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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RING1 Gene

protein-coding   GIFtS: 60
GCID: GC06P033187

ring finger protein 1
 Explore 17 diseases affiliated with
RING1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RING1    

Aliases
for RING1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ring Finger Protein 11 2 3     RING1A2
RNF11 2 3 5     E3 Ubiquitin-Protein Ligase RING12
Polycomb Complex Protein RING12 3     EC 6.3.2.-3
Really Interesting New Gene 1 Protein2 3     EC 6.3.28

External Ids:    HGNC: 100181   Entrez Gene: 60152   Ensembl: ENSG000002042277   OMIM: 6020455   UniProtKB: Q065873   

Export aliases for RING1 gene to outside databases

Previous GC identifers: GC06P033179 GC06P033169 GC06P033223 GC06P033284 GC06P033177 GC06P032920


Summaries
for RING1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RING1:
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a
zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional
repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the
polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It
interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region,
where it is contiguous with the RING finger genes FABGL and HKE4. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
Function: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone
H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific
tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.
Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the
transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts
via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.
Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act
as a modulator of RNF2/RING2 activity

Gene Wiki entry for RING1


Genomic Views
for RING1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RING1 gene promoter:
         Sp1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RING1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RING1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

RING1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RING1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033187:  view genomic region     (about GC identifiers)

Start:
 33,176,272 bp from pter      End:
 33,180,499 bp from pter
Size:
 4,228 bases      Orientation:
 plus strand

5 alternative locations:
Chr6+,ALT_REF_LOCI_4 33,253,265-33,257,478      Chr6+,ALT_REF_LOCI_3 33,154,182-33,169,447      Chr6+,ALT_REF_LOCI_5 33,261,470-33,265,683     
Chr6+,ALT_REF_LOCI_2 33,097,900-33,141,313      Chr6+,ALT_REF_LOCI_6 33,105,102-33,144,910     

Proteins
for RING1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RING1  
Size: 406 amino acids; 42429 Da
Subunit: Component of chromatin-associated Polycomb (PcG) complexes. Interacts with BMI1 (By similarity). Part of the
E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2 MBLR,
L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive BCOR
complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2. Interacts with
PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with PHC2 (By similarity)
Subcellular location: Nucleus. Nucleus speckle
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different
PRC1-like complexes
Secondary accessions: A8JZZ0 Q5JP96 Q5SQW2 Q86V19
Alternative splicing: 2 isoforms:  Q06587-1   Q06587-2   

Explore the universe of human proteins at neXtProt for RING1: NX_Q06587

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q06587

    • 4/14 DME Specific Peptides for RING1 (Q06587) (see all 14)
     EIELVFR  QTRYVKTT  SEKQYTIYI  LISKIYPSR 

    RING1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002922.2  
    ENSEMBL proteins: 
     ENSP00000363787  

    Human Recombinant Protein Products: 
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    Novus Biologicals RING1 Proteins
    Novus Biologicals RING1 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RING1

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IEA--
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    RING1 for ontologies           About GeneDecksing



    RING1 Antibody Products: 
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    Uscn Antibodies for RING1
    ThermoFisher Antibodies for RING1

    Assay Products for RING1: 
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    Uscn ELISAs and CLIAs for RING1

    Protein Domains /
    Families
    for RING1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RING1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q06587

    ProtoNet protein and cluster: Q06587

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RING1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
    Function: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone
    H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific
    tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals.
    Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the
    transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts
    via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility.
    Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act
    as a modulator of RNF2/RING2 activity

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
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    hsa-miR-3149 hsa-miR-3163 hsa-miR-607 hsa-miR-4286 hsa-miR-657 hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: RING1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RING1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for RING1

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding NAS--


    RING1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RING1:
     Cell cycle / mitosis defect  Increased circadian period len  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-out Ring1tm1Mvi for RING1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ring1):
     skeleton 

    RING1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RING1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    2Protein Stability
    		Protein Stability1.00
    3Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation1.00
    4Signal transduction Activin A signaling regulation
    		Histone modification0.31
    5Notch Signaling Pathway
    		Delta-Notch Signaling Pathway0.27

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RING1
        Histone modification


    3 Cell Signaling Technology (CST) Pathways for RING1
        Chromatin Regulation / Acetylation
    Wnt / Hedgehog / Notch
    Protein Stability

    1 BioSystems Pathway for RING1 
        Delta-Notch Signaling Pathway


    UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
    Pathway: Protein modification; protein ubiquitination


    RING1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RING1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/631 Interacting proteins for RING1 (Q065871, 2, 3 ENSP000003637874) via UniProtKB, MINT, STRING, and/or I2D (see all 631)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF2Q994961, 2, 3, ENSP000003564804EBI-752313,EBI-722416 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 STRING: ENSP00000356480
    CBX8Q9HC521, 2, 3, ENSP000002693854EBI-752313,EBI-712912 MINT-8010325 MINT-8010390 MINT-8001946 I2D: score=3 STRING: ENSP00000269385
    PCGF2P352271, 2, 3, ENSP000003540334EBI-752313,EBI-2129767 MINT-8010390 MINT-8001946 I2D: score=1 STRING: ENSP00000354033
    USP11P517842, 3MINT-7999769 MINT-7999820 MINT-8010325 MINT-8010390 MINT-8001946 MINT-8012708 MINT-8010231 I2D: score=2 
    USP7Q930092, 3MINT-7999820 MINT-7999745 MINT-8012697 MINT-8010240 MINT-8010390 MINT-8001946 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0016568chromatin modification NAS--
    GO:0016574histone ubiquitination ----
    GO:0035518histone H2A monoubiquitination IDA16943429


    RING1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RING1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RING1

    4 HMDB Compounds for RING1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about RING1 

    Transcripts
    for RING1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RING1 gene: 
    NM_002931.3  

    Unigene Cluster for RING1:

    Ring finger protein 1
    Hs.631989  [show with all ESTs]
    Unigene Representative Sequence: BC002922
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374656(uc011dqw.1 uc011dqx.1 uc003odk.3) ENST00000478431(uc003odl.3)


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    hsa-miR-3149 hsa-miR-3163 hsa-miR-607 hsa-miR-4286 hsa-miR-657 hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: RING1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK289355.1 AK297552.1 AK301010.1 AK301378.1 BC002922.2 BC051866.2 BT007352.1 Z14000.1 

    7 DOTS entries:

    DT.412366  DT.100778150  DT.97843560  DT.95083717  DT.95083723  DT.121359271  DT.121359279 

    24/165 AceView cDNA sequences (see all 165):

    CN482549 BM555805 BM726132 BM468197 CB269896 CF132233 BF880059 BM699973 
    AL576514 BQ066472 CR608675 BF594744 BM669933 CD673971 AU099197 CD724037 
    BQ576052 AI886856 CR624041 BX100281 BC002922 AU104696 BI259576 BM905799 

    GeneLoc Exon Structure


    Expression
    for RING1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RING1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGTATCCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RING1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RING1

    SOURCE GeneReport for Unigene cluster: Hs.631989
        SABiosciences Expression via Pathway-Focused PCR Arrays including RING1: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RING1

    Orthologs
    for RING1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RING1 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ring11 , 5 ring finger protein 11, 5 88.67(n)1
    96.55(a)1    		   17 (17.98 cM)5
    197631  NM_009066.31  NP_033092.31 
     340207925 
    lizard
    (Anolis carolinensis)    		 Reptilia RING16
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL344367.1(29442-41066)
    rainbow trout
    (Oncorhynchus mykiss)    		 Actinopterygii Omy.13102 Oncorhynchus mykiss transcribed sequence with weak more 77.74(n)    BX072591.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ring3   -- 78(a)   98B1   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RING1B6
    ATRING1A6
    		 putative E3 ubiquitin-protein ligase RING1a
    		 14(a)
    12(a)
    		 many ↔ many
    many ↔ many
    		 1(944572-947483)
    5(17835849-17839254)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 zinc finger C3HC4 type family protein, putative
    (see all 4)    		 9(a)
    8(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 11(21100507-21106142)
    11(21350326-21357335)


    ENSEMBL Gene Tree for RING1 (if available)
    TreeFam Gene Tree for RING1 (if available) 

    Paralogs
    for RING1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RING1 gene
    RNF22  
    1 SIMAP similar gene for RING1 using alignment to 1 protein entry:     RING1_HUMAN:
    RNF2

    RING1 for paralogs           About GeneDecksing



    Genomic Variants
    for RING1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 NCBI SNPs in RING1 are shown (see all 100)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1996114051,2
    		--33174411(+) CCCTCC/GCAGGA 3 -- us2k1 int10--------
    rs2015460421,2
    		--33174441(+) CTCAAA/GGACCC 3 -- us2k1 ut310--------
    rs2002476141,2
    		--33174459(+) GCTCA-/CCCCCC 3 -- us2k1 ut310--------
    rs2016941731,2
    		--33174462(+) TCACCC/TCCCCA 3 -- us2k1 ut310--------
    rs1887721521,2
    		--33174613(+) ACCTCC/TGGCTC 3 -- us2k1 ds50010--------
    rs4214461,2
    		C,F,A,H,--33174783(-) TCCCTT/CCAAAA 3 -- us2k1 ds5001 trp325Minor allele frequency- C:0.44MN NS EA NA WA CSA 3112
    rs1149384921,2
    		C,F,--33174830(+) GCACCA/GGTCCC 3 -- us2k1 ds50011Minor allele frequency- G:0.05WA 118
    rs1413392301,2
    		--33175168(+) ATAAGC/GACTGG 2 -- us2k10--------
    rs1508072621,2
    		--33175496(+) CCTGTA/GTACCC 2 -- us2k10--------
    rs1078221,2
    		C,F,A,H,--33175575(-) GGAATG/AGAGAC 2 -- us2k124Minor allele frequency- A:0.50MN NS EA WA CSA NA 4612

    HapMap Linkage Disequilibrium report for RING1 (33176272 - 33180499 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RING1: --

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    Disorders / Diseases
    for RING1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RING1 for disorders           About GeneDecksing

    OMIM gene information: 602045    OMIM disorders: --

    17 diseases for RING1:    About MalaCards
    partial central choroid dystrophy    occult macular dystrophy    b-cell lymphomas    systemic lupus erythematosus
    lupus erythematosus    synovial sarcoma    macular dystrophy    choroidal dystrophy
    renal cell carcinoma    hodgkin's lymphoma    myelodysplastic syndrome    sarcoma
    choroiditis    breast carcinoma    carcinoma    prostate cancer
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for RING1:
    Adenoiditis     Occult macular dystrophy

    4 Novoseek disease relationships for RING1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 38.7 1 15470680 (1)
    tumors 8.71 9 16528373 (3), 18984978 (2), 14742259 (1)
    carcinoma 7.2 6 18984978 (4), 16528373 (2)
    lymphoma 4.7 1 14742259 (1)

    Human Genome Epidemiology (HuGE) Navigator: RING1 (9 documents)

    Export disorders for RING1 gene to outside databases

    Publications
    for RING1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RING1 gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with RING1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity. (PubMed id 9858531)1, 2, 9 Satijn D.P.E. and Otte A.P. (1999)
    2. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. (PubMed id 9199346)1, 2, 9 Satijn D.P.E.... Otte A.P. (1997)
    3. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2, 9 Gearhart M.D.... Bardwell V.J. (2006)
    4. Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N....Peters G. (2009)
    5. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    6. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)1, 2 Levine S.S....Kingston R.E. (2002)
    10. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2 Ogawa H.... Nakatani Y. (2002)

    External Searches for RING1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RING1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6015 HGNC: 10018 AceView: RING1 Ensembl:ENSG00000204227 euGenes: HUgn6015
    ECgene: RING1 H-InvDB: RING1

    Other Databases showing RING1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RING1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RING1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RING1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RING1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RING1 gene:
    Search GeneIP for patents involving RING1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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