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Aliases for RIN3 Gene

Aliases for RIN3 Gene

  • Ras And Rab Interactor 3 2 3 5
  • Ras Interaction/Interference Protein 3 4

External Ids for RIN3 Gene

Previous GeneCards Identifiers for RIN3 Gene

  • GC14P090625
  • GC14P086798
  • GC14P090970
  • GC14P091012
  • GC14P092049
  • GC14P092980
  • GC14P073162

Summaries for RIN3 Gene

Entrez Gene Summary for RIN3 Gene

  • Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for RIN3 Gene

RIN3 (Ras And Rab Interactor 3) is a Protein Coding gene. Diseases associated with RIN3 include Paget's Disease Of Bone. GO annotations related to this gene include GTPase activator activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RINL.

UniProtKB/Swiss-Prot for RIN3 Gene

  • Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIN3 Gene

Genomics for RIN3 Gene

Regulatory Elements for RIN3 Gene

Enhancers for RIN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RIN3 on UCSC Golden Path with GeneCards custom track

Promoters for RIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RIN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIN3 Gene

92,513,774 bp from pter
92,688,994 bp from pter
175,221 bases
Plus strand

Genomic View for RIN3 Gene

Genes around RIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIN3 Gene

Proteins for RIN3 Gene

  • Protein details for RIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras and Rab interactor 3
    Protein Accession:
    Secondary Accessions:
    • Q76LB3
    • Q8NF30
    • Q8TEE8
    • Q8WYP4
    • Q9H6A5
    • Q9HAG1

    Protein attributes for RIN3 Gene

    985 amino acids
    Molecular mass:
    107854 Da
    Quaternary structure:
    • Interacts with CD2AP, RAB5B, RAB31 and BIN1.
    • Sequence=BAB13888.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAB15357.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03432.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIN3 Gene

    Alternative splice isoforms for RIN3 Gene


neXtProt entry for RIN3 Gene

Proteomics data for RIN3 Gene at MOPED

Post-translational modifications for RIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIN3 Gene

No data available for DME Specific Peptides for RIN3 Gene

Domains & Families for RIN3 Gene

Gene Families for RIN3 Gene

Protein Domains for RIN3 Gene

Suggested Antigen Peptide Sequences for RIN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-associating domain.
  • Belongs to the RIN (Ras interaction/interference) family.
  • Contains 1 Ras-associating domain.
  • Contains 1 SH2 domain.
  • Contains 1 VPS9 domain.
  • Belongs to the RIN (Ras interaction/interference) family.
genes like me logo Genes that share domains with RIN3: view

Function for RIN3 Gene

Molecular function for RIN3 Gene

UniProtKB/Swiss-Prot Function:
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

Gene Ontology (GO) - Molecular Function for RIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017112 Rab guanyl-nucleotide exchange factor activity IMP 21586568
genes like me logo Genes that share ontologies with RIN3: view
genes like me logo Genes that share phenotypes with RIN3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIN3 Gene

Localization for RIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIN3 Gene

Cytoplasm. Cytoplasmic vesicle. Early endosome. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. {ECO:0000269 PubMed:18486601}.

Subcellular locations from

Jensen Localization Image for RIN3 Gene COMPARTMENTS Subcellular localization image for RIN3 gene
Compartment Confidence
endosome 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for RIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 21586568
genes like me logo Genes that share ontologies with RIN3: view

Pathways & Interactions for RIN3 Gene

SuperPathways for RIN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIN3 Gene


No data available for Pathways by source and SIGNOR curated interactions for RIN3 Gene

Drugs & Compounds for RIN3 Gene

(3) Drugs for RIN3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIN3: view

Transcripts for RIN3 Gene

Unigene Clusters for RIN3 Gene

Ras and Rab interactor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: -
SP2: -
SP4: -
SP5: - - - - - - - -

Relevant External Links for RIN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIN3 Gene

mRNA expression in normal human tissues for RIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIN3 Gene

This gene is overexpressed in Whole Blood (x20.1).

Protein differential expression in normal tissues from HIPED for RIN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), Monocytes (11.8), NK cells (10.0), Blymphocyte (6.3), and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RIN3 Gene

SOURCE GeneReport for Unigene cluster for RIN3 Gene Hs.326822

mRNA Expression by UniProt/SwissProt for RIN3 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RIN3: view

Protein tissue co-expression partners for RIN3 Gene

- Elite partner

Primer Products

Orthologs for RIN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rin3 35
  • 80.92 (n)
  • 77.89 (a)
Rin3 16
Rin3 36
  • 77 (a)
(Pan troglodytes)
Mammalia RIN3 35
  • 98.81 (n)
  • 98.67 (a)
RIN3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rin3 35
  • 80.74 (n)
  • 79.57 (a)
(Bos Taurus)
Mammalia RIN3 36
  • 74 (a)
(Canis familiaris)
Mammalia RIN3 36
  • 75 (a)
(Monodelphis domestica)
Mammalia RIN3 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
-- 36
  • 82 (a)
(Gallus gallus)
Aves RIN3 35
  • 63.22 (n)
  • 60.22 (a)
RIN3 36
  • 56 (a)
(Anolis carolinensis)
Reptilia RIN3 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rin3 35
  • 64.59 (n)
  • 62.15 (a)
Str.7371 35
(Danio rerio)
Actinopterygii RIN3 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta spri 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea rin-1 36
  • 11 (a)
Species with no ortholog for RIN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIN3 Gene

Gene Tree for RIN3 (if available)
Gene Tree for RIN3 (if available)

Paralogs for RIN3 Gene

Paralogs for RIN3 Gene

(2) SIMAP similar genes for RIN3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RIN3: view

Variants for RIN3 Gene

Sequence variations from dbSNP and Humsavar for RIN3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2274542 - 92,577,441(+) CGGCC(A/G)AGGTG reference, missense, utr-variant-5-prime
rs3829947 -, -, - 92,651,693(-) CGTCA(A/C/G/T)GGGCT reference, missense, utr-variant-5-prime
rs3742717 -, - 92,652,323(-) GGGGC(A/G)TGTCC reference, missense
rs12434929 - 92,652,887(+) CAAGG(A/C/G)CTCGT reference, missense
rs7140450 -- 92,611,821(+) AATTT(A/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIN3 Gene

Variant ID Type Subtype PubMed ID
nsv832860 CNV Gain 17160897
esv275342 CNV Loss 21479260
nsv509544 CNV Insertion 20534489
nsv513417 CNV Insertion 21212237
esv1630206 CNV Insertion 17803354
esv1499156 CNV Insertion 17803354
esv1485745 CNV Insertion 17803354
esv2676688 CNV Deletion 23128226
esv23961 CNV Gain 19812545
esv2749024 CNV Deletion 23290073
esv1248112 CNV Deletion 17803354
nsv522954 CNV Loss 19592680
nsv1399 CNV Insertion 18451855
nsv456399 CNV Loss 19166990
nsv827027 CNV Gain 20364138

Variation tolerance for RIN3 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.37; 96.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RIN3 Gene

Disorders for RIN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RIN3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paget's disease of bone
  • familial paget's disease of bone
- elite association - COSMIC cancer census association via MalaCards
Search RIN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RIN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RIN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIN3 Gene

Publications for RIN3 Gene

  1. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PMID: 11733506) Saito K. … Katada T. (J. Biol. Chem. 2002) 2 3 4 67
  2. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. (PMID: 12972505) Kajiho H. … Katada T. (J. Cell Sci. 2003) 3 23
  3. IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. (PMID: 25101718) Lee J.H. … Silverman E.K. (Am. J. Respir. Cell Mol. Biol. 2015) 3
  4. Targeted sequencing of the Paget's disease associated 14q32 locus identifies several missense coding variants in RIN3 that predispose to Paget's disease of bone. (PMID: 25701875) Vallet M. … Albagha O.M. (Hum. Mol. Genet. 2015) 3
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3

Products for RIN3 Gene

Sources for RIN3 Gene