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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RING1 Gene

protein-coding   GIFtS: 62
GCID: GC06P033196

Ring Finger Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 11 2 3     RING1A2
RNF12 3 5     E3 Ubiquitin-Protein Ligase RING12
Polycomb Complex Protein RING12 3     EC 6.3.2.-3
Really Interesting New Gene 1 Protein2 3     EC 6.3.28

External Ids:    HGNC: 100181   Entrez Gene: 60152   Ensembl: ENSG000002042277   OMIM: 6020455   UniProtKB: Q065873   

Export aliases for RING1 gene to outside databases

Previous GC identifers: GC06P033179 GC06P033169 GC06P033223 GC06P033284 GC06P033177 GC06P032920 GC06P033187


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RING1 Gene:
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a
zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a
transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product
interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large
nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the
HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. (provided by RefSeq, Jul
2008)

GeneCards Summary for RING1 Gene: 
RING1 (ring finger protein 1) is a protein-coding gene. Diseases associated with RING1 include occult macular dystrophy, and embryonal cancer, and among its related super-pathways are Notch signaling pathway and Signal transduction Activin A signaling regulation. GO annotations related to this gene include ubiquitin-protein ligase activity and chromatin binding. An important paralog of this gene is RNF2.

UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
Function: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of
histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination
gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of
female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class
required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout
development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin
heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase
activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity

Gene Wiki entry for RING1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RING1 gene promoter:
         Sp1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RING1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RING1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

RING1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RING1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033196:  view genomic region     (about GC identifiers)

Start:
33,176,272 bp from pter      End:
33,180,499 bp from pter
Size:
4,228 bases      Orientation:
plus strand

5 alternative locations:
Chr6+,NT_167245 4,457,593-4,461,806      Chr6+,NT_167247 4,650,047-4,654,260      Chr6+,NT_167246 4,633,606-4,637,819     
Chr6+,NT_167248 4,408,513-4,412,726      Chr6+,NT_113891.2 4,620,116-4,624,329     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RING1  
Size: 406 amino acids; 42429 Da
Subunit: Component of chromatin-associated Polycomb (PcG) complexes. Interacts with BMI1 (By similarity). Part of
the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2
MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive
BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2.
Interacts with PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with PHC2 (By similarity)
Subcellular location: Nucleus. Nucleus speckle
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of
different PRC1-like complexes
Secondary accessions: A8JZZ0 Q5JP96 Q5SQW2 Q86V19
Alternative splicing: 2 isoforms:  Q06587-1   Q06587-2   

Explore the universe of human proteins at neXtProt for RING1: NX_Q06587

Explore proteomics data for RING1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q06587

  • 4/14 DME Specific Peptides for RING1 (Q06587) (see all 14)
     EIELVFR  QTRYVKTT  SEKQYTIYI  LISKIYPSR 

    RING1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RING1 Protein Expression
    REFSEQ proteins: NP_002922.2  
    ENSEMBL proteins: 
     ENSP00000363787  

    Human Recombinant Protein Products for RING1: 
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    Novus Biologicals RING1 Proteins
    Novus Biologicals RING1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IEA--
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    RING1 for ontologies           About GeneDecksing



    RING1 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR018957 Znf_C3HC4_RING-type

    Graphical View of Domain Structure for InterPro Entry Q06587

    ProtoNet protein and cluster: Q06587

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
    Similarity: Contains 1 RING-type zinc finger


    RING1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RING1_HUMAN, Q06587
    Function: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of
    histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination
    gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of
    female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class
    required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout
    development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin
    heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase
    activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI15386022
    GO:0008270zinc ion binding NAS--
    GO:0046872metal ion binding ----
         
    RING1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RING1:
     Cell cycle / mitosis defect  Increased circadian period len  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ring1):
     skeleton 

    RING1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ring1tm1Mvi for RING1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RING1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RING1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RING1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RING1 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidRING1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RING1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Notch signaling pathway
    Delta-Notch Signaling Pathway0.33
    2Signal transduction Activin A signaling regulation
    Histone modification0.31
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Protein Stability
    Protein Stability
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RING1
        Histone modification


    3 Cell Signaling Technology (CST) Pathways for RING1
        Chromatin Regulation / Acetylation
    Wnt / Hedgehog / Notch
    Protein Stability

    1 BioSystems Pathway for RING1
        Delta-Notch Signaling Pathway



    UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
    Pathway: Protein modification; protein ubiquitination


    RING1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RING1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/655 Interacting proteins for RING1 (Q065871, 2, 3 ENSP000003637874) via UniProtKB, MINT, STRING, and/or I2D (see all 655)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF2Q994961, 2, 3, ENSP000003564804EBI-752313,EBI-722416 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 STRING: ENSP00000356480
    CBX8Q9HC521, 2, 3, ENSP000002693854EBI-752313,EBI-712912 MINT-8010325 MINT-8010390 MINT-8001946 I2D: score=3 STRING: ENSP00000269385
    PCGF2P352271, 2, 3, ENSP000003540334EBI-752313,EBI-2129767 MINT-8010390 MINT-8001946 I2D: score=1 STRING: ENSP00000354033
    USP11P517842, 3MINT-7999769 MINT-7999820 MINT-8010325 MINT-8010390 MINT-8001946 MINT-8012708 MINT-8010231 I2D: score=2 
    USP7Q930092, 3MINT-7999820 MINT-7999745 MINT-8012697 MINT-8010240 MINT-8010390 MINT-8001946 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0016568chromatin modification NAS--
    GO:0016574histone ubiquitination ----
    GO:0035518histone H2A monoubiquitination IDA16943429

    RING1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RING1

    4 HMDB Compounds for RING1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about RING1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RING1 gene: 
    NM_002931.3  

    Unigene Cluster for RING1:

    Ring finger protein 1
    Hs.631989  [show with all ESTs]
    Unigene Representative Sequence: BC002922
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374656(uc011dqw.1 uc011dqx.1 uc003odk.3) ENST00000478431(uc003odl.3)

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    Additional mRNA sequence: 

    AK289355.1 AK297552.1 AK301010.1 AK301378.1 BC002922.2 BC051866.2 BT007352.1 Z14000.1 

    7 DOTS entries:

    DT.412366  DT.100778150  DT.97843560  DT.95083717  DT.95083723  DT.121359271  DT.121359279 

    24/165 AceView cDNA sequences (see all 165):

    BX100281 CD724037 CR604365 CD673754 CR606762 CR594955 AI524778 BM555184 
    AU104696 BU072329 BI259576 CF132233 BF880059 CB269896 BM699973 BM726132 
    CD673971 NM_002931 BQ066472 BQ637475 AL576514 AU099197 CN482549 AW207576 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RING1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTATCCCT
    RING1 Expression
    About this image


    See RING1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RING1

    SOURCE GeneReport for Unigene cluster: Hs.631989
        SABiosciences Expression via Pathway-Focused PCR Arrays including RING1: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RING1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RING1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ring11 , 5 ring finger protein 11, 5 88.67(n)1
    96.55(a)1
      17 (17.98 cM)5
    197631  NM_009066.31  NP_033092.31 
     340207925 
    lizard
    (Anolis carolinensis)
    Reptilia RING16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL344367.1(29442-41888)
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.13102 Oncorhynchus mykiss transcribed sequence with weak more 77.74(n)    BX072591.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ring3   -- 78(a)   98B1   --


    ENSEMBL Gene Tree for RING1 (if available)
    TreeFam Gene Tree for RING1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RING1 gene
    RNF22  
    1 SIMAP similar gene for RING1 using alignment to 1 protein entry:     RING1_HUMAN:
    RNF2

    RING1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/127 SNPs in RING1 are shown (see all 127)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471963931,2
    C--33176458(+) CGGGGA/GCGGAG 1 -- int10--------
    rs1870137581,2
    --33176710(+) ACCCCC/GTCCCC 1 -- int10--------
    rs1147590121,2
    C,F--33176749(+) CACAGC/TTTCTT 1 -- int11Minor allele frequency- T:0.14WA 118
    rs1902012731,2
    --33176895(+) TCATTG/TGAAAG 1 -- int10--------
    rs1152016241,2
    C,F--33176937(+) CTCATT/CCAGTG 1 -- int12Minor allele frequency- C:0.03WA NA 238
    rs2132091,2
    C,F,A,H--33176958(-) CTTATG/ATGCAC 1 -- int128Minor allele frequency- A:0.43EA NA MN NS WA CSA 3168
    rs1407729541,2
    --33177123(+) TTTTTC/TCCAAC 1 -- int10--------
    rs1148877731,2
    C,F--33177160(+) AGGCCA/GCTTAG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs92960891,2
    C,F,H--33177341(+) GGGCTG/ACTGTT 1 -- int1 ese33Minor allele frequency- A:0.01NS NA 274
    rs1825940081,2
    C--33177650(+) TCAGTA/TCCCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RING1 (33176272 - 33180499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RING1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv885768CNV Loss21882294
    nsv830634CNV Loss17160897
    nsv522719CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602045    OMIM disorders: --

    17 diseases for RING1:    About MalaCards
    occult macular dystrophy    embryonal cancer    partial central choroid dystrophy    choroiditis
    synovial sarcoma    adenoiditis    myelodysplastic syndromes    b-cell lymphomas
    type 1 diabetes    hodgkin's lymphoma    sarcoma    mental retardation
    renal cell carcinoma    systemic lupus erythematosus    lupus erythematosus    prostate cancer
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for RING1:
    Adenoiditis     Occult macular dystrophy

    RING1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for RING1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 38.7 1 15470680 (1)
    tumors 8.71 9 16528373 (3), 18984978 (2), 14742259 (1)
    carcinoma 7.2 6 18984978 (4), 16528373 (2)
    lymphoma 4.7 1 14742259 (1)

    Genetic Association Database (GAD): RING1
    Human Genome Epidemiology (HuGE) Navigator: RING1 (9 documents)

    Export disorders for RING1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RING1 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with RING1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity. (PubMed id 9858531)1, 2, 9 Satijn D.P.E. and Otte A.P. (1999)
    2. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. (PubMed id 9199346)1, 2, 9 Satijn D.P.E.... Otte A.P. (1997)
    3. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2, 9 Gearhart M.D.... Bardwell V.J. (2006)
    4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (2011)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N....Peters G. (2009)
    8. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    9. Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B. (PubMed id 18830248)1, 4 Eike M.C....Lie B.A. (2008)
    10. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4 Horikawa Y....Wu X. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6015 HGNC: 10018 AceView: RING1 Ensembl:ENSG00000204227 euGenes: HUgn6015
    ECgene: RING1 H-InvDB: RING1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RING1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RING1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RING1 gene:
    Search GeneIP for patents involving RING1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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