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Aliases for RIMBP3C Gene

Aliases for RIMBP3C Gene

  • RIMS Binding Protein 3C 2 3 5
  • RIM-BP3.3 3 4
  • RIM-BP3.C 3 4
  • RIMS Binding Protein 3.3 3
  • RIMS-Binding Protein 3.3 4
  • RIMS-Binding Protein 3C 3
  • RIMBP3.3 3

External Ids for RIMBP3C Gene

Previous GeneCards Identifiers for RIMBP3C Gene

  • GC22M020232
  • GC22M021900

Summaries for RIMBP3C Gene

GeneCards Summary for RIMBP3C Gene

RIMBP3C (RIMS Binding Protein 3C) is a Protein Coding gene. An important paralog of this gene is RIMBP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMBP3C Gene

Genomics for RIMBP3C Gene

Regulatory Elements for RIMBP3C Gene


Promoters for RIMBP3C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001842109 1261 2001 KLF1 ZBED1 CEBPB ZIC2 HDAC8 KAT8

Genomic Location for RIMBP3C Gene

Chromosome:
22
Start:
21,545,357 bp from pter
End:
21,551,461 bp from pter
Size:
6,105 bases
Orientation:
Minus strand

Genomic View for RIMBP3C Gene

Genes around RIMBP3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIMBP3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIMBP3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMBP3C Gene

Proteins for RIMBP3C Gene

  • Protein details for RIMBP3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJZ7-RIM3C_HUMAN
    Recommended name:
    RIMS-binding protein 3C
    Protein Accession:
    A6NJZ7

    Protein attributes for RIMBP3C Gene

    Size:
    1639 amino acids
    Molecular mass:
    180950 Da
    Quaternary structure:
    • Interacts with FASLG.

neXtProt entry for RIMBP3C Gene

Post-translational modifications for RIMBP3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIMBP3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIMBP3C Gene

Domains & Families for RIMBP3C Gene

Protein Domains for RIMBP3C Gene

Suggested Antigen Peptide Sequences for RIMBP3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NJZ7

UniProtKB/Swiss-Prot:

RIM3C_HUMAN :
  • Contains 2 fibronectin type-III domains.
  • Belongs to the RIMBP family.
Domain:
  • Contains 2 fibronectin type-III domains.
  • Contains 3 SH3 domains.
Family:
  • Belongs to the RIMBP family.
genes like me logo Genes that share domains with RIMBP3C: view

No data available for Gene Families for RIMBP3C Gene

Function for RIMBP3C Gene

Phenotypes for RIMBP3C Gene

genes like me logo Genes that share phenotypes with RIMBP3C: view

Animal Models for RIMBP3C Gene

MGI Knock Outs for RIMBP3C:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIMBP3C Gene

Localization for RIMBP3C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIMBP3C Gene COMPARTMENTS Subcellular localization image for RIMBP3C gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIMBP3C Gene

Pathways & Interactions for RIMBP3C Gene

SuperPathways for RIMBP3C Gene

No Data Available

Interacting Proteins for RIMBP3C Gene

Selected Interacting proteins: A6NJZ7-RIM3C_HUMAN for RIMBP3C Gene via IID

Gene Ontology (GO) - Biological Process for RIMBP3C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RIMBP3C Gene

Transcripts for RIMBP3C Gene

mRNA/cDNA for RIMBP3C Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(29) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RIMBP3C Gene

RIMS binding protein 3C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIMBP3C Gene

No ASD Table

Relevant External Links for RIMBP3C Gene

GeneLoc Exon Structure for
RIMBP3C
ECgene alternative splicing isoforms for
RIMBP3C

Expression for RIMBP3C Gene

mRNA expression in normal human tissues for RIMBP3C Gene

mRNA expression in normal human tissues for RIMBP3C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of RIMBP3C Gene:

RIMBP3C

SOURCE GeneReport for Unigene cluster for RIMBP3C Gene:

Hs.447643
genes like me logo Genes that share expression patterns with RIMBP3C: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RIMBP3C Gene

Orthologs for RIMBP3C Gene

This gene was present in the common ancestor of animals.

Orthologs for RIMBP3C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC486445 34
  • 79.31 (n)
cow
(Bos Taurus)
Mammalia RIMBP3B 34
  • 75.37 (n)
-- 35
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rimbp3 34
  • 73.95 (n)
mouse
(Mus musculus)
Mammalia Rimbp3 34 16 35
  • 73.66 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 17 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-105f12.2 35
  • 30 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Rbp 35
  • 13 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-168 35
  • 16 (a)
OneToMany
Species where no ortholog for RIMBP3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RIMBP3C Gene

ENSEMBL:
Gene Tree for RIMBP3C (if available)
TreeFam:
Gene Tree for RIMBP3C (if available)

Paralogs for RIMBP3C Gene

Paralogs for RIMBP3C Gene

(2) SIMAP similar genes for RIMBP3C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIMBP3C: view

Variants for RIMBP3C Gene

Sequence variations from dbSNP and Humsavar for RIMBP3C Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1610467 -- 21,546,735(+) GGGGT(C/G)AAGAG reference, synonymous-codon
rs200234327 -- 21,545,388(+) ACATA(A/G)GACAG downstream-variant-500B
rs200855787 -- 21,552,230(+) TCTGT(C/T)GCCAG intron-variant, upstream-variant-2KB
rs201052475 -- 21,546,440(+) TAGGC(A/G)CCCGG reference, missense
rs201107952 -- 21,545,248(+) TCAGC(C/G)AGGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RIMBP3C Gene

Variant ID Type Subtype PubMed ID
dgv4486n100 CNV gain 25217958
dgv4487n100 CNV gain 25217958
dgv4488n100 CNV gain 25217958
dgv4489n100 CNV gain 25217958
dgv4491n100 CNV gain 25217958
dgv7996n54 CNV gain 21841781
dgv819e199 CNV deletion 23128226
dgv820e199 CNV deletion 23128226
esv25508 CNV gain+loss 19812545
esv2661723 CNV deletion 23128226
esv2678291 CNV deletion 23128226
esv2760719 CNV gain 21179565
esv2763699 CNV gain+loss 21179565
esv28075 CNV gain+loss 19812545
esv3584494 CNV gain 24956385
esv3893444 CNV gain 25118596
nsv1066391 CNV gain 25217958
nsv1072204 CNV deletion 25765185
nsv1072625 CNV deletion 25765185
nsv1118945 CNV deletion 24896259
nsv1160729 CNV duplication 26073780
nsv1160730 CNV deletion 26073780
nsv428386 CNV loss 18775914
nsv436864 CNV insertion 17901297
nsv437849 CNV loss 16327808
nsv442791 CNV gain 18776908
nsv469545 CNV gain 16826518
nsv471490 CNV gain 19718026
nsv471596 CNV gain+loss 15918152
nsv511071 OTHER inversion 20534489
nsv7350 OTHER inversion 18451855
nsv834145 CNV loss 17160897
nsv953041 CNV deletion 24416366
nsv953042 CNV deletion 24416366
nsv962765 CNV duplication 23825009
nsv966082 CNV duplication 23825009

Variation tolerance for RIMBP3C Gene

Gene Damage Index Score: 0.00; 0.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIMBP3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIMBP3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIMBP3C Gene

Disorders for RIMBP3C Gene

Relevant External Links for RIMBP3C

Genetic Association Database (GAD)
RIMBP3C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIMBP3C

No disorders were found for RIMBP3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIMBP3C Gene

Publications for RIMBP3C Gene

  1. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M. … Janssen O. (BMC Immunol. 2009) 3 4 64
  2. Structure and evolution of RIM-BP genes: identification of a novel family member. (PMID: 17855024) Mittelstaedt T. … Schoch S. (Gene 2007) 2 3 64
  3. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han J.W. … Zhang X.J. (Nat. Genet. 2009) 46 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4 64

Products for RIMBP3C Gene

Sources for RIMBP3C Gene

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