RHOV Gene
protein-coding GIFtS: 51
GCID: GC15M041164
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|
ras homolog family member V(Previous names: ras homolog gene family, member V )
(Previous symbol: ARHV)
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Aliases
for RHOV gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ras Homolog Family Member V1 2 | | Rho GTPase-Like Protein ARHV2 3 | | ARHV1 2 3 | | Wnt-1 Responsive Cdc42 Homolog 22 3 | | WRCH21 2 3 | | Chp1 | | Ras Homolog Gene Family, Member V1 2 | | CHP2 | | WRCH-22 3 | | Rho-Related GTP-Binding Protein RhoV2 | | CDC42-Like GTPase 22 3 | | Wnt-1 Regulated Cdc42 Homolog 22 | | GTP-Binding Protein-Like 22 3 | | WRCH1-Related GTPase2 |
Export aliases for RHOV gene to outside databasesPrevious GC identifers: GC15M038881 GC15M038952 GC15M018012 |
Summaries
for RHOV gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RHOV_HUMAN, Q96L33Function: Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (By similarity)
|
Genomic Views
for RHOV gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RHOV gene promoter:
SRF Pax-5 SRF (504 AA) Nkx3-1 v1 LUN-1 E47 RORalpha2 CREB Nkx6-1 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for RHOV
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOV |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q13.3 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q13.3RHOV Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M041164: view genomic region
(about GC identifiers)
Start:
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41,164,412 bp from pter |
End:
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41,166,487 bp from pter |
Size:
|
2,076 bases |
Orientation:
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minus strand |
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Proteins
for RHOV gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RHOV_HUMAN, Q96L33 (See
protein sequence)Recommended Name: Rho-related GTP-binding protein RhoV Size: 236 amino acids; 26217 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with PAK2 (By similarity)
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Endosome membrane; Lipid-anchor;Cytoplasmic side (By similarity). Note=Treatment with TNF activates endosomal but not plasma membrane RHOV (Bysimilarity)
Secondary accessions: Q2KHQ5 Q8TDW6Explore the universe of human proteins at neXtProt for RHOV: NX_Q96L33
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96L33
RHOV Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_598378.3
ENSEMBL proteins: ENSP00000220507 Reactome Protein details: Q96L33
Human Recombinant Protein Products for RHOV:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RHOV for ontologies About GeneDecksing
RHOV Antibody Products:
Assay Products for RHOV: |
Protein
Domains /
Families
for RHOV gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RHOV for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96L33ProtoNet protein and cluster: Q96L33 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RHOV_HUMAN, Q96L33Similarity: Belongs to the small GTPase superfamily. Rho family |
Function
for RHOV gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RHOV_HUMAN, Q96L33Function: Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RHOV for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for RHOV:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOV (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOV
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RHOV (NM_133639) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHOV | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOV |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOV |
|
Pathways & Interactions
for RHOV gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for RHOV
RHOV for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHOV
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/69 Interacting proteins for RHOV (Q96L332, 3 ENSP000002205074) via UniProtKB, MINT, STRING, and/or I2D (see all 69)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
-- | -- | | GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
TAS | -- |
RHOV for ontologies About GeneDecksing
|
Drugs & Compounds
for RHOV gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RHOV
1 HMDB Compound for RHOV About this table
Search CenterWatch for drugs/clinical trials and news about RHOV
|
Transcripts
for RHOV gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RHOV gene: NM_133639.3 Unigene Cluster for RHOV: Ras homolog family member V Hs.447901 [show with all ESTs]Unigene Representative Sequence: NM_1336391 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000220507(uc001znd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOV (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOV
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RHOV (NM_133639) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RHOV | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOV |
Additional cDNA sequence: AB079131.1 AY059636.1 BC019353.1 BC105020.1 BC105022.1 BC112945.1 3 DOTS entries: DT.428432 DT.95367590 DT.95330936 24/29 AceView cDNA sequences (see all 29): AY059636 CR615243 AI690344 NM_133639 CR618466 AB079131 BX357883 CR599960 BC019353 CB851513 BE076026 BE794346 BX357884 BX377326 AA367838 D78924 BG290065 AA339401 BX344621 BE547917 AW514309 BX365623 BI193105 BF747335
GeneLoc Exon Structure
|
Expression
for RHOV gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RHOV expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATGGTCCT
About this image
See RHOV Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHOV
SOURCE GeneReport for Unigene cluster: Hs.447901
UniProtKB/Swiss-Prot: RHOV_HUMAN, Q96L33Tissue specificity: Highly expressed in pancreas, placenta, and fetal brain
SABiosciences Expression via Pathway-Focused PCR Array including RHOV:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOV
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOV | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOV | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOV | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOV |
Orthologs
for RHOV gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RHOV gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for RHOV (if available)
TreeFam Gene Tree for RHOV (if available) |
Paralogs
for RHOV gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RHOV gene
- RHOBTB22 RHOH2 RHOQ2 RAC12 RHOBTB12 RAC22 CDC422 RHOJ2
- RHOG2 RHOU2 RAC32
18/39 SIMAP similar genes for RHOV using alignment to 2 protein entries: RHOV_HUMAN (see all proteins)
(see all similar genes):CDC42 RAC2 RAC3 ARHG RHOG RAC1
RHOA RHOB RHOD RHOC RHOQ RHOJ
RHOU RHOH ARHH ARHA RAB37 ARHE
RHOV for paralogs About GeneDecksing
|
Genomic Variants
for RHOV gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RHOV (41164412 - 41166487 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RHOV: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHOV |
|
Disorders
/ Diseases
for RHOV gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RHOV for disorders About GeneDecksing
1  disease for RHOV: About MalaCardspharyngitis
Export disorders for RHOV gene to outside databases
|
Publications
for RHOV gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RHOV gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with RHOV) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The Rho GTPase family: a Racs to Wrchs story. (PubMed id 11839775)1, 2, 3 Wherlock M. and Mellor H. (2002)
- Molecular cloning and characterization of WRCH2 on human chromosome 15q15. (PubMed id 11956592)1, 2, 9 Katoh M. (2002)
- Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV. (PubMed id 22339630)1 Shepelev M.V. and Korobko I.V. (2012)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Evolution of the Rho family of ras-like GTPases in eukaryotes. (PubMed id 17035353)1 Boureux A....Fort P. (2007)
- Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. (PubMed id 17355222)1 Weisz Hubsman M....Aronheim A. (2007)
- Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. (PubMed id 15664990)1 Chenette E.J....Der C.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton. (PubMed id 9778532)1 Aronheim A....Abo A. (1998)
|
External Searches for RHOV gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RHOV gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RHOV gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RHOV gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RHOV | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RHOV gene:
Search GeneIP for patents involving RHOV
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RHOV gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RHOV | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOV | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RHOV | | | OriGene Protein Over-expression Lysate for RHOV | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RHOV | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOV | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOV | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RHOV | | OriGene Custom Protein Services for RHOV | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHOV | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RHOV | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOV | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOV | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOV | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOV |
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 |  |  |  | |
| | | | Search Tocris compounds for RHOV |
| |  |  |  |  | | | | | | Recombinant Protein for RHOV |
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 | | | RHOV Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOV |
|  |  |  |  | | | | Search ThermoFisher Antibodies for RHOV |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOV |
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