RILPL2 Gene
protein-coding GIFtS: 45
GCID: GC12M123899
|
|
Rab interacting lysosomal protein-like 2
| |
Aliases
for RILPL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rab Interacting Lysosomal Protein-Like 21 2 | | FLJ303801 | | Rab-Interacting Lysosomal Protein-Like 22 3 | | FLJ323721 | | RLP22 3 | | MGC70361 | | P40phox-Binding Protein2 3 | | RILP-Like Protein 22 |
Export aliases for RILPL2 gene to outside databasesPrevious GC identifers: GC12M122466 GC12M120861 |
Summaries
for RILPL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RIPL2_HUMAN, Q969X0Function: Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance ofdendritic spines. May activate RAC1 (By similarity)
|
Genomic Views
for RILPL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RILPL2 gene promoter:
XBP-1 YY1 Meis-1b POU2F1a POU2F1b c-Myb Meis-1a POU2F1c Meis-1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RILPL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RILPL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31RILPL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M123899: view genomic region
(about GC identifiers)
Start:
|
123,899,936 bp from pter |
End:
|
123,921,264 bp from pter |
Size:
|
21,329 bases |
Orientation:
|
minus strand |
|
Proteins
for RILPL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RIPL2_HUMAN, Q969X0 (See
protein sequence)Recommended Name: RILP-like protein 2 Size: 211 amino acids; 23986 Da
Subunit: Interacts (via N-terminus) with MYO5A, the interaction is required for its role in dendrite formation.Interacts with RAC1 (By similarity)
Subcellular location: Cytoplasm, cytosolExplore the universe of human proteins at neXtProt for RILPL2: NX_Q969X0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969X0
RILPL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_659495.1
ENSEMBL proteins: ENSP00000280571
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RILPL2 for ontologies About GeneDecksing
RILPL2 Antibody Products:
Assay Products for RILPL2: |
Protein
Domains /
Families
for RILPL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RILPL2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969X0ProtoNet protein and cluster: Q969X0 UniProtKB/Swiss-Prot: RIPL2_HUMAN, Q969X0Similarity: Belongs to the RILPL familySimilarity: Contains 1 RILP-like domain |
Function
for RILPL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RIPL2_HUMAN, Q969X0Function: Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance ofdendritic spines. May activate RAC1 (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RILPL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RILPL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RILPL2 (NM_145058) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RILPL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RILPL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RILPL2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RILPL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RILPL2:
|
Pathways & Interactions
for RILPL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RILPL2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/8 Interacting proteins for RILPL2 (Q969X01, 2, 3 ENSP000002805714) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for RILPL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RILPL2
Search CenterWatch for drugs/clinical trials and news about RILPL2 / RIPL2
|
Transcripts
for RILPL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RILPL2 gene: NM_145058.1 Unigene Cluster for RILPL2: Rab interacting lysosomal protein-like 2 Hs.488173 [show with all ESTs]Unigene Representative Sequence: AK0549421 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000280571(uc001uey.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RILPL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RILPL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RILPL2 (NM_145058) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RILPL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RILPL2 |
Additional cDNA sequence: AB085763.1 AK054942.1 AK056934.1 BC013042.2 3 DOTS entries: DT.205620 DT.97861820 DT.121194007 24/91 AceView cDNA sequences (see all 91): NM_145058 CA867308 AK056934 BM974945 BC013042 CB268532 CB154186 AI288327 BM129125 BX280912 BM810460 CK819475 CA777862 AI126012 AI613168 BM556155 CA867592 AI206046 BM715001 BQ221668 AB085763 BQ711724 AI446323 AK054942
GeneLoc Exon Structure
|
Expression
for RILPL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RILPL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTCTTTA
About this image
See RILPL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RILPL2
SOURCE GeneReport for Unigene cluster: Hs.488173
UniProtKB/Swiss-Prot: RIPL2_HUMAN, Q969X0Tissue specificity: Widely expressed. Expressed at higher level in lung
SABiosciences Custom PCR Arrays for RILPL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RILPL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RILPL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RILPL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RILPL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RILPL2 |
Orthologs
for RILPL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RILPL2 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RILPL21 |
Rab interacting lysosomal protein-like 2 |
69.9(n)
65.31(a) |
|
416824 XM_415115.3 XP_415115.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RILPL26 |
-- |
60(a) |
1 ↔ 1 |
LGb(1802113-1804687) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.193982 |
Xenopus laevis transcribed sequence with weak similarity more |
76.01(n) |
|
AW644941.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rilpl21 |
Rab interacting lysosomal protein-like 2 |
60.74(n)
53.89(a) |
|
100004718 NM_001083850.1 NP_001077319.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG114486 |
-- |
8(a) |
1 → many |
X(1287087-1291370) |
worm
(Caenorhabditis elegans) |
Secernentea |
rilp-16 |
-- |
9(a) |
1 → many |
III(3636028-3643654) |
ENSEMBL Gene Tree for RILPL2 (if available)
TreeFam Gene Tree for RILPL2 (if available) |
Paralogs
for RILPL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RILPL2 gene
- RILP2 RILPL12
RILPL2 for paralogs About GeneDecksing
|
Genomic Variants
for RILPL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RILPL2 (123899936 - 123921264 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RILPL2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RILPL2 |
|
Disorders
/ Diseases
for RILPL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RILPL2 for disorders About GeneDecksing
OMIM gene information: 614093
OMIM disorders: --
1  disease for RILPL2: About MalaCardsneuronitis
Export disorders for RILPL2 gene to outside databases
|
Publications
for RILPL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RILPL2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RILPL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PubMed id 14668488)1, 2, 3 Wang T.... Hong W. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for RILPL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RILPL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RILPL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RILPL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RILPL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RILPL2 gene:
Search GeneIP for patents involving RILPL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RILPL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RILPL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RILPL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RILPL2 | | | OriGene Protein Over-expression Lysate for RILPL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RILPL2 | | OriGene 3'-UTR Clone for RILPL2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RILPL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RILPL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RILPL2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RILPL2 | | OriGene Custom Protein Services for RILPL2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RILPL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RILPL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RILPL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RILPL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RILPL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RILPL2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RILPL2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RILPL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RILPL2 |
|  |  |  | | | | ThermoFisher Antibody for RILPL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RILPL2 |
|
|
|
|
