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RHPN1 Gene

protein-coding   GIFtS: 54
GCID: GC08P144451

Rhophilin, Rho GTPase Binding Protein 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rhophilin, Rho GTPase Binding Protein 11 2     Outer Dense Fiber Of Sperm Tails 52
GTP-Rho-Binding Protein 12 3     Rhophilin 12
ODF52     rhophilin-12
RHOPHILIN2     KIAA19293
RHPN2     

External Ids:    HGNC: 199731   Entrez Gene: 1148222   Ensembl: ENSG000001581067   OMIM: 6010315   UniProtKB: Q8TCX53   

Export aliases for RHPN1 gene to outside databases

Previous GC identifers: GC08P144654 GC08P144226 GC08P144556 GC08P144522 GC08P139704


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHPN1 Gene:
RHPN1 (rhophilin, Rho GTPase binding protein 1) is a protein-coding gene. Diseases associated with RHPN1 include malaria. GO annotations related to this gene include small GTPase regulator activity. An important paralog of this gene is PDCD6IP.

UniProtKB/Swiss-Prot: RHPN1_HUMAN, Q8TCX5
Function: Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component
upon Rho binding or relay a Rho signal to other molecules (By similarity)

Gene Wiki entry for RHPN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHPN1 gene promoter:
         C/EBPbeta   NRSF form 1   Lmo2   Pax-2   Pax-2a   IRF-1   NRSF form 2   IRF-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHPN1 promoter sequence
   Search Chromatin IP Primers for RHPN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHPN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

RHPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHPN1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P144451:  view genomic region     (about GC identifiers)

Start:
144,451,025 bp from pter      End:
144,466,390 bp from pter
Size:
15,366 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RHPN1_HUMAN, Q8TCX5 (See protein sequence)
Recommended Name: Rhophilin-1  
Size: 695 amino acids; 76292 Da
Subunit: Binds specifically to GTP-Rho. Interacts with ROPN1 (By similarity)
Sequence caution: Sequence=BAB67822.1; Type=Frameshift; Positions=386;
Secondary accessions: Q8TAV1 Q96PV9
Alternative splicing: 2 isoforms:  Q8TCX5-1   Q8TCX5-2   (May be due to intron retention)

Explore the universe of human proteins at neXtProt for RHPN1: NX_Q8TCX5

Explore proteomics data for RHPN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys213
  • Modification sites at PhosphoSitePlus

  • See RHPN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_443156.2  
    ENSEMBL proteins: 
     ENSP00000289013  

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    Cloud-Clone Corp. CLIAs for RHPN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004328 BRO1_dom
     IPR001478 PDZ
     IPR011072 HR1_rho-bd

    Graphical View of Domain Structure for InterPro Entry Q8TCX5

    ProtoNet protein and cluster: Q8TCX5

    3 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB004328 BRO1-like domain
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: RHPN1_HUMAN, Q8TCX5
    Domain: The PDZ domain mediates interaction with ROPN1 (By similarity)
    Similarity: Belongs to the RHPN family
    Similarity: Contains 1 BRO1 domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 REM (Hr1) repeat


    RHPN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHPN1_HUMAN, Q8TCX5
    Function: Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component
    upon Rho binding or relay a Rho signal to other molecules (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity IEA--
    GO:0005515protein binding ----
         
    RHPN1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHPN1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHPN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHPN1

    miRNA
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    miRTarBase miRNAs that target RHPN1:
    hsa-mir-18a-3p (MIRT040941)

    Block miRNA regulation of human, mouse, rat RHPN1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RHPN1:
    hsa-miR-4328 hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidRHPN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHPN1

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHPN1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHPN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    golgi apparatus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHPN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35
    2G protein signaling RhoA regulation pathway
    G protein signaling RhoA regulation pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RHPN1
        RhoA Pathway

    1 GeneGo (Thomson Reuters) Pathway for RHPN1
        G-protein signaling RhoA regulation pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RHPN1
    Interactions:

        GeneGlobe Interaction Network for RHPN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for RHPN1 (Q8TCX52, 3 ENSP000002890134) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-67814 I2D: score=4 STRING: ENSP00000254043
    TRIM37O949722, 3, ENSP000002622944MINT-66825 I2D: score=4 STRING: ENSP00000262294
    EFEMP2O959672, 3, ENSP000003099534MINT-68060 I2D: score=3 STRING: ENSP00000309953
    CALCOCO2Q131372, 3, ENSP000002589474MINT-68137 I2D: score=4 STRING: ENSP00000258947
    RHOAP615863, ENSP000004001754I2D: score=1 STRING: ENSP00000400175
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--

    RHPN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHPN1

    1 HMDB Compound for RHPN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RHPN1 gene: 
    NM_052924.2  

    Unigene Cluster for RHPN1:

    Rhophilin, Rho GTPase binding protein 1
    Hs.521912  [show with all ESTs]
    Unigene Representative Sequence: NM_052924
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289013(uc003yyb.3) ENST00000522335 ENST00000522899
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate RHPN1:
    hsa-miR-4328 hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidRHPN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHPN1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHPN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHPN1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RHPN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHPN1
      QuantiTect SYBR Green Assays in human, mouse, rat RHPN1
      QuantiFast Probe-based Assays in human, mouse, rat RHPN1

    Additional mRNA sequence: 

    BC012135.1 BC025767.1 

    8 DOTS entries:

    DT.97842691  DT.107245  DT.92418269  DT.97842690  DT.92015047  DT.100779721  DT.91684965  DT.120630165 

    Selected AceView cDNA sequences (see all 95):

    CB851722 CB216237 NM_052924 BM743041 CD513476 BU171128 CR612945 BC025767 
    AY082588 BM836003 BQ927119 BQ944101 BM836260 BQ880416 CA432432 BQ072325 
    BM747734 CA396768 BE251330 CA393039 AI469291 BX096110 BX384556 BM681595 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RHPN1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ^
    SP1:                                                              -           -                                                                 -               
    SP2:                                                              -           -                                                                 -               
    SP3:                                -                             -           -                       -     -                                                   
    SP4:                                                              -                                                                                             
    SP5:                                                              -     -     -                                                                                 

    ExUns: 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -                           
    SP2:              -                           
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for RHPN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHPN1 expression in normal human tissues (normalized intensities)      RHPN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGTCTCCC
    RHPN1 Expression
    About this image


    RHPN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Metanephros
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RHPN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHPN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521912
        Custom PCR Arrays for RHPN1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHPN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RHPN1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhpn11 , 5 rhophilin, Rho GTPase binding protein 11, 5 79.31(n)1
    74.61(a)1
      15 (34.76 cM)5
    147871  NM_001163465.11  NP_001156937.11 
     757042805 
    chicken
    (Gallus gallus)
    Aves RHPN11 rhophilin, Rho GTPase binding protein 1 67.51(n)
    60.03(a)
      420299  XM_418410.4  XP_418410.3 
    lizard
    (Anolis carolinensis)
    Reptilia RHPN16
    rhophilin, Rho GTPase binding protein 1
    58(a)
    1 ↔ 1
    GL343511.1(504011-543695)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.158602 Transcribed sequence with weak similarity to protein more 74.8(n)    142031152 
    zebrafish
    (Danio rerio)
    Actinopterygii rhpn11 rhophilin, Rho GTPase binding protein 1 61.12(n)
    57.79(a)
      100537370  XM_003200777.2  XP_003200825.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rhp6
    Rhophilin
    33(a)
    1 → many
    X(15682926-15687780)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RIM206
    Protein involved in proteolytic activation of Rim1...
    13(a)
    1 → many
    XV(839084-841069) YOR275C


    ENSEMBL Gene Tree for RHPN1 (if available)
    TreeFam Gene Tree for RHPN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHPN1 gene
    PDCD6IP2  RHPN22  PTPN232  
    2 SIMAP similar genes for RHPN1 using alignment to 1 protein entry:     RHPN1_HUMAN:
    RHPN2    RHPN2P1

    RHPN1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RHPN1
    PGOHUM00000258804 PGOHUM00000259127


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHPN1 (see all 507)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733658491,2
    C,F--144453024(+) CAGAAG/AGTTCT 1 -- int12Minor allele frequency- A:0.05WA 120
    rs1467703451,2
    --144453175(+) CTGGCG/TGGACA 1 -- int10--------
    rs24678981,2
    C,F,H--144453316(+) CTGCCG/ATGAGT 1 -- int114Minor allele frequency- A:0.26NS EA NA WA CSA 1422
    rs715205131,2
    C,F--144453351(+) TGCGTG/ACTGCT 1 -- int16Minor allele frequency- A:0.07NA WA EA 364
    rs1873083001,2
    --144453361(+) TTATAG/TCCCTG 1 -- int10--------
    rs1918288951,2
    --144453650(+) GATCCC/TGGGGG 1 -- int10--------
    rs1836789981,2
    --144453742(+) CCCAGG/TTCAGC 1 -- int10--------
    rs1867959851,2
    --144453985(+) TCCAGA/GTCACC 1 -- int10--------
    rs1930155811,2
    --144453995(+) CTTTGC/TCTCCA 1 -- int10--------
    rs352635741,2
    C--144454090(+) TGGAAA/GGTGGG 1 -- int14Minor allele frequency- G:0.07NA WA EA 360

    HapMap Linkage Disequilibrium report for RHPN1 (144451025 - 144466390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RHPN1 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2927CNV Deletion18987735
    esv2738005CNV Deletion23290073
    nsv397650CNV Insertion16902084
    dgv7921n71CNV Loss21882294
    dgv7920n71CNV Loss21882294
    nsv891682CNV Loss21882294
    dgv7924n71CNV Loss21882294
    esv28774CNV Loss19812545
    dgv7925n71CNV Loss21882294
    nsv891675CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601031    OMIM disorders: --

    1 disease for RHPN1:    About MalaCards
    malaria


    RHPN1 for disorders           About GeneDecksing


    Export disorders for RHPN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHPN1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RHPN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization. (PubMed id 12221077)1, 9 Peck J.W.... Burbelo P.D. (J. Biol. Chem. 2002)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Divergent Bro1 domains share the capacity to bind human immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particle production. (PubMed id 19403673)1 Popov S....GAPttlinger H.G. (J. Virol. 2009)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    7. Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. (PubMed id 14749388)1 Jaffe A.B.... Hall A. (Mol. Cell. Biol. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PubMed id 10591629)1 Fujita A....Narumiya S. (J. Cell. Sci. 2000)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114822 HGNC: 19973 AceView: RHPN1 Ensembl:ENSG00000158106 euGenes: HUgn114822
    ECgene: RHPN1 H-InvDB: RHPN1

    (According to HUGE)
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    HUGE: KIAA1929

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHPN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHPN1 gene:
    Search GeneIP for patents involving RHPN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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