Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RHPN2 Gene

Aliases for RHPN2 Gene

  • Rhophilin, Rho GTPase Binding Protein 2 2 3
  • 76 KDa RhoB Effector Protein 3 4
  • GTP-Rho-Binding Protein 2 3 4
  • P76RBE 3 4
  • Rhophilin-Like Rho-GTPase Binding Protein 3
  • Rhophilin 2 3
  • Rhophilin-2 3
  • RHOBP 3

External Ids for RHPN2 Gene

Summaries for RHPN2 Gene

Entrez Gene Summary for RHPN2 Gene

  • This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]

GeneCards Summary for RHPN2 Gene

RHPN2 (Rhophilin, Rho GTPase Binding Protein 2) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex and G13 Signaling Pathway. An important paralog of this gene is RHPN1.

UniProtKB/Swiss-Prot for RHPN2 Gene

  • Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.

Gene Wiki entry for RHPN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHPN2 Gene

Genomics for RHPN2 Gene

Genomic Location for RHPN2 Gene

32,978,592 bp from pter
33,064,918 bp from pter
86,327 bases
Minus strand

Genomic View for RHPN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHPN2 Gene

Regulatory Elements for RHPN2 Gene

Proteins for RHPN2 Gene

  • Protein details for RHPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RCG8
    • B3KUY8
    • B4DUS7
    • Q8N3T7
    • Q8N9D6
    • Q8NE33
    • Q96RU1

    Protein attributes for RHPN2 Gene

    686 amino acids
    Molecular mass:
    76993 Da
    Quaternary structure:
    • Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. According to PubMed:12473120, it does not interact with RhoA. Interacts with KRT18.

    Three dimensional structures from OCA and Proteopedia for RHPN2 Gene

    Alternative splice isoforms for RHPN2 Gene


neXtProt entry for RHPN2 Gene

Proteomics data for RHPN2 Gene at MOPED

Post-translational modifications for RHPN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHPN2 Gene

Domains for RHPN2 Gene

Protein Domains for RHPN2 Gene


  • Contains 1 BRO1 domain.:
    • Q8IUC4
  • Contains 1 PDZ (DHR) domain.:
    • Q8IUC4
  • Belongs to the RHPN family.:
    • Q8IUC4
  • Contains 1 REM (Hr1) repeat.:
    • Q8IUC4
genes like me logo Genes that share domains with RHPN2: view

No data available for Gene Families for RHPN2 Gene

Function for RHPN2 Gene

Molecular function for RHPN2 Gene

UniProtKB/Swiss-Prot Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.
UniProtKB/Swiss-Prot Induction: By thyrotropin (TSH). Regulated by the cAMP pathway.

Gene Ontology (GO) - Molecular Function for RHPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RHPN2: view

Phenotypes for RHPN2 Gene

MGI mutant phenotypes for RHPN2:
inferred from 1 alleles
GenomeRNAi human phenotypes for RHPN2:
genes like me logo Genes that share phenotypes with RHPN2: view

Animal Models for RHPN2 Gene

MGI Knock Outs for RHPN2:

miRNA for RHPN2 Gene

miRTarBase miRNAs that target RHPN2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RHPN2 Gene

Localization for RHPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHPN2 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

Jensen Localization Image for RHPN2 Gene COMPARTMENTS Subcellular localization image for RHPN2 gene
Compartment Confidence
cytoskeleton 1
cytosol 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with RHPN2: view

Pathways for RHPN2 Gene

genes like me logo Genes that share pathways with RHPN2: view

Pathways by source for RHPN2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RHPN2 Gene
1 Qiagen pathway for RHPN2 Gene
1 BioSystems pathway for RHPN2 Gene

Gene Ontology (GO) - Biological Process for RHPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHPN2: view

Compounds for RHPN2 Gene

(2) HMDB Compounds for RHPN2 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with RHPN2: view

Transcripts for RHPN2 Gene

Unigene Clusters for RHPN2 Gene

Rhophilin, Rho GTPase binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHPN2 Gene

No ASD Table

Relevant External Links for RHPN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHPN2 Gene

mRNA expression in normal human tissues for RHPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHPN2 Gene

SOURCE GeneReport for Unigene cluster for RHPN2 Gene Hs.466435

mRNA Expression by UniProt/SwissProt for RHPN2 Gene

Tissue specificity: Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver.
genes like me logo Genes that share expressions with RHPN2: view

Orthologs for RHPN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHPN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHPN2 36
  • 99.47 (n)
  • 99.27 (a)
RHPN2 37
  • 99 (a)
(Bos Taurus)
Mammalia RHPN2 36
  • 85.33 (n)
  • 86.59 (a)
RHPN2 37
  • 87 (a)
(Canis familiaris)
Mammalia RHPN2 36
  • 86.93 (n)
  • 90.09 (a)
RHPN2 37
  • 87 (a)
(Mus musculus)
Mammalia Rhpn2 36
  • 82.7 (n)
  • 85.86 (a)
Rhpn2 16
Rhpn2 37
  • 86 (a)
(Monodelphis domestica)
Mammalia RHPN2 37
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia RHPN2 37
  • 78 (a)
(Rattus norvegicus)
Mammalia Rhpn2 36
  • 82.65 (n)
  • 85.13 (a)
(Gallus gallus)
Aves RHPN2 36
  • 68.88 (n)
  • 71.13 (a)
RHPN2 37
  • 70 (a)
(Anolis carolinensis)
Reptilia RHPN2 37
  • 59 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2712 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rhpn2 36
  • 62.41 (n)
  • 62.46 (a)
(Danio rerio)
Actinopterygii rhpn2 36
  • 62.6 (n)
  • 59.64 (a)
rhpn2 37
  • 59 (a)
zgc55960 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000243 36
  • 54.08 (n)
  • 45.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rhp 36
  • 51.25 (n)
  • 43.03 (a)
Rhp 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM20 37
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
Species with no ortholog for RHPN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHPN2 Gene

Gene Tree for RHPN2 (if available)
Gene Tree for RHPN2 (if available)

Paralogs for RHPN2 Gene

Paralogs for RHPN2 Gene

Selected SIMAP similar genes for RHPN2 Gene using alignment to 3 proteins: Pseudogenes for RHPN2 Gene

genes like me logo Genes that share paralogs with RHPN2: view

Variants for RHPN2 Gene

Sequence variations from dbSNP and Humsavar for RHPN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1559087 -- 33,060,135(+) CAGAC(A/G)CCTCA intron-variant
rs1559088 -- 33,060,155(+) TGTGA(C/T)Gtttt intron-variant
rs1974783 -- 33,060,601(+) gataa(C/G)agctc intron-variant
rs1974784 -- 33,060,657(+) cctcc(G/T)gagta intron-variant
rs2002181 -- 32,997,848(-) ctgct(A/G)ctctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHPN2 Gene

Variant ID Type Subtype PubMed ID
nsv833807 CNV Loss 17160897
esv28223 CNV Gain 19812545
nsv9705 CNV Gain 18304495
nsv828524 CNV Gain 20364138
nsv2462 CNV Loss 18451855

Relevant External Links for RHPN2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for RHPN2 Gene

Relevant External Links for RHPN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RHPN2: view

No data available for UniProtKB/Swiss-Prot for RHPN2 Gene

Publications for RHPN2 Gene

  1. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. (PMID: 12221077) Peck J.W. … Burbelo P.D. (J. Biol. Chem. 2002) 2 3 4 23
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 23
  3. Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP. (PMID: 12473120) Mircescu H. … Pirson I. (Eur. J. Biochem. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RHPN2 Gene

Sources for RHPN2 Gene

Back to Top