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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RIC3 Gene

protein-coding   GIFtS: 51
GCID: GC11M008127

RIC3 Acetylcholine Receptor Chaperone

(Previous name: resistance to inhibitors of cholinesterase 3 homolog (C....)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RIC3 Acetylcholine Receptor Chaperone1 2     PRO13852
Resistant To Inhibitor Of Cholinesterase 32 3     Protein RIC-32
Resistance To Inhibitors Of Cholinesterase 3 Homolog (C. Elegans)1     Resistance To Inhibitors Of Cholinesterase 3 Homolog2
AYST7202     

External Ids:    HGNC: 303381   Entrez Gene: 796082   Ensembl: ENSG000001664057   OMIM: 6105095   UniProtKB: Q7Z5B43   

Export aliases for RIC3 gene to outside databases

Previous GC identifers: GC11M008086 GC11M008091 GC11M008084 GC11M007795


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RIC3 Gene:
The protein encoded by this gene promotes functional expression of homomeric nicotinic acetylcholine receptors at
the cell surface. It enhances currents generated by these receptors by expediting receptor transport to the cell
surface and by increasing receptor number. Alternatively spliced transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for RIC3 Gene: 
RIC3 (RIC3 acetylcholine receptor chaperone) is a protein-coding gene. Diseases associated with RIC3 include bipolar disorder, and schizophrenia. GO annotations related to this gene include protein binding involved in protein folding.

UniProtKB/Swiss-Prot: RIC3_HUMAN, Q7Z5B4
Function: Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the
cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of
heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4

Gene Wiki entry for RIC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RIC3 gene promoter:
         Nkx3-1   Bach1   Elk-1   Nkx3-1 v1   Nkx3-1 v2   POU2F1   Nkx6-1   POU2F1a   Pax-4a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRIC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RIC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RIC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

RIC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RIC3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M008127:  view genomic region     (about GC identifiers)

Start:
8,127,597 bp from pter      End:
8,190,602 bp from pter
Size:
63,006 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RIC3_HUMAN, Q7Z5B4 (See protein sequence)
Recommended Name: Protein RIC-3 precursor  
Size: 369 amino acids; 41092 Da
Subunit: Monomer and homodimer. Interacts with CHRNA7, CHRNA3, CHRNA4, CHRNB2, CHRNB4 and HTR3A
Subcellular location: Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein
Subcellular location: Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus
membrane; Single-pass membrane protein
Sequence caution: Sequence=BAB13871.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: B0B1U0 B2RD25 D3DQU5 Q6UX78 Q7Z5B3 Q86T94 Q8TBJ9 Q9HAH8
Alternative splicing: 5 isoforms:  Q7Z5B4-1   Q7Z5B4-2   Q7Z5B4-3   Q7Z5B4-5   Q7Z5B4-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RIC3: NX_Q7Z5B4

Explore proteomics data for RIC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z5B4

  • RIC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RIC3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001128581.1  NP_001193600.1  NP_001193601.1  NP_078833.3  

    ENSEMBL proteins: 
     ENSP00000333988   ENSP00000344904   ENSP00000308820   ENSP00000434787   ENSP00000435244  
     ENSP00000395320   ENSP00000431658   ENSP00000404415   ENSP00000443871   ENSP00000379910  

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    Cloud-Clone Corp. Proteins for RIC3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    RIC3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026160 Ric3

    Graphical View of Domain Structure for InterPro Entry Q7Z5B4

    ProtoNet protein and cluster: Q7Z5B4

    UniProtKB/Swiss-Prot: RIC3_HUMAN, Q7Z5B4
    Domain: The coiled-coil domain mediates transient homodimerization with other acetylcholine receptor-bound RIC3
    molecules, promoting stepwise ACHR homomeric assembly at the membrane (By similarity)
    Similarity: Belongs to the ric-3 family


    RIC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RIC3_HUMAN, Q7Z5B4
    Function: Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the
    cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of
    heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044183protein binding involved in protein folding IEA--
         
    RIC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RIC3:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Ric3 (no phenotypes)

    RIC3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ric3tm1Lex for RIC3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RIC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RIC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RIC3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RIC3 

    miRNA
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    hsa-miR-124* hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-29a hsa-miR-624 hsa-miR-218 hsa-miR-570 hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmidRIC3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RIC3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for RIC3 (Q7Z5B42 ENSP000003449044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    --O884472MINT-8359937
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding ----
    GO:0043623cellular protein complex assembly IEA--

    RIC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RIC3

    Search CenterWatch for drugs/clinical trials and news about RIC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RIC3 gene (4 alternative transcripts): 
    NM_001135109.2  NM_001206671.2  NM_001206672.2  NM_024557.4  

    Unigene Cluster for RIC3:

    Resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
    Hs.231850  [show with all ESTs]
    Unigene Representative Sequence: NR_045405
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335425(uc009yfm.2 uc001mge.2) ENST00000343202 ENST00000309737
    ENST00000526962 ENST00000524799 ENST00000530060 ENST00000528463 ENST00000425599
    ENST00000531450 ENST00000529271 ENST00000529035 ENST00000419822(uc001mgf.4)
    ENST00000539720 ENST00000396677(uc001mgb.2 uc010rbl.1 uc001mgd.2 uc001mgc.2 uc010rbm.1 uc009yfn.2)

    miRNA
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    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate RIC3 (see all 59):
    hsa-miR-124* hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-29a hsa-miR-624 hsa-miR-218 hsa-miR-570 hsa-miR-649
    SwitchGear 3'UTR luciferase reporter plasmidRIC3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK126081.1 AK293933.1 AK296505.1 AK315379.1 AL390131.1 AL832601.2 AM422214.1 AY326435.1 
    AY326436.1 AY358475.1 BC022455.1 BX647514.1 DQ347704.1 DQ347705.1 NR_045405.1 

    10 DOTS entries:

    DT.109495  DT.100649186  DT.424208  DT.40203027  DT.100640952  DT.101962961  DT.120705978  DT.95078744 
    DT.120705945  DT.91875837 

    24/110 AceView cDNA sequences (see all 110):

    AA384301 AI792877 AI473100 CK821454 BM353789 BG196711 BQ941375 AK022297 
    AY326435 AW271492 BG149714 AA774304 BI006675 BF727426 BM718044 BX113055 
    CA439241 AI799590 AY326436 AI018496 AI668894 AA765587 BI824766 BX647514 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RIC3 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -     -     -                       -     -                                                   
    SP2:                          -     -     -                       -     -                                                   
    SP3:                                                                    -                                                   
    SP4:                                                              -     -                             -                     
    SP5:              -     -     -     -     -     -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for RIC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RIC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAAATACC
    RIC3 Expression
    About this image


    See RIC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RIC3

    SOURCE GeneReport for Unigene cluster: Hs.231850

    UniProtKB/Swiss-Prot: RIC3_HUMAN, Q7Z5B4
    Tissue specificity: Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the
    central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in
    brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RIC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RIC3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ric31 , 5 resistance to inhibitors of cholinesterase 3 homolog more1, 5 87.92(n)1
    86.92(a)1
      7 (57.21 cM)5
    3203601  NM_001038624.11  NP_001033713.11 
     1090343125 
    chicken
    (Gallus gallus)
    Aves RIC31 resistance to inhibitors of cholinesterase 3 homolog more 65.66(n)
    65.84(a)
      423059  XM_420991.3  XP_420991.3 
    lizard
    (Anolis carolinensis)
    Reptilia RIC36
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343294.1(817267-838725)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG347834.12   -- 78.91(n)    BG347834.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5686321 protein RIC-3-like 50.47(n)
    37.54(a)
      568632  XM_691970.3  XP_697062.2 


    ENSEMBL Gene Tree for RIC3 (if available)
    TreeFam Gene Tree for RIC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1605 SNPs in RIC3 are shown (see all 1605)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363914
    A colorectal cancer sample4--see VAR_0363912 G V mis40--------
    rs759295381,2
    C,F--7794604(+) AGGTAT/GAAAAG 5 -- nc-transcript-variantut311Minor allele frequency- G:0.01WA 118
    rs43400371,2
    C,F,A,H--7794607(+) TATAAA/CAGACC 5 -- nc-transcript-variantut31 ese322Minor allele frequency- N:0.00NS EA NA WA 2558
    rs1486333671,2
    --7794697(+) TTGCCA/GGGCAG 5 -- nc-transcript-variantut310--------
    rs611333101,2
    C--7794713(+) GCAGAC/TTTGAA 5 -- nc-transcript-variantut310--------
    rs1507107631,2
    C--7794731(+) GGAAGA/GGAGGC 5 -- nc-transcript-variantut310--------
    rs1410244161,2
    C--7794897(+) GGACTA/TGACAG 5 -- nc-transcript-variantut310--------
    rs1389954021,2
    C--7794943(+) CCACA-/TGCTT 
            
    TGCTT
    5 -- nc-transcript-variantut310--------
    rs1930345091,2
    --7794951(+) CTTTGC/TCCTGG 5 -- ut31 nc-transcript-variant0--------
    rs1853698421,2
    --7795021(+) ATTCCA/CAATTC 5 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for RIC3 (8127597 - 8190602 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RIC3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744083CNV Deletion23290073
    esv2744082CNV Deletion23290073
    esv1433200CNV Insertion17803354
    esv998418CNV Insertion20482838
    nsv513307CNV Insertion21212237
    nsv428249CNV Loss18775914
    nsv896981CNV Gain21882294
    nsv7215OTHER Inversion18451855
    nsv499766OTHER Inversion21111241

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610509    OMIM disorders: --

    3 diseases for RIC3:    About MalaCards
    bipolar disorder    schizophrenia    neuronitis


    RIC3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RIC3
    Human Genome Epidemiology (HuGE) Navigator: RIC3 (5 documents)

    Export disorders for RIC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RIC3 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with RIC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. (PubMed id 12821669)1, 2, 3, 9 Halevi S....Treinin M. (2003)
    2. Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition. (PubMed id 17609200)1, 2, 9 Cheng A.... Connolly C.N. (2007)
    3. Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells. (PubMed id 15504725)1, 2, 9 Williams M.E.... Aiyar J. (2005)
    4. Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. (PubMed id 15927954)1, 2, 9 Castillo M.... Criado M. (2005)
    5. RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells. (PubMed id 16120769)1, 2, 9 Lansdell S.J.... Millar N.S. (2005)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors. (PubMed id 18691158)1, 2 Seredenina T....Roncarati R. (2008)
    8. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    9. Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3. (PubMed id 15809299)1, 2 Cheng A.... Connolly C.N. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79608 HGNC: 30338 AceView: RIC3 Ensembl:ENSG00000166405 euGenes: HUgn79608
    ECgene: RIC3 H-InvDB: RIC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RIC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RIC3 gene:
    Search GeneIP for patents involving RIC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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