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Aliases for RIC8A Gene

Aliases for RIC8A Gene

  • RIC8 Guanine Nucleotide Exchange Factor A 2 3 5
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog A (C. Elegans) 2
  • Resistance To Inhibitors Of Cholinesterase 8 Homolog A 3
  • Protein Ric-8A 4
  • Synembryn-A 3
  • RIC8 3

External Ids for RIC8A Gene

Previous GeneCards Identifiers for RIC8A Gene

  • GC11P000200
  • GC11P000028

Summaries for RIC8A Gene

GeneCards Summary for RIC8A Gene

RIC8A (RIC8 Guanine Nucleotide Exchange Factor A) is a Protein Coding gene. GO annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8B.

UniProtKB/Swiss-Prot for RIC8A Gene

  • Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Gene Wiki entry for RIC8A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC8A Gene

Genomics for RIC8A Gene

Regulatory Elements for RIC8A Gene

Enhancers for RIC8A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F000266 1 FANTOM5 Ensembl ENCODE 40.7 +62.5 62542 6.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A YY1 ZNF766 CBX5 ZNF143 RIC8A IFITM2 PHRF1 PSMD13 SNORA52 SIRT3 PGGHG ENSG00000255237 ENSG00000254559 ODF3
GH11F000234 0.5 ENCODE 35.2 +29.0 29039 3.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 RIC8A PSMD13 DRD4 BET1L ENSG00000255158 SIRT3
GH11F000250 0.7 ENCODE 25.4 +43.4 43418 0.2 SMARCA5 HDGF CTCF ESRRA ZNF654 CBFB MAX TRIM22 REST RAD21 RIC8A MIR6743 BET1L NLRP6 ENSG00000255026 PGGHG GC11M000242 COX8BP
GH11F000311 1.5 FANTOM5 ENCODE 21.2 +107.4 107358 7.0 HDGF ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A ARID4B ETS1 YY1 ENSG00000254910 IFITM3 PGGHG PHRF1 IFITM2 SNORA52 RIC8A ENSG00000251661 ENSG00000255026 NLRP6
GH11F000257 0.2 Ensembl 20 +50.0 49990 0.6 MTA2 NR2F1 TBX21 SP1 POLR2A EED IKZF1 TARDBP NBN NR2F6 RIC8A NLRP6 ENSG00000255026 PGGHG MIR6743 BET1L ANO9 COX8BP GC11P000259
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RIC8A on UCSC Golden Path with GeneCards custom track

Promoters for RIC8A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000556745 389 3001 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for RIC8A Gene

Chromosome:
11
Start:
207,511 bp from pter
End:
215,175 bp from pter
Size:
7,665 bases
Orientation:
Plus strand

Genomic View for RIC8A Gene

Genes around RIC8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIC8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIC8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC8A Gene

Proteins for RIC8A Gene

  • Protein details for RIC8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPQ8-RIC8A_HUMAN
    Recommended name:
    Synembryn-A
    Protein Accession:
    Q9NPQ8
    Secondary Accessions:
    • Q0P508
    • Q2T9J1
    • Q7Z352
    • Q96EZ1
    • Q96SZ2
    • Q9H064
    • Q9H5H3
    • Q9H9E7

    Protein attributes for RIC8A Gene

    Size:
    531 amino acids
    Molecular mass:
    59710 Da
    Quaternary structure:
    • Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).
    • Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).
    SequenceCaution:
    • Sequence=BAB14282.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14282.1; Type=Frameshift; Positions=397; Evidence={ECO:0000305}; Sequence=BAB15653.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55126.1; Type=Frameshift; Positions=48; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC8A Gene

Post-translational modifications for RIC8A Gene

  • Ubiquitination at Lys 353 and Lys 409
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RIC8A Gene

Domains & Families for RIC8A Gene

Protein Domains for RIC8A Gene

Suggested Antigen Peptide Sequences for RIC8A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPQ8

UniProtKB/Swiss-Prot:

RIC8A_HUMAN :
  • Belongs to the synembryn family.
Family:
  • Belongs to the synembryn family.
genes like me logo Genes that share domains with RIC8A: view

No data available for Gene Families for RIC8A Gene

Function for RIC8A Gene

Molecular function for RIC8A Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Gene Ontology (GO) - Molecular Function for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001965 G-protein alpha-subunit binding IBA --
GO:0005085 guanyl-nucleotide exchange factor activity IEA,IBA --
GO:0005096 GTPase activator activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0030215 semaphorin receptor binding IBA --
genes like me logo Genes that share ontologies with RIC8A: view

Phenotypes for RIC8A Gene

genes like me logo Genes that share phenotypes with RIC8A: view

Animal Models for RIC8A Gene

MGI Knock Outs for RIC8A:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIC8A Gene

Localization for RIC8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC8A Gene

Cytoplasm. Cell membrane. Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIC8A Gene COMPARTMENTS Subcellular localization image for RIC8A gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm ISS,IBA --
GO:0005886 plasma membrane ISS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RIC8A: view

Pathways & Interactions for RIC8A Gene

SuperPathways for RIC8A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIC8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001755 neural crest cell migration IBA --
GO:0001944 vasculature development IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with RIC8A: view

No data available for Pathways by source and SIGNOR curated interactions for RIC8A Gene

Drugs & Compounds for RIC8A Gene

(3) Drugs for RIC8A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIC8A: view

Transcripts for RIC8A Gene

Unigene Clusters for RIC8A Gene

Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIC8A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - - - - - - - -
SP6:
SP7: - -
SP8: - - -
SP9: - - - - -
SP10: - - - -
SP11: - -
SP12:

ExUns: 12d · 12e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RIC8A Gene

GeneLoc Exon Structure for
RIC8A
ECgene alternative splicing isoforms for
RIC8A

Expression for RIC8A Gene

mRNA expression in normal human tissues for RIC8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RIC8A Gene

This gene is overexpressed in Bone (43.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIC8A Gene



Protein tissue co-expression partners for RIC8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RIC8A Gene:

RIC8A

SOURCE GeneReport for Unigene cluster for RIC8A Gene:

Hs.592292
genes like me logo Genes that share expression patterns with RIC8A: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIC8A Gene

Orthologs for RIC8A Gene

This gene was present in the common ancestor of animals.

Orthologs for RIC8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIC8A 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia RIC8A 34 35
  • 87.67 (n)
dog
(Canis familiaris)
Mammalia RIC8A 34 35
  • 87.65 (n)
mouse
(Mus musculus)
Mammalia Ric8 34 35
  • 85.47 (n)
Ric8a 16
rat
(Rattus norvegicus)
Mammalia Ric8a 34
  • 85.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RIC8A 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIC8A 34 35
  • 70.98 (n)
lizard
(Anolis carolinensis)
Reptilia RIC8A 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ric8a 34
  • 62.94 (n)
MGC76200 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22237 34
zebrafish
(Danio rerio)
Actinopterygii ric8a 34 35
  • 61.64 (n)
Dr.11062 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010793 34
  • 50.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta ric8a 34 35
  • 49.35 (n)
worm
(Caenorhabditis elegans)
Secernentea ric-8 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2446 35
  • 30 (a)
OneToMany
Species where no ortholog for RIC8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC8A Gene

ENSEMBL:
Gene Tree for RIC8A (if available)
TreeFam:
Gene Tree for RIC8A (if available)

Paralogs for RIC8A Gene

Paralogs for RIC8A Gene

(1) SIMAP similar genes for RIC8A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RIC8A: view

Variants for RIC8A Gene

Sequence variations from dbSNP and Humsavar for RIC8A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10081 -- 214,544(-) AGACC(A/G)TTGCA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1043797 -- 215,071(+) TAGCC(A/C)CAGAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111762686 -- 207,188(+) AGGGT(A/C)CTCTC intron-variant, upstream-variant-2KB
rs111991706 -- 212,721(+) GAGGG(C/T)GGCTG nc-transcript-variant, reference, missense
rs112178214 -- 207,256(+) CGTCG(G/T)TTTCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RIC8A Gene

Variant ID Type Subtype PubMed ID
dgv1010n100 CNV gain 25217958
dgv1011n100 CNV gain 25217958
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
esv22231 CNV gain 19812545
esv3625060 CNV gain 21293372
esv3625061 CNV gain 21293372
nsv1052484 CNV gain 25217958
nsv467630 CNV gain 19166990
nsv467631 CNV gain 19166990
nsv522596 CNV gain 19592680
nsv552762 CNV gain 21841781
nsv552765 CNV gain 21841781

Variation tolerance for RIC8A Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.55; 95.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIC8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIC8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIC8A Gene

Disorders for RIC8A Gene

Relevant External Links for RIC8A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIC8A

No disorders were found for RIC8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC8A Gene

Publications for RIC8A Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. (PMID: 16629901) Nishimura A. … Itoh H. (Genes Cells 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. (PMID: 10985349) Miller K.G. … Rand J.B. (Neuron 2000) 2 3 64

Products for RIC8A Gene

Sources for RIC8A Gene

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