Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RIMS4 Gene

Aliases for RIMS4 Gene

  • Regulating Synaptic Membrane Exocytosis 4 2 3 5
  • Rab3-Interacting Molecule 4 3 4
  • RIM4 Gamma 3 4
  • C20orf190 3 4
  • RIM 4 3 4
  • Regulating Synaptic Membrane Exocytosis Protein 4 3
  • Chromosome 20 Open Reading Frame 190 2
  • RIM4-Gamma 3
  • RIM4gamma 3
  • RIM-4 3
  • RIM4 3

External Ids for RIMS4 Gene

Previous HGNC Symbols for RIMS4 Gene

  • C20orf190

Previous GeneCards Identifiers for RIMS4 Gene

  • GC20U900082
  • GC20M044070
  • GC20M044065
  • GC20M042813
  • GC20M043380
  • GC20M040121

Summaries for RIMS4 Gene

GeneCards Summary for RIMS4 Gene

RIMS4 (Regulating Synaptic Membrane Exocytosis 4) is a Protein Coding gene. GO annotations related to this gene include ion channel binding. An important paralog of this gene is RIMS1.

UniProtKB/Swiss-Prot for RIMS4 Gene

  • Regulates synaptic membrane exocytosis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMS4 Gene

Genomics for RIMS4 Gene

Regulatory Elements for RIMS4 Gene

Enhancers for RIMS4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G044867 1.1 Ensembl ENCODE 10.8 -57.3 -57278 0.4 ELF3 ZNF2 RAD21 ZNF121 ZNF366 ZNF143 ZNF391 U2AF2 SMARCA5 ZNF654 PABPC1L YWHAB KCNK15-AS1 KCNK15 RIMS4 LINC01260 GC20M044881 GC20M044880 PGBD4P2
GH20G044860 1 Ensembl ENCODE 11.3 -52.3 -52256 3.2 FOXA2 PKNOX1 NFIB TAL1 ZNF384 ZIC2 TEAD3 TCF12 ARID3A FOS YWHAB KCNK15 KCNK15-AS1 RIMS4 WISP2 LINC01260 PABPC1L GC20M044881 GC20M044880 PGBD4P2
GH20G044837 0.7 ENCODE 12 -27.9 -27883 1.2 ZNF362 ZSCAN4 ZNF121 ZSCAN21 GATA3 NFIC POLR2A ZNF629 FOXJ2 KDM1A RIMS4 KCNK15-AS1 KCNK15 LINC01260 PABPC1L YWHAB PGBD4P2
GH20G044785 0.6 ENCODE 13.1 +24.2 24230 0.4 CTCF PKNOX1 NFIB TEAD4 REST RAD21 ZNF23 ZFHX2 GATA3 KLF16 RIMS4 KCNK15-AS1 KCNK15 LINC01260 PABPC1L PIR49731
GH20G044849 0.6 ENCODE 11.8 -40.8 -40815 3.2 CTCF NFIA TEAD4 JUNB CEBPB CEBPG RAD21 NFIC MAFK YWHAB RIMS4 KCNK15 KCNK15-AS1 LINC01260 PABPC1L TOMM34 PGBD4P2 GC20M044880 GC20M044881
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIMS4 on UCSC Golden Path with GeneCards custom track

Promoters for RIMS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137587 -62 401 CTCF MAZ ZBTB8A EP300 E2F1 FOXM1 IKZF1 ZSCAN29 IKZF2 ZBTB26

Genomic Location for RIMS4 Gene

Chromosome:
20
Start:
44,751,804 bp from pter
End:
44,810,338 bp from pter
Size:
58,535 bases
Orientation:
Minus strand

Genomic View for RIMS4 Gene

Genes around RIMS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIMS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIMS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMS4 Gene

Proteins for RIMS4 Gene

  • Protein details for RIMS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H426-RIMS4_HUMAN
    Recommended name:
    Regulating synaptic membrane exocytosis protein 4
    Protein Accession:
    Q9H426
    Secondary Accessions:
    • A4FU94
    • E1P613
    • Q3MI44
    • Q5JWT7

    Protein attributes for RIMS4 Gene

    Size:
    269 amino acids
    Molecular mass:
    29329 Da
    Quaternary structure:
    • Binds PPFIA3 (By similarity). Does not bind RAB3.

    Alternative splice isoforms for RIMS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIMS4 Gene

Post-translational modifications for RIMS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIMS4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIMS4 Gene

Domains & Families for RIMS4 Gene

Gene Families for RIMS4 Gene

Protein Domains for RIMS4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RIMS4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RIMS4: view

No data available for UniProtKB/Swiss-Prot for RIMS4 Gene

Function for RIMS4 Gene

Molecular function for RIMS4 Gene

UniProtKB/Swiss-Prot Function:
Regulates synaptic membrane exocytosis.

Gene Ontology (GO) - Molecular Function for RIMS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044325 ion channel binding IEA,ISS --
genes like me logo Genes that share ontologies with RIMS4: view
genes like me logo Genes that share phenotypes with RIMS4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIMS4 Gene

Localization for RIMS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIMS4 Gene

Cell junction, synapse.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIMS4 gene
Compartment Confidence
plasma membrane 3
cytosol 3
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RIMS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0045202 synapse IEA --
GO:0048786 presynaptic active zone TAS 15217342
GO:0097060 synaptic membrane ISS,IEA --
genes like me logo Genes that share ontologies with RIMS4: view

Pathways & Interactions for RIMS4 Gene

SuperPathways for RIMS4 Gene

No Data Available

Interacting Proteins for RIMS4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000439287%0d%0a9606.ENSP00000242796%0d%0a
Selected Interacting proteins: ENSP00000439287 Q9H426-RIMS4_HUMAN for RIMS4 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RIMS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport IEA --
GO:0006887 exocytosis IEA --
GO:0042391 regulation of membrane potential ISS,IEA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
GO:2000300 regulation of synaptic vesicle exocytosis IBA,ISS --
genes like me logo Genes that share ontologies with RIMS4: view

No data available for Pathways by source and SIGNOR curated interactions for RIMS4 Gene

Drugs & Compounds for RIMS4 Gene

No Compound Related Data Available

Transcripts for RIMS4 Gene

mRNA/cDNA for RIMS4 Gene

Unigene Clusters for RIMS4 Gene

Regulating synaptic membrane exocytosis 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIMS4 Gene

No ASD Table

Relevant External Links for RIMS4 Gene

GeneLoc Exon Structure for
RIMS4
ECgene alternative splicing isoforms for
RIMS4

Expression for RIMS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIMS4 Gene

mRNA differential expression in normal tissues according to GTEx for RIMS4 Gene

This gene is overexpressed in Brain - Cortex (x5.9), Brain - Nucleus accumbens (basal ganglia) (x5.6), Brain - Frontal Cortex (BA9) (x4.7), Brain - Putamen (basal ganglia) (x4.5), Brain - Anterior cingulate cortex (BA24) (x4.5), and Brain - Caudate (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for RIMS4 Gene

This gene is overexpressed in Uterus (28.8), Plasma (28.0), and Heart (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RIMS4 Gene



Protein tissue co-expression partners for RIMS4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RIMS4 Gene:

RIMS4

SOURCE GeneReport for Unigene cluster for RIMS4 Gene:

Hs.517065

Evidence on tissue expression from TISSUES for RIMS4 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with RIMS4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIMS4 Gene

Orthologs for RIMS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIMS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIMS4 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia RIMS4 34 35
  • 94.94 (n)
dog
(Canis familiaris)
Mammalia RIMS4 34 35
  • 93.54 (n)
mouse
(Mus musculus)
Mammalia Rims4 34 16 35
  • 92.32 (n)
rat
(Rattus norvegicus)
Mammalia Rims4 34
  • 91.95 (n)
oppossum
(Monodelphis domestica)
Mammalia RIMS4 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIMS4 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIMS4 34 35
  • 81.6 (n)
lizard
(Anolis carolinensis)
Reptilia RIMS4 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rims4 34
  • 75.06 (n)
zebrafish
(Danio rerio)
Actinopterygii RIMS4 35
  • 84 (a)
OneToOne
LOC570923 34
  • 76.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rim 35
  • 4 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-10 35
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1713 35
  • 8 (a)
OneToMany
Species where no ortholog for RIMS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIMS4 Gene

ENSEMBL:
Gene Tree for RIMS4 (if available)
TreeFam:
Gene Tree for RIMS4 (if available)

Paralogs for RIMS4 Gene

Paralogs for RIMS4 Gene

(4) SIMAP similar genes for RIMS4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIMS4: view

Variants for RIMS4 Gene

Sequence variations from dbSNP and Humsavar for RIMS4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000058770 -- 44,803,797(+) CAGGG(C/T)AGACA intron-variant
rs1000068025 -- 44,752,084(+) CTCCA(C/T)TCTGA utr-variant-3-prime
rs1000161056 -- 44,803,905(+) GTGGG(G/T)GGATT intron-variant
rs1000166848 -- 44,758,268(+) ATGCA(A/G)TGGAT intron-variant
rs1000218271 -- 44,757,939(+) TGAGA(A/G)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIMS4 Gene

Variant ID Type Subtype PubMed ID
esv3447889 CNV duplication 20981092
esv3645917 CNV loss 21293372
nsv1056102 CNV loss 25217958
nsv1072542 CNV deletion 25765185
nsv1122033 CNV deletion 24896259
nsv1144937 CNV deletion 24896259
nsv458985 CNV gain 19166990
nsv586076 CNV gain 21841781

Variation tolerance for RIMS4 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIMS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIMS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIMS4 Gene

Disorders for RIMS4 Gene

Relevant External Links for RIMS4

Genetic Association Database (GAD)
RIMS4
Human Genome Epidemiology (HuGE) Navigator
RIMS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIMS4

No disorders were found for RIMS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIMS4 Gene

Publications for RIMS4 Gene

  1. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. (PMID: 12620390) Wang Y. … Suedhof T.C. (Genomics 2003) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RIMS4 Gene

Sources for RIMS4 Gene

Content
Loading form....