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Aliases for RIC1 Gene

Aliases for RIC1 Gene

  • RIC1 Homolog, RAB6A GEF Complex Partner 1 2 3 5
  • KIAA1432 2 3 4
  • Connexin-43-Interacting Protein Of 150 KDa 3 4
  • RAB6A GEF Complex Partner 1 2 3
  • Protein RIC1 Homolog 3 4
  • CIP150 3 4
  • Connexin 43-Interacting Protein 150 KDa 3
  • RAB6A-GEF Complex Partner Protein 1 3
  • BA207C16.1 3

External Ids for RIC1 Gene

Previous HGNC Symbols for RIC1 Gene

  • KIAA1432

Summaries for RIC1 Gene

GeneCards Summary for RIC1 Gene

RIC1 (RIC1 Homolog, RAB6A GEF Complex Partner 1) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Retrograde transport at the Trans-Golgi-Network. GO annotations related to this gene include Rab GTPase binding and Rab guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for RIC1 Gene

  • The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.

Additional gene information for RIC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIC1 Gene

Genomics for RIC1 Gene

Regulatory Elements for RIC1 Gene

Enhancers for RIC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H005623 1.7 FANTOM5 ENCODE dbSUPER 13.5 -1.8 -1786 7 PKNOX1 ARID4B SIN3A ZNF766 ZNF143 ZNF207 SP3 JUNB REST ZNF592 RIC1 PLGRKT KIAA2026 CD274 RANBP6 GC09P005625 LOC105375967
GH09H004738 1.6 Ensembl ENCODE dbSUPER 11.1 -887.6 -887602 5 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 AK3 CDC37L1 RIC1 JAK2 PLPP6 MTND5P14 GC09P004695
GH09H005620 0.9 Ensembl ENCODE 16 -7.2 -7189 1 ZNF664 GTF3C2 PRDM6 JUND JUN CEBPB FOS EP300 RIC1 UHRF2 AK4P4 PDCD1LG2 PLGRKT GC09P005625 GC09M005608
GH09H006006 1.1 ENCODE 12.6 +378.9 378918 3 HDGF PKNOX1 ATF1 ARID4B SIN3A BRCA1 YY1 GLIS2 ELK1 ZNF207 UHRF2 RIC1 AK4P4 PDSS1P1 ERMP1 MIR4665 KIAA2026
GH09H006411 1.1 ENCODE 11.1 +784.7 784725 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 YY1 GLIS2 ZNF207 UHRF2 ENSG00000233367 RIC1 KDM4C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIC1 on UCSC Golden Path with GeneCards custom track

Promoters for RIC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232864 375 3601 PKNOX1 ATF1 ARID4B SIN3A TCF12 GLIS2 GATA2 ZNF143 ZNF207 ATF7

Genomic Location for RIC1 Gene

Chromosome:
9
Start:
5,629,025 bp from pter
End:
5,778,015 bp from pter
Size:
148,991 bases
Orientation:
Plus strand

Genomic View for RIC1 Gene

Genes around RIC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIC1 Gene

Proteins for RIC1 Gene

  • Protein details for RIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4ADV7-RIC1_HUMAN
    Recommended name:
    RAB6A-GEF complex partner protein 1
    Protein Accession:
    Q4ADV7
    Secondary Accessions:
    • B2RN24
    • B7ZM67
    • G5E932
    • Q4VXJ8
    • Q4VXJ9
    • Q76MT5
    • Q8N6E0
    • Q8TEH4
    • Q9H0A5
    • Q9H9S1

    Protein attributes for RIC1 Gene

    Size:
    1423 amino acids
    Molecular mass:
    159301 Da
    Quaternary structure:
    • Forms a complex with RGP1; the interaction enhances RAB6A GTPase activity. Interacts (via central domain) with RGP1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts (via C-terminus domain) with RAB33B; the interaction is direct with a preference for RAB33B-GTP. Interacts with GJA1.
    SequenceCaution:
    • Sequence=AAI36617.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI44297.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14150.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAE16982.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66809.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI95003.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95004.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RIC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIC1 Gene

Post-translational modifications for RIC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIC1 Gene

Domains & Families for RIC1 Gene

Gene Families for RIC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RIC1 Gene

Suggested Antigen Peptide Sequences for RIC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4ADV7

UniProtKB/Swiss-Prot:

RIC1_HUMAN :
  • Belongs to the RIC1 family.
Family:
  • Belongs to the RIC1 family.
genes like me logo Genes that share domains with RIC1: view

Function for RIC1 Gene

Molecular function for RIC1 Gene

UniProtKB/Swiss-Prot Function:
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.

Gene Ontology (GO) - Molecular Function for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 23091056
GO:0017112 Rab guanyl-nucleotide exchange factor activity IDA 23091056
GO:0017137 Rab GTPase binding IDA 23091056
genes like me logo Genes that share ontologies with RIC1: view
genes like me logo Genes that share phenotypes with RIC1: view

Animal Models for RIC1 Gene

MGI Knock Outs for RIC1:
  • Ric1 tm1a(EUCOMM)Hmgu

Animal Model Products

CRISPR Products

miRNA for RIC1 Gene

miRTarBase miRNAs that target RIC1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RIC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIC1 Gene

Localization for RIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIC1 Gene

Cytoplasm, cytosol. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIC1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
peroxisome 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA,IDA 23091056
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RIC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RIC1 Gene

Pathways & Interactions for RIC1 Gene

genes like me logo Genes that share pathways with RIC1: view

Gene Ontology (GO) - Biological Process for RIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0042147 retrograde transport, endosome to Golgi IMP 23091056
GO:0043547 positive regulation of GTPase activity IDA 23091056
GO:0061024 membrane organization TAS --
GO:1903363 negative regulation of cellular protein catabolic process IMP 23091056
genes like me logo Genes that share ontologies with RIC1: view

No data available for SIGNOR curated interactions for RIC1 Gene

Drugs & Compounds for RIC1 Gene

No Compound Related Data Available

Transcripts for RIC1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RIC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RIC1 Gene

No ASD Table

Relevant External Links for RIC1 Gene

GeneLoc Exon Structure for
RIC1
ECgene alternative splicing isoforms for
RIC1

Expression for RIC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIC1 Gene

Protein differential expression in normal tissues from HIPED for RIC1 Gene

This gene is overexpressed in Stomach (49.4) and Peripheral blood mononuclear cells (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIC1 Gene



Protein tissue co-expression partners for RIC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIC1 Gene:

RIC1

mRNA Expression by UniProt/SwissProt for RIC1 Gene:

Q4ADV7-RIC1_HUMAN
Tissue specificity: Present in kidney and various cell lines (at protein level). Widely expressed at low level.

Evidence on tissue expression from TISSUES for RIC1 Gene

  • Nervous system(4.4)
  • Bone marrow(4.2)
  • Liver(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with RIC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIC1 Gene

Orthologs for RIC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RIC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1432 34
  • 100 (a)
OneToOne
LOC464982 33
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia KIAA1432 33 34
  • 92.68 (n)
dog
(Canis familiaris)
Mammalia KIAA1432 33 34
  • 90.67 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1432 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia C030046E11Rik 33 34
  • 88.96 (n)
Ric1 16
rat
(Rattus norvegicus)
Mammalia RGD1310016 33
  • 88.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA1432 33 34
  • 79.55 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1432 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1432 33
  • 73.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23824 33
zebrafish
(Danio rerio)
Actinopterygii LOC100330980 33
  • 68.08 (n)
KIAA1432 34
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rich 33 34
  • 48.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010061 33
  • 47.93 (n)
worm
(Caenorhabditis elegans)
Secernentea R06F6.8 33 34
  • 44.47 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61480 33
  • 43.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToMany
CSA.4760 34
  • 10 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ric1 33
  • 42.76 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11228 33
  • 42.39 (n)
Species where no ortholog for RIC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIC1 Gene

ENSEMBL:
Gene Tree for RIC1 (if available)
TreeFam:
Gene Tree for RIC1 (if available)

Paralogs for RIC1 Gene

No data available for Paralogs for RIC1 Gene

Variants for RIC1 Gene

Sequence variations from dbSNP and Humsavar for RIC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000005469 -- 5,744,065(+) TATTT(C/T)AGTCT intron-variant
rs1000007067 -- 5,635,339(+) GTCTT(C/T)AATCC intron-variant
rs1000015801 -- 5,643,815(+) CAATT(A/T)AAAAA intron-variant
rs1000020416 -- 5,761,220(+) GTGAT(C/T)CTCCT intron-variant
rs1000037977 -- 5,666,423(+) TACTA(G/T)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIC1 Gene

Variant ID Type Subtype PubMed ID
dgv1320e199 CNV deletion 23128226
esv2158152 CNV deletion 18987734
esv23270 CNV loss 19812545
esv24276 CNV loss 19812545
esv2543160 CNV deletion 19546169
esv2666049 CNV deletion 23128226
esv2738163 CNV deletion 23290073
esv3268941 CNV deletion 24192839
esv3544465 CNV deletion 23714750
esv3573095 CNV loss 25503493
esv3619384 CNV loss 21293372
esv3619386 CNV loss 21293372
esv3619387 CNV loss 21293372
esv3619388 CNV loss 21293372
esv995651 CNV deletion 20482838
nsv1029665 CNV gain 25217958
nsv1073863 CNV deletion 25765185
nsv1115152 CNV deletion 24896259
nsv613202 CNV loss 21841781
nsv6462 CNV deletion 18451855
nsv824830 CNV gain 20364138
nsv957111 CNV deletion 24416366
nsv972645 CNV duplication 23825009

Variation tolerance for RIC1 Gene

Residual Variation Intolerance Score: 1.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIC1 Gene

Human Gene Mutation Database (HGMD)
RIC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIC1 Gene

Disorders for RIC1 Gene

Relevant External Links for RIC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIC1

No disorders were found for RIC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIC1 Gene

Publications for RIC1 Gene

  1. Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase. (PMID: 23091056) Pusapati GV … Pfeffer SR (The Journal of biological chemistry 2012) 2 3 4 60
  2. Molecular cloning and functional analysis of a novel Cx43 partner protein CIP150. (PMID: 16112082) Akiyama M … Takeya T (Biochemical and biophysical research communications 2005) 3 4 22 60
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 60

Products for RIC1 Gene

Sources for RIC1 Gene

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