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Aliases for RIMS3 Gene

Aliases for RIMS3 Gene

  • Regulating Synaptic Membrane Exocytosis 3 2 3 5
  • Rab-3-Interacting Molecule 3 3 4
  • RIM3 Gamma 3 4
  • RIM 3 3 4
  • NIM3 3 4
  • Rab-3 Interacting Molecule 3 3
  • KIAA0237 4
  • RIM3 3

External Ids for RIMS3 Gene

Previous GeneCards Identifiers for RIMS3 Gene

  • GC01M040549
  • GC01M040499
  • GC01M040505
  • GC01M040755
  • GC01M040858
  • GC01M041086
  • GC01M039204

Summaries for RIMS3 Gene

GeneCards Summary for RIMS3 Gene

RIMS3 (Regulating Synaptic Membrane Exocytosis 3) is a Protein Coding gene. GO annotations related to this gene include ion channel binding. An important paralog of this gene is RIMS1.

UniProtKB/Swiss-Prot for RIMS3 Gene

  • Regulates synaptic membrane exocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMS3 Gene

Genomics for RIMS3 Gene

Regulatory Elements for RIMS3 Gene

Promoters for RIMS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RIMS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIMS3 Gene

40,620,679 bp from pter
40,692,084 bp from pter
71,406 bases
Minus strand

Genomic View for RIMS3 Gene

Genes around RIMS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIMS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIMS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMS3 Gene

Proteins for RIMS3 Gene

  • Protein details for RIMS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulating synaptic membrane exocytosis protein 3
    Protein Accession:
    Secondary Accessions:
    • D3DPV8
    • Q92511
    • X5D7U7

    Protein attributes for RIMS3 Gene

    308 amino acids
    Molecular mass:
    32796 Da
    Quaternary structure:
    • Binds PPFIA3 (By similarity). Does not bind RAB3.
    • Sequence=BAA13243.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RIMS3 Gene


neXtProt entry for RIMS3 Gene

Proteomics data for RIMS3 Gene at MOPED

Post-translational modifications for RIMS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIMS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RIMS3 Gene

Domains & Families for RIMS3 Gene

Gene Families for RIMS3 Gene

Protein Domains for RIMS3 Gene


Suggested Antigen Peptide Sequences for RIMS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
genes like me logo Genes that share domains with RIMS3: view

Function for RIMS3 Gene

Molecular function for RIMS3 Gene

UniProtKB/Swiss-Prot Function:
Regulates synaptic membrane exocytosis.
genes like me logo Genes that share phenotypes with RIMS3: view

Animal Models for RIMS3 Gene

MGI Knock Outs for RIMS3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIMS3 Gene

Localization for RIMS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIMS3 Gene

Cell junction, synapse.

Subcellular locations from

Jensen Localization Image for RIMS3 Gene COMPARTMENTS Subcellular localization image for RIMS3 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for RIMS3 Gene

Pathways & Interactions for RIMS3 Gene

SuperPathways for RIMS3 Gene

No Data Available

Interacting Proteins for RIMS3 Gene

Gene Ontology (GO) - Biological Process for RIMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017156 calcium ion regulated exocytosis ISS --
GO:0042391 regulation of membrane potential ISS --
genes like me logo Genes that share ontologies with RIMS3: view

No data available for Pathways by source and SIGNOR curated interactions for RIMS3 Gene

Drugs & Compounds for RIMS3 Gene

No Compound Related Data Available

Transcripts for RIMS3 Gene

Unigene Clusters for RIMS3 Gene

Regulating synaptic membrane exocytosis 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIMS3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: -

Relevant External Links for RIMS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIMS3 Gene

mRNA expression in normal human tissues for RIMS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIMS3 Gene

This gene is overexpressed in Brain - Cortex (x10.0), Brain - Frontal Cortex (BA9) (x8.8), and Brain - Anterior cingulate cortex (BA24) (x6.1).

Protein differential expression in normal tissues from HIPED for RIMS3 Gene

This gene is overexpressed in Breast (35.1), Brain (23.8), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIMS3 Gene

SOURCE GeneReport for Unigene cluster for RIMS3 Gene Hs.654808

genes like me logo Genes that share expression patterns with RIMS3: view

Protein tissue co-expression partners for RIMS3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RIMS3 Gene

Orthologs for RIMS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIMS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RIMS3 35
  • 91.77 (n)
  • 96.1 (a)
RIMS3 36
  • 96 (a)
(Canis familiaris)
Mammalia RIMS3 35
  • 92.75 (n)
  • 97.4 (a)
RIMS3 36
  • 97 (a)
(Mus musculus)
Mammalia Rims3 35
  • 90.34 (n)
  • 98.05 (a)
Rims3 16
Rims3 36
  • 98 (a)
(Pan troglodytes)
Mammalia RIMS3 35
  • 99.89 (n)
  • 100 (a)
RIMS3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rims3 35
  • 90.88 (n)
  • 97.39 (a)
(Monodelphis domestica)
Mammalia RIMS3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RIMS3 36
  • 85 (a)
(Gallus gallus)
Aves RIMS3 35
  • 79.61 (n)
  • 81.58 (a)
RIMS3 36
  • 80 (a)
(Anolis carolinensis)
Reptilia RIMS3 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rims3 35
  • 75.55 (n)
  • 83.88 (a)
(Danio rerio)
Actinopterygii rims3 35
  • 74.02 (n)
  • 79.93 (a)
rims3 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rim 36
  • 4 (a)
(Caenorhabditis elegans)
Secernentea unc-10 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1713 36
  • 9 (a)
Species with no ortholog for RIMS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIMS3 Gene

Gene Tree for RIMS3 (if available)
Gene Tree for RIMS3 (if available)

Paralogs for RIMS3 Gene

Paralogs for RIMS3 Gene

(3) SIMAP similar genes for RIMS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIMS3: view

Variants for RIMS3 Gene

Sequence variations from dbSNP and Humsavar for RIMS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs488096 -- 40,651,500(-) ttaaa(A/G)caaca intron-variant
rs489222 -- 40,683,422(-) ccaaa(C/T)gtatc intron-variant
rs482527 -- 40,634,704(-) TCAGC(C/T)TCCCA intron-variant
rs507634 -- 40,627,694(-) AGCCC(A/G)GGAGG intron-variant
rs507914 -- 40,686,529(-) CAGGC(A/G)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIMS3 Gene

Variant ID Type Subtype PubMed ID
nsv599 CNV Loss 18451855
esv2747397 CNV Deletion 23290073

Variation tolerance for RIMS3 Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIMS3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIMS3 Gene

Disorders for RIMS3 Gene

Relevant External Links for RIMS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RIMS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIMS3 Gene

Publications for RIMS3 Gene

  1. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. (PMID: 12620390) Wang Y. … Suedhof T.C. (Genomics 2003) 2 3 4 67
  2. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. (PMID: 10748113) Wang Y. … Sudhof T.C. (J. Biol. Chem. 2000) 2 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for RIMS3 Gene

Sources for RIMS3 Gene

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