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Aliases for RHOU Gene

Aliases for RHOU Gene

  • Ras Homolog Family Member U 2 3 5
  • Ryu GTPase 2 3 4
  • Ras Homolog Gene Family, Member U 2 3
  • Wnt-1 Responsive Cdc42 Homolog 1 3 4
  • Ras-Like Gene Family Member U 2 3
  • Rho GTPase-Like Protein ARHU 3 4
  • GTP-Binding Protein Like 1 2 3
  • GTP-Binding Protein SB128 2 3
  • CDC42-Like GTPase 1 3 4
  • 2310026M05Rik 2 3
  • CDC42L1 3 4
  • WRCH1 3 4
  • ARHU 3 4
  • G28K 3 4
  • Rho-Related GTP-Binding Protein RhoU 3
  • Wnt-1 Responsive Cdc42 Homolog 2
  • GTP-Binding Protein-Like 1 4
  • CDC42-Like GTPase 2
  • WRCH-1 4
  • HG28K 3

External Ids for RHOU Gene

Previous HGNC Symbols for RHOU Gene

  • ARHU

Previous GeneCards Identifiers for RHOU Gene

  • GC01P225833
  • GC01P225177
  • GC01P226937
  • GC01P228870
  • GC01P199361
  • GC01P228785

Summaries for RHOU Gene

Entrez Gene Summary for RHOU Gene

  • This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]

GeneCards Summary for RHOU Gene

RHOU (Ras Homolog Family Member U) is a Protein Coding gene. Among its related pathways are Innate Immune System and Interleukin-4 and 13 signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOV.

UniProtKB/Swiss-Prot for RHOU Gene

  • Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOU Gene

Genomics for RHOU Gene

Regulatory Elements for RHOU Gene

Enhancers for RHOU Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G228646 1.8 FANTOM5 Ensembl ENCODE 11 +3.4 3391 2.8 HDGF ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF207 NUP133 CICP26 C1orf35 ENSG00000269890 HMGN2P19 HIST3H3 TAF5L ABCB10 RHOU JMJD4
GH01G228781 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +138.4 138416 3.7 FOXA2 ARID4B FEZF1 ZNF2 ZNF302 ZNF416 FOS ZNF263 REST KAT8 NUP133 CICP26 C1orf35 ENSG00000269890 TAF5L ABCB10 HMGN2P19 ENSG00000231563 TMEM78 HIST3H3
GH01G229064 1.5 Ensembl ENCODE dbSUPER 4.5 +419.9 419938 0.9 FOXA2 ATF1 ARID4B ZNF48 ZNF766 SP5 PPARG KAT8 RCOR2 ETV4 RHOU ISCA1P2 GC01M229181
GH01G229091 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.9 +448.7 448745 3.9 HDGF FOXA2 PKNOX1 ARNT FEZF1 ZNF2 YY1 ZNF143 FOS ZNF263 NUP133 ENSG00000269890 URB2 C1orf35 HIST3H3 ENSG00000226920 ENSG00000269934 HMGN2P19 TMEM78 RHOU
GH01G229198 1.4 FANTOM5 Ensembl ENCODE 3.4 +555.1 555149 2.4 NFIB RAD21 ZEB1 ZNF766 RCOR1 SMARCC1 ZNF280D ZBTB11 ZHX2 ELF1 LOC105373158 ENSG00000233920 NUP133 TMEM78 ACTA1 RHOU CCSAP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOU on UCSC Golden Path with GeneCards custom track

Promoters for RHOU Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000257141 -547 601 ZFP64 ZBTB20

Genomic Location for RHOU Gene

Chromosome:
1
Start:
228,644,647 bp from pter
End:
228,746,669 bp from pter
Size:
102,023 bases
Orientation:
Plus strand

Genomic View for RHOU Gene

Genes around RHOU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOU Gene

Proteins for RHOU Gene

  • Protein details for RHOU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L0Q8-RHOU_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoU
    Protein Accession:
    Q7L0Q8
    Secondary Accessions:
    • B1AKN1
    • Q59FE9
    • Q8TDQ2

    Protein attributes for RHOU Gene

    Size:
    258 amino acids
    Molecular mass:
    28218 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PAK3. Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation, interacts with ARHGAP31. Interacts with PTK2B/PYK2.

    Three dimensional structures from OCA and Proteopedia for RHOU Gene

    Alternative splice isoforms for RHOU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOU Gene

Post-translational modifications for RHOU Gene

  • Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOU Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOU Gene

Domains & Families for RHOU Gene

Gene Families for RHOU Gene

Protein Domains for RHOU Gene

Suggested Antigen Peptide Sequences for RHOU Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L0Q8

UniProtKB/Swiss-Prot:

RHOU_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOU: view

Function for RHOU Gene

Molecular function for RHOU Gene

UniProtKB/Swiss-Prot Function:
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Gene Ontology (GO) - Molecular Function for RHOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 14521508
GO:0005525 GTP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RHOU: view
genes like me logo Genes that share phenotypes with RHOU: view

Animal Models for RHOU Gene

MGI Knock Outs for RHOU:
  • Rhou tm1a(KOMP)Wtsi

Animal Model Products

CRISPR Products

miRNA for RHOU Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOU
  • Applied Biological Materials Clones for RHOU

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOU Gene

Localization for RHOU Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOU Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells. {ECO:0000269 PubMed:16046391, ECO:0000269 PubMed:16472646, ECO:0000269 PubMed:17620058}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOU gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 4
golgi apparatus 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RHOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0002102 podosome IEA --
GO:0005622 intracellular IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RHOU: view

Pathways & Interactions for RHOU Gene

genes like me logo Genes that share pathways with RHOU: view

Gene Ontology (GO) - Biological Process for RHOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008360 regulation of cell shape IMP 21834987
GO:0016601 Rac protein signal transduction IEA --
genes like me logo Genes that share ontologies with RHOU: view

No data available for SIGNOR curated interactions for RHOU Gene

Drugs & Compounds for RHOU Gene

(4) Drugs for RHOU Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Magnesium Nutra 0
genes like me logo Genes that share compounds with RHOU: view

Transcripts for RHOU Gene

mRNA/cDNA for RHOU Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(209) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOU Gene

Ras homolog family member U:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RHOU
  • Applied Biological Materials Clones for RHOU

Alternative Splicing Database (ASD) splice patterns (SP) for RHOU Gene

No ASD Table

Relevant External Links for RHOU Gene

GeneLoc Exon Structure for
RHOU
ECgene alternative splicing isoforms for
RHOU

Expression for RHOU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RHOU Gene

Protein differential expression in normal tissues from HIPED for RHOU Gene

This gene is overexpressed in Tlymphocyte (22.8), Monocytes (17.0), Pancreas (16.3), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RHOU Gene



Protein tissue co-expression partners for RHOU Gene

NURSA nuclear receptor signaling pathways regulating expression of RHOU Gene:

RHOU

SOURCE GeneReport for Unigene cluster for RHOU Gene:

Hs.647774

mRNA Expression by UniProt/SwissProt for RHOU Gene:

Q7L0Q8-RHOU_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.

Evidence on tissue expression from TISSUES for RHOU Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with RHOU: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RHOU Gene

Orthologs for RHOU Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOU 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOU 34 35
  • 92.64 (n)
cow
(Bos Taurus)
Mammalia RHOU 34 35
  • 87.58 (n)
mouse
(Mus musculus)
Mammalia Rhou 34 16 35
  • 86.12 (n)
oppossum
(Monodelphis domestica)
Mammalia RHOU 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOU 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOU 34 35
  • 84.99 (n)
lizard
(Anolis carolinensis)
Reptilia RHOU 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rhou 34
  • 66.99 (n)
Str.181 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4621 34
zebrafish
(Danio rerio)
Actinopterygii rhoua 34 35
  • 74.88 (n)
rhoub 35
  • 65 (a)
OneToMany
RHOU (1 of 3) 35
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1184 34
fruit fly
(Drosophila melanogaster)
Insecta CG34104 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea chw-1 35
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9013 35
  • 55 (a)
OneToMany
Species where no ortholog for RHOU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOU Gene

ENSEMBL:
Gene Tree for RHOU (if available)
TreeFam:
Gene Tree for RHOU (if available)

Paralogs for RHOU Gene

Paralogs for RHOU Gene

(22) SIMAP similar genes for RHOU Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RHOU: view

Variants for RHOU Gene

Sequence variations from dbSNP and Humsavar for RHOU Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000014968 -- 228,733,755(+) GGTCA(C/T)AGGTA intron-variant, upstream-variant-2KB
rs1000032588 -- 228,690,720(+) TCAAG(C/T)GATTC intron-variant
rs1000070948 -- 228,684,367(+) ATGTG(G/T)CATCC intron-variant
rs1000094259 -- 228,647,265(+) TTTCT(G/T)GGCAC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000136955 -- 228,674,276(+) CTCTT(A/G)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOU Gene

Variant ID Type Subtype PubMed ID
dgv287n106 CNV duplication 24896259
dgv288n106 CNV deletion 24896259
esv1454255 CNV deletion 17803354
esv24714 CNV gain+loss 19812545
esv2678504 CNV deletion 23128226
esv2724395 CNV deletion 23290073
esv2724406 CNV deletion 23290073
esv2762224 CNV gain 21179565
esv32853 CNV gain 17666407
esv3547900 CNV deletion 23714750
esv3589053 CNV gain 21293372
esv3589054 CNV loss 21293372
esv3589055 CNV loss 21293372
esv3589057 CNV loss 21293372
esv3891181 CNV gain 25118596
esv6055 CNV loss 19470904
nsv1009511 CNV gain 25217958
nsv1013500 CNV gain 25217958
nsv1069364 CNV deletion 25765185
nsv1075809 CNV duplication 25765185
nsv1127064 CNV deletion 24896259
nsv1150538 CNV deletion 26484159
nsv509635 CNV insertion 20534489
nsv511020 OTHER complex 20534489
nsv511738 CNV loss 21212237
nsv549299 CNV gain 21841781
nsv549300 CNV loss 21841781
nsv827075 CNV loss 20364138
nsv945355 CNV duplication 23825009
nsv945357 CNV duplication 23825009
nsv952144 CNV duplication 24416366
nsv957478 CNV deletion 24416366
nsv998255 CNV gain 25217958

Variation tolerance for RHOU Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOU Gene

Disorders for RHOU Gene

Relevant External Links for RHOU

Genetic Association Database (GAD)
RHOU
Human Genome Epidemiology (HuGE) Navigator
RHOU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOU

No disorders were found for RHOU Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOU Gene

Publications for RHOU Gene

  1. The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. (PMID: 18086875) Ruusala A. … Aspenstrom P. (Mol. Cell. Biol. 2008) 3 4 22 64
  2. Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. (PMID: 11894124) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2002) 3 4 22 64
  3. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. (PMID: 11459829) Tao W. … Levine A.J. (Genes Dev. 2001) 2 3 4 64
  4. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PMID: 21565175) Naji L. … Aspenstrom P. (Biochem. Biophys. Res. Commun. 2011) 3 4 64
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64

Products for RHOU Gene

  • Addgene plasmids for RHOU

Sources for RHOU Gene

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