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Aliases for RIC8B Gene

Aliases for RIC8B Gene

  • RIC8 Guanine Nucleotide Exchange Factor B 2 3
  • Brain Synembryn 3 4
  • HSyn 3 4
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog B (C. Elegans) 2
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog B 3
  • Brain Synembrin 3
  • Protein Ric-8B 4
  • RIC8 3

External Ids for RIC8B Gene

Previous GeneCards Identifiers for RIC8B Gene

  • GC12P105671
  • GC12P107168
  • GC12P104228

Summaries for RIC8B Gene

GeneCards Summary for RIC8B Gene

RIC8B (RIC8 Guanine Nucleotide Exchange Factor B) is a Protein Coding gene. GO annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8A.

UniProtKB/Swiss-Prot for RIC8B Gene

  • Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC8B Gene

Genomics for RIC8B Gene

Regulatory Elements for RIC8B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIC8B Gene

Chromosome:
12
Start:
106,774,285 bp from pter
End:
106,889,316 bp from pter
Size:
115,032 bases
Orientation:
Plus strand

Genomic View for RIC8B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIC8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC8B Gene

Proteins for RIC8B Gene

  • Protein details for RIC8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVN3-RIC8B_HUMAN
    Recommended name:
    Synembryn-B
    Protein Accession:
    Q9NVN3
    Secondary Accessions:
    • A2RTZ0
    • Q4G103
    • Q6ZRN4
    • Q86WD3

    Protein attributes for RIC8B Gene

    Size:
    520 amino acids
    Molecular mass:
    58825 Da
    Quaternary structure:
    • Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
    SequenceCaution:
    • Sequence=AAO65923.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC8B Gene

Proteomics data for RIC8B Gene at MOPED

Post-translational modifications for RIC8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RIC8B Gene

Domains & Families for RIC8B Gene

Protein Domains for RIC8B Gene

Suggested Antigen Peptide Sequences for RIC8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVN3

UniProtKB/Swiss-Prot:

RIC8B_HUMAN :
  • Belongs to the synembryn family.
Family:
  • Belongs to the synembryn family.
genes like me logo Genes that share domains with RIC8B: view

No data available for Gene Families for RIC8B Gene

Function for RIC8B Gene

Molecular function for RIC8B Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

Gene Ontology (GO) - Molecular Function for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IDA 12652642
GO:0005085 guanyl-nucleotide exchange factor activity IBA --
GO:0005096 GTPase activator activity IBA --
GO:0005488 binding --
genes like me logo Genes that share ontologies with RIC8B: view

Phenotypes for RIC8B Gene

genes like me logo Genes that share phenotypes with RIC8B: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIC8B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RIC8B Gene

Localization for RIC8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC8B Gene

Cytoplasm, cell cortex. Note=Localizes to the cell cortex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIC8B Gene COMPARTMENTS Subcellular localization image for RIC8B gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA 12652642
GO:0005886 plasma membrane IDA 12652642
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with RIC8B: view

Pathways & Interactions for RIC8B Gene

SuperPathways for RIC8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IDA 12652642
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RIC8B: view

No data available for Pathways by source and SIGNOR curated interactions for RIC8B Gene

Drugs & Compounds for RIC8B Gene

(4) Drugs for RIC8B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIC8B: view

Transcripts for RIC8B Gene

Unigene Clusters for RIC8B Gene

Resistance to inhibitors of cholinesterase 8 homolog B (C. elegans):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIC8B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIC8B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8: - - - - - - - - - - - - - - - - - - - -
SP9: - - -

ExUns: 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RIC8B Gene

GeneLoc Exon Structure for
RIC8B
ECgene alternative splicing isoforms for
RIC8B

Expression for RIC8B Gene

mRNA expression in normal human tissues for RIC8B Gene

Protein differential expression in normal tissues from HIPED for RIC8B Gene

This gene is overexpressed in Cerebrospinal fluid (57.4) and Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RIC8B Gene



SOURCE GeneReport for Unigene cluster for RIC8B Gene Hs.131306

genes like me logo Genes that share expression patterns with RIC8B: view

Protein tissue co-expression partners for RIC8B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIC8B Gene

Orthologs for RIC8B Gene

This gene was present in the common ancestor of animals.

Orthologs for RIC8B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RIC8B 35
  • 96.79 (n)
  • 98.65 (a)
RIC8B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIC8B 35
  • 96.03 (n)
  • 98.27 (a)
RIC8B 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ric8b 35
  • 94.23 (n)
  • 96.92 (a)
Ric8b 16
Ric8b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RIC8B 35
  • 99.74 (n)
  • 99.81 (a)
RIC8B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ric8b 35
  • 92.69 (n)
  • 95.58 (a)
oppossum
(Monodelphis domestica)
Mammalia RIC8B 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIC8B 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIC8B 35
  • 74.45 (n)
  • 75.83 (a)
RIC8B 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIC8B 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ric8b 35
  • 68.63 (n)
  • 72.06 (a)
zebrafish
(Danio rerio)
Actinopterygii ric8b 35
  • 57.01 (n)
  • 53.75 (a)
ric8b 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ric8a 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ric-8 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2446 36
  • 28 (a)
OneToMany
Species with no ortholog for RIC8B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC8B Gene

ENSEMBL:
Gene Tree for RIC8B (if available)
TreeFam:
Gene Tree for RIC8B (if available)

Paralogs for RIC8B Gene

Paralogs for RIC8B Gene

(1) SIMAP similar genes for RIC8B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RIC8B: view

Variants for RIC8B Gene

Sequence variations from dbSNP and Humsavar for RIC8B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs733891 -- 106,803,724(+) TCAGC(C/G)CATTA intron-variant, upstream-variant-2KB
rs805506 -- 106,888,403(+) ACCTC(A/G)CCTTA utr-variant-3-prime
rs1037013 -- 106,825,530(-) ACTTC(C/T)AGAAA intron-variant
rs1216002 -- 106,819,823(+) ATATT(A/T)TATAC intron-variant
rs1216003 -- 106,796,152(+) gctag(G/T)tctaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIC8B Gene

Variant ID Type Subtype PubMed ID
nsv9005 CNV Gain 18304495
nsv899505 CNV Gain 21882294

Variation tolerance for RIC8B Gene

Residual Variation Intolerance Score: 32.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIC8B Gene

HapMap Linkage Disequilibrium report
RIC8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIC8B Gene

Disorders for RIC8B Gene

Relevant External Links for RIC8B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIC8B
genes like me logo Genes that share disorders with RIC8B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC8B Gene

Publications for RIC8B Gene

  1. RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. (PMID: 10985349) Miller K.G. … Rand J.B. (Neuron 2000) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Genome-wide association study of autistic-like traits in a general population study of young adults. (PMID: 24133439) Jones R.M. … Moses E.K. (Front Hum Neurosci 2013) 67
  4. Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. (PMID: 20205790) Kajiwara Y. … Buxbaum J.D. (Mol Neurodegener 2010) 67
  5. Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination. (PMID: 20133939) Nagai Y. … Itoh H. (J. Biol. Chem. 2010) 67

Products for RIC8B Gene

Sources for RIC8B Gene

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