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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RIF1 Gene

protein-coding GIFtS: 49
GCID: GC02P152266

RAP1 interacting factor homolog (yeast)

Explore 4 diseases affiliated with
RIF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAP1 Interacting Factor Homolog (Yeast)¹ ²
Rap1-Interacting Factor 1 Homolog² ³
FLJ10599¹
FLJ12870¹
Telomere-Associated Protein RIF1²

External Ids:	HGNC: 23207¹	Entrez Gene: 55183²	Ensembl: ENSG00000080345⁷	OMIM: 608952⁵	UniProtKB: Q5UIP0³

Export aliases for RIF1 gene to outside databases

Previous GC identifers: GC01M110591 GC01M110788 GC01M111201 GC02P152093 GC02P151974 GC02P144162

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIF1:

This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1.

This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple

transcript variants. (provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: RIF1_HUMAN, Q5UIP0

Function: Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase

(the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase:

one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of

both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints

Gene Wiki entry for RIF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RIF1 gene promoter:
TBP p53 ATF-2 CUTL1 YY1 CREB CRE-BP1 deltaCREB HFH-1 TFIID
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RIF1 promoter sequence

Search SABiosciences Chromatin IP Primers for RIF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3 Ensembl cytogenetic band: 2q23.3 HGNC cytogenetic band: 2q23.3

RIF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIF1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P152266: view genomic region (about GC identifiers)

Start:	152,266,397 bp from pter	End:	152,364,527 bp from pter
Size:	98,131 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RIF1_HUMAN, Q5UIP0 (See protein sequence)

Recommended Name: Telomere-associated protein RIF1

Size: 2472 amino acids; 274466 Da

Subcellular location: Nucleus. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Note=Exhibits ATM- and

TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not

associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during

anaphase, and to condensed chromosomes in telophase

Developmental stage: Expression peaks in late G2/S phase of the cell cycle

Sequence caution: Sequence=BAA91705.1; Type=Erroneous initiation; Sequence=BAB14313.1; Type=Erroneous initiation;

Sequence=BAB14792.1; Type=Erroneous initiation; Sequence=BAB85058.1; Type=Erroneous initiation; Sequence=CAI45961.1;

Type=Frameshift; Positions=470;

Secondary accessions: A6NC27 C9JBR1 Q5H9R3 Q5UIP2 Q66YK6 Q6PRU2 Q8TE94 Q99772 Q9H830 Q9H9B9 Q9NVP5

Q9Y4R4

Alternative splicing: 2 isoforms: Q5UIP0-1 Q5UIP0-2

Explore the universe of human proteins at neXtProt for RIF1: NX_Q5UIP0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5UIP0

RIF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001171134.1 NP_001171135.1 NP_001171136.1 NP_060621.3

ENSEMBL proteins:

ENSP00000390181 ENSP00000414615 ENSP00000415691 ENSP00000400034 ENSP00000243326

ENSP00000390486 ENSP00000416123 ENSP00000404882 ENSP00000396865

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	Uscn Proteins for RIF1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000781	chromosome, telomeric region	IEA	--
GO:0001939	female pronucleus	IEA	--
GO:0001940	male pronucleus	IEA	--
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IEA	--

RIF1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RIF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RIF1 for domains About GeneDecksing

3 InterPro domains/families:

IPR011989 ARM-like

IPR022031 Rif1_N

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q5UIP0

ProtoNet protein and cluster: Q5UIP0

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RIF1_HUMAN, Q5UIP0

Function: Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase

(the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase:

one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of

both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints

miRNA Products:		OriGene 3'-UTR Clone: RIF1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIF1
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RIF1 (see all 28):
		hsa-miR-4307 hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-503 hsa-miR-340 hsa-miR-218 hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: RIF1 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIF1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

RIF1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Rif1^tm2Sbcb for RIF1
     5 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Rif1):

cellular

growth/size

mortality/aging

normal

reproductive system

RIF1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcriptional Regulatory Network in Embryonic Stem Cell

Transcriptional Regulatory Network in Embryonic Stem Cell

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RIF1

Transcriptional Regulatory Network in Embryonic Stem Cell

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RIF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/877 Interacting proteins for RIF1 (Q5UIP0^{2, 3} ENSP00000243326⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 877)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BLM	P54132²^,³, ENSP00000347232⁴	MINT-8049128 MINT-8048995 MINT-8048961 MINT-8049038 MINT-8048980 MINT-7945693 MINT-8049010 MINT-8049107 I2D: score=1 STRING: ENSP00000347232
SMN1	Q16637²^,³	MINT-7947479 MINT-7945693 I2D: score=1
SMN2	Q16637²^,³	MINT-7947479 MINT-7945693 I2D: score=1
NACC1	Q96RE7²^,³	MINT-7947479 MINT-7945693 I2D: score=2
RANBP2	P49792²^,³	MINT-7947479 MINT-7945693 I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0007049	cell cycle	IEA	--
GO:0019827	stem cell maintenance	IEA	--

RIF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RIF1
Search CenterWatch for drugs/clinical trials and news about RIF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RIF1 gene (4 alternative transcripts):

NM_001177663.1 NM_001177664.1 NM_001177665.1 NM_018151.4

Unigene Clusters for RIF1:

RAP1 interacting factor homolog (yeast)

Hs.655671 [show with all ESTs], Hs.735592 [show with all ESTs]

Unigene Representative Sequences: NM_001177665, AL137363

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000444746(uc010fnv.2 uc002txp.3) ENST00000453091 ENST00000428287(uc010zby.1)

ENST00000494333 ENST00000420714 ENST00000243326(uc002txm.3 uc002txn.3 uc002txl.3 uc002txo.3)

ENST00000414861 ENST00000430328 ENST00000498041 ENST00000454583 ENST00000457745

ENST00000484077 ENST00000467762 ENST00000433166

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIF1
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate RIF1 (see all 28):
		hsa-miR-4307 hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-503 hsa-miR-340 hsa-miR-218 hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: RIF1 3' UTR sequence

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Additional cDNA sequence: AL137363.1

12 DOTS entries:

DT.95080796 DT.111069 DT.424132 DT.95375555 DT.421672 DT.100642815 DT.100736202 DT.97824489

DT.100788823 DT.102824328 DT.91706270 DT.100644062

24/144 AceView cDNA sequences (see all 144):

BQ787643 BU192014 CR620638 AW957450 CB988725 CK902368 AU185993 CF264904

BC008115 BU172051 BM456124 BG282629 BM469792 AI123216 AI682290 AW451750

BX089321 AA335643 CR615710 BU181964 AA142902 BQ787820 BM989305 C04995

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RIF1 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	^
SP1:							-																		-
SP2:
SP3:
SP4:
SP5:

ExUns:	23	^	24	^	25	^	26	^	27	^	28a	·	28b
SP1:
SP2:
SP3:			-
SP4:
SP5:

ECgene alternative splicing isoforms for RIF1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RIF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTAGCTCTA

About this image

RIF1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RIF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIF1

SOURCE GeneReport for Unigene clusters: Hs.655671 Hs.735592

UniProtKB/Swiss-Prot: RIF1_HUMAN, Q5UIP0

Tissue specificity: Highly expressed in testis

SABiosciences Expression via Pathway-Focused PCR Array including RIF1:

Telomeres & Telomerase in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIF1 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rif1^{1 , 5}	Rap1 interacting factor 1 homolog (yeast)^{1, 5}	79.74(n)¹ 72.32(a)¹		2 (29.98 cM)⁵ 51869¹ NM_175238.5¹ NP_780447.4¹ 52072842⁵
chicken (Gallus gallus)	Aves	RIF1¹	RAP1 interacting factor homolog (yeast)	57.76(n) 50.18(a)		424316 XM_422162.3 XP_422162.3
lizard (Anolis carolinensis)	Reptilia	RIF1⁶	--	49(a)	1 ↔ 1	GL343302.1(1323562-1359339)
zebrafish (Danio rerio)	Actinopterygii	rif1¹	RAP1 interacting factor homolog (yeast)	50.09(n) 42.06(a)		567001 NM_001080806.1 NP_001074275.1
fruit fly (Drosophila melanogaster)	Insecta	CG30085⁶	--	16(a)	1 ↔ 1	2R(11751809-11756650)
rice (Oryza sativa)	Liliopsida	--	expressed protein	14(a)	1 ↔ 1	6(3681378-3687696)

ENSEMBL Gene Tree for RIF1 (if available)
TreeFam Gene Tree for RIF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146672108^1,2		--	152264500(+)	`AAAATC/TAGCTG`	3	--	us2k¹		0	--	--	--	--
rs7598855^1,2	C,F,	--	152264634(+)	`TAGAGC/TGAGAC`	4	--	us2k¹		2		NA	4
rs113289633^1,2	C,	--	152264635(+)	`AGAGCG/AAGACT`	4	--	us2k¹		1		WA	2
rs12373637^1,2		--	152264701(+)	`tatatA/Gtatat`	4	--	us2k¹		0	--	--	--	--
rs7574302^1,2	C,A	--	152264715(+)	`TATATA/GTATGT`	4	--	us2k¹		0	--	--	--	--
rs180711277^1,2		--	152264729(+)	`TGTGTA/GTATAT`	4	--	us2k¹		0	--	--	--	--
rs117737063^1,2	F,	--	152264821(+)	`ACTGCG/ATCGTT`	4	--	us2k¹		1		EA	120
rs76874460^1,2	C,F,	--	152264984(+)	`TGTCTG/CATTTA`	4	--	us2k¹		1		NA	120
rs185050955^1,2		--	152265034(+)	`GGCATA/GTGAAA`	4	--	us2k¹		0	--	--	--	--
rs116986536^1,2	F,	--	152265056(+)	`AGACCG/AGGCGC`	4	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for RIF1 (152266397 - 152364527 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RIF1
5 CNVs: 90079 1601 8961 1037 98015

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIF1

DNA2.0 Custom Variant and Variant Library Synthesis for RIF1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RIF1 for disorders           About GeneDecksing

OMIM gene information: 608952    OMIM disorders: --

4 diseases for RIF1:    About MalaCards

candida glabrata huntington's disease fibrosarcoma leukemia

Human Genome Epidemiology (HuGE) Navigator: RIF1 (3 documents)

Export disorders for RIF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RIF1 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with RIF1)

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Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. (PubMed id 15342490)^{1, 2, 3, 9} Silverman J.... De Lange T. (2004)
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. (PubMed id 15583028)^{1, 2, 9} Xu L. and Blackburn E.H. (2004)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{1, 2} Yu W.... Gibbs R.A. (1997)
Human RIF1 encodes an anti-apoptotic factor required for DNA repair. (PubMed id 19483192)^{1, 9} Wang H....Xu X. (2009)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)¹ Esteves S.L....da Cruz e Silva E.F. (2012)
Rif1 regulates the replication timing domains on the h uman genome. (PubMed id 22850674)¹ Yamazaki S....Masai H. (2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55183	HGNC: 23207	AceView: RIF1	Ensembl:ENSG00000080345	euGenes: HUgn55183
ECgene: RIF1	H-InvDB: RIF1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for RIF1	Pharmacogenomics, SNPs, Pathways

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RAP1 interacting factor homolog (yeast)

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RAP1 interacting factor homolog (yeast)

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