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RICTOR Gene

protein-coding GIFtS: 63
GCID: GC05M038939

RPTOR Independent Companion Of MTOR, Complex 2

See RICTOR-related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
RPTOR Independent Companion Of MTOR, Complex 2¹ ²		AVO3²
pianissimo¹ ²		PIA²
Rapamycin-Insensitive Companion Of MTOR¹ ²		TORC2-Specific Protein AVO3²
AVO3 Homolog² ³		KIAA1999³
hAVO3² ³

External Ids:	HGNC: 28611¹	Entrez Gene: 253260²	Ensembl: ENSG00000164327⁷	OMIM: 609022⁵	UniProtKB: Q6R327³

Export aliases for RICTOR gene to outside databases

Previous GC identifer: GC05M038977

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RICTOR Gene:

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth

factor-derived signals to regulate cell growth (Sarbassov et al., 2004 (PubMed 15268862)).(supplied by OMIM, Mar

2008)

GeneCards Summary for RICTOR Gene:

RICTOR (RPTOR independent companion of MTOR, complex 2) is a protein-coding gene. Diseases associated with RICTOR include foramen magnum meningioma. GO annotations related to this gene include ribosome binding.

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327

Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is

activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to

function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type

guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.

mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the

activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the

phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an

essential role in embryonic growth and development

Gene Wiki entry for RICTOR Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000005.9 NT_006576.17 NC_018916.2

Regulatory elements:

Regulatory transcription factor binding sites in the RICTOR gene promoter:
C/EBPbeta AML1a FOXF2 HSF1 (long) GATA-2 Meis-1b Sox9 HSF1short Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RICTOR promoter sequence

Search Chromatin IP Primers for RICTOR

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RICTOR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1 Ensembl cytogenetic band: 5p13.1 HGNC cytogenetic band: 5p13.1

RICTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RICTOR gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M038939: view genomic region (about GC identifiers)

Start:	38,938,021 bp from pter	End:	39,074,510 bp from pter
Size:	136,490 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327 (See protein sequence)

Recommended Name: Rapamycin-insensitive companion of mTOR

Size: 1708 amino acids; 192218 Da

Subunit: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR,

MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds

directly to MTOR and PRR5 within the TORC2 complex. Interacts with CCDC28B and NBN. May interact with PRR5L

Sequence caution: Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS;

Secondary accessions: B2RNX0 B7ZMF7 Q68DT5 Q86UB7 Q8N3A0 Q8NCM6

Alternative splicing: 3 isoforms: Q6R327-1 Q6R327-4 Q6R327-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RICTOR: NX_Q6R327

Explore proteomics data for RICTOR at MOPED

Post-translational modifications:

Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR

inhibits mTORC2 and AKT1 signaling¹

Ubiquitination² at Lys1391

Modification sites at PhosphoSitePlus

See RICTOR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001272368.1 NP_001272369.1 NP_689969.2

ENSEMBL proteins:

ENSP00000349959 ENSP00000423019 ENSP00000296782 ENSP00000423162

Reactome Protein details: Q6R327

RICTOR Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for RICTOR
	GenScript Custom Purified and Recombinant Proteins Services for RICTOR
	Novus Biologicals RICTOR Protein Novus Biologicals RICTOR Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for RICTOR
	antibodies-online proteins for RICTOR (2 products)
	antibodies-online peptides for RICTOR

RICTOR Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RICTOR
	R&D Systems Antibodies for RICTOR
	Cell Signaling Technology (CST) Antibodies for RICTOR
	OriGene Antibodies for RICTOR OriGene Custom Antibody Services for RICTOR
	Novus Biologicals RICTOR Antibodies
	Abcam antibodies for RICTOR
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for RICTOR
	antibodies-online antibodies for RICTOR (100 products)

RICTOR Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RICTOR
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RICTOR
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for RICTOR
	antibodies-online kits for RICTOR (2 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:

IPR028268 Pianissimo_fam

IPR011989 ARM-like

IPR028272 RICTOR

IPR028267 Pianissimo_N

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q6R327

ProtoNet protein and cluster: Q6R327

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327

Similarity: Belongs to the pianissimo family

Find genes that share domains with RICTOR About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: RICTR_HUMAN, Q6R327

Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is

activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to

function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type

guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.

mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the

activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the

phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an

essential role in embryonic growth and development

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	15467718
GO:0043022	ribosome binding	IEA	--

Find genes that share ontologies with RICTOR About GenesLikeMe

Phenotypes:
3 GenomeRNAi human phenotypes for RICTOR:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Selected MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Rictor) (see all 16):

adipose tissue	cardiovascular system	cellular	embryogenesis	endocrine/exocrine gland
growth/size/body	hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system
mortality/aging	muscle	renal/urinary system	reproductive system	skeleton

Find genes that share phenotypes with RICTOR About GenesLikeMe

Animal Models:
MGI mouse knock-out Rictor^tm1.2Mgn for RICTOR

genOway: Develop your customized and physiologically relevant rodent model for RICTOR

miRNA Products:		miRTarBase miRNAs that target RICTOR: hsa-mir-218-5p (MIRT006105), hsa-mir-31-3p (MIRT038935), hsa-mir-335-5p (MIRT018260), hsa-mir-18a-5p (MIRT050668), hsa-mir-155-5p (MIRT020841)

		Block miRNA regulation of human, mouse, rat RICTOR using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate RICTOR (see all 137):
		hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e

		SwitchGear 3'UTR luciferase reporter plasmid: RICTOR 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RICTOR
		Predesigned siRNA for gene silencing in human, mouse, rat RICTOR

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RICTOR

Clone Products:		OriGene clones in human, mouse for RICTOR (see all 5) OriGene ORF clones in mouse, rat for RICTOR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR
		Addgene plasmids for RICTOR

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RICTOR
		Browse ESI BIO Cell Lines and PureStem Progenitors for RICTOR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	4
nucleus	3
cytoskeleton	2
extracellular	2
plasma membrane	2
mitochondrion	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0031932	TORC2 complex	IDA	15268862

Find genes that share ontologies with RICTOR About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RICTOR About (see all 18)

See pathways by source

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by

SuperPath

Selected contained pathways About (see all per SuperPath)

PI-3K cascade

PI3K/AKT activation	0.93	PI3K events in ERBB4 signaling	0.88
GAB1 signalosome	0.93	PI3K events in ERBB2 signaling	0.88
PI-3K cascade	0.88	Role of LAT2/NTAL/LAB on calcium mobilization	0.80
Constitutive PI3K/AKT Signaling in Cancer	0.88	Signaling by SCF-KIT	0.72

Signaling by FGFR

Signaling by FGFR	0.91	DAP12 interactions	0.89
Signaling by FGFR in disease	0.91	Signaling by PDGF	0.87
Downstream signaling of activated FGFR	0.91	Signaling by EGFR	0.83
Downstream signal transduction	0.90	Signaling by EGFR in Cancer	0.82

CD28 co-stimulation

	CD28 co-stimulation	0.66			Costimulation by the CD28 family	0.44
	CD28 dependent PI3K/Akt signaling	0.66

Downstream Signaling Events Of B Cell Receptor (BCR)

Downstream Signaling Events Of B Cell Receptor (BCR)

0.79

Signaling by the B Cell Receptor (BCR)

0.79

Signaling by GPCR

Signal Transduction

0.58

Find genes that share SuperPaths with RICTOR About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for RICTOR

Akt Signaling Pathway

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RICTOR

mTOR Pathway

1 Cell Signaling Technology (CST) Pathway for RICTOR

Translational Control

Selected BioSystems Pathways for RICTOR (see all 8)

	TOR signaling
	Oncostatin M Signaling Pathway
	Prostate Cancer
	mTOR signaling pathway
	Class I PI3K signaling events mediated by Akt

3 Reactome Pathways for RICTOR

	Constitutive PI3K/AKT Signaling in Cancer
	PIP3 activates AKT signaling
	CD28 dependent PI3K/Akt signaling

1 Kegg Pathway (Kegg details for RICTOR):

mTOR signaling pathway

Pathway & Disease-focused RT² Profiler PCR Array including RICTOR:

mTOR Signaling in human mouse rat

Interactions:

GeneGlobe Interaction Network for RICTOR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RICTOR (Q6R327^{1, 2, 3} ENSP00000349959⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 230)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4H	P62805³, ENSP00000289352⁴	I2D: score=4 STRING: ENSP00000289352
HIST1H4F	P62805³, ENSP00000366974⁴	I2D: score=4 STRING: ENSP00000366974
HIST1H4A	P62805³	I2D: score=4
HIST1H4B	P62805³	I2D: score=4
HIST1H4C	P62805³	I2D: score=4

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Gene Ontology (GO): Selected biological process terms (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS	--
GO:0009790	embryo development	ISS	--
GO:0030334	regulation of cell migration	--	--

Find genes that share ontologies with RICTOR About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for RICTOR (RICTR)

1 Novoseek inferred chemical compound relationship for RICTOR gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rapamycin	87.1	19	19934294 (2), 19995915 (2), 19153210 (1), 19641186 (1) (see all 11)

Find genes that share compounds with RICTOR About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RICTOR gene (3 alternative transcripts):

NM_001285439.1 NM_001285440.1 NM_152756.4

Unigene Cluster for RICTOR:

RPTOR independent companion of MTOR, complex 2

Hs.407926 [show with all ESTs]

Unigene Representative Sequence: NM_152756

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000357387(uc003jlp.2 uc003jlo.2 uc010ivf.2) ENST00000511516

ENST00000296782 ENST00000505927 ENST00000503698 ENST00000509567 ENST00000515846

ENST00000510711(uc003jlq.1) ENST00000513566(uc011cpk.1) ENST00000514735

miRNA Products:		Block miRNA regulation of human, mouse, rat RICTOR using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate RICTOR (see all 137):
		hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e

		SwitchGear 3'UTR luciferase reporter plasmid: RICTOR 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RICTOR
		Predesigned siRNA for gene silencing in human, mouse, rat RICTOR

Clone Products:		OriGene clones in human, mouse for RICTOR (see all 5) OriGene ORF clones in mouse, rat for RICTOR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR
		Addgene plasmids for RICTOR

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for RICTOR
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RICTOR
		QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
		QuantiFast Probe-based Assays in human, mouse, rat RICTOR

Additional mRNA sequence:

AB082530.1 AK024327.1 AK094538.1 AK127305.1 AK128358.1 AL834497.1 AY515854.1 BC029608.1

BC051729.1 BC137163.1 BC137164.1 BC144509.1 CR749280.1

10 DOTS entries:

DT.309782 DT.40269453 DT.91946497 DT.120872839 DT.101978363 DT.100727433 DT.100821095 DT.100821106

DT.101974663 DT.91664725

Selected AceView cDNA sequences (see all 166):

AW189422 BQ024546 AA629107 BX497451 AI278480 AB082530 AI004257 AK094538

AJ705834 AW074672 AA825726 CB146809 CB243634 BQ228640 AI925493 AW293064

AA355244 AI400550 AI291462 BM784969 AK024327 BE049327 BX497450 AA969170

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RICTOR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGTTTCTTCT

About this image

RICTOR expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Blood (Hematopoietic System)
Granulocytes Peripheral Blood

RICTOR Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RICTOR Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.407926

Pathway & Disease-focused RT² Profiler PCR Array including RICTOR:

mTOR Signaling in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for RICTOR
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RICTOR
		QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
		QuantiFast Probe-based Assays in human, mouse, rat RICTOR

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for RICTOR gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rictor^{1 , 5}	RPTOR independent companion of MTOR, complex 2^{1, 5}	88.46(n)¹ 95.49(a)¹		15 (3.25 cM)⁵ 78757¹ NM_030168.3¹ NP_084444.3¹ 6708381⁵
chicken (Gallus gallus)	Aves	RICTOR¹	RPTOR independent companion of MTOR, complex 2	80.38(n) 87.57(a)		427447 XM_003642978.2 XP_003643026.1
lizard (Anolis carolinensis)	Reptilia	RICTOR⁶	RPTOR independent companion of MTOR, complex 2	84(a)	1 ↔ 1	GL343241.1(7680-69695)
tropical clawed frog (Xenopus tropicalis)	Amphibia	rictor¹	RPTOR independent companion of MTOR, complex 2	74.93(n) 82.82(a)		100485588 XM_002938193.2 XP_002938239.2
zebrafish (Danio rerio)	Actinopterygii	rictorb¹	rapamycin-insensitive companion of mTOR b	68.63(n) 76.6(a)		561835 XM_001921872.2 XP_001921907.2
fruit fly (Drosophila melanogaster)	Insecta	rictor⁶	rapamycin-insensitive companion of Tor	21(a)	1 ↔ 1	X(19146144-19155259)
worm (Caenorhabditis elegans)	Secernentea	rict-1⁶	Protein RICT-1, isoform a (rict-1) mRNA, complete ...	17(a)	1 ↔ 1	II(13098249-13116801) WBGene00009245
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TSC11(YER093C)⁴	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), more	--		5(347612-343320) 856828 NP_011018.1

ENSEMBL Gene Tree for RICTOR (if available)
TreeFam Gene Tree for RICTOR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186445093^1,2		--	38937949(+)	`GCATCA/GGCATT`	1	--	ds500¹		0	--	--	--	--
rs116898658^1,2	F	--	38938266(+)	`TACAAT/CATAAA`	1	--	ut3¹		1		EA	120
rs146274682^1,2	C	--	38938422(+)	`AAACTA/GGTTTA`	1	--	ut3¹		0	--	--	--	--
rs10941413^1,2	C,F,H	--	38938664(+)	`CAGCTA/GTCCGA`	1	--	ut3¹		22		NA NS EA	2780
rs139177258^1,2	C	--	38938736(+)	`CCTACC/TAGGAA`	1	--	ut3¹		0	--	--	--	--
rs191215862^1,2		--	38939108(+)	`AAAGAA/GCATTT`	1	--	ut3¹		0	--	--	--	--
rs183334869^1,2		--	38939114(+)	`CATTTC/TCCAAA`	1	--	ut3¹		0	--	--	--	--
rs186218594^1,2		--	38939121(+)	`CAAAGA/TAGTTT`	1	--	ut3¹		0	--	--	--	--
rs191483620^1,2	C	--	38939176(+)	`CAAAAA/CTAACT`	1	--	ut3¹		0	--	--	--	--
rs79483477^1,2	C,F	--	38939209(+)	`ACAATT/CTGGTT`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for RICTOR (38938021 - 39074510 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for RICTOR: About this table

Variant ID	Type	Subtype	PubMed ID
esv2730111	CNV	Deletion	23290073
esv1576101	CNV	Insertion	17803354
nsv4802	CNV	Insertion	18451855
nsv528773	CNV	Loss	19592680
nsv4803	CNV	Loss	18451855
esv24079	CNV	Loss	19812545
nsv818346	CNV	Loss	17921354
nsv820160	CNV	Loss	19587683
nsv519072	CNV	Loss	19592680
nsv529023	CNV	Loss	19592680

3 Site Specific Mutation Identification with PCR Assays for RICTOR:

Cosmic Id	AA Change
24249	p.M675I
26588	p.T722A
24248	p.S159F

SeqTarget long-range PCR primers for resequencing RICTOR

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609022 OMIM disorders: --

1 disease for RICTOR:
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foramen magnum meningioma

1 inferred disease relationship from the University of Copenhagen DISEASES database for RICTOR:

Foramen magnum meningioma

Find genes that share disorders with RICTOR About GenesLikeMe

1 Novoseek inferred disease relationship for RICTOR gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	6.27	1	18089801 (1)

Genetic Association Database (GAD): RICTOR
Human Genome Epidemiology (HuGE) Navigator: RICTOR (2 documents)

Export disorders for RICTOR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RICTOR gene, integrated from 10 sources (see all 112):
(articles sorted by number of sources associating them with RICTOR)

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mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PubMed id 19995915)^{1, 2, 9} Julien L.A.... Roux P.P. (Mol. Cell. Biol. 2010)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)^{1, 2, 9} Sarbassov D.D.... Sabatini D.M. (Science 2005)
Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PubMed id 23762398)^{1, 2} Wang J.Q....Wu K.J. (PLoS ONE 2013)
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)^{1, 4} Zhang X....Wu X. (Carcinogenesis 2010)
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)^{1, 2} Pearce L.R.... Alessi D.R. (Biochem. J. 2007)
Rictor, a novel binding partner of mTOR, defines a rapamycin- insensitive and raptor-independent pathway that regulates the cytoskeleton. (PubMed id 15268862)^{1, 2} Sarbassov D.D.... Sabatini D.M. (Curr. Biol. 2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PubMed id 15467718)^{1, 2} Jacinto E....Hall M.N. (Nat. Cell Biol. 2004)
Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)^{1, 2} Ohara O.... Koseki H. (DNA Res. 2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. (PubMed id 18089801)^{1, 9} Masri J....Gera J. (Cancer Res. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 253260	HGNC: 28611	AceView: MGC39830	Ensembl:ENSG00000164327	euGenes: HUgn253260
ECgene: RICTOR	Kegg: 253260	H-InvDB: RICTOR

(According to HUGE)
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HUGE: KIAA1999

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RICTOR	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RICTOR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RICTOR gene:
Search GeneIP for patents involving RICTOR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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RPTOR Independent Companion Of MTOR, Complex 2

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RPTOR Independent Companion Of MTOR, Complex 2

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