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RIC8B Gene

protein-coding   GIFtS: 47
GCID: GC12P107168

RIC8 Guanine Nucleotide Exchange Factor B

(Previous name: resistance to inhibitors of cholinesterase 8 homolog B (C....)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RIC8 Guanine Nucleotide Exchange Factor B1 2     Brain Synembrin2
Brain Synembryn2 3     Resistance To Inhibitors Of Cholinesterase 8 Homolog B2
hSyn2 3     synembryn-B2
Resistance To Inhibitors Of Cholinesterase 8 Homolog B (C. Elegans)1     Protein Ric-8B3
RIC82     

External Ids:    HGNC: 255551   Entrez Gene: 551882   Ensembl: ENSG000001117857   OMIM: 6091475   UniProtKB: Q9NVN33   

Export aliases for RIC8B gene to outside databases

Previous GC identifers: GC12P105671 GC12P104228


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RIC8B Gene:
RIC8B (RIC8 guanine nucleotide exchange factor B) is a protein-coding gene. GO annotations related to this gene include G-protein alpha-subunit binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8A.

UniProtKB/Swiss-Prot: RIC8B_HUMAN, Q9NVN3
Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by
exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha-dependent cAMP accumulation
suggesting that it may be an important component for odorant signal transduction (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RIC8B gene promoter:
         NF-1/L   NF-1   Pbx1a   MAZR   HSF1 (long)   Lmo2   HNF-3beta   C/EBPalpha   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIC8B promoter sequence
   Search Chromatin IP Primers for RIC8B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIC8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

RIC8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIC8B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P107168:  view genomic region     (about GC identifiers)

Start:
107,168,373 bp from pter      End:
107,283,094 bp from pter
Size:
114,722 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RIC8B_HUMAN, Q9NVN3 (See protein sequence)
Recommended Name: Synembryn-B  
Size: 520 amino acids; 58825 Da
Subunit: Interacts with GDP-bound G alpha proteins GNAI1, GNAL, GNAS and GNAQ. Does not interact with G-alpha
proteins when they are in complex with subunits beta and gamma
Sequence caution: Sequence=AAO65923.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: A2RTZ0 Q4G103 Q6ZRN4 Q86WD3
Alternative splicing: 4 isoforms:  Q9NVN3-5   Q9NVN3-1   Q9NVN3-3   Q9NVN3-4   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RIC8B: NX_Q9NVN3

Explore proteomics data for RIC8B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RIC8B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060627.2  
    ENSEMBL proteins: 
     ENSP00000376582   ENSP00000447801   ENSP00000376583   ENSP00000447701   ENSP00000347662  
     ENSP00000448743   ENSP00000450396   ENSP00000435301   ENSP00000436359   ENSP00000464118  

    RIC8B Human Recombinant Protein Products:

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    OriGene Purified Protein for RIC8B
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    Novus Biologicals RIC8B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RIC8B 

    RIC8B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals RIC8B Antibodies
    Abcam antibodies for RIC8B
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for RIC8B
    LSBio Antibodies in human, mouse, rat for RIC8B

    RIC8B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RIC8B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019318 Gua_nucleotide_exch_fac_Ric8
     IPR011989 ARM-like
     IPR008376 Synembryn
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NVN3

    ProtoNet protein and cluster: Q9NVN3

    UniProtKB/Swiss-Prot: RIC8B_HUMAN, Q9NVN3
    Similarity: Belongs to the synembryn family


    Find genes that share domains with RIC8B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIC8B_HUMAN, Q9NVN3
    Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by
    exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha-dependent cAMP accumulation
    suggesting that it may be an important component for odorant signal transduction (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001965G-protein alpha-subunit binding IDA12652642
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005488binding ----
         
    Find genes that share ontologies with RIC8B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RIC8B:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Ric8b (no phenotypes)

    Find genes that share phenotypes with RIC8B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RIC8B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIC8B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIC8B

    miRNA
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    miRTarBase miRNAs that target RIC8B:
    hsa-mir-215-5p (MIRT024719), hsa-mir-192-5p (MIRT026881)

    Block miRNA regulation of human, mouse, rat RIC8B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RIC8B (see all 89):
    hsa-miR-124* hsa-miR-140-5p hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-489 hsa-miR-548a-5p hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidRIC8B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RIC8B
    Predesigned siRNA for gene silencing in human, mouse, rat RIC8B

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RIC8B

    Clone
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    OriGene clones in human, mouse for RIC8B (see all 7)
    OriGene ORF clones in mouse, rat for RIC8B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIC8B (NM_018157)
    Sino Biological Human cDNA Clone for RIC8B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIC8B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIC8B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RIC8B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RIC8B_HUMAN, Q9NVN3: Cytoplasm, cell cortex. Note=Localizes to the cell cortex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    cytoskeleton4
    nucleus2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol IDA12652642
    GO:0005886plasma membrane IDA12652642
    GO:0005938cell cortex IEA--

    Find genes that share ontologies with RIC8B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RIC8B
    Interactions:

        Search GeneGlobe Interaction Network for RIC8B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RIC8B (Q9NVN33 ENSP000003765834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAQP501483, ENSP000002865484I2D: score=1 STRING: ENSP00000286548
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IDA12652642

    Find genes that share ontologies with RIC8B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RIC8B

    4 HMDB Compounds for RIC8B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RIC8B gene: 
    NM_018157.2  

    Unigene Cluster for RIC8B:

    Resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
    Hs.131306  [show with all ESTs]
    Unigene Representative Sequence: NM_018157
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392837(uc001tlx.3 uc001tly.3 uc001tlz.3 uc009zur.3)
    ENST00000550215 ENST00000392839 ENST00000548914 ENST00000355478 ENST00000552619
    ENST00000549643 ENST00000462949 ENST00000470628(uc001tlw.3) ENST00000470960
    ENST00000546449 ENST00000551756
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RIC8B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RIC8B (see all 89):
    hsa-miR-124* hsa-miR-140-5p hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-489 hsa-miR-548a-5p hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidRIC8B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RIC8B
    Predesigned siRNA for gene silencing in human, mouse, rat RIC8B
    Clone
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    OriGene clones in human, mouse for RIC8B (see all 7)
    OriGene ORF clones in mouse, rat for RIC8B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIC8B (NM_018157)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIC8B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIC8B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RIC8B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIC8B
      QuantiTect SYBR Green Assays in human, mouse, rat RIC8B
      QuantiFast Probe-based Assays in human, mouse, rat RIC8B

    Additional mRNA sequence: 

    BC034220.1 BC132689.1 BC144056.1 

    11 DOTS entries:

    DT.443482  DT.75195965  DT.95162248  DT.40209244  DT.92031435  DT.95162247  DT.102828479  DT.40303001 
    DT.91653849  DT.121150675  DT.40189305 

    Selected AceView cDNA sequences (see all 85):

    CB528510 CB215722 AA907903 AA488931 BM129568 BQ437753 NM_018157 AK128102 
    AA973023 AU129417 BC034220 BF002825 BX507864 CB164304 AA985627 N47506 
    BF445902 BQ006890 AK001482 AI203211 AW013850 BI550042 BF926793 BF103671 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RIC8B (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ·
    SP1:                    -           -                       -                                               -     -           -                                 
    SP2:                    -                                   -                                               -     -           -           -     -               
    SP3:                                                                                                        -                 -                                 
    SP4:                                -                       -                                               -     -                                             
    SP5:                                                                                                        -     -     -     -     -     -     -               

    ExUns: 17c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RIC8B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RIC8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RIC8B Expression
    About this image

    RIC8B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RIC8B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131306
        Custom PCR Arrays for RIC8B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RIC8B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIC8B
    QuantiTect SYBR Green Assays in human, mouse, rat RIC8B
    QuantiFast Probe-based Assays in human, mouse, rat RIC8B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RIC8B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ric8b1 , 5 resistance to inhibitors of cholinesterase 8 homolog more1, 5 94.23(n)1
    96.92(a)1
      10 (41.63 cM)5
    2374221  NM_183172.21  NP_898995.11 
     849176165 
    chicken
    (Gallus gallus)
    Aves RIC8B1 resistance to inhibitors of cholinesterase 8 homolog more 74.45(n)
    75.83(a)
      418069  XM_416305.4  XP_416305.3 
    lizard
    (Anolis carolinensis)
    Reptilia RIC8B6
    RIC8 guanine nucleotide exchange factor B
    68(a)
    1 ↔ 1
    5(19341473-19379245)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ric8b1 resistance to inhibitors of cholinesterase 8 homolog more 68.63(n)
    72.06(a)
      100486010  XM_002942202.2  XP_002942248.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ric8b1 resistance to inhibitors of cholinesterase 8 homolog more 57.01(n)
    53.75(a)
      334503  NM_001005293.1  NP_001005293.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ric8a6
    ric8a
    28(a)
    1 → many
    X(9150210-9152703)
    worm
    (Caenorhabditis elegans)
    Secernentea ric-86
    Protein RIC-8, isoform b (ric-8) mRNA, complete cd...
    21(a)
    1 → many
    IV(2642979-2650104) WBGene00004367


    ENSEMBL Gene Tree for RIC8B (if available)
    TreeFam Gene Tree for RIC8B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RIC8B gene
    RIC8A2  
    1 SIMAP similar gene for RIC8B using alignment to 7 protein entries:     RIC8B_HUMAN (see all proteins):
    RIC8A

    Find genes that share paralogs with RIC8B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RIC8B (see all 1915)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379433791,2
    --107170746(+) TCCCCC/GCCACC 1 -- int10--------
    rs1855031291,2
    --107170934(+) CTGTGC/TCTGGC 1 -- int10--------
    rs1909528771,2
    --107171103(+) TAGTGC/GTTCAG 1 -- int10--------
    rs1835245991,2
    --107171147(+) CAGCTC/TTATGG 1 -- int10--------
    rs1879603541,2
    --107171188(+) AGTTGG/TGTACC 1 -- int10--------
    rs111131131,2
    C,F,H--107171260(+) TTATAG/AGGCAT 1 -- int111Minor allele frequency- A:0.04NS EA NA WA 1486
    rs1917223531,2
    --107171313(+) AGACCA/GGTTCG 1 -- int10--------
    rs1424377701,2
    --107171325(+) TATTTC/GGGAGA 1 -- int10--------
    rs49644881,2
    C,H--107171356(+) GCTACC/TTTATA 1 -- int16Minor allele frequency- T:0.00NS EA NA 420
    rs755971431,2
    F--107171573(+) ATTACA/GTTAAA 1 -- int11Minor allele frequency- G:0.01EA 120

    HapMap Linkage Disequilibrium report for RIC8B (107168373 - 107283094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RIC8B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899505CNV Gain21882294
    nsv9005CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RIC8B
    DNA2.0 Custom Variant and Variant Library Synthesis for RIC8B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609147    OMIM disorders: --


    Find genes that share disorders with RIC8B           About GenesLikeMe


    Export disorders for RIC8B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RIC8B gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with RIC8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol. (PubMed id 12652642)1, 2 Klattenhoff C.... Olate J. (J. Cell. Physiol. 2003)
    4. Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. (PubMed id 20205790)1 Kajiwara Y....Buxbaum J.D. (Mol Neurodegener 2010)
    5. Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination. (PubMed id 20133939)1 Nagai Y....Itoh H. (J. Biol. Chem. 2010)
    6. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PubMed id 19460752)1 Yeung M.L....Jeang K.T. (J. Biol. Chem. 2009)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55188 HGNC: 25555 AceView: hSyn Ensembl:ENSG00000111785 euGenes: HUgn55188
    ECgene: RIC8B H-InvDB: RIC8B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RIC8B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RIC8B gene:
    Search GeneIP for patents involving RIC8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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