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Aliases for RIC8B Gene

Aliases for RIC8B Gene

  • RIC8 Guanine Nucleotide Exchange Factor B 2 3
  • Brain Synembryn 3 4
  • HSyn 3 4
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog B (C. Elegans) 2
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog B 3
  • Brain Synembrin 3
  • Protein Ric-8B 4
  • Synembryn-B 3
  • RIC8 3

External Ids for RIC8B Gene

Summaries for RIC8B Gene

GeneCards Summary for RIC8B Gene

RIC8B (RIC8 Guanine Nucleotide Exchange Factor B) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and G-protein alpha-subunit binding. An important paralog of this gene is RIC8A.

UniProtKB/Swiss-Prot for RIC8B Gene

  • Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC8B Gene

Genomics for RIC8B Gene

Genomic Location for RIC8B Gene

Start:
106,774,595 bp from pter
End:
106,889,316 bp from pter
Size:
114,722 bases
Orientation:
Plus strand

Genomic View for RIC8B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIC8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC8B Gene

Regulatory Elements for RIC8B Gene

Proteins for RIC8B Gene

  • Protein details for RIC8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVN3-RIC8B_HUMAN
    Recommended name:
    Synembryn-B
    Protein Accession:
    Q9NVN3
    Secondary Accessions:
    • A2RTZ0
    • Q4G103
    • Q6ZRN4
    • Q86WD3

    Protein attributes for RIC8B Gene

    Size:
    520 amino acids
    Molecular mass:
    58825 Da
    Quaternary structure:
    • Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma.
    SequenceCaution:
    • Sequence=AAO65923.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC8B Gene

Proteomics data for RIC8B Gene at MOPED

Post-translational modifications for RIC8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIC8B Gene

Domains for RIC8B Gene

Protein Domains for RIC8B Gene

UniProtKB/Swiss-Prot:

RIC8B_HUMAN
Family:
  • Belongs to the synembryn family.:
    • Q9NVN3
genes like me logo Genes that share domains with RIC8B: view

No data available for Gene Families for RIC8B Gene

Function for RIC8B Gene

Molecular function for RIC8B Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.

Gene Ontology (GO) - Molecular Function for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IDA 12652642
GO:0005085 guanyl-nucleotide exchange factor activity IBA --
GO:0005096 GTPase activator activity IBA --
GO:0005488 binding --
genes like me logo Genes that share ontologies with RIC8B: view

Phenotypes for RIC8B Gene

GenomeRNAi human phenotypes for RIC8B:
genes like me logo Genes that share phenotypes with RIC8B: view

miRNA for RIC8B Gene

miRTarBase miRNAs that target RIC8B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RIC8B Gene

Localization for RIC8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC8B Gene

Cytoplasm, cell cortex. Note=Localizes to the cell cortex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIC8B Gene COMPARTMENTS Subcellular localization image for RIC8B gene
Compartment Confidence
cytosol 5
plasma membrane 5
cytoskeleton 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA 12652642
GO:0005886 plasma membrane IDA 12652642
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with RIC8B: view

Pathways for RIC8B Gene

SuperPathways for RIC8B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIC8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IDA 12652642
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with RIC8B: view

No data available for Pathways by source for RIC8B Gene

Compounds for RIC8B Gene

(4) HMDB Compounds for RIC8B Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RIC8B: view

Transcripts for RIC8B Gene

Unigene Clusters for RIC8B Gene

Resistance to inhibitors of cholinesterase 8 homolog B (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIC8B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8: - - - - - - - - - - - - - - - - - - - -
SP9: - - -

ExUns: 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RIC8B Gene

GeneLoc Exon Structure for
RIC8B
ECgene alternative splicing isoforms for
RIC8B

Expression for RIC8B Gene

mRNA expression in normal human tissues for RIC8B Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RIC8B Gene

SOURCE GeneReport for Unigene cluster for RIC8B Gene Hs.131306

genes like me logo Genes that share expressions with RIC8B: view

Orthologs for RIC8B Gene

This gene was present in the common ancestor of animals.

Orthologs for RIC8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIC8B 36
  • 99.74 (n)
  • 99.81 (a)
RIC8B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RIC8B 36
  • 96.79 (n)
  • 98.65 (a)
RIC8B 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIC8B 36
  • 96.03 (n)
  • 98.27 (a)
RIC8B 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ric8b 36
  • 94.23 (n)
  • 96.92 (a)
Ric8b 16
Ric8b 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RIC8B 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIC8B 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ric8b 36
  • 92.69 (n)
  • 95.58 (a)
chicken
(Gallus gallus)
Aves RIC8B 36
  • 74.45 (n)
  • 75.83 (a)
RIC8B 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIC8B 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ric8b 36
  • 68.63 (n)
  • 72.06 (a)
zebrafish
(Danio rerio)
Actinopterygii ric8b 36
  • 57.01 (n)
  • 53.75 (a)
ric8b 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ric8a 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ric-8 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2446 37
  • 28 (a)
OneToMany
Species with no ortholog for RIC8B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC8B Gene

ENSEMBL:
Gene Tree for RIC8B (if available)
TreeFam:
Gene Tree for RIC8B (if available)

Paralogs for RIC8B Gene

Paralogs for RIC8B Gene

Selected SIMAP similar genes for RIC8B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RIC8B: view

Variants for RIC8B Gene

Sequence variations from dbSNP and Humsavar for RIC8B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs34747 -- 106,883,035(+) GATGA(A/G)AAAGT intron-variant
rs34748 -- 106,878,670(+) CTTAA(A/G)AAATG intron-variant
rs733891 -- 106,803,724(+) TCAGC(C/G)CATTA intron-variant
rs805503 -- 106,872,502(-) cagta(G/T)agaca intron-variant
rs805504 -- 106,866,858(-) TATGT(A/T)ACCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIC8B Gene

Variant ID Type Subtype PubMed ID
nsv9005 CNV Gain 18304495
nsv899505 CNV Gain 21882294

Relevant External Links for RIC8B Gene

HapMap Linkage Disequilibrium report
RIC8B

Disorders for RIC8B Gene

No disorders were found for RIC8B Gene.

No data available for UniProtKB/Swiss-Prot for RIC8B Gene

Publications for RIC8B Gene

  1. Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. (PMID: 12652642) Klattenhoff C. … Olate J. (J. Cell. Physiol. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for RIC8B Gene

Sources for RIC8B Gene

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