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Aliases for RHOV Gene

Aliases for RHOV Gene

  • Ras Homolog Family Member V 2 3 5
  • Ras Homolog Gene Family, Member V 2 3
  • Wnt-1 Responsive Cdc42 Homolog 2 3 4
  • Rho GTPase-Like Protein ARHV 3 4
  • GTP-Binding Protein-Like 2 3 4
  • CDC42-Like GTPase 2 3 4
  • WRCH-2 3 4
  • WRCH2 3 4
  • ARHV 3 4
  • Rho-Related GTP-Binding Protein RhoV 3
  • Wnt-1 Regulated Cdc42 Homolog 2 3
  • WRCH1-Related GTPase 3
  • CHP 3

External Ids for RHOV Gene

Previous HGNC Symbols for RHOV Gene

  • ARHV

Previous GeneCards Identifiers for RHOV Gene

  • GC15M038881
  • GC15M038952
  • GC15M041164
  • GC15M018012

Summaries for RHOV Gene

GeneCards Summary for RHOV Gene

RHOV (Ras Homolog Family Member V) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include GTP binding. An important paralog of this gene is RHOU.

UniProtKB/Swiss-Prot for RHOV Gene

  • Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOV Gene

Genomics for RHOV Gene

Regulatory Elements for RHOV Gene

Enhancers for RHOV Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G040905 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11 -32.6 -32632 3.7 HDGF ATF1 AGO1 ARID4B SIN3A ZNF2 YY1 ZNF121 GLIS2 ZNF143 CHAC1 RHOV EXD1 CHP1 DLL4 ENSG00000251161
GH15G040791 1.5 Ensembl ENCODE dbSUPER 10.7 +79.9 79852 5.2 FOXA2 ARID4B FEZF1 BRCA1 YY1 FOS PAF1 MIER2 PPARG KAT8 ZFYVE19 RMDN3 C15orf57 C15orf62 SPINT1 GCHFR RAD51 RAD51-AS1 RHOV RPUSD2
GH15G040785 1.3 Ensembl ENCODE dbSUPER 10.7 +86.8 86776 4.4 NFIB RAD21 SCRT2 FOS PAF1 CEBPB ZNF398 REST ZNF217 MAFF ZFYVE19 C15orf57 RMDN3 GCHFR SPINT1 RAD51 RAD51-AS1 RHOV VPS18 ENSG00000251161
GH15G040742 1.2 Ensembl ENCODE 10.8 +128.4 128366 7.4 PKNOX1 FOXA2 ATF1 ARID4B SIN3A TCF12 ZNF121 ZNF766 ELK1 FOS C15orf57 RAD51 C15orf62 ZFYVE19 DNAJC17 RAD51-AS1 SPINT1 RHOV VPS18 ENSG00000251161
GH15G040875 1.4 Ensembl ENCODE dbSUPER 6.8 -3.5 -3544 4.8 HDGF TBP FOXA2 WRNIP1 RFX5 RELB FOS IKZF2 KLF13 CREM RHOV ENSG00000274798 GC15P040890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOV on UCSC Golden Path with GeneCards custom track

Promoters for RHOV Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075571 189 601 PKNOX1 ATF1 SIN3A ZNF48 GLIS2 ZNF207 ZNF143 KLF13 REST SMARCB1

Genomic Location for RHOV Gene

40,872,214 bp from pter
40,874,289 bp from pter
2,076 bases
Minus strand

Genomic View for RHOV Gene

Genes around RHOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOV Gene

Proteins for RHOV Gene

  • Protein details for RHOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related GTP-binding protein RhoV
    Protein Accession:
    Secondary Accessions:
    • Q2KHQ5
    • Q8TDW6

    Protein attributes for RHOV Gene

    236 amino acids
    Molecular mass:
    26217 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PAK2.

neXtProt entry for RHOV Gene

Post-translational modifications for RHOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOV Gene

Domains & Families for RHOV Gene

Gene Families for RHOV Gene

Suggested Antigen Peptide Sequences for RHOV Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rho family.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOV: view

Function for RHOV Gene

Molecular function for RHOV Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

Gene Ontology (GO) - Molecular Function for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 16752908
GO:0005525 GTP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RHOV: view
genes like me logo Genes that share phenotypes with RHOV: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOV Gene

Localization for RHOV Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOV Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250 UniProtKB:Q9Z1Y0}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOV gene
Compartment Confidence
cytosol 5
plasma membrane 4
endosome 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with RHOV: view

Pathways & Interactions for RHOV Gene

genes like me logo Genes that share pathways with RHOV: view

Pathways by source for RHOV Gene

Gene Ontology (GO) - Biological Process for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOV: view

No data available for SIGNOR curated interactions for RHOV Gene

Drugs & Compounds for RHOV Gene

(1) Drugs for RHOV Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with RHOV: view

Transcripts for RHOV Gene

mRNA/cDNA for RHOV Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOV Gene

Ras homolog family member V:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOV Gene

No ASD Table

Relevant External Links for RHOV Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOV Gene

This gene is overexpressed in Esophagus - Mucosa (x14.4), Skin - Sun Exposed (Lower leg) (x9.2), Skin - Not Sun Exposed (Suprapubic) (x9.0), and Vagina (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of RHOV Gene:


SOURCE GeneReport for Unigene cluster for RHOV Gene:


mRNA Expression by UniProt/SwissProt for RHOV Gene:

Tissue specificity: Highly expressed in pancreas, placenta, and fetal brain.
genes like me logo Genes that share expression patterns with RHOV: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOV Gene

Orthologs for RHOV Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOV Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOV 34 35
  • 99.44 (n)
(Monodelphis domestica)
Mammalia RHOV 35
  • 94 (a)
(Canis familiaris)
Mammalia RHOV 34 35
  • 93.22 (n)
(Bos Taurus)
Mammalia RHOV 34 35
  • 92.23 (n)
(Rattus norvegicus)
Mammalia Rhov 34
  • 90.54 (n)
(Mus musculus)
Mammalia Rhov 34 16 35
  • 89.55 (n)
(Ornithorhynchus anatinus)
Mammalia RHOV 35
  • 80 (a)
(Gallus gallus)
Aves RHOV 34 35
  • 78.1 (n)
(Anolis carolinensis)
Reptilia RHOV 35
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhov 34
  • 72.3 (n)
Str.15841 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2434 34
(Danio rerio)
Actinopterygii rhov 34 35
  • 63.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34104 35
  • 17 (a)
(Caenorhabditis elegans)
Secernentea chw-1 35
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9013 35
  • 50 (a)
Species where no ortholog for RHOV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOV Gene

Gene Tree for RHOV (if available)
Gene Tree for RHOV (if available)

Paralogs for RHOV Gene

Paralogs for RHOV Gene

genes like me logo Genes that share paralogs with RHOV: view

Variants for RHOV Gene

Sequence variations from dbSNP and Humsavar for RHOV Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1001097613 -- 40,872,788(+) ACTGA(A/C)CCTGT utr-variant-3-prime
rs1001304523 -- 40,871,792(+) AACCT(C/G)AGCCC downstream-variant-500B
rs1001354719 -- 40,872,125(+) TGGTC(C/T)CCAAT downstream-variant-500B
rs1001697263 -- 40,874,868(+) ATGGG(C/T)GAGAA upstream-variant-2KB
rs1002326673 -- 40,873,277(+) ACGGG(A/G)CCCTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RHOV Gene

Variant ID Type Subtype PubMed ID
nsv1054764 CNV gain 25217958
nsv569228 CNV loss 21841781

Variation tolerance for RHOV Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOV Gene

Disorders for RHOV Gene

Relevant External Links for RHOV

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RHOV Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOV Gene

Publications for RHOV Gene

  1. The Rho GTPase family: a Racs to Wrchs story. (PMID: 11839775) Wherlock M. … Mellor H. (J. Cell Sci. 2002) 2 3 4 64
  2. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. (PMID: 11956592) Katoh M. (Int. J. Oncol. 2002) 3 4 22 64
  3. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64
  4. The RHOV gene is overexpressed in human non-small cell lung cancer. (PMID: 24388711) Shepelev M.V. … Korobko I.V. (Cancer Genet 2013) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for RHOV Gene

Sources for RHOV Gene

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