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Aliases for RHOXF2 Gene

Aliases for RHOXF2 Gene

  • Rhox Homeobox Family Member 2 2 3 5
  • Paired-Like Homeobox Protein PEPP-2 3 4
  • Cancer/Testis Antigen 107 2 3
  • Testis Homeobox Gene 1 3 4
  • PEPP2 3 4
  • THG1 3 4
  • Rhox Homeobox Family, Member 2 2
  • Homeobox Protein From AL590526 3
  • PEPP Subfamily Gene 2 3
  • PEPP-2 3
  • CT107 3

External Ids for RHOXF2 Gene

Previous GeneCards Identifiers for RHOXF2 Gene

  • GC0XP119177
  • GC0XP119292
  • GC0XP108744

Summaries for RHOXF2 Gene

Entrez Gene Summary for RHOXF2 Gene

  • This gene, which encodes a transcriptional repressor, is one of two paralogous X-linked homeobox-containing genes and is highly expressed in a variety of cancers. In addition, the encoded protein associates with the cell membrane and with microtubules, and is concentrated at the leading edge of migratory cells. [provided by RefSeq, Dec 2015]

GeneCards Summary for RHOXF2 Gene

RHOXF2 (Rhox Homeobox Family Member 2) is a Protein Coding gene. Diseases associated with RHOXF2 include Thoracic Benign Neoplasm and Breast Benign Neoplasm. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is RHOXF2B.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOXF2 Gene

Genomics for RHOXF2 Gene

Regulatory Elements for RHOXF2 Gene

Enhancers for RHOXF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG120144 1 Ensembl ENCODE 0.4 -14.1 -14139 0.4 EBF1 RELA EGR1 EED ETV6 RELB ZNF652 MTA2 RNF2 NR2F1 RHOXF2 LINC01402
GH0XG120140 0.5 ENCODE 0.4 -18.1 -18111 0.2 MAX POU5F1 EZH2 RHOXF1 RHOXF2 LINC01402
GH0XG120150 0.4 Ensembl 0.4 -7.8 -7839 0.2 REST RHOXF2 LINC01402
GH0XG120125 0.5 ENCODE 0.3 -32.9 -32907 0.7 CREB3 IRF2 IRF1 RHOXF1-AS1 LINC01402 RHOXF2
GH0XG120142 0.3 FANTOM5 0.4 -16.1 -16061 0.1 TMEM255A RHOXF2 LINC01402
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOXF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOXF2 Gene

120,158,539 bp from pter
120,165,630 bp from pter
7,092 bases
Plus strand

Genomic View for RHOXF2 Gene

Genes around RHOXF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOXF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOXF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOXF2 Gene

Proteins for RHOXF2 Gene

  • Protein details for RHOXF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rhox homeobox family member 2
    Protein Accession:
    Secondary Accessions:
    • Q9BR00

    Protein attributes for RHOXF2 Gene

    288 amino acids
    Molecular mass:
    31692 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RHOXF2 Gene

Post-translational modifications for RHOXF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOXF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOXF2 Gene

Domains & Families for RHOXF2 Gene

Gene Families for RHOXF2 Gene

Protein Domains for RHOXF2 Gene

Suggested Antigen Peptide Sequences for RHOXF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the paired-like homeobox family. PEPP subfamily.
  • Belongs to the paired-like homeobox family. PEPP subfamily.
genes like me logo Genes that share domains with RHOXF2: view

Function for RHOXF2 Gene

Gene Ontology (GO) - Molecular Function for RHOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with RHOXF2: view

Phenotypes for RHOXF2 Gene

GenomeRNAi human phenotypes for RHOXF2:
genes like me logo Genes that share phenotypes with RHOXF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RHOXF2 Gene

Localization for RHOXF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOXF2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOXF2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RHOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RHOXF2: view

Pathways & Interactions for RHOXF2 Gene

SuperPathways for RHOXF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RHOXF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010628 positive regulation of gene expression IMP 28171660
genes like me logo Genes that share ontologies with RHOXF2: view

No data available for Pathways by source and SIGNOR curated interactions for RHOXF2 Gene

Drugs & Compounds for RHOXF2 Gene

No Compound Related Data Available

Transcripts for RHOXF2 Gene

mRNA/cDNA for RHOXF2 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOXF2 Gene

Rhox homeobox family, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOXF2 Gene

No ASD Table

Relevant External Links for RHOXF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOXF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOXF2 Gene

mRNA differential expression in normal tissues according to GTEx for RHOXF2 Gene

This gene is overexpressed in Testis (x46.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RHOXF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOXF2 Gene:


SOURCE GeneReport for Unigene cluster for RHOXF2 Gene:


mRNA Expression by UniProt/SwissProt for RHOXF2 Gene:

Tissue specificity: Testis. Not detected in epididymis nor placenta.
genes like me logo Genes that share expression patterns with RHOXF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOXF2 Gene

Orthologs for RHOXF2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RHOXF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 93 (a)
-- 35
  • 82 (a)
(Canis familiaris)
Mammalia -- 35
  • 22 (a)
-- 35
  • 22 (a)
Species where no ortholog for RHOXF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RHOXF2 Gene

Gene Tree for RHOXF2 (if available)
Gene Tree for RHOXF2 (if available)

Paralogs for RHOXF2 Gene

Paralogs for RHOXF2 Gene

(1) SIMAP similar genes for RHOXF2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RHOXF2: view

Variants for RHOXF2 Gene

Sequence variations from dbSNP and Humsavar for RHOXF2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs140341265 -- 120,159,179(+) GCGGC(A/G)GCGCC reference, missense
rs140903249 -- 120,159,217(+) GACCT(C/T)GAGGG reference, synonymous-codon
rs142899626 -- 120,159,387(+) GGAGC(A/G)CATTT reference, missense
rs142963365 -- 120,159,346(+) CCCAA(C/T)GTCCA reference, synonymous-codon
rs143283202 -- 120,159,140(+) GCGGA(A/G)AAGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RHOXF2 Gene

Variant ID Type Subtype PubMed ID
esv2758888 CNV gain 17122850
nsv526653 CNV gain 19592680
nsv7457 OTHER inversion 18451855
nsv9970 CNV gain 18304495
nsv9971 CNV gain 18304495

Variation tolerance for RHOXF2 Gene

Gene Damage Index Score: 1.13; 22.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOXF2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOXF2 Gene

Disorders for RHOXF2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RHOXF2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
thoracic benign neoplasm
  • benign neoplasm of thorax
breast benign neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RHOXF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RHOXF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RHOXF2 Gene

Publications for RHOXF2 Gene

  1. Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. (PMID: 12490318) Wayne C.M. … Wilkinson M.F. (Gene 2002) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The human RHOX gene cluster: target genes and functional analysis of gene variants in infertile men. (PMID: 28171660) Borgmann J. … Gromoll J. (Hum. Mol. Genet. 2016) 3 64
  5. Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues. (PMID: 26464818) Kazemi-Oula G. … Modarressi M.H. (Cell J 2015) 3 64

Products for RHOXF2 Gene

Sources for RHOXF2 Gene

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