Aliases for RILP Gene
External Ids for RILP Gene
Previous GeneCards Identifiers for RILP Gene
This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]
GeneCards Summary for RILP Gene
RILP (Rab Interacting Lysosomal Protein) is a Protein Coding gene. Among its related pathways are Immune System and Salmonella infection (KEGG). GO annotations related to this gene include Rab GTPase binding. An important paralog of this gene is RILPL1.
UniProtKB/Swiss-Prot for RILP Gene
Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.