Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RIMKLB Gene

protein-coding GIFtS: 46
GCID: GC12P008851

ribosomal modification protein rimK-like family member B

(Previous names: family with sequence similarity 80, member B )
(Previous symbol: FAM80B)

Search for RIMKLB
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribosomal Modification Protein RimK-Like Family Member B¹ ²		N-Acetyl-Aspartyl-Glutamate Synthetase B² ³
FAM80B¹ ² ³		NAAG Synthetase B² ³
NAAGS¹ ² ³		Beta-Citryl-Glutamate Synthase B²
NAAGS-I¹ ²		Beta-Citrylglutamate Synthase B²
Family With Sequence Similarity 80, Member B¹ ²		N-Acetylaspartyl-Glutamate Synthetase B²
KIAA1238¹ ³		EC 6.3.2.N6¹
Ribosomal Protein S6 Modification-Like Protein B² ³

External Ids:	HGNC: 29228¹	Entrez Gene: 57494²	Ensembl: ENSG00000166532⁷	OMIM: 614054⁵	UniProtKB: Q9ULI2³

Export aliases for RIMKLB gene to outside databases

Previous GC identifers: GC12P008743 GC12P008632

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RIMKB_HUMAN, Q9ULI2

Function: Catalyzes the synthesis of beta-citryl-glutamate and N-acetyl-aspartyl-glutamate. Beta-citryl-glutamate is

synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RIMKLB gene promoter:
RFX1 AML1a HFH-1 GCNF GCNF-1 HSF2 Nkx2-5 MIF-1 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RIMKLB promoter sequence

Search SABiosciences Chromatin IP Primers for RIMKLB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIMKLB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

RIMKLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIMKLB gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P008851: view genomic region (about GC identifiers)

Start:	8,834,196 bp from pter	End:	8,935,691 bp from pter
Size:	101,496 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RIMKB_HUMAN, Q9ULI2 (See protein sequence)

Recommended Name: Beta-citryl-glutamate synthase B

Size: 386 amino acids; 42464 Da

Cofactor: Binds 2 manganese ions per subunit (By similarity)

Subcellular location: Cytoplasm (By similarity)

Miscellaneous: N-acetylaspartyl-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous

system (CNS). Beta-citryl-L-glutamate, a structural analog of NAAG, is present in testis and immature brain (By

similarity)

Sequence caution: Sequence=BAA86552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B7Z834 D3DUV2 Q8N4P4 Q8WTW6

Alternative splicing: 2 isoforms: Q9ULI2-1 Q9ULI2-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RIMKLB: NX_Q9ULI2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9ULI2

RIMKLB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065785.2

ENSEMBL proteins:

ENSP00000438004 ENSP00000444445 ENSP00000439079 ENSP00000444721 ENSP00000445863

ENSP00000440943 ENSP00000350136

Human Recombinant Protein Products for RIMKLB:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for RIMKLB
	GenScript Custom Purified and Recombinant Proteins Services for RIMKLB
	Novus Biologicals RIMKLB Protein Novus Biologicals RIMKLB Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RIMKLB

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--

RIMKLB for ontologies About GeneDecksing

RIMKLB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RIMKLB
	GenScript Custom Superior Antibodies Services for RIMKLB
	Novus Biologicals RIMKLB Antibodies
	Abcam antibodies for RIMKLB
	Uscn Antibodies for RIMKLB
	ThermoFisher Antibody for RIMKLB

Assay Products for RIMKLB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RIMKLB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RIMKLB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RIMKLB for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR013651 ATP-grasp_RimK-type

IPR016185 PreATP-grasp_dom

IPR004666 RpS6_RimK/Lys_biosynth_LsyX

IPR011761 ATP-grasp

IPR013816 ATP_grasp_subdomain_2

Graphical View of Domain Structure for InterPro Entry Q9ULI2

ProtoNet protein and cluster: Q9ULI2

UniProtKB/Swiss-Prot: RIMKB_HUMAN, Q9ULI2

Similarity: Belongs to the RimK family

Similarity: Contains 1 ATP-grasp domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RIMKB_HUMAN, Q9ULI2

Function: Catalyzes the synthesis of beta-citryl-glutamate and N-acetyl-aspartyl-glutamate. Beta-citryl-glutamate is

synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity)

Catalytic activity: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate

Catalytic activity: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate

Enzyme Number (IUBMB): EC 6.3.2.n6¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005524	ATP binding	IEA	--
GO:0016879	ligase activity, forming carbon-nitrogen bonds	--	--
GO:0016881	acid-amino acid ligase activity	IEA	--
GO:0046872	metal ion binding	IEA	--
GO:0072590	N-acetyl-L-aspartate-L-glutamate ligase activity	ISS	--

RIMKLB for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RIMKLB

miRNA Products:		OriGene 3'-UTR Clone: RIMKLB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIMKLB
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate RIMKLB (see all 60):
		hsa-miR-26a-2* hsa-miR-136 hsa-miR-300 hsa-miR-429 hsa-miR-15a hsa-miR-3651 hsa-miR-624* hsa-miR-371-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIMKLB OriGene shRNA RFP: RIMKLB OriGene siRNA: RIMKLB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIMKLB
		Sirion Biotech Custom design and validation of potent shRNA sequences against RIMKLB

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RIMKLB
			Sirion Biotech Customized adenovirus for overexpression of RIMKLB Sirion Biotech Customized adenovirus for potent knockdown of RIMKLB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIMKLB (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIMKLB (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for RIMKLB
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIMKLB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIMKLB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RIMKLB
		Search LifeMap BioReagents cell lines for RIMKLB
		Sirion Biotech Customized stable knockdown cell line services for RIMKLB Sirion Biotech Customized inducible knockdown cell line services for RIMKLB Sirion Biotech Customized stable overexpressing cell line services for RIMKLB Sirion Biotech Customized inducible overexpressing cell line services for RIMKLB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMKLB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RIMKLB

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for RIMKLB (Q9ULI2³ ENSP00000350136⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
MTIF2	ENSP00000263629⁴	STRING: ENSP00000263629
EGR2	ENSP00000242480⁴	STRING: ENSP00000242480

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	cellular protein modification process	IEA	--

RIMKLB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RIMKLB

1 HMDB Compound for RIMKLB About this table

Compound	Synonyms	CAS #	PubMed Ids
Manganese	manganese	7439-96-5	--

Search CenterWatch for drugs/clinical trials and news about RIMKLB / RIMKB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RIMKLB gene:

NM_020734.2

Unigene Cluster for RIMKLB:

Ribosomal modification protein rimK-like family member B

Hs.504670 [show with all ESTs]

Unigene Representative Sequence: NM_020734

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000538758 ENST00000544257(uc009zgf.2) ENST00000541044 ENST00000539923

ENST00000537189 ENST00000535829 ENST00000299673 ENST00000538135 ENST00000542232

ENST00000504495(uc009zgg.2) ENST00000510357(uc001quy.3) ENST00000357529(uc001qux.2 uc010sgl.1 uc001quw.2)

miRNA Products:		OriGene 3'-UTR Clone: RIMKLB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIMKLB
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate RIMKLB (see all 60):
		hsa-miR-26a-2* hsa-miR-136 hsa-miR-300 hsa-miR-429 hsa-miR-15a hsa-miR-3651 hsa-miR-624* hsa-miR-371-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIMKLB OriGene shRNA RFP: RIMKLB OriGene siRNA: RIMKLB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIMKLB
		Sirion Biotech Custom design and validation of potent shRNA sequences against RIMKLB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIMKLB (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIMKLB (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for RIMKLB
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIMKLB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIMKLB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIMKLB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RIMKLB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIMKLB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIMKLB

Additional cDNA sequence:

AB033064.1 AK302847.1 AL137567.1 BC006368.2 BC015879.1 BC021977.2

16 DOTS entries:

DT.410028 DT.447067 DT.95260457 DT.40285923 DT.95231895 DT.121190094 DT.100751732 DT.121190155

DT.100683139 DT.100751731 DT.95267599 DT.95267600 DT.121190083 DT.91946754 DT.100778493 DT.95139537

24/256 AceView cDNA sequences (see all 256):

AI309288 AI300455 AI989773 CD722083 AL120456 AA905486 BG151502 BX503133

AA461269 AW196581 BF593829 AL137567 AW473377 CK902448 BQ924704 CB321852

BC006368 AW130287 AI949888 BI825153 AA737188 AI033333 BM667978 CB241627

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RIMKLB (see all 7) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c
SP1:
SP2:
SP3:			-
SP4:																							-
SP5:																							-

ECgene alternative splicing isoforms for RIMKLB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RIMKLB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACATACCAAG

About this image
See RIMKLB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIMKLB

SOURCE GeneReport for Unigene cluster: Hs.504670
SABiosciences Custom PCR Arrays for RIMKLB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIMKLB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RIMKLB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIMKLB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIMKLB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMKLB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for RIMKLB gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rimklb^{1 , 5}	ribosomal modification protein rimK-like family member more^{1, 5}	91.02(n)¹ 96.89(a)¹		6 (57.55 cM)⁵ 108653¹ NM_027664.1¹ NP_081940.1¹ 122447296⁵
chicken (Gallus gallus)	Aves	RIMKLB¹	ribosomal modification protein rimK-like family member more	83.42(n) 95.6(a)		418255 XM_416481.3 XP_416481.2
lizard (Anolis carolinensis)	Reptilia	RIMKLB⁶	--	96(a)	1 ↔ 1	2(81329232-81342499)
zebrafish (Danio rerio)	Actinopterygii	rimkla¹	ribosomal modification protein rimK-like family member more	67.45(n) 75.33(a)		447815 NM_001004554.2 NP_001004554.1
E. coli (Escherichia coli)	Gamma proteobacteria	rimK⁶	ribosomal protein S6 modification protein	24(a)	1 → many	Chromosome(891190-892092)

ENSEMBL Gene Tree for RIMKLB (if available)
TreeFam Gene Tree for RIMKLB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RIMKLB gene

RIMKLA²

1 SIMAP similar gene for RIMKLB using alignment to 5 protein entries: RIMKB_HUMAN (see all proteins):

RIMKLA

RIMKLB for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for RIMKLB
PGOHUM00000244422 PGOHUM00000239170

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7976729^1,2	C,F,A,H	--	8848685(+)	`NNNNCA/GGTTAC`	1	--	us2k¹		22		NS EA NA CSA WA	2314
rs71980368^1,2	C	--	8848736(+)	`TTAAT-/TAAA TATTA`	1	--	us2k¹		0	--	--	--	--
rs144176075^1,2	C	--	8848787(+)	`TTCAC-/TGTGTTT`	1	--	us2k¹		0	--	--	--	--
rs185956656^1,2		--	8848854(+)	`AAATGC/TTTCTC`	1	--	us2k¹		0	--	--	--	--
rs189941989^1,2		--	8848909(+)	`ATCAGA/CGTGGA`	1	--	us2k¹		0	--	--	--	--
rs6487333^1,2	C,F,A,H	--	8848929(+)	`CAACAA/TTTTAG`	1	--	us2k¹		20		NS EA NA CSA WA	1846
rs182675385^1,2		--	8848983(+)	`TCTTAC/TAGGGC`	1	--	us2k¹		0	--	--	--	--
rs151221101^1,2		--	8848987(+)	`ATAGGA/GCGTTT`	1	--	us2k¹		0	--	--	--	--
rs115192902^1,2	F	--	8849012(+)	`TGTAAA/GCCAAC`	1	--	us2k¹		1		WA	118
rs186638520^1,2		--	8849066(+)	`TAGCAC/TTAAAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RIMKLB (8834196 - 8935691 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for RIMKLB
6 CNVs: 66134 86187 86186 22595 71462 48016

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIMKLB

DNA2.0 Custom Variant and Variant Library Synthesis for RIMKLB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RIMKLB for disorders About MalaCards

RIMKLB for disorders About GeneDecksing

OMIM gene information: 614054 OMIM disorders: --

Export disorders for RIMKLB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RIMKLB gene integrated from 9 sources:
(articles sorted by number of sources associating them with RIMKLB)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2, 3} Nagase T.... Ohara O. (1999)
Molecular characterization of N-acetylaspartylglutama te synthetase. (PubMed id 20643647)^{1, 3} Becker I....Eckhardt M. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
N-acetylaspartylglutamate synthetase II synthesizes N -acetylaspartylglutamylglutamate. (PubMed id 21454531)¹ Lodder-Gadaczek J....Eckhardt M. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)¹ Emanuele M.J....Elledge S.J. (2011)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)¹ Matsumoto M....Nakayama K.I. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57494	HGNC: 29228	AceView: KIAA1238	Ensembl:ENSG00000166532	euGenes: HUgn57494
ECgene: RIMKLB	H-InvDB: RIMKLB

(According to HUGE)
About This Section

HUGE: KIAA1238

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RIMKLB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RIMKLB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RIMKLB gene:
Search GeneIP for patents involving RIMKLB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for RIMKLB
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIMKLB		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIMKLB
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RIMKLB		OriGene 3'-UTR Clone for RIMKLB
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIMKLB		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIMKLB
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RIMKLB		OriGene Custom Protein Services for RIMKLB
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RIMKLB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIMKLB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIMKLB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIMKLB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIMKLB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIMKLB

	GenScript Custom Purified and Recombinant Proteins Services for RIMKLB		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for RIMKLB
	GenScript Custom Assay Services for RIMKLB		GenScript Custom Superior Antibodies Services for RIMKLB
	GenScript Custom overexpressing Cell Line Services for RIMKLB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RIMKLB promoter
	Search Chromatin IP Primers for RIMKLB
	RT² qPCR Primer Assay in human, mouse, rat RIMKLB
	Search GNC Networks for RIMKLB
	SABiosciences Custom PCR Arrays for RIMKLB

Search Tocris compounds for RIMKLB

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RIMKLB antibodies
	RIMKLB proteins
	RIMKLB lysates

	Antibodies for RIMKLB
	See all of Abcam's Antibodies, Kits and Proteins for RIMKLB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RIMKLB Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RIMKLB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMKLB

	Browse SwitchGear 3'UTR luciferase reporter plasmids for RIMKLB
	SwitchGear Promoter luciferase reporter plasmids for RIMKLB

ThermoFisher Antibody for RIMKLB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIMKLB

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RIMKLB

Sirion Biotech Customized:

	stable knockdown cell line services for RIMKLB
	inducible knockdown cell line services for RIMKLB
	design and validation of potent shRNA sequences against RIMKLB
	adenovirus for potent knockdown of RIMKLB
	adenovirus for overexpression of RIMKLB
	stable overexpressing cell line services for RIMKLB
	inducible overexpressing cell line services for RIMKLB

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RIMKLB gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

RIMKLB Gene

ribosomal modification protein rimK-like family member B

Aliases
for RIMKLB gene

Summaries
for RIMKLB gene

Genomic Views
for RIMKLB gene

Proteins
for RIMKLB gene

Protein Domains /
Families
for RIMKLB gene

Function
for RIMKLB gene

Pathways & Interactions
for RIMKLB gene

Drugs & Compounds
for RIMKLB gene

Transcripts
for RIMKLB gene

Expression
for RIMKLB gene

Orthologs
for RIMKLB gene

Paralogs
for RIMKLB gene

Genomic Variants
for RIMKLB gene

Disorders / Diseases
for RIMKLB gene

Publications
for RIMKLB gene

External Searches for RIMKLB gene

Genome Databases showing RIMKLB gene

Other Databases showing RIMKLB gene

Specialized Databases showing RIMKLB gene

Intellectual Property
for RIMKLB gene

Products
for RIMKLB gene

View Random Gene

Advanced Search

Export list of displayed genes

RIMKLB Gene

ribosomal modification protein rimK-like family member B

Aliasesfor RIMKLB gene

Summariesfor RIMKLB gene

Genomic Viewsfor RIMKLB gene

Proteinsfor RIMKLB gene

Protein Domains /Familiesfor RIMKLB gene

Functionfor RIMKLB gene

Pathways & Interactionsfor RIMKLB gene

Drugs & Compoundsfor RIMKLB gene

Transcriptsfor RIMKLB gene

Expression for RIMKLB gene

Orthologsfor RIMKLB gene

Paralogsfor RIMKLB gene

Genomic Variantsfor RIMKLB gene

Disorders / Diseasesfor RIMKLB gene

Publicationsfor RIMKLB gene

External Searches for RIMKLB gene

Genome Databases showing RIMKLB gene

Other Databases showing RIMKLB gene

Specialized Databases showing RIMKLB gene

Intellectual Propertyfor RIMKLB gene

Productsfor RIMKLB gene

View Random Gene

Aliases
for RIMKLB gene

Summaries
for RIMKLB gene

Genomic Views
for RIMKLB gene

Proteins
for RIMKLB gene

Protein Domains /
Families
for RIMKLB gene

Function
for RIMKLB gene

Pathways & Interactions
for RIMKLB gene

Drugs & Compounds
for RIMKLB gene

Transcripts
for RIMKLB gene

Expression
for RIMKLB gene

Orthologs
for RIMKLB gene

Paralogs
for RIMKLB gene

Genomic Variants
for RIMKLB gene

Disorders / Diseases
for RIMKLB gene

Publications
for RIMKLB gene

Intellectual Property
for RIMKLB gene

Products
for RIMKLB gene