Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RICTOR Gene

protein-coding   GIFtS: 60
GCID: GC05M038977

RPTOR independent companion of MTOR, complex 2

 Explore 20 diseases affiliated with
RICTOR via our new
 Human Malady Compendium 
Biological research products
for RICTOR
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RPTOR Independent Companion Of MTOR, Complex 21 2     MGC398301
PIA1 2     MAVO31
KIAA19991 3     Pianissimo1
AVO3 Homolog2 3     Rapamycin-Insensitive Companion Of MTOR2
HAVO31     TORC2-Specific Protein AVO32
AVO31     

External Ids:    HGNC: 286111   Entrez Gene: 2532602   Ensembl: ENSG000001643277   OMIM: 6090225   UniProtKB: Q6R3273   

Export aliases for RICTOR gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RICTOR:
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth
factor-derived signals to regulate cell growth (Sarbassov et al., 2004 (PubMed 15268862)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function
upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine
nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a
critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of
AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at
'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic
growth and development

Gene Wiki entry for RICTOR


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RICTOR gene promoter:
         C/EBPbeta   AML1a   FOXF2   HSF1 (long)   GATA-2   Meis-1b   Sox9   HSF1short   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRICTOR promoter sequence
   Search SABiosciences Chromatin IP Primers for RICTOR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RICTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.1

RICTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RICTOR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M038977:  view genomic region     (about GC identifiers)

Start:
38,938,021 bp from pter      End:
39,074,510 bp from pter
Size:
136,490 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327 (See protein sequence)
Recommended Name: Rapamycin-insensitive companion of mTOR  
Size: 1708 amino acids; 192218 Da
Subunit: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1
and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to
MTOR and PRR5 within the TORC2 complex. May interact with PRR5L
Sequence caution: Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS;
Secondary accessions: B2RNX0 B7ZMF7 Q68DT5 Q86UB7 Q8N3A0 Q8NCM6
Alternative splicing: 3 isoforms:  Q6R327-1   Q6R327-4   Q6R327-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RICTOR: NX_Q6R327

Post-translational modifications:

  • Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits
  • mTORC2 and AKT1 signaling1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6R327

  • RICTOR Protein expression data from MOPED and PaxDb:    About this image 
    RICTOR Protein Expression
    REFSEQ proteins: NP_689969.2  
    ENSEMBL proteins: 
     ENSP00000349959   ENSP00000423019   ENSP00000296782   ENSP00000423162  
    Reactome Protein details: Q6R327
    Human Recombinant Protein Products for RICTOR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for RICTOR 
    GenScript Custom Purified and Recombinant Proteins Services for RICTOR
    Novus Biologicals RICTOR Protein
    Novus Biologicals RICTOR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RICTOR

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0031932TORC2 complex IDA15467718

    RICTOR for ontologies           About GeneDecksing



    RICTOR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RICTOR
    R&D Systems Antibodies for RICTOR
    Cell Signaling Technology (CST) Antibodies for RICTOR 
    OriGene Antibodies (see all 2): RICTOR
    OriGene Custom Antibody Services for RICTOR 
    GenScript Custom Superior Antibodies Services for RICTOR
    Novus Biologicals RICTOR Antibodies
    Abcam antibodies for RICTOR 
    Uscn Antibodies for RICTOR
    ThermoFisher Antibody for RICTOR

    Assay Products for RICTOR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RICTOR
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RICTOR


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RICTOR for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6R327

    ProtoNet protein and cluster: Q6R327

    UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327
    Similarity: Belongs to the pianissimo family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RICTR_HUMAN, Q6R327
    Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
    activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function
    upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine
    nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a
    critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of
    AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at
    'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic
    growth and development

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0043022ribosome binding IEA--
         
    RICTOR for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RICTOR:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         15/16 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rictor) (see all 16):
     adipose tissue  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  renal/urinary system  reproductive system  skeleton 

    RICTOR for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Rictortm1.2Mgn for RICTOR
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RICTOR 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: RICTOR
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RICTOR
    8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate RICTOR (see all 137):
    hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidRICTOR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RICTOR
    OriGene shRNA RFP: RICTOR
    OriGene siRNA: RICTOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RICTOR
    Sirion Biotech Custom design and validation of potent shRNA sequences against RICTOR 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RICTOR
    Sirion Biotech Customized adenovirus for overexpression of RICTOR 
    Sirion Biotech Customized adenovirus for potent knockdown of RICTOR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RICTOR (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RICTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RICTOR
    Search LifeMap BioReagents cell lines for RICTOR
    Sirion Biotech Customized stable knockdown cell line services for RICTOR 
    Sirion Biotech Customized inducible knockdown cell line services for RICTOR

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    Signaling by FGFR1.00
    DAP12 signaling0.83
    Downstream signaling of activated FGFR0.92
    Signaling by EGFR in Cancer0.83
    Signaling by FGFR in disease0.91
    DAP12 interactions0.76
    Signaling by ERBB20.89
    Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    PI-3K cascade1.00
    PI3K/AKT activation0.97
    PIP3 activates AKT signaling1.00
    GAB1 signalosome0.96
    PI3K/AKT Signaling in Cancer1.00
    Constitutive PI3K/AKT Signaling in Cancer0.88
    PI3K events in ERBB2 signaling1.00
    Signaling by SCF-KIT0.72
    3Immune System
    Immune System1.00
    Innate Immune System0.46
    Adaptive Immune System0.59
    4CD28 co-stimulation
    CD28 co-stimulation1.00
    Costimulation by the CD28 family0.41
    CD28 dependent PI3K/Akt signaling0.66
    5Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)1.00
    Downstream Signaling Events Of B Cell Receptor (BCR)0.81

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for RICTOR
        Translational Control

    5/7 BioSystems Pathways for RICTOR (see all 7
        TOR signaling
    Oncostatin M Signaling Pathway
    Class I PI3K signaling events mediated by Akt
    CXCR3-mediated signaling events
    mTOR signaling pathway

    5/32        Reactome Pathways for RICTOR (see all 32)
        Costimulation by the CD28 family
    Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF


    1         Kegg Pathway  (Kegg details for RICTOR):
        mTOR signaling pathway


    RICTOR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RICTOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/129 Interacting proteins for RICTOR (Q6R3271, 2, 3 ENSP000003499594) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009790embryo development ISS--
    GO:0030838positive regulation of actin filament polymerization IEA--
    GO:0031295T cell costimulation TAS--

    RICTOR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RICTOR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RICTOR
    1 Novoseek chemical compound relationship for RICTOR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 87.1 19 19934294 (2), 19995915 (2), 19153210 (1), 19641186 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about RICTOR / RICTR 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RICTOR gene: 
    NM_152756.3  

    Unigene Cluster for RICTOR:

    RPTOR independent companion of MTOR, complex 2
    Hs.407926  [show with all ESTs]
    Unigene Representative Sequence: NM_152756
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357387(uc003jlp.2 uc003jlo.2 uc010ivf.2) ENST00000511516
    ENST00000296782 ENST00000505927 ENST00000503698 ENST00000509567 ENST00000515846
    ENST00000510711(uc003jlq.1) ENST00000513566(uc011cpk.1) ENST00000514735


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: RICTOR
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RICTOR
    8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate RICTOR (see all 137):
    hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmidRICTOR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RICTOR
    OriGene shRNA RFP: RICTOR
    OriGene siRNA: RICTOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RICTOR
    Sirion Biotech Custom design and validation of potent shRNA sequences against RICTOR 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RICTOR (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RICTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RICTOR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RICTOR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RICTOR

    Additional cDNA sequence: 

    AB082530.1 AK024327.1 AK094538.1 AK127305.1 AK128358.1 AL834497.1 AY515854.1 BC029608.1 
    BC051729.1 BC137163.1 BC137164.1 BC144509.1 CR749280.1 

    10 DOTS entries:

    DT.309782  DT.40269453  DT.91946497  DT.120872839  DT.101978363  DT.100727433  DT.100821095  DT.100821106 
    DT.101974663  DT.91664725 

    24/166 AceView cDNA sequences (see all 166):

    AW293064 AA355244 CB146809 AW189098 BQ228640 AI400550 BX497450 AI956142 
    AA769047 AI278480 AJ705834 AA327719 AA969170 AA361662 AI291462 AA994533 
    AA825726 BX497451 AK024327 AI753066 AI004257 BE049327 BM784969 AK094538 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RICTOR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTTCTTCT
    RICTOR Expression
    About this image
    See RICTOR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RICTOR

    SOURCE GeneReport for Unigene cluster: Hs.407926
        SABiosciences Expression via Pathway-Focused PCR Array including RICTOR: 

              mTOR Signaling in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RICTOR
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RICTOR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RICTOR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RICTOR gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rictor1 , 5 RPTOR independent companion of MTOR, complex 21, 5 88.46(n)1
    95.49(a)1
      15 (3.25 cM)5
    787571  NM_030168.31  NP_084444.31 
     67083815 
    chicken
    (Gallus gallus)
    Aves RICTOR1 RPTOR independent companion of MTOR, complex 2 80.36(n)
    87.57(a)
      427447  XM_003642978.1  XP_003643026.1 
    lizard
    (Anolis carolinensis)
    Reptilia RICTOR6
    --
    85(a)
    1 ↔ 1
    GL343241.1(7908-69695)
    zebrafish
    (Danio rerio)
    Actinopterygii rictor1 RPTOR independent companion of MTOR, complex 2 68.54(n)
    76.42(a)
      561835  XM_001921872.1  XP_001921907.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rictor1 rapamycin-insensitive companion of Tor 41.9(n)
    32.04(a)
      32919  NM_133143.1  NP_573371.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rict-16
    --
    19(a)
    1 ↔ 1
    II(13098179-13116731)


    ENSEMBL Gene Tree for RICTOR (if available)
    TreeFam Gene Tree for RICTOR (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2344 NCBI SNPs in RICTOR are shown (see all 2344    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864450931,2
    --38937949(+) GCATCA/GGCATT 1 -- ds50010--------
    rs1168986581,2
    F--38938266(+) TACAAT/CATAAA 1 -- ut311Minor allele frequency- C:0.04EA 120
    rs1462746821,2
    --38938422(+) AAACTA/GGTTTA 1 -- ut310--------
    rs109414131,2
    C,F,H--38938664(+) CAGCTA/GTCCGA 1 -- ut3122Minor allele frequency- G:0.11NA NS EA 2780
    rs1391772581,2
    --38938736(+) CCTACC/TAGGAA 1 -- ut310--------
    rs1912158621,2
    --38939108(+) AAAGAA/GCATTT 1 -- ut310--------
    rs1833348691,2
    --38939114(+) CATTTC/TCCAAA 1 -- ut310--------
    rs1862185941,2
    --38939121(+) CAAAGA/TAGTTT 1 -- ut310--------
    rs1914836201,2
    --38939176(+) CAAAAA/CTAACT 1 -- ut310--------
    rs794834771,2
    C,F--38939209(+) ACAATT/CTGGTT 1 -- ut311Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for RICTOR (38938021 - 39074510 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for RICTOR
         4 CNVs: 10110 92991 64187 80886
         3 Indels: 92993 59264 92992

    3 SABiosciences Cancer Mutation PCR Assays for RICTOR:
    Cosmic IdAA Change
    24249p.M675I
    26588p.T722A
    24248p.S159F
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RICTOR
    DNA2.0 Custom Variant and Variant Library Synthesis for RICTOR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RICTOR for disorders           About GeneDecksing

    OMIM gene information: 609022    OMIM disorders: --

    20 diseases for RICTOR:    About MalaCards
    diffuse large b-cell lymphoma    b-cell lymphomas    arachnoid cysts    arachnoiditis
    syringomyelia    cytomegalovirus infection    brain edema    tuberous sclerosis
    hemangioma    parkinson's disease    oral cancer    meningitis
    colon cancer    gastric cancer    myopathy    meningioma
    colorectal cancer    prostate cancer    hypoxia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for RICTOR:
    Foramen magnum meningioma

    1 Novoseek disease relationship for RICTOR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 6.27 1 18089801 (1)

    Human Genome Epidemiology (HuGE) Navigator: RICTOR (2 documents)

    Export disorders for RICTOR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RICTOR gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with RICTOR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. mTORC1-activated S6K1 phosphorylates Rictor on threon ine 1135 and regulates mTORC2 signaling. (PubMed id 19995915)1, 2, 9 Julien L.A....Roux P.P. (2010)
    2. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)1, 2, 9 Sarbassov D.D.... Sabatini D.M. (2005)
    3. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)1, 2 Pearce L.R.... Alessi D.R. (2007)
    4. Rictor, a novel binding partner of mTOR, defines a rapamycin- insensitive and raptor-independent pathway that regulates the cytoskeleton. (PubMed id 15268862)1, 2 Sarbassov D.D.... Sabatini D.M. (2004)
    5. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PubMed id 15467718)1, 2 Jacinto E....Hall M.N. (2004)
    6. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2 Ohara O.... Koseki H. (2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    8. mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. (PubMed id 18089801)1, 9 Masri J....Gera J. (2007)
    9. mTOR complex-2 activates ENaC by phosphorylating SGK1 . (PubMed id 20338997)1, 9 Lu M....Pearce D. (2010)
    10. Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer. (PubMed id 19934294)1, 9 Gulhati P....Evers B.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 253260 HGNC: 28611 AceView: MGC39830 Ensembl:ENSG00000164327 euGenes: HUgn253260
    ECgene: RICTOR Kegg: 253260 H-InvDB: RICTOR

    (According to HUGE)
    About This Section
    HUGE: KIAA1999

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RICTOR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RICTOR gene:
    Search GeneIP for patents involving RICTOR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RICTOR
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for RICTOR (Rictor)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for RICTOR   OriGene shRNA RFP for RICTOR  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RICTOR   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RICTOR  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RICTOR   OriGene 3'-UTR Clone for RICTOR  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RICTOR   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RICTOR  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RICTOR   OriGene Custom Protein Services for RICTOR  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RICTOR
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RICTOR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RICTOR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RICTOR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RICTOR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
     GenScript Custom Purified and Recombinant Proteins Services for RICTOR GenScript cDNA clones with any tag delivered in your preferred vector for RICTOR
     GenScript Custom Assay Services for RICTOR GenScript Custom Superior Antibodies Services for RICTOR
     GenScript Custom overexpressing Cell Line Services for RICTOR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for RICTOR 

     Regulatory tfbs in RICTOR promoter
     Search Chromatin IP Primers for RICTOR
     RT2 qPCR Primer Assay in human, mouse, rat RICTOR
     GNC Network for RICTOR
     SABiosciences PCR Arrays including human, mouse, rat RICTOR
     Search Tocris compounds for RICTOR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RICTOR antibodies
     RICTOR proteins
     RICTOR lysates
     Antibodies for RICTOR
     See all of Abcam's Antibodies, Kits and Proteins for RICTOR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RICTOR Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RICTOR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR
     SwitchGear 3'UTR luciferase reporter plasmids for RICTOR
     SwitchGear Promoter luciferase reporter plasmids for RICTOR
     ThermoFisher Antibody for RICTOR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RICTOR
    Sirion Biotech Customized:
     stable knockdown cell line services for RICTOR
     inducible knockdown cell line services for RICTOR
     design and validation of potent shRNA sequences against RICTOR
     adenovirus for potent knockdown of RICTOR
     adenovirus for overexpression of RICTOR
     stable overexpressing cell line services
     inducible overexpressing cell line services
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RICTOR gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4