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Aliases for RIMS2 Gene

Aliases for RIMS2 Gene

  • Regulating Synaptic Membrane Exocytosis 2 2 3
  • RIM2 3 4 6
  • Rab-3-Interacting Molecule 2 3 4
  • Rab-3-Interacting Protein 3 3 4
  • RAB3 Interacting Protein 3 2 3
  • KIAA0751 4 6
  • RAB3IP3 3 4
  • RIM 2 3 4
  • OBOE 3 6
  • Regulating Synaptic Membrane Exocytosis Protein 2 3
  • Non-Small Cell Lung Cancer RimL3a Protein 3
  • Non-Small Cell Lung Cancer RimL3c Protein 3
  • Rab3-Interacting Molecule 2 3
  • Rab3-Interacting Protein 3
  • Nuclear Protein 3

External Ids for RIMS2 Gene

Previous HGNC Symbols for RIMS2 Gene

  • RAB3IP3

Previous GeneCards Identifiers for RIMS2 Gene

  • GC08P103836
  • GC08P104899
  • GC08P104182
  • GC08P104469
  • GC08P104582
  • GC08P099713

Summaries for RIMS2 Gene

GeneCards Summary for RIMS2 Gene

RIMS2 (Regulating Synaptic Membrane Exocytosis 2) is a Protein Coding gene. Diseases associated with RIMS2 include lung cancer. Among its related pathways are Insulin secretion. GO annotations related to this gene include ion channel binding and Rab GTPase binding. An important paralog of this gene is RIMS4.

UniProtKB/Swiss-Prot for RIMS2 Gene

  • Rab effector involved in exocytosis. May act as scaffold protein

Gene Wiki entry for RIMS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMS2 Gene

Genomics for RIMS2 Gene

Regulatory Elements for RIMS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIMS2 Gene

103,500,198 bp from pter
104,256,094 bp from pter
755,897 bases
Plus strand

Genomic View for RIMS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMS2 Gene

Proteins for RIMS2 Gene

  • Protein details for RIMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulating synaptic membrane exocytosis protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KX91
    • F8WD47
    • O43413
    • Q86XL9
    • Q8IWV9
    • Q8IWW1

    Protein attributes for RIMS2 Gene

    1411 amino acids
    Molecular mass:
    160403 Da
    Quaternary structure:
    • Interacts with RAB3A and RAB3B that have been activated by GTP-binding. Interacts with RAB3C, RAB3D and RAB26. Interacts with BZRAP1/RIMBP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2 (By similarity).
    • Sequence=BAA34471.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIMS2 Gene

    Alternative splice isoforms for RIMS2 Gene

neXtProt entry for RIMS2 Gene

Proteomics data for RIMS2 Gene at MOPED

Post-translational modifications for RIMS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RIMS2 Gene

Domains for RIMS2 Gene

Gene Families for RIMS2 Gene

Suggested Antigen Peptide Sequences for RIMS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Contains 1 FYVE-type zinc finger.
  • Contains 2 C2 domains.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 RabBD (Rab-binding) domain.
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with RIMS2: view

Function for RIMS2 Gene

Molecular function for RIMS2 Gene

UniProtKB/Swiss-Prot Function:
Rab effector involved in exocytosis. May act as scaffold protein

Gene Ontology (GO) - Molecular Function for RIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0017137 Rab GTPase binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0044325 ion channel binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RIMS2: view
genes like me logo Genes that share phenotypes with RIMS2: view

Animal Models for RIMS2 Gene

MGI Knock Outs for RIMS2:

Animal Model Products

CRISPR Products

miRNA for RIMS2 Gene

miRTarBase miRNAs that target RIMS2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIMS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RIMS2 Gene

Localization for RIMS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIMS2 Gene

Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for RIMS2 Gene COMPARTMENTS Subcellular localization image for RIMS2 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IEA --
GO:0042734 presynaptic membrane IEA --
GO:0043234 protein complex IEA --
GO:0045202 synapse --
GO:0048786 presynaptic active zone TAS 15217342
genes like me logo Genes that share ontologies with RIMS2: view

Pathways for RIMS2 Gene

SuperPathways for RIMS2 Gene

Superpath Contained pathways
1 Insulin secretion
genes like me logo Genes that share pathways with RIMS2: view

Pathways by source for RIMS2 Gene

1 KEGG pathway for RIMS2 Gene

Gene Ontology (GO) - Biological Process for RIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0010628 positive regulation of gene expression ISS --
GO:0017156 calcium ion-dependent exocytosis ISS --
GO:0017157 regulation of exocytosis ISS --
GO:0019933 cAMP-mediated signaling ISS --
genes like me logo Genes that share ontologies with RIMS2: view

Drugs for RIMS2 Gene

(1) HMDB Compounds for RIMS2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RIMS2: view

Transcripts for RIMS2 Gene

Unigene Clusters for RIMS2 Gene

Regulating synaptic membrane exocytosis 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIMS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIMS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1: - - -
SP2: - - - -

ExUns: 25a · 25b

Relevant External Links for RIMS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIMS2 Gene

mRNA expression in normal human tissues for RIMS2 Gene

mRNA differential expression in normal tissues according to GTEx for RIMS2 Gene

This gene is overexpressed in Adrenal Gland (5.4), Brain - Amygdala (5.4), Brain - Frontal Cortex (BA9) (5.1), Brain - Cortex (5.0), Brain - Putamen (basal ganglia) (4.7), and Brain - Anterior cingulate cortex (BA24) (4.7).

Protein differential expression in normal tissues for RIMS2 Gene

This gene is overexpressed in Vitreous humor (56.3) and Plasma (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RIMS2 Gene

SOURCE GeneReport for Unigene cluster for RIMS2 Gene Hs.655271

genes like me logo Genes that share expressions with RIMS2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for RIMS2 Gene

Orthologs for RIMS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIMS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RIMS2 35
  • 92.62 (n)
  • 95.25 (a)
RIMS2 36
  • 79 (a)
(Mus musculus)
Mammalia Rims2 35
  • 88.87 (n)
  • 93.7 (a)
Rims2 16
Rims2 36
  • 79 (a)
(Pan troglodytes)
Mammalia RIMS2 35
  • 99.68 (n)
  • 99.7 (a)
RIMS2 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Rims2 35
  • 89.76 (n)
  • 94.6 (a)
(Bos Taurus)
Mammalia RIMS2 36
  • 79 (a)
(Monodelphis domestica)
Mammalia RIMS2 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
-- 36
  • 64 (a)
-- 36
  • 98 (a)
-- 36
  • 87 (a)
-- 36
  • 92 (a)
(Gallus gallus)
Aves RIMS2 35
  • 84.91 (n)
  • 92.66 (a)
RIMS2 36
  • 77 (a)
(Anolis carolinensis)
Reptilia RIMS2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rims2 35
  • 79.36 (n)
  • 86.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15988 35
(Danio rerio)
Actinopterygii zgc73064 35
rims1b 36
  • 49 (a)
RIMS2 (4 of 5) 36
  • 61 (a)
RIMS2 (5 of 5) 36
  • 83 (a)
rims2a 36
  • 66 (a)
rims2b 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rim 37
  • 61 (a)
Rim 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea unc-10 37
  • 47 (a)
unc-10 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1713 36
  • 31 (a)
Species with no ortholog for RIMS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIMS2 Gene

Gene Tree for RIMS2 (if available)
Gene Tree for RIMS2 (if available)

Paralogs for RIMS2 Gene

Paralogs for RIMS2 Gene

genes like me logo Genes that share paralogs with RIMS2: view

Variants for RIMS2 Gene

Sequence variations from dbSNP and Humsavar for RIMS2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs769134 -- 103,641,216(-) CCAAG(A/C)AATGT intron-variant
rs919080 -- 103,717,271(-) TTTTT(C/T)TACTA intron-variant
rs978825 -- 103,841,439(-) ACCGA(G/T)ACAGA intron-variant
rs985728 -- 104,217,381(+) ctccc(A/G)cctca intron-variant
rs1024875 -- 103,629,067(-) GCTGA(A/C/G)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIMS2 Gene

Variant ID Type Subtype PubMed ID
esv275553 CNV Loss 21479260
esv1006039 CNV Deletion 20482838
esv2668771 CNV Deletion 23128226
esv28217 CNV Loss 19812545
esv270976 CNV Insertion 20981092
esv2660009 CNV Deletion 23128226
esv26529 CNV Loss 19812545
nsv831415 CNV Loss 17160897
dgv7841n71 CNV Loss 21882294
nsv465753 CNV Loss 19166990
nsv819897 CNV Loss 19587683
esv24057 CNV Gain 19812545
nsv891250 CNV Loss 21882294
esv2528242 CNV Deletion 19546169
nsv891251 CNV Gain 21882294
esv32618 CNV Loss 17666407
nsv6336 CNV Insertion 18451855
nsv891252 CNV Gain 21882294
nsv831416 CNV Gain 17160897

Relevant External Links for RIMS2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIMS2 Gene

Disorders for RIMS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RIMS2 Gene in MalaCards »

(1) Disease for RIMS2 Gene

Relevant External Links for RIMS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RIMS2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RIMS2 Gene

Publications for RIMS2 Gene

  1. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PMID: 12578829) Fukuda M. (J. Biol. Chem. 2003) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. (PMID: 12620390) Wang Y. … Suedhof T.C. (Genomics 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for RIMS2 Gene

Sources for RIMS2 Gene

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