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RHOV Gene

protein-coding   GIFtS: 51
GCID: GC15M041164

Ras Homolog Family Member V

(Previous names: ras homolog gene family, member V)
(Previous symbol: ARHV)
  Search for RHOV
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member V1 2     Rho GTPase-Like Protein ARHV2 3
ARHV1 2 3     Wnt-1 Responsive Cdc42 Homolog 22 3
Ras Homolog Gene Family, Member V1 2     CHP2
WRCH-22 3     Rho-Related GTP-Binding Protein RhoV2
WRCH22 3     Wnt-1 Regulated Cdc42 Homolog 22
CDC42-Like GTPase 22 3     WRCH1-Related GTPase2
GTP-Binding Protein-Like 22 3     

External Ids:    HGNC: 183131   Entrez Gene: 1711772   Ensembl: ENSG000001041407   UniProtKB: Q96L333   

Export aliases for RHOV gene to outside databases

Previous GC identifers: GC15M038881 GC15M038952 GC15M018012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHOV Gene:
RHOV (ras homolog family member V) is a protein-coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RHOV_HUMAN, Q96L33
Function: Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOV gene promoter:
         SRF   Pax-5   SRF (504 AA)   Nkx3-1 v1   LUN-1   E47   RORalpha2   CREB   Nkx6-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOV promoter sequence
   Search Chromatin IP Primers for RHOV

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.3   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q13.3

RHOV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOV gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M041164:  view genomic region     (about GC identifiers)

Start:
41,164,412 bp from pter      End:
41,166,487 bp from pter
Size:
2,076 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHOV_HUMAN, Q96L33 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoV  
Size: 236 amino acids; 26217 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with PAK2 (By similarity)
Secondary accessions: Q2KHQ5 Q8TDW6

Explore the universe of human proteins at neXtProt for RHOV: NX_Q96L33

Explore proteomics data for RHOV at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RHOV Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_598378.3  
    ENSEMBL proteins: 
     ENSP00000220507  
    Reactome Protein details: Q96L33

    RHOV Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for RHOV
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RHOV
    GenScript Custom Purified and Recombinant Proteins Services for RHOV
    Novus Biologicals RHOV Protein
    Novus Biologicals RHOV Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RHOV
    Cloud-Clone Corp. Proteins for RHOV

     
    Search eBioscience for Proteins for RHOV 

    RHOV Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for RHOV
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    LSBio Antibodies in human, mouse, rat for RHOV

    RHOV Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOV
    Cloud-Clone Corp. CLIAs for RHOV
    Search eBioscience for ELISAs for RHOV 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q96L33

    ProtoNet protein and cluster: Q96L33

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOV_HUMAN, Q96L33
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RHOV           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOV_HUMAN, Q96L33
    Function: Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16752908
    GO:0005525GTP binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with RHOV           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RHOV:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHOV
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHOV

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOV
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOV

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOV:
    hsa-mir-331-3p (MIRT043355), hsa-mir-148b-3p (MIRT019317), hsa-mir-124-3p (MIRT002659), hsa-mir-9-5p (MIRT021431), hsa-mir-193b-3p (MIRT041402), hsa-mir-125b-5p (MIRT045896)

    Block miRNA regulation of human, mouse, rat RHOV using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOV (see all 16):
    hsa-miR-3934 hsa-miR-3135 hsa-miR-575 hsa-miR-449a hsa-miR-520g hsa-miR-515-3p hsa-miR-34c-5p hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidRHOV 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RHOV
    Predesigned siRNA for gene silencing in human, mouse, rat RHOV

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOV

    Clone
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    OriGene clones in human, mouse for RHOV (see all 5)
    OriGene ORF clones in mouse, rat for RHOV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOV (NM_133639)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOV

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RHOV
    Browse ESI BIO Cell Lines and PureStem Progenitors for RHOV 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOV


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOV_HUMAN, Q96L33: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Endosome membrane;
    Lipid-anchor; Cytoplasmic side (By similarity). Note=Treatment with TNF activates endosomal but not plasma
    membrane RHOV (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytosol4
    nucleus2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with RHOV           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOV About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with RHOV           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RHOV
        Rho GTPase cycle


        Pathway & Disease-focused RT2 Profiler PCR Array including RHOV: 
              Notch Signaling Targets in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RHOV

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOV (Q96L331, 2, 3 ENSP000002205074) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK2O436391, 2, 3, ENSP000002331544EBI-8538631,EBI-713635 MINT-7136689 MINT-7136744 MINT-7136756 MINT-7136704 I2D: score=1 STRING: ENSP00000233154
    SLC9A1P196343, ENSP000002639804I2D: score=1 STRING: ENSP00000263980
    STK17BO947683, ENSP000002639554I2D: score=1 STRING: ENSP00000263955
    A2MENSP000003239294STRING: ENSP00000323929
    ARHGDIAENSP000002693214STRING: ENSP00000269321
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport ----
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with RHOV           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOV

    1 HMDB Compound for RHOV    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHOV gene: 
    NM_133639.3  

    Unigene Cluster for RHOV:

    Ras homolog family member V
    Hs.447901  [show with all ESTs]
    Unigene Representative Sequence: NM_133639
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000220507(uc001znd.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RHOV using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOV (see all 16):
    hsa-miR-3934 hsa-miR-3135 hsa-miR-575 hsa-miR-449a hsa-miR-520g hsa-miR-515-3p hsa-miR-34c-5p hsa-miR-449b
    SwitchGear 3'UTR luciferase reporter plasmidRHOV 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RHOV
    Predesigned siRNA for gene silencing in human, mouse, rat RHOV
    Clone
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    OriGene clones in human, mouse for RHOV (see all 5)
    OriGene ORF clones in mouse, rat for RHOV
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RHOV (NM_133639)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOV
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOV
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOV
      QuantiTect SYBR Green Assays in human, mouse, rat RHOV
      QuantiFast Probe-based Assays in human, mouse, rat RHOV

    Additional mRNA sequence: 

    AB079131.1 AY059636.1 BC019353.1 BC105020.1 BC105022.1 BC112945.1 

    3 DOTS entries:

    DT.428432  DT.95367590  DT.95330936 

    Selected AceView cDNA sequences (see all 29):

    CR618466 NM_133639 CR615243 AB079131 BX357883 AI690344 CR599960 AY059636 
    BX357884 BE076026 AA367838 BC019353 BX377326 BE794346 CB851513 D78924 
    BG290065 BX344621 AW514309 BX365623 BE547917 AA339401 BI193105 BF747335 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOV expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGGTCCT
    RHOV Expression
    About this image


    RHOV expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Hindgut
     
     Esophagus (Gastrointestinal Tract)
    RHOV Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOV Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.447901

    UniProtKB/Swiss-Prot: RHOV_HUMAN, Q96L33
    Tissue specificity: Highly expressed in pancreas, placenta, and fetal brain

        Pathway & Disease-focused RT2 Profiler PCR Array including RHOV: 
              Notch Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOV
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOV
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RHOV gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhov1 , 5 ras homolog gene family, member V1, 5 89.55(n)1
    99.15(a)1
      2 (59.97 cM)5
    2285431  NM_145530.21  NP_663505.11 
     1192692015 
    chicken
    (Gallus gallus)
    Aves RHOV1 ras homolog family member V 78.1(n)
    84.06(a)
      428868  XM_426425.3  XP_426425.2 
    lizard
    (Anolis carolinensis)
    Reptilia RHOV6
    ras homolog family member V
    81(a)
    1 ↔ 1
    GL343264.1(221330-336666)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24342 Xenopus laevis transcribed sequence with weak similarity more 75.98(n)    48047737 
    zebrafish
    (Danio rerio)
    Actinopterygii rhov1 ras homolog gene family, member V 63.61(n)
    65.22(a)
      100005849  NM_001012250.2  NP_001012250.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG341046
    --
    17(a)
    1 → many
    X(9980566-10042911)
    worm
    (Caenorhabditis elegans)
    Secernentea chw-16
    Protein CHW-1 (chw-1) mRNA, complete cds
    47(a)
    1 → many
    V(10462282-10464660) WBGene00009059


    ENSEMBL Gene Tree for RHOV (if available)
    TreeFam Gene Tree for RHOV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOV gene
    RHOH2  RHOQ2  RHOBTB12  RHOU2  RHOG2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    Selected SIMAP similar genes for RHOV using alignment to 2 protein entries:     RHOV_HUMAN (see all proteins) (see all similar genes):
    CDC42    RAC2    RAC3    ARHG    RHOG    RAC1
    RHOA    RHOB    RHOD    RHOQ    RHOC    RHOJ
    RHOU    RHOH    ARHH    ARHA    RAB37    ARHE

    Find genes that share paralogs with RHOV           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOV (see all 72)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740118961,2
    C,F--41163969(+) CGGAGA/G/TGGGGG 1 -- int12WA 120
    rs793009321,2
    F--41164205(+) CCTGGG/TAACCA 1 -- int10--------
    rs22795781,2
    C,F,H--41164344(+) CCAGGT/CAGTTA 1 -- int123Minor allele frequency- C:0.44EA NS NA CSA WA 3826
    rs355796731,2
    C--41164678(+) GCCCAG/AGTGTC 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs1866312481,2
    --41164715(+) CCTCTC/TTCCTC 1 -- ut310--------
    rs734005451,2
    C--41164805(+) TCTCTC/TGCCCA 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1918341531,2
    --41164910(+) AGGAAC/GGGTCC 1 -- ut310--------
    rs1846356601,2
    --41165192(+) GGCCCA/GGGTGC 1 -- ut310--------
    rs2010471491,2
    --41165206(+) AGGTCA/TCAGAA 1 -- ut310--------
    rs1119088771,2
    C,F--41165233(+) CTACTA/GCTTGC 1 -- ut311Minor allele frequency- G:0.01EU 593

    HapMap Linkage Disequilibrium report for RHOV (41164412 - 41166487 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RHOV:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2360n71CNV Loss21882294
    nsv904102CNV Loss21882294
    nsv904104CNV Loss21882294
    nsv904101CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOV
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOV

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOV gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with RHOV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Rho GTPase family: a Racs to Wrchs story. (PubMed id 11839775)1, 2, 3 Wherlock M. and Mellor H. (J. Cell Sci. 2002)
    2. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. (PubMed id 11956592)1, 2, 9 Katoh M. (Int. J. Oncol. 2002)
    3. Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV. (PubMed id 22339630)1 Shepelev M.V. and Korobko I.V. (Biochemistry Mosc. 2012)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp. (PubMed id 17355222)1 Weisz Hubsman M....Aronheim A. (Biochem. J. 2007)
    7. Evolution of the Rho family of ras-like GTPases in eukaryotes. (PubMed id 17035353)1 Boureux A....Fort P. (Mol. Biol. Evol. 2007)
    8. Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins. (PubMed id 16752908)1 Liu J....Song J. (Biochemistry 2006)
    9. Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. (PubMed id 15664990)1 Chenette E.J....Der C.J. (J. Biol. Chem. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 171177 HGNC: 18313 AceView: RHOV Ensembl:ENSG00000104140 euGenes: HUgn171177
    ECgene: RHOV H-InvDB: RHOV

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHOV Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHOV gene:
    Search GeneIP for patents involving RHOV

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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