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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIC8A Gene

protein-coding   GIFtS: 51
GCID: GC11P000200

RIC8 Guanine Nucleotide Exchange Factor A

(Previous name: resistance to inhibitors of cholinesterase 8 homolog A (C....)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RIC8 Guanine Nucleotide Exchange Factor A1 2     synembryn2
Resistance To Inhibitors Of Cholinesterase 8 Homolog A (C. Elegans)1     synembryn-A2
RIC82     Protein Ric-8A3
Resistance To Inhibitors Of Cholinesterase 8 Homolog A2     

External Ids:    HGNC: 295501   Entrez Gene: 606262   Ensembl: ENSG000001779637   OMIM: 6091465   UniProtKB: Q9NPQ83   

Export aliases for RIC8A gene to outside databases

Previous GC identifer: GC11P000028


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RIC8A Gene: 
RIC8A (RIC8 guanine nucleotide exchange factor A) is a protein-coding gene. Diseases associated with RIC8A include uterine fibroid, and neuronitis. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8B.

UniProtKB/Swiss-Prot: RIC8A_HUMAN, Q9NPQ8
Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able
to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of
microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly
leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity).
Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK
activation

Gene Wiki entry for RIC8A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIC8A gene promoter:
         RFX1   NF-1/L   NF-1   Nkx2-5   Tal-1beta   E47   Roaz   AREB6   Pax-4a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIC8A promoter sequence
   Search SABiosciences Chromatin IP Primers for RIC8A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIC8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

RIC8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIC8A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000200:  view genomic region     (about GC identifiers)

Start:
207,511 bp from pter      End:
215,113 bp from pter
Size:
7,603 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIC8A_HUMAN, Q9NPQ8 (See protein sequence)
Recommended Name: Synembryn-A  
Size: 531 amino acids; 59710 Da
Subunit: Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does
not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via
C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active
GTP-bound form of GNAI1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with RIC8A in CA2
hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity)
Sequence caution: Sequence=BAB14282.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14282.1; Type=Frameshift; Positions=397; Sequence=BAB15653.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB55126.1; Type=Frameshift; Positions=48;
Secondary accessions: Q0P508 Q2T9J1 Q7Z352 Q96EZ1 Q96SZ2 Q9H064 Q9H5H3 Q9H9E7
Alternative splicing: 4 isoforms:  Q9NPQ8-1   Q9NPQ8-2   Q9NPQ8-3   Q9NPQ8-4   

Explore the universe of human proteins at neXtProt for RIC8A: NX_Q9NPQ8

Explore proteomics data for RIC8A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPQ8

  • RIC8A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIC8A Protein Expression
    REFSEQ proteins: NP_068751.4  
    ENSEMBL proteins: 
     ENSP00000432008   ENSP00000325941   ENSP00000436610   ENSP00000435167   ENSP00000433968  
     ENSP00000434833   ENSP00000433009   ENSP00000436192   ENSP00000434896   ENSP00000431163  

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    Novus Biologicals RIC8A Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane ISS--
    GO:0016020membrane ----

    RIC8A for ontologies           About GeneDecksing



    RIC8A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR019318 Gua_nucleotide_exch_fac_Ric8
     IPR011989 ARM-like
     IPR008376 Synembryn
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9NPQ8

    ProtoNet protein and cluster: Q9NPQ8

    UniProtKB/Swiss-Prot: RIC8A_HUMAN, Q9NPQ8
    Similarity: Belongs to the synembryn family


    RIC8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIC8A_HUMAN, Q9NPQ8
    Function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able
    to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of
    microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly
    leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity).
    Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK
    activation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI16189514
         
    RIC8A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RIC8A:
     G2 arrest  Increased S DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ric8):
     behavior/neurological  cellular  mortality/aging  nervous system  other 

    RIC8A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIC8A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIC8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIC8A 
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    SwitchGear 3'UTR luciferase reporter plasmidRIC8A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RIC8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/32 Interacting proteins for RIC8A (Q9NPQ82, 3 ENSP000003259414) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN1Q9UMX02, 3, ENSP000003655764MINT-67642 I2D: score=6 STRING: ENSP00000365576
    MAPK8IP3Q9UPT62, 3MINT-65787 I2D: score=5 
    ZNF585BQ52M932, 3MINT-65222 I2D: score=4 
    TUBB2AQ138852, 3MINT-64590 I2D: score=3 
    ENSG00000096150P622693I2D: score=4 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001944vasculature development IEA--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--
    GO:0007369gastrulation ----
    GO:0008542visual learning IEA--

    RIC8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIC8A

    3 HMDB Compounds for RIC8A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RIC8A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIC8A gene: 
    NM_021932.4  

    Unigene Cluster for RIC8A:

    Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
    Hs.592292  [show with all ESTs]
    Unigene Representative Sequence: AK026897
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526104(uc001log.3) ENST00000325207(uc001lof.3) ENST00000528357
    ENST00000526982 ENST00000532373 ENST00000530889 ENST00000527696(uc001loh.3)
    ENST00000527468 ENST00000527728 ENST00000527039 ENST00000530149 ENST00000532241
    ENST00000524854 ENST00000529275 ENST00000526557 ENST00000531541
    miRNA
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    hsa-miR-875-3p hsa-miR-15a hsa-miR-3065-3p hsa-miR-29a hsa-miR-29c hsa-miR-497 hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidRIC8A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: RIC8A (NM_021932)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RIC8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RIC8A
    Sirion Biotech Customized lentivirus for stable overexpression of RIC8A 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RIC8A

    Additional mRNA sequence: 

    AK022870.1 AK026897.1 AK027090.1 AK027461.1 AK098267.1 AK225420.1 AK314568.1 AL136935.1 
    AL390088.1 BC011821.1 BC094717.1 BC111499.1 BC121807.1 BC121808.1 BX538115.1 

    24/25 DOTS entries (see all 25):

    DT.80101208  DT.100821804  DT.102840703  DT.100821814  DT.95132400  DT.92428394  DT.120712516  DT.101982355 
    DT.120712555  DT.95267637  DT.91960695  DT.102840721  DT.100821812  DT.95267633  DT.120712586  DT.120712635 
    DT.97854912  DT.100821805  DT.100821811  DT.120712561  DT.120712677  DT.95267634  DT.95267635  DT.120712679 

    24/477 AceView cDNA sequences (see all 477):

    BU630518 CB242868 AA583594 AA364929 AI566390 AA610195 BU173685 BM915572 
    BM553424 BM558410 BQ015245 AI089717 BM851185 AI081960 BM821931 BI518424 
    BQ673846 CB267481 NM_021932 BU844385 AA706144 AI144493 CD512808 BM010320 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RIC8A (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ·
    SP1:        -     -     -     -                                                     -                                                           -               
    SP2:                                                                                -                                                           -               
    SP3:                                                                                                                                                            
    SP4:                                                                                -                                                                           
    SP5:        -     -     -     -                       -     -     -     -     -     -     -                                                                     

    ExUns: 12d · 12e
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RIC8A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIC8A expression in normal human tissues (normalized intensities)      RIC8A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTGCCTCT
    RIC8A Expression
    About this image


    RIC8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Eye (Sensory Organs)
             Retina

    See RIC8A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIC8A

    SOURCE GeneReport for Unigene cluster: Hs.592292
        SABiosciences Custom PCR Arrays for RIC8A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RIC8A gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ric81 , 5 resistance to inhibitors of cholinesterase 8 homolog more1, 5 85.47(n)1
    88.11(a)1
      7 (86.06 cM)5
    1014891  NM_053194.41  NP_444424.11 
     1408569575 
    chicken
    (Gallus gallus)
    Aves RIC8A1 resistance to inhibitors of cholinesterase 8 homolog more 70.98(n)
    69.71(a)
      422987  NM_001031174.1  NP_001026345.1 
    lizard
    (Anolis carolinensis)
    Reptilia RIC8A6
    Uncharacterized protein
    66(a)
    1 ↔ 1
    1(77195334-77229580)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.222372 Xenopus laevis transcribed sequence with moderate similarity more 76.94(n)    48027955 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.110622 Transcribed sequence with weak similarity to protein more 74.73(n)    BG307071.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ric8a1 CG15797-PA 48.92(n)
    37.9(a)
      31874  NM_132322.3  NP_572550.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ric-81 Protein RIC-8 41.28(n)
    29.46(a)
      177048  NM_001028390.1  NP_001023561.1 


    ENSEMBL Gene Tree for RIC8A (if available)
    TreeFam Gene Tree for RIC8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RIC8A gene
    RIC8B2  
    1 SIMAP similar gene for RIC8A using alignment to 8 protein entries:     RIC8A_HUMAN (see all proteins):
    RIC8B

    RIC8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/182 SNPs in RIC8A are shown (see all 182)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617393861,2
    C,F--209425(+) TGCTGG/CTCTCC 2 /L /V mis14Minor allele frequency- C:0.00NS WA NA 4974
    rs1471115321,2
    C,F--209695(+) GCCTAG/CTGGTG 2 /L /V mis11Minor allele frequency- C:0.00NA 4536
    rs1995777761,2
    --209718(+) CGTGTA/GGGGCT 2 V syn10--------
    rs1165775961,2
    --209820(+) CAGCTG/ATTTCA 2 /L syn11Minor allele frequency- A:0.01NA 214
    rs2016330361,2
    --209894(+) AGGGA-/ACCCCCCA 1 T cds10--------
    rs38327971,2
    C--209895(-) TGGGT-/GGGGGGTT 1 -- cds11Minor allele frequency- GGG:0.00CSA 2
    rs2000409451,2
    --209899(+) ACCCC-/CCACCCAC 1 -- cds10--------
    rs2020160841,2
    --209908(+) CCACGA/CTCCTT 2 I L mis10--------
    rs2017118331,2
    C--209938(+) GGGCCA/GTGGAG 2 M V mis11Minor allele frequency- G:0.00EU 1233
    rs2009362401,2
    --209955(+) AAAGTA/GCTCTT 2 V syn10--------

    HapMap Linkage Disequilibrium report for RIC8A (207511 - 215113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for RIC8A (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv896437CNV Loss21882294
    nsv896441CNV Loss21882294
    nsv896439CNV Loss21882294
    nsv467630CNV Gain19166990
    nsv896440CNV Gain21882294
    nsv467631CNV Gain19166990
    nsv522596CNV Gain19592680
    esv22231CNV Gain19812545
    nsv896436CNV Gain21882294
    dgv911n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609146    OMIM disorders: --

    2 diseases for RIC8A:    About MalaCards
    uterine fibroid    neuronitis


    RIC8A for disorders           About GeneDecksing


    Export disorders for RIC8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIC8A gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RIC8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. (PubMed id 16629901)1, 2 Nishimura A....Itoh H. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. (PubMed id 10985349)1, 3 Miller K.G....Rand J.B. (2000)
    6. Ubiquitination of the heterotrimeric G protein a subun its Gai2 and Gaq is prevented by the guanine nucleotide exchange factor Ric-8A. (PubMed id 23665327)1 Chishiki K....Sumimoto H. (2013)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. NCAM180 regulates Ric8A membrane localization and pote ntiates b-adrenergic response. (PubMed id 22384181)1 Amoureux M.C....Rougon G. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60626 HGNC: 29550 AceView: RIC-8 Ensembl:ENSG00000177963 euGenes: HUgn60626
    ECgene: RIC8A H-InvDB: RIC8A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIC8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIC8A gene:
    Search GeneIP for patents involving RIC8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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