Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RIC8A Gene

protein-coding   GIFtS: 52
GCID: GC11P000207

RIC8 Guanine Nucleotide Exchange Factor A

(Previous name: resistance to inhibitors of cholinesterase 8 homolog A (C....)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RIC8 Guanine Nucleotide Exchange Factor A1 2
Resistance To Inhibitors Of Cholinesterase 8 Homolog A (C. Elegans)1
RIC82
Resistance To Inhibitors Of Cholinesterase 8 Homolog A2
synembryn-A2
Protein Ric-8A3

External Ids:    HGNC: 295501   Entrez Gene: 606262   Ensembl: ENSG000001779637   OMIM: 6091465   UniProtKB: Q9NPQ83   

Export aliases for RIC8A gene to outside databases

Previous GC identifers: GC11P000200 GC11P000028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RIC8A Gene:
RIC8A (RIC8 guanine nucleotide exchange factor A) is a protein-coding gene. Diseases associated with RIC8A include uterine fibroid, and ataxia. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8B.

UniProtKB/Swiss-Prot: RIC8A_HUMAN, Q9NPQ8
Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able
to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of
microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly
leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity).
Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK
activation

Gene Wiki entry for RIC8A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RIC8A gene promoter:
         RFX1   NF-1/L   NF-1   Nkx2-5   Tal-1beta   E47   Roaz   AREB6   Pax-4a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIC8A promoter sequence
   Search Chromatin IP Primers for RIC8A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIC8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

RIC8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIC8A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000207:  view genomic region     (about GC identifiers)

Start:
207,511 bp from pter      End:
215,113 bp from pter
Size:
7,603 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RIC8A_HUMAN, Q9NPQ8 (See protein sequence)
Recommended Name: Synembryn-A  
Size: 531 amino acids; 59710 Da
Subunit: Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does
not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via
C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active
GTP-bound form of GNAI1 (By similarity)
Sequence caution: Sequence=BAB14282.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14282.1; Type=Frameshift; Positions=397; Sequence=BAB15653.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB55126.1; Type=Frameshift; Positions=48;
Secondary accessions: Q0P508 Q2T9J1 Q7Z352 Q96EZ1 Q96SZ2 Q9H064 Q9H5H3 Q9H9E7
Alternative splicing: 4 isoforms:  Q9NPQ8-1   Q9NPQ8-2   Q9NPQ8-3   Q9NPQ8-4   

Explore the universe of human proteins at neXtProt for RIC8A: NX_Q9NPQ8

Explore proteomics data for RIC8A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys353, Lys409
  • Modification sites at PhosphoSitePlus

  • See RIC8A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273063.1  NP_068751.4  

    ENSEMBL proteins: 
     ENSP00000432008   ENSP00000325941   ENSP00000436610   ENSP00000435167   ENSP00000433968  
     ENSP00000434833   ENSP00000433009   ENSP00000436192   ENSP00000434896   ENSP00000431163  

    RIC8A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RIC8A
    OriGene Protein Over-expression Lysate for RIC8A
    OriGene MassSpec for RIC8A
    OriGene Custom Protein Services for RIC8A
    GenScript Custom Purified and Recombinant Proteins Services for RIC8A
    Novus Biologicals RIC8A Protein
    Novus Biologicals RIC8A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    RIC8A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RIC8A
    OriGene Custom Antibody Services for RIC8A
    Novus Biologicals RIC8A Antibodies
    Abcam antibodies for RIC8A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for RIC8A
    LSBio Antibodies in human, mouse, rat for RIC8A

    RIC8A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RIC8A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RIC8A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR019318 Gua_nucleotide_exch_fac_Ric8
     IPR011989 ARM-like
     IPR008376 Synembryn
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NPQ8

    ProtoNet protein and cluster: Q9NPQ8

    UniProtKB/Swiss-Prot: RIC8A_HUMAN, Q9NPQ8
    Similarity: Belongs to the synembryn family


    RIC8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIC8A_HUMAN, Q9NPQ8
    Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able
    to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of
    microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly
    leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity).
    Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK
    activation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI16189514
         
    RIC8A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RIC8A:
     G2 arrest  Increased S DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ric8):
     behavior/neurological  cellular  mortality/aging  nervous system  other 

    RIC8A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RIC8A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RIC8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIC8A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIC8A

    miRNA
    Products:
        
    miRTarBase miRNAs that target RIC8A:
    hsa-mir-92a-3p (MIRT049571)

    Block miRNA regulation of human, mouse, rat RIC8A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RIC8A (see all 12):
    hsa-miR-875-3p hsa-miR-15a hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-497 hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidRIC8A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RIC8A
    Predesigned siRNA for gene silencing in human, mouse, rat RIC8A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RIC8A

    Clone
    Products:
         
    OriGene clones in human, mouse for RIC8A (see all 6)
    OriGene ORF clones in mouse, rat for RIC8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIC8A (NM_021932)
    Sino Biological Human cDNA Clone for RIC8A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIC8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIC8A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RIC8A
    Browse ESI BIO Cell Lines and PureStem Progenitors for RIC8A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RIC8A_HUMAN, Q9NPQ8: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with RIC8A in CA2
    hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane ISS--
    GO:0016020membrane ----

    RIC8A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RIC8A
    Interactions:

        Search GeneGlobe Interaction Network for RIC8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RIC8A (Q9NPQ81, 2, 3 ENSP000003259414) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX01, 2, 3, ENSP000003655764EBI-717509,EBI-741480 MINT-67642 I2D: score=6 STRING: ENSP00000365576
    MAPK8IP3Q9UPT62, 3MINT-65787 I2D: score=5 
    ZNF585BQ52M932, 3MINT-65222 I2D: score=4 
    TUBB2AQ138852, 3MINT-64590 I2D: score=3 
    ENSG00000096150P622693I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001944vasculature development IEA--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
    GO:0007369gastrulation ----
    GO:0008542visual learning IEA--

    RIC8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RIC8A

    3 HMDB Compounds for RIC8A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RIC8A gene (2 alternative transcripts): 
    NM_001286134.1  NM_021932.5  

    Unigene Cluster for RIC8A:

    Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
    Hs.592292  [show with all ESTs]
    Unigene Representative Sequence: AK026897
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526104(uc001log.3) ENST00000325207(uc001lof.3) ENST00000528357
    ENST00000526982 ENST00000532373 ENST00000530889 ENST00000527696(uc001loh.3)
    ENST00000527468 ENST00000527728 ENST00000527039 ENST00000530149 ENST00000532241
    ENST00000524854 ENST00000529275 ENST00000526557 ENST00000531541
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RIC8A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RIC8A (see all 12):
    hsa-miR-875-3p hsa-miR-15a hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-497 hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidRIC8A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RIC8A
    Predesigned siRNA for gene silencing in human, mouse, rat RIC8A
    Clone
    Products:
         
    OriGene clones in human, mouse for RIC8A (see all 6)
    OriGene ORF clones in mouse, rat for RIC8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RIC8A (NM_021932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIC8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIC8A
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RIC8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIC8A
      QuantiTect SYBR Green Assays in human, mouse, rat RIC8A
      QuantiFast Probe-based Assays in human, mouse, rat RIC8A

    Additional mRNA sequence: 

    AK022870.1 AK026897.1 AK027090.1 AK027461.1 AK098267.1 AK225420.1 AK314568.1 AL136935.1 
    AL390088.1 BC011821.1 BC094717.1 BC111499.1 BC121807.1 BC121808.1 BX538115.1 

    Selected DOTS entries (see all 25):

    DT.80101208  DT.100821804  DT.102840703  DT.100821814  DT.95132400  DT.92428394  DT.120712516  DT.101982355 
    DT.120712555  DT.95267637  DT.91960695  DT.102840721  DT.100821812  DT.95267633  DT.120712586  DT.120712635 
    DT.97854912  DT.100821805  DT.100821811  DT.120712561  DT.120712677  DT.95267634  DT.95267635  DT.120712679 

    Selected AceView cDNA sequences (see all 477):

    BM756082 BQ647248 AI538987 BU501910 AA340232 NM_021932 BM915469 AI144493 
    AK027090 CD512808 BM808583 BM010320 BM981522 AI356436 BM558410 AL136935 
    AW440951 BU184537 BG491185 CB114799 BE615039 BU542652 BX350753 AA749181 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RIC8A (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
    SP1:        -     -     -     -                                                     -                                                           -               
    SP2:                                                                                -                                                           -               
    SP3:                                                                                                                                                            
    SP4:                                                                                -                                                                           
    SP5:        -     -     -     -                       -     -     -     -     -     -     -                                                                     

    ExUns: 12d · 12e
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RIC8A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RIC8A expression in normal human tissues (normalized intensities)      RIC8A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGCCTCT
    RIC8A Expression
    About this image


    RIC8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    RIC8A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RIC8A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592292
        Custom PCR Arrays for RIC8A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RIC8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIC8A
    QuantiTect SYBR Green Assays in human, mouse, rat RIC8A
    QuantiFast Probe-based Assays in human, mouse, rat RIC8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RIC8A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ric81 , 5 resistance to inhibitors of cholinesterase 8 homolog more1, 5 85.47(n)1
    88.11(a)1
      7 (86.06 cM)5
    1014891  NM_053194.41  NP_444424.11 
     1408569575 
    chicken
    (Gallus gallus)
    Aves RIC8A1 resistance to inhibitors of cholinesterase 8 homolog more 70.98(n)
    69.71(a)
      422987  NM_001031174.1  NP_001026345.1 
    lizard
    (Anolis carolinensis)
    Reptilia RIC8A6
    RIC8 guanine nucleotide exchange factor A
    66(a)
    1 ↔ 1
    1(77195334-77229580)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.222372 Xenopus laevis transcribed sequence with moderate similarity more 76.94(n)    48027955 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.110622 Transcribed sequence with weak similarity to protein more 74.73(n)    BG307071.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ric8a1 ric8a 49.35(n)
    38.76(a)
      31874  NM_132322.3  NP_572550.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ric-86
    Protein RIC-8, isoform b (ric-8) mRNA, complete cd...
    25(a)
    1 → many
    IV(2642979-2650104) WBGene00004367


    ENSEMBL Gene Tree for RIC8A (if available)
    TreeFam Gene Tree for RIC8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RIC8A gene
    RIC8B2  
    1 SIMAP similar gene for RIC8A using alignment to 8 protein entries:     RIC8A_HUMAN (see all proteins):
    RIC8B

    RIC8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RIC8A (see all 182)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617393861,2
    C,F--209425(+) TGCTGG/CTCTCC 2 /L /V mis14Minor allele frequency- C:0.00NS WA NA 4974
    rs1471115321,2
    C,F--209695(+) GCCTAG/CTGGTG 2 /L /V mis11Minor allele frequency- C:0.00NA 4536
    rs1995777761,2
    --209718(+) CGTGTA/GGGGCT 2 V syn10--------
    rs1165775961,2
    --209820(+) CAGCTG/ATTTCA 2 /L syn11Minor allele frequency- A:0.01NA 214
    rs2016330361,2
    --209894(+) AGGGA-/ACCCCCCA 1 T cds10--------
    rs38327971,2
    C--209895(-) TGGGT-/GGGGGGTT 1 -- cds11Minor allele frequency- GGG:0.00CSA 2
    rs2000409451,2
    --209899(+) ACCCC-/CCACCCAC 1 -- cds10--------
    rs2020160841,2
    --209908(+) CCACGA/CTCCTT 2 I L mis10--------
    rs2017118331,2
    C--209938(+) GGGCCA/GTGGAG 2 M V mis11Minor allele frequency- G:0.00EU 1233
    rs2009362401,2
    --209955(+) AAAGTA/GCTCTT 2 V syn10--------

    HapMap Linkage Disequilibrium report for RIC8A (207511 - 215113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RIC8A (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv896437CNV Loss21882294
    nsv896441CNV Loss21882294
    nsv896439CNV Loss21882294
    nsv467630CNV Gain19166990
    nsv896440CNV Gain21882294
    nsv467631CNV Gain19166990
    nsv522596CNV Gain19592680
    esv22231CNV Gain19812545
    nsv896436CNV Gain21882294
    dgv911n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RIC8A
    DNA2.0 Custom Variant and Variant Library Synthesis for RIC8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609146    OMIM disorders: --

    5 diseases for RIC8A:    About MalaCards
    uterine fibroid    ataxia    malaria    cervicitis
    neuronitis


    RIC8A for disorders           About GeneDecksing


    Export disorders for RIC8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RIC8A gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with RIC8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. (PubMed id 16629901)1, 2 Nishimura A....Itoh H. (Genes Cells 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. (PubMed id 10985349)1, 3 Miller K.G....Rand J.B. (Neuron 2000)
    6. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PubMed id 24026423)1 Shameer K....Kullo I.J. (Hum. Genet. 2014)
    7. Ubiquitination of the heterotrimeric G protein I+ subunits GI+i2 and GI+q is prevented by the guanine nucleotide exchange factor Ric-8A. (PubMed id 23665327)1 Chishiki K....Sumimoto H. (Biochem. Biophys. Res. Commun. 2013)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. NCAM180 regulates Ric8A membrane localization and potentiates I^-adrenergic response. (PubMed id 22384181)1 Amoureux M.C....Rougon G. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 60626 HGNC: 29550 AceView: RIC-8 Ensembl:ENSG00000177963 euGenes: HUgn60626
    ECgene: RIC8A H-InvDB: RIC8A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RIC8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RIC8A gene:
    Search GeneIP for patents involving RIC8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RIC8A   OriGene RNAi products in human, mouse, rat for RIC8A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RIC8A  
     OriGene MassSpec something-or-other for RIC8A   OriGene clones in human, mouse for RIC8A  
     OriGene qSTAR qPCR primer pairs in human, mouse for RIC8A   OriGene Purified Protein for RIC8A  
     OriGene ORF clones in mouse, rat for RIC8A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RIC8A   OriGene Custom Protein Services for RIC8A  

     
     
     Block miRNA regulation of human, mouse, rat RIC8A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RIC8A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RIC8A Predesigned siRNA for gene silencing in human, mouse, rat RIC8A
     QuantiFast Probe-based Assays in human, mouse, rat RIC8A QuantiTect SYBR Green Assays in human, mouse, rat RIC8A
     Custom PCR Arrays for RIC8A Search Chromatin IP Primers for RIC8A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RIC8A  Search GeneGlobe Interaction Network for RIC8A
     Regulatory tfbs in RIC8A promoter
     GenScript Custom Purified and Recombinant Proteins Services for RIC8A GenScript cDNA clones with any tag delivered in your preferred vector for RIC8A
     GenScript Custom Assay Services for RIC8A GenScript Custom overexpressing Cell Line Services for RIC8A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RIC8A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RIC8A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RIC8A antibodies
     RIC8A proteins
     RIC8A lysates
     Antibodies for RIC8A
     See all of Abcam's Antibodies, Kits and Proteins for RIC8A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for RIC8A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8A
     SwitchGear 3'UTR luciferase reporter plasmids for RIC8A
     SwitchGear Promoter luciferase reporter plasmids for RIC8A
     ThermoFisher Antibodies for RIC8A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIC8A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RIC8A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RIC8A
     LSBio Antibodies in human, mouse, rat for RIC8A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RIC8A gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4