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Aliases for RIC1 Gene

Aliases for RIC1 Gene

  • RIC1 Homolog, RAB6A GEF Complex Partner 1 2 3 5
  • KIAA1432 2 3 4
  • Connexin-43-Interacting Protein Of 150 KDa 3 4
  • RAB6A GEF Complex Partner 1 2 3
  • Protein RIC1 Homolog 3 4
  • CIP150 3 4
  • Connexin 43-Interacting Protein 150 KDa 3
  • RAB6A-GEF Complex Partner Protein 1 3
  • BA207C16.1 3

External Ids for RIC1 Gene

Previous HGNC Symbols for RIC1 Gene

  • KIAA1432

Summaries for RIC1 Gene

GeneCards Summary for RIC1 Gene

RIC1 (RIC1 Homolog, RAB6A GEF Complex Partner 1) is a Protein Coding gene. Among its related pathways are Intra-Golgi traffic and Vesicle-mediated transport. GO annotations related to this gene include Rab GTPase binding and Rab guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for RIC1 Gene

  • The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC1 Gene

Genomics for RIC1 Gene

Regulatory Elements for RIC1 Gene

Enhancers for RIC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G004677 1.1 ENCODE 21.5 -949.5 -949507 4.4 HNRNPUL1 FOXA2 PKNOX1 CREB3L1 MLX AGO1 WRNIP1 ARID4B SIN3A DMAP1 SPATA6L RIC1 CDC37L1-AS1 CDC37L1
GH09G005623 1.7 FANTOM5 ENCODE dbSUPER 13.5 -1.8 -1786 7.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 RIC1 PLGRKT KIAA2026 CD274 RANBP6 LOC105375967 GC09P005625
GH09G004738 1.6 Ensembl ENCODE dbSUPER 14.2 -887.6 -887602 5.1 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 AK3 RIC1 CDC37L1 JAK2 PLPP6 MTND5P14 GC09P004695
GH09G004983 1.3 ENCODE dbSUPER 13.3 -643.5 -643505 3.8 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 RIC1 ENSG00000228165 MIR101-2 AK4P4 MTND6P5 MTCO1P11 JAK2 CSNK1G2P1
GH09G006014 1.1 ENCODE 13.6 +386.3 386309 2.0 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 FOS SP3 RIC1 ERMP1 RANBP6 KIAA2026
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIC1 on UCSC Golden Path with GeneCards custom track

Promoters for RIC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232864 375 3601 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 SP3 NFYC REST

Genomic Location for RIC1 Gene

Chromosome:
9
Start:
5,629,025 bp from pter
End:
5,778,015 bp from pter
Size:
148,991 bases
Orientation:
Plus strand

Genomic View for RIC1 Gene

Genes around RIC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC1 Gene

Proteins for RIC1 Gene

  • Protein details for RIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ADV7-RIC1_HUMAN
    Recommended name:
    RAB6A-GEF complex partner protein 1
    Protein Accession:
    Q4ADV7
    Secondary Accessions:
    • B2RN24
    • B7ZM67
    • G5E932
    • Q4VXJ8
    • Q4VXJ9
    • Q76MT5
    • Q8N6E0
    • Q8TEH4
    • Q9H0A5
    • Q9H9S1

    Protein attributes for RIC1 Gene

    Size:
    1423 amino acids
    Molecular mass:
    159301 Da
    Quaternary structure:
    • Forms a complex with RGP1; the interaction enhances RAB6A GTPase activity. Interacts (via central domain) with RGP1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts (via C-terminus domain) with RAB33B; the interaction is direct with a preference for RAB33B-GTP. Interacts with GJA1.
    SequenceCaution:
    • Sequence=AAI36617.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI44297.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14150.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE16982.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66809.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI95003.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95004.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC1 Gene

Post-translational modifications for RIC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIC1 Gene

Domains & Families for RIC1 Gene

Protein Domains for RIC1 Gene

Suggested Antigen Peptide Sequences for RIC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4ADV7

UniProtKB/Swiss-Prot:

RIC1_HUMAN :
  • Belongs to the RIC1 family.
Family:
  • Belongs to the RIC1 family.
genes like me logo Genes that share domains with RIC1: view

No data available for Gene Families for RIC1 Gene

Function for RIC1 Gene

Molecular function for RIC1 Gene

UniProtKB/Swiss-Prot Function:
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.

Gene Ontology (GO) - Molecular Function for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 23091056
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 23091056
GO:0017137 Rab GTPase binding IDA 23091056
genes like me logo Genes that share ontologies with RIC1: view
genes like me logo Genes that share phenotypes with RIC1: view

Animal Models for RIC1 Gene

MGI Knock Outs for RIC1:
  • Ric1 tm1a(EUCOMM)Hmgu

Animal Model Products

miRNA for RIC1 Gene

miRTarBase miRNAs that target RIC1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIC1 Gene

Localization for RIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC1 Gene

Cytoplasm, cytosol. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIC1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
peroxisome 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA,IEA 23091056
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RIC1: view

Pathways & Interactions for RIC1 Gene

genes like me logo Genes that share pathways with RIC1: view

Gene Ontology (GO) - Biological Process for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0042147 retrograde transport, endosome to Golgi IMP 23091056
GO:0043547 positive regulation of GTPase activity IDA 23091056
GO:0061024 membrane organization TAS --
GO:1903363 negative regulation of cellular protein catabolic process IMP 23091056
genes like me logo Genes that share ontologies with RIC1: view

No data available for SIGNOR curated interactions for RIC1 Gene

Transcripts for RIC1 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIC1 Gene

No ASD Table

Relevant External Links for RIC1 Gene

GeneLoc Exon Structure for
RIC1
ECgene alternative splicing isoforms for
RIC1

Expression for RIC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIC1 Gene

Protein differential expression in normal tissues from HIPED for RIC1 Gene

This gene is overexpressed in Stomach (49.4) and Peripheral blood mononuclear cells (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIC1 Gene



Protein tissue co-expression partners for RIC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIC1 Gene:

RIC1

mRNA Expression by UniProt/SwissProt for RIC1 Gene:

Q4ADV7-RIC1_HUMAN
Tissue specificity: Present in kidney and various cell lines (at protein level). Widely expressed at low level.

Evidence on tissue expression from TISSUES for RIC1 Gene

  • Nervous system(4.4)
  • Bone marrow(4.2)
  • Liver(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with RIC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIC1 Gene

Orthologs for RIC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1432 35
  • 100 (a)
OneToOne
LOC464982 34
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia KIAA1432 34 35
  • 92.68 (n)
dog
(Canis familiaris)
Mammalia KIAA1432 34 35
  • 90.67 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1432 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C030046E11Rik 34 35
  • 88.96 (n)
Ric1 16
rat
(Rattus norvegicus)
Mammalia RGD1310016 34
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 86 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA1432 34 35
  • 79.55 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1432 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1432 34
  • 73.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23824 34
zebrafish
(Danio rerio)
Actinopterygii LOC100330980 34
  • 68.08 (n)
KIAA1432 35
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rich 34 35
  • 48.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010061 34
  • 47.93 (n)
worm
(Caenorhabditis elegans)
Secernentea R06F6.8 34 35
  • 44.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61480 34
  • 43.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
CSA.4760 35
  • 10 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ric1 34
  • 42.76 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11228 34
  • 42.39 (n)
Species where no ortholog for RIC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC1 Gene

ENSEMBL:
Gene Tree for RIC1 (if available)
TreeFam:
Gene Tree for RIC1 (if available)

Paralogs for RIC1 Gene

No data available for Paralogs for RIC1 Gene

Variants for RIC1 Gene

Sequence variations from dbSNP and Humsavar for RIC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000005469 -- 5,744,065(+) TATTT(C/T)AGTCT intron-variant
rs1000007067 -- 5,635,339(+) GTCTT(C/T)AATCC intron-variant
rs1000015801 -- 5,643,815(+) CAATT(A/T)AAAAA intron-variant
rs1000020416 -- 5,761,220(+) GTGAT(C/T)CTCCT intron-variant
rs1000037977 -- 5,666,423(+) TACTA(G/T)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIC1 Gene

Variant ID Type Subtype PubMed ID
dgv1320e199 CNV deletion 23128226
esv2158152 CNV deletion 18987734
esv23270 CNV loss 19812545
esv24276 CNV loss 19812545
esv2543160 CNV deletion 19546169
esv2666049 CNV deletion 23128226
esv2738163 CNV deletion 23290073
esv3268941 CNV deletion 24192839
esv3544465 CNV deletion 23714750
esv3573095 CNV loss 25503493
esv3619384 CNV loss 21293372
esv3619386 CNV loss 21293372
esv3619387 CNV loss 21293372
esv3619388 CNV loss 21293372
esv995651 CNV deletion 20482838
nsv1029665 CNV gain 25217958
nsv1073863 CNV deletion 25765185
nsv1115152 CNV deletion 24896259
nsv613202 CNV loss 21841781
nsv6462 CNV deletion 18451855
nsv824830 CNV gain 20364138
nsv957111 CNV deletion 24416366
nsv972645 CNV duplication 23825009

Variation tolerance for RIC1 Gene

Residual Variation Intolerance Score: 1.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIC1 Gene

Disorders for RIC1 Gene

Relevant External Links for RIC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIC1

No disorders were found for RIC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC1 Gene

Publications for RIC1 Gene

  1. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. (PMID: 23091056) Pusapati G.V. … Pfeffer S.R. (J. Biol. Chem. 2012) 2 3 4 64
  2. Molecular cloning and functional analysis of a novel Cx43 partner protein CIP150. (PMID: 16112082) Akiyama M. … Takeya T. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for RIC1 Gene

Sources for RIC1 Gene

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