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Aliases & Descriptions for RICTOR
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686B11164 2 | | KIAA1999 2, 3 | | MGC39830 2 | | mAVO3 2 | | pianissimo 2 |
| | | Descriptions |
|---|
| TORC2-specific protein AVO3 2 | | rapamycin-insensitive companion of mTOR 2 |
|
| | Search outside databases for aliases for RICTOR gene |
Summaries for RICTOR(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RICTOR: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM] UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327Function: Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organizationGene Wiki entry for RICTOR |
Genomic Location for RICTOR
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RICTOR gene 
Entrez Gene cytogenetic band: 5p13.1 Ensembl cytogenetic band: 5p13.1 RICTOR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M038977:
(about GC identifiers)
Start:
|
38,973,779 bp from pter |
End:
|
39,110,260 bp from pter |
Size:
|
136,482 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000005.8 NT_006576.15
| Proteins for RICTOR
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327 (See
protein sequence)Recommended Name: Rapamycin-insensitive companion of mTOR Size: 1708 amino acids; 192218 Da
Subunit: Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2
Sequence caution: Sequence=CAH18135.1; Type=Frameshift; Positions=251;
Secondary accessions: B2RNX0 Q68DT5 Q86UB7 Q8N3A0 Q8NCM6Alternative splicing: 3 isoforms: Q6R327-1 Q6R327-2 Q6R327-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_689969.2
ENSEMBL proteins: ENSP00000296782 ENSP00000349959
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RICTOR: Assays for RICTOR: | Protein
Domains/ Families for RICTOR(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6R327
ProtoNet protein and cluster: Q6R327 UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327Similarity: Belongs to the pianissimo family | Gene Function for RICTOR
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152756
Applied Biosystems Silencer® siRNAs for RICTOR
Sigma-Aldrich siRNA for RICTOR  Sigma-Aldrich shRNA for RICTOR  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152756                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152756                                  untagged cDNA clone in CMV expression vector: NM_152756 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_152756
UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327Function: Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization8 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Rictor):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RICTOR
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for RICTOR 
5/29 Interacting proteins for RICTOR (ENSP000003499593 Q6R3271, 2) via UniProtKB, MINT, and/or STRING (see all 29
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for RICTOR(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RICTOR
|
Transcripts for RICTOR(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152756
Sigma-Aldrich siRNA for RICTOR  Sigma-Aldrich shRNA for RICTOR  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_152756 REFSEQ mRNAs for RICTOR gene: NM_152756.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_152756               OriGene GFP tagged cDNA clone in CMV expression vector: NM_152756                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152756                                  untagged cDNA clone in CMV expression vector: NM_152756  Additional cDNA sequence: AB082530.1 AK024327.1 AK094538.1 AK127305.1 AK128358.1 AL834497.1 AY515854.1 BC029608.1 BC051729.1 BC137163.1 BC137164.1 BC144509.1 CR749280.1 10 DOTS entries: DT.309782 DT.40269453 DT.91946497 DT.120872839 DT.101978363 DT.100727433 DT.100821095 DT.100821106 DT.101974663 DT.91664725 24/166 AceView cDNA sequences (see all 166
):AI004257 AK094538 AK024327 AI956142 AW293064 AA629107 AI278480 AA969170 AW189422 AW074672 AI400550 CB243634 AI753066 BM784969 BE049327 AI925493 AB082530 BQ024546 BX497451 AI291462 CB146809 AA825726 AA769047 AA994533
highest scoring ESTs for RICTOR:AI753066 AL042297 AY515854 BC029608 W49628 AA046051 AA046177 AA147549 AA156421 AA214713 Unigene Cluster for RICTOR: Rapamycin-insensitive companion of mTOR Hs.407926 [show with all ESTs]Unigene Representative Sequence: NM_152756
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000296782
ENST00000357387
|
Expression for RICTOR
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RICTOR expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RICTOR
1 / 2 / 3 11 probe-sets matching RICTOR gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGTTTCTTCT
SOURCE GeneReport for Unigene cluster: Hs.407926
|
Orthologs for RICTOR
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RICTOR gene from 5/8 species (see all 8
)
About this table Species with no ortholog for RICTOR
ENSEMBL Gene Tree for RICTOR | Paralogs for RICTOR(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for RICTOR(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RICTOR (up to first 250kb)
|
Disorders & Mutations for RICTOR
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609022
1 Novoseek disease relationship for RICTOR gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0.00 |
1 |
18089801 (1) |
About this table
|
Medical News for RICTOR(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RICTOR (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/39 PubMed articles for RICTOR gene (see all 39
):- Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)1, 3, 4 Sarbassov D.D.... Sabatini D.M. (2005)
- Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)3, 4 Pearce L.R.... Alessi D.R. (2007)
- Rictor, a novel binding partner of mTOR, defines a rapamycin- insensitive and raptor-independent pathway that regulates the cytoskeleton. (PubMed id 15268862)3, 4 Sarbassov D.D.... Sabatini D.M. (2004)
- Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)3, 4 Ohara O.... Koseki H. (2002)
- mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. (PubMed id 18089801)1, 3 Masri J....Gera J. (2007)
- ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells. (PubMed id 17329400)1, 3 Fuchs B.C....Bode B.P. (2007)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- Hsp70 associates with Rictor and is required for mTORC2 formation and activity. (PubMed id 18505677)3 Martin J....Gera J. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
|
Search for RICTOR
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RICTOR
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RICTOR
(According to HUGE)
About This Section
| |
Specialized Databases showing RICTOR(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RICTOR(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RICTOR:

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Incremental update: 13 Oct 2009
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