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RHPN2 Gene

protein-coding   GIFtS: 58
GCID: GC19M033469

Rhophilin, Rho GTPase Binding Protein 2

  Search for RHPN2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rhophilin, Rho GTPase Binding Protein 21 2     Rhophilin 22
76 KDa RhoB Effector Protein2 3     rhophilin-22
GTP-Rho-Binding Protein 22 3     Rhophilin-Like Rho-GTPase Binding Protein2
P76RBE2     p76RBE3
RHOBP2     

External Ids:    HGNC: 199741   Entrez Gene: 854152   Ensembl: ENSG000001319417   UniProtKB: Q8IUC43   

Export aliases for RHPN2 gene to outside databases

Previous GC identifers: GC19M033918 GC19M038145 GC19M038161 GC19M029972


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHPN2 Gene:
This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded
protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the
actin cytoskeleton. (provided by RefSeq, Apr 2009)

GeneCards Summary for RHPN2 Gene:
RHPN2 (rhophilin, Rho GTPase binding protein 2) is a protein-coding gene. An important paralog of this gene is PDCD6IP.

UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4
Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or
increase the turnover of F-actin structures in the absence of high levels of RhoA activity

Gene Wiki entry for RHPN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHPN2 gene promoter:
         Sox5   Pax-5   GR-beta   GCNF   LCR-F1   SRY   GCNF-1   GR-alpha   GCNF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHPN2 promoter sequence
   Search Chromatin IP Primers for RHPN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHPN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.12

RHPN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHPN2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M033469:  view genomic region     (about GC identifiers)

Start:
33,469,498 bp from pter      End:
33,555,824 bp from pter
Size:
86,327 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4 (See protein sequence)
Recommended Name: Rhophilin-2  
Size: 686 amino acids; 76993 Da
Subunit: Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. According to
PubMed:12473120, it does not interact with RhoA. Interacts with KRT18
1 PDB 3D structure from and Proteopedia for RHPN2:
2VSV (3D)    
Secondary accessions: B3KUY8 Q8N3T7 Q8N9D6 Q8NE33 Q96RU1

Explore the universe of human proteins at neXtProt for RHPN2: NX_Q8IUC4

Explore proteomics data for RHPN2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RHPN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149094.3  
    ENSEMBL proteins: 
     ENSP00000254260   ENSP00000465898   ENSP00000402244  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004328 BRO1_dom
     IPR001478 PDZ
     IPR011072 HR1_rho-bd

    Graphical View of Domain Structure for InterPro Entry Q8IUC4

    ProtoNet protein and cluster: Q8IUC4

    3 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB004328 BRO1-like domain
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4
    Similarity: Belongs to the RHPN family
    Similarity: Contains 1 BRO1 domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 REM (Hr1) repeat


    Find genes that share domains with RHPN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHPN2_HUMAN, Q8IUC4
    Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or
    increase the turnover of F-actin structures in the absence of high levels of RhoA activity
    Induction: By thyrotropin (TSH). Regulated by the cAMP pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RHPN2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RHPN2:
     G0/1 arrest  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rhpn2):
     normal 

    Find genes that share phenotypes with RHPN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rhpn2tm1Ssch for RHPN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHPN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHPN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHPN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHPN2

    miRNA
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    miRTarBase miRNAs that target RHPN2:
    hsa-mir-100-5p (MIRT048413), hsa-mir-32-5p (MIRT028291)

    Block miRNA regulation of human, mouse, rat RHPN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHPN2 (see all 32):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-3152-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidRHPN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHPN2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHPN2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHPN2_HUMAN, Q8IUC4: Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton1
    cytosol1
    endosome1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with RHPN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHPN2 About    
    See pathways by source

    SuperPathContained pathways About
    1Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35
    2G protein signaling RhoB regulation pathway
    G protein signaling RhoB regulation pathway
    3G13 Signaling Pathway
    G13 Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RHPN2
        RhoA Pathway

    1 GeneGo (Thomson Reuters) Pathway for RHPN2
        G-protein signaling RhoB regulation pathway

    1 BioSystems Pathway for RHPN2
        G13 Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHPN2
    Interactions:

        Search GeneGlobe Interaction Network for RHPN2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for RHPN2 (Q8IUC42, 3 ENSP000004022444) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3975242 I2D: score=2 
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    HLA-CP305043I2D: score=1 
    TGFBR1P368973I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--

    Find genes that share ontologies with RHPN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHPN2

    2 HMDB Compounds for RHPN2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHPN2 gene: 
    NM_033103.4  

    Unigene Cluster for RHPN2:

    Rhophilin, Rho GTPase binding protein 2
    Hs.466435  [show with all ESTs]
    Unigene Representative Sequence: AK126506
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000544458(uc002nue.3) ENST00000254260(uc002nuf.3 uc010xro.2)
    ENST00000588388 ENST00000588683 ENST00000592247 ENST00000591502 ENST00000585641
    ENST00000400226
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RHPN2 (see all 32):
    hsa-miR-2052 hsa-miR-4307 hsa-miR-3152-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidRHPN2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RHPN2
      QuantiFast Probe-based Assays in human, mouse, rat RHPN2

    Additional mRNA sequence: 

    AF268032.1 AF423421.1 AJ347750.1 AK026894.1 AK095001.1 AK098246.1 AK126506.1 AK300775.1 
    AK315105.1 AL831950.1 BC036447.2 

    7 DOTS entries:

    DT.75101237  DT.40117822  DT.100747243  DT.422285  DT.95373255  DT.95373256  DT.101966949 

    Selected AceView cDNA sequences (see all 78):

    AJ347750 BC036447 AA235454 AK026894 NM_033103 AI962973 BQ233061 BG259898 
    AA464079 AA463944 AI127133 AA464018 BE766635 AW513172 BM698463 AA464728 
    BU173824 BX382116 AW439625 CF141783 BU618709 AL831950 BE002823 AW439820 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHPN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGTATACA
    RHPN2 Expression
    About this image


    RHPN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
    RHPN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHPN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466435

    UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4
    Tissue specificity: Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas.
    Expressed at lower level in brain, spinal cord, kidney, placenta and liver

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHPN2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhpn21 , 5 rhophilin, Rho GTPase binding protein 21, 5 82.7(n)1
    85.86(a)1
      7 (21.36 cM)5
    524281  NM_027897.41  NP_082173.31 
     353341755 
    chicken
    (Gallus gallus)
    Aves RHPN21 rhophilin, Rho GTPase binding protein 2 68.88(n)
    71.13(a)
      415771  XM_414133.4  XP_414133.2 
    lizard
    (Anolis carolinensis)
    Reptilia RHPN26
    rhophilin, Rho GTPase binding protein 2
    59(a)
    1 ↔ 1
    GL343483.1(21236-51953)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.27122 Xenopus laevis transcribed sequence with moderate similarity more 74.12(n)    BQ385790.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559602 similar to rhophilin-2 75.54(n)   394153  BC044556.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rhp1 Rhophilin 51.25(n)
    43.03(a)
      32531  NM_078613.3  NP_511168.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RIM206
    Protein involved in proteolytic activation of Rim1...
    13(a)
    1 → many
    XV(839084-841069) YOR275C


    ENSEMBL Gene Tree for RHPN2 (if available)
    TreeFam Gene Tree for RHPN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHPN2 gene
    PDCD6IP2  PTPN232  RHPN12  
    2 SIMAP similar genes for RHPN2 using alignment to 3 protein entries:     RHPN2_HUMAN (see all proteins):
    RHPN2P1    RHPN1

    Find genes that share paralogs with RHPN2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RHPN2
    PGOHUM00000258803 PGOHUM00000259128


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHPN2 (see all 2060)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498330091,2
    Cuntested133512507(+) TCTTTC/TGTTTC 2 T syn11Minor allele frequency- T:0.00NA 4550
    rs713405151,2
    C--30000476(+) ATCTC-/ATAAATAA/
    ATAAATAAATAA
    ATAAA
    1 -- int11NA 2
    rs742573441,2
    C--33469015(+) GGCCAG/CGCACA 1 -- ds50014Minor allele frequency- C:0.16NA WA EA 360
    rs1410334271,2
    --33469034(+) CACCTA/GTAGTC 1 -- ds50010--------
    rs72518651,2
    C,A--33469168(+) tcatgT/Cctgta 1 -- ds50013Minor allele frequency- C:0.00NA CSA 4
    rs1825147381,2
    --33469329(+) AAAGAC/TACCAT 1 -- ds50010--------
    rs1871667851,2
    C--33469482(+) AAAGTA/CAAAAG 1 -- ds50010--------
    rs757705231,2
    C,F--33469527(+) AAATAT/CGTATA 1 -- ut313Minor allele frequency- C:0.05WA NA EA 358
    rs1903440731,2
    --33469551(+) AGGAGC/TAGCAG 1 -- ut310--------
    rs81097981,2
    C,F,A,H--33469577(+) GGTGGT/GTGCTT 1 -- ut3129Minor allele frequency- G:0.15NS EA NA WA CSA 3084

    HapMap Linkage Disequilibrium report for RHPN2 (33469498 - 33555824 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RHPN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2462CNV Loss18451855
    nsv833807CNV Loss17160897
    esv28223CNV Gain19812545
    nsv828524CNV Gain20364138
    nsv9705CNV Gain18304495

    Human Gene Mutation Database (HGMD): RHPN2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHPN2
    DNA2.0 Custom Variant and Variant Library Synthesis for RHPN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RHPN2           About GenesLikeMe

    Genetic Association Database (GAD): RHPN2
    Human Genome Epidemiology (HuGE) Navigator: RHPN2 (9 documents)

    Export disorders for RHPN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHPN2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with RHPN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. (PubMed id 12221077)1, 2, 3, 9 Peck J.W.... Burbelo P.D. (J. Biol. Chem. 2002)
    2. Genetic heterogeneity in colorectal cancer associations between African and European americans. (PubMed id 20659471)1, 4 Kupfer S.S....Ellis N.A. (Gastroenterology 2010)
    3. Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population. (PubMed id 20530476)1, 4 Xiong F....Lin D. (amp 2010)
    4. The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. (PubMed id 20437058)1, 4 Hawken S.J....Little J. (Hum. Genet. 2010)
    5. Association studies on 11 published colorectal cancer risk loci. (PubMed id 20648012)1, 4 von Holst S....Lindblom A. (Br. J. Cancer 2010)
    6. Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype. (PubMed id 20638935)1, 4 AbulA- A....Andreu M. (Gastroenterology 2010)
    7. Low-penetrance susceptibility variants in familial colorectal cancer. (PubMed id 20501757)1, 4 NiittymAoki I....Aaltonen L.A. (amp 2010)
    8. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. (PubMed id 19011631)1, 4 Houlston R.S....Dunlop M.G. (Nat. Genet. 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85415 HGNC: 19974 AceView: RHPN2 Ensembl:ENSG00000131941 euGenes: HUgn85415
    ECgene: RHPN2 H-InvDB: RHPN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHPN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHPN2 gene:
    Search GeneIP for patents involving RHPN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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