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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RHOU Gene

protein-coding GIFtS: 53
GCID: GC01P228870

ras homolog family member U

(Previous names: ras homolog gene family, member U )
(Previous symbol: ARHU)

Explore 7 diseases affiliated with
RHOU via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ras Homolog Family Member U¹ ²		CDC42-Like GTPase 1² ³
WRCH1¹ ² ³ ⁵		Ryu GTPase² ³
ARHU¹ ² ³		FLJ10616¹
CDC42L1¹ ² ³		2310026M05Rik²
DJ646B12.2¹ ²		GTP-Binding Protein Like 1²
FJ646B12.2¹		GTP-Binding Protein SB128²
HG28K¹		Ras-Like Gene Family Member U²
Ras Homolog Gene Family, Member U¹ ²		Rho-Related GTP-Binding Protein RhoU²
WRCH-1¹ ³		G28K³
Rho GTPase-Like Protein ARHU² ³		GTP-Binding Protein-Like 1³
Wnt-1 Responsive Cdc42 Homolog 1² ³

External Ids:	HGNC: 17794¹	Entrez Gene: 58480²	Ensembl: ENSG00000116574⁷	OMIM: 606366⁵	UniProtKB: Q7L0Q8³

Export aliases for RHOU gene to outside databases

Previous GC identifers: GC01P225833 GC01P225177 GC01P226937 GC01P199361

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOU:

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce

filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation

of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene

results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual

specificity phosphatase 5 pseudogene) locus.(provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8

Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration.

Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine

nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell

morphology and cytoskeletal organization. Required in the control of cell shape

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHOU gene promoter:
Nkx2-5 MIF-1 Nkx5-1 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHOU promoter sequence

Search SABiosciences Chromatin IP Primers for RHOU

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOU

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.11-q42.3 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.11-q42.3

RHOU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOU gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P228870: view genomic region (about GC identifiers)

Start:	228,870,824 bp from pter	End:	228,882,416 bp from pter
Size:	11,593 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8 (See protein sequence)

Recommended Name: Rho-related GTP-binding protein RhoU

Size: 258 amino acids; 28218 Da

Cofactor: Magnesium

Subunit: Interacts with PAK3. Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation,

interacts with ARHGAP31. Interacts with PTK2B/PYK2

Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell

junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells

1 PDB 3D structure from and Proteopedia for RHOU:

2Q3H (3D)

Secondary accessions: B1AKN1 Q59FE9 Q8TDQ2

Alternative splicing: 2 isoforms: Q7L0Q8-1 Q7L0Q8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHOU: NX_Q7L0Q8

Post-translational modifications:

Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7L0Q8

RHOU Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_067028.1

ENSEMBL proteins:

ENSP00000355652

Reactome Protein details: Q7L0Q8
Human Recombinant Protein Products for RHOU:

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	Uscn Proteins for RHOU

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0002102	podosome	IEA	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0005925	focal adhesion	IEA	--

RHOU for ontologies About GeneDecksing

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Assay Products for RHOU:

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	Uscn ELISAs and CLIAs for RHOU

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RHOU for domains About GeneDecksing

3 InterPro domains/families:

IPR003578 Small_GTPase_Rho

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

Graphical View of Domain Structure for InterPro Entry Q7L0Q8

ProtoNet protein and cluster: Q7L0Q8

UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8

Similarity: Belongs to the small GTPase superfamily. Rho family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RHOU_HUMAN, Q7L0Q8

Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration.

Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine

nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell

morphology and cytoskeletal organization. Required in the control of cell shape

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005515	protein binding	IPI	18086875
GO:0005525	GTP binding	IEA	--
GO:0046872	metal ion binding	IEA	--

RHOU for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for RHOU:

Decreased focal adhesion (FA)

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RHOU

miRNA Products:		OriGene 3'-UTR Clone: RHOU Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOU
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOU (see all 26):
		hsa-miR-498 hsa-miR-3910 hsa-miR-140-5p hsa-miR-607 hsa-miR-562 hsa-miR-448 hsa-miR-938 hsa-miR-520a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RHOU 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOU

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for RHOU

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

RHOU for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RHOU

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/87 Interacting proteins for RHOU (Q7L0Q8^{1, 2, 3} ENSP00000355652⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 87)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAK1	Q13153²^,³, ENSP00000278568⁴	MINT-50674 MINT-7300795 MINT-50675 I2D: score=3 STRING: ENSP00000278568
PLCG1	P19174²^,³, ENSP00000244007⁴	MINT-50686 MINT-50690 I2D: score=1 STRING: ENSP00000244007
PTK2B	Q14289¹^,³, ENSP00000332816⁴	EBI-1638043,EBI-2211226 I2D: score=1 STRING: ENSP00000332816
NCK2	O43639¹^,²^,³, ENSP00000233154⁴	EBI-1638043,EBI-713635 MINT-7300813 MINT-7300841 MINT-7136617 MINT-7136730 MINT-7300769 I2D: score=2 STRING: ENSP00000233154
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-50683 MINT-50677 MINT-50684 I2D: score=1 STRING: ENSP00000339007

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IEA	--
GO:0006184	GTP catabolic process	--	--
GO:0007010	cytoskeleton organization	IMP	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0008360	regulation of cell shape	IMP	--

RHOU for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RHOU

4 HMDB Compounds for RHOU About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about RHOU

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RHOU gene:

NM_021205.5

Unigene Cluster for RHOU:

Ras homolog family member U

Hs.647774 [show with all ESTs]

Unigene Representative Sequence: NM_021205

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366691(uc021pkj.1 uc001htf.3) ENST00000473307 ENST00000493528

miRNA Products:		OriGene 3'-UTR Clone: RHOU Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOU
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOU (see all 26):
		hsa-miR-498 hsa-miR-3910 hsa-miR-140-5p hsa-miR-607 hsa-miR-562 hsa-miR-448 hsa-miR-938 hsa-miR-520a-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RHOU 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOU (see all 4) OriGene shRNA RFP: RHOU OriGene siRNA: RHOU
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		Sirion Biotech Custom design and validation of potent shRNA sequences against RHOU

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOU (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOU (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AB051826.1 AB074878.1 AB209511.1 AF211836.1 AF251701.1 AF282258.1 AF378087.1 AK001478.1

AK289971.1 BC040076.1 NR_037962.1

10 DOTS entries:

DT.448447 DT.91750861 DT.121336282 DT.100721117 DT.75103516 DT.100784280 DT.100784286 DT.121350137

DT.121430106 DT.121336270

24/209 AceView cDNA sequences (see all 209):

BG565410 BC040076 BX100860 AA602716 CN478603 AA503364 AI057486 AI124646

F01671 AA923007 NM_021205 AI471090 BP380012 AA700701 AW594430 AB051826

AI382139 BM717858 AI687503 AU120225 N77681 CR616242 BF725546 Z39926

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHOU expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTATAAA

About this image

RHOU expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Foregut

Foregut Endoderm Cells

Endoderm

Gut Tube

Ventral Foregut Endoderm

Ventral Foregut Endoderm Cells

Endoderm

Liver

Liver Bud

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Nkx2-1 GFP+ cells (Efficient derivation...)

See RHOU Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHOU

SOURCE GeneReport for Unigene cluster: Hs.647774

UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8

Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small

intestine, brain, skeletal muscle and placenta

SABiosciences Expression via Pathway-Focused PCR Array including RHOU:

WNT Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOU

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOU gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RHOU¹	ras homolog gene family, member U	84.71(n) 98.82(a)		428589 XM_426146.3 XP_426146.3
lizard (Anolis carolinensis)	Reptilia	RHOU⁶ --	--	81(a) 40(a)	1 ↔ 1 possible ortholog	1(221813723-221825816) LGf(2834170-2834710)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4621²	Xenopus laevis transcribed sequence with weak similarity more	76.99(n)		48053146
zebrafish (Danio rerio)	Actinopterygii	rhoua¹	ras homolog gene family, member Ua	70.27(n) 74.8(a)		492802 NM_001007443.1 NP_001007444.1
fruit fly (Drosophila melanogaster)	Insecta	CG34104⁶	--	15(a)	possible ortholog	X(9980566-10042911)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATROP6⁶ ROP1⁶ (see all 11)	Rac-like GTP-binding protein ARAC11 (see all 11)	49(a) 48(a) (see all 11)	many ↔ many many ↔ many (see all 11)	4(16672192-16674771) 3(19042887-19044372)
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	ras-related protein, putative, expressed (see all 9)	49(a) 48(a) (see all 9)	many ↔ many many ↔ many (see all 9)	2(35874978-35879805) 2(1080513-1084283)

ENSEMBL Gene Tree for RHOU (if available)
TreeFam Gene Tree for RHOU (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RHOU gene

RHOH² RHOQ² RHOBTB1² RHOV² RHOG² RHOBTB2² RAC1² RAC2²

CDC42² RHOJ² RAC3²

18/22 SIMAP similar genes for RHOU using alignment to 1 protein entry: RHOU_HUMAN(see all similar genes):

CDC42 RHOA RHOC RHOQ RAC2 ARHG

RHOB RHOG RHOJ RAC3 RAC1 RHOV

RHOD ARHH RHOH ARHE RND3 RND2

RHOU for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73109076^1,2	C	--	199274680(+)	`CATCCT/GGAATA`	10	--	us2k¹		2		WA	120
rs200475093^1,2	C	--	199274915(+)	`GCTTAG/TCNNNN`	10	--	us2k¹		0	--	--	--	--
rs138341044^1,2		--	228782470(+)	`AGGAGC/GAAATC`	3	--	int¹ us2k¹		0	--	--	--	--
rs149635580^1,2		--	228782484(+)	`TCCCCC/TACACA`	3	--	us2k¹ int¹		0	--	--	--	--
rs183722188^1,2		--	228782497(+)	`GACACA/TCCCGT`	3	--	int¹ us2k¹		0	--	--	--	--
rs147308786^1,2		--	228782508(+)	`TCGTTC/GTCGTT`	3	--	int¹ us2k¹		0	--	--	--	--
rs35724040^1,2	C,F	--	228782519(+)	`CCGGAA/TCCCGC`	3	--	us2k¹ int¹		5		NA WA EA	362
rs187648691^1,2		--	228782532(+)	`GCGAGC/TACGGG`	3	--	int¹ us2k¹		0	--	--	--	--
rs113614567^1,2		--	228782534(+)	`GAGCAC/TGGGTG`	3	--	int¹ us2k¹		1		CSA	2
rs184298458^1,2		--	228782539(+)	`CGGGTG/TCGCAG`	3	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RHOU (228870824 - 228882416 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RHOU: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RHOU for disorders           About GeneDecksing

OMIM gene information: 606366    OMIM disorders: --

7 diseases for RHOU:    About MalaCards

denture stomatitis basal cell carcinoma stomatitis endometriosis

pharyngitis melanoma carcinoma

1 disease from the University of Copenhagen DISEASES database for RHOU:

Denture stomatitis

Human Genome Epidemiology (HuGE) Navigator: RHOU (1 document)

Export disorders for RHOU gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RHOU gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with RHOU)

Utopia: connect your pdf to the dynamic
world of online information

Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. (PubMed id 11459829)^{1, 2, 3} Tao W.... Levine A.J. (2001)
Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. (PubMed id 11894124)^{1, 2, 9} Kirikoshi H. and Katoh M. (2002)
The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. (PubMed id 18086875)^{1, 2, 9} Ruusala A. and Aspenstrom P. (2008)
ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PubMed id 21565175)^{1, 2} Naji L.... Aspenstrom P. (2011)
Scan of human genome reveals no new loci under ancient balancing selection. (PubMed id 16751668)^{1, 2} Bubb K.L.... Olson M.V. (2006)
Novel human, mouse and xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum. (PubMed id 14731133)^{1, 2} Daigo Y.... Fujino M.A. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Linkage and association of successful aging to the 6q2 5 region in large Amish kindreds. (PubMed id 22773346)¹ Edwards D.R....Scott W.K. (2012)
GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration. (PubMed id 21508312)¹ Zhang J.S....Billadeau D.D. (2011)
Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)² Bai S.W.... Ridley A.J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 58480	HGNC: 17794	AceView: RHOU	Ensembl:ENSG00000116574	euGenes: HUgn58480
ECgene: RHOU	H-InvDB: RHOU

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RHOU	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RHOU gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RHOU gene:
Search GeneIP for patents involving RHOU

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

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ras homolog family member U

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RHOU (Gene Symbol)
Ras Homolog Family Member U
WRCH1
ARHU
CDC42L1
DJ646B12.2
FJ646B12.2
HG28K
Ras Homolog Gene Family, Member U
WRCH-1
Rho GTPase-Like Protein ARHU
Wnt-1 Responsive Cdc42 Homolog 1
CDC42-Like GTPase 1
Ryu GTPase
FLJ10616
2310026M05Rik
GTP-Binding Protein Like 1
GTP-Binding Protein SB128
Ras-Like Gene Family Member U
Rho-Related GTP-Binding Protein RhoU
G28K
GTP-Binding Protein-Like 1

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RHOU Gene

ras homolog family member U

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