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Aliases for RHPN2 Gene

Aliases for RHPN2 Gene

  • Rhophilin Rho GTPase Binding Protein 2 2 3 5
  • 76 KDa RhoB Effector Protein 3 4
  • GTP-Rho-Binding Protein 2 3 4
  • P76RBE 3 4
  • Rhophilin-Like Rho-GTPase Binding Protein 3
  • Rhophilin-2 3
  • RHOBP 3

External Ids for RHPN2 Gene

Previous GeneCards Identifiers for RHPN2 Gene

  • GC19M033918
  • GC19M038145
  • GC19M038161
  • GC19M033469
  • GC19M029972

Summaries for RHPN2 Gene

Entrez Gene Summary for RHPN2 Gene

  • This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]

GeneCards Summary for RHPN2 Gene

RHPN2 (Rhophilin Rho GTPase Binding Protein 2) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex and RHO GTPases Activate Rhotekin and Rhophilins. An important paralog of this gene is RHPN1.

UniProtKB/Swiss-Prot for RHPN2 Gene

  • Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.

Gene Wiki entry for RHPN2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHPN2 Gene

Genomics for RHPN2 Gene

Regulatory Elements for RHPN2 Gene

Enhancers for RHPN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G033039 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25.8 +23.0 23045 6.3 HNRNPUL1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 FOS SP3 GPATCH1 PDCD5 RHPN2 FAAP24 CHST8 CEP89 ANKRD27 NUDT19 ENSG00000267611 GC19M033010
GH19G033045 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22 +16.6 16567 4.9 BRCA1 TCF12 ZNF766 GATA2 FOS MBD2 ZNF610 PBX2 GLIS1 HMBOX1 GPATCH1 RHPN2 PDCD5 FAAP24 CEP89 NUDT19 ENSG00000267611 GC19M033010
GH19G033051 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.4 +11.1 11097 5.6 PKNOX1 FOXA2 ZNF133 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF121 ZNF143 GPATCH1 RHPN2 FAAP24 WDR88 ENSG00000267611
GH19G033062 1.3 ENCODE dbSUPER 18 +0.7 702 2.7 ATF1 SIN3A DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 KLF7 ZNF263 ZNF202 GPATCH1 RHPN2 WDR88 ENSG00000267611
GH19G033100 1.3 ENCODE dbSUPER 17.2 -36.2 -36168 1.9 HDGF PKNOX1 FOXA2 ATF1 ARNT SIN3A TCF12 ZNF766 GATA2 FOS RHPN2 WDR88 GPATCH1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHPN2 on UCSC Golden Path with GeneCards custom track

Promoters for RHPN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108757 418 1801 ATF1 MLX SIN3A DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 KLF7 ZNF263

Genomic Location for RHPN2 Gene

32,978,592 bp from pter
33,064,918 bp from pter
86,327 bases
Minus strand

Genomic View for RHPN2 Gene

Genes around RHPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHPN2 Gene

Proteins for RHPN2 Gene

  • Protein details for RHPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RCG8
    • B3KUY8
    • B4DUS7
    • Q8N3T7
    • Q8N9D6
    • Q8NE33
    • Q96RU1

    Protein attributes for RHPN2 Gene

    686 amino acids
    Molecular mass:
    76993 Da
    Quaternary structure:
    • Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. According to PubMed:12473120, it does not interact with RhoA. Interacts with KRT18.

    Three dimensional structures from OCA and Proteopedia for RHPN2 Gene

    Alternative splice isoforms for RHPN2 Gene


neXtProt entry for RHPN2 Gene

Post-translational modifications for RHPN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHPN2 Gene

Domains & Families for RHPN2 Gene

Gene Families for RHPN2 Gene

Suggested Antigen Peptide Sequences for RHPN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RHPN family.
  • Belongs to the RHPN family.
genes like me logo Genes that share domains with RHPN2: view

Function for RHPN2 Gene

Molecular function for RHPN2 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.
UniProtKB/Swiss-Prot Induction:
By thyrotropin (TSH). Regulated by the cAMP pathway.
genes like me logo Genes that share phenotypes with RHPN2: view

Animal Models for RHPN2 Gene

MGI Knock Outs for RHPN2:

Animal Model Products

miRNA for RHPN2 Gene

miRTarBase miRNAs that target RHPN2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHPN2 Gene

Localization for RHPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHPN2 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHPN2 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for RHPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with RHPN2: view

Pathways & Interactions for RHPN2 Gene

genes like me logo Genes that share pathways with RHPN2: view

Pathways by source for RHPN2 Gene

1 GeneGo (Thomson Reuters) pathway for RHPN2 Gene
1 Qiagen pathway for RHPN2 Gene

Gene Ontology (GO) - Biological Process for RHPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RHPN2: view

No data available for SIGNOR curated interactions for RHPN2 Gene

Drugs & Compounds for RHPN2 Gene

(2) Drugs for RHPN2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHPN2: view

Transcripts for RHPN2 Gene

Unigene Clusters for RHPN2 Gene

Rhophilin, Rho GTPase binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHPN2 Gene

No ASD Table

Relevant External Links for RHPN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHPN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RHPN2 Gene

This gene is overexpressed in Salivary gland (22.5), Stomach (17.4), Islet of Langerhans (11.1), and Retina (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RHPN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RHPN2 Gene:


SOURCE GeneReport for Unigene cluster for RHPN2 Gene:


mRNA Expression by UniProt/SwissProt for RHPN2 Gene:

Tissue specificity: Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver.

Evidence on tissue expression from TISSUES for RHPN2 Gene

  • Nervous system(4.3)
  • Kidney(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with RHPN2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHPN2 Gene

Orthologs for RHPN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHPN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHPN2 34 35
  • 99.47 (n)
(Canis familiaris)
Mammalia RHPN2 34 35
  • 86.93 (n)
(Bos Taurus)
Mammalia RHPN2 34 35
  • 85.33 (n)
(Mus musculus)
Mammalia Rhpn2 34 16 35
  • 82.7 (n)
(Rattus norvegicus)
Mammalia Rhpn2 34
  • 82.65 (n)
(Monodelphis domestica)
Mammalia RHPN2 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia RHPN2 35
  • 78 (a)
(Gallus gallus)
Aves RHPN2 34 35
  • 68.88 (n)
(Anolis carolinensis)
Reptilia RHPN2 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhpn2 34
  • 62.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2712 34
(Danio rerio)
Actinopterygii rhpn2 34 35
  • 62.6 (n)
zgc55960 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000243 34
  • 54.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rhp 34 35
  • 51.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM20 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
Species where no ortholog for RHPN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHPN2 Gene

Gene Tree for RHPN2 (if available)
Gene Tree for RHPN2 (if available)

Paralogs for RHPN2 Gene

Paralogs for RHPN2 Gene

(2) SIMAP similar genes for RHPN2 Gene using alignment to 3 proteins: Pseudogenes for RHPN2 Gene

genes like me logo Genes that share paralogs with RHPN2: view

Variants for RHPN2 Gene

Sequence variations from dbSNP and Humsavar for RHPN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000061065 -- 33,058,705(+) AACCC(A/G)GGAGG intron-variant
rs1000155298 -- 33,043,130(+) CCAGC(G/T)ACTCA intron-variant
rs1000182262 -- 32,984,048(+) CTTCC(A/C)TCCTC intron-variant
rs1000202682 -- 33,019,052(+) AGAAA(A/G)AAAGA intron-variant
rs1000237503 -- 33,046,238(+) CTAGA(C/T)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHPN2 Gene

Variant ID Type Subtype PubMed ID
esv28223 CNV gain 19812545
nsv1058846 CNV loss 25217958
nsv1060014 CNV gain 25217958
nsv2462 CNV deletion 18451855
nsv828524 CNV gain 20364138
nsv833807 CNV loss 17160897
nsv9705 CNV gain 18304495
nsv978803 CNV duplication 23825009

Variation tolerance for RHPN2 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.95; 96.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHPN2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHPN2 Gene

Disorders for RHPN2 Gene

Relevant External Links for RHPN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RHPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHPN2 Gene

Publications for RHPN2 Gene

  1. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. (PMID: 12221077) Peck J.W. … Burbelo P.D. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Genetic heterogeneity in colorectal cancer associations between African and European americans. (PMID: 20659471) Kupfer S.S. … Ellis N.A. (Gastroenterology 2010) 3 46 64
  3. Association studies on 11 published colorectal cancer risk loci. (PMID: 20648012) von Holst S. … Lindblom A. (Br. J. Cancer 2010) 3 46 64
  4. Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype. (PMID: 20638935) AbulA- A. … Andreu M. (Gastroenterology 2010) 3 46 64
  5. Low-penetrance susceptibility variants in familial colorectal cancer. (PMID: 20501757) NiittymAoki I. … Aaltonen L.A. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64

Products for RHPN2 Gene

Sources for RHPN2 Gene

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