RIMBP3B Gene
protein-coding GIFtS: 36
GCID: GC22P021759
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RIMS binding protein 3B
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Aliases
for RIMBP3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RIMS Binding Protein 3B1 2 | | RIMBP3.22 | | RIM-BP3.22 3 | | RIMS Binding Protein 3.22 | | RIM-BP3.B2 3 | | RIMS-Binding Protein 3B2 | | RIMS-Binding Protein 3.22 3 | | |
Export aliases for RIMBP3B gene to outside databasesPrevious GC identifers: GC22P020067 GC22P021738 |
Summaries
for RIMBP3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RIMBP3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RIMBP3B gene promoter:
ER-alpha USF1 Brachyury POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 Egr-2 SRY USF-1 COMP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RIMBP3B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIMBP3B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21RIMBP3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P021759: view genomic region
(about GC identifiers)
Start:
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21,737,663 bp from pter |
End:
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21,743,767 bp from pter |
Size:
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6,105 bases |
Orientation:
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plus strand |
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Proteins
for RIMBP3B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RIM3B_HUMAN, A6NNM3 (See
protein sequence)Recommended Name: RIMS-binding protein 3B Size: 1639 amino acids; 180952 Da
Caution: It is uncertain whether Met-1 or Met-95 is the initiatorExplore the universe of human proteins at neXtProt for RIMBP3B: NX_A6NNM3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NNM3
RIMBP3B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001122107.1
ENSEMBL proteins: ENSP00000349531 ENSP00000407925
Human Recombinant Protein Products:
RIMBP3B Antibody Products:
Assay Products for RIMBP3B: |
Protein
Domains /
Families
for RIMBP3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RIMBP3B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NNM3ProtoNet protein and cluster: A6NNM3 UniProtKB/Swiss-Prot: RIM3B_HUMAN, A6NNM3Similarity: Belongs to the RIMBP familySimilarity: Contains 2 fibronectin type-III domainsSimilarity: Contains 3 SH3 domains |
Function
for RIMBP3B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3B
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMBP3B |
|
Pathways & Interactions
for RIMBP3B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIMBP3B
|
Drugs & Compounds
for RIMBP3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RIMBP3B
Search CenterWatch for drugs/clinical trials and news about RIMBP3B / RIM3B
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Transcripts
for RIMBP3B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RIMBP3B gene: NM_001128635.1 Unigene Cluster for RIMBP3B: RIMS binding protein 3B Hs.568257 [show with all ESTs]Unigene Representative Sequence: NM_0011286352 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357029 ENST00000434111(uc002zuq.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIMBP3B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RIMBP3B (NM_001128635) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RIMBP3B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RIMBP3B |
4 DOTS entries: DT.120647842 DT.91975520 DT.120629490 DT.95295994 24/37 AceView cDNA sequences (see all 37): AL039539 BE217742 AW268487 AL039540 AA969918 BX112696 BE883217 AA431178 AA311249 BC035246 BV193892 AA813520 AA406128 BV193887 AW086440 AL045442 BV176571 AB051453 BV197086 AW172455 AL041043 AA431504 BV197087 BV193890
GeneLoc Exon Structure
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Expression
for RIMBP3B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RIMBP3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RIMBP3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIMBP3B
SOURCE GeneReport for Unigene cluster: Hs.568257
SABiosciences Custom PCR Arrays for RIMBP3B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RIMBP3B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RIMBP3B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RIMBP3B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIMBP3B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMBP3B |
Orthologs
for RIMBP3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for RIMBP3B gene from 4/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
GL343312.1(18496-22269) |
zebrafish
(Danio rerio) |
Actinopterygii |
CU633486.16 |
-- |
33(a) |
possible ortholog |
15(14394704-14400568) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rbp6 |
RIM-binding protein |
12(a) |
1 → many |
3R(11200424-11228265) |
worm
(Caenorhabditis elegans) |
Secernentea |
tag-1686 |
Temporarily Assigned Gene name family member (tag-... |
15(a) |
1 → many |
III(1789138-1806612) |
ENSEMBL Gene Tree for RIMBP3B (if available)
TreeFam Gene Tree for RIMBP3B (if available) |
Paralogs
for RIMBP3B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RIMBP3B gene
- RIMBP3C1 2 RIMBP31 2 BZRAP12 RIMBP22
2 SIMAP similar genes for RIMBP3B using alignment to 2 protein entries: RIM3B_HUMAN (see all proteins):RIMBP3 RIMBP3C
RIMBP3B for paralogs About GeneDecksing
|
Genomic Variants
for RIMBP3B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RIMBP3B (21737663 - 21743767 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for RIMBP3B
13 CNVs: 73765 73772 5173 2263 73773 90900 79463 0817 79461 90898 73759 38956 79464 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIMBP3B |
|
Disorders
/ Diseases
for RIMBP3B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RIMBP3B for disorders About GeneDecksing
OMIM gene information: 612700
OMIM disorders: --
1  disease for RIMBP3B: About MalaCardsneuronitis
Export disorders for RIMBP3B gene to outside databases
|
Publications
for RIMBP3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RIMBP3B gene integrated from 9 sources:
(articles sorted by number of sources associating them with RIMBP3B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure and evolution of RIM-BP genes: identificati on of a novel family member. (PubMed id 17855024)1, 3 Mittelstaedt T. and Schoch S. (2007)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
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External Searches for RIMBP3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RIMBP3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RIMBP3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RIMBP3B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RIMBP3B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RIMBP3B gene:
Search GeneIP for patents involving RIMBP3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RIMBP3B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIMBP3B |
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