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Aliases for RINL Gene

Aliases for RINL Gene

  • Ras And Rab Interactor-Like 2 3
  • GRINL1A 6
  • POLR2M 6
  • GDOWN 6

External Ids for RINL Gene

Summaries for RINL Gene

GeneCards Summary for RINL Gene

RINL (Ras And Rab Interactor-Like) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIN3.

UniProtKB/Swiss-Prot for RINL Gene

  • Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RINL Gene

Genomics for RINL Gene

Genomic Location for RINL Gene

Start:
38,867,830 bp from pter
End:
38,878,279 bp from pter
Size:
10,450 bases
Orientation:
Minus strand

Genomic View for RINL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RINL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RINL Gene

Regulatory Elements for RINL Gene

Proteins for RINL Gene

  • Protein details for RINL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS11-RINL_HUMAN
    Recommended name:
    Ras and Rab interactor-like protein
    Protein Accession:
    Q6ZS11
    Secondary Accessions:
    • B4DPG5

    Protein attributes for RINL Gene

    Size:
    566 amino acids
    Molecular mass:
    62466 Da
    Quaternary structure:
    • Interacts with RAB5A, RAB22A and MUSK.

    Alternative splice isoforms for RINL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RINL Gene

Proteomics data for RINL Gene at MOPED

Post-translational modifications for RINL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RINL Gene

No data available for DME Specific Peptides for RINL Gene

Domains for RINL Gene

Protein Domains for RINL Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RINL_HUMAN
Domain:
  • Contains 1 VPS9 domain.:
    • Q6ZS11
genes like me logo Genes that share domains with RINL: view

No data available for Gene Families for RINL Gene

Function for RINL Gene

Molecular function for RINL Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).

Gene Ontology (GO) - Molecular Function for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RINL: view

miRNA for RINL Gene

miRTarBase miRNAs that target RINL

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RINL Gene

Localization for RINL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RINL Gene

Cell projection, ruffle. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RINL Gene COMPARTMENTS Subcellular localization image for RINL gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0015629 actin cytoskeleton IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with RINL: view

Pathways for RINL Gene

SuperPathways for RINL Gene

No Data Available

Interacting Proteins for RINL Gene

Gene Ontology (GO) - Biological Process for RINL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis ISS --
GO:0015031 protein transport IEA --
GO:0043547 positive regulation of GTPase activity ISS --
genes like me logo Genes that share ontologies with RINL: view

No data available for Pathways by source for RINL Gene

Transcripts for RINL Gene

Unigene Clusters for RINL Gene

Ras and Rab interactor-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RINL Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8: - - - -
SP9: - - -
SP10:
SP11:
SP12:

Relevant External Links for RINL Gene

GeneLoc Exon Structure for
RINL
ECgene alternative splicing isoforms for
RINL

Expression for RINL Gene

mRNA expression in normal human tissues for RINL Gene

mRNA differential expression in normal tissues according to GTEx for RINL Gene

This gene is overexpressed in Whole Blood (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RINL Gene

SOURCE GeneReport for Unigene cluster for RINL Gene Hs.446933

genes like me logo Genes that share expressions with RINL: view

Orthologs for RINL Gene

This gene was present in the common ancestor of animals.

Orthologs for RINL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RINL 36
  • 99.35 (n)
  • 99.29 (a)
RINL 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RINL 36
  • 81.9 (n)
  • 74.29 (a)
RINL 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RINL 36
  • 81.55 (n)
  • 74.11 (a)
RINL 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rinl 36
  • 77.24 (n)
  • 71.64 (a)
Rinl 16
Rinl 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RINL 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 14 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rinl 36
  • 75.63 (n)
  • 69.24 (a)
lizard
(Anolis carolinensis)
Reptilia RINL 37
  • 19 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01056375.1 37
  • 20 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta spri 37
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rin-1 37
  • 5 (a)
OneToMany
Species with no ortholog for RINL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RINL Gene

ENSEMBL:
Gene Tree for RINL (if available)
TreeFam:
Gene Tree for RINL (if available)

Paralogs for RINL Gene

Paralogs for RINL Gene

Selected SIMAP similar genes for RINL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RINL: view

Variants for RINL Gene

Sequence variations from dbSNP and Humsavar for RINL Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1001413 -- 38,876,471(-) AGGTG(A/G)ACAAA reference, missense, utr-variant-5-prime
rs1001414 -- 38,876,174(-) gctga(A/G)gtggg intron-variant
rs1529713 -- 38,876,259(+) GTGTC(A/G)TGTTT intron-variant
rs2318462 -- 38,877,659(+) TCTCT(C/T)CATCC intron-variant
rs5828019 -- 38,876,060(+) TTACA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RINL Gene

Variant ID Type Subtype PubMed ID
nsv911673 CNV Loss 21882294

Relevant External Links for RINL Gene

HapMap Linkage Disequilibrium report
RINL

Disorders for RINL Gene

Relevant External Links for RINL

Genetic Association Database (GAD)
RINL
Human Genome Epidemiology (HuGE) Navigator
RINL
genes like me logo Genes that share disorders with RINL: view

No data available for UniProtKB/Swiss-Prot for RINL Gene

Publications for RINL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  3. RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin. (PMID: 22291991) Kajiho H. … Katada T. (PLoS ONE 2012) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for RINL Gene

Sources for RINL Gene

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