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Aliases for RIMKLA Gene

Aliases for RIMKLA Gene

  • Ribosomal Modification Protein RimK-Like Family Member A 2 3
  • Ribosomal Protein S6 Modification-Like Protein A 3 4
  • Family With Sequence Similarity 80, Member A 2 3
  • N-Acetylaspartylglutamylglutamate Synthase A 3 4
  • N-Acetylaspartylglutamate Synthetase II 2 3
  • NAAG Synthetase A 3 4
  • FAM80A 3 4
  • NAAGS 3 4
  • N-Acetylaspartyl-Glutamate Synthetase A 3
  • N-Acetylaspartylglutamate Synthase A 3
  • RP11-157D18.1 3
  • EC 6.3.2.41 4
  • EC 6.3.2.42 4
  • NAAGS-II 3

External Ids for RIMKLA Gene

Previous Symbols for RIMKLA Gene

  • FAM80A

Summaries for RIMKLA Gene

GeneCards Summary for RIMKLA Gene

RIMKLA (Ribosomal Modification Protein RimK-Like Family Member A) is a Protein Coding gene. GO annotations related to this gene include acid-amino acid ligase activity and N-acetyl-L-aspartate-L-glutamate ligase activity. An important paralog of this gene is RIMKLB.

UniProtKB/Swiss-Prot for RIMKLA Gene

  • Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMKLA Gene

Genomics for RIMKLA Gene

Genomic Location for RIMKLA Gene

Start:
42,380,795 bp from pter
End:
42,424,229 bp from pter
Size:
43,435 bases
Orientation:
Plus strand

Genomic View for RIMKLA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIMKLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMKLA Gene

Regulatory Elements for RIMKLA Gene

Proteins for RIMKLA Gene

  • Protein details for RIMKLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXN7-RIMKA_HUMAN
    Recommended name:
    N-acetylaspartylglutamate synthase A
    Protein Accession:
    Q8IXN7
    Secondary Accessions:
    • Q5VUS5

    Protein attributes for RIMKLA Gene

    Size:
    391 amino acids
    Molecular mass:
    42864 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium or manganese ions per subunit.;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • N-acetyl-L-aspartyl-L-glutamate (NAAG) is the most abundant dipeptide present in vertebrate central nervous system (CNS).
    SequenceCaution:
    • Sequence=AAH39737.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH70661.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RIMKLA Gene

Proteomics data for RIMKLA Gene at MOPED

Post-translational modifications for RIMKLA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIMKLA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIMKLA Gene

Domains for RIMKLA Gene

UniProtKB/Swiss-Prot:

RIMKA_HUMAN
Domain:
  • Contains 1 ATP-grasp domain.:
    • Q8IXN7
Family:
  • Belongs to the RimK family.:
    • Q8IXN7
genes like me logo Genes that share domains with RIMKLA: view

No data available for Gene Families for RIMKLA Gene

Function for RIMKLA Gene

Molecular function for RIMKLA Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate
UniProtKB/Swiss-Prot CatalyticActivity: 2 ATP + N-acetyl-L-aspartate + 2 L-glutamate = 2 ADP + 2 phosphate + N-acetyl-L-aspartyl-L-glutamyl-L-glutamate
UniProtKB/Swiss-Prot Function: Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate

Enzyme Numbers (IUBMB) for RIMKLA Gene

Gene Ontology (GO) - Molecular Function for RIMKLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004363 glutathione synthase activity --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity ISS --
genes like me logo Genes that share ontologies with RIMKLA: view

Phenotypes for RIMKLA Gene

GenomeRNAi human phenotypes for RIMKLA:
genes like me logo Genes that share phenotypes with RIMKLA: view

miRNA for RIMKLA Gene

miRTarBase miRNAs that target RIMKLA

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RIMKLA Gene

Localization for RIMKLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIMKLA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIMKLA Gene COMPARTMENTS Subcellular localization image for RIMKLA gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RIMKLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RIMKLA: view

Pathways for RIMKLA Gene

SuperPathways for RIMKLA Gene

No Data Available

Interacting Proteins for RIMKLA Gene

Gene Ontology (GO) - Biological Process for RIMKLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process IEA --
GO:0006750 glutathione biosynthetic process --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with RIMKLA: view

No data available for Pathways by source for RIMKLA Gene

Compounds for RIMKLA Gene

(1) HMDB Compounds for RIMKLA Gene

Compound Synonyms Cas Number PubMed IDs
Manganese
  • manganese
7439-96-5
genes like me logo Genes that share compounds with RIMKLA: view

Transcripts for RIMKLA Gene

mRNA/cDNA for RIMKLA Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RIMKLA Gene

Ribosomal modification protein rimK-like family member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIMKLA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2:

Relevant External Links for RIMKLA Gene

GeneLoc Exon Structure for
RIMKLA
ECgene alternative splicing isoforms for
RIMKLA

Expression for RIMKLA Gene

mRNA expression in normal human tissues for RIMKLA Gene

mRNA differential expression in normal tissues according to GTEx for RIMKLA Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.7), Brain - Cortex (5.6), and Brain - Anterior cingulate cortex (BA24) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RIMKLA Gene

SOURCE GeneReport for Unigene cluster for RIMKLA Gene Hs.420244

genes like me logo Genes that share expressions with RIMKLA: view

Orthologs for RIMKLA Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIMKLA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIMKLA 36
  • 99.49 (n)
  • 100 (a)
RIMKLA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RIMKLA 36
  • 91.39 (n)
  • 96.42 (a)
RIMKLA 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIMKLA 36
  • 91.82 (n)
  • 96.93 (a)
RIMKLA 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rimkla 36
  • 87.02 (n)
  • 90.93 (a)
Rimkla 16
Rimkla 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RIMKLA 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIMKLA 37
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5186 36
zebrafish
(Danio rerio)
Actinopterygii rimkla 37
  • 65 (a)
OneToOne
Species with no ortholog for RIMKLA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIMKLA Gene

ENSEMBL:
Gene Tree for RIMKLA (if available)
TreeFam:
Gene Tree for RIMKLA (if available)

Paralogs for RIMKLA Gene

Paralogs for RIMKLA Gene

Selected SIMAP similar genes for RIMKLA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RIMKLA: view

Variants for RIMKLA Gene

Sequence variations from dbSNP and Humsavar for RIMKLA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs871645 -- 42,412,245(-) GATTT(C/G)TCTCC intron-variant
rs1055055 -- 42,414,845(+) TCTAG(C/T)GAAAG synonymous-codon, reference, utr-variant-3-prime
rs1062054 -- 42,422,265(+) TCTAA(C/T)TTCTG utr-variant-3-prime
rs1105670 -- 42,404,667(-) GGAGT(A/G)TCTTG intron-variant
rs1110071 -- 42,423,553(-) GTCAA(C/G)AGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RIMKLA Gene

Variant ID Type Subtype PubMed ID
nsv870704 CNV Gain 21882294
esv28389 CNV Loss 19812545

Relevant External Links for RIMKLA Gene

HapMap Linkage Disequilibrium report
RIMKLA

Disorders for RIMKLA Gene

No disorders were found for RIMKLA Gene.

No data available for UniProtKB/Swiss-Prot for RIMKLA Gene

Publications for RIMKLA Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase. (PMID: 20657015) Collard F. … Van Schaftingen E. (J. Biol. Chem. 2010) 2 3
  4. N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate. (PMID: 21454531) Lodder-Gadaczek J. … Eckhardt M. (J. Biol. Chem. 2011) 2 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for RIMKLA Gene

Sources for RIMKLA Gene

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