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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RHPN2 Gene

protein-coding GIFtS: 56
GCID: GC19M033469

rhophilin, Rho GTPase binding protein 2

Explore 5 diseases affiliated with
RHPN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rhophilin, Rho GTPase Binding Protein 2¹ ²		Rhophilin 2²
76 KDa RhoB Effector Protein² ³		Rhophilin-2¹
GTP-Rho-Binding Protein 2² ³		Rhophilin-Like Rho-GTPase Binding Protein²
P76RBE²		P76RBE²
RHOBP²

External Ids:	HGNC: 19974¹	Entrez Gene: 85415²	Ensembl: ENSG00000131941⁷	UniProtKB: Q8IUC4³

Export aliases for RHPN2 gene to outside databases

Previous GC identifers: GC19M033918 GC19M038145 GC19M038161 GC19M029972

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHPN2:

This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein

binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin

cytoskeleton. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4

Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase

the turnover of F-actin structures in the absence of high levels of RhoA activity

Gene Wiki entry for RHPN2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHPN2 gene promoter:
Sox5 Pax-5 GR-beta GCNF LCR-F1 SRY GCNF-1 GR-alpha GCNF-2 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHPN2 promoter sequence

Search SABiosciences Chromatin IP Primers for RHPN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHPN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.12

RHPN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHPN2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M033469: view genomic region (about GC identifiers)

Start:	33,469,498 bp from pter	End:	33,555,824 bp from pter
Size:	86,327 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4 (See protein sequence)

Recommended Name: Rhophilin-2

Size: 686 amino acids; 76993 Da

Subunit: Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. According to

PubMed:12473120, it does not interact with RhoA. Interacts with KRT18

Subcellular location: Cytoplasm, perinuclear region

1 PDB 3D structure from and Proteopedia for RHPN2:

2VSV (3D)

Secondary accessions: Q8N3T7 Q8N9D6 Q8NE33 Q96RU1

Explore the universe of human proteins at neXtProt for RHPN2: NX_Q8IUC4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IUC4

RHPN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_149094.3

ENSEMBL proteins:

ENSP00000439785 ENSP00000254260 ENSP00000465898 ENSP00000402244

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	Novus Biologicals RHPN2 Proteins Novus Biologicals RHPN2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RHPN2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0048471	perinuclear region of cytoplasm	IEA	--

RHPN2 for ontologies About GeneDecksing

RHPN2 Antibody Products:

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	Uscn ELISAs and CLIAs for RHPN2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RHPN2 for domains About GeneDecksing

3 InterPro domains/families:

IPR004328 BRO1_dom

IPR001478 PDZ

IPR011072 HR1_rho-bd

Graphical View of Domain Structure for InterPro Entry Q8IUC4

ProtoNet protein and cluster: Q8IUC4

3 Blocks protein families:

IPB001478 PDZ/DHR/GLGF domain

IPB004328 BRO1-like domain

IPB011072 Protein kinase PKN/PRK1

UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4

Similarity: Belongs to the RHPN family

Similarity: Contains 1 BRO1 domain

Similarity: Contains 1 PDZ (DHR) domain

Similarity: Contains 1 REM (Hr1) repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4

Function: Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase

the turnover of F-actin structures in the absence of high levels of RhoA activity

Induction: By thyrotropin (TSH). Regulated by the cAMP pathway

miRNA Products:		OriGene 3'-UTR Clone: RHPN2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHPN2
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RHPN2 (see all 32):
		hsa-miR-2052 hsa-miR-4307 hsa-miR-3152-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: RHPN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHPN2

2 GenomeRNAi human phenotypes for RHPN2:

G0/1 arrest

Increased G1 DNA content

Animal Models:
Mouse knock-out Rhpn2^tm1Ssch for RHPN2
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rhpn2):

normal

RHPN2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling_RhoA regulation pathway

G-protein signaling RhoB regulation pathway

0.16

G-protein signaling_RhoB regulation pathway

0.16

G13 Signaling Pathway

G13 Signaling Pathway

1.00

Actin Nucleation by ARP-WASP Complex

RhoA Pathway

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for RHPN2

G-protein signaling RhoB regulation pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for RHPN2

RhoA Pathway

1 GeneGo (Thomson Reuters) Pathway for RHPN2

G-protein signaling RhoB regulation pathway

1 BioSystems Pathway for RHPN2

G13 Signaling Pathway

RHPN2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RHPN2

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/23 Interacting proteins for RHPN2 (Q8IUC4^{2, 3} ENSP00000254260⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³	MINT-3975242 I2D: score=2
ENSG00000206435	P30504³	I2D: score=1
ENSG00000206452	P30504³	I2D: score=1
HLA-C	P30504³	I2D: score=1
RHOA	P61586³, ENSP00000400175⁴	I2D: score=2 STRING: ENSP00000400175

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--

RHPN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RHPN2

2 HMDB Compounds for RHPN2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about RHPN2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RHPN2 gene:

NM_033103.4

Unigene Cluster for RHPN2:

Rhophilin, Rho GTPase binding protein 2

Hs.466435 [show with all ESTs]

Unigene Representative Sequence: AK126506

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000544458(uc002nue.3) ENST00000254260(uc002nuf.3 uc010xro.2)

ENST00000588388 ENST00000588683 ENST00000592247 ENST00000591502 ENST00000585641

ENST00000400226

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHPN2
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RHPN2 (see all 32):
		hsa-miR-2052 hsa-miR-4307 hsa-miR-3152-3p hsa-miR-19b-2* hsa-miR-25 hsa-miR-200a hsa-miR-141 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: RHPN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: RHPN2 (NM_033103)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHPN2
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHPN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHPN2

Additional cDNA sequence:

AF268032.1 AF423421.1 AJ347750.1 AK026894.1 AK095001.1 AK098246.1 AK126506.1 AK300775.1

AK315105.1 AL831950.1 BC036447.2

7 DOTS entries:

DT.75101237 DT.40117822 DT.100747243 DT.422285 DT.95373255 DT.95373256 DT.101966949

24/78 AceView cDNA sequences (see all 78):

BM698463 BC036447 AI127133 AA463944 AA464079 BE766635 BU173824 AA235454

AJ347750 BG259898 BQ233061 AA464018 AK026894 BX382116 AI962973 NM_033103

AA464728 AW513172 CB215119 BE002823 BM791482 AI766193 BF196068 AF423421

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHPN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTGTATACA

About this image

RHPN2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RHPN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHPN2

SOURCE GeneReport for Unigene cluster: Hs.466435

UniProtKB/Swiss-Prot: RHPN2_HUMAN, Q8IUC4

Tissue specificity: Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas.

Expressed at lower level in brain, spinal cord, kidney, placenta and liver

SABiosciences Custom PCR Arrays for RHPN2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHPN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHPN2 gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rhpn2^{1 , 5}	rhophilin, Rho GTPase binding protein 2^{1, 5}	82.7(n)¹ 85.86(a)¹		7 (21.36 cM)⁵ 52428¹ NM_027897.4¹ NP_082173.3¹ 35334175⁵
chicken (Gallus gallus)	Aves	RHPN2¹	rhophilin, Rho GTPase binding protein 2	69.42(n) 71.72(a)		415771 XM_414133.3 XP_414133.2
lizard (Anolis carolinensis)	Reptilia	RHPN2⁶	--	60(a)	1 ↔ 1	GL343483.1(21440-51953)
African clawed frog (Xenopus laevis)	Amphibia	Xl.2712²	Xenopus laevis transcribed sequence with moderate similarity more	74.12(n)		BQ385790.1
zebrafish (Danio rerio)	Actinopterygii	zgc55960²	similar to rhophilin-2	75.54(n)		394153 BC044556.1
fruit fly (Drosophila melanogaster)	Insecta	Rhp⁶	Rhophilin	34(a)	1 → many	X(15682926-15687780)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G15130⁶	programmed cell death 6-interacting protein	13(a)	1 → many	1(5206002-5209915)
rice (Oryza sativa)	Liliopsida	-- --	vacuolar protein-sorting protein bro1, putative, e... vacuolar protein-sorting protein bro1, putative, e...	20(a) 12(a)	many ↔ many many ↔ many	2(25586057-25589280) 10(18766286-18771760)

ENSEMBL Gene Tree for RHPN2 (if available)
TreeFam Gene Tree for RHPN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RHPN2 gene

RHPN1²

2 SIMAP similar genes for RHPN2 using alignment to 4 protein entries: RHPN2_HUMAN (see all proteins):

RHPN2P1 RHPN1

RHPN2 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for RHPN2
PGOHUM00000258803 PGOHUM00000259128

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149833009^1,2	C	other	33512507(+)	`TCTTTC/TGTTTC`	2	T	syn¹		1		NA	4550
rs34594918^1,2	C,F,	--	30014701(+)	`AGCCC-/AAGCTC`	1	--	int¹		5		NA CSA	10
rs74257344^1,2	C,	--	33469015(+)	`GGCCAG/CGCACA`	1	--	ds500¹		4		NA WA EA	360
rs141033427^1,2		--	33469034(+)	`CACCTA/GTAGTC`	1	--	ds500¹		0	--	--	--	--
rs7251865^1,2	C,A,	--	33469168(+)	`TCATGT/CCTGTA`	1	--	ds500¹		3		NA CSA	4
rs182514738^1,2		--	33469329(+)	`AAAGAC/TACCAT`	1	--	ds500¹		0	--	--	--	--
rs187166785^1,2		--	33469482(+)	`AAAGTA/CAAAAG`	1	--	ds500¹		0	--	--	--	--
rs75770523^1,2	F,	--	33469527(+)	`AAATAT/CGTATA`	1	--	ut3¹		3		WA NA EA	358
rs190344073^1,2		--	33469551(+)	`AGGAGC/TAGCAG`	1	--	ut3¹		0	--	--	--	--
rs8109798^1,2	C,F,A,H,	--	33469577(+)	`GGTGGT/GTGCTT`	1	--	ut3¹		29		NS EA NA WA CSA	3084

HapMap Linkage Disequilibrium report for RHPN2 (33469498 - 33555824 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for RHPN2
4 CNVs: 78166 73356 89200 89199
1 Indel: 33323
Human Gene Mutation Database (HGMD): RHPN2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHPN2

DNA2.0 Custom Variant and Variant Library Synthesis for RHPN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RHPN2 for disorders About GeneDecksing

5 diseases for RHPN2: About MalaCards

pituitary adenoma adenoma colorectal cancer thyroiditis

prostatitis

Human Genome Epidemiology (HuGE) Navigator: RHPN2 (9 documents)

Export disorders for RHPN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RHPN2 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with RHPN2)

Utopia: connect your pdf to the dynamic
world of online information

The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. (PubMed id 12221077)^{1, 2, 3, 9} Peck J.W.... Burbelo P.D. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP. (PubMed id 12473120)^{1, 2} Mircescu H.... Pirson I. (2002)
Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PubMed id 16777052)^{1, 9} Zhan X. and Desiderio D.M. (2006)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Genetic heterogeneity in colorectal cancer associatio ns between African and European americans. (PubMed id 20659471)¹ Kupfer S.S....Ellis N.A. (2010)
Generalizability and Epidemiologic Characterization o f Eleven Colorectal Cancer GWAS Hits in Multiple Populations. (PubMed id 21071539)¹ He J....Haiman C.A. (2010)
Risk of genome-wide association study-identified gene tic variants for colorectal cancer in a Chinese population. (PubMed id 20530476)¹ Xiong F....Lin D. (2010)
The utility and predictive value of combinations of l ow penetrance genes for screening and risk prediction of colorectal cancer. (PubMed id 20437058)¹ Hawken S.J....Little J. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 85415	HGNC: 19974	AceView: RHPN2	Ensembl:ENSG00000131941	euGenes: HUgn85415
ECgene: RHPN2	H-InvDB: RHPN2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RHPN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RHPN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RHPN2 gene:
Search GeneIP for patents involving RHPN2

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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RHPN2 Gene

rhophilin, Rho GTPase binding protein 2

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RHPN2 Gene

rhophilin, Rho GTPase binding protein 2

Aliasesfor RHPN2 gene

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Genomic Viewsfor RHPN2 gene

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Protein Domains /Familiesfor RHPN2 gene

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for RHPN2 gene

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for RHPN2 gene

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for RHPN2 gene

Pathways & Interactions
for RHPN2 gene

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for RHPN2 gene

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for RHPN2 gene

Expression
for RHPN2 gene

Orthologs
for RHPN2 gene

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for RHPN2 gene

Genomic Variants
for RHPN2 gene

Disorders / Diseases
for RHPN2 gene

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for RHPN2 gene

Intellectual Property
for RHPN2 gene

Products
for RHPN2 gene