Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIN1 Gene

protein-coding   GIFtS: 56
GCID: GC11M066099

Ras And Rab Interactor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras And Rab Interactor 11 2
Ras Inhibitor JC992 3
Ras Interaction/Interference Protein 12 3
Ras Inhibitor 12
Ras Inhibitor RIN12

External Ids:    HGNC: 187491   Entrez Gene: 96102   Ensembl: ENSG000001747917   OMIM: 6059655   UniProtKB: Q136713   

Export aliases for RIN1 gene to outside databases

Previous GC identifers: GC11M068633 GC11M067780 GC11M066349 GC11M065874 GC11M065856 GC11M062436


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RIN1 Gene: 
RIN1 (Ras and Rab interactor 1) is a protein-coding gene. Diseases associated with RIN1 include acute promyelocytic leukemia, and chronic myeloid leukemia. GO annotations related to this gene include protein binding and GTPase activator activity. An important paralog of this gene is RIN2.

UniProtKB/Swiss-Prot: RIN1_HUMAN, Q13671
Function: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive
memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding
to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling.
Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by
exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis

Gene Wiki entry for RIN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIN1 gene promoter:
         PPAR-alpha   SREBP-1a   AP-1   c-Myb   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

RIN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIN1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066099:  view genomic region     (about GC identifiers)

Start:
66,097,713 bp from pter      End:
66,104,311 bp from pter
Size:
6,599 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIN1_HUMAN, Q13671 (See protein sequence)
Recommended Name: Ras and Rab interactor 1  
Size: 783 amino acids; 84099 Da
Subunit: Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the
association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on
Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is
probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins
is regulated by phosphorylation on Ser-351
Subcellular location: Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated
Secondary accessions: O15010 Q00427 Q96CC8
Alternative splicing: 2 isoforms:  Q13671-1   Q13671-2   (Shows reduced ability to bind to Ras and 14-3-3 proteins)

Explore the universe of human proteins at neXtProt for RIN1: NX_Q13671

Explore proteomics data for RIN1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with
    14-3-3 proteins
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13671

  • RIN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIN1 Protein Expression
    REFSEQ proteins: NP_004283.2  
    ENSEMBL proteins: 
     ENSP00000310406   ENSP00000431550   ENSP00000432798   ENSP00000431185   ENSP00000400560  

    Human Recombinant Protein Products for RIN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RIN1
    GenScript Custom Purified and Recombinant Proteins Services for RIN1
    Novus Biologicals RIN1 Proteins
    Novus Biologicals RIN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIN1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane TAS7862125

    RIN1 for ontologies           About GeneDecksing



    RIN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RIN1
    GenScript Superior Antibodies for RIN1
    Novus Biologicals RIN1 Antibodies
    Abcam antibodies for RIN1
    Cloud-Clone Corp. Antibodies for RIN1 
    ThermoFisher Antibodies for RIN1
    LSBio Antibodies in human, mouse, rat for RIN1 

    Assay Products for RIN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RIN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RIN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RIN1 
    Cloud-Clone Corp. CLIAs for RIN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013995 VPS9_subgr
     IPR003123 VPS9
     IPR000159 Ras-assoc
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q13671

    ProtoNet protein and cluster: Q13671

    3 Blocks protein domains:
    IPB000159 RA domain
    IPB000980 SH2 domain signature
    IPB003123 Vacuolar sorting protein 9


    UniProtKB/Swiss-Prot: RIN1_HUMAN, Q13671
    Similarity: Belongs to the RIN (Ras interaction/interference) family
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 VPS9 domain


    RIN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIN1_HUMAN, Q13671
    Function: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive
    memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding
    to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling.
    Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by
    exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI15886098
         
    RIN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RIN1:
     Decreased POU5F1-GFP protein e 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rin1):
     behavior/neurological  nervous system 

    RIN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rin1tm1Colc for RIN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIN1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIN1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RIN1
    SwitchGear 3'UTR luciferase reporter plasmidRIN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RIN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RIN1
    Sirion Biotech Customized adenovirus for overexpression of RIN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RIN1 (see all 4)
    OriGene ORF clones in mouse, rat for RIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RIN1 (NM_007327)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIN1
    Sirion Biotech Customized lentivirus for stable overexpression of RIN1 
                         Customized lentivirus expression plasmids for stable overexpression of RIN1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RIN1
    Search LifeMap BioReagents cell lines for RIN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RIN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1ErbB1 downstream signaling
    ErbB1 downstream signaling


    1 BioSystems Pathway for RIN1
        ErbB1 downstream signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/27 Interacting proteins for RIN1 (Q136711, 2, 3 ENSP000003104064) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-366017,EBI-375543 MINT-59466 MINT-59455 MINT-59454 I2D: score=4 STRING: ENSP00000361423
    ABL2P426841, 2, 3, ENSP000003565954EBI-366017,EBI-1102694 MINT-59458 MINT-59459 I2D: score=3 STRING: ENSP00000356595
    HRASP011121, 2, 3, ENSP000003098454EBI-366017,EBI-350145 MINT-59464 I2D: score=6 STRING: ENSP00000309845
    YWHAEP622582, 3, ENSP000002643354MINT-8006004 MINT-8005139 I2D: score=3 STRING: ENSP00000264335
    ERBB2P046262, 3, ENSP000002695714MINT-74713 I2D: score=1 STRING: ENSP00000269571
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007165signal transduction IEA--

    RIN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RIN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIN1

    3 HMDB Compounds for RIN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for RIN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37.2 10 9208849 (4), 18160707 (1), 19806790 (1), 18796434 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about RIN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIN1 gene: 
    NM_004292.2  

    Unigene Cluster for RIN1:

    Ras and Rab interactor 1
    Hs.1030  [show with all ESTs]
    Unigene Representative Sequence: AB209445
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526246(uc009yrd.1) ENST00000311320(uc010roy.1 uc001ohn.1 uc010roz.1)
    ENST00000534824 ENST00000530056(uc010rpa.1) ENST00000524804 ENST00000530745
    ENST00000528006 ENST00000424433
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIN1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RIN1
    SwitchGear 3'UTR luciferase reporter plasmidRIN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RIN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIN1
    Clone
    Products:
         
    OriGene clones in human, mouse for RIN1 (see all 4)
    OriGene ORF clones in mouse, rat for RIN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): RIN1 (NM_007327)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIN1
    Sirion Biotech Customized lentivirus for stable overexpression of RIN1 
                         Customized lentivirus expression plasmids for stable overexpression of RIN1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RIN1
    OriGene qSTAR qPCR primer pairs in human, mouse for RIN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIN1

    Additional mRNA sequence: 

    AB209445.1 AK295365.1 AK297757.1 AK301430.1 BC014417.1 L36463.1 

    7 DOTS entries:

    DT.312055  DT.92421586  DT.120714359  DT.100751015  DT.100751016  DT.312056  DT.97823358 

    24/95 AceView cDNA sequences (see all 95):

    BM810572 BU195794 BF766209 BM790741 BF434426 BC014417 BX284038 BM840009 
    AI354357 BM701275 BF434342 CB111808 CN484730 AA523929 BU162426 BQ960380 
    BM850958 BM674417 AA322903 BU162849 BM839835 BM127550 BG330908 NM_004292 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RIN1    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                                            -                                       
    SP2:                                                                                    
    SP3:                                                                                    


    ECgene alternative splicing isoforms for RIN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGAGCTGC
    RIN1 Expression
    About this image


    See RIN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIN1

    SOURCE GeneReport for Unigene cluster: Hs.1030

    UniProtKB/Swiss-Prot: RIN1_HUMAN, Q13671
    Tissue specificity: Expressed in all tissues examined with high levels in brain, placenta and pancreas

        SABiosciences Custom PCR Arrays for RIN1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RIN1
    OriGene qSTAR qPCR primer pairs in human, mouse for RIN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RIN1 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rin11 , 5 Ras and Rab interactor 11, 5 80.32(n)1
    81.11(a)1
      19 (4.23 cM)5
    2258701  NM_145495.21  NP_663470.11 
     50508085 
    lizard
    (Anolis carolinensis)
    Reptilia RIN16
    Uncharacterized protein
    42(a)
    1 ↔ 1
    AAWZ02038649(3469-10656)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5687151 uncharacterized LOC568715 52.18(n)
    44.81(a)
      568715  XM_692060.1  XP_697152.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spri6
    sprint
    8(a)
    1 → many
    X(10384102-10479455)
    worm
    (Caenorhabditis elegans)
    Secernentea rin-16
    Protein TAG-333, isoform f
    8(a)
    1 → many
    V(14784152-14815600)


    ENSEMBL Gene Tree for RIN1 (if available)
    TreeFam Gene Tree for RIN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIN1 gene
    RIN22  RINL2  RIN32  
    2 SIMAP similar genes for RIN1 using alignment to 5 protein entries:     RIN1_HUMAN (see all proteins):
    RIN2    DKFZp762H1613

    RIN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/255 SNPs in RIN1 are shown (see all 255)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs359476841,2
    C,F--66099079(+) AGTTAG/CCAGCC 1 -- int18Minor allele frequency- C:0.20NA WA EA 368
    rs570043481,2
    C,F--66099135(+) ATCACC/TCATTT 1 -- int15Minor allele frequency- T:0.12WA CSA NA EA 362
    rs118237561,2
    C,F,H--66099222(+) TGCAGG/TTGCAG 1 -- int110Minor allele frequency- T:0.02NS NA WA 1304
    rs714577111,2
    C,F--66099323(+) GGAACC/ATTTTA 1 -- int13Minor allele frequency- A:0.05NA 124
    rs1906514201,2
    --66099338(+) CTGGAA/GGTCCC 1 -- int10--------
    rs22825311,2
    C,F,A,H--66099494(+) GCTGGC/TTCACC 1 -- int115Minor allele frequency- T:0.36EA NS NA WA CSA 2066
    rs1813172501,2
    --66099499(+) CTCACC/TCTCAG 1 -- int10--------
    rs2015122181,2
    C--66099608(-) GAAGCG/TGGGGG 1 -- ut310--------
    rs1132312051,2
    C,F--66099629(+) AGTATC/AAGACA 1 -- ut311Minor allele frequency- A:0.50CSA 6
    rs1408521311,2
    --66099681(+) GCTGGC/TGCTAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RIN1 (66097713 - 66104311 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RIN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294
    dgv1189n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RIN1
    DNA2.0 Custom Variant and Variant Library Synthesis for RIN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605965    OMIM disorders: --

    18 diseases for RIN1:    About MalaCards
    acute promyelocytic leukemia    chronic myeloid leukemia    lung adenocarcinoma    oral squamous cell carcinoma
    colorectal cancer    myeloid leukemia    acute myeloid leukemia    gastric adenocarcinoma
    cervical cancer    squamous cell carcinoma    cervicitis    colon cancer
    leukemia    adenocarcinoma    melanoma    breast cancer
    lung cancer    neuronitis


    RIN1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RIN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 11 7 17390061 (5), 11681006 (1)
    leukemia 5.73 1 9208849 (1)
    tumors 0 9 18089779 (5), 18160707 (1), 15885497 (1)


    Export disorders for RIN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIN1 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with RIN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Protein binding and signaling properties of RIN1 suggest a unique effector function. (PubMed id 9144171)1, 2, 3, 9 Han L.... Colicelli J. (1997)
    2. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. (PubMed id 1849280)1, 2, 3 Colicelli J....Wigler M. (1991)
    3. The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. (PubMed id 11784866)1, 2, 9 Wang Y....Colicelli J. (2002)
    4. Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. (PubMed id 11703925)1, 2, 9 Tall G.G.... Horazdovsky B.F. (2001)
    5. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. (PubMed id 9208849)1, 2, 9 Afar D.E.H.... Colicelli J. (1997)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. (PubMed id 15886098)1, 2 Hu H.... Colicelli J. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1. (PubMed id 7862125)1, 2 Han L. and Colicelli J. (1995)
    10. RIN1 is a breast tumor suppressor gene. (PubMed id 18089779)1, 9 Milstein M....Colicelli J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9610 HGNC: 18749 AceView: RIN1 Ensembl:ENSG00000174791 euGenes: HUgn9610
    ECgene: RIN1 H-InvDB: RIN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RIN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIN1 gene:
    Search GeneIP for patents involving RIN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RIN1  
     OriGene qPCR primer pairs and template standards for RIN1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RIN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RIN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RIN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RIN1   OriGene Custom Protein Services for RIN1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RIN1
     QIAGEN SeqTarget long-range PCR primers for resequencing RIN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIN1
     GenScript Custom Purified and Recombinant Proteins Services for RIN1 GenScript cDNA clones with any tag delivered in your preferred vector for RIN1
     GenScript Custom Assay Services for RIN1 GenScript Superior Antibodies for RIN1
     GenScript Custom overexpressing Cell Line Services for RIN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RIN1 promoter
     Search Chromatin IP Primers for RIN1
     RT2 qPCR Primer Assay in human, mouse, rat RIN1
     GNC Network for RIN1
     SABiosciences Custom PCR Arrays for RIN1
     Search Tocris compounds for RIN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RIN1 antibodies
     RIN1 proteins
     RIN1 lysates
     Antibodies for RIN1
     See all of Abcam's Antibodies, Kits and Proteins for RIN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RIN1
     Antibodies for RIN1
     ELISAs for RIN1
     CLIAs for RIN1
     Search LifeMap BioReagents cell lines for RIN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIN1
     SwitchGear 3'UTR luciferase reporter plasmids for RIN1
     SwitchGear Promoter luciferase reporter plasmids for RIN1
     ThermoFisher Antibodies for RIN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIN1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RIN1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIN1
    Customized:
     lentivirus for stable overexpression of RIN1
     lentivirus expression plasmids for stable overexpression of RIN1
     adenovirus for overexpression of RIN1
     LSBio Antibodies in human, mouse, rat for RIN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RIN1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4