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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RHOT2 Gene

protein-coding GIFtS: 53
GCID: GC16P000792

ras homolog family member T2

(Previous names: chromosome 16 open reading frame 39, ras homolog gene family,...)
(Previous symbols: C16orf39, ARHT2)

Explore 1 disease affiliated with
RHOT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ras Homolog Family Member T2¹ ²		RASL²
ARHT2¹ ² ³		Mitochondrial Rho (MIRO) GTPase 2²
C16orf39¹ ² ³		Mitochondrial Rho GTPase 2²
MIRO-2¹ ² ³		EC 3.6.5.-³
Ras Homolog Gene Family, Member T2¹ ²		HMiro-2¹
Chromosome 16 Open Reading Frame 39¹		Ras Homolog Gene Family Member T2³
MIRO2²		EC 3.6.5⁸

External Ids:	HGNC: 21169¹	Entrez Gene: 89941²	Ensembl: ENSG00000140983⁷	OMIM: 613889⁵	UniProtKB: Q8IXI1³

Export aliases for RHOT2 gene to outside databases

Previous GC identifers: GC16P000660 GC16P000661 GC16P000719 GC16P000649 GC16P000720 GC16P000722 GC16P000723 GC16P000727

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RHOT2:

This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial

membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: MIRO2_HUMAN, Q8IXI1

Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde

transport of mitochondria and their subcellular distribution (By similarity)

Gene Wiki entry for RHOT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RHOT2 gene promoter:
CREB C/EBPbeta Sp1 p53 deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHOT2 promoter sequence

Search SABiosciences Chromatin IP Primers for RHOT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

RHOT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOT2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P000792: view genomic region (about GC identifiers)

Start:	718,086 bp from pter	End:	724,174 bp from pter
Size:	6,089 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MIRO2_HUMAN, Q8IXI1 (See protein sequence)

Recommended Name: Mitochondrial Rho GTPase 2

Size: 618 amino acids; 68118 Da

Subunit: Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria

and the trafficking apparatus of the microtubules (By similarity)

Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP

and RHOT2 at the mitochondria

Sequence caution: Sequence=AAK61240.1; Type=Erroneous gene model prediction; Sequence=BAB15740.1; Type=Erroneous

initiation; Sequence=BAC03407.1; Type=Erroneous initiation;

Secondary accessions: A2IDC2 Q8NF53 Q96C13 Q96S17 Q9BT60 Q9H7M8

Alternative splicing: 2 isoforms: Q8IXI1-1 Q8IXI1-2

Explore the universe of human proteins at neXtProt for RHOT2: NX_Q8IXI1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IXI1

4/9 DME Specific Peptides for RHOT2 (Q8IXI1) (see all 9)

GRHETTW

FQKSCFG

EEFPEEVP

PTHIVDYS

RHOT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_620124.1

ENSEMBL proteins:

ENSP00000321971 ENSP00000454307 ENSP00000459564 ENSP00000455138 ENSP00000458136

ENSP00000454486 ENSP00000457852 ENSP00000456855 ENSP00000457437

Reactome Protein details: Q8IXI1
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RHOT2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005743	mitochondrial inner membrane	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0031307	integral to mitochondrial outer membrane	IDA	19528298

RHOT2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RHOT2 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR011992 EF-hand-like_dom

IPR013566 EF_hand_assoc_1

IPR002048 EF_hand_Ca-bd

IPR013684 MIRO-like

IPR001806 Small_GTPase

Graphical View of Domain Structure for InterPro Entry Q8IXI1

ProtoNet protein and cluster: Q8IXI1

4 Blocks protein families:

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

IPB013567 EF hand associated

IPB013684 Miro-like

UniProtKB/Swiss-Prot: MIRO2_HUMAN, Q8IXI1

Similarity: Belongs to the mitochondrial Rho GTPase family

Similarity: Contains 2 EF-hand domains

Similarity: Contains 2 Miro domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MIRO2_HUMAN, Q8IXI1

Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde

transport of mitochondria and their subcellular distribution (By similarity)

Enzyme Numbers (IUBMB): EC 3.6.5² EC 3.6.5.-¹

miRNA Products:		OriGene 3'-UTR Clone: RHOT2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOT2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOT2:
		hsa-miR-4324 hsa-miR-125a-5p hsa-miR-125b hsa-miR-4251 hsa-miR-580 hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: RHOT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOT2 (see all 7) OriGene shRNA RFP: RHOT2 OriGene siRNA: RHOT2
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Gene Editing
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RHOT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RHOT2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOT2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	19528298
GO:0005525	GTP binding	IEA	--

RHOT2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for RHOT2

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

RHOT2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RHOT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/19 Interacting proteins for RHOT2 (Q8IXI1^{2, 3} ENSP00000321971⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZFYVE9	O95405²^,³	MINT-62052 I2D: score=3
RYK	P34925³, ENSP00000296084⁴	I2D: score=1 STRING: ENSP00000296084
TRAK1	Q9UPV9³, ENSP00000328998⁴	I2D: score=1 STRING: ENSP00000328998
BECN1	Q14457³	I2D: score=1
CLN3	Q13286³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IMP	12482879
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0019725	cellular homeostasis	IMP	12482879
GO:0047497	mitochondrion transport along microtubule	IMP	16630562
GO:0051056	regulation of small GTPase mediated signal transduction	TAS	--

RHOT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RHOT2
Search CenterWatch for drugs/clinical trials and news about RHOT2 / MIRO2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RHOT2 gene:

NM_138769.2

Unigene Cluster for RHOT2:

Ras homolog family member T2

Hs.513242 [show with all ESTs]

Unigene Representative Sequence: NM_138769

18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000315082(uc002cip.3) ENST00000563776 ENST00000561983 ENST00000563134

ENST00000562708 ENST00000570092 ENST00000569706 ENST00000569675(uc002ciq.3)

ENST00000566214 ENST00000563637 ENST00000570280 ENST00000567017 ENST00000568950

ENST00000562693(uc010uum.2) ENST00000562598 ENST00000562333 ENST00000561929

ENST00000569943

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOT2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOT2:
		hsa-miR-4324 hsa-miR-125a-5p hsa-miR-125b hsa-miR-4251 hsa-miR-580 hsa-miR-4319
		SwitchGear 3'UTR luciferase reporter plasmid: RHOT2 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOT2

Additional cDNA sequence:

AJ517413.1 AY207375.1 BC004327.1 BC014942.1

23 DOTS entries:

DT.454981 DT.100664976 DT.100060292 DT.100764328 DT.95362540 DT.95362541 DT.92437469 DT.120689950

DT.91950447 DT.92437468 DT.97854144 DT.100060307 DT.100664982 DT.120689947 DT.95362533 DT.100664981

DT.100664983 DT.100838352 DT.100866523 DT.92437466 DT.92437467 DT.95362537 DT.100808775

24/353 AceView cDNA sequences (see all 353):

BF589052 AI744390 BU538669 BQ070934 AW614811 AW082290 AI271948 CA435268

BM557970 BQ020309 BM695893 BU617082 BE277436 BX402013 BU617261 BI753096

AI697431 AI366516 AK024450 CR597322 CA487663 NM_138769 BQ917267 BQ069932

GeneLoc Exon Structure

5/33 Alternative Splicing Database (ASD) splice patterns (SP) for RHOT2 (see all 33) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c	·	9d	·	9e	^	10	^	11a	·	11b	·	11c	·	11d	^	12a	·
SP1:															-										-																								-
SP2:															-										-						-																		-
SP3:															-																																		-
SP4:															-										-																								-
SP5:															-										-						-												-		-		-		-

ExUns:	12b	·	12c	·	12d	^	13a	·	13b	^	14	^	15a	·	15b	^	16a	·	16b	^	17	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23a	·	23b	^	24a	·	24b	·	24c	·	24d	·	24e
SP1:																									-		-										-
SP2:																									-		-										-
SP3:
SP4:							-
SP5:

ECgene alternative splicing isoforms for RHOT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RHOT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTGGGGC

About this image
See RHOT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RHOT2

SOURCE GeneReport for Unigene cluster: Hs.513242

UniProtKB/Swiss-Prot: MIRO2_HUMAN, Q8IXI1

Tissue specificity: Ubiquitously expressed. Highly expressed in heart, liver, skeletal muscle, kidney and pancreas

SABiosciences Expression via Pathway-Focused PCR Array including RHOT2:

Mitochondria in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOT2 gene from 10/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rhot2^{1 , 5}	ras homolog gene family, member T2^{1, 5}	81.82(n)¹ 85.28(a)¹		17 (12.93 cM)⁵ 214952¹ NM_145999.2¹ NP_666111.1¹ 25838457⁵
chicken (Gallus gallus)	Aves	RHOT2¹	ras homolog gene family, member T2	74.74(n) 74.15(a)		427651 NM_001080866.1 NP_001074335.1
lizard (Anolis carolinensis)	Reptilia	RHOT2⁶	--	71(a)	1 ↔ 1	GL344132.1(26341-59433)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15769²	Xenopus laevis transcribed sequence with moderate similarity more	78.17(n)		BJ031050.1
zebrafish (Danio rerio)	Actinopterygii	rhot2¹	ras homolog gene family, member T2	66.78(n) 66.78(a)		557574 NM_001037679.1 NP_001032768.1
fruit fly (Drosophila melanogaster)	Insecta	Miro⁶	Mitochondrial Rho	45(a)	1 → many	3R(19860084-19864569)
worm (Caenorhabditis elegans)	Secernentea	K08F11.5⁶ C47C12.4⁶ (see all 3)	Protein C47C12.4 (see all 3)	43(a) 39(a) (see all 3)	many ↔ many many ↔ many (see all 3)	IV(4712818-4715801) X(7756650-7758103)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GEM1¹	Gem1p	42.99(n) 36.1(a)		851249 NP_009351.1
thale cress (Arabidopsis thaliana)	eudicotyledons	MIRO1¹	MIRO-related GTP-ase 1	45.34(n) 39.03(a)		832814 NM_001036876.1 NP_001031953.1
rice (Oryza sativa)	Liliopsida	Os.15115²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.01(n)		AK101920.1

ENSEMBL Gene Tree for RHOT2 (if available)
TreeFam Gene Tree for RHOT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RHOT2 gene

RHOT1²

4 SIMAP similar genes for RHOT2 using alignment to 8 protein entries: MIRO2_HUMAN (see all proteins):

RHOT1 RHOC CDC42 RHOA

RHOT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199958382^1,2		--	716156(+)	`GTGCCA/GTCCTG`	2	--	us2k¹ int¹		0	--	--	--	--
rs184391573^1,2	C,	--	716184(+)	`TCTCCA/GGGCTG`	2	--	int¹ us2k¹		0	--	--	--	--
rs189156518^1,2	C,	--	716189(+)	`GGGCTA/GGGGGC`	2	--	int¹ us2k¹		0	--	--	--	--
rs3743909^1,2	C,F,A,H,	--	716428(+)	`CACCTA/GTCGGC`	2	--	int¹ us2k¹		21		EA NS WA NA CSA EU	3598
rs117904014^1,2	C,F,	--	716631(+)	`GGGGCC/TGGTAC`	2	--	us2k¹ int¹		2		NA EU	1379
rs73487477^1,2	C,F,	--	716632(+)	`GGGCCG/AGTACC`	2	--	us2k¹ int¹		5		WA CSA EU	1382
rs12447392^1,2	C,F,H,	--	716798(+)	`GTACAC/TGCAGC`	2	--	int¹ us2k¹		3		NA EU	1405
rs7189028^1,2	C,F,A,H,	--	717057(+)	`CCCTGC/TTCCAA`	2	--	us2k¹ int¹		11		NA WA CSA EA	372
rs7197072^1,2	C,F,A,H,	--	717085(+)	`TGCCCC/TGGGCT`	2	--	int¹ us2k¹ tfbs³		7		NA WA EA	366
rs111924337^1,2		--	717231(+)	`GGGAAC/ATGGCC`	2	--	us2k¹ int¹		1		CSA	2

HapMap Linkage Disequilibrium report for RHOT2 (718086 - 724174 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for RHOT2
10 CNVs: 49727 53069 29986 49728 3987 29982 5329 30732 29983 29985

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RHOT2 for disorders           About GeneDecksing

OMIM gene information: 613889    OMIM disorders: --

1 disease for RHOT2:    About MalaCards

hypoxia

Human Genome Epidemiology (HuGE) Navigator: RHOT2 (1 document)

Export disorders for RHOT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RHOT2 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with RHOT2)

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Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PubMed id 12482879)^{1, 2, 3} Fransson A.... Aspenstroem P. (2003)
HUMMR, a hypoxia- and HIF-1alpha-inducible protein, a lters mitochondrial distribution and transport. (PubMed id 19528298)^{1, 2} Li Y....Rempe D.A. (2009)
The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PubMed id 16630562)^{1, 2} Fransson S.... Aspenstroem P. (2006)
Rho GTPases have diverse effects on the organization of the actin filament system. (PubMed id 14521508)^{1, 2} Aspenstroem P.... Saras J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase. (PubMed id 15218247)^{1, 2} Shan Y.... Yu L. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)^{1, 2} Daniels R.J....Higgs D.R. (2001)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89941	HGNC: 21169	AceView: RHOT2	Ensembl:ENSG00000140983	euGenes: HUgn89941
ECgene: RHOT2	H-InvDB: RHOT2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RHOT2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RHOT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RHOT2 gene:
Search GeneIP for patents involving RHOT2

GeneCards and IP:
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ras homolog family member T2

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ras homolog family member T2

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