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RIMKLB Gene

protein-coding   GIFtS: 47
GCID: GC12P008851

Ribosomal Modification Protein RimK-Like Family Member B

(Previous names: family with sequence similarity 80, member B)
(Previous symbol: FAM80B)
  Search for RIMKLB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribosomal Modification Protein RimK-Like Family Member B1 2     N-Acetylaspartyl-Glutamate Synthetase1
FAM80B1 2 3     NAAGS-I2
NAAGS2 3 5     Beta-Citryl-Glutamate Synthase B2
Family With Sequence Similarity 80, Member B1 2     Beta-Citrylglutamate Synthase B2
Ribosomal Protein S6 Modification-Like Protein B2 3     N-Acetylaspartyl-Glutamate Synthetase B2
N-Acetyl-Aspartyl-Glutamate Synthetase B2 3     EC 6.3.2.n63
NAAG Synthetase B2 3     KIAA12383

External Ids:    HGNC: 292281   Entrez Gene: 574942   Ensembl: ENSG000001665327   OMIM: 6140545   UniProtKB: Q9ULI23   

Export aliases for RIMKLB gene to outside databases

Previous GC identifers: GC12P008743 GC12P008632


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RIMKLB Gene:
RIMKLB (ribosomal modification protein rimK-like family member B) is a protein-coding gene. GO annotations related to this gene include citrate-L-glutamate ligase activity and acid-amino acid ligase activity. An important paralog of this gene is RIMKLA.

UniProtKB/Swiss-Prot: RIMKB_HUMAN, Q9ULI2
Function: Catalyzes the synthesis of beta-citryl-glutamate and N-acetyl-aspartyl-glutamate. Beta-citryl-glutamate
is synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RIMKLB gene promoter:
         RFX1   AML1a   HFH-1   GCNF   GCNF-1   HSF2   Nkx2-5   MIF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RIMKLB promoter sequence
   Search Chromatin IP Primers for RIMKLB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIMKLB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

RIMKLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIMKLB gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P008851:  view genomic region     (about GC identifiers)

Start:
8,834,196 bp from pter      End:
8,935,691 bp from pter
Size:
101,496 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RIMKB_HUMAN, Q9ULI2 (See protein sequence)
Recommended Name: Beta-citryl-glutamate synthase B  
Size: 386 amino acids; 42464 Da
Cofactor: Binds 2 magnesium or manganese ions per subunit (By similarity)
Miscellaneous: N-acetylaspartyl-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central
nervous system (CNS). Beta-citryl-L-glutamate, a structural analog of NAAG, is present in testis and immature
brain (By similarity)
Sequence caution: Sequence=BAA86552.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B7Z834 D3DUV2 Q8N4P4 Q8WTW6
Alternative splicing: 2 isoforms:  Q9ULI2-1   Q9ULI2-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RIMKLB: NX_Q9ULI2

Explore proteomics data for RIMKLB at MOPED


See RIMKLB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_065785.2  
ENSEMBL proteins: 
 ENSP00000438004   ENSP00000444445   ENSP00000439079   ENSP00000444721   ENSP00000445863  
 ENSP00000440943   ENSP00000350136  

RIMKLB Human Recombinant Protein Products:

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Novus Biologicals RIMKLB Protein
Novus Biologicals RIMKLB Lysate
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Cloud-Clone Corp. Proteins for RIMKLB

 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):
 IPR013651 ATP-grasp_RimK-type
 IPR016185 PreATP-grasp_dom
 IPR004666 RpS6_RimK/Lys_biosynth_LsyX
 IPR011761 ATP-grasp
 IPR013815 ATP_grasp_subdomain_1

Graphical View of Domain Structure for InterPro Entry Q9ULI2

ProtoNet protein and cluster: Q9ULI2

UniProtKB/Swiss-Prot: RIMKB_HUMAN, Q9ULI2
Similarity: Belongs to the RimK family
Similarity: Contains 1 ATP-grasp domain


Find genes that share domains with RIMKLB           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RIMKB_HUMAN, Q9ULI2
Function: Catalyzes the synthesis of beta-citryl-glutamate and N-acetyl-aspartyl-glutamate. Beta-citryl-glutamate
is synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity)
Catalytic activity: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate
Catalytic activity: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate

     Enzyme Number (IUBMB): EC 6.3.2.n61

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004363glutathione synthase activity ----
GO:0005524ATP binding IEA--
GO:0016881acid-amino acid ligase activity ----
GO:0046872metal ion binding IEA--
GO:0072590N-acetyl-L-aspartate-L-glutamate ligase activity ISS--
     
Find genes that share ontologies with RIMKLB           About GenesLikeMe


Phenotypes:
     1 MGI phenotypic allele for Rimklb (no phenotypes)

Find genes that share phenotypes with RIMKLB           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Rimklbtm1(KOMP)Vlcg for RIMKLB

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RIMKLB
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RIMKLB

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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIMKLB

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate RIMKLB (see all 60):
hsa-miR-26a-2* hsa-miR-136 hsa-miR-300 hsa-miR-429 hsa-miR-15a hsa-miR-3651 hsa-miR-624* hsa-miR-371-5p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat RIMKLB

Gene Editing
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Clone
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OriGene ORF clones in mouse, rat for RIMKLB
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMKLB


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RIMKB_HUMAN, Q9ULI2: Cytoplasm (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ISS--

Find genes that share ontologies with RIMKLB           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RIMKLB
Interactions:

    Search GeneGlobe Interaction Network for RIMKLB

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for RIMKLB (Q9ULI23 ENSP000003501364) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
UCKL1ENSP000003461554STRING: ENSP00000346155
UPRTENSP000003624814STRING: ENSP00000362481
EGR2ENSP000002424804STRING: ENSP00000242480
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006464cellular protein modification process IEA--
GO:0006750glutathione biosynthetic process ----

Find genes that share ontologies with RIMKLB           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RIMKLB (RIMKB)

1 HMDB Compound for RIMKLB    About this table
CompoundSynonyms CAS #PubMed Ids
Manganesemanganese 7439-96-5--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RIMKLB gene: 
NM_020734.2  

Unigene Cluster for RIMKLB:

Ribosomal modification protein rimK-like family member B
Hs.504670  [show with all ESTs]
Unigene Representative Sequence: NM_020734
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000538758 ENST00000544257(uc009zgf.2) ENST00000541044 ENST00000539923
ENST00000537189 ENST00000535829 ENST00000299673 ENST00000538135 ENST00000542232
ENST00000504495(uc009zgg.2) ENST00000510357(uc001quy.3) ENST00000357529(uc001qux.2 uc010sgl.1 uc001quw.2)

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate RIMKLB (see all 60):
hsa-miR-26a-2* hsa-miR-136 hsa-miR-300 hsa-miR-429 hsa-miR-15a hsa-miR-3651 hsa-miR-624* hsa-miR-371-5p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat RIMKLB
Clone
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OriGene ORF clones in mouse, rat for RIMKLB
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Primer
Products:
    
OriGene qPCR primer pairs and template standards for RIMKLB
OriGene qSTAR qPCR primer pairs in human, mouse for RIMKLB
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIMKLB
  QuantiTect SYBR Green Assays in human, mouse, rat RIMKLB
  QuantiFast Probe-based Assays in human, mouse, rat RIMKLB

Additional mRNA sequence: 

AB033064.1 AK302847.1 AL137567.1 BC006368.2 BC015879.1 BC021977.2 

16 DOTS entries:

DT.410028  DT.447067  DT.95260457  DT.40285923  DT.95231895  DT.121190094  DT.100751732  DT.121190155 
DT.100683139  DT.100751731  DT.95267599  DT.95267600  DT.121190083  DT.91946754  DT.100778493  DT.95139537 

Selected AceView cDNA sequences (see all 256):

AI222766 BG151502 BF058716 AB033064 BX503133 AA461269 CK902448 AI084950 
AL137567 AL120456 AI949888 BM715627 AA725611 BQ065864 CR595615 AI918161 
BM677083 AW196581 BQ924704 AW130287 AA737188 BF593829 AI300455 CB321852 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RIMKLB (see all 7)    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c
SP1:                                                                                                
SP2:                                                                                                
SP3:        -                                                                                       
SP4:                                                                    -                           
SP5:                                                                    -                           


ECgene alternative splicing isoforms for RIMKLB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RIMKLB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACATACCAAG
RIMKLB Expression
About this image


RIMKLB expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 2 entries
         Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
 
 Testis (Reproductive System)
         XY Germ Cells Testis Cord
 
 Gonad
         XY Germ Cells Testis Cord
 
 Brain (Nervous System)
         Choroid Plexus Progenitor Cells Choroid Plexus
 
 Adipose (Muscoskeletal System)
RIMKLB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RIMKLB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.504670
    Custom PCR Arrays for RIMKLB
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QuantiFast Probe-based Assays in human, mouse, rat RIMKLB
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMKLB

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RIMKLB gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rimklb1 , 5 ribosomal modification protein rimK-like family member more1, 5 90.41(n)1
96.11(a)1
  6 (57.55 cM)5
1086531  NM_027664.11  NP_081940.11 
 1224472965 
chicken
(Gallus gallus)
Aves RIMKLB1 ribosomal modification protein rimK-like family member more 83.42(n)
95.6(a)
  418255  XM_416481.4  XP_416481.2 
lizard
(Anolis carolinensis)
Reptilia RIMKLB6
ribosomal modification protein rimK-like family me...
96(a)
1 ↔ 1
2(81329232-81364300)
tropical clawed frog
(Xenopus tropicalis)
Amphibia rimklb1 ribosomal modification protein rimK-like family member more 75.22(n)
88.22(a)
  100486701  XM_002941618.2  XP_002941664.1 
zebrafish
(Danio rerio)
Actinopterygii rimkla1 ribosomal modification protein rimK-like family member more 66.05(n)
74.28(a)
  447815  NM_001004554.2  NP_001004554.1 


ENSEMBL Gene Tree for RIMKLB (if available)
TreeFam Gene Tree for RIMKLB (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RIMKLB gene
RIMKLA2  
1 SIMAP similar gene for RIMKLB using alignment to 5 protein entries:     RIMKB_HUMAN (see all proteins):
RIMKLA

Find genes that share paralogs with RIMKLB           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for RIMKLB
PGOHUM00000244422 PGOHUM00000239170


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RIMKLB (see all 1693)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1432068241,2
C--8630472(+) TATCAC/TGCCTG 1 -- us2k10--------
rs79767291,2
C,F,A,H--8848685(+) GATGCA/GGTTAC 1 -- us2k122Minor allele frequency- G:0.12NS EA NA CSA WA 2314
rs719803681,2
C--8848736(+) TTAAT-/TAAA  
        
TATTA
1 -- us2k10--------
rs594910951,2
C--8848738(+) AATTA-/AATA  
        
TTATT
1 -- us2k10--------
rs1441760751,2
C--8848787(+) TTCAC-/TGTGTTT 1 -- us2k10--------
rs1859566561,2
--8848854(+) AAATGC/TTTCTC 1 -- us2k10--------
rs1899419891,2
--8848909(+) ATCAGA/CGTGGA 1 -- us2k10--------
rs64873331,2
C,F,A,H--8848929(+) CAACAA/TTTTAG 1 -- us2k120Minor allele frequency- T:0.14NS EA NA CSA WA 1846
rs1826753851,2
C--8848983(+) TCTTAC/TAGGGC 1 -- us2k10--------
rs1512211011,2
--8848987(+) ATAGGA/GCGTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RIMKLB (8834196 - 8935691 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for RIMKLB:    About this table    
Variant IDTypeSubtypePubMed ID
dgv261e199CNV Deletion23128226
nsv436155CNV Deletion17901297
esv26413CNV Loss19812545
esv22028CNV Loss19812545
esv34096CNV Loss18971310

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614054    OMIM disorders: --


Find genes that share disorders with RIMKLB           About GenesLikeMe


Export disorders for RIMKLB gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RIMKLB gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with RIMKLB)
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  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
  2. Molecular characterization of N-acetylaspartylglutamate synthetase. (PubMed id 20643647)1, 3 Becker I....Eckhardt M. (J. Biol. Chem. 2010)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  5. N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate. (PubMed id 21454531)1 Lodder-Gadaczek J....Eckhardt M. (J. Biol. Chem. 2011)
  6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  9. Large-scale analysis of the human ubiquitin-related proteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (Proteomics 2005)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
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  Query String
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NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57494 HGNC: 29228 AceView: KIAA1238 Ensembl:ENSG00000166532 euGenes: HUgn57494
ECgene: RIMKLB H-InvDB: RIMKLB

(According to HUGE)
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HUGE: KIAA1238

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RIMKLB Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RIMKLB gene:
Search GeneIP for patents involving RIMKLB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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