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Aliases for RIBC2 Gene

Aliases for RIBC2 Gene

  • RIB43A Domain With Coiled-Coils 2 2 3 5
  • C22orf11 3 4
  • RIB43A-Like With Coiled-Coils Protein 2 3
  • Chromosome 22 Open Reading Frame 11 2
  • TRIB 3

External Ids for RIBC2 Gene

Previous HGNC Symbols for RIBC2 Gene

  • C22orf11

Previous GeneCards Identifiers for RIBC2 Gene

  • GC22P044130
  • GC22P045809
  • GC22P028755

Summaries for RIBC2 Gene

GeneCards Summary for RIBC2 Gene

RIBC2 (RIB43A Domain With Coiled-Coils 2) is a Protein Coding gene. An important paralog of this gene is RIBC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIBC2 Gene

Genomics for RIBC2 Gene

Regulatory Elements for RIBC2 Gene

Enhancers for RIBC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RIBC2 on UCSC Golden Path with GeneCards custom track

Promoters for RIBC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RIBC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RIBC2 Gene

45,413,691 bp from pter
45,432,496 bp from pter
18,806 bases
Plus strand

Genomic View for RIBC2 Gene

Genes around RIBC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIBC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIBC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIBC2 Gene

Proteins for RIBC2 Gene

  • Protein details for RIBC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RIB43A-like with coiled-coils protein 2
    Protein Accession:
    Secondary Accessions:
    • Q6ICD0
    • Q9Y413

    Protein attributes for RIBC2 Gene

    309 amino acids
    Molecular mass:
    37060 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RIBC2 Gene

Post-translational modifications for RIBC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIBC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RIBC2 Gene

Domains & Families for RIBC2 Gene

Protein Domains for RIBC2 Gene


Suggested Antigen Peptide Sequences for RIBC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RIB43A family.
  • Belongs to the RIB43A family.
genes like me logo Genes that share domains with RIBC2: view

No data available for Gene Families for RIBC2 Gene

Function for RIBC2 Gene

Gene Ontology (GO) - Molecular Function for RIBC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
genes like me logo Genes that share ontologies with RIBC2: view

Phenotypes for RIBC2 Gene

genes like me logo Genes that share phenotypes with RIBC2: view

Animal Model Products

CRISPR Products

miRNA for RIBC2 Gene

miRTarBase miRNAs that target RIBC2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIBC2 Gene

Localization for RIBC2 Gene

Subcellular locations from

Jensen Localization Image for RIBC2 Gene COMPARTMENTS Subcellular localization image for RIBC2 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RIBC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with RIBC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RIBC2 Gene

Pathways & Interactions for RIBC2 Gene

SuperPathways for RIBC2 Gene

No Data Available

Interacting Proteins for RIBC2 Gene

Gene Ontology (GO) - Biological Process for RIBC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RIBC2 Gene

Drugs & Compounds for RIBC2 Gene

No Compound Related Data Available

Transcripts for RIBC2 Gene

Unigene Clusters for RIBC2 Gene

RIB43A domain with coiled-coils 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIBC2 Gene

No ASD Table

Relevant External Links for RIBC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIBC2 Gene

mRNA expression in normal human tissues for RIBC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIBC2 Gene

This gene is overexpressed in Testis (x27.9).

Protein differential expression in normal tissues from HIPED for RIBC2 Gene

This gene is overexpressed in Frontal cortex (39.5) and Fetal heart (29.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RIBC2 Gene

Protein tissue co-expression partners for RIBC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIBC2 Gene:


SOURCE GeneReport for Unigene cluster for RIBC2 Gene:

genes like me logo Genes that share expression patterns with RIBC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RIBC2 Gene

Orthologs for RIBC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIBC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RIBC2 34
  • 85.41 (n)
  • 81.17 (a)
RIBC2 35
  • 80 (a)
(Canis familiaris)
Mammalia RIBC2 34
  • 86.03 (n)
  • 84.35 (a)
RIBC2 35
  • 84 (a)
(Mus musculus)
Mammalia Ribc2 34
  • 79.31 (n)
  • 70.03 (a)
Ribc2 16
Ribc2 35
  • 70 (a)
(Pan troglodytes)
Mammalia RIBC2 34
  • 99.2 (n)
  • 98.41 (a)
RIBC2 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Ribc2 34
  • 79.84 (n)
  • 70.82 (a)
(Monodelphis domestica)
Mammalia RIBC2 35
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia RIBC2 35
  • 55 (a)
(Gallus gallus)
Aves RIBC2 34
  • 63.34 (n)
  • 58.76 (a)
RIBC2 35
  • 58 (a)
(Anolis carolinensis)
Reptilia RIBC2 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ribc2 34
  • 59.87 (n)
  • 54.16 (a)
(Danio rerio)
Actinopterygii ribc2 34
  • 49.44 (n)
  • 40.96 (a)
ribc2 35
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001735 34
  • 48.85 (n)
  • 39.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7264 34
  • 42.88 (n)
  • 31.56 (a)
CG7264 35
  • 31 (a)
Species where no ortholog for RIBC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIBC2 Gene

Gene Tree for RIBC2 (if available)
Gene Tree for RIBC2 (if available)

Paralogs for RIBC2 Gene

Paralogs for RIBC2 Gene

(1) SIMAP similar genes for RIBC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RIBC2: view

Variants for RIBC2 Gene

Sequence variations from dbSNP and Humsavar for RIBC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2142661 - 45,426,029(+) TCCTG(C/T)GTGGG reference, missense
rs1022478 - 45,426,076(+) TCCTT(C/G/T)GGGCC reference, missense
rs2072770 - 45,431,000(+) GCGGC(A/G)GCAGC reference, missense
rs717294 -- 45,429,781(-) CAGCA(A/G)TACTG intron-variant
rs717295 -- 45,429,741(-) CCAGA(C/T)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RIBC2 Gene

Variant ID Type Subtype PubMed ID
esv2724402 CNV deletion 23290073
esv2758843 CNV gain 17122850
esv34218 CNV gain 17911159
esv3647921 CNV gain 21293372
esv3647931 CNV gain 21293372
esv3647932 CNV gain 21293372
esv3647933 CNV loss 21293372
esv3893490 CNV gain 25118596
nsv1066204 CNV gain 25217958
nsv3651 CNV insertion 18451855
nsv471210 CNV gain 18288195
nsv515690 CNV gain+loss 19592680
nsv525550 CNV loss 19592680
nsv834221 CNV loss 17160897
nsv9921 CNV gain+loss 18304495

Variation tolerance for RIBC2 Gene

Gene Damage Index Score: 7.41; 81.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIBC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIBC2 Gene

Disorders for RIBC2 Gene

Relevant External Links for RIBC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RIBC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIBC2 Gene

Publications for RIBC2 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 65
  5. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3 65

Products for RIBC2 Gene

Sources for RIBC2 Gene