Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RIN1 Gene

Aliases for RIN1 Gene

  • Ras And Rab Interactor 1 2 3
  • Ras Interaction/Interference Protein 1 4
  • Ras Inhibitor JC99 4

External Ids for RIN1 Gene

Previous GeneCards Identifiers for RIN1 Gene

  • GC11M068633
  • GC11M067780
  • GC11M066349
  • GC11M065874
  • GC11M065856
  • GC11M066099
  • GC11M062436

Summaries for RIN1 Gene

GeneCards Summary for RIN1 Gene

RIN1 (Ras And Rab Interactor 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and ErbB1 downstream signaling. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is RIN3.

UniProtKB/Swiss-Prot for RIN1 Gene

  • Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Gene Wiki entry for RIN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIN1 Gene

Genomics for RIN1 Gene

Regulatory Elements for RIN1 Gene

Genomic Location for RIN1 Gene

Start:
66,330,242 bp from pter
End:
66,336,840 bp from pter
Size:
6,599 bases
Orientation:
Minus strand

Genomic View for RIN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIN1 Gene

Proteins for RIN1 Gene

  • Protein details for RIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13671-RIN1_HUMAN
    Recommended name:
    Ras and Rab interactor 1
    Protein Accession:
    Q13671
    Secondary Accessions:
    • O15010
    • Q00427
    • Q96CC8

    Protein attributes for RIN1 Gene

    Size:
    783 amino acids
    Molecular mass:
    84099 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.

    Alternative splice isoforms for RIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIN1 Gene

Proteomics data for RIN1 Gene at MOPED

Post-translational modifications for RIN1 Gene

  • Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIN1 Gene

No data available for DME Specific Peptides for RIN1 Gene

Domains for RIN1 Gene

Protein Domains for RIN1 Gene

Suggested Antigen Peptide Sequences for RIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13671

UniProtKB/Swiss-Prot:

RIN1_HUMAN :
  • Q13671
Domain:
  • Contains 1 Ras-associating domain.
  • Contains 1 SH2 domain.
  • Contains 1 VPS9 domain.
Family:
  • Belongs to the RIN (Ras interaction/interference) family.
genes like me logo Genes that share domains with RIN1: view

No data available for Gene Families for RIN1 Gene

Function for RIN1 Gene

Molecular function for RIN1 Gene

UniProtKB/Swiss-Prot Function: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Gene Ontology (GO) - Molecular Function for RIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 15886098
GO:0017016 Ras GTPase binding IEA --
genes like me logo Genes that share ontologies with RIN1: view

Phenotypes for RIN1 Gene

genes like me logo Genes that share phenotypes with RIN1: view

Animal Models for RIN1 Gene

MGI Knock Outs for RIN1:

miRNA for RIN1 Gene

miRTarBase miRNAs that target RIN1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RIN1 Gene

Localization for RIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIN1 Gene

Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIN1 Gene COMPARTMENTS Subcellular localization image for RIN1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
nucleus 3
endosome 2

Gene Ontology (GO) - Cellular Components for RIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12574403
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA 12574403
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with RIN1: view

Pathways for RIN1 Gene

genes like me logo Genes that share pathways with RIN1: view

Pathways by source for RIN1 Gene

1 BioSystems pathway for RIN1 Gene
1 KEGG pathway for RIN1 Gene

Gene Ontology (GO) - Biological Process for RIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction IEA --
GO:0007613 memory IEA --
GO:0008306 associative learning IEA --
GO:0031914 negative regulation of synaptic plasticity IEA --
genes like me logo Genes that share ontologies with RIN1: view

Compounds for RIN1 Gene

(3) HMDB Compounds for RIN1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for RIN1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 37.2 9
genes like me logo Genes that share compounds with RIN1: view

Transcripts for RIN1 Gene

Unigene Clusters for RIN1 Gene

Ras and Rab interactor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIN1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3:

Relevant External Links for RIN1 Gene

GeneLoc Exon Structure for
RIN1
ECgene alternative splicing isoforms for
RIN1

Expression for RIN1 Gene

mRNA expression in normal human tissues for RIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIN1 Gene

SOURCE GeneReport for Unigene cluster for RIN1 Gene Hs.1030

mRNA Expression by UniProt/SwissProt for RIN1 Gene

Q13671-RIN1_HUMAN
Tissue specificity: Expressed in all tissues examined with high levels in brain, placenta and pancreas.
genes like me logo Genes that share expressions with RIN1: view

No data available for mRNA differential expression in normal tissues for RIN1 Gene

Orthologs for RIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIN1 35
  • 99.36 (n)
  • 99.23 (a)
RIN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RIN1 35
  • 85.82 (n)
  • 84.16 (a)
RIN1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIN1 35
  • 85.77 (n)
  • 84.34 (a)
RIN1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rin1 35
  • 80.32 (n)
  • 81.11 (a)
Rin1 16
Rin1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIN1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIN1 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii BX511131.1 36
  • 34 (a)
OneToMany
rin1a 36
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta spri 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rin-1 36
  • 10 (a)
OneToMany
Species with no ortholog for RIN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RIN1 Gene

ENSEMBL:
Gene Tree for RIN1 (if available)
TreeFam:
Gene Tree for RIN1 (if available)

Paralogs for RIN1 Gene

Paralogs for RIN1 Gene

Selected SIMAP similar genes for RIN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RIN1: view

Variants for RIN1 Gene

Sequence variations from dbSNP and Humsavar for RIN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1784029 -- 66,332,516(+) CACTC(C/T)GCCCG synonymous-codon, reference
rs1784030 -- 66,332,681(+) GAGGC(C/T)TCTGG reference, synonymous-codon
rs1785638 -- 66,332,911(+) CAGGG(A/C/G)TCGGC intron-variant
rs1785639 -- 66,332,959(+) GGGGC(A/G)CTCAC intron-variant
rs2282531 -- 66,332,023(+) GCTGG(C/T)TCACC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RIN1 Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
dgv1189n71 CNV Loss 21882294

Relevant External Links for RIN1 Gene

HapMap Linkage Disequilibrium report
RIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIN1 Gene

Disorders for RIN1 Gene

(3) Novoseek inferred disease relationships for RIN1 Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 11 6
leukemia 5.73 1
tumors 0 7
genes like me logo Genes that share disorders with RIN1: view

No data available for UniProtKB/Swiss-Prot for RIN1 Gene

Publications for RIN1 Gene

  1. Protein binding and signaling properties of RIN1 suggest a unique effector function. (PMID: 9144171) Han L. … Colicelli J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. (PMID: 9208849) Afar D.E.H. … Colicelli J. (Immunity 1997) 3 4 23
  3. The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. (PMID: 11784866) Wang Y. … Colicelli J. (Mol. Cell. Biol. 2002) 3 4 23
  4. Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. (PMID: 11703925) Tall G.G. … Horazdovsky B.F. (Dev. Cell 2001) 3 4 23
  5. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. (PMID: 1849280) Colicelli J. … Wigler M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4

Products for RIN1 Gene

Sources for RIN1 Gene

Back to Top

Content