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Aliases for RIN1 Gene

Aliases for RIN1 Gene

  • Ras And Rab Interactor 1 2 3 5
  • Ras Interaction/Interference Protein 1 4
  • Ras Inhibitor JC99 4

External Ids for RIN1 Gene

Previous GeneCards Identifiers for RIN1 Gene

  • GC11M068633
  • GC11M067780
  • GC11M066349
  • GC11M065874
  • GC11M065856
  • GC11M066099
  • GC11M062436

Summaries for RIN1 Gene

GeneCards Summary for RIN1 Gene

RIN1 (Ras And Rab Interactor 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and RAB GEFs exchange GTP for GDP on RABs. GO annotations related to this gene include GTPase activator activity and Ras GTPase binding. An important paralog of this gene is RIN2.

UniProtKB/Swiss-Prot for RIN1 Gene

  • Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Gene Wiki entry for RIN1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIN1 Gene

Genomics for RIN1 Gene

Regulatory Elements for RIN1 Gene

Enhancers for RIN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G066324 1.9 FANTOM5 Ensembl ENCODE dbSUPER 42.2 +10.3 10278 5.4 HDGF MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 RIN1 ACTN3 YIF1A TMEM151A LOC100505504 SLC29A2 ENSG00000255320 PACS1 ENSG00000201733 CTSF
GH11G066342 1.8 FANTOM5 ENCODE dbSUPER 37.3 -11.4 -11412 11.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 RIN1 EIF1AD ENSG00000258297 ACTN3 RAD9A RBM14 KAT5 ENSG00000255320 LOC105369352 CTSF
GH11G066333 1.3 ENCODE dbSUPER 51.5 +0.5 455 6.2 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 RIN1 ACTN3 ENSG00000254458 B4GAT1 RAB1B LOC105369351 LOC105369352 ENSG00000255320 PACS1 BANF1
GH11G066311 1.8 FANTOM5 ENCODE dbSUPER 28.5 +21.8 21800 8.3 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 RIN1 BRMS1 TMEM151A YIF1A LOC102724064 ENSG00000255320 PACS1 ENSG00000254458 CD248 RBM14
GH11G066903 1.5 Ensembl ENCODE dbSUPER 12.6 -569.5 -569500 5.6 FOXA2 ARID4B DMAP1 YY1 FOS SP5 NFYC PPARG ZNF623 MAFF PC C11orf80 RHOD ACTN3 CTSF RIN1 C11orf86 LRFN4 SYT12 LOC100505504
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIN1 on UCSC Golden Path with GeneCards custom track

Promoters for RIN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040957 1033 601 ELF3 TBP AGO1 NFRKB ARID4B KLF17 SIN3A SLC30A9 GATA4 PCBP1

Genomic Location for RIN1 Gene

Chromosome:
11
Start:
66,330,242 bp from pter
End:
66,337,133 bp from pter
Size:
6,892 bases
Orientation:
Minus strand

Genomic View for RIN1 Gene

Genes around RIN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIN1 Gene

Proteins for RIN1 Gene

  • Protein details for RIN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13671-RIN1_HUMAN
    Recommended name:
    Ras and Rab interactor 1
    Protein Accession:
    Q13671
    Secondary Accessions:
    • O15010
    • Q00427
    • Q96CC8

    Protein attributes for RIN1 Gene

    Size:
    783 amino acids
    Molecular mass:
    84099 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.

    Alternative splice isoforms for RIN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIN1 Gene

Post-translational modifications for RIN1 Gene

  • Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIN1 Gene

Domains & Families for RIN1 Gene

Gene Families for RIN1 Gene

Protein Domains for RIN1 Gene

Suggested Antigen Peptide Sequences for RIN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13671

UniProtKB/Swiss-Prot:

RIN1_HUMAN :
  • Belongs to the RIN (Ras interaction/interference) family.
Family:
  • Belongs to the RIN (Ras interaction/interference) family.
genes like me logo Genes that share domains with RIN1: view

Function for RIN1 Gene

Molecular function for RIN1 Gene

UniProtKB/Swiss-Prot Function:
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.

Gene Ontology (GO) - Molecular Function for RIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 9144171
GO:0017016 Ras GTPase binding IEA --
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with RIN1: view
genes like me logo Genes that share phenotypes with RIN1: view

Animal Models for RIN1 Gene

MGI Knock Outs for RIN1:

Animal Model Products

CRISPR Products

miRNA for RIN1 Gene

miRTarBase miRNAs that target RIN1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RIN1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIN1 Gene

Localization for RIN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIN1 Gene

Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Note=Some amount is membrane-associated.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIN1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
cytoskeleton 3
endosome 2

Gene Ontology (GO) - Cellular Components for RIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12574403
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA,TAS 12574403
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RIN1: view

Pathways & Interactions for RIN1 Gene

genes like me logo Genes that share pathways with RIN1: view

Pathways by source for RIN1 Gene

1 KEGG pathway for RIN1 Gene

SIGNOR curated interactions for RIN1 Gene

Activates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for RIN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007165 signal transduction IEA --
GO:0007613 memory IEA --
GO:0008306 associative learning IEA --
GO:0031914 negative regulation of synaptic plasticity IEA --
genes like me logo Genes that share ontologies with RIN1: view

Drugs & Compounds for RIN1 Gene

(4) Drugs for RIN1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIN1: view

Transcripts for RIN1 Gene

Unigene Clusters for RIN1 Gene

Ras and Rab interactor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RIN1

Alternative Splicing Database (ASD) splice patterns (SP) for RIN1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3:

Relevant External Links for RIN1 Gene

GeneLoc Exon Structure for
RIN1
ECgene alternative splicing isoforms for
RIN1

Expression for RIN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RIN1 Gene

This gene is overexpressed in Urine (25.6), Breast (24.6), and Bone (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of RIN1 Gene:

RIN1

SOURCE GeneReport for Unigene cluster for RIN1 Gene:

Hs.1030

mRNA Expression by UniProt/SwissProt for RIN1 Gene:

Q13671-RIN1_HUMAN
Tissue specificity: Expressed in all tissues examined with high levels in brain, placenta and pancreas.

Evidence on tissue expression from TISSUES for RIN1 Gene

  • Nervous system(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with RIN1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIN1 Gene

Orthologs for RIN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIN1 34 35
  • 99.36 (n)
cow
(Bos Taurus)
Mammalia RIN1 34 35
  • 85.82 (n)
dog
(Canis familiaris)
Mammalia RIN1 34 35
  • 85.77 (n)
mouse
(Mus musculus)
Mammalia Rin1 34 16 35
  • 80.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RIN1 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIN1 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rin1a 35
  • 36 (a)
OneToMany
BX511131.1 35
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta spri 35
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rin-1 35
  • 10 (a)
OneToMany
Species where no ortholog for RIN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RIN1 Gene

ENSEMBL:
Gene Tree for RIN1 (if available)
TreeFam:
Gene Tree for RIN1 (if available)

Paralogs for RIN1 Gene

Paralogs for RIN1 Gene

(2) SIMAP similar genes for RIN1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RIN1: view

Variants for RIN1 Gene

Sequence variations from dbSNP and Humsavar for RIN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000154130 -- 66,337,457(+) CAGAC(C/G)CCCAG upstream-variant-2KB, utr-variant-3-prime
rs1000810804 -- 66,332,135(+) TTCCC(C/G)CAGCT utr-variant-3-prime
rs1000835117 -- 66,339,081(+) ACCTG(A/G)CCCCT intron-variant, upstream-variant-2KB
rs1001484719 -- 66,333,063(+) GGTCC(C/T)ATTAC intron-variant
rs1001682340 -- 66,337,565(+) TTTGA(C/T)TTCGG upstream-variant-2KB, utr-variant-3-prime

Variation tolerance for RIN1 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.67; 72.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RIN1 Gene

Disorders for RIN1 Gene

Relevant External Links for RIN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIN1

No disorders were found for RIN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIN1 Gene

Publications for RIN1 Gene

  1. Protein binding and signaling properties of RIN1 suggest a unique effector function. (PMID: 9144171) Han L. … Colicelli J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. (PMID: 11784866) Wang Y. … Colicelli J. (Mol. Cell. Biol. 2002) 3 4 22 64
  3. Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. (PMID: 11703925) Tall G.G. … Horazdovsky B.F. (Dev. Cell 2001) 3 4 22 64
  4. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. (PMID: 9208849) Afar D.E.H. … Colicelli J. (Immunity 1997) 3 4 22 64
  5. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. (PMID: 1849280) Colicelli J. … Wigler M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 64

Products for RIN1 Gene

  • Addgene plasmids for RIN1

Sources for RIN1 Gene

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