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Aliases for RIN3 Gene

Aliases for RIN3 Gene

  • Ras And Rab Interactor 3 2 3
  • Ras Interaction/Interference Protein 3 4

External Ids for RIN3 Gene

Previous GeneCards Identifiers for RIN3 Gene

  • GC14P090625
  • GC14P086798
  • GC14P090970
  • GC14P091012
  • GC14P092049
  • GC14P092980
  • GC14P073162

Summaries for RIN3 Gene

Entrez Gene Summary for RIN3 Gene

  • RIN3 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases (see RAB5A; MIM 179512) (Kajiho et al., 2003 [PubMed 12972505]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RIN3 Gene

RIN3 (Ras And Rab Interactor 3) is a Protein Coding gene. GO annotations related to this gene include GTPase activator activity and Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RINL.

UniProtKB/Swiss-Prot for RIN3 Gene

  • Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIN3 Gene

Genomics for RIN3 Gene

Regulatory Elements for RIN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIN3 Gene

92,513,774 bp from pter
92,688,994 bp from pter
175,221 bases
Plus strand

Genomic View for RIN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIN3 Gene

Proteins for RIN3 Gene

  • Protein details for RIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras and Rab interactor 3
    Protein Accession:
    Secondary Accessions:
    • Q76LB3
    • Q8NF30
    • Q8TEE8
    • Q8WYP4
    • Q9H6A5
    • Q9HAG1

    Protein attributes for RIN3 Gene

    985 amino acids
    Molecular mass:
    107854 Da
    Quaternary structure:
    • Interacts with CD2AP, RAB5B, RAB31 and BIN1.
    • Sequence=BAB13888.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=BAB15357.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC03432.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIN3 Gene

    Alternative splice isoforms for RIN3 Gene


neXtProt entry for RIN3 Gene

Proteomics data for RIN3 Gene at MOPED

Post-translational modifications for RIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIN3 Gene

Antibody Products

No data available for DME Specific Peptides for RIN3 Gene

Domains for RIN3 Gene

Protein Domains for RIN3 Gene

Suggested Antigen Peptide Sequences for RIN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8TB24
  • Contains 1 Ras-associating domain.
  • Contains 1 SH2 domain.
  • Contains 1 VPS9 domain.
  • Belongs to the RIN (Ras interaction/interference) family.
genes like me logo Genes that share domains with RIN3: view

No data available for Gene Families for RIN3 Gene

Function for RIN3 Gene

Molecular function for RIN3 Gene

UniProtKB/Swiss-Prot Function:
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.

Gene Ontology (GO) - Molecular Function for RIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 17474147
GO:0017112 Rab guanyl-nucleotide exchange factor activity IMP 21586568
GO:0017137 Rab GTPase binding IDA 21586568
genes like me logo Genes that share ontologies with RIN3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RIN3 Gene

Localization for RIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIN3 Gene

Cytoplasm. Cytoplasmic vesicle. Early endosome. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.

Subcellular locations from

Jensen Localization Image for RIN3 Gene COMPARTMENTS Subcellular localization image for RIN3 gene
Compartment Confidence
endosome 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for RIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IDA 21586568
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle IDA 21586568
genes like me logo Genes that share ontologies with RIN3: view

Pathways for RIN3 Gene

SuperPathways for RIN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis NAS 11733506
GO:0007165 signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IMP 21586568
genes like me logo Genes that share ontologies with RIN3: view

No data available for Pathways by source for RIN3 Gene

Compounds for RIN3 Gene

(3) HMDB Compounds for RIN3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RIN3: view

Transcripts for RIN3 Gene

Unigene Clusters for RIN3 Gene

Ras and Rab interactor 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: -
SP2: -
SP4: -
SP5: - - - - - - - -

Relevant External Links for RIN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIN3 Gene

mRNA expression in normal human tissues for RIN3 Gene

mRNA differential expression in normal tissues according to GTEx for RIN3 Gene

This gene is overexpressed in Whole Blood (20.1).

Protein differential expression in normal tissues for RIN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.4), Monocytes (11.8), NK cells (10.0), Blymphocyte (6.3), and Lymph node (6.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RIN3 Gene

SOURCE GeneReport for Unigene cluster for RIN3 Gene Hs.326822

mRNA Expression by UniProt/SwissProt for RIN3 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RIN3: view

Expression partners for RIN3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RIN3 Gene

Orthologs for RIN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rin3 35
  • 80.92 (n)
  • 77.89 (a)
Rin3 16
Rin3 36
  • 77 (a)
(Pan troglodytes)
Mammalia RIN3 35
  • 98.81 (n)
  • 98.67 (a)
RIN3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rin3 35
  • 80.74 (n)
  • 79.57 (a)
(Bos Taurus)
Mammalia RIN3 36
  • 74 (a)
(Canis familiaris)
Mammalia RIN3 36
  • 75 (a)
(Monodelphis domestica)
Mammalia RIN3 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
-- 36
  • 82 (a)
(Gallus gallus)
Aves RIN3 35
  • 63.22 (n)
  • 60.22 (a)
RIN3 36
  • 56 (a)
(Anolis carolinensis)
Reptilia RIN3 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rin3 35
  • 64.59 (n)
  • 62.15 (a)
Str.7371 35
(Danio rerio)
Actinopterygii RIN3 36
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta spri 36
  • 10 (a)
(Caenorhabditis elegans)
Secernentea rin-1 36
  • 11 (a)
Species with no ortholog for RIN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIN3 Gene

Gene Tree for RIN3 (if available)
Gene Tree for RIN3 (if available)

Paralogs for RIN3 Gene

Paralogs for RIN3 Gene

Selected SIMAP similar genes for RIN3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RIN3: view

Variants for RIN3 Gene

Sequence variations from dbSNP and Humsavar for RIN3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs730100 -- 92,566,973(-) TGGTG(A/T)TAAAT intron-variant
rs733447 -- 92,676,306(-) GCAGC(C/T)TCCTC intron-variant
rs734206 -- 92,642,119(-) TTCAA(A/G)AAAAA intron-variant
rs734207 -- 92,642,075(-) TCTCT(A/G)CTCCC intron-variant
rs734208 -- 92,642,066(-) CCAAC(A/G)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIN3 Gene

Variant ID Type Subtype PubMed ID
nsv832860 CNV Gain 17160897
esv275342 CNV Loss 21479260
nsv509544 CNV Insertion 20534489
nsv513417 CNV Insertion 21212237
esv1630206 CNV Insertion 17803354
esv1499156 CNV Insertion 17803354
esv1485745 CNV Insertion 17803354
esv2676688 CNV Deletion 23128226
esv23961 CNV Gain 19812545
esv2749024 CNV Deletion 23290073
esv1248112 CNV Deletion 17803354
nsv522954 CNV Loss 19592680
nsv1399 CNV Insertion 18451855
nsv456399 CNV Loss 19166990
nsv827027 CNV Gain 20364138

Relevant External Links for RIN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIN3 Gene

Disorders for RIN3 Gene

Relevant External Links for RIN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RIN3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RIN3 Gene

Publications for RIN3 Gene

  1. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. (PMID: 12972505) Kajiho H. … Katada T. (J. Cell Sci. 2003) 3 4 23
  2. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PMID: 11733506) Saito K. … Katada T. (J. Biol. Chem. 2002) 2 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RIN3 Gene

Sources for RIN3 Gene

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