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RING1 Gene

protein-coding   GIFtS: 64
GCID: GC06P033202

Ring Finger Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 11 2 3     RING1A2
RNF12 3 5     E3 Ubiquitin-Protein Ligase RING12
Polycomb Complex Protein RING12 3     EC 6.3.2.-3
Really Interesting New Gene 1 Protein2 3     EC 6.3.28

External Ids:    HGNC: 100181   Entrez Gene: 60152   Ensembl: ENSG000002042277   OMIM: 6020455   UniProtKB: Q065873   

Export aliases for RING1 gene to outside databases

Previous GC identifers: GC06P033179 GC06P033169 GC06P033223 GC06P033284 GC06P033177 GC06P032920 GC06P033187 GC06P033196


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RING1 Gene:
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a
zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a
transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product
interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large
nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the
HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. (provided by RefSeq, Jul
2008)

GeneCards Summary for RING1 Gene:
RING1 (ring finger protein 1) is a protein-coding gene. Diseases associated with RING1 include occult macular dystrophy, and embryonal cancer. GO annotations related to this gene include ubiquitin-protein ligase activity and chromatin binding. An important paralog of this gene is RNF2.

UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
Function: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of
histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination
gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of
female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class
required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout
development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin
heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase
activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity

Gene Wiki entry for RING1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RING1 gene promoter:
         Sp1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RING1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RING1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

RING1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RING1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033202:  view genomic region     (about GC identifiers)

Start:
33,176,272 bp from pter      End:
33,180,499 bp from pter
Size:
4,228 bases      Orientation:
plus strand

5 alternative locations:
Chr6+,NT_167245 4,457,593-4,461,806      Chr6+,NT_113891.2 4,620,116-4,624,329      Chr6+,NT_167246 4,633,606-4,637,819     
Chr6+,NT_167248 4,408,513-4,412,726      Chr6+,NT_167247 4,650,047-4,654,260     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RING1  
Size: 406 amino acids; 42429 Da
Subunit: Component of chromatin-associated Polycomb (PcG) complexes. Interacts with BMI1 (By similarity). Part of
the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2/RING2
MBLR, L3MBTL2 and YAF2. Interacts with CBX2 and PCGF6. Component of a PRC1-like complex. Component of repressive
BCOR complex containing Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RNF2/RING2.
Interacts with PCGF2, RNF2; CBX6, CBX7 and CBX8. Interacts with PHC2 (By similarity)
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of
different PRC1-like complexes
Secondary accessions: A8JZZ0 Q5JP96 Q5SQW2 Q86V19
Alternative splicing: 2 isoforms:  Q06587-1   Q06587-2   

Explore the universe of human proteins at neXtProt for RING1: NX_Q06587

Explore proteomics data for RING1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12, Lys275, Lys297
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RING1 (Q06587) (see all 14)
     EIELVFR  QTRYVKTT  SEKQYTIYI  LISKIYPSR 


    See RING1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002922.2  
    ENSEMBL proteins: 
     ENSP00000363787  
    Reactome Protein details: Q06587

    RING1 Human Recombinant Protein Products:

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    Novus Biologicals RING1 Proteins
    Novus Biologicals RING1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    RING1 Antibody Products:

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    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RING1 
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    RING1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RING1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR018957 Znf_C3HC4_RING-type

    Graphical View of Domain Structure for InterPro Entry Q06587

    ProtoNet protein and cluster: Q06587

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
    Similarity: Contains 1 RING-type zinc finger


    RING1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RING1_HUMAN, Q06587
    Function: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of
    histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination
    gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of
    female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class
    required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout
    development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin
    heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase
    activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI15386022
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RING1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RING1:
     Cell cycle / mitosis defect  Increased circadian period len  Synthetic lethal with c-Myc af 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ring1):
     skeleton 

    RING1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ring1tm1Mvi for RING1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RING1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RING1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RING1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RING1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RING1:
    hsa-mir-155-5p (MIRT020727), hsa-mir-484 (MIRT042052)

    Block miRNA regulation of human, mouse, rat RING1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RING1 (see all 14):
    hsa-miR-3149 hsa-miR-3163 hsa-miR-607 hsa-miR-4286 hsa-miR-657 hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidRING1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RING1
    Predesigned siRNA for gene silencing in human, mouse, rat RING1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RING1

    Clone
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    OriGene clones in human, mouse for RING1 (see all 6)
    OriGene ORF clones in mouse, rat for RING1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RING1 (NM_002931)
    Sino Biological Human cDNA Clone for RING1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RING1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RING1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RING1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RING1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RING1_HUMAN, Q06587: Nucleus. Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ----
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    RING1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RING1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    2Notch signaling pathway (KEGG)
    Delta-Notch Signaling Pathway0.33
    3Packaging Of Telomere Ends
    Histone modification0.31
    4Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    5Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for RING1
        Chromatin Regulation / Acetylation
    Wnt / Hedgehog / Notch
    Protein Stability

    1 BioSystems Pathway for RING1
        Delta-Notch Signaling Pathway


    1 Reactome Pathway for RING1
        Oxidative Stress Induced Senescence


    UniProtKB/Swiss-Prot: RING1_HUMAN, Q06587
    Pathway: Protein modification; protein ubiquitination


    RING1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RING1: 

              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RING1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RING1 (Q065871, 2, 3 ENSP000003637874) via UniProtKB, MINT, STRING, and/or I2D (see all 660)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP11P517841, 2, 3EBI-752313,EBI-306876 MINT-7999769 MINT-7999820 MINT-8010325 MINT-8010390 MINT-8001946 MINT-8012708 MINT-8010231 I2D: score=2 
    USP7Q930091, 2, 3EBI-752313,EBI-302474 MINT-7999820 MINT-7999745 MINT-8012697 MINT-8010240 MINT-8010390 MINT-8001946 I2D: score=2 
    RNF2Q994961, 2, 3, ENSP000003564804EBI-752313,EBI-722416 MINT-7945693 MINT-8010325 MINT-8010390 I2D: score=5 STRING: ENSP00000356480
    CBX8Q9HC521, 2, 3, ENSP000002693854EBI-752313,EBI-712912 MINT-8010325 MINT-8010390 MINT-8001946 I2D: score=3 STRING: ENSP00000269385
    PCGF2P352271, 2, 3, ENSP000003540334EBI-752313,EBI-2129767 MINT-8010390 MINT-8001946 I2D: score=1 STRING: ENSP00000354033
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0016568chromatin modification ----
    GO:0016574histone ubiquitination ----
    GO:0035518histone H2A monoubiquitination IDA16943429

    RING1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RING1

    4 HMDB Compounds for RING1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RING1 gene: 
    NM_002931.3  

    Unigene Cluster for RING1:

    Ring finger protein 1
    Hs.631989  [show with all ESTs]
    Unigene Representative Sequence: BC002922
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374656(uc011dqw.1 uc011dqx.1 uc003odk.3) ENST00000478431(uc003odl.3)

    miRNA
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    hsa-miR-3149 hsa-miR-3163 hsa-miR-607 hsa-miR-4286 hsa-miR-657 hsa-miR-583 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidRING1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RING1 (NM_002931)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RING1
      QuantiTect SYBR Green Assays in human, mouse, rat RING1
      QuantiFast Probe-based Assays in human, mouse, rat RING1

    Additional mRNA sequence: 

    AK289355.1 AK297552.1 AK301010.1 AK301378.1 BC002922.2 BC051866.2 BT007352.1 Z14000.1 

    7 DOTS entries:

    DT.412366  DT.100778150  DT.97843560  DT.95083717  DT.95083723  DT.121359271  DT.121359279 

    Selected AceView cDNA sequences (see all 165):

    CB269896 BM699973 AU099197 CR598354 AW207576 AA227525 AI886856 BQ066472 
    CD673754 CR608675 CF132233 BQ637475 CR624041 BM905799 AL553543 BC051866 
    BM468197 BU072329 BI908805 CR606762 BF594744 NM_002931 CD673971 BM726132 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RING1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTATCCCT
    RING1 Expression
    About this image

    RING1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RING1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631989
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RING1: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RING1
    OriGene qSTAR qPCR primer pairs in human, mouse for RING1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RING1
    QuantiTect SYBR Green Assays in human, mouse, rat RING1
    QuantiFast Probe-based Assays in human, mouse, rat RING1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RING1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RING1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ring11 , 5 ring finger protein 11, 5 88.67(n)1
    96.55(a)1
      17 (17.98 cM)5
    197631  NM_009066.31  NP_033092.31 
     340207925 
    lizard
    (Anolis carolinensis)
    Reptilia RING16
    ring finger protein 1
    71(a)
    1 ↔ 1
    GL344367.1(29442-41888)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ring11 ring finger protein 1 65.89(n)
    74.27(a)
      100037886  NM_001097325.1  NP_001090794.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.13102 Oncorhynchus mykiss transcribed sequence with weak more 77.74(n)    BX072591.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ring3   -- 78(a)   98B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea spat-36
    Protein SPAT-3, isoform a
    2(a)
    1 → many
    X(4595997-4605930) WBGene00020496


    ENSEMBL Gene Tree for RING1 (if available)
    TreeFam Gene Tree for RING1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RING1 gene
    RNF22  
    1 SIMAP similar gene for RING1 using alignment to 1 protein entry:     RING1_HUMAN:
    RNF2

    RING1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RING1 (see all 127)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1471963931,2
    C--33176458(+) CGGGGA/GCGGAG 1 -- int10--------
    rs1870137581,2
    --33176710(+) ACCCCC/GTCCCC 1 -- int10--------
    rs1147590121,2
    C,F--33176749(+) CACAGC/TTTCTT 1 -- int11Minor allele frequency- T:0.14WA 118
    rs1902012731,2
    --33176895(+) TCATTG/TGAAAG 1 -- int10--------
    rs1152016241,2
    C,F--33176937(+) CTCATT/CCAGTG 1 -- int12Minor allele frequency- C:0.03WA NA 238
    rs2132091,2
    C,F,A,H--33176958(-) CTTATG/ATGCAC 1 -- int128Minor allele frequency- A:0.43EA NA MN NS WA CSA 3168
    rs1407729541,2
    --33177123(+) TTTTTC/TCCAAC 1 -- int10--------
    rs1148877731,2
    C,F--33177160(+) AGGCCA/GCTTAG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs92960891,2
    C,F,H--33177341(+) GGGCTG/ACTGTT 1 -- int1 ese33Minor allele frequency- A:0.01NS NA 274
    rs1825940081,2
    C--33177650(+) TCAGTA/TCCCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RING1 (33176272 - 33180499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RING1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885768CNV Loss21882294
    nsv830634CNV Loss17160897
    nsv522719CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RING1
    DNA2.0 Custom Variant and Variant Library Synthesis for RING1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602045    OMIM disorders: --

    18 diseases for RING1:    
    About MalaCards
    occult macular dystrophy    embryonal cancer    partial central choroid dystrophy    macular dystrophy
    choroiditis    synovial sarcoma    adenoiditis    myelodysplastic syndromes
    b-cell lymphomas    hodgkin's lymphoma    type 1 diabetes    mental retardation
    systemic lupus erythematosus    sarcoma    lupus erythematosus    renal cell carcinoma
    prostate cancer    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for RING1:
    Adenoiditis     Occult macular dystrophy

    RING1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for RING1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 38.7 1 15470680 (1)
    tumors 8.71 9 16528373 (3), 18984978 (2), 14742259 (1)
    carcinoma 7.2 6 18984978 (4), 16528373 (2)
    lymphoma 4.7 1 14742259 (1)

    Genetic Association Database (GAD): RING1
    Human Genome Epidemiology (HuGE) Navigator: RING1 (9 documents)

    Export disorders for RING1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RING1 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with RING1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity. (PubMed id 9858531)1, 2, 9 Satijn D.P.E. and Otte A.P. (Mol. Cell. Biol. 1999)
    2. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. (PubMed id 9199346)1, 2, 9 Satijn D.P.E.... Otte A.P. (Mol. Cell. Biol. 1997)
    3. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. (PubMed id 16943429)1, 2, 9 Gearhart M.D.... Bardwell V.J. (Mol. Cell. Biol. 2006)
    4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N.... Peters G. (PLoS ONE 2009)
    8. Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B. (PubMed id 18830248)1, 4 Eike M.C....Lie B.A. (Genes Immun. 2009)
    9. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    10. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4 Horikawa Y....Wu X. (Clin. Cancer Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6015 HGNC: 10018 AceView: RING1 Ensembl:ENSG00000204227 euGenes: HUgn6015
    ECgene: RING1 H-InvDB: RING1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RING1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RING1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RING1 gene:
    Search GeneIP for patents involving RING1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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