Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RHOV Gene

Aliases for RHOV Gene

  • Ras Homolog Family Member V 2 3 5
  • Ras Homolog Gene Family, Member V 2 3
  • Wnt-1 Responsive Cdc42 Homolog 2 3 4
  • Rho GTPase-Like Protein ARHV 3 4
  • GTP-Binding Protein-Like 2 3 4
  • CDC42-Like GTPase 2 3 4
  • WRCH-2 3 4
  • WRCH2 3 4
  • ARHV 3 4
  • Wnt-1 Regulated Cdc42 Homolog 2 3
  • WRCH1-Related GTPase 3
  • CHP 3

External Ids for RHOV Gene

Previous HGNC Symbols for RHOV Gene

  • ARHV

Previous GeneCards Identifiers for RHOV Gene

  • GC15M038881
  • GC15M038952
  • GC15M041164
  • GC15M018012

Summaries for RHOV Gene

GeneCards Summary for RHOV Gene

RHOV (Ras Homolog Family Member V) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTP binding. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOV Gene

  • Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOV Gene

Genomics for RHOV Gene

Regulatory Elements for RHOV Gene

Promoters for RHOV Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHOV on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOV Gene

Chromosome:
15
Start:
40,872,214 bp from pter
End:
40,874,289 bp from pter
Size:
2,076 bases
Orientation:
Minus strand

Genomic View for RHOV Gene

Genes around RHOV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOV Gene

Proteins for RHOV Gene

  • Protein details for RHOV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96L33-RHOV_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoV
    Protein Accession:
    Q96L33
    Secondary Accessions:
    • Q2KHQ5
    • Q8TDW6

    Protein attributes for RHOV Gene

    Size:
    236 amino acids
    Molecular mass:
    26217 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PAK2.

neXtProt entry for RHOV Gene

Proteomics data for RHOV Gene at MOPED

Post-translational modifications for RHOV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOV Gene

Domains & Families for RHOV Gene

Gene Families for RHOV Gene

Suggested Antigen Peptide Sequences for RHOV Gene

Graphical View of Domain Structure for InterPro Entry

Q96L33

UniProtKB/Swiss-Prot:

RHOV_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOV: view

Function for RHOV Gene

Molecular function for RHOV Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway.

Gene Ontology (GO) - Molecular Function for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16752908
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOV: view
genes like me logo Genes that share phenotypes with RHOV: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOV Gene

Localization for RHOV Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOV Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Endosome membrane; Lipid-anchor; Cytoplasmic side. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250 UniProtKB:Q9Z1Y0}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOV Gene COMPARTMENTS Subcellular localization image for RHOV gene
Compartment Confidence
cytosol 5
plasma membrane 4
endosome 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RHOV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOV: view

Pathways & Interactions for RHOV Gene

genes like me logo Genes that share pathways with RHOV: view

Pathways by source for RHOV Gene

Gene Ontology (GO) - Biological Process for RHOV Gene

None

No data available for SIGNOR curated interactions for RHOV Gene

Drugs & Compounds for RHOV Gene

(1) Drugs for RHOV Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with RHOV: view

Transcripts for RHOV Gene

mRNA/cDNA for RHOV Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOV Gene

Ras homolog family member V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOV Gene

No ASD Table

Relevant External Links for RHOV Gene

GeneLoc Exon Structure for
RHOV
ECgene alternative splicing isoforms for
RHOV

Expression for RHOV Gene

mRNA expression in normal human tissues for RHOV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOV Gene

This gene is overexpressed in Esophagus - Mucosa (x14.4), Skin - Sun Exposed (Lower leg) (x9.2), Skin - Not Sun Exposed (Suprapubic) (x9.0), and Vagina (x5.6).

SOURCE GeneReport for Unigene cluster for RHOV Gene Hs.447901

mRNA Expression by UniProt/SwissProt for RHOV Gene

Q96L33-RHOV_HUMAN
Tissue specificity: Highly expressed in pancreas, placenta, and fetal brain.
genes like me logo Genes that share expression patterns with RHOV: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RHOV Gene

Orthologs for RHOV Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOV 35
  • 99.44 (n)
  • 100 (a)
RHOV 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOV 35
  • 92.23 (n)
  • 97.03 (a)
RHOV 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOV 35
  • 93.22 (n)
  • 98.31 (a)
RHOV 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhov 16
Rhov 36
  • 99 (a)
OneToOne
Rhov 35
  • 89.55 (n)
  • 99.15 (a)
oppossum
(Monodelphis domestica)
Mammalia RHOV 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOV 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhov 35
  • 90.54 (n)
  • 98.31 (a)
chicken
(Gallus gallus)
Aves RHOV 36
  • 80 (a)
OneToOne
RHOV 35
  • 78.1 (n)
  • 84.06 (a)
lizard
(Anolis carolinensis)
Reptilia RHOV 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2434 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15841 35
rhov 35
  • 72.3 (n)
  • 77.78 (a)
zebrafish
(Danio rerio)
Actinopterygii rhov 36
  • 59 (a)
OneToOne
rhov 35
  • 63.61 (n)
  • 65.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34104 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea chw-1 36
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9013 36
  • 50 (a)
OneToMany
Species with no ortholog for RHOV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOV Gene

ENSEMBL:
Gene Tree for RHOV (if available)
TreeFam:
Gene Tree for RHOV (if available)

Paralogs for RHOV Gene

Paralogs for RHOV Gene

genes like me logo Genes that share paralogs with RHOV: view

Variants for RHOV Gene

Sequence variations from dbSNP and Humsavar for RHOV Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2279578 -- 40,872,146(+) CCAGG(C/T)AGTTA downstream-variant-500B
rs3803351 -- 40,873,564(-) GCCCC(A/G)GGTGA intron-variant
rs12903260 -- 40,875,918(+) ccacc(A/C)cgccc upstream-variant-2KB
rs34122473 -- 40,874,892(+) AGCCG(-/A)AAATC upstream-variant-2KB
rs35579673 -- 40,872,480(+) GCCCA(A/G)GTGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RHOV Gene

Variant ID Type Subtype PubMed ID
nsv904101 CNV Loss 21882294
nsv904102 CNV Loss 21882294
dgv2360n71 CNV Loss 21882294
nsv904104 CNV Loss 21882294

Variation tolerance for RHOV Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOV Gene

HapMap Linkage Disequilibrium report
RHOV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOV Gene

Disorders for RHOV Gene

Relevant External Links for RHOV

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOV

No disorders were found for RHOV Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOV Gene

Publications for RHOV Gene

  1. The Rho GTPase family: a Racs to Wrchs story. (PMID: 11839775) Wherlock M. … Mellor H. (J. Cell Sci. 2002) 2 3 4 67
  2. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. (PMID: 11956592) Katoh M. (Int. J. Oncol. 2002) 3 23
  3. The RHOV gene is overexpressed in human non-small cell lung cancer. (PMID: 24388711) Shepelev M.V. … Korobko I.V. (Cancer Genet 2013) 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV. (PMID: 22339630) Shepelev M.V. … Korobko I.V. (Biochemistry Mosc. 2012) 3

Products for RHOV Gene

Sources for RHOV Gene

Back to Top

Content