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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RICTOR Gene

protein-coding   GIFtS: 61
GCID: GC05M038977

RPTOR Independent Companion Of MTOR, Complex 2
Alzheimer's & Parkinson's Diseases Congress
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Aliases
for RICTOR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
RPTOR Independent Companion Of MTOR, Complex 21 2     PIA2
pianissimo1 2     mAVO32
Rapamycin-Insensitive Companion Of MTOR1 2     TORC2-Specific Protein AVO32
AVO3 Homolog2 3     KIAA19993
hAVO32 3     

External Ids:    HGNC: 286111   Entrez Gene: 2532602   Ensembl: ENSG000001643277   OMIM: 6090225   UniProtKB: Q6R3273   

Export aliases for RICTOR gene to outside databases


Summaries
for RICTOR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RICTOR Gene:
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth
factor-derived signals to regulate cell growth (Sarbassov et al., 2004 (PubMed 15268862)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RICTOR Gene: 
RICTOR (RPTOR independent companion of MTOR, complex 2) is a protein-coding gene. Diseases associated with RICTOR include foramen magnum meningioma, and syringomyelia, and among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include protein binding and ribosome binding.

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function
upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine
nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a
critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of
AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at
'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic
growth and development

Gene Wiki entry for RICTOR Gene


Genomic Views
for RICTOR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RICTOR gene promoter:
         C/EBPbeta   AML1a   FOXF2   HSF1 (long)   GATA-2   Meis-1b   Sox9   HSF1short   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RICTOR promoter sequence
   Search SABiosciences Chromatin IP Primers for RICTOR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RICTOR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.1

RICTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RICTOR gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M038977:  view genomic region     (about GC identifiers)

Start:
 38,938,021 bp from pter      End:
 39,074,510 bp from pter
Size:
 136,490 bases      Orientation:
 minus strand

Proteins
for RICTOR gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327 (See protein sequence)
Recommended Name: Rapamycin-insensitive companion of mTOR  
Size: 1708 amino acids; 192218 Da
Subunit: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1
and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to
MTOR and PRR5 within the TORC2 complex. May interact with PRR5L
Sequence caution: Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS;
Secondary accessions: B2RNX0 B7ZMF7 Q68DT5 Q86UB7 Q8N3A0 Q8NCM6
Alternative splicing: 3 isoforms:  Q6R327-1   Q6R327-4   Q6R327-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RICTOR: NX_Q6R327

Explore proteomics data for RICTOR at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits
    • mTORC2 and AKT1 signaling
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6R327

    • RICTOR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RICTOR Protein Expression
    REFSEQ proteins: NP_689969.2  
    ENSEMBL proteins: 
     ENSP00000349959   ENSP00000423019   ENSP00000296782   ENSP00000423162  
    Reactome Protein details: Q6R327
    Human Recombinant Protein Products for RICTOR: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RICTOR
    GenScript Custom Purified and Recombinant Proteins Services for RICTOR
    Novus Biologicals RICTOR Protein
    Novus Biologicals RICTOR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0031932TORC2 complex IDA15268862

    RICTOR for ontologies           About GeneDecksing



    RICTOR Antibody Products: 
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    R&D Systems Antibodies for RICTOR
    Cell Signaling Technology (CST) Antibodies for RICTOR 
    OriGene Antibodies for RICTOR
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    GenScript Custom Superior Antibodies Services for RICTOR
    Novus Biologicals RICTOR Antibodies
    Abcam antibodies for RICTOR
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for RICTOR
    LSBio Antibodies in human, mouse, rat for RICTOR 

    Assay Products for RICTOR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RICTOR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RICTOR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    Protein Domains /
    Families
    for RICTOR gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6R327

    ProtoNet protein and cluster: Q6R327

    UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327
    Similarity: Belongs to the pianissimo family


    RICTOR for domains           About GeneDecksing


    Function
    for RICTOR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RICTR_HUMAN, Q6R327
    Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
    activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function
    upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine
    nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a
    critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of
    AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at
    'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic
    growth and development

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI15467718
    GO:0043022ribosome binding IEA--
         
    RICTOR for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RICTOR:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         15/16 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Rictor) (see all 16):
     adipose tissue  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  renal/urinary system  reproductive system  skeleton 

    RICTOR for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Rictortm1.2Mgn for RICTOR
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RICTOR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RICTOR

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RICTOR
    8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate RICTOR (see all 137):
    hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmid: RICTOR 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RICTOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RICTOR
    Sirion Biotech Custom design and validation of potent shRNA sequences against RICTOR

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RICTOR
    Sirion Biotech Customized adenovirus for overexpression of RICTOR
                         Customized adenovirus for potent knockdown of RICTOR

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RICTOR (see all 5)
    OriGene ORF clones in mouse, rat for RICTOR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RICTOR
    Search LifeMap BioReagents cell lines for RICTOR
    Sirion Biotech Customized stable knockdown cell line services for RICTOR
                         Customized inducible knockdown cell line services for RICTOR

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR


    Pathways & Interactions
    for RICTOR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RICTOR About   (see all 19)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    		Downstream signaling of activated FGFR0.92
    		Downstream signal transduction0.90
    		Signaling by FGFR0.92
    		Signaling by PDGF0.85
    		Signaling by FGFR in disease0.91
    		Signaling by EGFR0.84
    		DAP12 signaling0.91
    		Signaling by EGFR in Cancer0.83
    2PIP3 activates AKT signaling
    		GAB1 signalosome0.93
    		PI3K events in ERBB2 signaling0.88
    		PI3K/AKT activation0.93
    		PI3K events in ERBB4 signaling0.88
    		PIP3 activates AKT signaling0.88
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI-3K cascade0.88
    		Signaling by SCF-KIT0.72
    3CD28 co-stimulation
    		CD28 co-stimulation0.66
    		Costimulation by the CD28 family0.41
    		CD28 dependent PI3K/Akt signaling0.66
    4Immune System
    		Immune System0.56
    		Innate Immune System0.50
    		Adaptive Immune System0.56
    5Signaling by the B Cell Receptor (BCR)
    		Signaling by the B Cell Receptor (BCR)0.81
    		Downstream Signaling Events Of B Cell Receptor (BCR)0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for RICTOR
        Akt Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for RICTOR
        Translational Control

    5/8 BioSystems Pathways for RICTOR (see all 8)
        TOR signaling
    Oncostatin M Signaling Pathway
    Prostate Cancer
    mTOR signaling pathway
    CXCR3-mediated signaling events

    5/34        Reactome Pathways for RICTOR (see all 34)
        Costimulation by the CD28 family
    Signaling by EGFR in Cancer
    Downstream signal transduction
    Signal Transduction
    Signaling by PDGF


    1         Kegg Pathway  (Kegg details for RICTOR):
        mTOR signaling pathway


    RICTOR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RICTOR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/155 Interacting proteins for RICTOR (Q6R3271, 2, 3 ENSP000003499594) via UniProtKB, MINT, STRING, and/or I2D (see all 155)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009790embryo development ISS--
    GO:0030334regulation of cell migration IEA--
    GO:0030838positive regulation of actin filament polymerization IEA--

    RICTOR for ontologies           About GeneDecksing



    Drugs & Compounds
    for RICTOR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RICTOR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RICTOR (RICTR)

    1 Novoseek inferred chemical compound relationship for RICTOR gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rapamycin 87.1 19 19934294 (2), 19995915 (2), 19153210 (1), 19641186 (1) (see all 11)

    Search CenterWatch for drugs/clinical trials and news about RICTOR / RICTR

    Transcripts
    for RICTOR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RICTOR gene: 
    NM_152756.3  

    Unigene Cluster for RICTOR:

    RPTOR independent companion of MTOR, complex 2
    Hs.407926  [show with all ESTs]
    Unigene Representative Sequence: NM_152756
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357387(uc003jlp.2 uc003jlo.2 uc010ivf.2) ENST00000511516
    ENST00000296782 ENST00000505927 ENST00000503698 ENST00000509567 ENST00000515846
    ENST00000510711(uc003jlq.1) ENST00000513566(uc011cpk.1) ENST00000514735


    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RICTOR
    8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate RICTOR (see all 137):
    hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e
    SwitchGear 3'UTR luciferase reporter plasmid: RICTOR 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RICTOR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RICTOR
    Sirion Biotech Custom design and validation of potent shRNA sequences against RICTOR
    Clone
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    OriGene ORF clones in mouse, rat for RICTOR
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RICTOR

    Additional mRNA sequence: 

    AB082530.1 AK024327.1 AK094538.1 AK127305.1 AK128358.1 AL834497.1 AY515854.1 BC029608.1 
    BC051729.1 BC137163.1 BC137164.1 BC144509.1 CR749280.1 

    10 DOTS entries:

    DT.309782  DT.40269453  DT.91946497  DT.120872839  DT.101978363  DT.100727433  DT.100821095  DT.100821106 
    DT.101974663  DT.91664725 

    24/166 AceView cDNA sequences (see all 166):

    AA629107 AA355244 AI925493 CB243634 AI278480 AA769047 AA969170 AA327719 
    AK024327 AI753066 AK094538 AB082530 AW189422 BX497450 BQ024546 AW150469 
    AW074672 AA994533 AI291462 BE049327 AI874286 AI400550 CB146809 AW293064 

    GeneLoc Exon Structure


    Expression
    for RICTOR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RICTOR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTCTTCT
    RICTOR Expression
    About this image


    See RICTOR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RICTOR

    SOURCE GeneReport for Unigene cluster: Hs.407926
        SABiosciences Expression via Pathway-Focused PCR Array including RICTOR: 
              mTOR Signaling in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RICTOR
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR

    Orthologs
    for RICTOR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RICTOR gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rictor1 , 5 RPTOR independent companion of MTOR, complex 21, 5 88.46(n)1
    95.49(a)1    		   15 (3.25 cM)5
    787571  NM_030168.31  NP_084444.31 
     67083815 
    chicken
    (Gallus gallus)    		 Aves RICTOR1 RPTOR independent companion of MTOR, complex 2 80.36(n)
    87.57(a)    		   427447  XM_003642978.1  XP_003643026.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RICTOR6
    		 RPTOR independent companion of MTOR, complex 2
    		 84(a)
    		 1 ↔ 1
    		 GL343241.1(7680-69695)
    zebrafish
    (Danio rerio)    		 Actinopterygii rictor1 RPTOR independent companion of MTOR, complex 2 68.54(n)
    76.42(a)    		   561835  XM_001921872.1  XP_001921907.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta rictor1 rapamycin-insensitive companion of Tor 41.9(n)
    32.04(a)    		   32919  NM_133143.1  NP_573371.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rict-16
    		 Protein RICT-1, isoform a
    		 19(a)
    		 1 ↔ 1
    		 II(13098249-13116801)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TSC11(YER093C)4 Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), more   --   5(347612-343320) 856828  NP_011018.1 


    ENSEMBL Gene Tree for RICTOR (if available)
    TreeFam Gene Tree for RICTOR (if available)

    Paralogs
    for RICTOR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RICTOR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2825 SNPs in RICTOR are shown (see all 2825)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1864450931,2
    		--38937949(+) GCATCA/GGCATT 1 -- ds50010--------
    rs1168986581,2
    		F--38938266(+) TACAAT/CATAAA 1 -- ut311Minor allele frequency- C:0.04EA 120
    rs1462746821,2
    		C--38938422(+) AAACTA/GGTTTA 1 -- ut310--------
    rs109414131,2
    		C,F,H--38938664(+) CAGCTA/GTCCGA 1 -- ut3122Minor allele frequency- G:0.11NA NS EA 2780
    rs1391772581,2
    		C--38938736(+) CCTACC/TAGGAA 1 -- ut310--------
    rs1912158621,2
    		--38939108(+) AAAGAA/GCATTT 1 -- ut310--------
    rs1833348691,2
    		--38939114(+) CATTTC/TCCAAA 1 -- ut310--------
    rs1862185941,2
    		--38939121(+) CAAAGA/TAGTTT 1 -- ut310--------
    rs1914836201,2
    		C--38939176(+) CAAAAA/CTAACT 1 -- ut310--------
    rs794834771,2
    		C,F--38939209(+) ACAATT/CTGGTT 1 -- ut311Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for RICTOR (38938021 - 39074510 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RICTOR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730111CNV Deletion23290073
    esv1576101CNV Insertion17803354
    nsv4802CNV Insertion18451855
    nsv528773CNV Loss19592680
    nsv4803CNV Loss18451855
    esv24079CNV Loss19812545
    nsv818346CNV Loss17921354
    nsv820160CNV Loss19587683
    nsv519072CNV Loss19592680
    nsv529023CNV Loss19592680

    3 SABiosciences Cancer Mutation PCR Assays for RICTOR:
    Cosmic IdAA Change
    24249p.M675I
    26588p.T722A
    24248p.S159F
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RICTOR
    DNA2.0 Custom Variant and Variant Library Synthesis for RICTOR

    Disorders / Diseases
    for RICTOR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RICTOR for disorders           About GeneDecksing

    OMIM gene information: 609022    OMIM disorders: --

    20/25 diseases for RICTOR (see all 25):    About MalaCards
    foramen magnum meningioma    syringomyelia    arachnoid cysts    arachnoiditis
    tuberous sclerosis complex    brain edema    cytomegalovirus infection    tuberous sclerosis
    hemangioma    meningioma    diffuse large b-cell lymphoma    oral cancer
    meningitis    b-cell lymphomas    myopathy    parkinson's disease
    colon cancer    hypoxia    gastric cancer    sarcoma

    1 disease from the University of Copenhagen DISEASES database for RICTOR:
    Foramen magnum meningioma

    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for RICTOR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 6.27 1 18089801 (1)

    Genetic Association Database (GAD): RICTOR
    Human Genome Epidemiology (HuGE) Navigator: RICTOR (2 documents)

    Export disorders for RICTOR gene to outside databases

    Publications
    for RICTOR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RICTOR gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with RICTOR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. mTORC1-activated S6K1 phosphorylates Rictor on threon ine 1135 and regulates mTORC2 signaling. (PubMed id 19995915)1, 2, 9 Julien L.A....Roux P.P. (2010)
    2. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)1, 2, 9 Sarbassov D.D.... Sabatini D.M. (2005)
    3. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    4. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)1, 2 Pearce L.R.... Alessi D.R. (2007)
    5. Rictor, a novel binding partner of mTOR, defines a rapamycin- insensitive and raptor-independent pathway that regulates the cytoskeleton. (PubMed id 15268862)1, 2 Sarbassov D.D.... Sabatini D.M. (2004)
    6. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PubMed id 15467718)1, 2 Jacinto E....Hall M.N. (2004)
    7. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2 Ohara O.... Koseki H. (2002)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    9. mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. (PubMed id 18089801)1, 9 Masri J....Gera J. (2007)
    10. mTOR complex-2 activates ENaC by phosphorylating SGK1 . (PubMed id 20338997)1, 9 Lu M....Pearce D. (2010)

    External Searches for RICTOR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RICTOR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 253260 HGNC: 28611 AceView: MGC39830 Ensembl:ENSG00000164327 euGenes: HUgn253260
    ECgene: RICTOR Kegg: 253260 H-InvDB: RICTOR

    Other Databases showing RICTOR gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1999

    Specialized Databases showing RICTOR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RICTOR Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RICTOR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RICTOR gene:
    Search GeneIP for patents involving RICTOR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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