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Aliases for RIMS2 Gene

Aliases for RIMS2 Gene

  • Regulating Synaptic Membrane Exocytosis 2 2 3 5
  • Rab-3-Interacting Molecule 2 3 4
  • Rab-3-Interacting Protein 3 3 4
  • RAB3 Interacting Protein 3 2 3
  • RAB3IP3 3 4
  • RIM 2 3 4
  • RIM2 3 4
  • Regulating Synaptic Membrane Exocytosis Protein 2 3
  • Non-Small Cell Lung Cancer RimL3a Protein 3
  • Non-Small Cell Lung Cancer RimL3c Protein 3
  • Rab3-Interacting Molecule 2 3
  • Rab3-Interacting Protein 3
  • Nuclear Protein 3
  • KIAA0751 4
  • OBOE 3

External Ids for RIMS2 Gene

Previous HGNC Symbols for RIMS2 Gene

  • RAB3IP3

Previous GeneCards Identifiers for RIMS2 Gene

  • GC08P103836
  • GC08P104899
  • GC08P104182
  • GC08P104469
  • GC08P104582
  • GC08P099713

Summaries for RIMS2 Gene

GeneCards Summary for RIMS2 Gene

RIMS2 (Regulating Synaptic Membrane Exocytosis 2) is a Protein Coding gene. Diseases associated with RIMS2 include Focal Hand Dystonia and Dravet Syndrome. Among its related pathways are Insulin secretion. GO annotations related to this gene include protein heterodimerization activity and ion channel binding. An important paralog of this gene is RIMS1.

UniProtKB/Swiss-Prot for RIMS2 Gene

  • Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Wiki entry for RIMS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMS2 Gene

Genomics for RIMS2 Gene

Regulatory Elements for RIMS2 Gene

Enhancers for RIMS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F103498 1 ENCODE 26.8 -0.3 -263 4.2 PKNOX1 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF548 ZNF263 SP3 RIMS2 LOC105375690 SLC25A32 BAALC-AS2 BAALC-AS1 ENSG00000271830
GH08F103645 0.6 ENCODE 26.9 +146.0 146043 2.0 ZFHX2 ZNF766 TAL1 BHLHE40 USF2 EGR2 RIMS2 LOC105375690 TARBP2P1 PIR62735
GH08F103900 0.4 ENCODE 19.2 +402.5 402492 4.8 MAFK RIMS2 LOC105375690 LOC105375689 ENSG00000239344
GH08F103788 0.4 Ensembl 17.1 +288.3 288307 0.5 ATF1 ZNF24 RIMS2 LOC105375690 ENSG00000239344 LOC105375689
GH08F104277 1.1 FANTOM5 ENCODE 5.2 +778.0 778045 1.8 MXI1 SIN3A ASH2L BMI1 EBF1 RELA YY1 CBX5 EED CREM RIMS2 LRP12 PIR34879 DCSTAMP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIMS2 on UCSC Golden Path with GeneCards custom track

Promoters for RIMS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001398315 -242 3600 PKNOX1 SIN3A FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF548 ZNF263 SP3

Genomic Location for RIMS2 Gene

103,500,642 bp from pter
104,256,094 bp from pter
755,453 bases
Plus strand

Genomic View for RIMS2 Gene

Genes around RIMS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIMS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIMS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMS2 Gene

Proteins for RIMS2 Gene

  • Protein details for RIMS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulating synaptic membrane exocytosis protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KX91
    • F8WD47
    • O43413
    • Q86XL9
    • Q8IWV9
    • Q8IWW1

    Protein attributes for RIMS2 Gene

    1411 amino acids
    Molecular mass:
    160403 Da
    Quaternary structure:
    • Interacts with RAB3A and RAB3B that have been activated by GTP-binding. Interacts with RAB3C, RAB3D and RAB26. Interacts with TSPOAP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2 (By similarity).
    • Sequence=BAA34471.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIMS2 Gene

    Alternative splice isoforms for RIMS2 Gene

neXtProt entry for RIMS2 Gene

Post-translational modifications for RIMS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RIMS2

No data available for DME Specific Peptides for RIMS2 Gene

Domains & Families for RIMS2 Gene

Suggested Antigen Peptide Sequences for RIMS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 C2 domains.
  • Contains 1 FYVE-type zinc finger.
  • Contains 2 C2 domains.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 RabBD (Rab-binding) domain.
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with RIMS2: view

Function for RIMS2 Gene

Molecular function for RIMS2 Gene

UniProtKB/Swiss-Prot Function:
Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Gene Ontology (GO) - Molecular Function for RIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0017137 Rab GTPase binding IEA --
GO:0044325 ion channel binding ISS,IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RIMS2: view
genes like me logo Genes that share phenotypes with RIMS2: view

Animal Models for RIMS2 Gene

MGI Knock Outs for RIMS2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIMS2 Gene

Localization for RIMS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIMS2 Gene

Cell membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIMS2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0042734 presynaptic membrane IEA --
genes like me logo Genes that share ontologies with RIMS2: view

Pathways & Interactions for RIMS2 Gene

SuperPathways for RIMS2 Gene

SuperPathway Contained pathways
1 Insulin secretion
genes like me logo Genes that share pathways with RIMS2: view

Pathways by source for RIMS2 Gene

1 KEGG pathway for RIMS2 Gene

Interacting Proteins for RIMS2 Gene

Gene Ontology (GO) - Biological Process for RIMS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0010628 positive regulation of gene expression ISS --
GO:0017156 calcium ion regulated exocytosis ISS --
GO:0017157 regulation of exocytosis IEA,ISS --
GO:0019933 cAMP-mediated signaling ISS --
genes like me logo Genes that share ontologies with RIMS2: view

No data available for SIGNOR curated interactions for RIMS2 Gene

Drugs & Compounds for RIMS2 Gene

(1) Drugs for RIMS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIMS2: view

Transcripts for RIMS2 Gene

Unigene Clusters for RIMS2 Gene

Regulating synaptic membrane exocytosis 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIMS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1: - - -
SP2: - - - -

ExUns: 25a · 25b

Relevant External Links for RIMS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIMS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RIMS2 Gene

mRNA differential expression in normal tissues according to GTEx for RIMS2 Gene

This gene is overexpressed in Adrenal Gland (x5.4), Brain - Amygdala (x5.4), Brain - Frontal Cortex (BA9) (x5.1), Brain - Cortex (x5.0), Brain - Putamen (basal ganglia) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Protein differential expression in normal tissues from HIPED for RIMS2 Gene

This gene is overexpressed in Vitreous humor (56.3) and Plasma (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RIMS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIMS2 Gene:


SOURCE GeneReport for Unigene cluster for RIMS2 Gene:


mRNA Expression by UniProt/SwissProt for RIMS2 Gene:

Tissue specificity: Expressed in melanocytes (PubMed:23999003).
genes like me logo Genes that share expression patterns with RIMS2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for RIMS2 Gene

Orthologs for RIMS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIMS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RIMS2 34 35
  • 99.68 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
-- 35
  • 92 (a)
-- 35
  • 87 (a)
-- 35
  • 64 (a)
-- 35
  • 51 (a)
(Canis familiaris)
Mammalia RIMS2 34 35
  • 92.62 (n)
(Rattus norvegicus)
Mammalia Rims2 34
  • 89.76 (n)
(Mus musculus)
Mammalia Rims2 34 16 35
  • 88.87 (n)
(Bos Taurus)
Mammalia RIMS2 35
  • 79 (a)
(Monodelphis domestica)
Mammalia RIMS2 35
  • 74 (a)
(Gallus gallus)
Aves RIMS2 34 35
  • 84.91 (n)
(Anolis carolinensis)
Reptilia RIMS2 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rims2 34
  • 79.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15988 34
(Danio rerio)
Actinopterygii RIMS2 (5 of 5) 35
  • 83 (a)
rims2a 35
  • 66 (a)
RIMS2 (4 of 5) 35
  • 61 (a)
rims1b 35
  • 49 (a)
rims2b 35
  • 35 (a)
zgc73064 34
fruit fly
(Drosophila melanogaster)
Insecta Rim 36 35
  • 61 (a)
(Caenorhabditis elegans)
Secernentea unc-10 36 35
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1713 35
  • 31 (a)
Species where no ortholog for RIMS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIMS2 Gene

Gene Tree for RIMS2 (if available)
Gene Tree for RIMS2 (if available)

Paralogs for RIMS2 Gene

Paralogs for RIMS2 Gene

genes like me logo Genes that share paralogs with RIMS2: view

Variants for RIMS2 Gene

Sequence variations from dbSNP and Humsavar for RIMS2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1005684 -- 104,157,127(+) AAATA(C/T)TGAAT intron-variant
rs1005685 -- 104,157,222(+) GTTAA(C/T)ATTAT intron-variant
rs10086112 -- 104,041,128(+) TAGTA(A/G)CAAAA intron-variant
rs10086186 -- 103,835,359(+) gcctc(C/T)caaag intron-variant
rs10086223 -- 104,041,155(+) TCTTA(C/T)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIMS2 Gene

Variant ID Type Subtype PubMed ID
esv2762762 CNV gain 21179565
esv28217 CNV loss 19812545
esv32618 CNV loss 17666407
esv3306700 CNV mobile element insertion 20981092
esv3326120 CNV insertion 20981092
esv3337196 CNV insertion 20981092
esv3349588 CNV insertion 20981092
esv3413230 CNV insertion 20981092
esv3572927 CNV loss 25503493
esv3618254 CNV loss 21293372
esv3618255 CNV loss 21293372
esv3618262 CNV gain 21293372
esv3618265 CNV loss 21293372
esv3618266 CNV loss 21293372
esv3618268 CNV gain 21293372
esv3618269 CNV loss 21293372
esv3891453 CNV gain 25118596
nsv1031195 CNV loss 25217958
nsv1151282 CNV duplication 26484159
nsv465753 CNV loss 19166990
esv275553 CNV loss 21479260
esv2668771 CNV deletion 23128226
esv2660009 CNV deletion 23128226
esv26529 CNV loss 19812545
esv2528242 CNV deletion 19546169
esv24057 CNV gain 19812545
esv1006039 CNV deletion 20482838
dgv7279n100 CNV gain 25217958
dgv1409e214 CNV loss 21293372
nsv971691 CNV duplication 23825009
nsv831416 CNV gain 17160897
nsv831415 CNV loss 17160897
nsv819897 CNV loss 19587683
nsv6336 CNV insertion 18451855
nsv611835 CNV loss 21841781
nsv611834 CNV loss 21841781
nsv611833 CNV loss 21841781
nsv483082 CNV loss 15286789
nsv475930 CNV novel sequence insertion 20440878

Variation tolerance for RIMS2 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.53; 85.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIMS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIMS2 Gene

Disorders for RIMS2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RIMS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
focal hand dystonia
  • organic writer's cramp
dravet syndrome
  • dravet syndrome, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search RIMS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RIMS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RIMS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIMS2 Gene

Publications for RIMS2 Gene

  1. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. (PMID: 12578829) Fukuda M. (J. Biol. Chem. 2003) 2 3 22 64
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. (PMID: 23999003) Yoo J.C. … Yoon T.J. (J. Dermatol. Sci. 2013) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction. (PMID: 20520587) Nielsen D.A. … Kreek M.J. (Psychiatr. Genet. 2010) 3 46 64

Products for RIMS2 Gene

Sources for RIMS2 Gene

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