Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RIMS3 Gene

protein-coding   GIFtS: 55
GCID: GC01M041086

Regulating Synaptic Membrane Exocytosis 3

  Search for RIMS3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Regulating Synaptic Membrane Exocytosis 31 2     Rab-3 Interacting Molecule 32
Rab-3-Interacting Molecule 32 3     Regulating Synaptic Membrane Exocytosis Protein 32
RIM 32 3     KIAA02373
RIM3 Gamma2 3     Nim33
NIM32 5     KIAA01375
RIM32     

External Ids:    HGNC: 212921   Entrez Gene: 97832   Ensembl: ENSG000001170167   OMIM: 6116005   UniProtKB: Q9UJD03   

Export aliases for RIMS3 gene to outside databases

Previous GC identifers: GC01M040549 GC01M040499 GC01M040505 GC01M040755 GC01M040858 GC01M039204


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RIMS3 Gene:
RIMS3 (regulating synaptic membrane exocytosis 3) is a protein-coding gene. GO annotations related to this gene include ion channel binding. An important paralog of this gene is RIMS1.

UniProtKB/Swiss-Prot: RIMS3_HUMAN, Q9UJD0
Function: Regulates synaptic membrane exocytosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RIMS3 gene promoter:
         E2F-4   E2F-3a   E2F-5   NRSF form 1   E2F-2   NRSF form 2   GATA-1   YY1   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIMS3 promoter sequence
   Search Chromatin IP Primers for RIMS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIMS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

RIMS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIMS3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M041086:  view genomic region     (about GC identifiers)

Start:
41,086,351 bp from pter      End:
41,131,329 bp from pter
Size:
44,979 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RIMS3_HUMAN, Q9UJD0 (See protein sequence)
Recommended Name: Regulating synaptic membrane exocytosis protein 3  
Size: 308 amino acids; 32796 Da
Subunit: Binds PPFIA3 (By similarity). Does not bind RAB3
Sequence caution: Sequence=BAA13243.2; Type=Erroneous initiation;
Secondary accessions: D3DPV8 Q92511

Explore the universe of human proteins at neXtProt for RIMS3: NX_Q9UJD0

Explore proteomics data for RIMS3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RIMS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055562.2  
    ENSEMBL proteins: 
     ENSP00000361769   ENSP00000361768  

    RIMS3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RIMS3
    OriGene Protein Over-expression Lysate for RIMS3
    OriGene MassSpec for RIMS3
    OriGene Custom Protein Services for RIMS3
    GenScript Custom Purified and Recombinant Proteins Services for RIMS3
    Novus Biologicals RIMS3 Protein
    Novus Biologicals RIMS3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RIMS3

     
    Search eBioscience for Proteins for RIMS3 

    RIMS3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RIMS3
    OriGene Custom Antibody Services for RIMS3
    Novus Biologicals RIMS3 Antibodies
    Abcam antibodies for RIMS3
    Cloud-Clone Corp. Antibodies for RIMS3
    ThermoFisher Antibodies for RIMS3
    LSBio Antibodies in human, mouse, rat for RIMS3

    RIMS3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RIMS3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RIMS3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RIMS3
    Cloud-Clone Corp. CLIAs for RIMS3
    Search eBioscience for ELISAs for RIMS3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9UJD0

    ProtoNet protein and cluster: Q9UJD0

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: RIMS3_HUMAN, Q9UJD0
    Similarity: Contains 1 C2 domain


    Find genes that share domains with RIMS3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIMS3_HUMAN, Q9UJD0
    Function: Regulates synaptic membrane exocytosis (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0044325ion channel binding IEA--
         
    Find genes that share ontologies with RIMS3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RIMS3:
     Decreased TP53 protein express 

         1 MGI phenotypic allele for Rims3 (no phenotypes)

    Find genes that share phenotypes with RIMS3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RIMS3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RIMS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIMS3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIMS3

    miRNA
    Products:
        
    miRTarBase miRNAs that target RIMS3:
    hsa-mir-186-5p (MIRT021100), hsa-mir-16-5p (MIRT031509), hsa-mir-103a-3p (MIRT027028), hsa-mir-375 (MIRT019723)

    Block miRNA regulation of human, mouse, rat RIMS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RIMS3 (see all 115):
    hsa-miR-579 hsa-miR-607 hsa-miR-642a hsa-miR-3194-5p hsa-miR-15a hsa-miR-1258 hsa-miR-128 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RIMS3
    Predesigned siRNA for gene silencing in human, mouse, rat RIMS3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RIMS3

    Clone
    Products:
         
    OriGene clones in human, mouse for RIMS3 (see all 6)
    OriGene ORF clones in mouse, rat for RIMS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIMS3 (NM_014747)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIMS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIMS3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RIMS3
    Browse ESI BIO Cell Lines and PureStem Progenitors for RIMS3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RIMS3_HUMAN, Q9UJD0: Cell junction, synapse (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030054cell junction IEA--
    GO:0045202synapse IEA--

    Find genes that share ontologies with RIMS3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RIMS3
    Interactions:

        Search GeneGlobe Interaction Network for RIMS3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for RIMS3 (Q9UJD03 ENSP000003617684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    YWHAEP622583I2D: score=1 
    GJA5ENSP000002713484STRING: ENSP00000271348
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport IEA--
    GO:0006887exocytosis IEA--
    GO:0042391regulation of membrane potential IEA--

    Find genes that share ontologies with RIMS3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RIMS3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RIMS3 gene: 
    NM_014747.2  

    Unigene Cluster for RIMS3:

    Regulating synaptic membrane exocytosis 3
    Hs.654808  [show with all ESTs]
    Unigene Representative Sequence: D87074
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372684(uc001cfu.1 uc001cfv.1) ENST00000372683
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RIMS3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RIMS3 (see all 115):
    hsa-miR-579 hsa-miR-607 hsa-miR-642a hsa-miR-3194-5p hsa-miR-15a hsa-miR-1258 hsa-miR-128 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RIMS3
    Predesigned siRNA for gene silencing in human, mouse, rat RIMS3
    Clone
    Products:
         
    OriGene clones in human, mouse for RIMS3 (see all 6)
    OriGene ORF clones in mouse, rat for RIMS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIMS3 (NM_014747)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIMS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIMS3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RIMS3
    OriGene qSTAR qPCR primer pairs in human, mouse for RIMS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIMS3
      QuantiTect SYBR Green Assays in human, mouse, rat RIMS3
      QuantiFast Probe-based Assays in human, mouse, rat RIMS3

    Additional mRNA sequence: 

    AY326956.1 BC003103.1 D87074.1 

    2 DOTS entries:

    DT.413753  DT.91748411 

    Selected AceView cDNA sequences (see all 102):

    BP362770 AU120066 BM053119 AY326956 BI820965 AI346380 BU681931 AI274884 
    BE261795 D87074 BU848876 CR619233 AA626438 BM478119 AA456423 BE397286 
    BE312243 BQ721347 AW291735 BC003103 BQ064934 BU930896 NM_014747 BU156647 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RIMS3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                        
    SP2:              -                                                         
    SP3:                                                                        


    ECgene alternative splicing isoforms for RIMS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RIMS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAAAGTCA
    RIMS3 Expression
    About this image


    RIMS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Globus Pallidus   
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Lymph (Hematopoietic System)
    RIMS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RIMS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654808
        Custom PCR Arrays for RIMS3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RIMS3
    OriGene qSTAR qPCR primer pairs in human, mouse for RIMS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIMS3
    QuantiTect SYBR Green Assays in human, mouse, rat RIMS3
    QuantiFast Probe-based Assays in human, mouse, rat RIMS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RIMS3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rims31 , 5 regulating synaptic membrane exocytosis 31, 5 90.34(n)1
    98.05(a)1
      4 (56.58 cM)5
    2426621  NM_182929.21  NP_891559.11 
     1208548165 
    chicken
    (Gallus gallus)
    Aves RIMS31 regulating synaptic membrane exocytosis 3 79.61(n)
    81.58(a)
      428226  XM_004947787.1  XP_004947844.1 
    lizard
    (Anolis carolinensis)
    Reptilia RIMS36
    regulating synaptic membrane exocytosis 3
    79(a)
    1 ↔ 1
    GL343308.1(133429-181313)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rims31 regulating synaptic membrane exocytosis 3 75.55(n)
    83.88(a)
      779946  NM_001079023.1  NP_001072491.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rims31 regulating synaptic membrane exocytosis 3 74.02(n)
    79.93(a)
      563414  NM_001100009.2  NP_001093479.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rim6
    Rim
    4(a)
    1 → many
    3R(13698470-13742300)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-106
    Protein UNC-10, isoform a
    7(a)
    1 → many
    X(7272324-7280320) WBGene00006750


    ENSEMBL Gene Tree for RIMS3 (if available)
    TreeFam Gene Tree for RIMS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RIMS3 gene
    RIMS12  RIMS22  RIMS42  
    3 SIMAP similar genes for RIMS3 using alignment to 2 protein entries:     RIMS3_HUMAN (see all proteins):
    RIMS2    RIMS4    RIMS1

    Find genes that share paralogs with RIMS3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RIMS3 (see all 886)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120593051,2
    C,F,H--41085926(+) ATCAGG/ATGTGG 1 -- ds500117Minor allele frequency- A:0.12NS EA NA CSA WA 2222
    rs1821517071,2
    --41085937(+) CTGCAA/GTAAGC 1 -- ds50010--------
    rs1116140241,2
    C--41085967(+) GAGCTA/GCTGGA 1 -- ds50010--------
    rs1868313121,2
    --41086014(+) AGCTGC/TGGCCT 1 -- ds50010--------
    rs1379511231,2
    --41086045(+) CTGTCA/GTTGGA 1 -- ds50010--------
    rs1492057891,2
    --41086077(+) AAGTAG/TAAGGC 1 -- ds50010--------
    rs1379700631,2
    --41086116(+) GAGAC-/AGAGCC 1 -- ds50010--------
    rs121257241,2
    C,F,A,H--41086224(+) ATGCTC/TTTTTT 1 -- ds500133Minor allele frequency- T:0.48NS EA NA WA CSA 3376
    rs1133188011,2
    C--41086351(+) ATGAAA/TCCATT 1 -- ds50010--------
    rs1160963481,2
    C,F--41086396(+) ATACTG/TTACAT 1 -- ut311Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for RIMS3 (41086351 - 41131329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RIMS3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747397CNV Deletion23290073
    nsv599CNV Loss18451855

    Human Gene Mutation Database (HGMD): RIMS3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RIMS3
    DNA2.0 Custom Variant and Variant Library Synthesis for RIMS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611600    OMIM disorders: --


    Find genes that share disorders with RIMS3           About GenesLikeMe

    Genetic Association Database (GAD): RIMS3
    Human Genome Epidemiology (HuGE) Navigator: RIMS3 (1 document)

    Export disorders for RIMS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RIMS3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RIMS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. (PubMed id 12620390)1, 2, 3 Wang Y. and Suedhof T.C. (Genomics 2003)
    2. A de novo 1p34.2 microdeletion identifies the synaptic vesicle gene RIMS3 as a novel candidate for autism. (PubMed id 19546099)1, 4 Kumar R.A....Dobyns W.B. (J. Med. Genet. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. (PubMed id 10748113)1, 3 Wang Y....Sudhof T.C. (J. Biol. Chem. 2000)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: effects of antipsychotic drugs. (PubMed id 18490030)1 Weidenhofer J....Tooney P.A. (J Psychiatr Res 2009)
    9. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (Science 2007)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9783 HGNC: 21292 AceView: RIMS3 Ensembl:ENSG00000117016 euGenes: HUgn9783
    ECgene: RIMS3 H-InvDB: RIMS3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0137 KIAA0237

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RIMS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RIMS3 gene:
    Search GeneIP for patents involving RIMS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RIMS3   OriGene RNAi products in human, mouse, rat for RIMS3  
     OriGene qPCR primer pairs and template standards for RIMS3   OriGene Protein Over-expression Lysate for RIMS3  
     OriGene MassSpec something-or-other for RIMS3   OriGene clones in human, mouse for RIMS3  
     OriGene qSTAR qPCR primer pairs in human, mouse for RIMS3   OriGene Purified Protein for RIMS3  
     OriGene ORF clones in mouse, rat for RIMS3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RIMS3   OriGene Custom Protein Services for RIMS3  

     
     
     Block miRNA regulation of human, mouse, rat RIMS3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RIMS3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIMS3 Predesigned siRNA for gene silencing in human, mouse, rat RIMS3
     QuantiFast Probe-based Assays in human, mouse, rat RIMS3 QuantiTect SYBR Green Assays in human, mouse, rat RIMS3
     Custom PCR Arrays for RIMS3 Search Chromatin IP Primers for RIMS3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIMS3  Search GeneGlobe Interaction Network for RIMS3
     Regulatory tfbs in RIMS3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RIMS3 GenScript cDNA clones with any tag delivered in your preferred vector for RIMS3
     GenScript Custom Assay Services for RIMS3 GenScript Custom overexpressing Cell Line Services for RIMS3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RIMS3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RIMS3 antibodies
     RIMS3 proteins
     RIMS3 lysates
     Antibodies for RIMS3
     See all of Abcam's Antibodies, Kits and Proteins for RIMS3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RIMS3
     Antibodies for RIMS3
     ELISAs for RIMS3
     CLIAs for RIMS3



     Browse ESI BIO Cell Lines and PureStem Progenitors for RIMS3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMS3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RIMS3
     SwitchGear Promoter luciferase reporter plasmids for RIMS3
     ThermoFisher Antibodies for RIMS3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIMS3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RIMS3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RIMS3
     LSBio Antibodies in human, mouse, rat for RIMS3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RIMS3
      Search eBioscience for proteins for RIMS3
      Search eBioscience for elisas for RIMS3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RIMS3 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4