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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RIC8B Gene

protein-coding GIFtS: 45
GCID: GC12P107168

resistance to inhibitors of cholinesterase 8 homolog B (C....

Search for RIC8B
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Resistance To Inhibitors Of Cholinesterase 8 Homolog B (C. Elegans)¹ ²		FLJ10620¹
HSyn¹		Brain Synembryn²
RIC8¹ ²		Synembryn-B¹
Brain Synembrin² ³		Protein Ric-8B³

External Ids:	HGNC: 25555¹	Entrez Gene: 55188²	Ensembl: ENSG00000111785⁷	OMIM: 609147⁵	UniProtKB: Q9NVN3³

Export aliases for RIC8B gene to outside databases

Previous GC identifers: GC12P105671 GC12P104228

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RIC8B_HUMAN, Q9NVN3

Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by

exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha-dependent cAMP accumulation

suggesting that it may be an important component for odorant signal transduction (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RIC8B gene promoter:
NF-1/L NF-1 Pbx1a MAZR HSF1 (long) Lmo2 HNF-3beta C/EBPalpha POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RIC8B promoter sequence

Search SABiosciences Chromatin IP Primers for RIC8B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIC8B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3

RIC8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIC8B gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P107168: view genomic region (about GC identifiers)

Start:	107,168,373 bp from pter	End:	107,283,094 bp from pter
Size:	114,722 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RIC8B_HUMAN, Q9NVN3 (See protein sequence)

Recommended Name: Synembryn-B

Size: 520 amino acids; 58825 Da

Subunit: Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins

when they are in complex with subunits beta and gamma

Subcellular location: Cytoplasm, cell cortex. Note=Localizes to the cell cortex

Sequence caution: Sequence=AAO65923.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Secondary accessions: A2RTZ0 Q4G103 Q6ZRN4 Q86WD3

Alternative splicing: 4 isoforms: Q9NVN3-5 Q9NVN3-1 Q9NVN3-3 Q9NVN3-4 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RIC8B: NX_Q9NVN3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NVN3

RIC8B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060627.2

ENSEMBL proteins:

ENSP00000376582 ENSP00000447801 ENSP00000376583 ENSP00000447701 ENSP00000347662

ENSP00000448743 ENSP00000450396 ENSP00000435301 ENSP00000436359 ENSP00000464118

Human Recombinant Protein Products:

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	Novus Biologicals RIC8B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	--
GO:0005829	cytosol	IDA	12652642
GO:0005886	plasma membrane	IDA	12652642
GO:0005938	cell cortex	IEA	--

RIC8B for ontologies About GeneDecksing

RIC8B Antibody Products:

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Assay Products for RIC8B:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RIC8B for domains About GeneDecksing

4 InterPro domains/families:

IPR019318 Gua_nucleotide_exch_fac_Ric8

IPR011989 ARM-like

IPR008376 Synembryn

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q9NVN3

ProtoNet protein and cluster: Q9NVN3

UniProtKB/Swiss-Prot: RIC8B_HUMAN, Q9NVN3

Similarity: Belongs to the synembryn family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RIC8B_HUMAN, Q9NVN3

Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by

exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha-dependent cAMP accumulation

suggesting that it may be an important component for odorant signal transduction (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: RIC8B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIC8B
		8/89 QIAGEN miScript miRNA Assays for microRNAs that regulate RIC8B (see all 89):
		hsa-miR-124* hsa-miR-140-5p hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-489 hsa-miR-548a-5p hsa-miR-509-3-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RIC8B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIC8B (see all 7) OriGene shRNA RFP: RIC8B OriGene siRNA: RIC8B
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: RIC8B (NM_018157)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIC8B
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RIC8B
		Search LifeMap BioReagents cell lines for RIC8B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8B

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001965	G-protein alpha-subunit binding	IDA	12652642
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--

RIC8B for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RIC8B:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RIC8B

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for RIC8B (Q9NVN3³ ENSP00000376583⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNAQ	P50148³, ENSP00000286548⁴	I2D: score=1 STRING: ENSP00000286548
GNAS	Q5JWF2³, ENSP00000360141⁴	I2D: score=1 STRING: ENSP00000360141

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	IDA	12652642

RIC8B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RIC8B

4 HMDB Compounds for RIC8B About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about RIC8B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RIC8B gene:

NM_018157.2

Unigene Cluster for RIC8B:

Resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)

Hs.131306 [show with all ESTs]

Unigene Representative Sequence: NM_018157

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392837(uc001tlx.3 uc001tly.3 uc001tlz.3 uc009zur.3)

ENST00000550215 ENST00000392839 ENST00000548914 ENST00000355478 ENST00000552619

ENST00000549643 ENST00000462949 ENST00000470628(uc001tlw.3) ENST00000470960

ENST00000546449 ENST00000551756

miRNA Products:		OriGene 3'-UTR Clone: RIC8B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RIC8B
		8/89 QIAGEN miScript miRNA Assays for microRNAs that regulate RIC8B (see all 89):
		hsa-miR-124* hsa-miR-140-5p hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-489 hsa-miR-548a-5p hsa-miR-509-3-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RIC8B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RIC8B (see all 7) OriGene shRNA RFP: RIC8B OriGene siRNA: RIC8B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RIC8B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RIC8B (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RIC8B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RIC8B (NM_018157)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIC8B
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIC8B

Additional cDNA sequence:

BC034220.1 BC132689.1 BC144056.1

11 DOTS entries:

DT.443482 DT.75195965 DT.95162248 DT.40209244 DT.92031435 DT.95162247 DT.102828479 DT.40303001

DT.91653849 DT.121150675 DT.40189305

24/85 AceView cDNA sequences (see all 85):

BC034220 CB528510 AA907903 BX507864 AA488931 BF002825 CB215722 BQ437753

AK128102 AA985627 AK001482 NM_018157 BF445902 AI203211 AA973023 N47506

BM129568 BQ006890 AU129417 CB164304 CB118679 BM793364 BU609025 AI968314

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RIC8B (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	·
SP1:							-				-								-																-		-				-
SP2:							-												-																-		-				-				-		-
SP3:																																			-						-
SP4:											-								-																-		-
SP5:																																			-		-		-		-		-		-		-

ExUns:	17c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RIC8B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RIC8B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See RIC8B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RIC8B

SOURCE GeneReport for Unigene cluster: Hs.131306

SABiosciences Custom PCR Arrays for RIC8B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RIC8B gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ric8b^{1 , 5}	resistance to inhibitors of cholinesterase 8 homolog more^{1, 5}	94.23(n)¹ 96.92(a)¹		10 (41.63 cM)⁵ 237422¹ NM_183172.1¹ NP_898995.1¹ 84917616⁵
chicken (Gallus gallus)	Aves	RIC8B¹	resistance to inhibitors of cholinesterase 8 homolog more	74.57(n) 76.3(a)		418069 XM_416305.3 XP_416305.3
lizard (Anolis carolinensis)	Reptilia	RIC8B⁶	--	71(a)	1 ↔ 1	5(19347900-19376101)
zebrafish (Danio rerio)	Actinopterygii	ric8b¹	resistance to inhibitors of cholinesterase 8 homolog more	57.01(n) 53.54(a)		334503 NM_001005293.1 NP_001005293.1
fruit fly (Drosophila melanogaster)	Insecta	ric8a⁶	ric8a	28(a)	1 → many	X(9150210-9152703)
worm (Caenorhabditis elegans)	Secernentea	ric-8⁶	Synembryn	21(a)	1 → many	IV(2642977-2650102)

ENSEMBL Gene Tree for RIC8B (if available)
TreeFam Gene Tree for RIC8B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RIC8B gene

RIC8A²

1 SIMAP similar gene for RIC8B using alignment to 7 protein entries: RIC8B_HUMAN (see all proteins):

RIC8A

RIC8B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139148797^1,2		--	107166470(+)	`TGGGAA/TCAATA`	2	--	us2k¹ int¹		0	--	--	--	--
rs116620941^1,2	F,	--	107166679(+)	`ATATGC/TTCAAT`	2	--	int¹ us2k¹		1		WA	118
rs144108343^1,2		--	107166727(+)	`ACCAAA/TAGCTC`	2	--	int¹ us2k¹		0	--	--	--	--
rs187263849^1,2		--	107166766(+)	`ATTTCC/TGAATT`	2	--	int¹ us2k¹		0	--	--	--	--
rs189357580^1,2		--	107166803(+)	`CAGCAC/TAGAAG`	2	--	int¹ us2k¹		0	--	--	--	--
rs150553179^1,2		--	107166996(+)	`AGAAAA/GAGCAC`	2	--	int¹ us2k¹		0	--	--	--	--
rs139648426^1,2		--	107167119(+)	`GCTCAC/GTAGAA`	2	--	us2k¹ int¹		0	--	--	--	--
rs149738945^1,2		--	107167185(+)	`TTTAAC/TAGCAC`	2	--	int¹ us2k¹		0	--	--	--	--
rs181513695^1,2		--	107167228(+)	`GAATGA/GATGTG`	2	--	us2k¹ int¹		0	--	--	--	--
rs186042684^1,2		--	107167237(+)	`TGTATG/TAAATT`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RIC8B (107168373 - 107283094 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RIC8B
1 CNV: 30610

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RIC8B

DNA2.0 Custom Variant and Variant Library Synthesis for RIC8B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RIC8B for disorders About MalaCards

RIC8B for disorders About GeneDecksing

OMIM gene information: 609147 OMIM disorders: --

Export disorders for RIC8B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RIC8B gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with RIC8B)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. (PubMed id 12652642)^{1, 2} Klattenhoff C.... Olate J. (2003)
Extensive proteomic screening identifies the obesity- related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression i n early Alzheimer's disease. (PubMed id 20205790)¹ Kajiwara Y....Buxbaum J.D. (2010)
Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination. (PubMed id 20133939)¹ Nagai Y....Itoh H. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. (PubMed id 12509430)¹ Tall G.G....Gilman A.G. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55188	HGNC: 25555	AceView: hSyn	Ensembl:ENSG00000111785	euGenes: HUgn55188
ECgene: RIC8B	H-InvDB: RIC8B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RIC8B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RIC8B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RIC8B gene:
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GeneCards and IP:
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