RIMKLA Gene
protein-coding GIFtS : 45
GCID: GC01 P042846
ribosomal modification protein rimK-like family member A (Previous names: family with sequence similarity 80, member A ) (Previous symbol: FAM80A )
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Aliasesfor RIMKLA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ribosomal Modification Protein RimK-Like Family Member A 1 2 NAAG Synthetase A2 3 FAM80A1 2 3 MGC478161 NAAGS-II1 2 RP11-157D18.11 Family With Sequence Similarity 80, Member A1 2 N-Acetylaspartyl-Glutamate Synthetase A2 Ribosomal Protein S6 Modification-Like Protein A2 3 N-Acetylaspartylglutamate Synthetase II2 NAAGS2 3 EC 6.3.2.N61
Export aliases for RIMKLA gene to outside databases Previous GC identifers: GC01P042620 GC01P040966
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Summariesfor RIMKLA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: RIMKA_HUMAN, Q8IXN7 Function : Catalyzes the synthesis of N-acetylaspartyl-glutamate (NAAG)
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Genomic Viewsfor RIMKLA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_032977.9 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RIMKLA gene promoter: Brachyury NRSF form 1 XBP-1 NRSF form 2 c-Ets-1 E47 AREB6 SRY Sox9 IRF-7A Other transcription factors Search SABiosciences Chromatin IP Primers for RIMKLA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIMKLA
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.2 RIMKLA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P042846: view genomic region
(about GC identifiers )
Start:
42,846,466 bp from pter
End:
42,889,900 bp from pter
Size:
43,435 bases
Orientation:
plus strand
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Proteinsfor RIMKLA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RIMKA_HUMAN, Q8IXN7 (See
protein sequence )Recommended Name: N-acetylaspartyl-glutamate synthetase A Size : 391 amino acids; 42864 Da
Cofactor : Binds 2 manganese ions per subunit (By similarity)
Subcellular location : Cytoplasm (Probable)
Miscellaneous : N-acetylaspartyl-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervoussystem (CNS) (By similarity)
Sequence caution : Sequence=AAH39737.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAH70661.1; Type=Erroneous gene model prediction;
Secondary accessions : Q5VUS5Explore the universe of human proteins at neXtProt for RIMKLA: NX_Q8IXN7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IXN7 RIMKLA Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_775913.2 ENSEMBL proteins: ENSP00000387064 ENSP00000414330 Human Recombinant Protein Products for RIMKLA: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
RIMKLA for ontologies About GeneDecksing RIMKLA Antibody Products: Assay Products for RIMKLA:
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Protein
Domains / Familiesfor RIMKLA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RIMKLA for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q8IXN7 ProtoNet protein and cluster: Q8IXN7
UniProtKB/Swiss-Prot: RIMKA_HUMAN, Q8IXN7 Similarity : Belongs to the RimK familySimilarity : Contains 1 ATP-grasp domain
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Functionfor RIMKLA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: RIMKA_HUMAN, Q8IXN7 Function : Catalyzes the synthesis of N-acetylaspartyl-glutamate (NAAG)Catalytic activity : ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate Enzyme Number (IUBMB): EC 6.3.2.n6 1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005524 ATP binding
IEA -- GO:0016879 ligase activity, forming carbon-nitrogen bonds
-- -- GO:0016881 acid-amino acid ligase activity
IEA -- GO:0046872 metal ion binding
IEA -- GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity
ISS --
RIMKLA for ontologies About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for RIMKLA :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RIMKLA (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RIMKLA (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RIMKLA (NM_173642 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIMKLA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RIMKLA
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMKLA
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Pathways & Interactionsfor RIMKLA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIMKLA STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)5/8 Interacting proteins for RIMKLA (ENSP00000414330 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 8 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006464 cellular protein modification process
IEA --
RIMKLA for ontologies About GeneDecksing
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Drugs & Compoundsfor RIMKLA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RIMKLA 1 HMDB Compound for RIMKLA About this table Compound Synonyms
CAS
# PubMed Ids Manganese manganese 7439-96-5 --
Search CenterWatch for drugs/clinical trials and news about RIMKLA / RIMKA
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Transcriptsfor RIMKLA gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RIMKLA gene: NM_173642.3 Unigene Cluster for RIMKLA:
Ribosomal modification protein rimK-like family member A Hs.420244 [show with all ESTs ] Unigene Representative Sequence: NM_173642 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000410070 ENST00000431473 (uc001chi.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RIMKLA (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RIMKLA (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: RIMKLA (NM_173642 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIMKLA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RIMKLA
Additional cDNA sequence: BC039737.1
9 DOTS entries : DT.410720 DT.97837726
DT.310105 DT.99982330 DT.404882 DT.108385 DT.92065637 DT.121458333 DT.91927766 24/47 AceView cDNA sequences (see all 47 ):
CB154467 BQ220020 AI681638 BE220489 AA932847 AA176636 BQ638856 BE669885 AI796946 AA595285 AA179690 BM796010 BE348543 CB146074 BE669736 BX108269 AA917494 BC039737 BM713339 AV724080 BU178521 AI279434 AW001564 BF971367 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for RIMKLA About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 SP1 :     -           SP2 :              
ECgene alternative splicing isoforms for RIMKLA
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Expression for RIMKLA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RIMKLA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGCCCGAACAbout this image RIMKLA expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Posterior foregut-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See RIMKLA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RIMKLA SOURCE GeneReport for Unigene cluster: Hs.420244 SABiosciences Custom PCR Arrays for RIMKLA Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RIMKLABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RIMKLA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RIMKLA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RIMKLA In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMKLA
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Orthologsfor RIMKLA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for RIMKLA gene from 2/11 species (see all 11 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
zebrafish (Danio rerio)
Actinopterygii
rimkla6
ribosomal modification protein rimK-like family me...
64(a)
1 ↔ 1
8(27721048-27740251)
E. coli (Escherichia coli)
Gamma proteobacteria
rimK6
ribosomal protein S6 modification protein
24(a)
1 → many
Chromosome(891190-892092)
ENSEMBL Gene Tree for RIMKLA (if available)TreeFam Gene Tree for RIMKLA (if available)
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Paralogsfor RIMKLA gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RIMKLA gene RIMKLB 2 1 SIMAP similar gene for RIMKLA using alignment to 1 protein entry: RIMKA_HUMAN :RIMKLB
RIMKLA for paralogs About GeneDecksing
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Genomic Variantsfor RIMKLA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RIMKLA (42846466 - 42889900 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RIMKLA 1 CNV : 63618
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RIMKLA
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Disorders
/ Diseasesfor RIMKLA gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor RIMKLA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RIMKLA gene integrated from 9 sources : (articles sorted by number of sources associating them with RIMKLA) Utopia : connect your pdf to the dynamic world of online information
N-acetylaspartylglutamate synthetase II synthesizes N -acetylaspartylglutamylglutamate. (PubMed id 21454531) 1 , 3 Lodder-Gadaczek J....Eckhardt M. (2011) Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase. (PubMed id 20657015) 1 , 3 Collard F....Van Schaftingen E. (2010) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RIMKLA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RIMKLA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RIMKLA gene
(According to HUGE )
About This Section --
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Specialized Databases showing RIMKLA gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RIMKLA Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RIMKLA gene: Search GeneIP for patents involving RIMKLA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RIMKLA gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs Browse OriGene 29mer shRNA kits in GFP-retroviral vector OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RIMKLA Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for RIMKLA OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RIMKLA OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RIMKLA Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RIMKLA OriGene Custom Protein Services for RIMKLA OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RIMKLA QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RIMKLA QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIMKLA QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RIMKLA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RIMKLA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RIMKLA
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RIMKLA Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMKLA
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RIMKLA
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Aliases for RIMKLA
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Expression for RIMKLA
Function for RIMKLA
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