Aliases for RIF1 Gene
External Ids for RIF1 Gene
Previous GeneCards Identifiers for RIF1 Gene
This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
GeneCards Summary for RIF1 Gene
RIF1 (Replication Timing Regulatory Factor 1) is a Protein Coding gene. Diseases associated with RIF1 include Candida Glabrata. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and DNA Double Strand Break Response. GO annotations related to this gene include binding.
UniProtKB/Swiss-Prot for RIF1 Gene
Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.