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Aliases for RIC8A Gene

Aliases for RIC8A Gene

  • RIC8 Guanine Nucleotide Exchange Factor A 2 3
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog A (C. Elegans) 2
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog A 3
  • Protein Ric-8A 4
  • RIC8 3

External Ids for RIC8A Gene

Previous GeneCards Identifiers for RIC8A Gene

  • GC11P000200
  • GC11P000028

Summaries for RIC8A Gene

GeneCards Summary for RIC8A Gene

RIC8A (RIC8 Guanine Nucleotide Exchange Factor A) is a Protein Coding gene. GO annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8B.

UniProtKB/Swiss-Prot for RIC8A Gene

  • Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Gene Wiki entry for RIC8A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC8A Gene

Genomics for RIC8A Gene

Regulatory Elements for RIC8A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIC8A Gene

Chromosome:
11
Start:
207,511 bp from pter
End:
215,175 bp from pter
Size:
7,665 bases
Orientation:
Plus strand

Genomic View for RIC8A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIC8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC8A Gene

Proteins for RIC8A Gene

  • Protein details for RIC8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPQ8-RIC8A_HUMAN
    Recommended name:
    Synembryn-A
    Protein Accession:
    Q9NPQ8
    Secondary Accessions:
    • Q0P508
    • Q2T9J1
    • Q7Z352
    • Q96EZ1
    • Q96SZ2
    • Q9H064
    • Q9H5H3
    • Q9H9E7

    Protein attributes for RIC8A Gene

    Size:
    531 amino acids
    Molecular mass:
    59710 Da
    Quaternary structure:
    • Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).
    SequenceCaution:
    • Sequence=BAB14282.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14282.1; Type=Frameshift; Positions=397; Evidence={ECO:0000305}; Sequence=BAB15653.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55126.1; Type=Frameshift; Positions=48; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC8A Gene

Proteomics data for RIC8A Gene at MOPED

Post-translational modifications for RIC8A Gene

  • Ubiquitination at Lys 353 and Lys 409
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RIC8A Gene

Domains & Families for RIC8A Gene

Protein Domains for RIC8A Gene

Suggested Antigen Peptide Sequences for RIC8A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPQ8

UniProtKB/Swiss-Prot:

RIC8A_HUMAN :
  • Belongs to the synembryn family.
Family:
  • Belongs to the synembryn family.
genes like me logo Genes that share domains with RIC8A: view

No data available for Gene Families for RIC8A Gene

Function for RIC8A Gene

Molecular function for RIC8A Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Gene Ontology (GO) - Molecular Function for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IBA --
GO:0005085 guanyl-nucleotide exchange factor activity IBA --
GO:0005096 GTPase activator activity IBA --
GO:0005488 binding --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RIC8A: view
genes like me logo Genes that share phenotypes with RIC8A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RIC8A Gene

Localization for RIC8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC8A Gene

Cytoplasm. Cell membrane. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIC8A Gene COMPARTMENTS Subcellular localization image for RIC8A gene
Compartment Confidence
plasma membrane 4
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RIC8A: view

Pathways & Interactions for RIC8A Gene

SuperPathways for RIC8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001944 vasculature development IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
GO:0007369 gastrulation --
genes like me logo Genes that share ontologies with RIC8A: view

No data available for Pathways by source and SIGNOR curated interactions for RIC8A Gene

Drugs & Compounds for RIC8A Gene

(3) Drugs for RIC8A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIC8A: view

Transcripts for RIC8A Gene

Unigene Clusters for RIC8A Gene

Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIC8A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - - - - - - - -
SP6:
SP7: - -
SP8: - - -
SP9: - - - - -
SP10: - - - -
SP11: - -
SP12:

ExUns: 12d · 12e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RIC8A Gene

GeneLoc Exon Structure for
RIC8A
ECgene alternative splicing isoforms for
RIC8A

Expression for RIC8A Gene

mRNA expression in normal human tissues for RIC8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RIC8A Gene

This gene is overexpressed in Bone (43.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for RIC8A Gene



SOURCE GeneReport for Unigene cluster for RIC8A Gene Hs.592292

genes like me logo Genes that share expression patterns with RIC8A: view

Protein tissue co-expression partners for RIC8A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIC8A Gene

Orthologs for RIC8A Gene

This gene was present in the common ancestor of animals.

Orthologs for RIC8A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RIC8A 35
  • 87.67 (n)
  • 90 (a)
RIC8A 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIC8A 35
  • 87.65 (n)
  • 89.6 (a)
RIC8A 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ric8 35
  • 85.47 (n)
  • 88.11 (a)
Ric8 16
Ric8 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RIC8A 35
  • 99.43 (n)
  • 99.25 (a)
RIC8A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ric8a 35
  • 85.09 (n)
  • 87.55 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RIC8A 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIC8A 35
  • 70.98 (n)
  • 69.71 (a)
RIC8A 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIC8A 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76200 35
ric8a 35
  • 62.94 (n)
  • 60.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22237 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11062 35
ric8a 35
  • 61.64 (n)
  • 58.95 (a)
ric8a 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010793 35
  • 50.91 (n)
  • 39.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta ric8a 35
  • 49.35 (n)
  • 38.76 (a)
ric8a 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ric-8 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2446 36
  • 30 (a)
OneToMany
Species with no ortholog for RIC8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC8A Gene

ENSEMBL:
Gene Tree for RIC8A (if available)
TreeFam:
Gene Tree for RIC8A (if available)

Paralogs for RIC8A Gene

Paralogs for RIC8A Gene

(1) SIMAP similar genes for RIC8A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RIC8A: view

Variants for RIC8A Gene

Sequence variations from dbSNP and Humsavar for RIC8A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3216 -- 214,421(-) TTCCC(C/G)AGGTT utr-variant-3-prime
rs1533824 -- 214,169(-) GTCCT(A/G)CTCAC intron-variant
rs1533825 -- 214,163(-) CTCAC(C/T)CGTGG intron-variant
rs1969386 -- 213,772(-) AGAGA(C/T)GGGGT intron-variant
rs2293167 -- 211,644(-) TGTGT(A/C/T)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIC8A Gene

Variant ID Type Subtype PubMed ID
dgv910n71 CNV Gain 21882294
esv22231 CNV Gain 19812545
nsv896436 CNV Gain 21882294
nsv896437 CNV Loss 21882294
dgv911n71 CNV Gain 21882294
nsv467630 CNV Gain 19166990
nsv522596 CNV Gain 19592680
nsv467631 CNV Gain 19166990
nsv896439 CNV Loss 21882294
nsv896440 CNV Gain 21882294
nsv896441 CNV Loss 21882294

Variation tolerance for RIC8A Gene

Residual Variation Intolerance Score: 20.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.55; 95.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIC8A Gene

HapMap Linkage Disequilibrium report
RIC8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIC8A Gene

Disorders for RIC8A Gene

Relevant External Links for RIC8A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIC8A
genes like me logo Genes that share disorders with RIC8A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC8A Gene

Publications for RIC8A Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67
  2. RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. (PMID: 10985349) Miller K.G. … Rand J.B. (Neuron 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on GI+(i3). (PMID: 25480567) Tse M.K. … Wong Y.H. (Mol. Cell. Biochem. 2015) 67

Products for RIC8A Gene

Sources for RIC8A Gene

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