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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RINL Gene

protein-coding   GIFtS: 41
GCID: GC19M039358

Ras And Rab Interactor-Like

  Search for RINL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras And Rab Interactor-Like1 2
Ras And Rab Interactor-Like Protein2

External Ids:    HGNC: 247951   Entrez Gene: 1264322   Ensembl: ENSG000001879947   UniProtKB: Q6ZS113   

Export aliases for RINL gene to outside databases

Previous GC identifers: GC19M044052 GC19M035805


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RINL Gene: 
RINL (Ras and Rab interactor-like) is a protein-coding gene. GO annotations related to this gene include GTPase activator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIN2.

UniProtKB/Swiss-Prot: RINL_HUMAN, Q6ZS11
Function: Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by
exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RINL gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   Tal-1beta   MEF-2A   E2F-1   E2F   LyF-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRINL promoter sequence
   Search SABiosciences Chromatin IP Primers for RINL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RINL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

RINL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RINL gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M039358:  view genomic region     (about GC identifiers)

Start:
39,358,470 bp from pter      End:
39,368,919 bp from pter
Size:
10,450 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RINL_HUMAN, Q6ZS11 (See protein sequence)
Recommended Name: Ras and Rab interactor-like protein  
Size: 566 amino acids; 62466 Da
Subunit: Interacts with RAB5A, RAB22A and MUSK (By similarity)
Subcellular location: Cell projection, ruffle (By similarity). Cytoplasmic vesicle (By similarity)
Secondary accessions: B4DPG5
Alternative splicing: 2 isoforms:  Q6ZS11-1   Q6ZS11-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RINL: NX_Q6ZS11

Explore proteomics data for RINL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZS11

  • RINL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RINL Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001182762.1  NP_940847.1  

    ENSEMBL proteins: 
     ENSP00000469568   ENSP00000467107   ENSP00000469510   ENSP00000470224   ENSP00000340369  

    Human Recombinant Protein Products for RINL: 
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    Novus Biologicals RINL Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RINL 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0015629actin cytoskeleton IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    RINL for ontologies           About GeneDecksing



    RINL Antibody Products: 
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    Cloud-Clone Corp. ELISAs for RINL 
    Cloud-Clone Corp. CLIAs for RINL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003123 VPS9

    Graphical View of Domain Structure for InterPro Entry Q6ZS11

    ProtoNet protein and cluster: Q6ZS11

    UniProtKB/Swiss-Prot: RINL_HUMAN, Q6ZS11
    Similarity: Contains 1 VPS9 domain


    RINL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RINL_HUMAN, Q6ZS11
    Function: Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by
    exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ISS--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
         
    RINL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RINL 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RINL 
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    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RINL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RINL

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis ISS--
    GO:0015031protein transport IEA--

    RINL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RINL

    Search CenterWatch for drugs/clinical trials and news about RINL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RINL gene (2 alternative transcripts): 
    NM_001195833.1  NM_198445.3  

    Unigene Cluster for RINL:

    Ras and Rab interactor-like
    Hs.446933  [show with all ESTs]
    Unigene Representative Sequence: NM_001195833
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598904 ENST00000589111 ENST00000591812 ENST00000593424 ENST00000596961
    ENST00000593809 ENST00000602238 ENST00000596919 ENST00000599911 ENST00000598048
    ENST00000340740(uc002ojq.3 uc010xuo.2 uc002ojr.1)
    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RINL
    SwitchGear 3'UTR luciferase reporter plasmidRINL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RINL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RINL
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    GenScript: all cDNA clones in your preferred vector (see all 2): RINL (NM_015532)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RINL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RINL
    Sirion Biotech Customized lentivirus for stable overexpression of RINL 
                         Customized lentivirus expression plasmids for stable overexpression of RINL 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RINL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RINL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RINL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RINL

    Additional mRNA sequence: 

    AK124506.1 AK126119.1 AK298327.1 BC108703.1 

    5 DOTS entries:

    DT.101981908  DT.100679359  DT.99965360  DT.100021159  DT.121430969 

    24/34 AceView cDNA sequences (see all 34):

    BE044000 AA779599 AK126119 AK127808 AI873648 AA113117 NM_198445 AA653541 
    BI764140 CA848268 BG341381 BG754465 AK124506 CD370038 BX432006 BQ691693 
    BQ268697 BX398488 BG387967 CK825627 BI667625 AI524040 BI712120 BI713073 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RINL (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:              -                       -                 -     -                                                                                       
    SP2:                                                                                                              -                 -                     
    SP3:                                                                                                              -                 -     -     -         
    SP4:              -                                                                                                                                       
    SP5:                                      -                                                                                                               


    ECgene alternative splicing isoforms for RINL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RINL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RINL Expression
    About this image


    See RINL Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.446933
        SABiosciences Custom PCR Arrays for RINL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RINL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RINL gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rinl1 , 5 Ras and Rab interactor-like1, 5 76.51(n)1
    71.19(a)1
      7 (16.93 cM)5
    3204351  NM_177158.51  NP_796132.21 
     287889695 
    lizard
    (Anolis carolinensis)
    Reptilia RINL6
    Uncharacterized protein
    18(a)
    1 ↔ 1
    GL343958.1(19732-41830)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01056375.16
    Uncharacterized protein
    15(a)
    1 ↔ 1
    15(6698690-6722616)
    fruit fly
    (Drosophila melanogaster)
    Insecta spri6
    sprint
    4(a)
    1 → many
    X(10384102-10479455)
    worm
    (Caenorhabditis elegans)
    Secernentea rin-16
    Protein TAG-333, isoform f
    3(a)
    1 → many
    V(14784152-14815600)


    ENSEMBL Gene Tree for RINL (if available)
    TreeFam Gene Tree for RINL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RINL gene
    RIN22  RIN12  RIN32  
    2 SIMAP similar genes for RINL using alignment to 3 protein entries:     RINL_HUMAN (see all proteins):
    RIN2    DKFZp762H1613

    RINL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/277 SNPs in RINL are shown (see all 277)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344108771,2
    C--35811579(+) CAGGA-/T/TT  
            
    TTTTT
    2 -- int12NA CSA 4
    rs1405857801,2
    C--39358174(+) AAAGT-/TATATAT 2 -- ds50010--------
    rs1807114381,2
    --39358504(+) GGATAC/TATGTT 2 -- ut310--------
    rs767471681,2
    C,F--39358640(+) GGAGTG/ACAATG 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs784551481,2
    C--39358680(+) CTCCCA/GGGTTC 2 -- ut310--------
    rs118818371,2
    C,F,H--39358860(+) gattaC/Taggca 2 -- ut311Minor allele frequency- T:0.33NA 6
    rs1511426411,2
    C--39358861(+) ATTACA/GGGCAT 2 -- ut310--------
    rs1902402051,2
    C--39358881(+) CACCCA/GGCCTC 2 -- ut310--------
    rs1396022981,2
    --39359001(+) GGCACC/GGTGGC 2 -- ut310--------
    rs1180123171,2
    F--39359038(+) GAGGCC/TGACGT 2 -- ut311Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for RINL (39358470 - 39368919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RINL:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911673CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RINL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RINL for disorders           About MalaCards

    RINL for disorders           About GeneDecksing

    Genetic Association Database (GAD): RINL
    Human Genome Epidemiology (HuGE) Navigator: RINL (3 documents)

    Export disorders for RINL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RINL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RINL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. RINL, guanine nucleotide exchange factor Rab5-subfamil y, is involved in the EphA8-degradation pathway with odin. (PubMed id 22291991)1 Kajiho H....Katada T. (2012)
    4. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126432 HGNC: 24795 AceView: FLJ45909 Ensembl:ENSG00000187994 euGenes: HUgn126432
    ECgene: RINL H-InvDB: RINL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RINL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RINL gene:
    Search GeneIP for patents involving RINL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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