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Aliases for RIMS3 Gene

Aliases for RIMS3 Gene

  • Regulating Synaptic Membrane Exocytosis 3 2 3
  • NIM3 3 4 6
  • Rab-3-Interacting Molecule 3 3 4
  • RIM3 Gamma 3 4
  • RIM 3 3 4
  • Regulating Synaptic Membrane Exocytosis Protein 3 3
  • Rab-3 Interacting Molecule 3 3
  • KIAA0137 6
  • KIAA0237 4
  • RIM3 3

External Ids for RIMS3 Gene

Previous GeneCards Identifiers for RIMS3 Gene

  • GC01M040549
  • GC01M040499
  • GC01M040505
  • GC01M040755
  • GC01M040858
  • GC01M041086
  • GC01M039204

Summaries for RIMS3 Gene

GeneCards Summary for RIMS3 Gene

RIMS3 (Regulating Synaptic Membrane Exocytosis 3) is a Protein Coding gene. GO annotations related to this gene include ion channel binding. An important paralog of this gene is RIMS4.

UniProtKB/Swiss-Prot for RIMS3 Gene

  • Regulates synaptic membrane exocytosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMS3 Gene

Genomics for RIMS3 Gene

Regulatory Elements for RIMS3 Gene

Genomic Location for RIMS3 Gene

40,620,679 bp from pter
40,665,657 bp from pter
44,979 bases
Minus strand

Genomic View for RIMS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIMS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMS3 Gene

Proteins for RIMS3 Gene

  • Protein details for RIMS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulating synaptic membrane exocytosis protein 3
    Protein Accession:
    Secondary Accessions:
    • D3DPV8
    • Q92511
    • X5D7U7

    Protein attributes for RIMS3 Gene

    308 amino acids
    Molecular mass:
    32796 Da
    Quaternary structure:
    • Binds PPFIA3 (By similarity). Does not bind RAB3.
    • Sequence=BAA13243.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RIMS3 Gene


neXtProt entry for RIMS3 Gene

Proteomics data for RIMS3 Gene at MOPED

Post-translational modifications for RIMS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIMS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RIMS3 Gene

Domains for RIMS3 Gene

Gene Families for RIMS3 Gene

Protein Domains for RIMS3 Gene


Suggested Antigen Peptide Sequences for RIMS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
genes like me logo Genes that share domains with RIMS3: view

Function for RIMS3 Gene

Molecular function for RIMS3 Gene

UniProtKB/Swiss-Prot Function:
Regulates synaptic membrane exocytosis.

Gene Ontology (GO) - Molecular Function for RIMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044325 ion channel binding ISS --
genes like me logo Genes that share ontologies with RIMS3: view

Phenotypes for RIMS3 Gene

genes like me logo Genes that share phenotypes with RIMS3: view

Animal Model Products

CRISPR Products

miRNA for RIMS3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIMS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RIMS3 Gene

Localization for RIMS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIMS3 Gene

Cell junction, synapse.

Subcellular locations from

Jensen Localization Image for RIMS3 Gene COMPARTMENTS Subcellular localization image for RIMS3 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RIMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0048786 presynaptic active zone TAS 15217342
genes like me logo Genes that share ontologies with RIMS3: view

Pathways for RIMS3 Gene

SuperPathways for RIMS3 Gene

No Data Available

Interacting Proteins for RIMS3 Gene

Gene Ontology (GO) - Biological Process for RIMS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006836 neurotransmitter transport IEA --
GO:0017156 calcium ion-dependent exocytosis ISS --
GO:0042391 regulation of membrane potential ISS --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
GO:2000300 regulation of synaptic vesicle exocytosis ISS --
genes like me logo Genes that share ontologies with RIMS3: view

No data available for Pathways by source for RIMS3 Gene

Transcripts for RIMS3 Gene

Unigene Clusters for RIMS3 Gene

Regulating synaptic membrane exocytosis 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIMS3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIMS3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP2: -

Relevant External Links for RIMS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIMS3 Gene

mRNA expression in normal human tissues for RIMS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIMS3 Gene

This gene is overexpressed in Brain - Cortex (10.0), Brain - Frontal Cortex (BA9) (8.8), and Brain - Anterior cingulate cortex (BA24) (6.1).

Protein differential expression in normal tissues for RIMS3 Gene

This gene is overexpressed in Breast (35.1), Brain (23.8), and Frontal cortex (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RIMS3 Gene

SOURCE GeneReport for Unigene cluster for RIMS3 Gene Hs.654808

genes like me logo Genes that share expressions with RIMS3: view

Expression partners for RIMS3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RIMS3 Gene

Orthologs for RIMS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIMS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RIMS3 35
  • 91.77 (n)
  • 96.1 (a)
RIMS3 36
  • 96 (a)
(Canis familiaris)
Mammalia RIMS3 35
  • 92.75 (n)
  • 97.4 (a)
RIMS3 36
  • 97 (a)
(Mus musculus)
Mammalia Rims3 35
  • 90.34 (n)
  • 98.05 (a)
Rims3 16
Rims3 36
  • 98 (a)
(Pan troglodytes)
Mammalia RIMS3 35
  • 99.89 (n)
  • 100 (a)
RIMS3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rims3 35
  • 90.88 (n)
  • 97.39 (a)
(Monodelphis domestica)
Mammalia RIMS3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RIMS3 36
  • 85 (a)
(Gallus gallus)
Aves RIMS3 35
  • 79.61 (n)
  • 81.58 (a)
RIMS3 36
  • 80 (a)
(Anolis carolinensis)
Reptilia RIMS3 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rims3 35
  • 75.55 (n)
  • 83.88 (a)
(Danio rerio)
Actinopterygii rims3 35
  • 74.02 (n)
  • 79.93 (a)
rims3 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rim 36
  • 4 (a)
(Caenorhabditis elegans)
Secernentea unc-10 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1713 36
  • 9 (a)
Species with no ortholog for RIMS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIMS3 Gene

Gene Tree for RIMS3 (if available)
Gene Tree for RIMS3 (if available)

Paralogs for RIMS3 Gene

Paralogs for RIMS3 Gene

(3) SIMAP similar genes for RIMS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIMS3: view

Variants for RIMS3 Gene

Sequence variations from dbSNP and Humsavar for RIMS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs500789 -- 40,663,325(-) TCTGT(A/G)TGTAC intron-variant
rs512203 -- 40,660,596(-) tcaag(A/G)ccagc intron-variant
rs588940 -- 40,639,777(-) CATCT(A/G)GTACG intron-variant
rs593634 -- 40,667,593(-) CCCAT(C/G)CAGTC upstream-variant-2KB
rs627178 -- 40,662,304(-) GAGGC(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIMS3 Gene

Variant ID Type Subtype PubMed ID
nsv599 CNV Loss 18451855
esv2747397 CNV Deletion 23290073

Relevant External Links for RIMS3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIMS3 Gene

Disorders for RIMS3 Gene

Relevant External Links for RIMS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RIMS3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RIMS3 Gene

Publications for RIMS3 Gene

  1. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. (PMID: 12620390) Wang Y. … Suedhof T.C. (Genomics 2003) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. (PMID: 10748113) Wang Y. … Sudhof T.C. (J. Biol. Chem. 2000) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for RIMS3 Gene

Sources for RIMS3 Gene

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