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RIN3 Gene

protein-coding   GIFtS: 50
GCID: GC14P092980

Ras And Rab Interactor 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras And Rab Interactor 31 2
Ras Interaction/Interference Protein 32 3
RAB5 Interacting Protein 32

External Ids:    HGNC: 187511   Entrez Gene: 798902   Ensembl: ENSG000001005997   OMIM: 6102235   UniProtKB: Q8TB243   

Export aliases for RIN3 gene to outside databases

Previous GC identifers: GC14P090625 GC14P086798 GC14P090970 GC14P091012 GC14P092049 GC14P073162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RIN3 Gene:
RIN3 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the
RAB5 small GTPases (see RAB5A; MIM 179512) (Kajiho et al., 2003 (PubMed 12972505)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RIN3 Gene:
RIN3 (Ras and Rab interactor 3) is a protein-coding gene. GO annotations related to this gene include Rab guanyl-nucleotide exchange factor activity and GTPase activator activity. An important paralog of this gene is RIN2.

UniProtKB/Swiss-Prot: RIN3_HUMAN, Q8TB24
Function: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by
exchanging bound GDP for free GTP. Required for normal RAB31 function




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RIN3 gene promoter:
         TBP   SRF   AML1a   SRF (504 AA)   E47   C/EBPalpha   CHOP-10   TFIID   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIN3 promoter sequence
   Search Chromatin IP Primers for RIN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.13

RIN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIN3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P092980:  view genomic region     (about GC identifiers)

Start:
92,980,118 bp from pter      End:
93,155,339 bp from pter
Size:
175,222 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RIN3_HUMAN, Q8TB24 (See protein sequence)
Recommended Name: Ras and Rab interactor 3  
Size: 985 amino acids; 107854 Da
Subunit: Interacts with CD2AP, RAB5B, RAB31 and BIN1
Sequence caution: Sequence=BAB13888.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=BAB15357.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC03432.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
1 PDB 3D structure from and Proteopedia for RIN3:
3U23 (3D)    
Secondary accessions: Q76LB3 Q8NF30 Q8TEE8 Q8WYP4 Q9H6A5 Q9HAG1
Alternative splicing: 2 isoforms:  Q8TB24-1   Q8TB24-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIN3: NX_Q8TB24

Explore proteomics data for RIN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RIN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079108.3  
    ENSEMBL proteins: 
     ENSP00000216487   ENSP00000450682   ENSP00000452155   ENSP00000450986  

    RIN3 Human Recombinant Protein Products:

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    Novus Biologicals RIN3 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIN3

     
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    antibodies-online proteins for RIN3 (2 products) 

     
    antibodies-online peptides for RIN3

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    antibodies-online antibodies for RIN3 (13 products) 

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    antibodies-online kits for RIN3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013995 VPS9_subgr
     IPR003123 VPS9
     IPR000159 Ras-assoc
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q8TB24

    ProtoNet protein and cluster: Q8TB24

    2 Blocks protein domains:
    IPB000159 RA domain
    IPB003123 Vacuolar sorting protein 9


    UniProtKB/Swiss-Prot: RIN3_HUMAN, Q8TB24
    Similarity: Belongs to the RIN (Ras interaction/interference) family
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 VPS9 domain


    Find genes that share domains with RIN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIN3_HUMAN, Q8TB24
    Function: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by
    exchanging bound GDP for free GTP. Required for normal RAB31 function

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI17474147
    GO:0017112Rab guanyl-nucleotide exchange factor activity IMP--
    GO:0017137Rab GTPase binding IDA--
         
    Find genes that share ontologies with RIN3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RIN3

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    8 qRT-PCR Assays for microRNAs that regulate RIN3:
    hsa-miR-4324 hsa-miR-623 hsa-miR-2110 hsa-miR-211 hsa-miR-3158-3p hsa-miR-204 hsa-miR-3119 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidRIN3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RIN3

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    GenScript: all cDNA clones in your preferred vector: RIN3 (NM_024832)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIN3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RIN3_HUMAN, Q8TB24: Cytoplasm. Cytoplasmic vesicle. Early endosome. Note=Activation of tyrosine phosphorylation
    signaling induces translocation to cytoplasmic vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IDA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0031410cytoplasmic vesicle IDA--

    Find genes that share ontologies with RIN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RIN3
    Interactions:

        GeneGlobe Interaction Network for RIN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RIN3 (Q8TB241, 2, 3 ENSP000002164874) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191741, 2, 3, ENSP000002440074EBI-1570523,EBI-79387 MINT-8112711 I2D: score=3 STRING: ENSP00000244007
    BIN1O004992, 3, ENSP000003167794MINT-58368 MINT-62883 MINT-58365 MINT-58369 I2D: score=3 STRING: ENSP00000316779
    ABL1P005192, 3, ENSP000003614234MINT-8110707 I2D: score=3 STRING: ENSP00000361423
    RGS2P412202, 3MINT-8268933 I2D: score=2 
    RABAC1Q9UI142, 3, ENSP000002220084MINT-8267819 I2D: score=2 STRING: ENSP00000222008
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis NAS11733506
    GO:0007165signal transduction IEA--
    GO:0032313regulation of Rab GTPase activity IMP--

    Find genes that share ontologies with RIN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RIN3

    3 HMDB Compounds for RIN3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RIN3 gene: 
    NM_024832.3  

    Unigene Cluster for RIN3:

    Ras and Rab interactor 3
    Hs.326822  [show with all ESTs]
    Unigene Representative Sequence: AK090451
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216487(uc001yap.3 uc010auk.3) ENST00000555589(uc001yar.1 uc001yas.1)
    ENST00000557762 ENST00000556385 ENST00000418924(uc001yaq.3) ENST00000555908
    ENST00000555891 ENST00000554888 ENST00000553992 ENST00000556418 ENST00000553959

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate RIN3:
    hsa-miR-4324 hsa-miR-623 hsa-miR-2110 hsa-miR-211 hsa-miR-3158-3p hsa-miR-204 hsa-miR-3119 hsa-miR-1910
    SwitchGear 3'UTR luciferase reporter plasmidRIN3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RIN3
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    GenScript: all cDNA clones in your preferred vector: RIN3 (NM_024832)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIN3
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIN3
      QuantiTect SYBR Green Assays in human, mouse, rat RIN3
      QuantiFast Probe-based Assays in human, mouse, rat RIN3

    Additional mRNA sequence: 

    AB060338.1 AB081753.1 AK021762.1 AK026092.1 AK074176.1 AK090451.1 AK128338.1 BC025248.1 
    BC032614.1 BC070062.1 BX248258.1 CR936654.1 

    13 DOTS entries:

    DT.311715  DT.99965078  DT.97768445  DT.95200654  DT.100785497  DT.95159544  DT.75123114  DT.99936067 
    DT.75160465  DT.92070469  DT.95115348  DT.100704334  DT.100840621 

    Selected AceView cDNA sequences (see all 155):

    BQ922056 BF512111 AA485847 BU164512 CD671501 CR620663 AI859186 BM923082 
    AI027923 AB081753 BF940697 AI871161 CD671502 AW027923 BF430921 BX432875 
    BF431888 AI523920 AI760894 AI365464 AL832844 BX114830 CA445108 AB060338 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RIN3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
    SP1:                                            -                                                               
    SP2:                                                                                                  -         
    SP3:                                                                                                            
    SP4:                                -                                                                           
    SP5:                    -     -     -     -     -     -     -     -                                             


    ECgene alternative splicing isoforms for RIN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RIN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAAGCCCA
    RIN3 Expression
    About this image

    RIN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RIN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.326822

    UniProtKB/Swiss-Prot: RIN3_HUMAN, Q8TB24
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RIN3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rin31 , 5 Ras and Rab interactor 31, 5 80.92(n)1
    77.89(a)1
      12 (51.45 cM)5
    2178351  NM_177620.41  NP_808288.21 
     1022830485 
    chicken
    (Gallus gallus)
    Aves RIN31 Ras and Rab interactor 3 63.22(n)
    60.22(a)
      423417  XM_421327.4  XP_421327.4 
    lizard
    (Anolis carolinensis)
    Reptilia RIN36
    Ras and Rab interactor 3
    56(a)
    1 ↔ 1
    1(11297491-11353290)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.73712 Transcribed sequence with weak similarity to protein more 78.35(n)    AL859062.2 
    zebrafish
    (Danio rerio)
    Actinopterygii RIN36
    Ras and Rab interactor 3
    40(a)
    1 ↔ 1
    17(33659447-33691788) ENSDARG00000077618
    fruit fly
    (Drosophila melanogaster)
    Insecta spri6
    sprint
    10(a)
    1 → many
    X(10384102-10479455)
    worm
    (Caenorhabditis elegans)
    Secernentea rin-16
    Protein RIN-1, isoform f
    11(a)
    1 → many
    V(14784152-14815600) WBGene00008183


    ENSEMBL Gene Tree for RIN3 (if available)
    TreeFam Gene Tree for RIN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RIN3 gene
    RIN22  RIN12  RINL2  
    2 SIMAP similar genes for RIN3 using alignment to 5 protein entries:     RIN3_HUMAN (see all proteins):
    DKFZp762H1613    RIN2

    Find genes that share paralogs with RIN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RIN3 (see all 4071)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2017829941,2
    --92978163(+) CCCTT-/AAAAAA 1 -- us2k10--------
    rs1405146031,2
    C--92978298(+) TTTTCA/GTCACC 1 -- us2k10--------
    rs619773381,2
    C,F--92978386(+) TCTGGA/GCTTGC 1 -- us2k13Minor allele frequency- G:0.06NA 124
    rs49049481,2
    C,A,H--92978404(+) GGACAT/CTTCAT 1 -- us2k111Minor allele frequency- C:0.27NA WA CSA EA 375
    rs1831374651,2
    --92978599(+) TTTTGA/GCTAGT 1 -- us2k10--------
    rs749552651,2
    C,F--92978621(+) TACTCT/CTTATA 1 -- us2k12Minor allele frequency- C:0.07NA EA 240
    rs1379996691,2
    --92978671(+) AACTT-/ATAC  
            
    ATGAA
    1 -- us2k10--------
    rs80106961,2
    C,F--92979009(+) gtcctG/Ctctgg 1 -- us2k12Minor allele frequency- C:0.11WA 120
    rs1884241161,2
    --92979116(+) GCCCCC/TGGAGG 1 -- us2k10--------
    rs746889481,2
    C,F--92979197(+) CATGGA/CGAGGC 1 -- us2k11Minor allele frequency- C:0.09WA 118

    HapMap Linkage Disequilibrium report for RIN3 (92980118 - 93155339 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RIN3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676688CNV Deletion23128226
    esv2749024CNV Deletion23290073
    esv1248112CNV Deletion17803354
    esv1485745CNV Insertion17803354
    nsv1399CNV Insertion18451855
    esv1630206CNV Insertion17803354
    nsv509544CNV Insertion20534489
    esv1499156CNV Insertion17803354
    nsv513417CNV Insertion21212237
    nsv456399CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610223    OMIM disorders: --


    Find genes that share disorders with RIN3           About GenesLikeMe

    Genetic Association Database (GAD): RIN3
    Human Genome Epidemiology (HuGE) Navigator: RIN3 (1 document)

    Export disorders for RIN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RIN3 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with RIN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. (PubMed id 11733506)1, 2, 3 Saito K.... Katada T. (J. Biol. Chem. 2002)
    2. RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. (PubMed id 12972505)1, 2, 9 Kajiho H....Katada T. (J. Cell Sci. 2003)
    3. Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. (PubMed id 21623375)1, 4 Albagha O.M....Ralston S.H. (Nat. Genet. 2011)
    4. Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. (PubMed id 21586568)1, 2 Kajiho H.... Katada T. (J. Biol. Chem. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5- GEF, to early endocytic vesicles. (PubMed id 18486601)1, 2 Yoshikawa M.... Katada T. (Biochem. Biophys. Res. Commun. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    10. TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-I_B and AP-1. (PubMed id 22810651)1 Hu X....Zhang J. (Mol. Biol. Rep. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79890 HGNC: 18751 AceView: RIN3 Ensembl:ENSG00000100599 euGenes: HUgn79890
    ECgene: RIN3 H-InvDB: RIN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RIN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RIN3 gene:
    Search GeneIP for patents involving RIN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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