RHOXF2 Gene
protein-coding GIFtS: 44
GCID: GC0XP119292
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Rhox homeobox family, member 2
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Aliases
for RHOXF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rhox Homeobox Family, Member 21 2 | | Testis Homeobox Gene 12 3 | | PEPP21 2 3 5 | | Cancer/Testis Antigen 1072 | | THG11 2 3 | | Homeobox Protein From AL5905262 | | CT1071 2 | | PEPP Subfamily Gene 22 | | PEPP-21 2 | | Rhox Homeobox Family Member 22 | | Paired-Like Homeobox Protein PEPP-22 3 | | |
Export aliases for RHOXF2 gene to outside databasesPrevious GC identifers: GC0XP119177 GC0XP108744 |
Summaries
for RHOXF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RHOXF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RHOXF2 gene promoter:
MZF-1 Pax-5 POU6F1 (c2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for RHOXF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOXF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24RHOXF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP119292: view genomic region
(about GC identifiers)
Start:
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119,292,467 bp from pter |
End:
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119,297,945 bp from pter |
Size:
|
5,479 bases |
Orientation:
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plus strand |
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Proteins
for RHOXF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHXF2_HUMAN, Q9BQY4 (See
protein sequence)Recommended Name: Rhox homeobox family member 2 Size: 288 amino acids; 31692 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q9BR00Explore the universe of human proteins at neXtProt for RHOXF2: NX_Q9BQY4
RHOXF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115887.1
ENSEMBL proteins: ENSP00000360441
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
RHOXF2 for ontologies About GeneDecksing
RHOXF2 Antibody Products:
Assay Products for RHOXF2: |
Protein
Domains /
Families
for RHOXF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RHOXF2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BQY4ProtoNet protein and cluster: Q9BQY4 UniProtKB/Swiss-Prot: RHXF2_HUMAN, Q9BQY4Similarity: Belongs to the paired-like homeobox family. PEPP subfamilySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for RHOXF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOXF2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOXF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RHOXF2 (NM_032498) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHOXF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOXF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOXF2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | 19060904 | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
RHOXF2 for ontologies About GeneDecksing
|
Pathways & Interactions
for RHOXF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHOXF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/93 Interacting proteins for RHOXF2 (Q9BQY41, 2, 3 ENSP000003604414) via UniProtKB, MINT, STRING, and/or I2D (see all 93)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| EFEMP2 | O959671, 2, 3, ENSP000003099534 | EBI-372094,EBI-743414 MINT-68138 I2D:
score=5 STRING: ENSP00000309953 | | ATN1 | P542592, 3, ENSP000003490764 | MINT-2877289 MINT-2855044 I2D:
score=2 STRING: ENSP00000349076 | | CCNK | O759092, 3, ENSP000003745294 | MINT-67823 I2D:
score=5 STRING: ENSP00000374529 | | CLASRP | Q8N2M82, 3, ENSP000002214554 | MINT-68015 I2D:
score=5 STRING: ENSP00000221455 | | RADIL | Q96JH82, 3, ENSP000003824924 | MINT-66865 I2D:
score=5 STRING: ENSP00000382492 |
About this table
|
Drugs & Compounds
for RHOXF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RHOXF2
Search CenterWatch for drugs/clinical trials and news about RHOXF2 / RHXF2
|
Transcripts
for RHOXF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RHOXF2 gene: NM_032498.1 Unigene Cluster for RHOXF2: Rhox homeobox family, member 2 Hs.567620 [show with all ESTs]Unigene Representative Sequence: AL5905261 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000371388(uc004esl.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOXF2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOXF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RHOXF2 (NM_032498) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHOXF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOXF2 |
Additional cDNA sequence: AF317219.1 AK058125.1 AL590524.1 AL590526.1 BC021719.2 3 DOTS entries: DT.100728321 DT.306192 DT.121298822 24 AceView cDNA sequences: BE046930 AL590524 BG187299 CA424288 AI209091 AA933590 BQ772544 BG187298 AI657125 BI460790 BG212049 BP369633 CB161165 BG719503 BX093928 AI954612 BG184794 BG198630 BG217511 CB160268 BI561356 BI831246 R69179 BG215382
GeneLoc Exon Structure
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Expression
for RHOXF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RHOXF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTCAGTAA
About this image
See RHOXF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHOXF2
SOURCE GeneReport for Unigene cluster: Hs.567620
UniProtKB/Swiss-Prot: RHXF2_HUMAN, Q9BQY4Tissue specificity: Testis. Not detected in epididymis nor placenta
SABiosciences Custom PCR Arrays for RHOXF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOXF2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RHOXF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOXF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOXF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOXF2 |
Orthologs
for RHOXF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for RHOXF2 (if available)
TreeFam Gene Tree for RHOXF2 (if available) |
Paralogs
for RHOXF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RHOXF2 gene
- RHOXF2B1 2 RHOXF12 ESX12
2 SIMAP similar genes for RHOXF2 using alignment to 1 protein entry: RHXF2_HUMAN:RHOXF2B RAX2
RHOXF2 for paralogs About GeneDecksing
|
Genomic Variants
for RHOXF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RHOXF2 (119292467 - 119297945 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RHOXF2
1 CNV: 4167
2 Indels: 33488 33489
1 Inversion: 37346 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RHOXF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RHOXF2 for disorders About GeneDecksing
OMIM gene information: 300447
OMIM disorders: --
1  disease for RHOXF2: About MalaCardsataxia
Export disorders for RHOXF2 gene to outside databases
|
Publications
for RHOXF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RHOXF2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with RHOXF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. (PubMed id 12490318)1, 2, 3 Wayne C.M....Wilkinson M.F. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of RHOXF2 (PEPP2) as a cancer-promotin g gene by expression cloning. (PubMed id 21874235)1 Shibata-Minoshima F....Kitamura T. (2012)
- Kinetic analysis of 3'-5' nucleotide addition catalyze d by eukaryotic tRNA(His) guanylyltransferase. (PubMed id 22136300)1 Smith B.A. and Jackman J.E. (2012)
- Rapid evolution and copy number variation of primate R HOXF2, an X-linked homeobox gene involved in male reproduction and possibly brai n function. (PubMed id 21988730)1 Niu A.L....Su B. (2011)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (2009)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
|
External Searches for RHOXF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RHOXF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RHOXF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RHOXF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RHOXF2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RHOXF2 gene:
Search GeneIP for patents involving RHOXF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RHOXF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RHOXF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOXF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOXF2 | | | OriGene Protein Over-expression Lysate for RHOXF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RHOXF2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOXF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOXF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RHOXF2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RHOXF2 | | OriGene Custom Protein Services for RHOXF2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHOXF2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHOXF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOXF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOXF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOXF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOXF2 |
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| | | | Search Tocris compounds for RHOXF2 |
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 | | | RHOXF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOXF2 |
|  |  |  | | | | Search ThermoFisher Antibodies for RHOXF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOXF2 |
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