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RICTOR Gene

protein-coding   GIFtS: 63
GCID: GC05M038939

RPTOR Independent Companion Of MTOR, Complex 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RPTOR Independent Companion Of MTOR, Complex 21 2     AVO32
pianissimo1 2     PIA2
Rapamycin-Insensitive Companion Of MTOR1 2     TORC2-Specific Protein AVO32
AVO3 Homolog2 3     KIAA19993
hAVO32 3     

External Ids:    HGNC: 286111   Entrez Gene: 2532602   Ensembl: ENSG000001643277   OMIM: 6090225   UniProtKB: Q6R3273   

Export aliases for RICTOR gene to outside databases

Previous GC identifer: GC05M038977


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RICTOR Gene:
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth
factor-derived signals to regulate cell growth (Sarbassov et al., 2004 (PubMed 15268862)).(supplied by OMIM, Mar
2008)

GeneCards Summary for RICTOR Gene:
RICTOR (RPTOR independent companion of MTOR, complex 2) is a protein-coding gene. Diseases associated with RICTOR include foramen magnum meningioma, and syringomyelia. GO annotations related to this gene include ribosome binding.

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to
function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type
guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.
mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the
activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the
phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an
essential role in embryonic growth and development

Gene Wiki entry for RICTOR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RICTOR gene promoter:
         C/EBPbeta   AML1a   FOXF2   HSF1 (long)   GATA-2   Meis-1b   Sox9   HSF1short   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRICTOR promoter sequence
   Search Chromatin IP Primers for RICTOR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RICTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.1

RICTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RICTOR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M038939:  view genomic region     (about GC identifiers)

Start:
38,938,021 bp from pter      End:
39,074,510 bp from pter
Size:
136,490 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327 (See protein sequence)
Recommended Name: Rapamycin-insensitive companion of mTOR  
Size: 1708 amino acids; 192218 Da
Subunit: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR,
MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds
directly to MTOR and PRR5 within the TORC2 complex. Interacts with CCDC28B and NBN. May interact with PRR5L
Sequence caution: Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS;
Secondary accessions: B2RNX0 B7ZMF7 Q68DT5 Q86UB7 Q8N3A0 Q8NCM6
Alternative splicing: 3 isoforms:  Q6R327-1   Q6R327-4   Q6R327-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RICTOR: NX_Q6R327

Explore proteomics data for RICTOR at MOPED

Post-translational modifications: 

  • Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR
    inhibits mTORC2 and AKT1 signaling1
  • Ubiquitination2 at Lys1391
  • Modification sites at PhosphoSitePlus

  • See RICTOR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001272368.1  NP_001272369.1  NP_689969.2  

    ENSEMBL proteins: 
     ENSP00000349959   ENSP00000423019   ENSP00000296782   ENSP00000423162  
    Reactome Protein details: Q6R327

    RICTOR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RICTOR
    GenScript Custom Purified and Recombinant Proteins Services for RICTOR
    Novus Biologicals RICTOR Protein
    Novus Biologicals RICTOR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    RICTOR Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RICTOR
    R&D Systems Antibodies for RICTOR
    Cell Signaling Technology (CST) Antibodies for RICTOR 
    OriGene Antibodies for RICTOR
    OriGene Custom Antibody Services for RICTOR
    Novus Biologicals RICTOR Antibodies
    Abcam antibodies for RICTOR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for RICTOR
    LSBio Antibodies in human, mouse, rat for RICTOR

    RICTOR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RICTOR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RICTOR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028268 Pianissimo_fam
     IPR011989 ARM-like
     IPR028272 RICTOR
     IPR028267 Pianissimo_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6R327

    ProtoNet protein and cluster: Q6R327

    UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327
    Similarity: Belongs to the pianissimo family


    RICTOR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RICTR_HUMAN, Q6R327
    Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
    activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to
    function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type
    guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.
    mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the
    activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the
    phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an
    essential role in embryonic growth and development

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15467718
    GO:0043022ribosome binding IEA--
         
    RICTOR for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RICTOR:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rictor) (see all 16):
     adipose tissue  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  renal/urinary system  reproductive system  skeleton 

    RICTOR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rictortm1.2Mgn for RICTOR

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RICTOR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RICTOR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RICTOR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RICTOR

    miRNA
    Products:
        
    miRTarBase miRNAs that target RICTOR:
    hsa-mir-218-5p (MIRT006105), hsa-mir-31-3p (MIRT038935), hsa-mir-335-5p (MIRT018260), hsa-mir-18a-5p (MIRT050668), hsa-mir-155-5p (MIRT020841)

    Block miRNA regulation of human, mouse, rat RICTOR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RICTOR (see all 137):
    hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidRICTOR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RICTOR
    Predesigned siRNA for gene silencing in human, mouse, rat RICTOR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RICTOR

    Clone
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    OriGene clones in human, mouse for RICTOR (see all 5)
    OriGene ORF clones in mouse, rat for RICTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RICTOR
    Browse ESI BIO Cell Lines and PureStem Progenitors for RICTOR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton2
    extracellular2
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0031932TORC2 complex IDA15268862

    RICTOR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RICTOR About   (see all 18)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PI-3K cascade
    PI3K/AKT activation0.93
    PI3K/AKT Signaling in Cancer0.88
    GAB1 signalosome0.93
    PI3K events in ERBB4 signaling0.88
    Constitutive PI3K/AKT Signaling in Cancer0.88
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    2Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    3CD28 co-stimulation
    CD28 co-stimulation0.66
    Costimulation by the CD28 family0.44
    CD28 dependent PI3K/Akt signaling0.66
    4Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RICTOR
        Akt Signaling Pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RICTOR
        mTOR Pathway

    1 Cell Signaling Technology (CST) Pathway for RICTOR
        Translational Control

    Selected BioSystems Pathways for RICTOR (see all 8)
        TOR signaling
    Oncostatin M Signaling Pathway
    Prostate Cancer
    mTOR signaling pathway
    Class I PI3K signaling events mediated by Akt

    3 Reactome Pathways for RICTOR
        Constitutive PI3K/AKT Signaling in Cancer
    PIP3 activates AKT signaling
    CD28 dependent PI3K/Akt signaling


    1 Kegg Pathway  (Kegg details for RICTOR):
        mTOR signaling pathway


    RICTOR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RICTOR: 
              mTOR Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RICTOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RICTOR (Q6R3271, 2, 3 ENSP000003499594) via UniProtKB, MINT, STRING, and/or I2D (see all 230)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628053, ENSP000002893524I2D: score=4 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=4 STRING: ENSP00000366974
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009790embryo development ISS--
    GO:0030334regulation of cell migration ----

    RICTOR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RICTOR (RICTR)

    1 Novoseek inferred chemical compound relationship for RICTOR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 87.1 19 19934294 (2), 19995915 (2), 19153210 (1), 19641186 (1) (see all 11)



    RICTOR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RICTOR gene (3 alternative transcripts): 
    NM_001285439.1  NM_001285440.1  NM_152756.4  

    Unigene Cluster for RICTOR:

    RPTOR independent companion of MTOR, complex 2
    Hs.407926  [show with all ESTs]
    Unigene Representative Sequence: NM_152756
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357387(uc003jlp.2 uc003jlo.2 uc010ivf.2) ENST00000511516
    ENST00000296782 ENST00000505927 ENST00000503698 ENST00000509567 ENST00000515846
    ENST00000510711(uc003jlq.1) ENST00000513566(uc011cpk.1) ENST00000514735

    miRNA
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    Block miRNA regulation of human, mouse, rat RICTOR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RICTOR (see all 137):
    hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidRICTOR 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RICTOR
    Predesigned siRNA for gene silencing in human, mouse, rat RICTOR
    Clone
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    OriGene clones in human, mouse for RICTOR (see all 5)
    OriGene ORF clones in mouse, rat for RICTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RICTOR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RICTOR
      QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
      QuantiFast Probe-based Assays in human, mouse, rat RICTOR

    Additional mRNA sequence: 

    AB082530.1 AK024327.1 AK094538.1 AK127305.1 AK128358.1 AL834497.1 AY515854.1 BC029608.1 
    BC051729.1 BC137163.1 BC137164.1 BC144509.1 CR749280.1 

    10 DOTS entries:

    DT.309782  DT.40269453  DT.91946497  DT.120872839  DT.101978363  DT.100727433  DT.100821095  DT.100821106 
    DT.101974663  DT.91664725 

    Selected AceView cDNA sequences (see all 166):

    AW189422 BQ024546 AA629107 BX497451 AI278480 AB082530 AI004257 AK094538 
    AJ705834 AW074672 AA825726 CB146809 CB243634 BQ228640 AI925493 AW293064 
    AA355244 AI400550 AI291462 BM784969 AK024327 BE049327 BX497450 AA969170 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RICTOR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTCTTCT
    RICTOR Expression
    About this image


    RICTOR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    RICTOR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RICTOR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407926
        Pathway & Disease-focused RT2 Profiler PCR Array including RICTOR: 
              mTOR Signaling in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RICTOR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RICTOR
    QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
    QuantiFast Probe-based Assays in human, mouse, rat RICTOR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RICTOR gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rictor1 , 5 RPTOR independent companion of MTOR, complex 21, 5 88.46(n)1
    95.49(a)1
      15 (3.25 cM)5
    787571  NM_030168.31  NP_084444.31 
     67083815 
    chicken
    (Gallus gallus)
    Aves RICTOR1 RPTOR independent companion of MTOR, complex 2 80.38(n)
    87.57(a)
      427447  XM_003642978.2  XP_003643026.1 
    lizard
    (Anolis carolinensis)
    Reptilia RICTOR6
    RPTOR independent companion of MTOR, complex 2
    84(a)
    1 ↔ 1
    GL343241.1(7680-69695)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rictor1 RPTOR independent companion of MTOR, complex 2 74.93(n)
    82.82(a)
      100485588  XM_002938193.2  XP_002938239.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rictorb1 rapamycin-insensitive companion of mTOR b 68.63(n)
    76.6(a)
      561835  XM_001921872.2  XP_001921907.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta rictor6
    rapamycin-insensitive companion of Tor
    21(a)
    1 ↔ 1
    X(19146144-19155259)
    worm
    (Caenorhabditis elegans)
    Secernentea rict-16
    Protein RICT-1, isoform a (rict-1) mRNA, complete ...
    17(a)
    1 ↔ 1
    II(13098249-13116801) WBGene00009245
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TSC11(YER093C)4 Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), more   --   5(347612-343320) 856828  NP_011018.1 


    ENSEMBL Gene Tree for RICTOR (if available)
    TreeFam Gene Tree for RICTOR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RICTOR (see all 2825)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864450931,2
    --38937949(+) GCATCA/GGCATT 1 -- ds50010--------
    rs1168986581,2
    F--38938266(+) TACAAT/CATAAA 1 -- ut311Minor allele frequency- C:0.04EA 120
    rs1462746821,2
    C--38938422(+) AAACTA/GGTTTA 1 -- ut310--------
    rs109414131,2
    C,F,H--38938664(+) CAGCTA/GTCCGA 1 -- ut3122Minor allele frequency- G:0.11NA NS EA 2780
    rs1391772581,2
    C--38938736(+) CCTACC/TAGGAA 1 -- ut310--------
    rs1912158621,2
    --38939108(+) AAAGAA/GCATTT 1 -- ut310--------
    rs1833348691,2
    --38939114(+) CATTTC/TCCAAA 1 -- ut310--------
    rs1862185941,2
    --38939121(+) CAAAGA/TAGTTT 1 -- ut310--------
    rs1914836201,2
    C--38939176(+) CAAAAA/CTAACT 1 -- ut310--------
    rs794834771,2
    C,F--38939209(+) ACAATT/CTGGTT 1 -- ut311Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for RICTOR (38938021 - 39074510 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RICTOR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730111CNV Deletion23290073
    esv1576101CNV Insertion17803354
    nsv4802CNV Insertion18451855
    nsv528773CNV Loss19592680
    nsv4803CNV Loss18451855
    esv24079CNV Loss19812545
    nsv818346CNV Loss17921354
    nsv820160CNV Loss19587683
    nsv519072CNV Loss19592680
    nsv529023CNV Loss19592680

    3 Site Specific Mutation Identification with PCR Assays for RICTOR:
    Cosmic IdAA Change
    24249p.M675I
    26588p.T722A
    24248p.S159F
    SeqTarget long-range PCR primers for resequencing RICTOR
    DNA2.0 Custom Variant and Variant Library Synthesis for RICTOR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609022    OMIM disorders: --

    Selected diseases for RICTOR (see all 29):    
    About MalaCards
    foramen magnum meningioma    syringomyelia    arachnoid cysts    arachnoiditis
    brain edema    tuberous sclerosis complex    tuberous sclerosis    cytomegalovirus infection
    meningioma    leiomyosarcoma    hemangioma    meningitis
    oral cancer    diffuse large b-cell lymphoma    b-cell lymphomas    glioblastoma multiforme
    myopathy    parkinson's disease    sarcoma    hypoxia

    1 disease from the University of Copenhagen DISEASES database for RICTOR:
    Foramen magnum meningioma

    RICTOR for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RICTOR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 6.27 1 18089801 (1)

    Genetic Association Database (GAD): RICTOR
    Human Genome Epidemiology (HuGE) Navigator: RICTOR (2 documents)

    Export disorders for RICTOR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RICTOR gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with RICTOR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PubMed id 19995915)1, 2, 9 Julien L.A.... Roux P.P. (Mol. Cell. Biol. 2010)
    2. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)1, 2, 9 Sarbassov D.D.... Sabatini D.M. (Science 2005)
    3. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PubMed id 23762398)1, 2 Wang J.Q....Wu K.J. (PLoS ONE 2013)
    4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    5. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)1, 2 Pearce L.R.... Alessi D.R. (Biochem. J. 2007)
    6. Rictor, a novel binding partner of mTOR, defines a rapamycin- insensitive and raptor-independent pathway that regulates the cytoskeleton. (PubMed id 15268862)1, 2 Sarbassov D.D.... Sabatini D.M. (Curr. Biol. 2004)
    7. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PubMed id 15467718)1, 2 Jacinto E....Hall M.N. (Nat. Cell Biol. 2004)
    8. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2 Ohara O.... Koseki H. (DNA Res. 2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. (PubMed id 18089801)1, 9 Masri J....Gera J. (Cancer Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 253260 HGNC: 28611 AceView: MGC39830 Ensembl:ENSG00000164327 euGenes: HUgn253260
    ECgene: RICTOR Kegg: 253260 H-InvDB: RICTOR

    (According to HUGE)
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    HUGE: KIAA1999

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RICTOR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RICTOR gene:
    Search GeneIP for patents involving RICTOR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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