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Aliases for RIDA Gene

Aliases for RIDA Gene

  • Reactive Intermediate Imine Deaminase A Homolog 2 3 5
  • Heat-Responsive Protein 12 2 3 4
  • 14.5 KDa Translational Inhibitor Protein 3 4
  • Translational Inhibitor P14.5 2 3
  • UK114 Antigen Homolog 3 4
  • HRSP12 3 4
  • P14.5 3 4
  • PSP 3 4
  • Reactive Intermediate/Imine Deaminase A Homolog 2
  • Translational Inhibitor Protein P14.5 3
  • Perchloric Acid-Soluble Protein 3
  • Ribonuclease UK114 3
  • EC 3.1.-.- 4
  • UK114 3

External Ids for RIDA Gene

Previous HGNC Symbols for RIDA Gene

  • HRSP12

Summaries for RIDA Gene

GeneCards Summary for RIDA Gene

RIDA (Reactive Intermediate Imine Deaminase A Homolog) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RIDA Gene

  • Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).

Gene Wiki entry for RIDA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIDA Gene

Genomics for RIDA Gene

Regulatory Elements for RIDA Gene

Enhancers for RIDA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F098085 1 Ensembl ENCODE 10.9 +31.5 31451 0.4 PKNOX1 ARID4B SIN3A FEZF1 RAD21 RARA SCRT2 ZNF207 ZNF263 ZNF654 ERICH5 POP1 RIDA MATN2 RPS23P1 RPL30 SNORA72 ENSG00000245970 GC08P098099
GH08F098116 0.2 ENCODE 5.7 -0.5 -450 3.0 ATF1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 OSR2 RNU6-703P RPL30 MATN2 ENSG00000271930 MTDH RIDA POP1 GC08M098127
GH08F098151 0.5 Ensembl ENCODE 5 -35.5 -35503 3.3 CTCF KLF1 RFX1 RAD21 CHAMP1 ZFHX2 FOS ZBTB33 PRDM1 EGR2 MATN2 RIDA GC08P098161 GC08P098141
GH08F098113 0.2 ENCODE 0.8 +4.0 3974 0.1 YY1 RIDA GC08P098099
GH08F098115 1 Ensembl 0.8 +1.9 1941 0.2 ZNF121 ZNF316 EMSY MAFK RIDA GC08P098099
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RIDA on UCSC Golden Path with GeneCards custom track

Promoters for RIDA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001397207 -60 3000 ATF1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1

Genomic Location for RIDA Gene

Chromosome:
8
Start:
98,102,339 bp from pter
End:
98,117,241 bp from pter
Size:
14,903 bases
Orientation:
Minus strand

Genomic View for RIDA Gene

Genes around RIDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIDA Gene

Proteins for RIDA Gene

  • Protein details for RIDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52758-UK114_HUMAN
    Recommended name:
    Ribonuclease UK114
    Protein Accession:
    P52758
    Secondary Accessions:
    • Q6FHU9
    • Q6IBG0

    Protein attributes for RIDA Gene

    Size:
    137 amino acids
    Molecular mass:
    14494 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for RIDA Gene

neXtProt entry for RIDA Gene

Post-translational modifications for RIDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIDA Gene

No data available for DME Specific Peptides for RIDA Gene

Domains & Families for RIDA Gene

Suggested Antigen Peptide Sequences for RIDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52758

UniProtKB/Swiss-Prot:

UK114_HUMAN :
  • Belongs to the RutC family.
Family:
  • Belongs to the RutC family.
genes like me logo Genes that share domains with RIDA: view

No data available for Gene Families for RIDA Gene

Function for RIDA Gene

Molecular function for RIDA Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).

Enzyme Numbers (IUBMB) for RIDA Gene

Gene Ontology (GO) - Molecular Function for RIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016892 endoribonuclease activity, producing 3-phosphomonoesters IEA --
GO:0036041 long-chain fatty acid binding IEA --
genes like me logo Genes that share ontologies with RIDA: view
genes like me logo Genes that share phenotypes with RIDA: view

Animal Model Products

miRNA for RIDA Gene

miRTarBase miRNAs that target RIDA

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIDA Gene

Localization for RIDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIDA Gene

Cytoplasm. Nucleus. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear.

Gene Ontology (GO) - Cellular Components for RIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
GO:0005737 cytoplasm TAS 8530410
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RIDA: view

No data available for Subcellular locations from COMPARTMENTS for RIDA Gene

Pathways & Interactions for RIDA Gene

SuperPathways for RIDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0006449 regulation of translational termination TAS 8530410
GO:0007420 brain development IEA --
GO:0017148 negative regulation of translation IEA --
GO:0030324 lung development IEA --
genes like me logo Genes that share ontologies with RIDA: view

No data available for Pathways by source and SIGNOR curated interactions for RIDA Gene

Drugs & Compounds for RIDA Gene

(1) Drugs for RIDA Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzoic Acid Approved Pharma Target 7

(2) Additional Compounds for RIDA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RIDA: view

Transcripts for RIDA Gene

Unigene Clusters for RIDA Gene

Heat-responsive protein 12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIDA Gene

No ASD Table

Relevant External Links for RIDA Gene

GeneLoc Exon Structure for
RIDA
ECgene alternative splicing isoforms for
RIDA

Expression for RIDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of RIDA Gene:

RIDA

SOURCE GeneReport for Unigene cluster for RIDA Gene:

Hs.18426

mRNA Expression by UniProt/SwissProt for RIDA Gene:

P52758-UK114_HUMAN
Tissue specificity: Hepatocytes and renal distal tubular epithelial cells. Only weak expression in other tissues.
genes like me logo Genes that share expression patterns with RIDA: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RIDA Gene

Orthologs for RIDA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HRSP12 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToMany
HRSP12 34
  • 90.27 (n)
-- 35
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia HRSP12 34 35
  • 87.35 (n)
oppossum
(Monodelphis domestica)
Mammalia HRSP12 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HRSP12 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hrsp12 34 35
  • 84.94 (n)
Rida 16
rat
(Rattus norvegicus)
Mammalia Hrsp12 34
  • 84.67 (n)
chicken
(Gallus gallus)
Aves HRSP12 34 35
  • 72.47 (n)
lizard
(Anolis carolinensis)
Reptilia HRSP12 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hrp12 34
  • 70.1 (n)
Str.2950 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8312 34
zebrafish
(Danio rerio)
Actinopterygii hrsp12 34 35
  • 70.12 (n)
Dr.18514 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12324 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005327 34
  • 52.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta UK114 34 35
  • 52.07 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C23G10.2 34
  • 64.32 (n)
C23G10.2 35
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMF1 34 35
  • 51.3 (n)
MMF1 35 37
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G20390 34
  • 57.67 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7313 34
rice
(Oryza sativa)
Liliopsida Os07g0516200 34
  • 57.1 (n)
Species where no ortholog for RIDA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIDA Gene

ENSEMBL:
Gene Tree for RIDA (if available)
TreeFam:
Gene Tree for RIDA (if available)

Paralogs for RIDA Gene

Pseudogenes.org Pseudogenes for RIDA Gene

genes like me logo Genes that share paralogs with RIDA: view

No data available for Paralogs for RIDA Gene

Variants for RIDA Gene

Sequence variations from dbSNP and Humsavar for RIDA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10087186 -- 98,106,734(+) AAAAC(A/G)ATATT intron-variant
rs10088925 -- 98,115,849(+) AAGTT(C/T)CCTTT intron-variant, upstream-variant-2KB
rs1026653 -- 98,105,304(-) CTGAA(A/G)AAATT intron-variant
rs10576507 -- 98,114,328(+) AAATC(-/T)TTTTT intron-variant
rs10715342 -- 98,114,175(+) CAGCG(-/A)AACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIDA Gene

Variant ID Type Subtype PubMed ID
nsv1031795 CNV loss 25217958
nsv465745 CNV gain 19166990
nsv465746 CNV gain 19166990
nsv465747 CNV gain 19166990
nsv611805 CNV gain 21841781
nsv611806 CNV gain 21841781
nsv611807 CNV gain 21841781
nsv831405 CNV gain 17160897

Variation tolerance for RIDA Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIDA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIDA Gene

Disorders for RIDA Gene

Relevant External Links for RIDA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIDA

No disorders were found for RIDA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIDA Gene

Publications for RIDA Gene

  1. Isolation and characterization of a 14.5-kDa trichloroacetic-acid- soluble translational inhibitor protein from human monocytes that is upregulated upon cellular differentiation. (PMID: 8973653) Schmiedeknecht G. … Schmitz G. (Eur. J. Biochem. 1996) 2 3 4 22 64
  2. Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions. (PMID: 22094463) Lambrecht J.A. … Downs D.M. (J. Biol. Chem. 2012) 2 3 64
  3. Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro. (PMID: 20817725) Lambrecht J.A. … Downs D.M. (J. Biol. Chem. 2010) 2 3 64
  4. Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF. (PMID: 16198412) Mistiniene E. … Naktinis V. (Int. J. Biol. Macromol. 2005) 3 22 64
  5. Crystal structure of Homo sapiens protein hp14.5. (PMID: 14997576) Manjasetty B.A. … Heinemann U. (Proteins 2004) 3 4 64

Products for RIDA Gene

Sources for RIDA Gene

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