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Aliases for RILPL2 Gene

Aliases for RILPL2 Gene

  • Rab Interacting Lysosomal Protein-Like 2 2 3
  • RLP2 3 4 6
  • Rab-Interacting Lysosomal Protein-Like 2 3 4
  • P40phox-Binding Protein 3 4
  • RILP-Like Protein 2 3

External Ids for RILPL2 Gene

Summaries for RILPL2 Gene

Entrez Gene Summary for RILPL2 Gene

  • This gene encodes a protein that contains a rab-interacting lysosomal protein-like domain. This protein may be involved in regulating lysosome morphology. This protein may also be a target for the Hepatitis C virus and assist in viral replication. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for RILPL2 Gene

RILPL2 (Rab Interacting Lysosomal Protein-Like 2) is a Protein Coding gene. GO annotations related to this gene include identical protein binding. An important paralog of this gene is RILP.

UniProtKB/Swiss-Prot for RILPL2 Gene

  • Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RILPL2 Gene

Genomics for RILPL2 Gene

Genomic Location for RILPL2 Gene

Start:
123,410,683 bp from pter
End:
123,436,717 bp from pter
Size:
26,035 bases
Orientation:
Minus strand

Genomic View for RILPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RILPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RILPL2 Gene

Regulatory Elements for RILPL2 Gene

Proteins for RILPL2 Gene

  • Protein details for RILPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969X0-RIPL2_HUMAN
    Recommended name:
    RILP-like protein 2
    Protein Accession:
    Q969X0
    Secondary Accessions:

    Protein attributes for RILPL2 Gene

    Size:
    211 amino acids
    Molecular mass:
    23986 Da
    Quaternary structure:
    • Interacts with RAC1. Homodimer. Interacts (via N-terminus) with MYO5A, the interaction is required for its role in dendrite formation (By similarity).

neXtProt entry for RILPL2 Gene

Proteomics data for RILPL2 Gene at MOPED

Post-translational modifications for RILPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RILPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RILPL2 Gene

Domains for RILPL2 Gene

Protein Domains for RILPL2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RIPL2_HUMAN
Domain:
  • Contains 1 RILP-like domain.:
    • Q969X0
Family:
  • Belongs to the RILPL family.:
    • Q969X0
genes like me logo Genes that share domains with RILPL2: view

No data available for Gene Families for RILPL2 Gene

Function for RILPL2 Gene

Molecular function for RILPL2 Gene

UniProtKB/Swiss-Prot Function: Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity).

Gene Ontology (GO) - Molecular Function for RILPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with RILPL2: view

Phenotypes for RILPL2 Gene

GenomeRNAi human phenotypes for RILPL2:
genes like me logo Genes that share phenotypes with RILPL2: view

miRNA for RILPL2 Gene

miRTarBase miRNAs that target RILPL2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RILPL2 Gene

Localization for RILPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RILPL2 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RILPL2 Gene COMPARTMENTS Subcellular localization image for RILPL2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RILPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome ISS --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 23376485
GO:0072372 primary cilium ISS --
genes like me logo Genes that share ontologies with RILPL2: view

Pathways for RILPL2 Gene

SuperPathways for RILPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RILPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis ISS --
GO:0006886 intracellular protein transport ISS --
genes like me logo Genes that share ontologies with RILPL2: view

No data available for Pathways by source for RILPL2 Gene

Transcripts for RILPL2 Gene

mRNA/cDNA for RILPL2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(91) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RILPL2 Gene

Rab interacting lysosomal protein-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RILPL2 Gene

No ASD Table

Relevant External Links for RILPL2 Gene

GeneLoc Exon Structure for
RILPL2
ECgene alternative splicing isoforms for
RILPL2

Expression for RILPL2 Gene

mRNA expression in normal human tissues for RILPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RILPL2 Gene

This gene is overexpressed in Whole Blood (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RILPL2 Gene

SOURCE GeneReport for Unigene cluster for RILPL2 Gene Hs.488173

mRNA Expression by UniProt/SwissProt for RILPL2 Gene

Q969X0-RIPL2_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in lung.
genes like me logo Genes that share expressions with RILPL2: view

Orthologs for RILPL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RILPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RILPL2 36
  • 99.53 (n)
  • 99.05 (a)
RILPL2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RILPL2 36
  • 87.57 (n)
  • 84.86 (a)
RILPL2 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RILPL2 36
  • 87.36 (n)
  • 83.52 (a)
RILPL2 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rilpl2 36
  • 81.32 (n)
  • 78.57 (a)
Rilpl2 16
Rilpl2 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
OneToMany
-- 37
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RILPL2 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rilpl2 36
  • 82.78 (n)
  • 81.87 (a)
chicken
(Gallus gallus)
Aves RILPL2 36
  • 67.05 (n)
  • 65.91 (a)
RILPL2 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RILPL2 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19398 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rilpl2 36
  • 64.1 (n)
  • 60.44 (a)
zebrafish
(Danio rerio)
Actinopterygii rilpl2 36
  • 61.46 (n)
  • 54.91 (a)
rilpl2 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11448 37
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rilp-1 37
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2252 37
  • 14 (a)
OneToMany
Species with no ortholog for RILPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RILPL2 Gene

ENSEMBL:
Gene Tree for RILPL2 (if available)
TreeFam:
Gene Tree for RILPL2 (if available)

Paralogs for RILPL2 Gene

Paralogs for RILPL2 Gene

genes like me logo Genes that share paralogs with RILPL2: view

Variants for RILPL2 Gene

Sequence variations from dbSNP and Humsavar for RILPL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1660 -- 123,415,560(+) CGTGG(A/G)AGCAG utr-variant-3-prime, nc-transcript-variant
rs1662 -- 123,415,589(+) TGCAC(A/G)CTGGA nc-transcript-variant
rs951328 -- 123,432,442(+) CTGAA(A/G)CTGCA intron-variant
rs1355721 -- 123,415,636(+) CCCCC(A/C)CCCTG utr-variant-3-prime, nc-transcript-variant
rs1706475 -- 123,435,140(+) ACGCC(A/G)CTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RILPL2 Gene

Variant ID Type Subtype PubMed ID
nsv899579 CNV Loss 21882294

Relevant External Links for RILPL2 Gene

HapMap Linkage Disequilibrium report
RILPL2

Disorders for RILPL2 Gene

No disorders were found for RILPL2 Gene.

No data available for UniProtKB/Swiss-Prot for RILPL2 Gene

Publications for RILPL2 Gene

  1. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PMID: 14668488) Wang T. … Hong W. (Mol. Biol. Cell 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for RILPL2 Gene

Sources for RILPL2 Gene

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