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Aliases for RING1 Gene

Aliases for RING1 Gene

  • Ring Finger Protein 1 2 3
  • RNF1 3 4 6
  • Really Interesting New Gene 1 Protein 3 4
  • Polycomb Complex Protein RING1 3 4
  • E3 Ubiquitin-Protein Ligase RING1 3
  • RING Finger Protein 1 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • RING1A 3

External Ids for RING1 Gene

Summaries for RING1 Gene

Entrez Gene Summary for RING1 Gene

  • This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

GeneCards Summary for RING1 Gene

RING1 (Ring Finger Protein 1) is a Protein Coding gene. Diseases associated with RING1 include adenoiditis and occult macular dystrophy. Among its related pathways are Cellular Senescence and Protein Stability. GO annotations related to this gene include chromatin binding and ubiquitin-protein transferase activity. An important paralog of this gene is RNF2.

UniProtKB/Swiss-Prot for RING1 Gene

  • Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of Lys-119 of histone H2A, thereby playing a central role in histone code and gene regulation. H2A Lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Gene Wiki entry for RING1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RING1 Gene

Genomics for RING1 Gene

Genomic Location for RING1 Gene

Start:
33,208,495 bp from pter
End:
33,212,722 bp from pter
Size:
4,228 bases
Orientation:
Plus strand

Genomic View for RING1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RING1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for RING1 Gene

Transcription factor binding sites by QIAGEN in the RING1 gene promoter:

Proteins for RING1 Gene

  • Protein details for RING1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06587-RING1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RING1
    Protein Accession:
    Q06587
    Secondary Accessions:
    • A8JZZ0
    • Q5JP96
    • Q5SQW2
    • Q86V19

    Protein attributes for RING1 Gene

    Size:
    406 amino acids
    Molecular mass:
    42429 Da
    Quaternary structure:
    • Component of chromatin-associated Polycomb (PcG) complexes. Interacts with BMI1 (By similarity). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with PHC2 (By similarity).
    Miscellaneous:
    • The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes

    Alternative splice isoforms for RING1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RING1 Gene

Proteomics data for RING1 Gene at MOPED

Post-translational modifications for RING1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys12, Lys275, and Lys297

Other Protein References for RING1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for RING1 Gene

Gene Families for RING1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RING1 Gene

Suggested Antigen Peptide Sequences for RING1 Gene

Graphical View of Domain Structure for InterPro Entry

Q06587

UniProtKB/Swiss-Prot:

RING1_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q06587
genes like me logo Genes that share domains with RING1: view

Function for RING1 Gene

Molecular function for RING1 Gene

UniProtKB/Swiss-Prot Function: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of Lys-119 of histone H2A, thereby playing a central role in histone code and gene regulation. H2A Lys-119 ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

Enzyme Numbers (IUBMB) for RING1 Gene

Gene Ontology (GO) - Molecular Function for RING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 15386022
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RING1: view

Phenotypes for RING1 Gene

genes like me logo Genes that share phenotypes with RING1: view

Animal Models for RING1 Gene

MGI Knock Outs for RING1:

miRNA for RING1 Gene

miRTarBase miRNAs that target RING1

No data available for Transcription Factor Targeting and HOMER Transcription for RING1 Gene

Localization for RING1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RING1 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RING1 Gene COMPARTMENTS Subcellular localization image for RING1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex --
GO:0001739 sex chromatin IEA --
GO:0005634 nucleus IDA 21282530
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RING1: view

Pathways for RING1 Gene

genes like me logo Genes that share pathways with RING1: view

Pathways by source for RING1 Gene

3 Cell Signaling Technology pathways for RING1 Gene
1 BioSystems pathway for RING1 Gene

UniProtKB/Swiss-Prot Q06587-RING1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RING1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0016574 histone ubiquitination --
GO:0016925 protein sumoylation TAS --
GO:0035518 histone H2A monoubiquitination IDA 16943429
genes like me logo Genes that share ontologies with RING1: view

Compounds for RING1 Gene

(4) HMDB Compounds for RING1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with RING1: view

Transcripts for RING1 Gene

mRNA/cDNA for RING1 Gene

Unigene Clusters for RING1 Gene

Ring finger protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RING1 Gene

No ASD Table

Relevant External Links for RING1 Gene

GeneLoc Exon Structure for
RING1
ECgene alternative splicing isoforms for
RING1

Expression for RING1 Gene

mRNA expression in normal human tissues for RING1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RING1 Gene

SOURCE GeneReport for Unigene cluster for RING1 Gene Hs.631989

genes like me logo Genes that share expressions with RING1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RING1 Gene

Orthologs for RING1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RING1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RING1 35
  • 99.73 (n)
  • 99.73 (a)
RING1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RING1 35
  • 91.54 (n)
  • 98.77 (a)
RING1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RING1 35
  • 93.43 (n)
  • 98.52 (a)
RING1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ring1 35
  • 88.67 (n)
  • 96.55 (a)
Ring1 16
Ring1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RING1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RING1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ring1 35
  • 88.34 (n)
  • 96.8 (a)
lizard
(Anolis carolinensis)
Reptilia RING1 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ring1 35
  • 65.89 (n)
  • 74.27 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1310 35
fruit fly
(Drosophila melanogaster)
Insecta Sce 36
  • 41 (a)
OneToMany
Ring 37
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea spat-3 36
  • 2 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9967 36
  • 45 (a)
OneToMany
Species with no ortholog for RING1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RING1 Gene

ENSEMBL:
Gene Tree for RING1 (if available)
TreeFam:
Gene Tree for RING1 (if available)

Paralogs for RING1 Gene

Paralogs for RING1 Gene

Selected SIMAP similar genes for RING1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RING1: view

Variants for RING1 Gene

Sequence variations from dbSNP and Humsavar for RING1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs213208 -- 33,210,233(-) TCAGT(A/C)TGTGG intron-variant
rs213209 -- 33,209,181(-) CTTAT(A/G)TGCAC intron-variant
rs1047194 -- 33,212,432(+) GGACC(A/C)TGGGG utr-variant-3-prime
rs1704994 -- 33,208,739(-) AGGAG(G/T)GCGTC intron-variant
rs2744515 -- 33,208,691(-) aagcg(A/C)ccctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RING1 Gene

Variant ID Type Subtype PubMed ID
nsv885768 CNV Loss 21882294
nsv830634 CNV Loss 17160897
nsv522719 CNV Loss 19592680

Relevant External Links for RING1 Gene

HapMap Linkage Disequilibrium report
RING1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RING1 Gene

Disorders for RING1 Gene

(2) University of Copenhagen DISEASES for RING1 Gene

(4) Novoseek inferred disease relationships for RING1 Gene

Disease -log(P) Hits PubMed IDs
hodgkin disease 38.7 1
tumors 8.71 6
carcinoma 7.2 6
lymphoma 4.7 1

Relevant External Links for RING1

Genetic Association Database (GAD)
RING1
Human Genome Epidemiology (HuGE) Navigator
RING1
genes like me logo Genes that share disorders with RING1: view

No data available for UniProtKB/Swiss-Prot for RING1 Gene

Publications for RING1 Gene

  1. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. (PMID: 9199346) Satijn D.P.E. … Otte A.P. (Mol. Cell. Biol. 1997) 3 4 23
  2. RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity. (PMID: 9858531) Satijn D.P.E. … Otte A.P. (Mol. Cell. Biol. 1999) 3 4 23
  3. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PMID: 16943429) Gearhart M.D. … Bardwell V.J. (Mol. Cell. Biol. 2006) 3 4 23
  4. Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features. (PMID: 17134822) van Leenders G.J. … Raaphorst F.M. (Eur. Urol. 2007) 3 23
  5. New genes in the class II region of the human major histocompatibility complex. (PMID: 1906426) Hanson I.M. … Trowsdale J. (Genomics 1991) 2 3

Products for RING1 Gene

  • Addgene plasmids for RING1

Sources for RING1 Gene

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