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Aliases for RHOV Gene

Aliases for RHOV Gene

  • Ras Homolog Family Member V 2 3
  • Ras Homolog Gene Family, Member V 2 3
  • Wnt-1 Responsive Cdc42 Homolog 2 3 4
  • Rho GTPase-Like Protein ARHV 3 4
  • GTP-Binding Protein-Like 2 3 4
  • CDC42-Like GTPase 2 3 4
  • WRCH-2 3 4
  • WRCH2 3 4
  • ARHV 3 4
  • Rho-Related GTP-Binding Protein RhoV 3
  • Wnt-1 Regulated Cdc42 Homolog 2 3
  • WRCH1-Related GTPase 3
  • CHP 3

External Ids for RHOV Gene

Previous HGNC Symbols for RHOV Gene

  • ARHV

Previous GeneCards Identifiers for RHOV Gene

  • GC15M038881
  • GC15M038952
  • GC15M041164
  • GC15M018012

Summaries for RHOV Gene

GeneCards Summary for RHOV Gene

RHOV (Ras Homolog Family Member V) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOV Gene

  • Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOV Gene

Genomics for RHOV Gene

Regulatory Elements for RHOV Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RHOV Gene

40,872,214 bp from pter
40,874,289 bp from pter
2,076 bases
Minus strand

Genomic View for RHOV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOV Gene

Proteins for RHOV Gene

  • Protein details for RHOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related GTP-binding protein RhoV
    Protein Accession:
    Secondary Accessions:
    • Q2KHQ5
    • Q8TDW6

    Protein attributes for RHOV Gene

    236 amino acids
    Molecular mass:
    26217 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PAK2.

neXtProt entry for RHOV Gene

Proteomics data for RHOV Gene at MOPED

Post-translational modifications for RHOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOV Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOV Gene

Domains for RHOV Gene

Suggested Antigen Peptide Sequences for RHOV Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96L33
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOV: view

No data available for Gene Families for RHOV Gene

Function for RHOV Gene

Molecular function for RHOV Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

Gene Ontology (GO) - Molecular Function for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16752908
GO:0005525 GTP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RHOV: view

Phenotypes for RHOV Gene

GenomeRNAi human phenotypes for RHOV:
genes like me logo Genes that share phenotypes with RHOV: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RHOV Gene

Localization for RHOV Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOV Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250 UniProtKB:Q9Z1Y0}.

Subcellular locations from

Jensen Localization Image for RHOV Gene COMPARTMENTS Subcellular localization image for RHOV gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005768 endosome --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with RHOV: view

Pathways for RHOV Gene

genes like me logo Genes that share pathways with RHOV: view

Pathways by source for RHOV Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0015031 protein transport --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOV: view

Compounds for RHOV Gene

(1) HMDB Compounds for RHOV Gene

Compound Synonyms Cas Number PubMed IDs
  • Magnesium
genes like me logo Genes that share compounds with RHOV: view

Transcripts for RHOV Gene

mRNA/cDNA for RHOV Gene

(6) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOV Gene

Ras homolog family member V:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RHOV

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOV Gene

No ASD Table

Relevant External Links for RHOV Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOV Gene

mRNA expression in normal human tissues for RHOV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOV Gene

This gene is overexpressed in Esophagus - Mucosa (14.4), Skin - Sun Exposed (Lower leg) (9.2), Skin - Not Sun Exposed (Suprapubic) (9.0), and Vagina (5.6).

SOURCE GeneReport for Unigene cluster for RHOV Gene Hs.447901

mRNA Expression by UniProt/SwissProt for RHOV Gene

Tissue specificity: Highly expressed in pancreas, placenta, and fetal brain.
genes like me logo Genes that share expressions with RHOV: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for RHOV Gene

Orthologs for RHOV Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOV Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RHOV 35
  • 92.23 (n)
  • 97.03 (a)
  • 96 (a)
(Canis familiaris)
Mammalia RHOV 35
  • 93.22 (n)
  • 98.31 (a)
  • 98 (a)
(Mus musculus)
Mammalia Rhov 35
  • 89.55 (n)
  • 99.15 (a)
Rhov 16
Rhov 36
  • 99 (a)
(Pan troglodytes)
Mammalia RHOV 35
  • 99.44 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rhov 35
  • 90.54 (n)
  • 98.31 (a)
(Monodelphis domestica)
Mammalia RHOV 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia RHOV 36
  • 80 (a)
(Gallus gallus)
Aves RHOV 35
  • 78.1 (n)
  • 84.06 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia RHOV 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rhov 35
  • 72.3 (n)
  • 77.78 (a)
Str.15841 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2434 35
(Danio rerio)
Actinopterygii rhov 35
  • 63.61 (n)
  • 65.22 (a)
rhov 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34104 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea chw-1 36
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9013 36
  • 50 (a)
Species with no ortholog for RHOV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOV Gene

Gene Tree for RHOV (if available)
Gene Tree for RHOV (if available)

Paralogs for RHOV Gene

Paralogs for RHOV Gene

genes like me logo Genes that share paralogs with RHOV: view

Variants for RHOV Gene

Sequence variations from dbSNP and Humsavar for RHOV Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1814692 -- 40,873,541(+) CCCCG(A/C)CACAT intron-variant
rs2279578 -- 40,872,146(+) CCAGG(C/T)AGTTA downstream-variant-500B
rs3803351 -- 40,873,564(-) GCCCC(A/G)GGTGA intron-variant
rs4923887 -- 40,874,330(+) ACCCA(C/T)CGGCG upstream-variant-2KB
rs34122473 -- 40,874,892(+) AGCCG(-/A)AAATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RHOV Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
nsv904102 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
nsv904104 CNV Loss 21882294

Relevant External Links for RHOV Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOV Gene

Disorders for RHOV Gene

No disorders were found for RHOV Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RHOV Gene

Publications for RHOV Gene

  1. The Rho GTPase family: a Racs to Wrchs story. (PMID: 11839775) Wherlock M. … Mellor H. (J. Cell Sci. 2002) 2 3 4
  2. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. (PMID: 11956592) Katoh M. (Int. J. Oncol. 2002) 3 4 23
  3. Biochemical analyses of the Wrch atypical Rho family GTPases. (PMID: 16472646) Shutes A. … Der C.J. (Methods Enzymol. 2006) 23
  4. Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton. (PMID: 9778532) Aronheim A. … Abo A. (Curr. Biol. 1998) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RHOV Gene

Sources for RHOV Gene

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