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Aliases for RILPL2 Gene

Aliases for RILPL2 Gene

  • Rab Interacting Lysosomal Protein Like 2 2 3 5
  • Rab-Interacting Lysosomal Protein-Like 2 3 4
  • P40phox-Binding Protein 3 4
  • RLP2 3 4
  • Rab Interacting Lysosomal Protein-Like 2 2
  • RILP-Like Protein 2 3

External Ids for RILPL2 Gene

Previous GeneCards Identifiers for RILPL2 Gene

  • GC12M122466
  • GC12M123899
  • GC12M120861

Summaries for RILPL2 Gene

Entrez Gene Summary for RILPL2 Gene

  • This gene encodes a protein that contains a rab-interacting lysosomal protein-like domain. This protein may be involved in regulating lysosome morphology. This protein may also be a target for the Hepatitis C virus and assist in viral replication. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for RILPL2 Gene

RILPL2 (Rab Interacting Lysosomal Protein Like 2) is a Protein Coding gene. Diseases associated with RILPL2 include Hepatitis C Virus. GO annotations related to this gene include identical protein binding. An important paralog of this gene is RILPL1.

UniProtKB/Swiss-Prot for RILPL2 Gene

  • Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RILPL2 Gene

Genomics for RILPL2 Gene

Regulatory Elements for RILPL2 Gene

Enhancers for RILPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G123431 1.7 FANTOM5 ENCODE dbSUPER 44.6 +2.4 2365 6.0 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 RILPL2 CDK2AP1 ABCB9 ENSG00000256092 SBNO1 C12orf65 KMT5A
GH12G123447 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.8 -12.3 -12268 2.4 ELF3 FOXA2 DMAP1 ZBTB40 THRB RARA ZNF121 RCOR1 CREM MIXL1 RILPL2 LOC101927415 CDK2AP1 DNAH10 SNRNP35 C12orf65 ENSG00000270445
GH12G123457 1.4 ENCODE dbSUPER 12.3 -22.2 -22198 2.8 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 RILPL2 RILPL1 LOC101927415 SNRNP35 PIR40920 ENSG00000274427
GH12G123470 1.2 ENCODE dbSUPER 12.5 -35.1 -35074 1.6 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 FOS SP5 ZHX2 MXD4 DDX55 RILPL2 LOC101927415 TMED2 RILPL1 EIF2B1 GTF2H3 PITPNM2 SNRNP35 PIR40920
GH12G123464 0.7 dbSUPER 12.6 -28.7 -28678 1.3 GATAD2A SAP130 DMAP1 RAD21 YY1 JUND ZGPAT HNF4G NR2F6 HNF4A LOC101927415 RILPL2 TMED2 RILPL1 DDX55 PITPNM2 SNRNP35 PIR40920 ENSG00000274427
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RILPL2 on UCSC Golden Path with GeneCards custom track

Promoters for RILPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058743 233 1801 HDGF CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for RILPL2 Gene

Chromosome:
12
Start:
123,410,076 bp from pter
End:
123,436,733 bp from pter
Size:
26,658 bases
Orientation:
Minus strand

Genomic View for RILPL2 Gene

Genes around RILPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RILPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RILPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RILPL2 Gene

Proteins for RILPL2 Gene

  • Protein details for RILPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969X0-RIPL2_HUMAN
    Recommended name:
    RILP-like protein 2
    Protein Accession:
    Q969X0

    Protein attributes for RILPL2 Gene

    Size:
    211 amino acids
    Molecular mass:
    23986 Da
    Quaternary structure:
    • Interacts with RAC1. Homodimer. Interacts (via N-terminus) with MYO5A, the interaction is required for its role in dendrite formation (By similarity).

neXtProt entry for RILPL2 Gene

Post-translational modifications for RILPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RILPL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RILPL2 Gene

Domains & Families for RILPL2 Gene

Protein Domains for RILPL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RILPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969X0

UniProtKB/Swiss-Prot:

RIPL2_HUMAN :
  • Belongs to the RILPL family.
Family:
  • Belongs to the RILPL family.
genes like me logo Genes that share domains with RILPL2: view

No data available for Gene Families for RILPL2 Gene

Function for RILPL2 Gene

Molecular function for RILPL2 Gene

UniProtKB/Swiss-Prot Function:
Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity).

Gene Ontology (GO) - Molecular Function for RILPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031267 small GTPase binding IBA --
GO:0042802 identical protein binding IPI 16189514
GO:0046983 protein dimerization activity IEA --
GO:0051959 dynein light intermediate chain binding IBA --
genes like me logo Genes that share ontologies with RILPL2: view
genes like me logo Genes that share phenotypes with RILPL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RILPL2

CRISPR Products

miRNA for RILPL2 Gene

miRTarBase miRNAs that target RILPL2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RILPL2 Gene

Localization for RILPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RILPL2 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RILPL2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for RILPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA,IEA --
GO:0005813 centrosome ISS,IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with RILPL2: view

Pathways & Interactions for RILPL2 Gene

SuperPathways for RILPL2 Gene

No Data Available

Interacting Proteins for RILPL2 Gene

Gene Ontology (GO) - Biological Process for RILPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis ISS --
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0060271 cilium assembly IBA --
GO:1903445 protein transport from ciliary membrane to plasma membrane ISS,IEA --
genes like me logo Genes that share ontologies with RILPL2: view

No data available for Pathways by source and SIGNOR curated interactions for RILPL2 Gene

Drugs & Compounds for RILPL2 Gene

No Compound Related Data Available

Transcripts for RILPL2 Gene

mRNA/cDNA for RILPL2 Gene

Unigene Clusters for RILPL2 Gene

Rab interacting lysosomal protein-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RILPL2 Gene

No ASD Table

Relevant External Links for RILPL2 Gene

GeneLoc Exon Structure for
RILPL2
ECgene alternative splicing isoforms for
RILPL2

Expression for RILPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RILPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RILPL2 Gene

This gene is overexpressed in Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for RILPL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.7), Monocytes (18.5), Platelet (9.5), and Pancreas (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RILPL2 Gene



Protein tissue co-expression partners for RILPL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RILPL2 Gene:

RILPL2

SOURCE GeneReport for Unigene cluster for RILPL2 Gene:

Hs.488173

mRNA Expression by UniProt/SwissProt for RILPL2 Gene:

Q969X0-RIPL2_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in lung.

Evidence on tissue expression from TISSUES for RILPL2 Gene

  • Kidney(4.3)
genes like me logo Genes that share expression patterns with RILPL2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RILPL2 Gene

Orthologs for RILPL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RILPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RILPL2 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia RILPL2 34 35
  • 87.57 (n)
dog
(Canis familiaris)
Mammalia RILPL2 34 35
  • 87.36 (n)
rat
(Rattus norvegicus)
Mammalia Rilpl2 34
  • 82.78 (n)
mouse
(Mus musculus)
Mammalia Rilpl2 34 16 35
  • 81.32 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RILPL2 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves RILPL2 34 35
  • 67.05 (n)
lizard
(Anolis carolinensis)
Reptilia RILPL2 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rilpl2 34
  • 64.1 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19398 34
zebrafish
(Danio rerio)
Actinopterygii rilpl2 34 35
  • 61.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11448 35
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rilp-1 35
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2252 35
  • 14 (a)
OneToMany
Species where no ortholog for RILPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RILPL2 Gene

ENSEMBL:
Gene Tree for RILPL2 (if available)
TreeFam:
Gene Tree for RILPL2 (if available)

Paralogs for RILPL2 Gene

Paralogs for RILPL2 Gene

genes like me logo Genes that share paralogs with RILPL2: view

Variants for RILPL2 Gene

Sequence variations from dbSNP and Humsavar for RILPL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000040163 -- 123,413,593(+) AAGCA(A/G)TAGTA intron-variant
rs1000058549 -- 123,435,052(+) GCACA(C/T)GCTTG intron-variant
rs1000114010 -- 123,419,160(+) CGCCC(A/G)CTACC intron-variant
rs1000122889 -- 123,425,863(+) GCCAG(A/G)CTGGT intron-variant
rs1000186067 -- 123,420,625(+) AGAGA(C/T)GGGGC intron-variant

Variation tolerance for RILPL2 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RILPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RILPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RILPL2 Gene

Disorders for RILPL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RILPL2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RILPL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RILPL2
genes like me logo Genes that share disorders with RILPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RILPL2 Gene

Publications for RILPL2 Gene

  1. A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. (PMID: 14668488) Wang T. … Hong W. (Mol. Biol. Cell 2004) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
  4. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3 64

Products for RILPL2 Gene

Sources for RILPL2 Gene

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