Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RIMS4 Gene

Aliases for RIMS4 Gene

  • Regulating Synaptic Membrane Exocytosis 4 2 3
  • Rab3-Interacting Molecule 4 3 4
  • RIM4 Gamma 3 4
  • C20orf190 3 4
  • RIM 4 3 4
  • Regulating Synaptic Membrane Exocytosis Protein 4 3
  • Chromosome 20 Open Reading Frame 190 2
  • RIM4-Gamma 3
  • RIM4gamma 3
  • RIM-4 3
  • RIM4 3

External Ids for RIMS4 Gene

Previous HGNC Symbols for RIMS4 Gene

  • C20orf190

Previous GeneCards Identifiers for RIMS4 Gene

  • GC20U900082
  • GC20M044070
  • GC20M044065
  • GC20M042813
  • GC20M043380
  • GC20M040121

Summaries for RIMS4 Gene

GeneCards Summary for RIMS4 Gene

RIMS4 (Regulating Synaptic Membrane Exocytosis 4) is a Protein Coding gene. GO annotations related to this gene include ion channel binding. An important paralog of this gene is RIMS1.

UniProtKB/Swiss-Prot for RIMS4 Gene

  • Regulates synaptic membrane exocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMS4 Gene

Genomics for RIMS4 Gene

Regulatory Elements for RIMS4 Gene

Genomic Location for RIMS4 Gene

Start:
44,751,804 bp from pter
End:
44,810,338 bp from pter
Size:
58,535 bases
Orientation:
Minus strand

Genomic View for RIMS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIMS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMS4 Gene

Proteins for RIMS4 Gene

  • Protein details for RIMS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H426-RIMS4_HUMAN
    Recommended name:
    Regulating synaptic membrane exocytosis protein 4
    Protein Accession:
    Q9H426
    Secondary Accessions:
    • A4FU94
    • E1P613
    • Q3MI44
    • Q5JWT7

    Protein attributes for RIMS4 Gene

    Size:
    269 amino acids
    Molecular mass:
    29329 Da
    Quaternary structure:
    • Binds PPFIA3 (By similarity). Does not bind RAB3.

    Alternative splice isoforms for RIMS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIMS4 Gene

Proteomics data for RIMS4 Gene at MOPED

Post-translational modifications for RIMS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIMS4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIMS4 Gene

Domains for RIMS4 Gene

Protein Domains for RIMS4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RIMS4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H426

UniProtKB/Swiss-Prot:

RIMS4_HUMAN :
  • Q9H426
Domain:
  • Contains 1 C2 domain.
genes like me logo Genes that share domains with RIMS4: view

No data available for Gene Families for RIMS4 Gene

Function for RIMS4 Gene

Molecular function for RIMS4 Gene

UniProtKB/Swiss-Prot Function: Regulates synaptic membrane exocytosis.

Gene Ontology (GO) - Molecular Function for RIMS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044325 ion channel binding ISS --
genes like me logo Genes that share ontologies with RIMS4: view

Phenotypes for RIMS4 Gene

GenomeRNAi human phenotypes for RIMS4:
genes like me logo Genes that share phenotypes with RIMS4: view

miRNA for RIMS4 Gene

miRTarBase miRNAs that target RIMS4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RIMS4 Gene

Localization for RIMS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIMS4 Gene

Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIMS4 Gene COMPARTMENTS Subcellular localization image for RIMS4 gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RIMS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0048786 presynaptic active zone TAS 15217342
GO:0097060 synaptic membrane ISS --
genes like me logo Genes that share ontologies with RIMS4: view

Pathways for RIMS4 Gene

SuperPathways for RIMS4 Gene

No Data Available

Interacting Proteins for RIMS4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000439287%0d%0a9606.ENSP00000362931%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000439287 for RIMS4 Gene via STRING

Gene Ontology (GO) - Biological Process for RIMS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport IEA --
GO:0006887 exocytosis IEA --
GO:0042391 regulation of membrane potential ISS --
GO:2000300 regulation of synaptic vesicle exocytosis ISS --
genes like me logo Genes that share ontologies with RIMS4: view

No data available for Pathways by source for RIMS4 Gene

Transcripts for RIMS4 Gene

mRNA/cDNA for RIMS4 Gene

Unigene Clusters for RIMS4 Gene

Regulating synaptic membrane exocytosis 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIMS4 Gene

No ASD Table

Relevant External Links for RIMS4 Gene

GeneLoc Exon Structure for
RIMS4
ECgene alternative splicing isoforms for
RIMS4

Expression for RIMS4 Gene

mRNA expression in normal human tissues for RIMS4 Gene

mRNA differential expression in normal tissues according to GTEx for RIMS4 Gene

This gene is overexpressed in Brain - Cortex (5.9), Brain - Nucleus accumbens (basal ganglia) (5.6), Brain - Frontal Cortex (BA9) (4.7), Brain - Putamen (basal ganglia) (4.5), Brain - Anterior cingulate cortex (BA24) (4.5), and Brain - Caudate (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RIMS4 Gene

SOURCE GeneReport for Unigene cluster for RIMS4 Gene Hs.517065

genes like me logo Genes that share expressions with RIMS4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RIMS4 Gene

Orthologs for RIMS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIMS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIMS4 35
  • 99.63 (n)
  • 100 (a)
RIMS4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RIMS4 35
  • 94.94 (n)
  • 100 (a)
RIMS4 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIMS4 35
  • 93.54 (n)
  • 99.22 (a)
RIMS4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rims4 35
  • 92.32 (n)
  • 99.26 (a)
Rims4 16
Rims4 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RIMS4 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIMS4 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rims4 35
  • 91.95 (n)
  • 98.88 (a)
chicken
(Gallus gallus)
Aves RIMS4 35
  • 81.6 (n)
  • 92.96 (a)
RIMS4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIMS4 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rims4 35
  • 75.06 (n)
  • 87.04 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570923 35
  • 76.24 (n)
  • 85.07 (a)
RIMS4 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rim 36
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-10 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1713 36
  • 8 (a)
OneToMany
Species with no ortholog for RIMS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIMS4 Gene

ENSEMBL:
Gene Tree for RIMS4 (if available)
TreeFam:
Gene Tree for RIMS4 (if available)

Paralogs for RIMS4 Gene

Paralogs for RIMS4 Gene

Selected SIMAP similar genes for RIMS4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIMS4: view

Variants for RIMS4 Gene

Sequence variations from dbSNP and Humsavar for RIMS4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1078273 -- 44,766,939(+) TAACT(C/G)GTTAA intron-variant
rs1078342 -- 44,767,573(-) TTTAT(C/T)AAGTT intron-variant
rs1080026 -- 44,784,557(-) CAGTT(G/T)TGGGA intron-variant
rs1114162 -- 44,788,533(+) tttag(A/G)aggcc intron-variant
rs1117080 -- 44,799,682(+) AAAGG(C/G)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIMS4 Gene

Variant ID Type Subtype PubMed ID
nsv458985 CNV Gain 19166990

Relevant External Links for RIMS4 Gene

HapMap Linkage Disequilibrium report
RIMS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIMS4 Gene

Disorders for RIMS4 Gene

(1) University of Copenhagen DISEASES for RIMS4 Gene

Relevant External Links for RIMS4

Genetic Association Database (GAD)
RIMS4
Human Genome Epidemiology (HuGE) Navigator
RIMS4
genes like me logo Genes that share disorders with RIMS4: view

No data available for UniProtKB/Swiss-Prot for RIMS4 Gene

Publications for RIMS4 Gene

  1. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. (PMID: 12620390) Wang Y. … Suedhof T.C. (Genomics 2003) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for RIMS4 Gene

Sources for RIMS4 Gene

Back to Top

Content