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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOU Gene

protein-coding   GIFtS: 57
GCID: GC01P228785

Ras Homolog Family Member U

(Previous names: ras homolog gene family, member U)
(Previous symbol: ARHU)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ras Homolog Family Member U1 2     CDC42L12 3
ARHU1 2 3     CDC42-Like GTPase 12 3
Ryu GTPase1 2 3     CDC42-Like GTPase1
WRCH12 3 5     Wnt-1 Responsive Cdc42 Homolog1
Ras Homolog Gene Family, Member U1 2     DJ646B12.22
2310026M05Rik1 2     fJ646B12.22
GTP-Binding Protein Like 11 2     hG28K2
GTP-Binding Protein SB1281 2     Rho-Related GTP-Binding Protein RhoU2
Ras-Like Gene Family Member U1 2     G28K3
Rho GTPase-Like Protein ARHU2 3     WRCH-13
Wnt-1 Responsive Cdc42 Homolog 12 3     GTP-Binding Protein-Like 13

External Ids:    HGNC: 177941   Entrez Gene: 584802   Ensembl: ENSG000001165747   OMIM: 6063665   UniProtKB: Q7L0Q83   
ORGUL members:         
NONCODE14:n326192 n410702 n405666      

Export aliases for RHOU gene to outside databases

Previous GC identifers: GC01P225833 GC01P225177 GC01P226937 GC01P228870 GC01P199361


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOU Gene:
This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce
filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the
regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant
of this gene results from naturally occurring read-through transcription between this locus and the neighboring
DUSP5P (dual specificity phosphatase 5 pseudogene) locus.(provided by RefSeq, Mar 2011)

GeneCards Summary for RHOU Gene: 
RHOU (ras homolog family member U) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RHOU include denture stomatitis, and stomatitis, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOH.

UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8
Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration.
Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic
guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of
cell morphology and cytoskeletal organization. Required in the control of cell shape




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOU gene promoter:
         Nkx2-5   MIF-1   Nkx5-1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOU promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOU

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.11-q42.3   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.11-q42.3

RHOU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOU gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P228785:  view genomic region     (about GC identifiers)

Start:
228,780,394 bp from pter      End:
228,882,416 bp from pter
Size:
102,023 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RHOU

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoU  
Size: 258 amino acids; 28218 Da
Cofactor: Magnesium
Subunit: Interacts with PAK3. Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation,
interacts with ARHGAP31. Interacts with PTK2B/PYK2
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell
junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells
1 PDB 3D structure from and Proteopedia for RHOU:
2Q3H (3D)    
Secondary accessions: B1AKN1 Q59FE9 Q8TDQ2
Alternative splicing: 2 isoforms:  Q7L0Q8-1   Q7L0Q8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHOU: NX_Q7L0Q8

Explore proteomics data for RHOU at MOPED 

Post-translational modifications:

  • UniProtKB: Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L0Q8

  • RHOU Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOU Protein Expression
    REFSEQ proteins: NP_067028.1  
    ENSEMBL proteins: 
     ENSP00000355652  
    Reactome Protein details: Q7L0Q8
    Human Recombinant Protein Products for RHOU: 
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    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0002102podosome IEA--
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    RHOU for ontologies           About GeneDecksing



    RHOU Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q7L0Q8

    ProtoNet protein and cluster: Q7L0Q8

    UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RHOU for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RHOU_HUMAN, Q7L0Q8
    Function: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration.
    Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic
    guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of
    cell morphology and cytoskeletal organization. Required in the control of cell shape

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI14521508
    GO:0005525GTP binding IEA--
    GO:0046872metal ion binding IEA--
         
    RHOU for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RHOU:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOU 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOU

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOU 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOU 

    miRNA
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    hsa-miR-498 hsa-miR-3910 hsa-miR-140-5p hsa-miR-607 hsa-miR-562 hsa-miR-448 hsa-miR-938 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOU 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHOU About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for RHOU
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    RHOU for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for RHOU (Q7L0Q81, 2, 3 ENSP000003556524) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131532, 3, ENSP000002785684MINT-50674 MINT-7300795 MINT-50675 I2D: score=3 STRING: ENSP00000278568
    PLCG1P191742, 3, ENSP000002440074MINT-50686 MINT-50690 I2D: score=1 STRING: ENSP00000244007
    PTK2BQ142891, 3, ENSP000003328164EBI-1638043,EBI-298640 I2D: score=1 STRING: ENSP00000332816
    NCK2O436391, 2, 3, ENSP000002331544EBI-1638043,EBI-713635 MINT-7300813 MINT-7300841 MINT-7136617 MINT-7136730 MINT-7300769 I2D: score=2 STRING: ENSP00000233154
    GRB2P629932, 3, ENSP000003390074MINT-50683 MINT-50677 MINT-50684 I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----
    GO:0007010cytoskeleton organization IMP--

    RHOU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOU

    4 HMDB Compounds for RHOU    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about RHOU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHOU gene: 
    NM_021205.5  

    Unigene Cluster for RHOU:

    Ras homolog family member U
    Hs.647774  [show with all ESTs]
    Unigene Representative Sequence: NM_021205
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366691(uc021pkj.1 uc001htf.3) ENST00000473307 ENST00000493528

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOU (see all 26):
    hsa-miR-498 hsa-miR-3910 hsa-miR-140-5p hsa-miR-607 hsa-miR-562 hsa-miR-448 hsa-miR-938 hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOU 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB051826.1 AB074878.1 AB209511.1 AF211836.1 AF251701.1 AF282258.1 AF378087.1 AK001478.1 
    AK289971.1 BC040076.1 NR_037962.1 

    10 DOTS entries:

    DT.448447  DT.91750861  DT.121336282  DT.100721117  DT.75103516  DT.121350137  DT.121430106  DT.100784280 
    DT.100784286  DT.121336270 

    24/209 AceView cDNA sequences (see all 209):

    CR616242 AI057486 F03335 AI124646 N58316 AI094830 AA011659 AB051826 
    BE858142 NM_021205 AB074878 AI382139 AA700701 BU732648 AI687503 BC040076 
    AK001478 AA602716 CN478603 BM717858 N77681 AI082642 AU120225 BP380012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOU expression in normal human tissues (normalized intensities)      RHOU embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTATAAA
    RHOU Expression
    About this image


    RHOU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Thalamus
             Substantia Nigra   
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Liver Bud
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Chorion (Extraembryonic Tissues)
             Human Chorionic Mesenchymal Stromal Cells (HCMSC)   

    See RHOU Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOU

    SOURCE GeneReport for Unigene cluster: Hs.647774

    UniProtKB/Swiss-Prot: RHOU_HUMAN, Q7L0Q8
    Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small
    intestine, brain, skeletal muscle and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including RHOU: 
              WNT Signaling Pathway in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RHOU gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhou1 , 5 ras homolog gene family, member U1, 5 86.33(n)1
    92.58(a)1
      8 (72.10 cM)5
    695811  NM_133955.41  NP_598716.11 
     1236539295 
    chicken
    (Gallus gallus)
    Aves RHOU1 ras homolog gene family, member U 84.71(n)
    98.82(a)
      428589  XM_426146.3  XP_426146.3 
    lizard
    (Anolis carolinensis)
    Reptilia RHOU6
    Uncharacterized protein
    76(a)
    1 ↔ 1
    1(221813440-221825816)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.46212 Xenopus laevis transcribed sequence with weak similarity more 76.99(n)    48053146 
    zebrafish
    (Danio rerio)
    Actinopterygii rhoua1 ras homolog gene family, member Ua 70.27(n)
    74.8(a)
      492802  NM_001007443.1  NP_001007444.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG341046
    --
    17(a)
    1 → many
    X(9980566-10042911)
    worm
    (Caenorhabditis elegans)
    Secernentea chw-16
    crp-16
    Protein CRP-1
    45(a)
    37(a)
    many ↔ many
    many ↔ many
    V(10462282-10464660)
    V(10478590-10480965)


    ENSEMBL Gene Tree for RHOU (if available)
    TreeFam Gene Tree for RHOU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOU gene
    RHOH2  RHOQ2  RHOBTB12  RHOV2  RHOG2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    18/22 SIMAP similar genes for RHOU using alignment to 1 protein entry:     RHOU_HUMAN(see all similar genes):
    CDC42    RHOA    RHOC    RHOQ    RAC2    ARHG
    RHOB    RHOG    RHOJ    RAC3    RAC1    RHOV
    RHOD    ARHH    RHOH    ARHE    RND3    RND2

    RHOU for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1722 SNPs in RHOU are shown (see all 1722)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850137381,2
    --228788756(+) GTTCAA/GTAAGA 1 -- int10--------
    rs1905613331,2
    --228788855(+) AAACAA/CAGTCT 1 -- int10--------
    rs1166357291,2
    C,F--228788884(+) GCTACC/GTAGCC 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1423443571,2
    C--228788922(+) GACAAA/GGTCTC 1 -- int10--------
    rs1929791071,2
    --228788959(+) GGCACA/GATCGT 1 -- int10--------
    rs751003831,2
    C,F--228789016(+) TCATGC/TCTCAG 1 -- int11Minor allele frequency- T:0.02EA 120
    rs1140326581,2
    F--228789087(+) TTTTGA/GCGGAG 1 -- int11Minor allele frequency- G:0.05WA 118
    rs45500171,2
    C,F,H--228789231(+) ccagcC/Taattt 1 -- int15Minor allele frequency- T:0.50NA WA CSA 10
    rs1852686961,2
    --228789276(+) GGTCTG/TGCTGG 1 -- int10--------
    rs1895778271,2
    --228789324(+) GCCTCC/GCAAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for RHOU (228780394 - 228882416 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for RHOU (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678504CNV Deletion23128226
    esv1454255CNV Deletion17803354
    esv2724395CNV Deletion23290073
    nsv820567CNV Deletion20802225
    esv2724406CNV Deletion23290073
    nsv509635CNV Insertion20534489
    esv6055CNV Loss19470904
    nsv827075CNV Loss20364138
    nsv511738CNV Loss21212237
    dgv106n67CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606366    OMIM disorders: --

    5 diseases for RHOU:    About MalaCards
    denture stomatitis    stomatitis    basal cell carcinoma    endometriosis
    melanoma

    1 disease from the University of Copenhagen DISEASES database for RHOU:
    Denture stomatitis

    RHOU for disorders           About GeneDecksing

    Genetic Association Database (GAD): RHOU
    Human Genome Epidemiology (HuGE) Navigator: RHOU (1 document)

    Export disorders for RHOU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOU gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with RHOU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. (PubMed id 11459829)1, 2, 3 Tao W.... Levine A.J. (2001)
    2. Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. (PubMed id 11894124)1, 2, 9 Kirikoshi H. and Katoh M. (2002)
    3. The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. (PubMed id 18086875)1, 2, 9 Ruusala A. and Aspenstrom P. (2008)
    4. ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion. (PubMed id 21565175)1, 2 Naji L.... Aspenstrom P. (2011)
    5. Meta-analysis of genome-wide association scans for ge netic susceptibility to endometriosis in Japanese population. (PubMed id 20844546)1, 4 Adachi S....Tanaka K. (2010)
    6. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PubMed id 18849993)1, 4 Stacey S.N....Stefansson K. (2008)
    7. Scan of human genome reveals no new loci under ancient balancing selection. (PubMed id 16751668)1, 2 Bubb K.L.... Olson M.V. (2006)
    8. Novel human, mouse and xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/WV mouse jejunum. (PubMed id 14731133)1, 2 Daigo Y.... Fujino M.A. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. SH3-mediated targeting of Wrch1/RhoU by multiple adapt or proteins. (PubMed id 23183748)1 Risse S.L....Ahmadian M.R. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58480 HGNC: 17794 AceView: RHOU Ensembl:ENSG00000116574 euGenes: HUgn58480
    ECgene: RHOU H-InvDB: RHOU

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHOU gene:
    Search GeneIP for patents involving RHOU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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