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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOT1 Gene

protein-coding   GIFtS: 55
GCID: GC17P030470

ras homolog family member T1

(Previous names: ras homolog gene family, member T1 )
(Previous symbol: ARHT1)
 Explore 3 diseases affiliated with
RHOT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RHOT1    

Aliases
for RHOT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ras Homolog Family Member T11 2     Mitochondrial Rho (MIRO) GTPase 12
ARHT11 2 3     Mitochondrial Rho 12
MIRO-11 2 3     Mitochondrial Rho GTPase 12
Ras Homolog Gene Family, Member T11 2     Rac-GTP Binding Protein-Like Protein2
Rac-GTP-Binding Protein-Like Protein2 3     EC 3.6.5.-3
HMiro-11     Ras Homolog Gene Family Member T13
FLJ110401     EC 3.6.58
MIRO12     

External Ids:    HGNC: 211681   Entrez Gene: 552882   Ensembl: ENSG000001268587   OMIM: 6138885   UniProtKB: Q8IXI23   

Export aliases for RHOT1 gene to outside databases

Previous GC identifers: GC17P030616 GC17P027493 GC17P026657


Summaries
for RHOT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde
transport of mitochondria and their subcellular distribution

Gene Wiki entry for RHOT1


Genomic Views
for RHOT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOT1 gene promoter:
         AhR   SRF   SRF (504 AA)   HTF   FOXD1   FOXO3b   Arnt   SRY   HFH-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHOT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2-q12

RHOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOT1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P030470:  view genomic region     (about GC identifiers)

Start:
 30,469,473 bp from pter      End:
 30,580,393 bp from pter
Size:
 110,921 bases      Orientation:
 plus strand

Proteins
for RHOT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2 (See protein sequence)
Recommended Name: Mitochondrial Rho GTPase 1  
Size: 618 amino acids; 70784 Da
Subunit: Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria
and the trafficking apparatus of the microtubules
Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP
and RHOT2 at the mitochondria
Sequence caution: Sequence=AAH41114.1; Type=Erroneous initiation; Sequence=AAH68463.1; Type=Erroneous initiation;
Sequence=BAA91969.1; Type=Erroneous initiation; Sequence=BAB14185.1; Type=Erroneous initiation;
Secondary accessions: A4FVB6 A6NFV0 B4DG48 Q6NUR3 Q6P9F8 Q6PJG1 Q6YMW8 Q86UB0 Q8IW28 Q8IXJ7 Q9H067
Q9H9N8 Q9NUZ2
Alternative splicing: 6 isoforms:  Q8IXI2-1   Q8IXI2-2   Q8IXI2-3   Q8IXI2-4   Q8IXI2-5   Q8IXI2-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHOT1: NX_Q8IXI2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IXI2

    • 4/26 DME Specific Peptides for RHOT1 (Q8IXI2) (see all 26)
     ILPIMNQ  CTTELNH  DFCRKHK  GWITYQG 

    RHOT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028738.1  NP_001028740.1  NP_060777.3  

    ENSEMBL proteins: 
     ENSP00000334724   ENSP00000351132   ENSP00000462698   ENSP00000439737   ENSP00000346215  
     ENSP00000464094   ENSP00000462669   ENSP00000462612   ENSP00000378184   ENSP00000464851  
     ENSP00000463532   ENSP00000467272   ENSP00000464674   ENSP00000461992  
    Reactome Protein details: Q8IXI2
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: RHOT1
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    Novus Biologicals RHOT1 Proteins
    Novus Biologicals RHOT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RHOT1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0031307integral to mitochondrial outer membrane IDA19528298


    RHOT1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RHOT1

    Protein Domains /
    Families
    for RHOT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RHOT1 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR011992 EF-hand-like_dom
     IPR013566 EF_hand_assoc_1
     IPR002048 EF_hand_Ca-bd
     IPR013684 MIRO-like
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8IXI2

    ProtoNet protein and cluster: Q8IXI2

    4 Blocks protein families:
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase
    IPB013567 EF hand associated
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
    Similarity: Belongs to the mitochondrial Rho GTPase family
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 2 Miro domains


    Function
    for RHOT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
    Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde
    transport of mitochondria and their subcellular distribution

    Enzyme Numbers (IUBMB): EC 3.6.52 EC 3.6.5.-1

    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOT1 (see all 32):
    hsa-miR-623 hsa-miR-142-5p hsa-miR-548j hsa-miR-3938 hsa-miR-429 hsa-miR-520d-5p hsa-miR-548i hsa-miR-509-5p
    SwitchGear 3'UTR luciferase reporter plasmid: RHOT1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003924GTPase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--


    RHOT1 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Rhot1):
     mortality/aging 

    RHOT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RHOT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell death signalling via NRAGE, NRIF and NADE
    		Signaling by Rho GTPases0.25
    		Rho GTPase cycle0.25
    2Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for RHOT1
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    RHOT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHOT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/64 Interacting proteins for RHOT1 (Q8IXI21, 3 ENSP000003511324) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAK1Q9UPV91, 3, ENSP000003289984EBI-1396430,EBI-1105048 I2D: score=5 STRING: ENSP00000328998
    KIF5CO602821, 3, ENSP000003933794EBI-1396430,EBI-717170 I2D: score=1 STRING: ENSP00000393379
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    ATP5A1P257053, ENSP000002820504I2D: score=1 STRING: ENSP00000282050
    CAPZA2P477553, ENSP000003549474I2D: score=1 STRING: ENSP00000354947
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IMP12482879
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0019725cellular homeostasis IMP12482879
    GO:0047497mitochondrion transport along microtubule IMP16630562
    GO:0051056regulation of small GTPase mediated signal transduction TAS--


    RHOT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RHOT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOT1

    1 HMDB Compound for RHOT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about RHOT1 / MIRO1 

    Transcripts
    for RHOT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RHOT1 gene (4 alternative transcripts): 
    NM_001033567.1  NM_001033566.1  NM_001033568.1  NM_018307.3  

    Unigene Cluster for RHOT1:

    Ras homolog family member T1
    Hs.655325  [show with all ESTs]
    Unigene Representative Sequence: NM_001033568
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333942(uc002hgz.3 uc002hhb.3) ENST00000358365(uc002hgw.3 uc002hgy.3 uc010csv.3 uc010wby.2)
    ENST00000583994(uc002hha.3 uc002hgx.3) ENST00000545287 ENST00000354266
    ENST00000581031 ENST00000581094(uc002hgv.3) ENST00000578205 ENST00000580976
    ENST00000394692 ENST00000582602 ENST00000581567 ENST00000580392 ENST00000581148
    ENST00000584692 ENST00000584852 ENST00000582586

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOT1
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOT1 (see all 32):
    hsa-miR-623 hsa-miR-142-5p hsa-miR-548j hsa-miR-3938 hsa-miR-429 hsa-miR-520d-5p hsa-miR-548i hsa-miR-509-5p
    SwitchGear 3'UTR luciferase reporter plasmid: RHOT1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RHOT1 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOT1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): RHOT1 (NM_018307)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOT1

    Additional cDNA sequence: 

    AJ496730.1 AJ517412.1 AK001902.1 AK022695.1 AK294407.1 AL117543.1 AL136929.1 AY094972.1 
    BC015698.2 BC029029.1 BC041114.1 BC051818.1 BC060781.1 BC092401.1 BC110895.1 BC125104.1 
    BC125105.1 

    20 DOTS entries:

    DT.87016523  DT.100777598  DT.100777602  DT.92439129  DT.97795281  DT.100777603  DT.100686976  DT.100777600 
    DT.111227  DT.120955652  DT.95169554  DT.92439132  DT.100035483  DT.120955513  DT.92439135  DT.95169551 
    DT.95359655  DT.99978228  DT.40209185  DT.97845014 

    24/245 AceView cDNA sequences (see all 245):

    AA707923 AL527595 AJ517412 Z45463 BM069542 AI199847 AL136929 BM661631 
    AA280974 AK001902 AJ496730 AW268712 BF589168 N23495 BG575589 BM840305 
    NM_018307 F07768 AA453078 CA418104 AK022695 BE502492 AI453068 BI966168 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RHOT1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                                -                 -     -   
    SP3:                                                                                                                                -                 -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                -                 -         

    ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e
    SP1:                                    
    SP2:  -                                 
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RHOT1

    Expression
    for RHOT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAAACCTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RHOT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOT1

    SOURCE GeneReport for Unigene cluster: Hs.655325

    UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
    Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including RHOT1: 
              Mitochondria in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for RHOT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RHOT1 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RHOT11 ras homolog gene family, member T1 84.79(n)
    94.01(a)    		   417410  NM_001006208.1  NP_001006208.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RHOT16
    		 --
    		 91(a)
    		 1 ↔ 1
    		 GL343198.1(1580161-1620334)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.66392 Danio rerio mRNA similar to RIKEN cDNA 2210403N23 gene (cDNA clone MGC55581 IMAGE2643358), complete cds less 76.79(n)    BC044431.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Miro1 Mitochondrial Rho 55.74(n)
    54.04(a)    		   42845  NM_170111.2  NP_732936.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea miro-21 Protein MIRO-2 54.17(n)
    48.12(a)    		   183540  NM_076909.1  NP_509310.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MIRO21 MIRO-related GTP-ase 2 48.9(n)
    41.29(a)    		   825490  NM_116180.3  NP_567139.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 ATP/GTP/Ca++ binding protein, putative, expressed
    (see all 3)    		 36(a)
    35(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 3(33929025-33930842)
    3(33920457-33926735)


    ENSEMBL Gene Tree for RHOT1 (if available)
    TreeFam Gene Tree for RHOT1 (if available) 

    Paralogs
    for RHOT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOT1 gene
    RHOT22  
    1 SIMAP similar gene for RHOT1 using alignment to 10 protein entries:     MIRO1_HUMAN (see all proteins):
    RHOT2

    RHOT1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RHOT1
    PGOHUM00000248294 PGOHUM00000235011 PGOHUM00000239031


    Genomic Variants
    for RHOT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1414 NCBI SNPs in RHOT1 are shown (see all 1414)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs579713301,2
    		--26693507(+) ACCCCA/GTCTAG 1 -- ds50010--------
    rs65052851,2
    		C,F,A,--26693525(+) ggagcA/Gtctct 1 -- ds50015Minor allele frequency- G:0.33NA CSA 9
    rs72167731,2
    		C,--26693900(+) gggaaC/Gtgagg 1 -- nc-transcript-variant0--------
    rs80685021,2
    		C,--26694153(+) gccccA/Gtctgg 1 -- nc-transcript-variant0--------
    rs72123171,2
    		C,--26694738(+) ggagcA/Gcctct 1 -- nc-transcript-variant0--------
    rs72141731,2
    		C,--26694744(+) cctctA/Gcctgg 1 -- nc-transcript-variant0--------
    rs3013471,2
    		A,--26695222(+) cttggG/Aatgct 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs732861521,2
    		C,--26696125(+) TTTTCC/GCCACA 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs732861531,2
    		C,--26696687(+) AATAAA/GACCTA 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs732861541,2
    		C,--26696790(+) CTGTAG/CCCATT 1 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for RHOT1 (30469473 - 30580393 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RHOT1
         1 CNV: 4030

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    Disorders / Diseases
    for RHOT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RHOT1 for disorders           About GeneDecksing

    OMIM gene information: 613888    OMIM disorders: --

    3 diseases for RHOT1:    About MalaCards
    optic atrophy    neuronitis    hypoxia

    Human Genome Epidemiology (HuGE) Navigator: RHOT1 (2 documents)

    Export disorders for RHOT1 gene to outside databases

    Publications
    for RHOT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOT1 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with RHOT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PubMed id 12482879)1, 2, 3 Fransson A.... Aspenstroem P. (2003)
    2. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, a lters mitochondrial distribution and transport. (PubMed id 19528298)1, 2 Li Y....Rempe D.A. (2009)
    3. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PubMed id 16630562)1, 2 Fransson S.... Aspenstroem P. (2006)
    4. Rho GTPases have diverse effects on the organization of the actin filament system. (PubMed id 14521508)1, 2 Aspenstroem P.... Saras J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    9. Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. (PubMed id 22396657)1 Liu S....Lu B. (2012)
    10. Voltage-dependent anion channels (VDACs) recruit Parki n to defective mitochondria to promote mitochondrial autophagy. (PubMed id 23060438)1 Sun Y....Dreier L. (2012)

    External Searches for RHOT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RHOT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55288 HGNC: 21168 AceView: RHOT1 Ensembl:ENSG00000126858 euGenes: HUgn55288
    ECgene: RHOT1 H-InvDB: RHOT1

    Other Databases showing RHOT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RHOT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOT1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RHOT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RHOT1 gene:
    Search GeneIP for patents involving RHOT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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