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Aliases for RIMBP3 Gene

Aliases for RIMBP3 Gene

  • RIMS Binding Protein 3 2 3 5
  • RIM-BP3.1 3 4
  • RIM-BP3.A 3 4
  • RIMBP3A 3 4
  • RIMS Binding Protein 3.1 3
  • RIMS-Binding Protein 3.1 4
  • RIMS-Binding Protein 3A 3
  • RIMBP3.1 3
  • KIAA1666 4
  • RIM-BP3 3

External Ids for RIMBP3 Gene

Previous GeneCards Identifiers for RIMBP3 Gene

  • GC22M018843
  • GC22M020456
  • GC22M003946

Summaries for RIMBP3 Gene

GeneCards Summary for RIMBP3 Gene

RIMBP3 (RIMS Binding Protein 3) is a Protein Coding gene. An important paralog of this gene is RIMBP3C.

Additional gene information for RIMBP3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIMBP3 Gene

Genomics for RIMBP3 Gene

Regulatory Elements for RIMBP3 Gene


Promoters for RIMBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000301096 819 1001
ENSR00000143670 1819 201 ZBTB26

Genomic Locations for RIMBP3 Gene

Genomic Locations for RIMBP3 Gene
chr22:18,605,815-18,611,919
(GRCh38/hg38)
Size:
6,105 bases
Orientation:
Minus strand
chr22:20,455,991-20,461,786
(GRCh37/hg19)

Genomic View for RIMBP3 Gene

Genes around RIMBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIMBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIMBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIMBP3 Gene

Proteins for RIMBP3 Gene

  • Protein details for RIMBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UFD9-RIM3A_HUMAN
    Recommended name:
    RIMS-binding protein 3A
    Protein Accession:
    Q9UFD9
    Secondary Accessions:
    • Q8IYP7
    • Q9BY94
    • Q9UFQ5

    Protein attributes for RIMBP3 Gene

    Size:
    1639 amino acids
    Molecular mass:
    180717 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35246.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB33336.1; Type=Frameshift; Positions=652; Evidence={ECO:0000305}; Sequence=CAB61362.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIMBP3 Gene

neXtProt entry for RIMBP3 Gene

Post-translational modifications for RIMBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIMBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIMBP3 Gene

Domains & Families for RIMBP3 Gene

Gene Families for RIMBP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RIMBP3 Gene

Suggested Antigen Peptide Sequences for RIMBP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UFD9

UniProtKB/Swiss-Prot:

RIM3A_HUMAN :
  • Belongs to the RIMBP family.
Family:
  • Belongs to the RIMBP family.
genes like me logo Genes that share domains with RIMBP3: view

Function for RIMBP3 Gene

Gene Ontology (GO) - Molecular Function for RIMBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RIMBP3: view

Phenotypes for RIMBP3 Gene

genes like me logo Genes that share phenotypes with RIMBP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RIMBP3 Gene

Localization for RIMBP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIMBP3 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (1)
  • Vesicles (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIMBP3 Gene

Pathways & Interactions for RIMBP3 Gene

SuperPathways for RIMBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIMBP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RIMBP3 Gene

Drugs & Compounds for RIMBP3 Gene

No Compound Related Data Available

Transcripts for RIMBP3 Gene

mRNA/cDNA for RIMBP3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(37) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RIMBP3 Gene

RIMS binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIMBP3 Gene

No ASD Table

Relevant External Links for RIMBP3 Gene

GeneLoc Exon Structure for
RIMBP3
ECgene alternative splicing isoforms for
RIMBP3

Expression for RIMBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIMBP3 Gene

mRNA differential expression in normal tissues according to GTEx for RIMBP3 Gene

This gene is overexpressed in Testis (x41.5).

Protein differential expression in normal tissues from HIPED for RIMBP3 Gene

This gene is overexpressed in Testis (43.1), Monocytes (13.1), and Pancreatic juice (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RIMBP3 Gene



Protein tissue co-expression partners for RIMBP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIMBP3 Gene:

RIMBP3

SOURCE GeneReport for Unigene cluster for RIMBP3 Gene:

Hs.115429
genes like me logo Genes that share expression patterns with RIMBP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIMBP3 Gene

Orthologs for RIMBP3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RIMBP3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC486445 33
  • 79.39 (n)
cow
(Bos Taurus)
Mammalia RIMBP3B 33
  • 75.55 (n)
rat
(Rattus norvegicus)
Mammalia Rimbp3 33
  • 73.95 (n)
mouse
(Mus musculus)
Mammalia Rimbp3 33
  • 73.68 (n)
Species where no ortholog for RIMBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RIMBP3 Gene

ENSEMBL:
Gene Tree for RIMBP3 (if available)
TreeFam:
Gene Tree for RIMBP3 (if available)

Paralogs for RIMBP3 Gene

Paralogs for RIMBP3 Gene

(2) SIMAP similar genes for RIMBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RIMBP3: view

Variants for RIMBP3 Gene

Sequence variations from dbSNP and Humsavar for RIMBP3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1001858495 -- 18,606,912(+) TATTG(C/G)CCACT reference, missense
rs1003534567 -- 18,612,228(+) TCTGG(A/G)CTACT upstream-variant-2KB
rs1003588524 -- 18,610,018(+) CTCCG(A/T)CAGGT reference, missense
rs1006809781 -- 18,609,196(+) GGAGG(C/T)TTCCC reference, missense
rs1007168093 -- 18,609,820(+) CTGCA(A/G)GCGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RIMBP3 Gene

Variant ID Type Subtype PubMed ID
nsv964588 CNV duplication 23825009
nsv962755 CNV duplication 23825009
nsv953028 CNV deletion 24416366
nsv820540 CNV duplication 20802225
nsv588139 CNV loss 21841781
nsv516997 CNV gain+loss 19592680
nsv471594 CNV gain+loss 15918152
nsv471339 CNV gain 19718026
nsv469578 CNV gain 16826518
nsv428385 CNV gain+loss 18775914
nsv1146969 CNV duplication 26484159
nsv1144016 CNV deletion 24896259
nsv1071779 CNV deletion 25765185
nsv1061694 CNV gain 25217958
nsv1055756 CNV gain 25217958
esv3575418 CNV gain 25503493
esv3381183 CNV duplication 20981092
esv32687 CNV gain+loss 17666407
esv2758824 CNV gain+loss 17122850
esv2751935 CNV loss 17911159
esv26930 CNV gain+loss 19812545
esv22247 CNV gain+loss 19812545
dgv99e203 CNV gain+loss 21179565
dgv817e199 CNV deletion 23128226
dgv7989n54 CNV gain 21841781
dgv7965n54 CNV gain 21841781
dgv7964n54 CNV loss 21841781
dgv7963n54 CNV gain 21841781
dgv4467n100 CNV gain 25217958
dgv4466n100 CNV gain+loss 25217958
dgv2431n106 OTHER inversion 24896259
dgv173e55 CNV gain 17911159
dgv16n31 CNV gain 19718026
dgv1283e212 CNV gain 25503493

Variation tolerance for RIMBP3 Gene

Gene Damage Index Score: 7.84; 83.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIMBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIMBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIMBP3 Gene

Disorders for RIMBP3 Gene

Relevant External Links for RIMBP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIMBP3

No disorders were found for RIMBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIMBP3 Gene

Publications for RIMBP3 Gene

  1. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 60
  2. Structure and evolution of RIM-BP genes: identification of a novel family member. (PMID: 17855024) Mittelstaedt T … Schoch S (Gene 2007) 2 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 60
  5. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60

Products for RIMBP3 Gene

Sources for RIMBP3 Gene

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