Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RICTOR Gene

Aliases for RICTOR Gene

  • RPTOR Independent Companion Of MTOR, Complex 2 2 3
  • Rapamycin-Insensitive Companion Of MTOR 2 3
  • AVO3 Homolog 3 4
  • Pianissimo 2 3
  • HAVO3 3 4
  • TORC2-Specific Protein AVO3 3
  • KIAA1999 4
  • AVO3 3
  • PIA 3

External Ids for RICTOR Gene

Summaries for RICTOR Gene

Entrez Gene Summary for RICTOR Gene

  • RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RICTOR Gene

RICTOR (RPTOR Independent Companion Of MTOR, Complex 2) is a Protein Coding gene. Diseases associated with RICTOR include foramen magnum meningioma. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include ribosome binding.

UniProtKB/Swiss-Prot for RICTOR Gene

  • Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.

Gene Wiki entry for RICTOR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RICTOR Gene

Genomics for RICTOR Gene

Genomic Location for RICTOR Gene

Start:
38,937,919 bp from pter
End:
39,074,408 bp from pter
Size:
136,490 bases
Orientation:
Minus strand

Genomic View for RICTOR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RICTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RICTOR Gene

Regulatory Elements for RICTOR Gene

Proteins for RICTOR Gene

  • Protein details for RICTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6R327-RICTR_HUMAN
    Recommended name:
    Rapamycin-insensitive companion of mTOR
    Protein Accession:
    Q6R327
    Secondary Accessions:
    • B2RNX0
    • B7ZMF7
    • Q68DT5
    • Q86UB7
    • Q8N3A0
    • Q8NCM6

    Protein attributes for RICTOR Gene

    Size:
    1708 amino acids
    Molecular mass:
    192218 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex. Interacts with CCDC28B and NBN. May interact with PRR5L.
    SequenceCaution:
    • Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for RICTOR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RICTOR Gene

Proteomics data for RICTOR Gene at MOPED

Post-translational modifications for RICTOR Gene

  • Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1391

Other Protein References for RICTOR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RICTOR Gene

Domains for RICTOR Gene

Protein Domains for RICTOR Gene

UniProtKB/Swiss-Prot:

RICTR_HUMAN
Family:
  • Belongs to the pianissimo family.:
    • Q6R327
genes like me logo Genes that share domains with RICTOR: view

No data available for Gene Families for RICTOR Gene

Function for RICTOR Gene

Molecular function for RICTOR Gene

UniProtKB/Swiss-Prot Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.

Gene Ontology (GO) - Molecular Function for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 15467718
GO:0019901 protein kinase binding IPI 21177249
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with RICTOR: view
genes like me logo Genes that share phenotypes with RICTOR: view

Animal Models for RICTOR Gene

MGI Knock Outs for RICTOR:

miRNA for RICTOR Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RICTOR Gene

Localization for RICTOR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RICTOR Gene COMPARTMENTS Subcellular localization image for RICTOR gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
extracellular 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031932 TORC2 complex IDA 15268862
genes like me logo Genes that share ontologies with RICTOR: view

Pathways for RICTOR Gene

genes like me logo Genes that share pathways with RICTOR: view

Pathways by source for RICTOR Gene

1 R&D Systems pathway for RICTOR Gene
1 Qiagen pathway for RICTOR Gene
1 Cell Signaling Technology pathway for RICTOR Gene

Gene Ontology (GO) - Biological Process for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0009790 embryo development ISS --
GO:0018105 peptidyl-serine phosphorylation IGI 21177249
genes like me logo Genes that share ontologies with RICTOR: view

Compounds for RICTOR Gene

(1) Novoseek inferred chemical compound relationships for RICTOR Gene

Compound -log(P) Hits PubMed IDs
rapamycin 87.1 13
genes like me logo Genes that share compounds with RICTOR: view

Transcripts for RICTOR Gene

Unigene Clusters for RICTOR Gene

RPTOR independent companion of MTOR, complex 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RICTOR Gene

No ASD Table

Relevant External Links for RICTOR Gene

GeneLoc Exon Structure for
RICTOR
ECgene alternative splicing isoforms for
RICTOR

Expression for RICTOR Gene

mRNA expression in normal human tissues for RICTOR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RICTOR Gene

SOURCE GeneReport for Unigene cluster for RICTOR Gene Hs.407926

genes like me logo Genes that share expressions with RICTOR: view

Orthologs for RICTOR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RICTOR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RICTOR 36
  • 99.46 (n)
  • 99.54 (a)
RICTOR 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RICTOR 36
  • 94.16 (n)
  • 97.89 (a)
RICTOR 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RICTOR 36
  • 94.45 (n)
  • 98.35 (a)
RICTOR 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rictor 36
  • 88.46 (n)
  • 95.49 (a)
Rictor 16
Rictor 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RICTOR 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RICTOR 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rictor 36
  • 89.08 (n)
  • 96.74 (a)
chicken
(Gallus gallus)
Aves RICTOR 36
  • 80.38 (n)
  • 87.57 (a)
RICTOR 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RICTOR 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rictor 36
  • 74.93 (n)
  • 82.82 (a)
zebrafish
(Danio rerio)
Actinopterygii RICTOR (3 of 3) 37
  • 81 (a)
OneToMany
rictora 37
  • 73 (a)
OneToMany
rictorb 36
  • 68.63 (n)
  • 76.6 (a)
rictorb 37
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta rictor 37
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rict-1 37
  • 17 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSC11 37
  • 18 (a)
OneToOne
TSC11 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2872 37
  • 39 (a)
OneToOne
Species with no ortholog for RICTOR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RICTOR Gene

ENSEMBL:
Gene Tree for RICTOR (if available)
TreeFam:
Gene Tree for RICTOR (if available)

Paralogs for RICTOR Gene

No data available for Paralogs for RICTOR Gene

Variants for RICTOR Gene

Sequence variations from dbSNP and Humsavar for RICTOR Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10315 -- 38,938,241(-) TTTTT(A/T)TTTAG utr-variant-3-prime
rs358517 -- 39,046,013(-) AGCTA(A/G)TGAAA intron-variant
rs358518 -- 39,045,999(-) ACTGA(A/C)GATCC intron-variant
rs401259 -- 38,941,207(-) TGCAG(G/T)GGTAG utr-variant-3-prime
rs443039 -- 38,940,756(+) TCAGT(G/T)CCAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RICTOR Gene

Variant ID Type Subtype PubMed ID
nsv820160 CNV Loss 19587683
nsv529023 CNV Loss 19592680
nsv4802 CNV Insertion 18451855
esv1576101 CNV Insertion 17803354
nsv528773 CNV Loss 19592680
nsv519072 CNV Loss 19592680
nsv818346 CNV Loss 17921354
nsv4803 CNV Loss 18451855
esv2730111 CNV Deletion 23290073
esv24079 CNV Loss 19812545

Relevant External Links for RICTOR Gene

HapMap Linkage Disequilibrium report
RICTOR

Disorders for RICTOR Gene

(1) MalaCards Diseases for RICTOR Gene

Search for RICTOR Gene in MalaCards »

(1) University of Copenhagen DISEASES for RICTOR Gene

(1) Novoseek inferred disease relationships for RICTOR Gene

Disease -log(P) Hits PubMed IDs
tumors 6.27 1

Relevant External Links for RICTOR

Genetic Association Database (GAD)
RICTOR
Human Genome Epidemiology (HuGE) Navigator
RICTOR
genes like me logo Genes that share disorders with RICTOR: view

No data available for UniProtKB/Swiss-Prot for RICTOR Gene

Publications for RICTOR Gene

  1. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PMID: 15718470) Sarbassov D.D. … Sabatini D.M. (Science 2005) 3 4 23
  2. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PMID: 19995915) Julien L.A. … Roux P.P. (Mol. Cell. Biol. 2010) 3 4 23
  3. Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility. (PMID: 19724909) Gulati N. … Jhanwar-Uniyal M. (Int. J. Oncol. 2009) 3 23
  4. Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer. (PMID: 19934294) Gulhati P. … Evers B.M. (Clin. Cancer Res. 2009) 3 23
  5. ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells. (PMID: 17329400) Fuchs B.C. … Bode B.P. (Am. J. Physiol., Cell Physiol. 2007) 3 23

Products for RICTOR Gene

Sources for RICTOR Gene

Back to Top

Content