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Aliases for RHOXF1 Gene

Aliases for RHOXF1 Gene

  • Rhox Homeobox Family, Member 1 2 3
  • PEPP1 3 4 6
  • OTEX 3 4 6
  • Ovary-, Testis- And Epididymis-Expressed Gene Protein 3 4
  • Paired-Like Homeobox Protein PEPP-1 3 4
  • Rhox Homeobox Family Member 1 3
  • PEPP Subfamily Gene 1 3

External Ids for RHOXF1 Gene

Previous GeneCards Identifiers for RHOXF1 Gene

  • GC0XM119128
  • GC0XM119243
  • GC0XM108694

Summaries for RHOXF1 Gene

Entrez Gene Summary for RHOXF1 Gene

  • This gene is a member of the PEPP subfamily of paired-like homoebox genes. The gene may be regulated by androgens and epigenetic mechanisms. The encoded nuclear protein is likely a transcription factor that may play a role in human reproduction. [provided by RefSeq, Dec 2012]

GeneCards Summary for RHOXF1 Gene

RHOXF1 (Rhox Homeobox Family, Member 1) is a Protein Coding gene. Diseases associated with RHOXF1 include endometrial adenocarcinoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is ESX1.

UniProtKB/Swiss-Prot for RHOXF1 Gene

  • May be a transcription factor involved in reproductive processes

Gene Wiki entry for RHOXF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOXF1 Gene

Genomics for RHOXF1 Gene

Regulatory Elements for RHOXF1 Gene

Genomic Location for RHOXF1 Gene

Start:
120,109,053 bp from pter
End:
120,115,937 bp from pter
Size:
6,885 bases
Orientation:
Minus strand

Genomic View for RHOXF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOXF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOXF1 Gene

Proteins for RHOXF1 Gene

  • Protein details for RHOXF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHV9-RHXF1_HUMAN
    Recommended name:
    Rhox homeobox family member 1
    Protein Accession:
    Q8NHV9
    Secondary Accessions:
    • O95030
    • Q3SYE0

    Protein attributes for RHOXF1 Gene

    Size:
    184 amino acids
    Molecular mass:
    20542 Da
    Quaternary structure:
    • Does not interact with itself
    SequenceCaution:
    • Sequence=AAC78617.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RHOXF1 Gene

Proteomics data for RHOXF1 Gene at MOPED

Post-translational modifications for RHOXF1 Gene

No Post-translational modifications

Other Protein References for RHOXF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOXF1 Gene

Domains for RHOXF1 Gene

Gene Families for RHOXF1 Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Suggested Antigen Peptide Sequences for RHOXF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHV9

UniProtKB/Swiss-Prot:

RHXF1_HUMAN :
  • Q8NHV9
Domain:
  • Mutagenesis of amino acids 147 to 164 and 155 to 164 lead to a major cytoplasmic localization, with only minor localization in the nucleus
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the paired-like homeobox family. PEPP subfamily.
genes like me logo Genes that share domains with RHOXF1: view

Function for RHOXF1 Gene

Molecular function for RHOXF1 Gene

UniProtKB/Swiss-Prot Function: May be a transcription factor involved in reproductive processes
UniProtKB/Swiss-Prot Induction: By androgen

Gene Ontology (GO) - Molecular Function for RHOXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 11980563
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 12490318
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with RHOXF1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RHOXF1 Gene

Localization for RHOXF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOXF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOXF1 Gene COMPARTMENTS Subcellular localization image for RHOXF1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RHOXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11980563
genes like me logo Genes that share ontologies with RHOXF1: view

Pathways for RHOXF1 Gene

SuperPathways for RHOXF1 Gene

No Data Available

Interacting Proteins for RHOXF1 Gene

Gene Ontology (GO) - Biological Process for RHOXF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 11980563
GO:0007275 multicellular organismal development NAS 11980563
GO:0007276 gamete generation NAS 11980563
GO:0019953 sexual reproduction IEP 11980563
genes like me logo Genes that share ontologies with RHOXF1: view

No data available for Pathways by source for RHOXF1 Gene

Transcripts for RHOXF1 Gene

mRNA/cDNA for RHOXF1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOXF1 Gene

Rhox homeobox family, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RHOXF1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RHOXF1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOXF1 Gene

No ASD Table

Relevant External Links for RHOXF1 Gene

GeneLoc Exon Structure for
RHOXF1
ECgene alternative splicing isoforms for
RHOXF1

Expression for RHOXF1 Gene

mRNA expression in normal human tissues for RHOXF1 Gene

mRNA differential expression in normal tissues according to GTEx for RHOXF1 Gene

This gene is overexpressed in Testis (9.8), Brain - Cerebellar Hemisphere (5.6), and Brain - Cerebellum (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RHOXF1 Gene

SOURCE GeneReport for Unigene cluster for RHOXF1 Gene Hs.644617

mRNA Expression by UniProt/SwissProt for RHOXF1 Gene

Q8NHV9-RHXF1_HUMAN
Tissue specificity: Ovary, testis and epididymis. Also detected in the prostate and the mammary gland. Expressed in many tumor cell lines derived from acute lymphocytic leukemia, prostate, endometrial adenocarcinoma, melanoma, bladder carcinoma, colon carcinoma, erythroleukemia and breast carcinoma. Not expressed in placenta.
genes like me logo Genes that share expressions with RHOXF1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RHOXF1 Gene

Orthologs for RHOXF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RHOXF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOXF1 35
  • 98 (n)
  • 98 (a)
dog
(Canis familiaris)
Mammalia LOC481034 35
  • 63.33 (n)
  • 49.23 (a)
RHOXF1 36
  • 36 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhox13 36
  • 19 (a)
OneToOne
Species with no ortholog for RHOXF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RHOXF1 Gene

ENSEMBL:
Gene Tree for RHOXF1 (if available)
TreeFam:
Gene Tree for RHOXF1 (if available)

Paralogs for RHOXF1 Gene

Paralogs for RHOXF1 Gene

Selected SIMAP similar genes for RHOXF1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RHOXF1: view

Variants for RHOXF1 Gene

Sequence variations from dbSNP and Humsavar for RHOXF1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs2301977 - 120,109,232(+) CAGCA(C/T)GTAGT missense, reference
rs5909684 -- 120,112,484(+) atgta(A/T)tatat intron-variant
rs5910765 -- 120,112,483(+) tatgt(A/T)ttata intron-variant
rs5910766 -- 120,112,509(+) tgtat(A/T)atata intron-variant
rs5910767 -- 120,114,316(+) actca(C/G)gaggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOXF1 Gene

Variant ID Type Subtype PubMed ID
dgv2469e1 CNV Complex 17122850
nsv7457 OTHER Inversion 18451855
nsv526653 CNV Gain 19592680
esv1505897 CNV Insertion 17803354

Relevant External Links for RHOXF1 Gene

HapMap Linkage Disequilibrium report
RHOXF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOXF1 Gene

Disorders for RHOXF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RHOXF1 Gene including...

Search for RHOXF1 Gene in MalaCards »
genes like me logo Genes that share disorders with RHOXF1: view

No data available for UniProtKB/Swiss-Prot for RHOXF1 Gene

Publications for RHOXF1 Gene

  1. OTEX, an androgen-regulated human member of the paired-like class of homeobox genes. (PMID: 11980563) Geserick C. … Haendler B. (Biochem. J. 2002) 2 3 4 23
  2. Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. (PMID: 12490318) Wayne C.M. … Wilkinson M.F. (Gene 2002) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for RHOXF1 Gene

Sources for RHOXF1 Gene

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