Aliases for RICTOR Gene
Aliases for RICTOR Gene
External Ids for RICTOR Gene
- HGNC: 28611
- Entrez Gene: 253260
- Ensembl: ENSG00000164327
- OMIM: 609022
- UniProtKB: Q6R327
Previous GeneCards Identifiers for RICTOR Gene
- GC05M038977
Summaries for RICTOR Gene
-
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RICTOR Gene
RICTOR (RPTOR Independent Companion Of MTOR Complex 2) is a Protein Coding gene. Diseases associated with RICTOR include Bardet-Biedl Syndrome. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and RET signaling. Gene Ontology (GO) annotations related to this gene include binding and ribosome binding.
UniProtKB/Swiss-Prot for RICTOR Gene
-
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.
Additional gene information for RICTOR Gene
- Monarch Initiative
- Search for RICTOR at DataMed
- Search for RICTOR at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RICTOR Gene
Genomics for RICTOR Gene
GeneHancer (GH) Regulatory Elements for RICTOR Gene
Promoters and enhancers for RICTOR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RICTOR on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RICTOR Gene
Genomic Locations for RICTOR Gene
- chr5:38,937,919-39,074,419
- (GRCh38/hg38)
- Size:
- 136,501 bases
- Orientation:
- Minus strand
- chr5:38,938,021-39,074,510
- (GRCh37/hg19)
Genomic View for RICTOR Gene
Genes around RICTOR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.1 by Ensembl
- 5p13.1 by Entrez Gene
- 5p13.1 by HGNC
RICTOR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RICTOR Gene
Proteins for RICTOR Gene
-
Protein details for RICTOR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6R327-RICTR_HUMAN
- Recommended name:
- Rapamycin-insensitive companion of mTOR
- Protein Accession:
- Q6R327
- B2RNX0
- B7ZMF7
- Q68DT5
- Q86UB7
- Q8N3A0
- Q8NCM6
Protein attributes for RICTOR Gene
- Size:
- 1708 amino acids
- Molecular mass:
- 192218 Da
- Quaternary structure:
-
- Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex (PubMed:15268862, PubMed:17461779, PubMed:17599906). Interacts with CCDC28B (PubMed:23727834). Interacts with NBN (PubMed:23762398). Interacts with PRR5L (PubMed:17461779, PubMed:21964062).
- SequenceCaution:
-
- Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for RICTOR Gene
Post-translational modifications for RICTOR Gene
- Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
Other Protein References for RICTOR Gene
Antibody Products
- R&D Systems Antibodies for RICTOR (Rictor)
- Cell Signaling Technology (CST) Antibodies for RICTOR (RICTOR)
-
Custom Antibody ServicesOriGene Antibodies for RICTOR
- Novus Biologicals Antibodies for RICTOR
-
Abcam antibodies for RICTOR
- Invitrogen Antibodies for RICTOR
- antibodies-online: Search results for 194 available RICTOR Antibodies ranked by validation data
- Compare Top RICTOR Antibodies
-
Recommended
- 58 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 2 FACS Antibodies (anti-human)
- 6 IP Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 133 WB Antibodies (anti-human)
- 6 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- GeneTex RICTOR antibody for RICTOR
-
Santa Cruz Biotechnology (SCBT) Antibodies for RICTOR
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RICTOR
- Origene Custom Protein Services for RICTOR
- Search GeneTex for Proteins for RICTOR
-
Abcam proteins for RICTOR
Assay Products
No data available for DME Specific Peptides for RICTOR Gene
Domains & Families for RICTOR Gene
Gene Families for RICTOR Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RICTOR Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RICTOR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6R327- Family:
-
- Belongs to the RICTOR family.
Function for RICTOR Gene
Molecular function for RICTOR Gene
- UniProtKB/Swiss-Prot Function:
- Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.
Phenotypes From GWAS Catalog for RICTOR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15467718 |
| GO:0008047 | enzyme activator activity | IBA | -- |
| GO:0019901 | protein kinase binding | IPI | 21177249 |
| GO:0043022 | ribosome binding | IEA | -- |
Phenotypes for RICTOR Gene
- MGI mutant phenotypes for RICTOR:
-
inferred from 8 alleles
- homeostasis/metabolism phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for RICTOR:
-
- Increased vaccinia virus (VACV) infection
- Decreased POU5F1-GFP protein expression
- Decreased shRNA abundance (Z-score < -2)
- Decreased cell migration
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Increased cell migration
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RICTOR
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RICTOR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
- Search ViGene Biosciences for RICTOR
CRISPR Products
-
OriGene CRISPR knockouts for RICTOR
- genomics-online: gRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- Applied Biological Materials CRISPR for RICTOR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
- GenScript: Design CRISPR guide RNA sequences for RICTOR
miRNA for RICTOR Gene
- miRTarBase miRNAs that target RICTOR
-
- hsa-mir-218-5p (MIRT006105)
- hsa-mir-335-5p (MIRT018260)
- hsa-mir-155-5p (MIRT020841)
- hsa-mir-31-3p (MIRT038935)
- hsa-mir-18a-5p (MIRT050668)
- hsa-mir-34a-5p (MIRT054810)
- hsa-mir-6747-5p (MIRT166223)
- hsa-mir-3124-3p (MIRT391490)
- hsa-let-7c-5p (MIRT437348)
- hsa-mir-16-5p (MIRT437349)
- hsa-mir-142-3p (MIRT439769)
- hsa-mir-4665-5p (MIRT469189)
- hsa-mir-1275 (MIRT469190)
- hsa-mir-4472 (MIRT469191)
- hsa-mir-4447 (MIRT469192)
- hsa-mir-6769b-5p (MIRT469193)
- hsa-mir-6769a-5p (MIRT469194)
- hsa-mir-92a-2-5p (MIRT469195)
- hsa-mir-654-5p (MIRT469196)
- hsa-mir-541-3p (MIRT469197)
- hsa-mir-7110-5p (MIRT469198)
- hsa-mir-6842-5p (MIRT469199)
- hsa-mir-6752-5p (MIRT469200)
- hsa-mir-5010-5p (MIRT469201)
- hsa-mir-4525 (MIRT469202)
- hsa-mir-7111-5p (MIRT469203)
- hsa-mir-6870-5p (MIRT469204)
- hsa-mir-4723-5p (MIRT469205)
- hsa-mir-5698 (MIRT469206)
- hsa-mir-6825-5p (MIRT469207)
- hsa-mir-625-5p (MIRT469208)
- hsa-mir-6883-5p (MIRT469209)
- hsa-mir-6785-5p (MIRT469210)
- hsa-mir-4728-5p (MIRT469211)
- hsa-mir-149-3p (MIRT469212)
- hsa-mir-8069 (MIRT469213)
- hsa-mir-8062 (MIRT469214)
- hsa-mir-8079 (MIRT469215)
- hsa-mir-1245a (MIRT469216)
- hsa-mir-6841-5p (MIRT469217)
- hsa-mir-6732-5p (MIRT469218)
- hsa-mir-384 (MIRT654255)
- hsa-mir-3685 (MIRT654256)
- hsa-mir-6509-5p (MIRT654257)
- hsa-mir-202-5p (MIRT654258)
- hsa-mir-337-3p (MIRT654259)
- hsa-mir-3160-5p (MIRT654260)
- hsa-mir-3927-5p (MIRT654261)
- hsa-mir-500b-5p (MIRT654262)
- hsa-mir-362-5p (MIRT654263)
- hsa-mir-128-3p (MIRT733520)
- hsa-mir-153-5p (MIRT735419)
miRNA Products
- Search ViGene Biosciences for RICTOR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
- genomics-online: shRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RICTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RICTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RICTOR
- Applied Biological Materials Clones for RICTOR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RICTOR
-
ViGene Biosciences adenoviral particle packaged cDNA for RICTOR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RICTOR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RICTOR Gene
Localization for RICTOR Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0031932 | TORC2 complex | IDA,IEA | 15268862 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RICTOR Gene
Pathways & Interactions for RICTOR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | PI3K/AKT activation |
.89
|
|
| 3 | CD28 co-stimulation | ||
| 4 | mTOR signaling pathway (KEGG) | ||
| 5 | Constitutive Signaling by AKT1 E17K in Cancer | ||
Pathways by source for RICTOR Gene
1 GeneTex pathway for RICTOR Gene
1 Cell Signaling Technology pathway for RICTOR Gene
10 BioSystems pathways for RICTOR Gene
35 Reactome pathways for RICTOR Gene
1 KEGG pathway for RICTOR Gene
2 R&D Systems pathways for RICTOR Gene
1 Qiagen pathway for RICTOR Gene
Interacting Proteins for RICTOR Gene
Selected Interacting proteins:
Q6R327-RICTR_HUMAN
ENSP00000349959
for RICTOR Gene via
IID
MINT
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009790 | embryo development | ISS,IEA | -- |
| GO:0010468 | regulation of gene expression | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IGI | 21177249 |
Drugs & Compounds for RICTOR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| OSI-027 | Investigational | Pharma | inhibitor | MTORC1/ mTORC2 inhibitor, Kinase Inhibitors | 0 | |
| GDC-0349 | Investigational | Pharma | MTOR inhibitor | 0 | ||
| AZD2014 | Pharma | Novel mTOR inhibitor | 0 | |||
| GDC-0980 (RG7422) | Pharma | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 0 | |||
| INK 128 (MLN0128) | Pharma | MTOR(TORC-1/-2) inhibitor,potent and selective | 0 |
(12) ApexBio Compounds for RICTOR Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZD2014 | Novel mTOR inhibitor | 1009298-59-2 |
| GDC-0349 | MTOR inhibitor | 1207360-89-1 |
| GDC-0980 (RG7422) | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 1032754-93-0 |
| INK 128 (MLN0128) | MTOR(TORC-1/-2) inhibitor,potent and selective | 1224844-38-5 |
| KU-0063794 | MTORC1 and mTORC2 inhibitor | 938440-64-3 |
| OSI-027 | MTORC1/ mTORC2 inhibitor | 936890-98-1 |
| Ridaforolimus (Deforolimus, MK-8669) | MTOR inhibitor | 572924-54-0 |
| WAY-600 | MTOR inhibitor | 1062159-35-6 |
| WYE-125132 (WYE-132) | ATP-competitive mTOR inhibitor, highly potent | 1144068-46-1 |
| WYE-354 | MTOR inhibitor,potent,ATP-competitive and cell-permeable | 1062169-56-5 |
| WYE-687 | MTOR inhibitor,ATP-competitive and selective | 1062161-90-3 |
| XL388 | MTOR inhibitor,highly potent and selective | 1251156-08-7 |
Transcripts for RICTOR Gene
mRNA/cDNA for RICTOR Gene
- (11) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (166) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RICTOR Gene
CRISPR Products
-
OriGene CRISPR knockouts for RICTOR
- genomics-online: gRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
- Applied Biological Materials CRISPR for RICTOR
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
- GenScript: Design CRISPR guide RNA sequences for RICTOR
miRNA Products
- Search ViGene Biosciences for RICTOR
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
- genomics-online: shRNA clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RICTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RICTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RICTOR
- Applied Biological Materials Clones for RICTOR
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RICTOR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
This gene is overexpressed in Tlymphocyte (42.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RICTOR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RICTOR Gene:
RICTORSOURCE GeneReport for Unigene cluster for RICTOR Gene:
Hs.407926Evidence on tissue expression from TISSUES for RICTOR Gene
- Nervous system(4.6)
- Liver(4.3)
- Muscle(2.4)
- Heart(2.1)
- Kidney(2.1)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for RICTOR
- genomics-online: primer clones - Search results for 71 available RICTOR gene related products
- Overview of 71 available RICTOR gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RICTOR Gene
Orthologs for RICTOR Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RICTOR 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RICTOR 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RICTOR 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rictor 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RICTOR 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rictor 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RICTOR 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RICTOR 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RICTOR 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rictor 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | RICTOR (3 of 3) 34 |
|
OneToMany | |
| rictora 34 |
|
OneToMany | |||
| rictorb 33 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | rictor 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | rict-1 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TSC11 34 36 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2872 34 |
|
OneToOne |
- Species where no ortholog for RICTOR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RICTOR Gene
No data available for Paralogs for RICTOR Gene
Variants for RICTOR Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034056 | -- | 38,955,318(-) | A/G | intron_variant | |
| rs1000086489 | -- | 39,000,942(-) | A/T | intron_variant | |
| rs1000097359 | -- | 39,007,619(-) | C/A | intron_variant | |
| rs1000140204 | -- | 39,053,123(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000169585 | -- | 39,040,373(-) | C/G/T | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5636n100 | CNV | loss | 25217958 |
| dgv9730n54 | CNV | gain | 21841781 |
| esv1576101 | CNV | insertion | 17803354 |
| esv24079 | CNV | loss | 19812545 |
| esv2730111 | CNV | deletion | 23290073 |
| esv3418125 | CNV | insertion | 20981092 |
| esv3604775 | CNV | gain | 21293372 |
| esv3604776 | CNV | loss | 21293372 |
| esv3604777 | CNV | gain | 21293372 |
| nsv4802 | CNV | insertion | 18451855 |
| nsv4803 | CNV | deletion | 18451855 |
| nsv519072 | CNV | loss | 19592680 |
| nsv528773 | CNV | loss | 19592680 |
| nsv529023 | CNV | loss | 19592680 |
| nsv597860 | CNV | gain | 21841781 |
| nsv597861 | CNV | gain | 21841781 |
| nsv597862 | CNV | gain+loss | 21841781 |
| nsv597863 | CNV | gain | 21841781 |
| nsv597867 | CNV | gain | 21841781 |
| nsv597868 | CNV | loss | 21841781 |
| nsv597869 | CNV | gain | 21841781 |
| nsv597870 | CNV | loss | 21841781 |
| nsv818346 | CNV | loss | 17921354 |
| nsv820160 | CNV | loss | 19587683 |
| nsv950671 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
1.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.84;
93.46% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RICTOR Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RICTOR Gene
Disorders for RICTOR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bardet-biedl syndrome |
|
|
Search RICTOR in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RICTOR
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RICTOR Gene
Publications for RICTOR Gene
- mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PMID: 19995915) Julien LA … Roux PP (Molecular and cellular biology 2010) 3 4 22 58
- Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PMID: 15718470) Sarbassov DD … Sabatini DM (Science (New York, N.Y.) 2005) 3 4 22 58
- Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PMID: 23762398) Wang JQ … Wu KJ (PloS one 2013) 3 4 58
- Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. (PMID: 21964062) Holmes B … Gera J (Cellular signalling 2012) 3 4 58
- MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
Products for RICTOR Gene
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- genomics-online: cdna clones - Search results for 71 available RICTOR gene related products
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Sources for RICTOR Gene
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