Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RHPN1 Gene

Aliases for RHPN1 Gene

  • Rhophilin, Rho GTPase Binding Protein 1 2 3
  • GTP-Rho-Binding Protein 1 3 4
  • Outer Dense Fiber Of Sperm Tails 5 3
  • Rhophilin 1 3
  • Rhophilin-1 3
  • RHOPHILIN 3
  • KIAA1929 4
  • ODF5 3
  • RHPN 3

External Ids for RHPN1 Gene

Previous GeneCards Identifiers for RHPN1 Gene

  • GC08P144654
  • GC08P144226
  • GC08P144556
  • GC08P144522
  • GC08P139704
  • GC08P144451

Summaries for RHPN1 Gene

GeneCards Summary for RHPN1 Gene

RHPN1 (Rhophilin, Rho GTPase Binding Protein 1) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex and G-protein signaling_RhoA regulation pathway. An important paralog of this gene is PDCD6IP.

UniProtKB/Swiss-Prot for RHPN1 Gene

  • Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity).

Gene Wiki entry for RHPN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHPN1 Gene

Genomics for RHPN1 Gene

Regulatory Elements for RHPN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RHPN1 Gene

Start:
143,368,855 bp from pter
End:
143,384,220 bp from pter
Size:
15,366 bases
Orientation:
Plus strand

Genomic View for RHPN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHPN1 Gene

Proteins for RHPN1 Gene

  • Protein details for RHPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCX5-RHPN1_HUMAN
    Recommended name:
    Rhophilin-1
    Protein Accession:
    Q8TCX5
    Secondary Accessions:
    • Q8TAV1
    • Q96PV9

    Protein attributes for RHPN1 Gene

    Size:
    695 amino acids
    Molecular mass:
    76292 Da
    Quaternary structure:
    • Binds specifically to GTP-Rho. Interacts with ROPN1 (By similarity).
    SequenceCaution:
    • Sequence=BAB67822.1; Type=Frameshift; Positions=386; Evidence={ECO:0000305};

    Alternative splice isoforms for RHPN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHPN1 Gene

Proteomics data for RHPN1 Gene at MOPED

Post-translational modifications for RHPN1 Gene

  • Ubiquitination at Lys213
  • Modification sites at PhosphoSitePlus

Other Protein References for RHPN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHPN1 Gene

Domains for RHPN1 Gene

Protein Domains for RHPN1 Gene

Suggested Antigen Peptide Sequences for RHPN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCX5

UniProtKB/Swiss-Prot:

RHPN1_HUMAN :
  • Q8TCX5
Domain:
  • The PDZ domain mediates interaction with ROPN1.
  • Contains 1 BRO1 domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the RHPN family.
Similarity:
  • Contains 1 REM (Hr1) repeat.
genes like me logo Genes that share domains with RHPN1: view

No data available for Gene Families for RHPN1 Gene

Function for RHPN1 Gene

Molecular function for RHPN1 Gene

UniProtKB/Swiss-Prot Function: Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity).

Gene Ontology (GO) - Molecular Function for RHPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RHPN1: view

Animal Model Products

miRNA for RHPN1 Gene

miRTarBase miRNAs that target RHPN1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RHPN1 Gene

Localization for RHPN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHPN1 Gene COMPARTMENTS Subcellular localization image for RHPN1 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RHPN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RHPN1 Gene

Pathways for RHPN1 Gene

genes like me logo Genes that share pathways with RHPN1: view

Pathways by source for RHPN1 Gene

1 Qiagen pathway for RHPN1 Gene
1 GeneGo (Thomson Reuters) pathway for RHPN1 Gene

Gene Ontology (GO) - Biological Process for RHPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with RHPN1: view

Compounds for RHPN1 Gene

(1) HMDB Compounds for RHPN1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RHPN1: view

Transcripts for RHPN1 Gene

Unigene Clusters for RHPN1 Gene

Rhophilin, Rho GTPase binding protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RHPN1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RHPN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHPN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ^
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: - - -
SP6:
SP7: - - -
SP8: -
SP9:
SP10: -
SP11:
SP12:

ExUns: 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for RHPN1 Gene

GeneLoc Exon Structure for
RHPN1
ECgene alternative splicing isoforms for
RHPN1

Expression for RHPN1 Gene

mRNA expression in normal human tissues for RHPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHPN1 Gene

This gene is overexpressed in Pituitary (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RHPN1 Gene

SOURCE GeneReport for Unigene cluster for RHPN1 Gene Hs.521912

genes like me logo Genes that share expressions with RHPN1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RHPN1 Gene

Orthologs for RHPN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHPN1 35
  • 98.96 (n)
  • 98.89 (a)
RHPN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHPN1 35
  • 81.42 (n)
  • 75.08 (a)
RHPN1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHPN1 35
  • 81.22 (n)
  • 75.77 (a)
RHPN1 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhpn1 35
  • 79.31 (n)
  • 74.61 (a)
Rhpn1 16
Rhpn1 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHPN1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHPN1 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhpn1 35
  • 78.28 (n)
  • 73.53 (a)
chicken
(Gallus gallus)
Aves RHPN1 35
  • 67.51 (n)
  • 60.03 (a)
RHPN1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHPN1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhpn1 35
  • 64.25 (n)
  • 58.55 (a)
Str.15860 35
zebrafish
(Danio rerio)
Actinopterygii rhpn1 35
  • 61.12 (n)
  • 57.79 (a)
rhpn1 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rhp 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RIM20 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for RHPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHPN1 Gene

ENSEMBL:
Gene Tree for RHPN1 (if available)
TreeFam:
Gene Tree for RHPN1 (if available)

Paralogs for RHPN1 Gene

Paralogs for RHPN1 Gene

Selected SIMAP similar genes for RHPN1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RHPN1 Gene

genes like me logo Genes that share paralogs with RHPN1: view

Variants for RHPN1 Gene

Sequence variations from dbSNP and Humsavar for RHPN1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs901760 -- 143,377,159(+) GCGCG(C/T)GCATG intron-variant
rs901761 -- 143,377,384(+) GCGAA(G/T)CTGTC reference, missense
rs901762 -- 143,378,399(+) CATGC(A/G)GAGGC intron-variant
rs1055181 -- 143,384,035(+) AGAGA(C/T)GCAGG utr-variant-3-prime
rs1064194 -- 143,382,719(+) TCCCC(A/C)CCCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RHPN1 Gene

Variant ID Type Subtype PubMed ID
dgv7920n71 CNV Loss 21882294
dgv7921n71 CNV Loss 21882294
dgv7922n71 CNV Loss 21882294
nsv891671 CNV Loss 21882294
nsv470247 CNV Loss 18288195
nsv891674 CNV Loss 21882294
nsv891675 CNV Loss 21882294
nsv891676 CNV Loss 21882294
nsv891677 CNV Loss 21882294
nsv891678 CNV Gain 21882294
dgv7924n71 CNV Loss 21882294
dgv7925n71 CNV Loss 21882294
nsv891682 CNV Loss 21882294
nsv891685 CNV Loss 21882294
esv28774 CNV Loss 19812545
esv2738005 CNV Deletion 23290073
nsv397650 CNV Insertion 16902084
esv2927 CNV Deletion 18987735

Relevant External Links for RHPN1 Gene

HapMap Linkage Disequilibrium report
RHPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHPN1 Gene

Disorders for RHPN1 Gene

No disorders were found for RHPN1 Gene.

No data available for UniProtKB/Swiss-Prot for RHPN1 Gene

Publications for RHPN1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. (PMID: 12221077) Peck J.W. … Burbelo P.D. (J. Biol. Chem. 2002) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production. (PMID: 19403673) Popov S. … GAPttlinger H.G. (J. Virol. 2009) 3

Products for RHPN1 Gene

Sources for RHPN1 Gene

Back to Top

Content