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Aliases for RHPN2 Gene

Aliases for RHPN2 Gene

  • Rhophilin, Rho GTPase Binding Protein 2 2 3 5
  • 76 KDa RhoB Effector Protein 3 4
  • GTP-Rho-Binding Protein 2 3 4
  • P76RBE 3 4
  • Rhophilin-Like Rho-GTPase Binding Protein 3
  • Rhophilin 2 3
  • RHOBP 3

External Ids for RHPN2 Gene

Previous GeneCards Identifiers for RHPN2 Gene

  • GC19M033918
  • GC19M038145
  • GC19M038161
  • GC19M033469
  • GC19M029972

Summaries for RHPN2 Gene

Entrez Gene Summary for RHPN2 Gene

  • This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]

GeneCards Summary for RHPN2 Gene

RHPN2 (Rhophilin, Rho GTPase Binding Protein 2) is a Protein Coding gene. Among its related pathways are RHO GTPases Activate Rhotekin and Rhophilins and Signaling by Rho GTPases. An important paralog of this gene is RHPN1.

UniProtKB/Swiss-Prot for RHPN2 Gene

  • Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.

Gene Wiki entry for RHPN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHPN2 Gene

Genomics for RHPN2 Gene

Regulatory Elements for RHPN2 Gene

Enhancers for RHPN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RHPN2 on UCSC Golden Path with GeneCards custom track

Promoters for RHPN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHPN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RHPN2 Gene

32,978,592 bp from pter
33,064,918 bp from pter
86,327 bases
Minus strand

Genomic View for RHPN2 Gene

Genes around RHPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHPN2 Gene

Proteins for RHPN2 Gene

  • Protein details for RHPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RCG8
    • B3KUY8
    • B4DUS7
    • Q8N3T7
    • Q8N9D6
    • Q8NE33
    • Q96RU1

    Protein attributes for RHPN2 Gene

    686 amino acids
    Molecular mass:
    76993 Da
    Quaternary structure:
    • Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. According to PubMed:12473120, it does not interact with RhoA. Interacts with KRT18.

    Three dimensional structures from OCA and Proteopedia for RHPN2 Gene

    Alternative splice isoforms for RHPN2 Gene


neXtProt entry for RHPN2 Gene

Proteomics data for RHPN2 Gene at MOPED

Post-translational modifications for RHPN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHPN2 Gene

Domains & Families for RHPN2 Gene

Gene Families for RHPN2 Gene

Protein Domains for RHPN2 Gene

Suggested Antigen Peptide Sequences for RHPN2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BRO1 domain.
  • Belongs to the RHPN family.
  • Contains 1 REM (Hr1) repeat.
  • Contains 1 BRO1 domain.
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the RHPN family.
  • Contains 1 REM (Hr1) repeat.
genes like me logo Genes that share domains with RHPN2: view

Function for RHPN2 Gene

Molecular function for RHPN2 Gene

UniProtKB/Swiss-Prot Function:
Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.
UniProtKB/Swiss-Prot Induction:
By thyrotropin (TSH). Regulated by the cAMP pathway.
genes like me logo Genes that share phenotypes with RHPN2: view

Animal Models for RHPN2 Gene

MGI Knock Outs for RHPN2:

Animal Model Products

miRNA for RHPN2 Gene

miRTarBase miRNAs that target RHPN2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHPN2 Gene

Localization for RHPN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHPN2 Gene

Cytoplasm, perinuclear region.

Subcellular locations from

Jensen Localization Image for RHPN2 Gene COMPARTMENTS Subcellular localization image for RHPN2 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with RHPN2: view

Pathways & Interactions for RHPN2 Gene

genes like me logo Genes that share pathways with RHPN2: view

Pathways by source for RHPN2 Gene

1 GeneGo (Thomson Reuters) pathway for RHPN2 Gene
1 Qiagen pathway for RHPN2 Gene

Gene Ontology (GO) - Biological Process for RHPN2 Gene


No data available for SIGNOR curated interactions for RHPN2 Gene

Drugs & Compounds for RHPN2 Gene

(2) Drugs for RHPN2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHPN2: view

Transcripts for RHPN2 Gene

Unigene Clusters for RHPN2 Gene

Rhophilin, Rho GTPase binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHPN2 Gene

No ASD Table

Relevant External Links for RHPN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHPN2 Gene

mRNA expression in normal human tissues for RHPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RHPN2 Gene

This gene is overexpressed in Salivary gland (22.5), Stomach (17.4), Islet of Langerhans (11.1), and Retina (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHPN2 Gene

SOURCE GeneReport for Unigene cluster for RHPN2 Gene Hs.466435

mRNA Expression by UniProt/SwissProt for RHPN2 Gene

Tissue specificity: Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver.
genes like me logo Genes that share expression patterns with RHPN2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for RHPN2 Gene

Orthologs for RHPN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHPN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RHPN2 35
  • 85.33 (n)
  • 86.59 (a)
RHPN2 36
  • 87 (a)
(Canis familiaris)
Mammalia RHPN2 35
  • 86.93 (n)
  • 90.09 (a)
RHPN2 36
  • 87 (a)
(Mus musculus)
Mammalia Rhpn2 35
  • 82.7 (n)
  • 85.86 (a)
Rhpn2 16
Rhpn2 36
  • 86 (a)
(Pan troglodytes)
Mammalia RHPN2 35
  • 99.47 (n)
  • 99.27 (a)
RHPN2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rhpn2 35
  • 82.65 (n)
  • 85.13 (a)
(Monodelphis domestica)
Mammalia RHPN2 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia RHPN2 36
  • 78 (a)
(Gallus gallus)
Aves RHPN2 35
  • 68.88 (n)
  • 71.13 (a)
RHPN2 36
  • 70 (a)
(Anolis carolinensis)
Reptilia RHPN2 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhpn2 35
  • 62.41 (n)
  • 62.46 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2712 35
(Danio rerio)
Actinopterygii rhpn2 35
  • 62.6 (n)
  • 59.64 (a)
zgc55960 35
rhpn2 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000243 35
  • 54.08 (n)
  • 45.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rhp 35
  • 51.25 (n)
  • 43.03 (a)
Rhp 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM20 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for RHPN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHPN2 Gene

Gene Tree for RHPN2 (if available)
Gene Tree for RHPN2 (if available)

Paralogs for RHPN2 Gene

Paralogs for RHPN2 Gene

(2) SIMAP similar genes for RHPN2 Gene using alignment to 3 proteins: Pseudogenes for RHPN2 Gene

genes like me logo Genes that share paralogs with RHPN2: view

Variants for RHPN2 Gene

Sequence variations from dbSNP and Humsavar for RHPN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs28626308 - 33,026,609(+) GCTCC(C/T)GCACC reference, missense
rs28407794 - 33,002,328(+) GCTGG(C/G)CCAGG reference, missense
rs7256649 -- 33,051,323(+) CTTAC(A/G)TGCCC intron-variant
rs7257471 -- 32,988,215(+) aacaa(A/C)aaaaa intron-variant
rs7257754 -- 33,011,350(+) ATCTG(A/G)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHPN2 Gene

Variant ID Type Subtype PubMed ID
nsv833807 CNV Loss 17160897
esv28223 CNV Gain 19812545
nsv9705 CNV Gain 18304495
nsv828524 CNV Gain 20364138
nsv2462 CNV Loss 18451855

Variation tolerance for RHPN2 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.95; 96.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHPN2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHPN2 Gene

Disorders for RHPN2 Gene

Relevant External Links for RHPN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RHPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHPN2 Gene

Publications for RHPN2 Gene

  1. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. (PMID: 12221077) Peck J.W. … Burbelo P.D. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X. … Desiderio D.M. (Anal. Biochem. 2006) 3 23
  3. Association between GWAS-identified genetic variations and disease prognosis for patients with colorectal cancer. (PMID: 25799222) Kang B.W. … Kim J.G. (PLoS ONE 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. (PMID: 24737748) Whiffin N. … Dunlop M.G. (Hum. Mol. Genet. 2014) 3

Products for RHPN2 Gene

Sources for RHPN2 Gene