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Aliases for RIN3 Gene

Aliases for RIN3 Gene

  • Ras And Rab Interactor 3 2 3 5
  • Ras Interaction/Interference Protein 3 4

External Ids for RIN3 Gene

Previous GeneCards Identifiers for RIN3 Gene

  • GC14P090625
  • GC14P086798
  • GC14P090970
  • GC14P091012
  • GC14P092049
  • GC14P092980
  • GC14P073162

Summaries for RIN3 Gene

Entrez Gene Summary for RIN3 Gene

  • Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for RIN3 Gene

RIN3 (Ras And Rab Interactor 3) is a Protein Coding gene. Diseases associated with RIN3 include Paget's Disease Of Bone. Among its related pathways are Vesicle-mediated transport. GO annotations related to this gene include GTPase activator activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIN2.

UniProtKB/Swiss-Prot for RIN3 Gene

  • Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIN3 Gene

Genomics for RIN3 Gene

Regulatory Elements for RIN3 Gene

Enhancers for RIN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F092643 1.5 FANTOM5 ENCODE 25.8 +139.5 139513 18.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 GATA2 RIN3 TRIP11 SLC24A4 ITPK1 GC14P092700 PIR35810
GH14F092581 1.5 FANTOM5 Ensembl ENCODE 21.7 +71.2 71191 7.5 HDGF TBL1XR1 WRNIP1 BMI1 RAD21 ZBTB40 EGR1 SCRT2 ZNF143 ETV6 RIN3 SLC24A4 ATXN3 PIR35810 GC14P092700
GH14F092469 1.5 FANTOM5 Ensembl ENCODE 19.6 -40.6 -40608 6.5 ELF3 SIN3A THRB ZNF48 RAD21 RARA EGR2 CEBPB REST ZNF592 RIN3 SLC24A4 TRIP11 ATXN3 GC14P092498 GC14P092353
GH14F092567 1.6 FANTOM5 Ensembl ENCODE 16.2 +55.8 55797 3.8 HDGF ATF1 MLX ARID4B SIN3A DMAP1 GLIS2 ZNF143 ZNF207 FOS RIN3 PIR35810 LOC105370707
GH14F092458 1.4 FANTOM5 Ensembl ENCODE 16.6 -52.6 -52573 4.8 CTCF PKNOX1 JUN ZMYM3 SIN3A RELA CTBP1 GATA3 ZFHX2 ETV6 RIN3 SLC24A4 ATXN3 GC14P092498 GC14P092353
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIN3 on UCSC Golden Path with GeneCards custom track

Promoters for RIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000422711 426 2401 ELF3 CBX3 ARID4B SIN3A DMAP1 ZNF48 RAD21 DNMT3B ZBTB40 RARA

Genomic Location for RIN3 Gene

92,513,774 bp from pter
92,688,994 bp from pter
175,221 bases
Plus strand

Genomic View for RIN3 Gene

Genes around RIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIN3 Gene

Proteins for RIN3 Gene

  • Protein details for RIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras and Rab interactor 3
    Protein Accession:
    Secondary Accessions:
    • Q76LB3
    • Q8NF30
    • Q8TEE8
    • Q8WYP4
    • Q9H6A5
    • Q9HAG1

    Protein attributes for RIN3 Gene

    985 amino acids
    Molecular mass:
    107854 Da
    Quaternary structure:
    • Interacts with CD2AP, RAB5B, RAB31 and BIN1.
    • Sequence=BAB13888.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAB15357.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03432.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIN3 Gene

    Alternative splice isoforms for RIN3 Gene


neXtProt entry for RIN3 Gene

Post-translational modifications for RIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIN3 Gene

Domains & Families for RIN3 Gene

Gene Families for RIN3 Gene

Protein Domains for RIN3 Gene

Suggested Antigen Peptide Sequences for RIN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ras-associating domain.
  • Belongs to the RIN (Ras interaction/interference) family.
  • Contains 1 Ras-associating domain.
  • Contains 1 SH2 domain.
  • Contains 1 VPS9 domain.
  • Belongs to the RIN (Ras interaction/interference) family.
genes like me logo Genes that share domains with RIN3: view

Function for RIN3 Gene

Molecular function for RIN3 Gene

UniProtKB/Swiss-Prot Function:
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

Gene Ontology (GO) - Molecular Function for RIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 17474147
GO:0017112 Rab guanyl-nucleotide exchange factor activity IMP 21586568
GO:0017137 Rab GTPase binding IDA 21586568
genes like me logo Genes that share ontologies with RIN3: view
genes like me logo Genes that share phenotypes with RIN3: view

Animal Models for RIN3 Gene

MGI Knock Outs for RIN3:
  • Rin3 tm1.1(KOMP)Vlcg

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIN3 Gene

Localization for RIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIN3 Gene

Cytoplasm. Cytoplasmic vesicle. Early endosome. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. {ECO:0000269 PubMed:18486601}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIN3 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 3

Gene Ontology (GO) - Cellular Components for RIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA,IDA 21586568
GO:0031410 cytoplasmic vesicle IEA,IDA 21586568
genes like me logo Genes that share ontologies with RIN3: view

Pathways & Interactions for RIN3 Gene

genes like me logo Genes that share pathways with RIN3: view

Pathways by source for RIN3 Gene

2 Reactome pathways for RIN3 Gene

Gene Ontology (GO) - Biological Process for RIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis NAS 11733506
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RIN3: view

No data available for SIGNOR curated interactions for RIN3 Gene

Drugs & Compounds for RIN3 Gene

(3) Drugs for RIN3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIN3: view

Transcripts for RIN3 Gene

Unigene Clusters for RIN3 Gene

Ras and Rab interactor 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: -
SP2: -
SP4: -
SP5: - - - - - - - -

Relevant External Links for RIN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RIN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIN3 Gene

This gene is overexpressed in Whole Blood (x20.1).

Protein differential expression in normal tissues from HIPED for RIN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), Monocytes (11.8), NK cells (10.0), Blymphocyte (6.3), and Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RIN3 Gene

Protein tissue co-expression partners for RIN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RIN3 Gene:


SOURCE GeneReport for Unigene cluster for RIN3 Gene:


mRNA Expression by UniProt/SwissProt for RIN3 Gene:

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RIN3: view

Primer Products

Orthologs for RIN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RIN3 34 35
  • 98.81 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
-- 35
  • 56 (a)
(Mus musculus)
Mammalia Rin3 34 16 35
  • 80.92 (n)
(Rattus norvegicus)
Mammalia Rin3 34
  • 80.74 (n)
(Canis familiaris)
Mammalia RIN3 35
  • 75 (a)
(Bos Taurus)
Mammalia RIN3 35
  • 74 (a)
(Monodelphis domestica)
Mammalia RIN3 35
  • 57 (a)
(Gallus gallus)
Aves RIN3 34 35
  • 63.22 (n)
(Anolis carolinensis)
Reptilia RIN3 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rin3 34
  • 64.59 (n)
Str.7371 34
(Danio rerio)
Actinopterygii RIN3 35
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta spri 35
  • 10 (a)
(Caenorhabditis elegans)
Secernentea rin-1 35
  • 11 (a)
Species where no ortholog for RIN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIN3 Gene

Gene Tree for RIN3 (if available)
Gene Tree for RIN3 (if available)

Paralogs for RIN3 Gene

Paralogs for RIN3 Gene

(2) SIMAP similar genes for RIN3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RIN3: view

Variants for RIN3 Gene

Sequence variations from dbSNP and Humsavar for RIN3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10047925 -- 92,665,450(+) ctcgg(C/T)tcact intron-variant
rs10130454 -- 92,561,276(+) ATTGT(A/G)TCTAG intron-variant
rs10130770 -- 92,637,045(+) ctttc(A/G)tggaa intron-variant
rs10131197 -- 92,549,049(+) TACTC(A/G)TGGTG intron-variant
rs10131276 -- 92,549,019(+) TCCCA(C/T)GCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIN3 Gene

Variant ID Type Subtype PubMed ID
esv1248112 CNV deletion 17803354
esv1485745 CNV insertion 17803354
esv1499156 CNV insertion 17803354
esv1630206 CNV insertion 17803354
esv23961 CNV gain 19812545
esv2676688 CNV deletion 23128226
esv2749024 CNV deletion 23290073
esv275342 CNV loss 21479260
esv3635340 CNV gain 21293372
esv3635341 CNV loss 21293372
nsv1040081 CNV gain 25217958
nsv1160201 CNV duplication 26073780
nsv1399 CNV insertion 18451855
nsv456399 CNV loss 19166990
nsv509544 CNV insertion 20534489
nsv513417 CNV insertion 21212237
nsv522954 CNV loss 19592680
nsv565523 CNV loss 21841781
nsv565524 CNV loss 21841781
nsv827027 CNV gain 20364138
nsv832860 CNV gain 17160897
nsv952883 CNV duplication 24416366

Variation tolerance for RIN3 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.37; 96.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIN3 Gene

Disorders for RIN3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RIN3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paget's disease of bone
  • familial paget's disease of bone
- elite association - COSMIC cancer census association via MalaCards
Search RIN3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RIN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RIN3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIN3 Gene

Publications for RIN3 Gene

  1. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. (PMID: 12972505) Kajiho H. … Katada T. (J. Cell Sci. 2003) 3 4 22 64
  2. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PMID: 11733506) Saito K. … Katada T. (J. Biol. Chem. 2002) 2 3 4 64
  3. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. (PMID: 21623375) Albagha O.M. … Ralston S.H. (Nat. Genet. 2011) 3 46 64
  4. Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. (PMID: 21586568) Kajiho H. … Katada T. (J. Biol. Chem. 2011) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for RIN3 Gene

Sources for RIN3 Gene

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