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RHOU Gene

protein-coding   GIFtS: 56
GCID: GC01P228785

Ras Homolog Family Member U

(Previous names: ras homolog gene family, member U)
(Previous symbol: ARHU)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member U1 2     CDC42L12 3
ARHU1 2 3     CDC42-Like GTPase 12 3
Ryu GTPase1 2 3     CDC42-Like GTPase1
WRCH12 3 5     Wnt-1 Responsive Cdc42 Homolog1
Ras Homolog Gene Family, Member U1 2     DJ646B12.22
2310026M05Rik1 2     fJ646B12.22
GTP-Binding Protein Like 11 2     hG28K2
GTP-Binding Protein SB1281 2     Rho-Related GTP-Binding Protein RhoU2
Ras-Like Gene Family Member U1 2     G28K3
Rho GTPase-Like Protein ARHU2 3     WRCH-13
Wnt-1 Responsive Cdc42 Homolog 12 3     GTP-Binding Protein-Like 13

External Ids:    HGNC: 177941   Entrez Gene: 584802   Ensembl: ENSG000001165747   OMIM: 6063665   UniProtKB: Q7L0Q83   

Export aliases for RHOU gene to outside databases

Previous GC identifers: GC01P225833 GC01P225177 GC01P226937 GC01P228870 GC01P199361


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RHOU Gene:
This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce
filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the
regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant
of this gene results from naturally occurring read-through transcription between this locus and the neighboring
DUSP5P (dual specificity phosphatase 5 pseudogene) locus.(provided by RefSeq, Mar 2011)

GeneCards Summary for RHOU Gene:
RHOU (ras homolog family member U) is a protein-coding gene. Diseases associated with RHOU include denture stomatitis, and stomatitis. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8
Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration.
Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic
guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of
cell morphology and cytoskeletal organization. Required in the control of cell shape




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOU gene promoter:
         Nkx2-5   MIF-1   Nkx5-1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOU promoter sequence
   Search Chromatin IP Primers for RHOU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.11-q42.3   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.11-q42.3

RHOU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOU gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P228785:  view genomic region     (about GC identifiers)

Start:
228,780,394 bp from pter      End:
228,882,416 bp from pter
Size:
102,023 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RHOU

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoU  
Size: 258 amino acids; 28218 Da
Cofactor: Magnesium
Subunit: Interacts with PAK3. Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation,
interacts with ARHGAP31. Interacts with PTK2B/PYK2
1 PDB 3D structure from and Proteopedia for RHOU:
2Q3H (3D)    
Secondary accessions: B1AKN1 Q59FE9 Q8TDQ2
Alternative splicing: 2 isoforms:  Q7L0Q8-1   Q7L0Q8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHOU: NX_Q7L0Q8

Explore proteomics data for RHOU at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RHOU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067028.1  
    ENSEMBL proteins: 
     ENSP00000355652  
    Reactome Protein details: Q7L0Q8

    RHOU Human Recombinant Protein Products:

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    RHOU Assay Products:

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    Cloud-Clone Corp. CLIAs for RHOU


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q7L0Q8

    ProtoNet protein and cluster: Q7L0Q8

    UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOU_HUMAN, Q7L0Q8
    Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration.
    Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic
    guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of
    cell morphology and cytoskeletal organization. Required in the control of cell shape

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI14521508
    GO:0005525GTP binding IEA--
    GO:0046872metal ion binding IEA--
         
    RHOU for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RHOU:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RHOU
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RHOU

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOU
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOU

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOU:
    hsa-mir-374b-5p (MIRT016073)

    Block miRNA regulation of human, mouse, rat RHOU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOU (see all 26):
    hsa-miR-498 hsa-miR-3910 hsa-miR-140-5p hsa-miR-607 hsa-miR-562 hsa-miR-448 hsa-miR-938 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOU 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RHOU
    Predesigned siRNA for gene silencing in human, mouse, rat RHOU

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RHOU

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    GenScript: all cDNA clones in your preferred vector: RHOU (NM_021205)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOU

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RHOU_HUMAN, Q7L0Q8: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell
    junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    plasma membrane5
    cytosol4
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0002102podosome IEA--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    RHOU for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOU About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RHOU
        Rho GTPase cycle



    RHOU for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including RHOU: 
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RHOU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOU (Q7L0Q81, 2, 3 ENSP000003556524) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131532, 3, ENSP000002785684MINT-50674 MINT-7300795 MINT-50675 I2D: score=3 STRING: ENSP00000278568
    PLCG1P191742, 3, ENSP000002440074MINT-50686 MINT-50690 I2D: score=1 STRING: ENSP00000244007
    PTK2BQ142891, 3, ENSP000003328164EBI-1638043,EBI-298640 I2D: score=1 STRING: ENSP00000332816
    NCK2O436391, 2, 3, ENSP000002331544EBI-1638043,EBI-713635 MINT-7300813 MINT-7300841 MINT-7136617 MINT-7136730 MINT-7300769 I2D: score=2 STRING: ENSP00000233154
    GRB2P629932, 3, ENSP000003390074MINT-50683 MINT-50677 MINT-50684 I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007010cytoskeleton organization IMP--

    RHOU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOU

    4 HMDB Compounds for RHOU    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RHOU gene: 
    NM_021205.5  

    Unigene Cluster for RHOU:

    Ras homolog family member U
    Hs.647774  [show with all ESTs]
    Unigene Representative Sequence: NM_021205
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366691(uc021pkj.1 uc001htf.3) ENST00000473307 ENST00000493528

    miRNA
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    Block miRNA regulation of human, mouse, rat RHOU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOU (see all 26):
    hsa-miR-498 hsa-miR-3910 hsa-miR-140-5p hsa-miR-607 hsa-miR-562 hsa-miR-448 hsa-miR-938 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOU 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RHOU
    Clone
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RHOU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOU
      QuantiTect SYBR Green Assays in human, mouse, rat RHOU
      QuantiFast Probe-based Assays in human, mouse, rat RHOU

    Additional mRNA sequence: 

    AB051826.1 AB074878.1 AB209511.1 AF211836.1 AF251701.1 AF282258.1 AF378087.1 AK001478.1 
    AK289971.1 BC040076.1 NR_037962.1 

    10 DOTS entries:

    DT.448447  DT.91750861  DT.121336282  DT.100721117  DT.75103516  DT.121350137  DT.121430106  DT.100784280 
    DT.100784286  DT.121336270 

    Selected AceView cDNA sequences (see all 209):

    AI359768 AA719149 AA503364 BG565410 AA778115 Z39926 AI471090 AA923007 
    F01671 BX100860 AW169702 BF725546 AI342277 BE348647 AW243921 CB216082 
    CD364428 AA011659 AB051826 BE858142 NM_021205 AB074878 AI382139 AA700701 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTATAAA
    RHOU Expression
    About this image


    RHOU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Liver (Hepatobiliary System)
             Liver Bud
    RHOU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOU Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647774

    UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8
    Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small
    intestine, brain, skeletal muscle and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including RHOU: 
              WNT Signaling Pathway in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat RHOU
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RHOU gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhou1 , 5 ras homolog gene family, member U1, 5 86.12(n)1
    92.22(a)1
      8 (72.10 cM)5
    695811  NM_133955.41  NP_598716.11 
     1236539295 
    chicken
    (Gallus gallus)
    Aves RHOU1 ras homolog family member U 84.99(n)
    99.34(a)
      428589  XM_426146.4  XP_426146.4 
    lizard
    (Anolis carolinensis)
    Reptilia RHOU6
    ras homolog family member U
    78(a)
    1 ↔ 1
    1(221813440-221825816)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.46212 Xenopus laevis transcribed sequence with weak similarity more 76.99(n)    48053146 
    zebrafish
    (Danio rerio)
    Actinopterygii rhoua1 ras homolog gene family, member Ua 74.88(n)
    82.13(a)
      492802  NM_001007443.1  NP_001007444.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG341046
    --
    18(a)
    1 → many
    X(9980566-10042911)
    worm
    (Caenorhabditis elegans)
    Secernentea chw-16
    Protein CHW-1 (chw-1) mRNA, complete cds
    48(a)
    1 → many
    V(10462282-10464660) WBGene00009059


    ENSEMBL Gene Tree for RHOU (if available)
    TreeFam Gene Tree for RHOU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOU gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOG2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    Selected SIMAP similar genes for RHOU using alignment to 1 protein entry:     RHOU_HUMAN(see all similar genes):
    CDC42    RHOA    RHOC    RHOQ    RAC2    ARHG
    RHOB    RHOG    RHOJ    RAC3    RAC1    RHOV
    RHOD    ARHH    RHOH    ARHE    RND3    RND2

    RHOU for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOU (see all 1722)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850137381,2
    --228788756(+) GTTCAA/GTAAGA 1 -- int10--------
    rs1905613331,2
    --228788855(+) AAACAA/CAGTCT 1 -- int10--------
    rs1166357291,2
    C,F--228788884(+) GCTACC/GTAGCC 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1423443571,2
    C--228788922(+) GACAAA/GGTCTC 1 -- int10--------
    rs1929791071,2
    --228788959(+) GGCACA/GATCGT 1 -- int10--------
    rs751003831,2
    C,F--228789016(+) TCATGC/TCTCAG 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1140326581,2
    F--228789087(+) TTTTGA/GCGGAG 1 -- int11Minor allele frequency- G:0.05WA 118
    rs45500171,2
    C,F,H--228789231(+) ccagcC/Taattt 1 -- int15Minor allele frequency- T:0.50NA WA CSA 10
    rs1852686961,2
    --228789276(+) GGTCTG/TGCTGG 1 -- int10--------
    rs1895778271,2
    --228789324(+) GCCTCC/GCAAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for RHOU (228780394 - 228882416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RHOU (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678504CNV Deletion23128226
    esv1454255CNV Deletion17803354
    esv2724395CNV Deletion23290073
    nsv820567CNV Deletion20802225
    esv2724406CNV Deletion23290073
    nsv509635CNV Insertion20534489
    esv6055CNV Loss19470904
    nsv827075CNV Loss20364138
    nsv511738CNV Loss21212237
    dgv106n67CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606366    OMIM disorders: --

    8 diseases for RHOU:    
    About MalaCards
    denture stomatitis    stomatitis    dental caries    basal cell carcinoma
    endometriosis    parkinson's disease    melanoma    cerebritis

    1 disease from the University of Copenhagen DISEASES database for RHOU:
    Denture stomatitis

    RHOU for disorders           About GeneDecksing

    Genetic Association Database (GAD): RHOU
    Human Genome Epidemiology (HuGE) Navigator: RHOU (1 document)

    Export disorders for RHOU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for RHOU gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with RHOU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. (PubMed id 11459829)1, 2, 3 Tao W.... Levine A.J. (Genes Dev. 2001)
    2. Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. (PubMed id 11894124)1, 2, 9 Kirikoshi H. and Katoh M. (Int. J. Oncol. 2002)
    3. The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. (PubMed id 18086875)1, 2, 9 Ruusala A. and Aspenstrom P. (Mol. Cell. Biol. 2008)
    4. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PubMed id 21565175)1, 2 Naji L.... Aspenstrom P. (Biochem. Biophys. Res. Commun. 2011)
    5. Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population. (PubMed id 20844546)1, 4 Adachi S....Tanaka K. (J. Hum. Genet. 2010)
    6. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PubMed id 18849993)1, 4 Stacey S.N....Stefansson K. (Nat. Genet. 2008)
    7. Scan of human genome reveals no new loci under ancient balancing selection. (PubMed id 16751668)1, 2 Bubb K.L.... Olson M.V. (Genetics 2006)
    8. Novel human, mouse and Xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum. (PubMed id 14731133)1, 2 Daigo Y.... Fujino M.A. (J. Gastroenterol. Hepatol. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins. (PubMed id 23183748)1 Risse S.L....Ahmadian M.R. (Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 58480 HGNC: 17794 AceView: RHOU Ensembl:ENSG00000116574 euGenes: HUgn58480
    ECgene: RHOU H-InvDB: RHOU

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RHOU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RHOU gene:
    Search GeneIP for patents involving RHOU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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