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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RICTOR Gene

protein-coding GIFtS: 61
GCID: GC05M038977

RPTOR Independent Companion Of MTOR, Complex 2

Alzheimer's & Parkinson's Diseases Congress

25 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
RPTOR Independent Companion Of MTOR, Complex 2¹ ²		PIA²
pianissimo¹ ²		mAVO3²
Rapamycin-Insensitive Companion Of MTOR¹ ²		TORC2-Specific Protein AVO3²
AVO3 Homolog² ³		KIAA1999³
hAVO3² ³

External Ids:	HGNC: 28611¹	Entrez Gene: 253260²	Ensembl: ENSG00000164327⁷	OMIM: 609022⁵	UniProtKB: Q6R327³

Export aliases for RICTOR gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RICTOR Gene:

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth

factor-derived signals to regulate cell growth (Sarbassov et al., 2004 (PubMed 15268862)).(supplied by OMIM, Mar

2008)

GeneCards Summary for RICTOR Gene:

RICTOR (RPTOR independent companion of MTOR, complex 2) is a protein-coding gene. Diseases associated with RICTOR include foramen magnum meningioma, and syringomyelia, and among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include protein binding and ribosome binding.

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327

Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is

activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to

function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type

guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.

mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the

activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the

phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an

essential role in embryonic growth and development

Gene Wiki entry for RICTOR Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NT_006576.16 NC_018916.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RICTOR gene promoter:
C/EBPbeta AML1a FOXF2 HSF1 (long) GATA-2 Meis-1b Sox9 HSF1short Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RICTOR promoter sequence

Search SABiosciences Chromatin IP Primers for RICTOR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RICTOR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1 Ensembl cytogenetic band: 5p13.1 HGNC cytogenetic band: 5p13.1

RICTOR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RICTOR gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M038977: view genomic region (about GC identifiers)

Start:	38,938,021 bp from pter	End:	39,074,510 bp from pter
Size:	136,490 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327 (See protein sequence)

Recommended Name: Rapamycin-insensitive companion of mTOR

Size: 1708 amino acids; 192218 Da

Subunit: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR,

MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds

directly to MTOR and PRR5 within the TORC2 complex. May interact with PRR5L

Sequence caution: Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS;

Secondary accessions: B2RNX0 B7ZMF7 Q68DT5 Q86UB7 Q8N3A0 Q8NCM6

Alternative splicing: 3 isoforms: Q6R327-1 Q6R327-4 Q6R327-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RICTOR: NX_Q6R327

Explore proteomics data for RICTOR at MOPED

Post-translational modifications:

UniProtKB: Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR

inhibits mTORC2 and AKT1 signaling

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q6R327

RICTOR Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_689969.2

ENSEMBL proteins:

ENSP00000349959 ENSP00000423019 ENSP00000296782 ENSP00000423162

Reactome Protein details: Q6R327
Human Recombinant Protein Products for RICTOR:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals RICTOR Protein Novus Biologicals RICTOR Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0031932	TORC2 complex	IDA	15268862

RICTOR for ontologies About GeneDecksing

RICTOR Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RICTOR
	R&D Systems Antibodies for RICTOR
	Cell Signaling Technology (CST) Antibodies for RICTOR
	OriGene Antibodies for RICTOR OriGene Custom Antibody Services for RICTOR
	GenScript Custom Superior Antibodies Services for RICTOR
	Novus Biologicals RICTOR Antibodies
	Abcam antibodies for RICTOR
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for RICTOR
	LSBio Antibodies in human, mouse, rat for RICTOR

Assay Products for RICTOR:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RICTOR
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RICTOR
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR011989 ARM-like

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q6R327

ProtoNet protein and cluster: Q6R327

UniProtKB/Swiss-Prot: RICTR_HUMAN, Q6R327

Similarity: Belongs to the pianissimo family

RICTOR for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RICTR_HUMAN, Q6R327

Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is

activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to

function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type

guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin.

mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the

activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the

phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an

essential role in embryonic growth and development

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	15467718
GO:0043022	ribosome binding	IEA	--

RICTOR for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for RICTOR:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

15/16 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Rictor) (see all 16):

adipose tissue	cardiovascular system	cellular	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	liver/biliary system
mortality/aging	muscle	renal/urinary system	reproductive system	skeleton

RICTOR for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Rictor^tm1.2Mgn for RICTOR

inGenious Targeting Laboratory - Custom generated mouse model solutions for RICTOR

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RICTOR

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RICTOR

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RICTOR

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RICTOR
		8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate RICTOR (see all 137):
		hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e

		SwitchGear 3'UTR luciferase reporter plasmid: RICTOR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RICTOR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RICTOR

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RICTOR
			Sirion Biotech Customized adenovirus for overexpression of RICTOR

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for RICTOR (see all 5) OriGene ORF clones in mouse, rat for RICTOR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RICTOR
		Search LifeMap BioReagents cell lines for RICTOR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RICTOR About (see all 19)

See pathways by source

SuperPath

Selected contained pathways About (see all per SuperPath)

Signaling by FGFR

Downstream signaling of activated FGFR	0.92	Downstream signal transduction	0.90
Signaling by FGFR	0.92	Signaling by PDGF	0.85
Signaling by FGFR in disease	0.91	Signaling by EGFR	0.84
DAP12 signaling	0.91	Signaling by EGFR in Cancer	0.83

PIP3 activates AKT signaling

GAB1 signalosome	0.93	PI3K events in ERBB2 signaling	0.88
PI3K/AKT activation	0.93	PI3K events in ERBB4 signaling	0.88
PIP3 activates AKT signaling	0.88	Constitutive PI3K/AKT Signaling in Cancer	0.88
PI-3K cascade	0.88	Signaling by SCF-KIT	0.72

CD28 co-stimulation

	CD28 co-stimulation	0.66			Costimulation by the CD28 family	0.41
	CD28 dependent PI3K/Akt signaling	0.66

Immune System

	Immune System	0.56			Innate Immune System	0.50
	Adaptive Immune System	0.56

Signaling by the B Cell Receptor (BCR)

Signaling by the B Cell Receptor (BCR)

0.81

Downstream Signaling Events Of B Cell Receptor (BCR)

0.81

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for RICTOR

Akt Signaling Pathway

1 Cell Signaling Technology (CST) Pathway for RICTOR

Translational Control

5/8 BioSystems Pathways for RICTOR (see all 8)

	TOR signaling
	Oncostatin M Signaling Pathway
	Prostate Cancer
	mTOR signaling pathway
	CXCR3-mediated signaling events

5/34 Reactome Pathways for RICTOR (see all 34)

	Costimulation by the CD28 family
	Signaling by EGFR in Cancer
	Downstream signal transduction
	Signal Transduction
	Signaling by PDGF

1 Kegg Pathway (Kegg details for RICTOR):

mTOR signaling pathway

RICTOR for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RICTOR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/155 Interacting proteins for RICTOR (Q6R327^{1, 2, 3} ENSP00000349959⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 155)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=4
HIST1H4B	P62805³	I2D: score=4
HIST1H4C	P62805³	I2D: score=4
HIST1H4D	P62805³	I2D: score=4
HIST1H4E	P62805³	I2D: score=4

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS	--
GO:0009790	embryo development	ISS	--
GO:0030334	regulation of cell migration	IEA	--
GO:0030838	positive regulation of actin filament polymerization	IEA	--

RICTOR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RICTOR for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RICTOR (RICTR)

1 Novoseek inferred chemical compound relationship for RICTOR gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rapamycin	87.1	19	19934294 (2), 19995915 (2), 19153210 (1), 19641186 (1) (see all 11)

Search CenterWatch for drugs/clinical trials and news about RICTOR / RICTR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RICTOR gene:

NM_152756.3

Unigene Cluster for RICTOR:

RPTOR independent companion of MTOR, complex 2

Hs.407926 [show with all ESTs]

Unigene Representative Sequence: NM_152756

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000357387(uc003jlp.2 uc003jlo.2 uc010ivf.2) ENST00000511516

ENST00000296782 ENST00000505927 ENST00000503698 ENST00000509567 ENST00000515846

ENST00000510711(uc003jlq.1) ENST00000513566(uc011cpk.1) ENST00000514735

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RICTOR
		8/137 QIAGEN miScript miRNA Assays for microRNAs that regulate RICTOR (see all 137):
		hsa-miR-520f hsa-miR-938 hsa-miR-128 hsa-miR-3653 hsa-miR-342-3p hsa-miR-519a hsa-miR-4255 hsa-let-7e

		SwitchGear 3'UTR luciferase reporter plasmid: RICTOR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RICTOR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RICTOR

Clone Products:		OriGene clones in human, mouse for RICTOR (see all 5) OriGene ORF clones in mouse, rat for RICTOR OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RICTOR (NM_152756)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RICTOR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RICTOR

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for RICTOR
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RICTOR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RICTOR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RICTOR

Additional mRNA sequence:

AB082530.1 AK024327.1 AK094538.1 AK127305.1 AK128358.1 AL834497.1 AY515854.1 BC029608.1

BC051729.1 BC137163.1 BC137164.1 BC144509.1 CR749280.1

10 DOTS entries:

DT.309782 DT.40269453 DT.91946497 DT.120872839 DT.101978363 DT.100727433 DT.100821095 DT.100821106

DT.101974663 DT.91664725

24/166 AceView cDNA sequences (see all 166):

AA629107 AA355244 AI925493 CB243634 AI278480 AA769047 AA969170 AA327719

AK024327 AI753066 AK094538 AB082530 AW189422 BX497450 BQ024546 AW150469

AW074672 AA994533 AI291462 BE049327 AI874286 AI400550 CB146809 AW293064

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RICTOR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGTTTCTTCT

About this image

See RICTOR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RICTOR

SOURCE GeneReport for Unigene cluster: Hs.407926

SABiosciences Expression via Pathway-Focused PCR Array including RICTOR:

mTOR Signaling in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for RICTOR
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RICTOR
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RICTOR

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RICTOR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RICTOR gene from 7/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rictor^{1 , 5}	RPTOR independent companion of MTOR, complex 2^{1, 5}	88.46(n)¹ 95.49(a)¹		15 (3.25 cM)⁵ 78757¹ NM_030168.3¹ NP_084444.3¹ 6708381⁵
chicken (Gallus gallus)	Aves	RICTOR¹	RPTOR independent companion of MTOR, complex 2	80.36(n) 87.57(a)		427447 XM_003642978.1 XP_003643026.1
lizard (Anolis carolinensis)	Reptilia	RICTOR⁶	RPTOR independent companion of MTOR, complex 2	84(a)	1 ↔ 1	GL343241.1(7680-69695)
zebrafish (Danio rerio)	Actinopterygii	rictor¹	RPTOR independent companion of MTOR, complex 2	68.54(n) 76.42(a)		561835 XM_001921872.1 XP_001921907.1
fruit fly (Drosophila melanogaster)	Insecta	rictor¹	rapamycin-insensitive companion of Tor	41.9(n) 32.04(a)		32919 NM_133143.1 NP_573371.1
worm (Caenorhabditis elegans)	Secernentea	rict-1⁶	Protein RICT-1, isoform a	19(a)	1 ↔ 1	II(13098249-13116801)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TSC11(YER093C)⁴	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), more	--		5(347612-343320) 856828 NP_011018.1

ENSEMBL Gene Tree for RICTOR (if available)
TreeFam Gene Tree for RICTOR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186445093^1,2		--	38937949(+)	`GCATCA/GGCATT`	1	--	ds500¹		0	--	--	--	--
rs116898658^1,2	F	--	38938266(+)	`TACAAT/CATAAA`	1	--	ut3¹		1		EA	120
rs146274682^1,2	C	--	38938422(+)	`AAACTA/GGTTTA`	1	--	ut3¹		0	--	--	--	--
rs10941413^1,2	C,F,H	--	38938664(+)	`CAGCTA/GTCCGA`	1	--	ut3¹		22		NA NS EA	2780
rs139177258^1,2	C	--	38938736(+)	`CCTACC/TAGGAA`	1	--	ut3¹		0	--	--	--	--
rs191215862^1,2		--	38939108(+)	`AAAGAA/GCATTT`	1	--	ut3¹		0	--	--	--	--
rs183334869^1,2		--	38939114(+)	`CATTTC/TCCAAA`	1	--	ut3¹		0	--	--	--	--
rs186218594^1,2		--	38939121(+)	`CAAAGA/TAGTTT`	1	--	ut3¹		0	--	--	--	--
rs191483620^1,2	C	--	38939176(+)	`CAAAAA/CTAACT`	1	--	ut3¹		0	--	--	--	--
rs79483477^1,2	C,F	--	38939209(+)	`ACAATT/CTGGTT`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for RICTOR (38938021 - 39074510 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for RICTOR: About this table

Variant ID	Type	Subtype	PubMed ID
esv2730111	CNV	Deletion	23290073
esv1576101	CNV	Insertion	17803354
nsv4802	CNV	Insertion	18451855
nsv528773	CNV	Loss	19592680
nsv4803	CNV	Loss	18451855
esv24079	CNV	Loss	19812545
nsv818346	CNV	Loss	17921354
nsv820160	CNV	Loss	19587683
nsv519072	CNV	Loss	19592680
nsv529023	CNV	Loss	19592680

3 SABiosciences Cancer Mutation PCR Assays for RICTOR:

Cosmic Id	AA Change
24249	p.M675I
26588	p.T722A
24248	p.S159F

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RICTOR

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 609022 OMIM disorders: --

20/25 diseases for RICTOR (see all 25): About MalaCards

foramen magnum meningioma syringomyelia arachnoid cysts arachnoiditis

tuberous sclerosis complex brain edema cytomegalovirus infection tuberous sclerosis

hemangioma meningioma diffuse large b-cell lymphoma oral cancer

meningitis b-cell lymphomas myopathy parkinson's disease

colon cancer hypoxia gastric cancer sarcoma

1 disease from the University of Copenhagen DISEASES database for RICTOR:

Foramen magnum meningioma

RICTOR for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

1 Novoseek inferred disease relationship for RICTOR gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	6.27	1	18089801 (1)

Genetic Association Database (GAD): RICTOR
Human Genome Epidemiology (HuGE) Navigator: RICTOR (2 documents)

Export disorders for RICTOR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RICTOR gene, integrated from 9 sources (see all 104):
(articles sorted by number of sources associating them with RICTOR)

Utopia: connect your pdf to the dynamic
world of online information

mTORC1-activated S6K1 phosphorylates Rictor on threon ine 1135 and regulates mTORC2 signaling. (PubMed id 19995915)^{1, 2, 9} Julien L.A....Roux P.P. (2010)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PubMed id 15718470)^{1, 2, 9} Sarbassov D.D.... Sabatini D.M. (2005)
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)^{1, 4} Zhang X....Wu X. (2010)
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PubMed id 17461779)^{1, 2} Pearce L.R.... Alessi D.R. (2007)
Rictor, a novel binding partner of mTOR, defines a rapamycin- insensitive and raptor-independent pathway that regulates the cytoskeleton. (PubMed id 15268862)^{1, 2} Sarbassov D.D.... Sabatini D.M. (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PubMed id 15467718)^{1, 2} Jacinto E....Hall M.N. (2004)
Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)^{1, 2} Ohara O.... Koseki H. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. (PubMed id 18089801)^{1, 9} Masri J....Gera J. (2007)
mTOR complex-2 activates ENaC by phosphorylating SGK1 . (PubMed id 20338997)^{1, 9} Lu M....Pearce D. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 253260	HGNC: 28611	AceView: MGC39830	Ensembl:ENSG00000164327	euGenes: HUgn253260
ECgene: RICTOR	Kegg: 253260	H-InvDB: RICTOR

(According to HUGE)
About This Section

HUGE: KIAA1999

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RICTOR	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RICTOR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RICTOR gene:
Search GeneIP for patents involving RICTOR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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RPTOR Independent Companion Of MTOR, Complex 2

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RPTOR Independent Companion Of MTOR, Complex 2

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