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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHPN2 Gene

protein-coding   GIFtS: 58
GCID: GC19M033469

Rhophilin, Rho GTPase Binding Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rhophilin, Rho GTPase Binding Protein 21 2     Rhophilin 22
76 KDa RhoB Effector Protein2 3     rhophilin-22
GTP-Rho-Binding Protein 22 3     Rhophilin-Like Rho-GTPase Binding Protein2
P76RBE2     p76RBE3
RHOBP2     

External Ids:    HGNC: 199741   Entrez Gene: 854152   Ensembl: ENSG000001319417   UniProtKB: Q8IUC43   

Export aliases for RHPN2 gene to outside databases

Previous GC identifers: GC19M033918 GC19M038145 GC19M038161 GC19M029972


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHPN2 Gene:
This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded
protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the
actin cytoskeleton. (provided by RefSeq, Apr 2009)

GeneCards Summary for RHPN2 Gene: 
RHPN2 (rhophilin, Rho GTPase binding protein 2) is a protein-coding gene. Diseases associated with RHPN2 include pituitary adenoma, and adenoma, and among its related super-pathways are G-protein signaling RhoB regulation pathway and Actin Nucleation by ARP-WASP Complex. An important paralog of this gene is PDCD6IP.

UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4
Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or
increase the turnover of F-actin structures in the absence of high levels of RhoA activity

Gene Wiki entry for RHPN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHPN2 gene promoter:
         Sox5   Pax-5   GR-beta   GCNF   LCR-F1   SRY   GCNF-1   GR-alpha   GCNF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHPN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RHPN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHPN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.12

RHPN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHPN2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M033469:  view genomic region     (about GC identifiers)

Start:
33,469,498 bp from pter      End:
33,555,824 bp from pter
Size:
86,327 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4 (See protein sequence)
Recommended Name: Rhophilin-2  
Size: 686 amino acids; 76993 Da
Subunit: Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. According to
PubMed:12473120, it does not interact with RhoA. Interacts with KRT18
Subcellular location: Cytoplasm, perinuclear region
1 PDB 3D structure from and Proteopedia for RHPN2:
2VSV (3D)    
Secondary accessions: Q8N3T7 Q8N9D6 Q8NE33 Q96RU1

Explore the universe of human proteins at neXtProt for RHPN2: NX_Q8IUC4

Explore proteomics data for RHPN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IUC4

  • RHPN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHPN2 Protein Expression
    REFSEQ proteins: NP_149094.3  
    ENSEMBL proteins: 
     ENSP00000254260   ENSP00000465898   ENSP00000402244  

    Human Recombinant Protein Products for RHPN2: 
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    GenScript Custom Purified and Recombinant Proteins Services for RHPN2
    Novus Biologicals RHPN2 Proteins
    Novus Biologicals RHPN2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHPN2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048471perinuclear region of cytoplasm IEA--

    RHPN2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for RHPN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR004328 BRO1_dom
     IPR001478 PDZ
     IPR011072 HR1_rho-bd

    Graphical View of Domain Structure for InterPro Entry Q8IUC4

    ProtoNet protein and cluster: Q8IUC4

    3 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB004328 BRO1-like domain
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4
    Similarity: Belongs to the RHPN family
    Similarity: Contains 1 BRO1 domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 REM (Hr1) repeat


    RHPN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHPN2_HUMAN, Q8IUC4
    Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or
    increase the turnover of F-actin structures in the absence of high levels of RhoA activity
    Induction: By thyrotropin (TSH). Regulated by the cAMP pathway

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    RHPN2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RHPN2:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rhpn2):
     normal 

    RHPN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rhpn2tm1Ssch for RHPN2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHPN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHPN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHPN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHPN2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHPN2
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RHPN2 (see all 32):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-3152-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidRHPN2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHPN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHPN2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-protein signaling RhoB regulation pathway
    G-protein signaling RhoB regulation pathway1.00
    2Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35
    3G13 Signaling Pathway
    G13 Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RHPN2
        G-protein signaling RhoB regulation pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RHPN2
        RhoA Pathway

    1 GeneGo (Thomson Reuters) Pathway for RHPN2
        G-protein signaling RhoB regulation pathway

    1 BioSystems Pathway for RHPN2
        G13 Signaling Pathway



    RHPN2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHPN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/23 Interacting proteins for RHPN2 (Q8IUC42, 3 ENSP000002542604) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3975242 I2D: score=2 
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    HLA-CP305043I2D: score=1 
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--

    RHPN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHPN2

    2 HMDB Compounds for RHPN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RHPN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHPN2 gene: 
    NM_033103.4  

    Unigene Cluster for RHPN2:

    Rhophilin, Rho GTPase binding protein 2
    Hs.466435  [show with all ESTs]
    Unigene Representative Sequence: AK126506
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544458(uc002nue.3) ENST00000254260(uc002nuf.3 uc010xro.2)
    ENST00000588388 ENST00000588683 ENST00000592247 ENST00000591502 ENST00000585641
    ENST00000400226
    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RHPN2 (see all 32):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-3152-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidRHPN2 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of RHPN2 
    Primer
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    OriGene qPCR primer pairs and template standards for RHPN2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHPN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHPN2

    Additional mRNA sequence: 

    AF268032.1 AF423421.1 AJ347750.1 AK026894.1 AK095001.1 AK098246.1 AK126506.1 AK300775.1 
    AK315105.1 AL831950.1 BC036447.2 

    7 DOTS entries:

    DT.75101237  DT.40117822  DT.100747243  DT.422285  DT.95373255  DT.95373256  DT.101966949 

    24/78 AceView cDNA sequences (see all 78):

    BX382116 AJ347750 BC036447 AA235454 AK026894 NM_033103 AI962973 BQ233061 
    BG259898 AA464079 AA463944 AI127133 AA464018 BE766635 AW513172 BM698463 
    AA464728 BU173824 BE786061 BF196068 AI859849 AF423421 AW439625 CF141783 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHPN2 expression in normal human tissues (normalized intensities)      RHPN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTATACA
    RHPN2 Expression
    About this image


    RHPN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Kidney (Urinary System)
             Human Renal Proximal Tubular Epithelial Cells (HRPTEpiC)   
     
     Lung (Respiratory System)
             trachea   

    See RHPN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHPN2

    SOURCE GeneReport for Unigene cluster: Hs.466435

    UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4
    Tissue specificity: Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas.
    Expressed at lower level in brain, spinal cord, kidney, placenta and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHPN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHPN2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhpn21 , 5 rhophilin, Rho GTPase binding protein 21, 5 82.7(n)1
    85.86(a)1
      7 (21.36 cM)5
    524281  NM_027897.41  NP_082173.31 
     353341755 
    chicken
    (Gallus gallus)
    Aves RHPN21 rhophilin, Rho GTPase binding protein 2 69.42(n)
    71.72(a)
      415771  XM_414133.3  XP_414133.2 
    lizard
    (Anolis carolinensis)
    Reptilia RHPN26
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343483.1(21236-51953)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.27122 Xenopus laevis transcribed sequence with moderate similarity more 74.12(n)    BQ385790.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559602 similar to rhophilin-2 75.54(n)   394153  BC044556.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rhp6
    Rhophilin
    32(a)
    1 → many
    X(15682926-15687780)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BRO16
    Cytoplasmic class E vacuolar protein sorting (VPS)...
    9(a)
    1 → many
    XVI(394038-396572)


    ENSEMBL Gene Tree for RHPN2 (if available)
    TreeFam Gene Tree for RHPN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHPN2 gene
    PDCD6IP2  PTPN232  RHPN12  
    2 SIMAP similar genes for RHPN2 using alignment to 4 protein entries:     RHPN2_HUMAN (see all proteins):
    RHPN2P1    RHPN1

    RHPN2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RHPN2
    PGOHUM00000258803 PGOHUM00000259128


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2060 SNPs in RHPN2 are shown (see all 2060)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498330091,2
    Cuntested133512507(+) TCTTTC/TGTTTC 2 T syn11Minor allele frequency- T:0.00NA 4550
    rs713405151,2
    C--30000476(+) ATCTC-/ATAAATAA/
    ATAAATAAATAA
    ATAAA
    1 -- int11NA 2
    rs742573441,2
    C--33469015(+) GGCCAG/CGCACA 1 -- ds50014Minor allele frequency- C:0.16NA WA EA 360
    rs1410334271,2
    --33469034(+) CACCTA/GTAGTC 1 -- ds50010--------
    rs72518651,2
    C,A--33469168(+) tcatgT/Cctgta 1 -- ds50013Minor allele frequency- C:0.00NA CSA 4
    rs1825147381,2
    --33469329(+) AAAGAC/TACCAT 1 -- ds50010--------
    rs1871667851,2
    C--33469482(+) AAAGTA/CAAAAG 1 -- ds50010--------
    rs757705231,2
    C,F--33469527(+) AAATAT/CGTATA 1 -- ut313Minor allele frequency- C:0.05WA NA EA 358
    rs1903440731,2
    --33469551(+) AGGAGC/TAGCAG 1 -- ut310--------
    rs81097981,2
    C,F,A,H--33469577(+) GGTGGT/GTGCTT 1 -- ut3129Minor allele frequency- G:0.15NS EA NA WA CSA 3084

    HapMap Linkage Disequilibrium report for RHPN2 (33469498 - 33555824 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RHPN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2462CNV Loss18451855
    nsv833807CNV Loss17160897
    esv28223CNV Gain19812545
    nsv828524CNV Gain20364138
    nsv9705CNV Gain18304495


    Human Gene Mutation Database (HGMD): RHPN2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for RHPN2:    About MalaCards
    pituitary adenoma    adenoma    colorectal cancer    thyroiditis
    prostatitis


    RHPN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RHPN2
    Human Genome Epidemiology (HuGE) Navigator: RHPN2 (9 documents)

    Export disorders for RHPN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHPN2 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with RHPN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. (PubMed id 12221077)1, 2, 3, 9 Peck J.W.... Burbelo P.D. (2002)
    2. Genetic heterogeneity in colorectal cancer associatio ns between African and European americans. (PubMed id 20659471)1, 4 Kupfer S.S....Ellis N.A. (2010)
    3. Risk of genome-wide association study-identified gene tic variants for colorectal cancer in a Chinese population. (PubMed id 20530476)1, 4 Xiong F....Lin D. (2010)
    4. The utility and predictive value of combinations of l ow penetrance genes for screening and risk prediction of colorectal cancer. (PubMed id 20437058)1, 4 Hawken S.J....Little J. (2010)
    5. Association studies on 11 published colorectal cancer risk loci. (PubMed id 20648012)1, 4 von Holst S....Lindblom A. (2010)
    6. Susceptibility genetic variants associated with color ectal cancer risk correlate with cancer phenotype. (PubMed id 20638935)1, 4 AbulA- A....Andreu M. (2010)
    7. Low-penetrance susceptibility variants in familial co lorectal cancer. (PubMed id 20501757)1, 4 NiittymAoki I....Aaltonen L.A. (2010)
    8. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. (PubMed id 19011631)1, 4 Houlston R.S....Dunlop M.G. (2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85415 HGNC: 19974 AceView: RHPN2 Ensembl:ENSG00000131941 euGenes: HUgn85415
    ECgene: RHPN2 H-InvDB: RHPN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHPN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHPN2 gene:
    Search GeneIP for patents involving RHPN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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