External Ids for RIN3 Gene
Previous GeneCards Identifiers for RIN3 Gene
Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for RIN3 Gene
RIN3 (Ras And Rab Interactor 3) is a Protein Coding gene. Diseases associated with RIN3 include Paget's Disease Of Bone. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Vesicle-mediated transport. GO annotations related to this gene include GTPase activator activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIN2.
UniProtKB/Swiss-Prot for RIN3 Gene
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.