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Aliases for RICTOR Gene

Aliases for RICTOR Gene

  • RPTOR Independent Companion Of MTOR Complex 2 2 3 5
  • Rapamycin-Insensitive Companion Of MTOR 2 3
  • AVO3 Homolog 3 4
  • Pianissimo 2 3
  • HAVO3 3 4
  • RPTOR Independent Companion Of MTOR, Complex 2 2
  • TORC2-Specific Protein AVO3 3
  • KIAA1999 4
  • AVO3 3
  • PIA 3

External Ids for RICTOR Gene

Previous GeneCards Identifiers for RICTOR Gene

  • GC05M038977

Summaries for RICTOR Gene

Entrez Gene Summary for RICTOR Gene

  • RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RICTOR Gene

RICTOR (RPTOR Independent Companion Of MTOR Complex 2) is a Protein Coding gene. Among its related pathways are PI-3K cascade-FGFR3 and p70S6K Signaling. GO annotations related to this gene include binding and ribosome binding.

UniProtKB/Swiss-Prot for RICTOR Gene

  • Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.

Gene Wiki entry for RICTOR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RICTOR Gene

Genomics for RICTOR Gene

Regulatory Elements for RICTOR Gene

Enhancers for RICTOR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RICTOR on UCSC Golden Path with GeneCards custom track

Promoters for RICTOR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RICTOR Gene

Chromosome:
5
Start:
38,937,919 bp from pter
End:
39,074,419 bp from pter
Size:
136,501 bases
Orientation:
Minus strand

Genomic View for RICTOR Gene

Genes around RICTOR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RICTOR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RICTOR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RICTOR Gene

Proteins for RICTOR Gene

  • Protein details for RICTOR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6R327-RICTR_HUMAN
    Recommended name:
    Rapamycin-insensitive companion of mTOR
    Protein Accession:
    Q6R327
    Secondary Accessions:
    • B2RNX0
    • B7ZMF7
    • Q68DT5
    • Q86UB7
    • Q8N3A0
    • Q8NCM6

    Protein attributes for RICTOR Gene

    Size:
    1708 amino acids
    Molecular mass:
    192218 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex. Interacts with CCDC28B and NBN. May interact with PRR5L.
    SequenceCaution:
    • Sequence=CAH18135.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for RICTOR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RICTOR Gene

Post-translational modifications for RICTOR Gene

  • Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RICTOR Gene

No data available for DME Specific Peptides for RICTOR Gene

Domains & Families for RICTOR Gene

Protein Domains for RICTOR Gene

Suggested Antigen Peptide Sequences for RICTOR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6R327

UniProtKB/Swiss-Prot:

RICTR_HUMAN :
  • Belongs to the RICTOR family.
Family:
  • Belongs to the RICTOR family.
genes like me logo Genes that share domains with RICTOR: view

No data available for Gene Families for RICTOR Gene

Function for RICTOR Gene

Molecular function for RICTOR Gene

UniProtKB/Swiss-Prot Function:
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development.

Gene Ontology (GO) - Molecular Function for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 15467718
GO:0008047 enzyme activator activity IBA --
GO:0019901 protein kinase binding IPI 21177249
GO:0043022 ribosome binding IEA --
genes like me logo Genes that share ontologies with RICTOR: view
genes like me logo Genes that share phenotypes with RICTOR: view

Animal Models for RICTOR Gene

MGI Knock Outs for RICTOR:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RICTOR Gene

Localization for RICTOR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RICTOR Gene COMPARTMENTS Subcellular localization image for RICTOR gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 3
cytoskeleton 2
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0031932 TORC2 complex IEA,IDA 15268862
genes like me logo Genes that share ontologies with RICTOR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RICTOR Gene

Pathways & Interactions for RICTOR Gene

SuperPathways for RICTOR Gene

genes like me logo Genes that share pathways with RICTOR: view

Pathways by source for RICTOR Gene

SIGNOR curated interactions for RICTOR Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RICTOR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0009790 embryo development IEA,ISS --
GO:0010468 regulation of gene expression IEA --
GO:0018105 peptidyl-serine phosphorylation IGI 21177249
GO:0030010 establishment of cell polarity IBA --
genes like me logo Genes that share ontologies with RICTOR: view

Drugs & Compounds for RICTOR Gene

(18) Drugs for RICTOR Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
OSI-027 Pharma inhibitor MTORC1/ mTORC2 inhibitor, Kinase Inhibitors 0
AZD2014 Pharma Novel mTOR inhibitor 0
GDC-0349 Pharma MTOR inhibitor 0
GDC-0980 (RG7422) Pharma Class I PI3K inhibitor for PI3Kα/β/δ/γ 0
INK 128 (MLN0128) Pharma MTOR(TORC-1/-2) inhibitor,potent and selective 0

(12) ApexBio Compounds for RICTOR Gene

Compound Action Cas Number
AZD2014 Novel mTOR inhibitor 1009298-59-2
GDC-0349 MTOR inhibitor 1207360-89-1
GDC-0980 (RG7422) Class I PI3K inhibitor for PI3Kα/β/δ/γ 1032754-93-0
INK 128 (MLN0128) MTOR(TORC-1/-2) inhibitor,potent and selective 1224844-38-5
KU-0063794 MTORC1 and mTORC2 inhibitor 938440-64-3
OSI-027 MTORC1/ mTORC2 inhibitor 936890-98-1
Ridaforolimus (Deforolimus, MK-8669) MTOR inhibitor 572924-54-0
WAY-600 MTOR inhibitor 1062159-35-6
WYE-125132 (WYE-132) ATP-competitive mTOR inhibitor, highly potent 1144068-46-1
WYE-354 MTOR inhibitor,potent,ATP-competitive and cell-permeable 1062169-56-5
WYE-687 MTOR inhibitor,ATP-competitive and selective 1062161-90-3
XL388 MTOR inhibitor,highly potent and selective 1251156-08-7
genes like me logo Genes that share compounds with RICTOR: view

Transcripts for RICTOR Gene

Unigene Clusters for RICTOR Gene

RPTOR independent companion of MTOR, complex 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RICTOR Gene

No ASD Table

Relevant External Links for RICTOR Gene

GeneLoc Exon Structure for
RICTOR
ECgene alternative splicing isoforms for
RICTOR

Expression for RICTOR Gene

mRNA expression in normal human tissues for RICTOR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RICTOR Gene

This gene is overexpressed in Tlymphocyte (42.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RICTOR Gene



Protein tissue co-expression partners for RICTOR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RICTOR Gene:

RICTOR

SOURCE GeneReport for Unigene cluster for RICTOR Gene:

Hs.407926
genes like me logo Genes that share expression patterns with RICTOR: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RICTOR Gene

Orthologs for RICTOR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RICTOR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RICTOR 34
  • 94.16 (n)
  • 97.89 (a)
RICTOR 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RICTOR 34
  • 94.45 (n)
  • 98.35 (a)
RICTOR 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rictor 34
  • 88.46 (n)
  • 95.49 (a)
Rictor 16
Rictor 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RICTOR 34
  • 99.46 (n)
  • 99.54 (a)
RICTOR 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rictor 34
  • 89.08 (n)
  • 96.74 (a)
oppossum
(Monodelphis domestica)
Mammalia RICTOR 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RICTOR 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RICTOR 34
  • 80.38 (n)
  • 87.57 (a)
RICTOR 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RICTOR 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rictor 34
  • 74.93 (n)
  • 82.82 (a)
zebrafish
(Danio rerio)
Actinopterygii rictorb 34
  • 68.63 (n)
  • 76.6 (a)
RICTOR (3 of 3) 35
  • 81 (a)
OneToMany
rictora 35
  • 73 (a)
OneToMany
rictorb 35
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta rictor 35
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rict-1 35
  • 17 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSC11 35
  • 18 (a)
OneToOne
TSC11 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2872 35
  • 39 (a)
OneToOne
Species where no ortholog for RICTOR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RICTOR Gene

ENSEMBL:
Gene Tree for RICTOR (if available)
TreeFam:
Gene Tree for RICTOR (if available)

Paralogs for RICTOR Gene

No data available for Paralogs for RICTOR Gene

Variants for RICTOR Gene

Sequence variations from dbSNP and Humsavar for RICTOR Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2043112 - 38,955,694(-) CAACT(A/C/T)CAAAT reference, missense
rs1423688 -- 39,072,514(-) GGAGC(A/C)CTTAA intron-variant
rs4018950 -- 38,994,733(-) GTAGT(-/AGTC/CAGT)NNNTT intron-variant
rs4018951 -- 38,991,542(-) AAGTT(-/AATCAAT)TAATT intron-variant
rs4018991 -- 38,960,750(+) ATCCC(-/CA)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RICTOR Gene

Variant ID Type Subtype PubMed ID
dgv5636n100 CNV loss 25217958
dgv9730n54 CNV gain 21841781
esv1576101 CNV insertion 17803354
esv24079 CNV loss 19812545
esv2730111 CNV deletion 23290073
esv3418125 CNV insertion 20981092
esv3604775 CNV gain 21293372
esv3604776 CNV loss 21293372
esv3604777 CNV gain 21293372
nsv4802 CNV insertion 18451855
nsv4803 CNV deletion 18451855
nsv519072 CNV loss 19592680
nsv528773 CNV loss 19592680
nsv529023 CNV loss 19592680
nsv597860 CNV gain 21841781
nsv597861 CNV gain 21841781
nsv597862 CNV gain+loss 21841781
nsv597863 CNV gain 21841781
nsv597867 CNV gain 21841781
nsv597868 CNV loss 21841781
nsv597869 CNV gain 21841781
nsv597870 CNV loss 21841781
nsv818346 CNV loss 17921354
nsv820160 CNV loss 19587683
nsv950671 CNV duplication 24416366

Variation tolerance for RICTOR Gene

Residual Variation Intolerance Score: 1.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.84; 93.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RICTOR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RICTOR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RICTOR Gene

Disorders for RICTOR Gene

Relevant External Links for RICTOR

Genetic Association Database (GAD)
RICTOR
Human Genome Epidemiology (HuGE) Navigator
RICTOR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RICTOR

No disorders were found for RICTOR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RICTOR Gene

Publications for RICTOR Gene

  1. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. (PMID: 19995915) Julien L.A. … Roux P.P. (Mol. Cell. Biol. 2010) 3 4 22 65
  2. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. (PMID: 15718470) Sarbassov D.D. … Sabatini D.M. (Science 2005) 3 4 22 65
  3. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains. (PMID: 23762398) Wang J.Q. … Wu K.J. (PLoS ONE 2013) 3 4 65
  4. mTOR complex-2 activates ENaC by phosphorylating SGK1. (PMID: 20338997) Lu M. … Pearce D. (J. Am. Soc. Nephrol. 2010) 3 22 65
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X. … Wu X. (Carcinogenesis 2010) 3 46 65

Products for RICTOR Gene

Sources for RICTOR Gene

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