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Aliases for RIC3 Gene

Aliases for RIC3 Gene

  • RIC3 Acetylcholine Receptor Chaperone 2 3 5
  • Resistant To Inhibitor Of Cholinesterase 3 3 4
  • Resistance To Inhibitors Of Cholinesterase 3 Homolog (C. Elegans) 2
  • Resistance To Inhibitors Of Cholinesterase 3-Like Protein 3
  • Resistance To Inhibitors Of Cholinesterase 3 Homolog 3
  • AYST720 3
  • PRO1385 3

External Ids for RIC3 Gene

Previous GeneCards Identifiers for RIC3 Gene

  • GC11M008086
  • GC11M008091
  • GC11M008084
  • GC11M007795
  • GC11M008127

Summaries for RIC3 Gene

Entrez Gene Summary for RIC3 Gene

  • The protein encoded by this gene promotes functional expression of homomeric nicotinic acetylcholine receptors at the cell surface. It enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RIC3 Gene

RIC3 (RIC3 Acetylcholine Receptor Chaperone) is a Protein Coding gene. GO annotations related to this gene include protein binding involved in protein folding and acetylcholine receptor binding.

UniProtKB/Swiss-Prot for RIC3 Gene

  • Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.

Gene Wiki entry for RIC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC3 Gene

Genomics for RIC3 Gene

Regulatory Elements for RIC3 Gene

Promoters for RIC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RIC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIC3 Gene

Chromosome:
11
Start:
8,092,965 bp from pter
End:
8,169,083 bp from pter
Size:
76,119 bases
Orientation:
Minus strand

Genomic View for RIC3 Gene

Genes around RIC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC3 Gene

Proteins for RIC3 Gene

  • Protein details for RIC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5B4-RIC3_HUMAN
    Recommended name:
    Protein RIC-3
    Protein Accession:
    Q7Z5B4
    Secondary Accessions:
    • B0B1U0
    • B2RD25
    • D3DQU5
    • Q6UX78
    • Q7Z5B3
    • Q86T94
    • Q8TBJ9
    • Q9HAH8

    Protein attributes for RIC3 Gene

    Size:
    369 amino acids
    Molecular mass:
    41092 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with CHRNA7, CHRNA3, CHRNA4, CHRNB2, CHRNB4 and HTR3A.
    SequenceCaution:
    • Sequence=BAB13871.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC3 Gene

Proteomics data for RIC3 Gene at MOPED

Post-translational modifications for RIC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIC3 Gene

Domains & Families for RIC3 Gene

Protein Domains for RIC3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z5B4

UniProtKB/Swiss-Prot:

RIC3_HUMAN :
  • The coiled-coil domain mediates transient homodimerization with other acetylcholine receptor-bound RIC3 molecules, promoting stepwise ACHR homomeric assembly at the membrane.
  • Belongs to the ric-3 family.
Domain:
  • The coiled-coil domain mediates transient homodimerization with other acetylcholine receptor-bound RIC3 molecules, promoting stepwise ACHR homomeric assembly at the membrane.
Family:
  • Belongs to the ric-3 family.
genes like me logo Genes that share domains with RIC3: view

No data available for Gene Families for RIC3 Gene

Function for RIC3 Gene

Molecular function for RIC3 Gene

UniProtKB/Swiss-Prot Function:
Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.

Phenotypes for RIC3 Gene

genes like me logo Genes that share phenotypes with RIC3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RIC3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIC3 Gene

Localization for RIC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC3 Gene

Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein.
Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIC3 Gene COMPARTMENTS Subcellular localization image for RIC3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 2
extracellular 2
cytoskeleton 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with RIC3: view

Pathways & Interactions for RIC3 Gene

SuperPathways for RIC3 Gene

No Data Available

Interacting Proteins for RIC3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308820%0d%0a9606.ENSP00000414982%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q7Z5B4-RIC3_HUMAN ENSP00000308820 for RIC3 Gene via MINT STRING

Gene Ontology (GO) - Biological Process for RIC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0043623 cellular protein complex assembly IEA --
genes like me logo Genes that share ontologies with RIC3: view

No data available for Pathways by source and SIGNOR curated interactions for RIC3 Gene

Drugs & Compounds for RIC3 Gene

No Compound Related Data Available

Transcripts for RIC3 Gene

Unigene Clusters for RIC3 Gene

Resistance to inhibitors of cholinesterase 3 homolog (C. elegans):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - - - - - - - -
SP6:
SP7: - - - - - - - - - - -
SP8: -
SP9:

Relevant External Links for RIC3 Gene

GeneLoc Exon Structure for
RIC3
ECgene alternative splicing isoforms for
RIC3

Expression for RIC3 Gene

mRNA expression in normal human tissues for RIC3 Gene

SOURCE GeneReport for Unigene cluster for RIC3 Gene Hs.231850

mRNA Expression by UniProt/SwissProt for RIC3 Gene

Q7Z5B4-RIC3_HUMAN
Tissue specificity: Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain.
genes like me logo Genes that share expression patterns with RIC3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RIC3 Gene

Orthologs for RIC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RIC3 35
  • 88.92 (n)
  • 86.65 (a)
RIC3 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIC3 35
  • 89.92 (n)
  • 89.37 (a)
RIC3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ric3 35
  • 87.89 (n)
  • 86.89 (a)
Ric3 16
Ric3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RIC3 35
  • 99.37 (n)
  • 99.46 (a)
RIC3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ric3 35
  • 86.7 (n)
  • 87.43 (a)
oppossum
(Monodelphis domestica)
Mammalia RIC3 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIC3 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIC3 35
  • 65.84 (n)
  • 65.84 (a)
RIC3 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIC3 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ric3 35
  • 60.86 (n)
  • 57.58 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101882410 35
  • 52.08 (n)
  • 47.5 (a)
RIC3 (1 of 2) 36
  • 24 (a)
OneToMany
RIC3 (2 of 2) 36
  • 47 (a)
OneToMany
Species with no ortholog for RIC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIC3 Gene

ENSEMBL:
Gene Tree for RIC3 (if available)
TreeFam:
Gene Tree for RIC3 (if available)

Paralogs for RIC3 Gene

No data available for Paralogs for RIC3 Gene

Variants for RIC3 Gene

Sequence variations from dbSNP and Humsavar for RIC3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17855498 - 8,140,148(+) CTGAG(A/G/T)GTGCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
VAR_036391 A colorectal cancer sample
rs55990541 - 8,138,310(+) TATAG(C/T)ATTTC intron-variant, nc-transcript-variant, reference, missense
rs1133972 -- 8,110,393(-) CTCAG(G/T)GGCAA nc-transcript-variant, utr-variant-3-prime
rs1406093 -- 8,107,657(-) GGAGT(C/T)GTGAT intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RIC3 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
nsv428249 CNV Loss 18775914
nsv896981 CNV Gain 21882294
esv998418 CNV Insertion 20482838
nsv513307 CNV Insertion 21212237
esv1433200 CNV Insertion 17803354
esv2744082 CNV Deletion 23290073
esv2744083 CNV Deletion 23290073

Variation tolerance for RIC3 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.76; 78.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIC3 Gene

HapMap Linkage Disequilibrium report
RIC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIC3 Gene

Disorders for RIC3 Gene

Relevant External Links for RIC3

Genetic Association Database (GAD)
RIC3
Human Genome Epidemiology (HuGE) Navigator
RIC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIC3

No disorders were found for RIC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC3 Gene

Publications for RIC3 Gene

  1. Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. (PMID: 12821669) Halevi S. … Treinin M. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression. (PMID: 18179477) CastelA!n F. … Criado M. (J. Neurochem. 2008) 3 23
  3. Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues. (PMID: 18208544) Lansdell S.J. … Millar N.S. (J. Neurochem. 2008) 3 23
  4. Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line. (PMID: 18471073) Roncarati R. … Terstappen G.C. (Assay Drug Dev Technol 2008) 3 23
  5. Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition. (PMID: 17609200) Cheng A. … Connolly C.N. (J. Biol. Chem. 2007) 3 23

Products for RIC3 Gene

Sources for RIC3 Gene

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