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RIMS4 Gene

protein-coding   GIFtS: 48
GCID: GC20M043380

Regulating Synaptic Membrane Exocytosis 4

(Previous name: chromosome 20 open reading frame 190)
(Previous symbol: C20orf190)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulating Synaptic Membrane Exocytosis 41 2     RIM-42
C20orf1901 2 3     RIM42
Rab3-Interacting Molecule 42 3     RIM4-gamma2
RIM 42 3     RIM4gamma2
RIM4 Gamma2 3     Regulating Synaptic Membrane Exocytosis Protein 42
Chromosome 20 Open Reading Frame 1901     

External Ids:    HGNC: 161831   Entrez Gene: 1407302   Ensembl: ENSG000001010987   OMIM: 6116015   UniProtKB: Q9H4263   

Export aliases for RIMS4 gene to outside databases

Previous GC identifers: GC20U900082 GC20M044070 GC20M044065 GC20M042813 GC20M040121


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RIMS4 Gene:
RIMS4 (regulating synaptic membrane exocytosis 4) is a protein-coding gene. GO annotations related to this gene include ion channel binding. An important paralog of this gene is RIMS1.

UniProtKB/Swiss-Prot: RIMS4_HUMAN, Q9H426
Function: Regulates synaptic membrane exocytosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the RIMS4 gene promoter:
         Pax-5   SREBP-1c   ATF-2   NRSF form 1   NRSF form 2   SREBP-1b   RORalpha1   CRE-BP1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIMS4 promoter sequence
   Search Chromatin IP Primers for RIMS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIMS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

RIMS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIMS4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M043380:  view genomic region     (about GC identifiers)

Start:
43,380,445 bp from pter      End:
43,438,979 bp from pter
Size:
58,535 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RIMS4_HUMAN, Q9H426 (See protein sequence)
Recommended Name: Regulating synaptic membrane exocytosis protein 4  
Size: 269 amino acids; 29329 Da
Subunit: Binds PPFIA3 (By similarity). Does not bind RAB3
Secondary accessions: A4FU94 E1P613 Q3MI44 Q5JWT7
Alternative splicing: 2 isoforms:  Q9H426-1   Q9H426-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIMS4: NX_Q9H426

Explore proteomics data for RIMS4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RIMS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001192246.1  NP_892015.1  

    ENSEMBL proteins: 
     ENSP00000361942   ENSP00000439287  

    RIMS4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RIMS4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9H426

    ProtoNet protein and cluster: Q9H426

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: RIMS4_HUMAN, Q9H426
    Similarity: Contains 1 C2 domain


    Find genes that share domains with RIMS4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIMS4_HUMAN, Q9H426
    Function: Regulates synaptic membrane exocytosis (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0044325ion channel binding IEA--
         
    Find genes that share ontologies with RIMS4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RIMS4:
     Decreased Tat-dependent transc 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RIMS4
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIMS4

    miRNA
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    miRTarBase miRNAs that target RIMS4:
    hsa-mir-125b-5p (MIRT046080), hsa-mir-186-5p (MIRT021146)

    Block miRNA regulation of human, mouse, rat RIMS4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RIMS4 (see all 101):
    hsa-miR-1321 hsa-miR-1914* hsa-miR-938 hsa-miR-877* hsa-miR-149 hsa-miR-761 hsa-miR-3612 hsa-miR-490-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RIMS4_HUMAN, Q9H426: Cell junction, synapse (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030054cell junction IEA--
    GO:0097060synaptic membrane IEA--

    Find genes that share ontologies with RIMS4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RIMS4
    Interactions:

        Search GeneGlobe Interaction Network for RIMS4

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport IEA--
    GO:0006887exocytosis IEA--
    GO:0042391regulation of membrane potential IEA--

    Find genes that share ontologies with RIMS4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RIMS4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RIMS4 gene (2 alternative transcripts): 
    NM_001205317.1  NM_182970.3  

    Unigene Cluster for RIMS4:

    Regulating synaptic membrane exocytosis 4
    Hs.517065  [show with all ESTs]
    Unigene Representative Sequence: NM_001205317
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372851(uc010ggu.3 uc002xms.3) ENST00000541604
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RIMS4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RIMS4 (see all 101):
    hsa-miR-1321 hsa-miR-1914* hsa-miR-938 hsa-miR-877* hsa-miR-149 hsa-miR-761 hsa-miR-3612 hsa-miR-490-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RIMS4
    Predesigned siRNA for gene silencing in human, mouse, rat RIMS4
    Clone
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    OriGene ORF clones in mouse, rat for RIMS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RIMS4 (NM_182970)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIMS4
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RIMS4
      QuantiFast Probe-based Assays in human, mouse, rat RIMS4

    Additional mRNA sequence: 

    AK055698.1 AK095716.1 AK124626.1 AK126807.1 AY326954.1 BC036612.2 BC104190.1 BC104191.1 
    BC112985.1 BX648947.1 

    4 DOTS entries:

    DT.65287302  DT.110291  DT.120810360  DT.120810452 

    Selected AceView cDNA sequences (see all 92):

    AK124626 BU167487 AA833714 AW206818 BU729025 AL040526 AK055698 T33629 
    AW207186 BQ881878 Z39210 AI879054 AI218940 AY326954 NM_182970 AA351616 
    AW024077 AA431421 AI199767 BM475355 BQ918752 BU687239 BI196808 BI753244 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RIMS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAATTAA
    RIMS4 Expression
    About this image

    RIMS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RIMS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517065
        Custom PCR Arrays for RIMS4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RIMS4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rims41 , 5 regulating synaptic membrane exocytosis 41, 5 92.32(n)1
    99.26(a)1
      2 (84.52 cM)5
    2417701  NM_183023.11  NP_898844.11 
     1638597515 
    chicken
    (Gallus gallus)
    Aves RIMS41 regulating synaptic membrane exocytosis 4 81.6(n)
    92.96(a)
      428142  XM_425700.3  XP_425700.2 
    lizard
    (Anolis carolinensis)
    Reptilia RIMS46
    regulating synaptic membrane exocytosis 4
    92(a)
    1 ↔ 1
    4(143725845-143806772)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rims41 regulating synaptic membrane exocytosis 4 75.06(n)
    87.04(a)
      100492503  XM_004918655.1  XP_004918712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5709231 regulating synaptic membrane exocytosis protein 4-like 76.24(n)
    85.07(a)
      570923  XM_005166272.1  XP_005166329.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rim6
    Rim
    4(a)
    1 → many
    3R(13698470-13742300)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-106
    Protein UNC-10, isoform a
    6(a)
    1 → many
    X(7272324-7280320) WBGene00006750


    ENSEMBL Gene Tree for RIMS4 (if available)
    TreeFam Gene Tree for RIMS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RIMS4 gene
    RIMS12  RIMS32  RIMS22  
    4 SIMAP similar genes for RIMS4 using alignment to 2 protein entries:     RIMS4_HUMAN (see all proteins):
    RIMS2    RIMS3    RIMS1    CHR11SYT

    Find genes that share paralogs with RIMS4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RIMS4 (see all 1154)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447157871,2
    C--43381465(+) AGGCT-/AATGGC 2 -- ut310--------
    rs116996871,2
    C,H--43381535(+) GTCAGA/CTGGGC 2 -- ut31 ese31Minor allele frequency- C:0.00NA 2
    rs1155951121,2
    C--43381559(+) GAGCTC/GAGTCT 2 -- ut310--------
    rs1899389711,2
    --43381698(+) GCAACA/GGTCTC 2 -- ut310--------
    rs1393049711,2
    C--43381745(+) CCCCTC/TTGCAC 2 -- ut310--------
    rs1931991651,2
    --43381899(+) TGGCAG/TCCCCA 2 -- ut310--------
    rs1123786561,2
    C,F--43381954(+) GGACCC/AAGGCT 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs130391411,2
    H--43381956(+) ACCCAG/TGCTGG 2 -- ut31 ese34Minor allele frequency- T:0.00NS EA 390
    rs283736511,2
    C--43381988(+) TGACTC/TCAGGG 2 -- ut31 ese35Minor allele frequency- T:0.09WA CSA NA EA 361
    rs1465779721,2
    C--43382102(+) AGATGC/GCTCCT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RIMS4 (43380445 - 43438979 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RIMS4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458985CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RIMS4
    DNA2.0 Custom Variant and Variant Library Synthesis for RIMS4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611601    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RIMS4:
    Polydactyly

    Find genes that share disorders with RIMS4           About GenesLikeMe

    Genetic Association Database (GAD): RIMS4
    Human Genome Epidemiology (HuGE) Navigator: RIMS4 (2 documents)

    Export disorders for RIMS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RIMS4 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with RIMS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. (PubMed id 12620390)1, 2, 3 Wang Y. and Suedhof T.C. (Genomics 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140730 HGNC: 16183 AceView: RIMS4 Ensembl:ENSG00000101098 euGenes: HUgn140730
    ECgene: RIMS4 H-InvDB: RIMS4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RIMS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RIMS4 gene:
    Search GeneIP for patents involving RIMS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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