Aliases for RIC8A Gene
External Ids for RIC8A Gene
GeneCards Summary for RIC8A Gene
RIC8A (RIC8 Guanine Nucleotide Exchange Factor A) is a Protein Coding gene. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RIC8B.
UniProtKB/Swiss-Prot for RIC8A Gene
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.