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Aliases for RHOU Gene

Aliases for RHOU Gene

  • Ras Homolog Family Member U 2 3 5
  • Ryu GTPase 2 3 4
  • Ras Homolog Gene Family, Member U 2 3
  • Wnt-1 Responsive Cdc42 Homolog 1 3 4
  • Ras-Like Gene Family Member U 2 3
  • Rho GTPase-Like Protein ARHU 3 4
  • GTP-Binding Protein Like 1 2 3
  • GTP-Binding Protein SB128 2 3
  • CDC42-Like GTPase 1 3 4
  • 2310026M05Rik 2 3
  • CDC42L1 3 4
  • WRCH1 3 4
  • ARHU 3 4
  • G28K 3 4
  • Wnt-1 Responsive Cdc42 Homolog 2
  • GTP-Binding Protein-Like 1 4
  • CDC42-Like GTPase 2
  • WRCH-1 4
  • HG28K 3

External Ids for RHOU Gene

Previous HGNC Symbols for RHOU Gene

  • ARHU

Previous GeneCards Identifiers for RHOU Gene

  • GC01P225833
  • GC01P225177
  • GC01P226937
  • GC01P228870
  • GC01P199361
  • GC01P228785

Summaries for RHOU Gene

Entrez Gene Summary for RHOU Gene

  • This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]

GeneCards Summary for RHOU Gene

RHOU (Ras Homolog Family Member U) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOU Gene

  • Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOU Gene

Genomics for RHOU Gene

Regulatory Elements for RHOU Gene

Genomic Location for RHOU Gene

Chromosome:
1
Start:
228,644,647 bp from pter
End:
228,746,669 bp from pter
Size:
102,023 bases
Orientation:
Plus strand

Genomic View for RHOU Gene

Genes around RHOU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOU Gene

Proteins for RHOU Gene

  • Protein details for RHOU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L0Q8-RHOU_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoU
    Protein Accession:
    Q7L0Q8
    Secondary Accessions:
    • B1AKN1
    • Q59FE9
    • Q8TDQ2

    Protein attributes for RHOU Gene

    Size:
    258 amino acids
    Molecular mass:
    28218 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PAK3. Interacts with ARHGAP30 in a GTP-independent manner. In its GTP-loaded conformation, interacts with ARHGAP31. Interacts with PTK2B/PYK2.

    Three dimensional structures from OCA and Proteopedia for RHOU Gene

    Alternative splice isoforms for RHOU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOU Gene

Proteomics data for RHOU Gene at MOPED

Post-translational modifications for RHOU Gene

  • Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOU Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RHOU Gene

Domains & Families for RHOU Gene

Gene Families for RHOU Gene

Protein Domains for RHOU Gene

Suggested Antigen Peptide Sequences for RHOU Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L0Q8

UniProtKB/Swiss-Prot:

RHOU_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOU: view

Function for RHOU Gene

Molecular function for RHOU Gene

UniProtKB/Swiss-Prot Function:
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
genes like me logo Genes that share phenotypes with RHOU: view

Animal Model Products

miRNA for RHOU Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOU Gene

Localization for RHOU Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOU Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells. {ECO:0000269 PubMed:16046391, ECO:0000269 PubMed:16472646, ECO:0000269 PubMed:17620058}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOU Gene COMPARTMENTS Subcellular localization image for RHOU gene
Compartment Confidence
cytosol 5
cytoskeleton 4
plasma membrane 4
golgi apparatus 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RHOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RHOU: view

Pathways & Interactions for RHOU Gene

genes like me logo Genes that share pathways with RHOU: view

Pathways by source for RHOU Gene

Gene Ontology (GO) - Biological Process for RHOU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006913 nucleocytoplasmic transport IEA --
GO:0008152 metabolic process IEA --
GO:0015031 protein transport IEA --
GO:0016601 Rac protein signal transduction IEA --
genes like me logo Genes that share ontologies with RHOU: view

No data available for SIGNOR curated interactions for RHOU Gene

Drugs & Compounds for RHOU Gene

(4) Drugs for RHOU Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
Magnesium Nutra 0
genes like me logo Genes that share compounds with RHOU: view

Transcripts for RHOU Gene

mRNA/cDNA for RHOU Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(209) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RHOU Gene

Ras homolog family member U:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOU Gene

No ASD Table

Relevant External Links for RHOU Gene

GeneLoc Exon Structure for
RHOU
ECgene alternative splicing isoforms for
RHOU

Expression for RHOU Gene

mRNA expression in normal human tissues for RHOU Gene

Protein differential expression in normal tissues from HIPED for RHOU Gene

This gene is overexpressed in Tlymphocyte (22.8), Monocytes (17.0), Pancreas (16.3), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RHOU Gene



SOURCE GeneReport for Unigene cluster for RHOU Gene Hs.647774

mRNA Expression by UniProt/SwissProt for RHOU Gene

Q7L0Q8-RHOU_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.
genes like me logo Genes that share expression patterns with RHOU: view

Protein tissue co-expression partners for RHOU Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RHOU Gene

Orthologs for RHOU Gene

This gene was present in the common ancestor of animals.

Orthologs for RHOU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOU 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOU 36
  • 95 (a)
OneToOne
RHOU 35
  • 87.58 (n)
  • 94.12 (a)
dog
(Canis familiaris)
Mammalia RHOU 35
  • 92.64 (n)
  • 98.06 (a)
RHOU 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhou 36
  • 90 (a)
OneToOne
Rhou 16
Rhou 35
  • 86.12 (n)
  • 92.22 (a)
oppossum
(Monodelphis domestica)
Mammalia RHOU 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOU 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOU 36
  • 96 (a)
OneToOne
RHOU 35
  • 84.99 (n)
  • 99.34 (a)
lizard
(Anolis carolinensis)
Reptilia RHOU 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4621 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rhou 35
  • 66.99 (n)
  • 69.08 (a)
Str.181 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1184 35
zebrafish
(Danio rerio)
Actinopterygii RHOU (1 of 3) 36
  • 58 (a)
OneToMany
rhoua 36
  • 74 (a)
OneToMany
rhoub 36
  • 65 (a)
OneToMany
rhoua 35
  • 74.88 (n)
  • 82.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34104 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea chw-1 36
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9013 36
  • 55 (a)
OneToMany
Species with no ortholog for RHOU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOU Gene

ENSEMBL:
Gene Tree for RHOU (if available)
TreeFam:
Gene Tree for RHOU (if available)

Paralogs for RHOU Gene

Paralogs for RHOU Gene

(22) SIMAP similar genes for RHOU Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RHOU: view

Variants for RHOU Gene

Sequence variations from dbSNP and Humsavar for RHOU Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs13895 -- 228,746,396(-) GTATG(A/C)TGTAT nc-transcript-variant, utr-variant-3-prime
rs765070 -- 228,670,108(-) CTGCC(A/G)TTAAC intron-variant
rs1062060 -- 228,744,274(+) AAAAC(C/T)TCAAA nc-transcript-variant, utr-variant-3-prime
rs1045497 -- 228,745,454(+) TATAG(A/G)AAAAG nc-transcript-variant, utr-variant-3-prime
rs1543419 -- 228,672,404(+) ATGGT(C/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOU Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
esv24714 CNV Gain+Loss 19812545
nsv827075 CNV Loss 20364138
nsv509635 CNV Insertion 20534489
nsv511020 CNV Complex 20534489
nsv511124 CNV Loss 21212237
dgv106n67 CNV Loss 20364138
nsv820567 CNV Deletion 20802225
nsv511738 CNV Loss 21212237
esv6055 CNV Loss 19470904
esv2724395 CNV Deletion 23290073
esv1454255 CNV Deletion 17803354
esv2724406 CNV Deletion 23290073
esv2678504 CNV Deletion 23128226

Variation tolerance for RHOU Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOU Gene

HapMap Linkage Disequilibrium report
RHOU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOU Gene

Disorders for RHOU Gene

Relevant External Links for RHOU

Genetic Association Database (GAD)
RHOU
Human Genome Epidemiology (HuGE) Navigator
RHOU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOU

No disorders were found for RHOU Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOU Gene

Publications for RHOU Gene

  1. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. (PMID: 11459829) Tao W. … Levine A.J. (Genes Dev. 2001) 2 3 4 67
  2. The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. (PMID: 18086875) Ruusala A. … Aspenstrom P. (Mol. Cell. Biol. 2008) 3 23
  3. Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells. (PMID: 11894124) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2002) 3 23
  4. Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. (PMID: 24403052) Stacey S.N. … Stefansson K. (Hum. Mol. Genet. 2014) 3
  5. MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1/2 and Wnt/I^-catenin signal pathways. (PMID: 23811937) Ye X. … Yang D. (Cell. Mol. Life Sci. 2013) 3

Products for RHOU Gene

Sources for RHOU Gene

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