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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIN3 Gene

protein-coding   GIFtS: 51
GCID: GC14P092980

Ras And Rab Interactor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras And Rab Interactor 31 2
Ras Interaction/Interference Protein 32 3
RAB5 Interacting Protein 32

External Ids:    HGNC: 187511   Entrez Gene: 798902   Ensembl: ENSG000001005997   OMIM: 6102235   UniProtKB: Q8TB243   

Export aliases for RIN3 gene to outside databases

Previous GC identifers: GC14P090625 GC14P086798 GC14P090970 GC14P091012 GC14P092049 GC14P073162


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIN3 Gene:
RIN3 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the
RAB5 small GTPases (see RAB5A; MIM 179512) (Kajiho et al., 2003 (PubMed 12972505)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RIN3 Gene: 
RIN3 (Ras and Rab interactor 3) is a protein-coding gene. Diseases associated with RIN3 include cardiac tamponade, and paget's disease of bone. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity and GTPase activator activity. An important paralog of this gene is RIN2.

UniProtKB/Swiss-Prot: RIN3_HUMAN, Q8TB24
Function: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by
exchanging bound GDP for free GTP. Required for normal RAB31 function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIN3 gene promoter:
         TBP   SRF   AML1a   SRF (504 AA)   E47   C/EBPalpha   CHOP-10   TFIID   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.13

RIN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIN3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P092980:  view genomic region     (about GC identifiers)

Start:
92,980,118 bp from pter      End:
93,155,339 bp from pter
Size:
175,222 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIN3_HUMAN, Q8TB24 (See protein sequence)
Recommended Name: Ras and Rab interactor 3  
Size: 985 amino acids; 107854 Da
Subunit: Interacts with CD2AP, RAB5B, RAB31 and BIN1
Subcellular location: Cytoplasm. Cytoplasmic vesicle. Early endosome. Note=Activation of tyrosine phosphorylation
signaling induces translocation to cytoplasmic vesicles
Sequence caution: Sequence=BAB13888.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=BAB15357.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC03432.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
1 PDB 3D structure from and Proteopedia for RIN3:
3U23 (3D)    
Secondary accessions: Q76LB3 Q8NF30 Q8TEE8 Q8WYP4 Q9H6A5 Q9HAG1
Alternative splicing: 2 isoforms:  Q8TB24-1   Q8TB24-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIN3: NX_Q8TB24

Explore proteomics data for RIN3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TB24

  • RIN3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIN3 Protein Expression
    REFSEQ proteins: NP_079108.3  
    ENSEMBL proteins: 
     ENSP00000216487   ENSP00000450682   ENSP00000452155   ENSP00000450986  

    Human Recombinant Protein Products for RIN3: 
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    Novus Biologicals RIN3 Protein
    Novus Biologicals RIN3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIN3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0031410cytoplasmic vesicle IDA--

    RIN3 for ontologies           About GeneDecksing



    RIN3 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for RIN3 

    Assay Products for RIN3: 
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    Cloud-Clone Corp. CLIAs for RIN3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013995 VPS9_subgr
     IPR003123 VPS9
     IPR000159 Ras-assoc
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q8TB24

    ProtoNet protein and cluster: Q8TB24

    2 Blocks protein domains:
    IPB000159 RA domain
    IPB003123 Vacuolar sorting protein 9


    UniProtKB/Swiss-Prot: RIN3_HUMAN, Q8TB24
    Similarity: Belongs to the RIN (Ras interaction/interference) family
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 VPS9 domain


    RIN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIN3_HUMAN, Q8TB24
    Function: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by
    exchanging bound GDP for free GTP. Required for normal RAB31 function

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI17474147
    GO:0017112Rab guanyl-nucleotide exchange factor activity IMP--
    GO:0017137Rab GTPase binding IDA--
         
    RIN3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIN3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIN3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIN3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIN3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIN3
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RIN3:
    hsa-miR-4324 hsa-miR-623 hsa-miR-2110 hsa-miR-211 hsa-miR-3158-3p hsa-miR-204 hsa-miR-3119 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidRIN3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIN3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for RIN3 (Q8TB241, 2, 3 ENSP000002164874) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 2, 3, ENSP000002440074EBI-1570523,EBI-79387 MINT-8112711 I2D: score=3 STRING: ENSP00000244007
    BIN1O004992, 3, ENSP000003167794MINT-58368 MINT-62883 MINT-58365 MINT-58369 I2D: score=3 STRING: ENSP00000316779
    ABL1P005192, 3, ENSP000003614234MINT-8110707 I2D: score=3 STRING: ENSP00000361423
    RGS2P412202, 3MINT-8268933 I2D: score=2 
    RABAC1Q9UI142, 3, ENSP000002220084MINT-8267819 I2D: score=2 STRING: ENSP00000222008
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis NAS11733506
    GO:0007165signal transduction IEA--

    RIN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIN3

    3 HMDB Compounds for RIN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RIN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIN3 gene: 
    NM_024832.3  

    Unigene Cluster for RIN3:

    Ras and Rab interactor 3
    Hs.326822  [show with all ESTs]
    Unigene Representative Sequence: AK090451
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216487(uc001yap.3 uc010auk.3) ENST00000555589(uc001yar.1 uc001yas.1)
    ENST00000557762 ENST00000556385 ENST00000418924(uc001yaq.3) ENST00000555908
    ENST00000555891 ENST00000554888 ENST00000553992 ENST00000556418 ENST00000553959

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate RIN3:
    hsa-miR-4324 hsa-miR-623 hsa-miR-2110 hsa-miR-211 hsa-miR-3158-3p hsa-miR-204 hsa-miR-3119 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidRIN3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RIN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIN3
    Clone
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    OriGene clones in human, mouse for RIN3 (see all 8)
    OriGene ORF clones in mouse, rat for RIN3
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    GenScript: all cDNA clones in your preferred vector: RIN3 (NM_024832)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIN3
    Sirion Biotech Customized lentivirus for stable overexpression of RIN3 
                         Customized lentivirus expression plasmids for stable overexpression of RIN3 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RIN3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIN3

    Additional mRNA sequence: 

    AB060338.1 AB081753.1 AK021762.1 AK026092.1 AK074176.1 AK090451.1 AK128338.1 BC025248.1 
    BC032614.1 BC070062.1 BX248258.1 CR936654.1 

    13 DOTS entries:

    DT.311715  DT.99965078  DT.97768445  DT.95200654  DT.100785497  DT.95159544  DT.75123114  DT.99936067 
    DT.75160465  DT.92070469  DT.95115348  DT.100704334  DT.100840621 

    24/155 AceView cDNA sequences (see all 155):

    AB081753 AI027923 AB060338 AI760894 AI523920 CD671502 BF512111 AI365464 
    CR620663 AL832844 AI871161 BX432875 BX114830 BE646425 BU164512 BF431888 
    BF940697 BQ922056 BM923082 AW206171 CA445108 AW027923 BE675211 BF430921 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RIN3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
    SP1:                                            -                                                               
    SP2:                                                                                                  -         
    SP3:                                                                                                            
    SP4:                                -                                                                           
    SP5:                    -     -     -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for RIN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGCCCA
    RIN3 Expression
    About this image


    See RIN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIN3

    SOURCE GeneReport for Unigene cluster: Hs.326822

    UniProtKB/Swiss-Prot: RIN3_HUMAN, Q8TB24
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for RIN3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RIN3 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rin31 , 5 Ras and Rab interactor 31, 5 81.2(n)1
    78.31(a)1
      12 (51.45 cM)5
    2178351  NM_177620.41  NP_808288.21 
     1022830485 
    chicken
    (Gallus gallus)
    Aves RIN31 Ras and Rab interactor 3 62.97(n)
    59.71(a)
      423417  XM_421327.3  XP_421327.3 
    lizard
    (Anolis carolinensis)
    Reptilia RIN36
    Uncharacterized protein
    56(a)
    1 ↔ 1
    1(11297491-11353290)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.73712 Transcribed sequence with weak similarity to protein more 78.35(n)    AL859062.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fk30a051 wu:fk30a05 55.72(n)
    49.77(a)
      799244  XM_001339586.4  XP_001339622.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta spri6
    sprint
    9(a)
    1 → many
    X(10384102-10479455)
    worm
    (Caenorhabditis elegans)
    Secernentea rin-16
    Protein TAG-333, isoform f
    9(a)
    1 → many
    V(14784152-14815600)


    ENSEMBL Gene Tree for RIN3 (if available)
    TreeFam Gene Tree for RIN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIN3 gene
    RIN22  RIN12  RINL2  
    2 SIMAP similar genes for RIN3 using alignment to 5 protein entries:     RIN3_HUMAN (see all proteins):
    DKFZp762H1613    RIN2

    RIN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4071 SNPs in RIN3 are shown (see all 4071)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017829941,2
    --92978163(+) CCCTT-/AAAAAA 1 -- us2k10--------
    rs1405146031,2
    C--92978298(+) TTTTCA/GTCACC 1 -- us2k10--------
    rs619773381,2
    C,F--92978386(+) TCTGGA/GCTTGC 1 -- us2k13Minor allele frequency- G:0.06NA 124
    rs49049481,2
    C,A,H--92978404(+) GGACAT/CTTCAT 1 -- us2k111Minor allele frequency- C:0.27NA WA CSA EA 375
    rs1831374651,2
    --92978599(+) TTTTGA/GCTAGT 1 -- us2k10--------
    rs749552651,2
    C,F--92978621(+) TACTCT/CTTATA 1 -- us2k12Minor allele frequency- C:0.07NA EA 240
    rs1379996691,2
    --92978671(+) AACTT-/ATAC  
            
    ATGAA
    1 -- us2k10--------
    rs80106961,2
    C,F--92979009(+) gtcctG/Ctctgg 1 -- us2k12Minor allele frequency- C:0.11WA 120
    rs1884241161,2
    --92979116(+) GCCCCC/TGGAGG 1 -- us2k10--------
    rs746889481,2
    C,F--92979197(+) CATGGA/CGAGGC 1 -- us2k11Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for RIN3 (92980118 - 93155339 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for RIN3 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676688CNV Deletion23128226
    esv2749024CNV Deletion23290073
    esv1248112CNV Deletion17803354
    esv1485745CNV Insertion17803354
    nsv1399CNV Insertion18451855
    esv1630206CNV Insertion17803354
    nsv509544CNV Insertion20534489
    esv1499156CNV Insertion17803354
    nsv513417CNV Insertion21212237
    nsv456399CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610223    OMIM disorders: --

    2 diseases for RIN3:    About MalaCards
    cardiac tamponade    paget's disease of bone


    RIN3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RIN3
    Human Genome Epidemiology (HuGE) Navigator: RIN3 (1 document)

    Export disorders for RIN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIN3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with RIN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PubMed id 11733506)1, 2, 3 Saito K.... Katada T. (2002)
    2. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. (PubMed id 12972505)1, 2, 9 Kajiho H....Katada T. (2003)
    3. Genome-wide association identifies three new suscepti bility loci for Paget's disease of bone. (PubMed id 21623375)1, 4 Albagha O.M....Ralston S.H. (2011)
    4. Characterization of RIN3 as a guanine nucleotide exch ange factor for the Rab5 subfamily GTPase Rab31. (PubMed id 21586568)1, 2 Kajiho H....Katada T. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles. (PubMed id 18486601)1, 2 Yoshikawa M....Katada T. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    10. TNFAIP1 interacts with KCTD10 to promote the degradati on of KCTD10 proteins and inhibit the transcriptional activities of NF-kB and AP -1. (PubMed id 22810651)1 Hu X....Zhang J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79890 HGNC: 18751 AceView: RIN3 Ensembl:ENSG00000100599 euGenes: HUgn79890
    ECgene: RIN3 H-InvDB: RIN3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIN3 gene:
    Search GeneIP for patents involving RIN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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