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Aliases for RHOT2 Gene

Aliases for RHOT2 Gene

  • Ras Homolog Family Member T2 2 3
  • ARHT2 3 4 6
  • Ras Homolog Gene Family, Member T2 2 3
  • Mitochondrial Rho (MIRO) GTPase 2 2 3
  • C16orf39 3 4
  • MIRO-2 3 4
  • MIRO2 3 6
  • Chromosome 16 Open Reading Frame 39 2
  • Ras Homolog Gene Family Member T2 4
  • Mitochondrial Rho GTPase 2 3
  • EC 3.6.5.- 4
  • EC 3.6.5 63
  • HMiro-2 4
  • RASL 3

External Ids for RHOT2 Gene

Previous HGNC Symbols for RHOT2 Gene

  • C16orf39
  • ARHT2

Previous GeneCards Identifiers for RHOT2 Gene

  • GC16P000660
  • GC16P000661
  • GC16P000719
  • GC16P000649
  • GC16P000720
  • GC16P000722
  • GC16P000723
  • GC16P000727
  • GC16P000792
  • GC16P000826
  • GC16P000847

Summaries for RHOT2 Gene

Entrez Gene Summary for RHOT2 Gene

  • This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]

GeneCards Summary for RHOT2 Gene

RHOT2 (Ras Homolog Family Member T2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT1.

UniProtKB/Swiss-Prot for RHOT2 Gene

  • Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).

Gene Wiki entry for RHOT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOT2 Gene

Genomics for RHOT2 Gene

Regulatory Elements for RHOT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RHOT2 Gene

Start:
668,083 bp from pter
End:
674,174 bp from pter
Size:
6,092 bases
Orientation:
Plus strand

Genomic View for RHOT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOT2 Gene

Proteins for RHOT2 Gene

  • Protein details for RHOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXI1-MIRO2_HUMAN
    Recommended name:
    Mitochondrial Rho GTPase 2
    Protein Accession:
    Q8IXI1
    Secondary Accessions:
    • A2IDC2
    • Q8NF53
    • Q96C13
    • Q96S17
    • Q9BT60
    • Q9H7M8

    Protein attributes for RHOT2 Gene

    Size:
    618 amino acids
    Molecular mass:
    68118 Da
    Quaternary structure:
    • Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules.
    SequenceCaution:
    • Sequence=AAK61240.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB15740.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03407.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RHOT2 Gene

Proteomics data for RHOT2 Gene at MOPED

Post-translational modifications for RHOT2 Gene

  • Ubiquitination at Lys119, Lys179, Lys230, Lys420, and Lys429
  • Modification sites at PhosphoSitePlus

Other Protein References for RHOT2 Gene

Domains for RHOT2 Gene

Gene Families for RHOT2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Suggested Antigen Peptide Sequences for RHOT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXI1

UniProtKB/Swiss-Prot:

MIRO2_HUMAN :
  • Q8IXI1
Domain:
  • Contains 2 EF-hand domains.
  • Contains 2 Miro domains.
Family:
  • Belongs to the mitochondrial Rho GTPase family.
genes like me logo Genes that share domains with RHOT2: view

Function for RHOT2 Gene

Molecular function for RHOT2 Gene

UniProtKB/Swiss-Prot Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).

Enzyme Numbers (IUBMB) for RHOT2 Gene

Gene Ontology (GO) - Molecular Function for RHOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16630562
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOT2: view

Phenotypes for RHOT2 Gene

genes like me logo Genes that share phenotypes with RHOT2: view

Animal Models for RHOT2 Gene

MGI Knock Outs for RHOT2:

Animal Model Products

CRISPR Products

miRNA for RHOT2 Gene

miRTarBase miRNAs that target RHOT2

No data available for Transcription Factor Targeting and HOMER Transcription for RHOT2 Gene

Localization for RHOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOT2 Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOT2 Gene COMPARTMENTS Subcellular localization image for RHOT2 gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 4
peroxisome 2
endoplasmic reticulum 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RHOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005741 mitochondrial outer membrane --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RHOT2: view

Pathways for RHOT2 Gene

genes like me logo Genes that share pathways with RHOT2: view

Pathways by source for RHOT2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RHOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008152 metabolic process IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RHOT2: view

Transcripts for RHOT2 Gene

Unigene Clusters for RHOT2 Gene

Ras homolog family member T2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RHOT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOT2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - -
SP10: - - - - -
SP11: - - - - - -
SP12: - - - - -
SP13: - - - - - -
SP14: - - - - - - - - - - - - - - - - -
SP15: - -
SP16: - - -
SP17: - -
SP18: -
SP19: - - - - - -
SP20: - - - - -
SP21: - -
SP22: - - -
SP23: - -
SP24:
SP25:
SP26: - -
SP27: - - -
SP28:
SP29:
SP30: -
SP31:
SP32: - - -
SP33:

ExUns: 12b · 12c · 12d ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c · 24d · 24e
SP1: - - -
SP2: - - -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - - - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: -
SP24:
SP25:
SP26:
SP27:
SP28: -
SP29: -
SP30:
SP31:
SP32:
SP33: -

Relevant External Links for RHOT2 Gene

GeneLoc Exon Structure for
RHOT2
ECgene alternative splicing isoforms for
RHOT2

Expression for RHOT2 Gene

mRNA expression in normal human tissues for RHOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOT2 Gene

SOURCE GeneReport for Unigene cluster for RHOT2 Gene Hs.513242

mRNA Expression by UniProt/SwissProt for RHOT2 Gene

Q8IXI1-MIRO2_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with RHOT2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RHOT2 Gene

Orthologs for RHOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOT2 35
  • 98.86 (n)
  • 98.84 (a)
RHOT2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOT2 35
  • 85.09 (n)
  • 85.9 (a)
RHOT2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOT2 35
  • 83.83 (n)
  • 85.64 (a)
RHOT2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm20683 36
  • 80 (a)
OneToMany
Rhot2 35
  • 81.82 (n)
  • 85.28 (a)
Rhot2 16
Rhot2 36
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RHOT2 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOT2 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhot2 35
  • 81.61 (n)
  • 84.79 (a)
chicken
(Gallus gallus)
Aves RHOT2 35
  • 74.69 (n)
  • 73.98 (a)
RHOT2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOT2 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15769 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rhot2 35
  • 69.66 (n)
  • 71.29 (a)
Str.15678 35
zebrafish
(Danio rerio)
Actinopterygii rhot2 35
  • 66.4 (n)
  • 65.96 (a)
rhot2 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Miro 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea miro-1 36
  • 43 (a)
ManyToMany
miro-2 36
  • 40 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR402W 35
  • 45.1 (n)
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEM1 35
  • 43.05 (n)
  • 36.1 (a)
GEM1 36
  • 29 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03465g 35
  • 41.88 (n)
  • 34.9 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MIRO1 35
  • 45.83 (n)
  • 39.61 (a)
rice
(Oryza sativa)
Liliopsida Os.15115 35
Os03g0810600 35
  • 49.2 (n)
  • 42.1 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03966 35
  • 49.18 (n)
  • 39.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC320.04c 35
  • 43.46 (n)
  • 37.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for RHOT2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOT2 Gene

ENSEMBL:
Gene Tree for RHOT2 (if available)
TreeFam:
Gene Tree for RHOT2 (if available)

Paralogs for RHOT2 Gene

Paralogs for RHOT2 Gene

Selected SIMAP similar genes for RHOT2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RHOT2: view

Variants for RHOT2 Gene

Sequence variations from dbSNP and Humsavar for RHOT2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1045709 -- 670,965(+) CGTGG(C/T)GGGCG reference, missense
rs1045716 -- 673,647(+) GTGTG(C/G)CTCGC utr-variant-3-prime
rs1128550 -- 672,548(+) AATGG(A/G)CAGGA reference, synonymous-codon
rs1139897 - 670,986(+) GGACC(A/G)GCTGA missense, reference
rs2071830 -- 668,862(-) GCTCC(C/T)AGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOT2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
dgv334n27 CNV Loss 19166990
nsv904760 CNV Loss 21882294
dgv2487n71 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
nsv904785 CNV Gain+Loss 21882294
dgv2490n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
nsv457310 CNV Loss 19166990
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
nsv904799 CNV Loss 21882294
nsv482180 CNV Gain 20164927
nsv827480 CNV Gain 20364138
nsv827481 CNV Gain 20364138
dgv2493n71 CNV Loss 21882294

Relevant External Links for RHOT2 Gene

HapMap Linkage Disequilibrium report
RHOT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOT2 Gene

Disorders for RHOT2 Gene

Relevant External Links for RHOT2

Genetic Association Database (GAD)
RHOT2
Human Genome Epidemiology (HuGE) Navigator
RHOT2
genes like me logo Genes that share disorders with RHOT2: view

No data available for UniProtKB/Swiss-Prot for RHOT2 Gene

Publications for RHOT2 Gene

  1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PMID: 12482879) Fransson A. … Aspenstroem P. (J. Biol. Chem. 2003) 2 3 4
  2. Rho GTPases have diverse effects on the organization of the actin filament system. (PMID: 14521508) Aspenstroem P. … Saras J. (Biochem. J. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase. (PMID: 15218247) Shan Y. … Yu L. (Cytogenet. Genome Res. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RHOT2 Gene

Sources for RHOT2 Gene

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