RIMBP3C Gene
protein-coding GIFtS: 39
GCID: GC22M021900
|
|
RIMS binding protein 3C
| |
Aliases
for RIMBP3C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RIMS Binding Protein 3C1 2 | | RIMBP3.32 | | RIM-BP3.32 3 | | RIMS Binding Protein 3.32 | | RIM-BP3.C2 3 | | RIMS-Binding Protein 3C2 | | RIMS-Binding Protein 3.32 3 | | |
Export aliases for RIMBP3C gene to outside databasesPrevious GC identifer: GC22M020232 |
Summaries
for RIMBP3C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RIMBP3C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RIMBP3C gene promoter:
ER-alpha p53 Brachyury POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Egr-4 COMP1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RIMBP3C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIMBP3C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21RIMBP3C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M021900: view genomic region
(about GC identifiers)
Start:
|
21,899,646 bp from pter |
End:
|
21,905,750 bp from pter |
Size:
|
6,105 bases |
Orientation:
|
minus strand |
|
Proteins
for RIMBP3C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RIM3C_HUMAN, A6NJZ7 (See
protein sequence)Recommended Name: RIMS-binding protein 3C Size: 1639 amino acids; 180950 Da
Subunit: Interacts with FASLG
Caution: It is uncertain whether Met-1 or Met-95 is the initiatorExplore the universe of human proteins at neXtProt for RIMBP3C: NX_A6NJZ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NJZ7
RIMBP3C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001122105.1
ENSEMBL proteins: ENSP00000350885 ENSP00000390630
Human Recombinant Protein Products:
RIMBP3C Antibody Products:
Assay Products for RIMBP3C: |
Protein
Domains /
Families
for RIMBP3C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RIMBP3C for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NJZ7ProtoNet protein and cluster: A6NJZ7 UniProtKB/Swiss-Prot: RIM3C_HUMAN, A6NJZ7Similarity: Belongs to the RIMBP familySimilarity: Contains 2 fibronectin type-III domainsSimilarity: Contains 3 SH3 domains |
Function
for RIMBP3C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RIMBP3C (NM_001128633) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIMBP3C | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RIMBP3C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMBP3C |
|
Pathways & Interactions
for RIMBP3C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIMBP3C
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RIMBP3C (A6NJZ73 ENSP000003906304) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for RIMBP3C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RIMBP3C
Search CenterWatch for drugs/clinical trials and news about RIMBP3C / RIM3C
|
Transcripts
for RIMBP3C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RIMBP3C gene: NM_001128633.1 Unigene Cluster for RIMBP3C: RIMS binding protein 3C Hs.447643 [show with all ESTs]Unigene Representative Sequence: NM_0011286332 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000331505 ENST00000433039(uc002zuy.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3C
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RIMBP3C (NM_001128633) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIMBP3C | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RIMBP3C |
3 DOTS entries: DT.411088 DT.120668223 DT.91975520 24/29 AceView cDNA sequences (see all 29): BU738457 AA782009 AI240644 AI014598 AA973051 AA813520 BU540506 AI301209 AL133030 AW172455 AW086440 BM712850 BV193892 BG723046 BC035246 AL041043 BV193885 BV193890 BV197087 BV176571 AB051453 BV197086 BV193891 AW958311
GeneLoc Exon Structure
|
Expression
for RIMBP3C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RIMBP3C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTCCAAGT
About this image
See RIMBP3C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIMBP3C
SOURCE GeneReport for Unigene cluster: Hs.447643
SABiosciences Custom PCR Arrays for RIMBP3C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIMBP3C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIMBP3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIMBP3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIMBP3C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMBP3C |
Orthologs
for RIMBP3C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RIMBP3C gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
38(a) |
1 → many |
GL343312.1(18496-22269) |
zebrafish
(Danio rerio) |
Actinopterygii |
CU633486.16 |
-- |
34(a) |
possible ortholog |
15(14394704-14400568) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rbp6 |
RIM-binding protein |
12(a) |
1 → many |
3R(11200424-11228265) |
worm
(Caenorhabditis elegans) |
Secernentea |
tag-1686 |
Temporarily Assigned Gene name family member (tag-... |
15(a) |
1 → many |
III(1789138-1806612) |
ENSEMBL Gene Tree for RIMBP3C (if available)
TreeFam Gene Tree for RIMBP3C (if available) |
Paralogs
for RIMBP3C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RIMBP3C gene
- RIMBP3B1 2 RIMBP31 2 BZRAP12 RIMBP22
2 SIMAP similar genes for RIMBP3C using alignment to 2 protein entries: RIM3C_HUMAN (see all proteins):RIMBP3 RIMBP3B
RIMBP3C for paralogs About GeneDecksing
|
Genomic Variants
for RIMBP3C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RIMBP3C (21899646 - 21905750 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for RIMBP3C
13 CNVs: 73765 73772 5173 2263 73773 90900 79463 0817 79461 90898 73759 38956 79464 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIMBP3C |
|
Disorders
/ Diseases
for RIMBP3C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RIMBP3C for disorders About GeneDecksing
OMIM gene information: 612701
OMIM disorders: --
1  disease for RIMBP3C: About MalaCardsneuronitis
Export disorders for RIMBP3C gene to outside databases
|
Publications
for RIMBP3C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RIMBP3C gene integrated from 9 sources:
(articles sorted by number of sources associating them with RIMBP3C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
- Structure and evolution of RIM-BP genes: identificati on of a novel family member. (PubMed id 17855024)1, 3 Mittelstaedt T. and Schoch S. (2007)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for RIMBP3C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RIMBP3C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RIMBP3C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RIMBP3C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RIMBP3C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RIMBP3C gene:
Search GeneIP for patents involving RIMBP3C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RIMBP3C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RIMBP3C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIMBP3C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIMBP3C | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RIMBP3C | | OriGene 3'-UTR Clone for RIMBP3C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RIMBP3C | | OriGene Custom Protein Services for RIMBP3C | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RIMBP3C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIMBP3C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIMBP3C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIMBP3C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIMBP3C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIMBP3C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RIMBP3C |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RIMBP3C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMBP3C |
|  |  |  | | | | Search ThermoFisher Antibodies for RIMBP3C |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RIMBP3C |
|
|
|
|
