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Aliases for RIC8B Gene

Aliases for RIC8B Gene

  • RIC8 Guanine Nucleotide Exchange Factor B 2 3 5
  • Brain Synembryn 3 4
  • HSyn 3 4
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog B (C. Elegans) 2
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog B 3
  • Brain Synembrin 3
  • Protein Ric-8B 4
  • Synembryn-B 3
  • RIC8 3

External Ids for RIC8B Gene

Previous GeneCards Identifiers for RIC8B Gene

  • GC12P105671
  • GC12P107168
  • GC12P104228

Summaries for RIC8B Gene

GeneCards Summary for RIC8B Gene

RIC8B (RIC8 Guanine Nucleotide Exchange Factor B) is a Protein Coding gene. GO annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8A.

UniProtKB/Swiss-Prot for RIC8B Gene

  • Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

Additional gene information for RIC8B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC8B Gene

Genomics for RIC8B Gene

Regulatory Elements for RIC8B Gene

Enhancers for RIC8B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H106118 1.5 Ensembl ENCODE dbSUPER 13.6 -650.1 -650145 12 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 FOS ATF7 RIC8B ENSG00000260329 ENSG00000257890 NUAK1 ENSG00000257438
GH12H106073 1.6 Ensembl ENCODE dbSUPER 11.3 -694.6 -694587 12.6 PKNOX1 ARNT FEZF1 ZNF2 YY1 ZNF302 FOS JUNB REST ZNF662 MTERF2 ENSG00000260329 RPL30P12 LOC100287944 RIC8B ENSG00000257890 CKAP4 GC12M106085
GH12H106839 1.1 Ensembl ENCODE 10.7 +66.7 66678 2.5 ELF3 PKNOX1 ARNT FEZF1 RAD21 ZNF143 ZNF654 ELF1 REST ZNF592 RIC8B POLR3B GC12M106848 GC12M106826
GH12H106739 0.8 ENCODE 12 -34.8 -34798 0.2 ATF1 TAL1 JUN ZNF223 FOSL1 HIC1 TCF12 GATA3 CTBP1 NCOR1 RIC8B ENSG00000260329 GC12M106740 ENSG00000257918
GH12H106903 0.9 Ensembl ENCODE 10.2 +129.3 129326 0.8 PKNOX1 TFAP4 MAZ SP3 SP2 IKZF1 PATZ1 KLF9 SP7 TMEM263 ENSG00000260329 POLR3B RIC8B EEF1B2P4 RPL30P12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIC8B on UCSC Golden Path with GeneCards custom track

Promoters for RIC8B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056892 315 2001 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Locations for RIC8B Gene

Genomic Locations for RIC8B Gene
chr12:106,774,285-106,889,316
(GRCh38/hg38)
Size:
115,032 bases
Orientation:
Plus strand
chr12:107,168,373-107,283,094
(GRCh37/hg19)

Genomic View for RIC8B Gene

Genes around RIC8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIC8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIC8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC8B Gene

Proteins for RIC8B Gene

  • Protein details for RIC8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVN3-RIC8B_HUMAN
    Recommended name:
    Synembryn-B
    Protein Accession:
    Q9NVN3
    Secondary Accessions:
    • A2RTZ0
    • Q4G103
    • Q6ZRN4
    • Q86WD3

    Protein attributes for RIC8B Gene

    Size:
    520 amino acids
    Molecular mass:
    58825 Da
    Quaternary structure:
    • Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
    SequenceCaution:
    • Sequence=AAO65923.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC8B Gene

Post-translational modifications for RIC8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIC8B Gene

Domains & Families for RIC8B Gene

Gene Families for RIC8B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RIC8B Gene

Suggested Antigen Peptide Sequences for RIC8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVN3

UniProtKB/Swiss-Prot:

RIC8B_HUMAN :
  • Belongs to the synembryn family.
Family:
  • Belongs to the synembryn family.
genes like me logo Genes that share domains with RIC8B: view

Function for RIC8B Gene

Molecular function for RIC8B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

Phenotypes From GWAS Catalog for RIC8B Gene

Gene Ontology (GO) - Molecular Function for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IDA 12652642
GO:0005085 guanyl-nucleotide exchange factor activity IBA --
GO:0005096 GTPase activator activity IBA --
genes like me logo Genes that share ontologies with RIC8B: view
genes like me logo Genes that share phenotypes with RIC8B: view

Animal Models for RIC8B Gene

MGI Knock Outs for RIC8B:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIC8B Gene

Localization for RIC8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC8B Gene

Cytoplasm, cell cortex. Note=Localizes to the cell cortex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIC8B gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA 12652642
GO:0005886 plasma membrane IDA 12652642
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with RIC8B: view

Pathways & Interactions for RIC8B Gene

SuperPathways for RIC8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IDA 12652642
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RIC8B: view

No data available for Pathways by source and SIGNOR curated interactions for RIC8B Gene

Drugs & Compounds for RIC8B Gene

(4) Drugs for RIC8B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIC8B: view

Transcripts for RIC8B Gene

Unigene Clusters for RIC8B Gene

Resistance to inhibitors of cholinesterase 8 homolog B (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIC8B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8: - - - - - - - - - - - - - - - - - - - -
SP9: - - -

ExUns: 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RIC8B Gene

GeneLoc Exon Structure for
RIC8B
ECgene alternative splicing isoforms for
RIC8B

Expression for RIC8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIC8B Gene

Protein differential expression in normal tissues from HIPED for RIC8B Gene

This gene is overexpressed in Cerebrospinal fluid (57.4) and Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIC8B Gene



Protein tissue co-expression partners for RIC8B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RIC8B Gene:

RIC8B

SOURCE GeneReport for Unigene cluster for RIC8B Gene:

Hs.131306

Evidence on tissue expression from TISSUES for RIC8B Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with RIC8B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIC8B Gene

Orthologs for RIC8B Gene

This gene was present in the common ancestor of animals.

Orthologs for RIC8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIC8B 33 34
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia RIC8B 33 34
  • 96.79 (n)
dog
(Canis familiaris)
Mammalia RIC8B 33 34
  • 96.03 (n)
mouse
(Mus musculus)
Mammalia Ric8b 33 16 34
  • 94.23 (n)
rat
(Rattus norvegicus)
Mammalia Ric8b 33
  • 92.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RIC8B 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RIC8B 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIC8B 33 34
  • 74.45 (n)
lizard
(Anolis carolinensis)
Reptilia RIC8B 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ric8b 33
  • 68.63 (n)
zebrafish
(Danio rerio)
Actinopterygii ric8b 33 34
  • 57.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta ric8a 34
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ric-8 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2446 34
  • 28 (a)
OneToMany
Species where no ortholog for RIC8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC8B Gene

ENSEMBL:
Gene Tree for RIC8B (if available)
TreeFam:
Gene Tree for RIC8B (if available)

Paralogs for RIC8B Gene

Paralogs for RIC8B Gene

(1) SIMAP similar genes for RIC8B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RIC8B: view

Variants for RIC8B Gene

Sequence variations from dbSNP and Humsavar for RIC8B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000023082 -- 106,782,702(+) CTGAT(C/G)ATTTC intron-variant
rs1000030292 -- 106,844,869(+) CTTTC(A/G)GATTA intron-variant
rs1000061514 -- 106,844,460(+) AAAGC(A/G)AGAAG intron-variant
rs1000087574 -- 106,837,459(+) ACTTT(A/G/T)AAAAA intron-variant
rs1000088644 -- 106,776,719(+) ATTGG(C/G)AATGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RIC8B Gene

Variant ID Type Subtype PubMed ID
nsv9005 CNV gain 18304495
nsv560090 CNV gain 21841781

Variation tolerance for RIC8B Gene

Residual Variation Intolerance Score: 32.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIC8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIC8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIC8B Gene

Disorders for RIC8B Gene

Relevant External Links for RIC8B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIC8B

No disorders were found for RIC8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC8B Gene

Publications for RIC8B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. (PMID: 12652642) Klattenhoff C … Olate J (Journal of cellular physiology 2003) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated secretion. (PMID: 26966186) López-Benito S … Arévalo JC (Journal of cell science 2016) 3 60

Products for RIC8B Gene

Sources for RIC8B Gene

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