for RINL Gene

Interacting Proteins for RINL Gene

Gene Ontology (GO) - Biological Process for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis ISS --
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with RINL: view

No data available for SIGNOR curated interactions for RINL Gene

Drugs & Compounds for RINL Gene

No Compound Related Data Available

Transcripts for RINL Gene

Unigene Clusters for RINL Gene

Ras and Rab interactor-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RINL Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:

Relevant External Links for RINL Gene

GeneLoc Exon Structure for
RINL
ECgene alternative splicing isoforms for
RINL

Expression for RINL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RINL Gene

mRNA differential expression in normal tissues according to GTEx for RINL Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for RINL Gene

This gene is overexpressed in Pancreatic juice (36.6) and Peripheral blood mononuclear cells (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RINL Gene



Protein tissue co-expression partners for RINL Gene

NURSA nuclear receptor signaling pathways regulating expression of RINL Gene:

RINL

SOURCE GeneReport for Unigene cluster for RINL Gene:

Hs.446933

Evidence on tissue expression from TISSUES for RINL Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with RINL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RINL Gene

Orthologs for RINL Gene

This gene was present in the common ancestor of animals.

Orthologs for RINL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RINL 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia RINL 33 34
  • 81.9 (n)
dog
(Canis familiaris)
Mammalia RINL 33 34
  • 81.55 (n)
mouse
(Mus musculus)
Mammalia Rinl 33 16 34
  • 77.24 (n)
rat
(Rattus norvegicus)
Mammalia Rinl 33
  • 75.63 (n)
oppossum
(Monodelphis domestica)
Mammalia RINL 34
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 14 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia RINL 34
  • 19 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01056375.1 34
  • 20 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta spri 34
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rin-1 34
  • 5 (a)
OneToMany
Species where no ortholog for RINL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RINL Gene

ENSEMBL:
Gene Tree for RINL (if available)
TreeFam:
Gene Tree for RINL (if available)

Paralogs for RINL Gene

Paralogs for RINL Gene

(2) SIMAP similar genes for RINL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RINL: view

Variants for RINL Gene

Sequence variations from dbSNP and Humsavar for RINL Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000582023 -- 38,879,506(-) G/A upstream_transcript_variant
rs1000713651 -- 38,871,338(-) CTTA/CTTACTTA intron_variant
rs1000744889 -- 38,871,092(-) T/A coding_sequence_variant, missense_variant
rs1000968532 -- 38,875,170(-) A/T intron_variant
rs1000999891 -- 38,874,987(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RINL Gene

Variant ID Type Subtype PubMed ID
nsv1160616 CNV duplication 26073780

Variation tolerance for RINL Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.18; 92.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RINL Gene

Human Gene Mutation Database (HGMD)
RINL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RINL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RINL Gene

Disorders for RINL Gene

Additional Disease Information for RINL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RINL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RINL Gene

Publications for RINL Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin. (PMID: 22291991) Kajiho H … Katada T (PloS one 2012) 3 58
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for RINL Gene

Sources for RINL Gene

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