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Aliases for RIC1 Gene

Aliases for RIC1 Gene

  • RIC1 Homolog, RAB6A GEF Complex Partner 1 2 3
  • KIAA1432 2 3 4
  • Connexin-43-Interacting Protein Of 150 KDa 3 4
  • RAB6A GEF Complex Partner 1 2 3
  • Protein RIC1 Homolog 3 4
  • CIP150 3 4
  • Connexin 43-Interacting Protein 150 KDa 3
  • BA207C16.1 3

External Ids for RIC1 Gene

Previous HGNC Symbols for RIC1 Gene

  • KIAA1432

Summaries for RIC1 Gene

GeneCards Summary for RIC1 Gene

RIC1 (RIC1 Homolog, RAB6A GEF Complex Partner 1) is a Protein Coding gene. GO annotations related to this gene include Rab GTPase binding and Rab guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for RIC1 Gene

  • The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC1 Gene

Genomics for RIC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIC1 Gene

Chromosome:
9
Start:
5,629,025 bp from pter
End:
5,778,015 bp from pter
Size:
148,991 bases
Orientation:
Plus strand

Genomic View for RIC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC1 Gene

No data available for Regulatory Elements for RIC1 Gene

Proteins for RIC1 Gene

  • Protein details for RIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ADV7-RIC1_HUMAN
    Recommended name:
    RAB6A-GEF complex partner protein 1
    Protein Accession:
    Q4ADV7
    Secondary Accessions:
    • B2RN24
    • B7ZM67
    • G5E932
    • Q4VXJ8
    • Q4VXJ9
    • Q76MT5
    • Q8N6E0
    • Q8TEH4
    • Q9H0A5
    • Q9H9S1

    Protein attributes for RIC1 Gene

    Size:
    1423 amino acids
    Molecular mass:
    159301 Da
    Quaternary structure:
    • Forms a complex with RGP1; the interaction enhances RAB6A GTPase activity. Interacts (via central domain) with RGP1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts (via C-terminus domain) with RAB33B; the interaction is direct with a preference for RAB33B-GTP. Interacts with GJA1.
    SequenceCaution:
    • Sequence=AAI36617.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI44297.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14150.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE16982.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66809.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI95003.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95004.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC1 Gene

Proteomics data for RIC1 Gene at MOPED

Post-translational modifications for RIC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIC1 Gene

Domains & Families for RIC1 Gene

Protein Domains for RIC1 Gene

Suggested Antigen Peptide Sequences for RIC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4ADV7

UniProtKB/Swiss-Prot:

RIC1_HUMAN :
  • Belongs to the RIC1 family.
  • Contains 2 WD repeats.
Family:
  • Belongs to the RIC1 family.
Similarity:
  • Contains 2 WD repeats.
genes like me logo Genes that share domains with RIC1: view

No data available for Gene Families for RIC1 Gene

Function for RIC1 Gene

Molecular function for RIC1 Gene

UniProtKB/Swiss-Prot Function:
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.

Gene Ontology (GO) - Molecular Function for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23091056
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 23091056
GO:0017137 Rab GTPase binding IDA 23091056
genes like me logo Genes that share ontologies with RIC1: view
genes like me logo Genes that share phenotypes with RIC1: view

miRNA for RIC1 Gene

miRTarBase miRNAs that target RIC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RIC1 Gene

Localization for RIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC1 Gene

Cytoplasm, cytosol. Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 23091056
GO:0016020 membrane IDA 23091056
GO:0016021 integral component of membrane IEA --
GO:0034066 RIC1-RGP1 guanyl-nucleotide exchange factor complex IDA 23091056
GO:0043234 protein complex IDA 23091056
genes like me logo Genes that share ontologies with RIC1: view

No data available for Subcellular locations from COMPARTMENTS for RIC1 Gene

Pathways & Interactions for RIC1 Gene

SuperPathways for RIC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042147 retrograde transport, endosome to Golgi IMP 23091056
GO:0043547 positive regulation of GTPase activity IDA 23091056
GO:1903363 negative regulation of cellular protein catabolic process IMP 23091056
genes like me logo Genes that share ontologies with RIC1: view

No data available for Pathways by source and SIGNOR curated interactions for RIC1 Gene

Drugs & Compounds for RIC1 Gene

No Compound Related Data Available

Transcripts for RIC1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RIC1 Gene

No ASD Table

Relevant External Links for RIC1 Gene

GeneLoc Exon Structure for
RIC1
ECgene alternative splicing isoforms for
RIC1

Expression for RIC1 Gene

mRNA expression in normal human tissues for RIC1 Gene

Protein differential expression in normal tissues from HIPED for RIC1 Gene

This gene is overexpressed in Stomach (49.4) and Peripheral blood mononuclear cells (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RIC1 Gene



mRNA Expression by UniProt/SwissProt for RIC1 Gene

Q4ADV7-RIC1_HUMAN
Tissue specificity: Present in kidney and various cell lines (at protein level). Widely expressed at low level.
genes like me logo Genes that share expression patterns with RIC1: view

Protein tissue co-expression partners for RIC1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RIC1 Gene

Orthologs for RIC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA1432 35
  • 92.68 (n)
  • 95.78 (a)
KIAA1432 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1432 35
  • 90.67 (n)
  • 93.53 (a)
KIAA1432 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C030046E11Rik 35
  • 88.96 (n)
  • 92.97 (a)
C030046E11Rik 16
C030046E11Rik 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC464982 35
  • 99.78 (n)
  • 100 (a)
KIAA1432 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310016 35
  • 88.96 (n)
  • 93.25 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA1432 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA1432 35
  • 79.55 (n)
  • 83.99 (a)
KIAA1432 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1432 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1432 35
  • 73.87 (n)
  • 79.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23824 35
zebrafish
(Danio rerio)
Actinopterygii LOC100330980 35
  • 68.08 (n)
  • 74.29 (a)
KIAA1432 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010061 35
  • 47.93 (n)
  • 40.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rich 35
  • 48.93 (n)
  • 39.83 (a)
Rich 36
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R06F6.8 35
  • 44.47 (n)
  • 32.21 (a)
R06F6.8 36
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61480 35
  • 43.79 (n)
  • 31.96 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11228 35
  • 42.39 (n)
  • 29.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ric1 35
  • 42.76 (n)
  • 29.34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
CSA.4760 36
  • 10 (a)
OneToMany
Species with no ortholog for RIC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC1 Gene

ENSEMBL:
Gene Tree for RIC1 (if available)
TreeFam:
Gene Tree for RIC1 (if available)

Paralogs for RIC1 Gene

No data available for Paralogs for RIC1 Gene

Variants for RIC1 Gene

Sequence variations from dbSNP and Humsavar for RIC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs718892 -- 5,729,466(-) ACAGG(G/T)AAGAA intron-variant
rs726052 -- 5,697,396(-) TAGAT(C/G)AACCA intron-variant
rs726053 -- 5,697,461(-) TATTA(A/T)TCTAC intron-variant
rs958480 -- 5,729,377(-) AATGT(A/T)GTAGA intron-variant
rs1333193 -- 5,667,694(+) gagat(A/G)tgatc intron-variant

Variation tolerance for RIC1 Gene

Residual Variation Intolerance Score: 1.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIC1 Gene

HapMap Linkage Disequilibrium report
RIC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RIC1 Gene

Disorders for RIC1 Gene

Relevant External Links for RIC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIC1
genes like me logo Genes that share disorders with RIC1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC1 Gene

Publications for RIC1 Gene

  1. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. (PMID: 23091056) Pusapati G.V. … Pfeffer S.R. (J. Biol. Chem. 2012) 2 67
  2. Molecular cloning and functional analysis of a novel Cx43 partner protein CIP150. (PMID: 16112082) Akiyama M. … Takeya T. (Biochem. Biophys. Res. Commun. 2005) 23 67
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Genome-wide identification of genes with amplification and/or fusion in small cell lung cancer. (PMID: 23716474) Iwakawa R. … Yokota J. (Genes Chromosomes Cancer 2013) 67

Products for RIC1 Gene

Sources for RIC1 Gene

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