Aliases for RICTOR Gene
Aliases for RICTOR Gene
External Ids for RICTOR Gene
- HGNC: 28611
- Entrez Gene: 253260
- Ensembl: ENSG00000164327
- OMIM: 609022
- UniProtKB: Q6R327
Previous GeneCards Identifiers for RICTOR Gene
- GC05M038977
Summaries for RICTOR Gene
-
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RICTOR Gene
RICTOR (RPTOR Independent Companion Of MTOR Complex 2) is a Protein Coding gene. Diseases associated with RICTOR include Bardet-Biedl Syndrome. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and Regulation of TP53 Activity. GO annotations related to this gene include binding and ribosome binding.
UniProtKB/Swiss-Prot for RICTOR Gene
-
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RICTOR Gene
Genomics for RICTOR Gene
Regulatory Elements for RICTOR Gene
Enhancers for RICTOR Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G039072 | 1.8 | FANTOM5 ENCODE dbSUPER | 39.7 | -0.6 | -589 | 5.9 | DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D RCOR2 NBN KDM1A | RICTOR FYB OSMR GC05M039105 |
| GH05G038806 | 1.6 | Ensembl ENCODE dbSUPER | 15.9 | +265.8 | 265758 | 4.6 | PKNOX1 SIN3A FEZF1 ZNF2 ZNF766 ZNF302 CBX5 ZNF143 ZNF548 FOS | RICTOR ENSG00000248234 EGFLAM-AS1 EGFLAM-AS2 EGFLAM LINC02110 LOC105374733 ENSG00000250629 |
| GH05G039157 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 11.4 | -84.0 | -83960 | 1.3 | ATF1 ARNT YY1 TCF12 ZNF766 GATA2 FOS JUNB KAT8 ZNF592 | FYB RICTOR DAB2 GOLGA5P1 GC05M039105 |
| GH05G039216 | 1.2 | ENCODE dbSUPER | 15.9 | -144.1 | -144090 | 3.9 | HDGF ATF1 CBX3 PKNOX1 RB1 BRCA1 ZNF2 RAD21 RFX5 YY1 | RICTOR FYB GC05P039191 |
| GH05G039099 | 1.6 | Ensembl ENCODE dbSUPER | 11.4 | -27.6 | -27550 | 4.9 | FOXA2 PKNOX1 MLX ARID4B SIN3A ZNF766 FOS SP5 REST ZNF592 | RICTOR FYB GC05M039105 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around RICTOR on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RICTOR gene promoter:
Regulatory Element Products
Genomic Location for RICTOR Gene
- Chromosome:
- 5
- Start:
- 38,937,919 bp from pter
- End:
- 39,074,419 bp from pter
- Size:
- 136,501 bases
- Orientation:
- Minus strand
Genomic View for RICTOR Gene
Genes around RICTOR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.1 by Ensembl
- 5p13.1 by Entrez Gene
- 5p13.1 by HGNC
RICTOR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RICTOR Gene
Proteins for RICTOR Gene
-
Protein details for RICTOR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6R327-RICTR_HUMAN
- Recommended name:
- Rapamycin-insensitive companion of mTOR
- Protein Accession:
- Q6R327
- B2RNX0
- B7ZMF7
- Q68DT5
- Q86UB7
- Q8N3A0
- Q8NCM6
Protein attributes for RICTOR Gene
- Size:
- 1708 amino acids
- Molecular mass:
- 192218 Da
- Quaternary structure:
-
- Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex (PubMed:15268862, PubMed:17461779, PubMed:17599906). Interacts with CCDC28B (PubMed:23727834). Interacts with NBN (PubMed:23762398). Interacts with PRR5L (PubMed:17461779, PubMed:21964062).
- SequenceCaution:
-
- Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for RICTOR Gene
Post-translational modifications for RICTOR Gene
- Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RICTOR Gene
Antibody Products
- R&D Systems Antibodies for RICTOR (Rictor)
- Cell Signaling Technology (CST) Antibodies for RICTOR (RICTOR)
-
Custom Antibody ServicesOriGene Antibodies for RICTOR
- Novus Biologicals Antibodies for RICTOR
- Invitrogen Antibodies for RICTOR
- antibodies-online Antibodies for RICTOR: See all 139
- GeneTex RICTOR antibody for RICTOR
-
Santa Cruz Biotechnology (SCBT) Antibodies for RICTOR
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RICTOR
- Origene Custom Protein Services for RICTOR
- Search GeneTex for Proteins for RICTOR
Assay Products
- antibodies-online Kits for RICTOR: See all 3
No data available for DME Specific Peptides for RICTOR Gene
Domains & Families for RICTOR Gene
Gene Families for RICTOR Gene
- HGNC:
Protein Domains for RICTOR Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RICTOR Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6R327- Family:
-
- Belongs to the RICTOR family.
Function for RICTOR Gene
Molecular function for RICTOR Gene
- UniProtKB/Swiss-Prot Function:
- Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15467718 |
| GO:0008047 | enzyme activator activity | IBA | -- |
| GO:0019901 | protein kinase binding | IPI | 21177249 |
| GO:0043022 | ribosome binding | IEA | -- |
Phenotypes for RICTOR Gene
- MGI mutant phenotypes for RICTOR:
-
inferred from 8 alleles
- mortality/aging
- cellular phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- neoplasm
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for RICTOR:
-
- Increased vaccinia virus (VACV) infection
- Decreased POU5F1-GFP protein expression
- Decreased shRNA abundance (Z-score < -2)
- Decreased cell migration
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased shRNA abundance (Z-score > 2)
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Increased cell migration
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RICTOR
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RICTOR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
- Search ViGene Biosciences for RICTOR
CRISPR Products
-
OriGene CRISPR knockouts for RICTOR
-
Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
- GenScript: Design CRISPR guide RNA sequences for RICTOR
miRNA for RICTOR Gene
- miRTarBase miRNAs that target RICTOR
-
- hsa-mir-218-5p (MIRT006105)
- hsa-mir-335-5p (MIRT018260)
- hsa-mir-155-5p (MIRT020841)
- hsa-mir-31-3p (MIRT038935)
- hsa-mir-18a-5p (MIRT050668)
- hsa-mir-34a-5p (MIRT054810)
- hsa-mir-6747-5p (MIRT166223)
- hsa-mir-3124-3p (MIRT391490)
- hsa-let-7c-5p (MIRT437348)
- hsa-mir-16-5p (MIRT437349)
- hsa-mir-142-3p (MIRT439769)
- hsa-mir-4665-5p (MIRT469189)
- hsa-mir-1275 (MIRT469190)
- hsa-mir-4472 (MIRT469191)
- hsa-mir-4447 (MIRT469192)
- hsa-mir-6769b-5p (MIRT469193)
- hsa-mir-6769a-5p (MIRT469194)
- hsa-mir-92a-2-5p (MIRT469195)
- hsa-mir-654-5p (MIRT469196)
- hsa-mir-541-3p (MIRT469197)
- hsa-mir-7110-5p (MIRT469198)
- hsa-mir-6842-5p (MIRT469199)
- hsa-mir-6752-5p (MIRT469200)
- hsa-mir-5010-5p (MIRT469201)
- hsa-mir-4525 (MIRT469202)
- hsa-mir-7111-5p (MIRT469203)
- hsa-mir-6870-5p (MIRT469204)
- hsa-mir-4723-5p (MIRT469205)
- hsa-mir-5698 (MIRT469206)
- hsa-mir-6825-5p (MIRT469207)
- hsa-mir-625-5p (MIRT469208)
- hsa-mir-6883-5p (MIRT469209)
- hsa-mir-6785-5p (MIRT469210)
- hsa-mir-4728-5p (MIRT469211)
- hsa-mir-149-3p (MIRT469212)
- hsa-mir-8069 (MIRT469213)
- hsa-mir-8062 (MIRT469214)
- hsa-mir-8079 (MIRT469215)
- hsa-mir-1245a (MIRT469216)
- hsa-mir-6841-5p (MIRT469217)
- hsa-mir-6732-5p (MIRT469218)
- hsa-mir-384 (MIRT654255)
- hsa-mir-3685 (MIRT654256)
- hsa-mir-6509-5p (MIRT654257)
- hsa-mir-202-5p (MIRT654258)
- hsa-mir-337-3p (MIRT654259)
- hsa-mir-3160-5p (MIRT654260)
- hsa-mir-3927-5p (MIRT654261)
- hsa-mir-500b-5p (MIRT654262)
- hsa-mir-362-5p (MIRT654263)
miRNA Products
- Search ViGene Biosciences for RICTOR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
-
ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RICTOR
- VectorBuilder custom plasmid, inducible vectors for RICTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RICTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for RICTOR
-
ViGene Biosciences adenoviral particle packaged cDNA for RICTOR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RICTOR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RICTOR Gene
Localization for RICTOR Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0031932 | TORC2 complex | IDA,IEA | 15268862 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for RICTOR Gene
Pathways & Interactions for RICTOR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | GAB1 signalosome |
.89
|
|
| 3 | CD28 co-stimulation | ||
| 4 | mTOR signaling pathway (KEGG) | ||
| 5 | Constitutive Signaling by AKT1 E17K in Cancer | ||
Pathways by source for RICTOR Gene
1 GeneTex pathway for RICTOR Gene
1 Cell Signaling Technology pathway for RICTOR Gene
10 BioSystems pathways for RICTOR Gene
35 Reactome pathways for RICTOR Gene
1 KEGG pathway for RICTOR Gene
2 R&D Systems pathways for RICTOR Gene
1 Qiagen pathway for RICTOR Gene
Interacting Proteins for RICTOR Gene
Selected Interacting proteins:
ENSP00000349959
Q6R327-RICTR_HUMAN
for RICTOR Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009790 | embryo development | IEA,ISS | -- |
| GO:0010468 | regulation of gene expression | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IGI | 21177249 |
Drugs & Compounds for RICTOR Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| OSI-027 | Pharma | inhibitor | MTORC1/ mTORC2 inhibitor, Kinase Inhibitors | 0 | ||
| AZD2014 | Pharma | Novel mTOR inhibitor | 0 | |||
| GDC-0349 | Pharma | MTOR inhibitor | 0 | |||
| GDC-0980 (RG7422) | Pharma | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 0 | |||
| INK 128 (MLN0128) | Pharma | MTOR(TORC-1/-2) inhibitor,potent and selective | 0 |
(12) ApexBio Compounds for RICTOR Gene
| Compound | Action | Cas Number |
|---|---|---|
| AZD2014 | Novel mTOR inhibitor | 1009298-59-2 |
| GDC-0349 | MTOR inhibitor | 1207360-89-1 |
| GDC-0980 (RG7422) | Class I PI3K inhibitor for PI3Kα/β/δ/γ | 1032754-93-0 |
| INK 128 (MLN0128) | MTOR(TORC-1/-2) inhibitor,potent and selective | 1224844-38-5 |
| KU-0063794 | MTORC1 and mTORC2 inhibitor | 938440-64-3 |
| OSI-027 | MTORC1/ mTORC2 inhibitor | 936890-98-1 |
| Ridaforolimus (Deforolimus, MK-8669) | MTOR inhibitor | 572924-54-0 |
| WAY-600 | MTOR inhibitor | 1062159-35-6 |
| WYE-125132 (WYE-132) | ATP-competitive mTOR inhibitor, highly potent | 1144068-46-1 |
| WYE-354 | MTOR inhibitor,potent,ATP-competitive and cell-permeable | 1062169-56-5 |
| WYE-687 | MTOR inhibitor,ATP-competitive and selective | 1062161-90-3 |
| XL388 | MTOR inhibitor,highly potent and selective | 1251156-08-7 |
Transcripts for RICTOR Gene
mRNA/cDNA for RICTOR Gene
- (11) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (166) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RICTOR Gene
CRISPR Products
-
OriGene CRISPR knockouts for RICTOR
-
Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
- GenScript: Design CRISPR guide RNA sequences for RICTOR
miRNA Products
- Search ViGene Biosciences for RICTOR
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
-
ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for RICTOR
- VectorBuilder custom plasmid, inducible vectors for RICTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RICTOR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for RICTOR Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
This gene is overexpressed in Tlymphocyte (42.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RICTOR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RICTOR Gene:
RICTORSOURCE GeneReport for Unigene cluster for RICTOR Gene:
Hs.407926Evidence on tissue expression from TISSUES for RICTOR Gene
- Nervous system(4.6)
- Liver(4.3)
- Muscle(2.4)
- Heart(2.1)
- Kidney(2.1)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for RICTOR
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RICTOR Gene
Orthologs for RICTOR Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RICTOR 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RICTOR 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | RICTOR 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rictor 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RICTOR 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rictor 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RICTOR 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RICTOR 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | RICTOR 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rictor 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | RICTOR (3 of 3) 35 |
|
OneToMany | |
| rictora 35 |
|
OneToMany | |||
| rictorb 34 35 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | rictor 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | rict-1 35 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TSC11 37 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2872 35 |
|
OneToOne |
- Species where no ortholog for RICTOR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RICTOR Gene
No data available for Paralogs for RICTOR Gene
Variants for RICTOR Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034056 | -- | 38,955,318(+) | GGATA(A/G)GTGAT | intron-variant | |
| rs1000067497 | -- | 39,047,063(+) | ATCTT(-/A)AAAAA | intron-variant | |
| rs1000086489 | -- | 39,000,942(+) | AACAA(A/T)CACAC | intron-variant | |
| rs1000097359 | -- | 39,007,619(+) | AAGAA(A/C)AGGCA | intron-variant | |
| rs1000140204 | -- | 39,053,123(+) | TTTTT(C/T)TCCAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5636n100 | CNV | loss | 25217958 |
| dgv9730n54 | CNV | gain | 21841781 |
| esv1576101 | CNV | insertion | 17803354 |
| esv24079 | CNV | loss | 19812545 |
| esv2730111 | CNV | deletion | 23290073 |
| esv3418125 | CNV | insertion | 20981092 |
| esv3604775 | CNV | gain | 21293372 |
| esv3604776 | CNV | loss | 21293372 |
| esv3604777 | CNV | gain | 21293372 |
| nsv4802 | CNV | insertion | 18451855 |
| nsv4803 | CNV | deletion | 18451855 |
| nsv519072 | CNV | loss | 19592680 |
| nsv528773 | CNV | loss | 19592680 |
| nsv529023 | CNV | loss | 19592680 |
| nsv597860 | CNV | gain | 21841781 |
| nsv597861 | CNV | gain | 21841781 |
| nsv597862 | CNV | gain+loss | 21841781 |
| nsv597863 | CNV | gain | 21841781 |
| nsv597867 | CNV | gain | 21841781 |
| nsv597868 | CNV | loss | 21841781 |
| nsv597869 | CNV | gain | 21841781 |
| nsv597870 | CNV | loss | 21841781 |
| nsv818346 | CNV | loss | 17921354 |
| nsv820160 | CNV | loss | 19587683 |
| nsv950671 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
1.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.84;
93.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for RICTOR Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RICTOR
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RICTOR Gene
Disorders for RICTOR Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bardet-biedl syndrome |
|
|
Search RICTOR in MalaCards
View complete list of genes associated with diseases
Relevant External Links for RICTOR
No data available for UniProtKB/Swiss-Prot and Genatlas for RICTOR Gene
Publications for RICTOR Gene
- mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PMID: 19995915) Julien L.A. … Roux P.P. (Mol. Cell. Biol. 2010) 3 4 22 64
- Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PMID: 15718470) Sarbassov D.D. … Sabatini D.M. (Science 2005) 3 4 22 64
- Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PMID: 23762398) Wang J.Q. … Wu K.J. (PLoS ONE 2013) 3 4 64
- Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. (PMID: 21964062) Holmes B. … Gera J. (Cell. Signal. 2012) 3 4 64
- mTOR complex-2 activates ENaC by phosphorylating SGK1. (PMID: 20338997) Lu M. … Pearce D. (J. Am. Soc. Nephrol. 2010) 3 22 64
Products for RICTOR Gene
- R&D Systems Antibodies for RICTOR (Rictor)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for RICTOR
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RICTOR
- Origene Custom Protein Services for RICTOR
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for RICTOR
- Browse OriGene Inhibitory RNA Products For RICTOR
- OriGene qPCR primer pairs for RICTOR
- OriGene CRISPR knockouts for RICTOR
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RICTOR
- GenScript: Next-day shipping cDNA ORF clone for RICTOR in any vector
- GenScript Custom Purified and Recombinant Proteins Services for RICTOR
- GenScript Custom Assay Services for RICTOR
- GenScript Custom overexpressing Cell Line Services for RICTOR
- GenScript: Design CRISPR guide RNA sequences for RICTOR
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RICTOR
- Cell Signaling Technology (CST) Antibodies for RICTOR (RICTOR)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for RICTOR
- Novus Biologicals proteins and lysates for RICTOR
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for RICTOR
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for RICTOR
- Addgene plasmids for RICTOR
- antibodies-online Antibodies for RICTOR: See all 139
- antibodies-online Kits for RICTOR: See all 3
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex RICTOR antibody for RICTOR
- Search GeneTex for Proteins for RICTOR
- ViGene Biosciences adenoviral particle packaged cDNA for RICTOR gene
- ViGene Biosciences lentiviral particle packaged cDNA for RICTOR gene
- ViGene Biosciences ready-to-package AAV shRNAs for RICTOR gene
- Search ViGene Biosciences for RICTOR
- Santa Cruz Biotechnology (SCBT) Antibodies for RICTOR
- Search Santa Cruz Biotechnology (SCBT) for RICTOR siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RICTOR
- Horizon Cell Lines for RICTOR
- Cyagen custom Knockout/knockin (KOKI) mouse models for RICTOR
- VectorBuilder custom plasmid, inducible vectors for RICTOR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RICTOR
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for RICTOR Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer