Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOT1 Gene

protein-coding   GIFtS: 59
GCID: GC17P030470

Ras Homolog Family Member T1

(Previous names: ras homolog gene family, member T1)
(Previous symbol: ARHT1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Homolog Family Member T11 2     MIRO12
ARHT11 2 3     Mitochondrial Rho 12
Ras Homolog Gene Family, Member T11 2     Mitochondrial Rho GTPase 12
Mitochondrial Rho (MIRO) GTPase 11 2     Rac-GTP Binding Protein-Like Protein2
Rac-GTP-Binding Protein-Like Protein2 3     EC 3.6.5.-3
MIRO-12 3     Ras Homolog Gene Family Member T13
hMiro-12 3     EC 3.6.58

External Ids:    HGNC: 211681   Entrez Gene: 552882   Ensembl: ENSG000001268587   OMIM: 6138885   UniProtKB: Q8IXI23   

Export aliases for RHOT1 gene to outside databases

Previous GC identifers: GC17P030616 GC17P027493 GC17P026657


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RHOT1 Gene: 
RHOT1 (ras homolog family member T1) is a protein-coding gene. Diseases associated with RHOT1 include optic atrophy, and parkinson's disease, and among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include GTP binding and molecular_function. An important paralog of this gene is RHOT2.

UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde
transport of mitochondria and their subcellular distribution

Gene Wiki entry for RHOT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOT1 gene promoter:
         AhR   SRF   SRF (504 AA)   HTF   FOXD1   FOXO3b   Arnt   SRY   HFH-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2-q12

RHOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOT1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P030470:  view genomic region     (about GC identifiers)

Start:
30,469,473 bp from pter      End:
30,580,393 bp from pter
Size:
110,921 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2 (See protein sequence)
Recommended Name: Mitochondrial Rho GTPase 1  
Size: 618 amino acids; 70784 Da
Subunit: Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between
mitochondria and the trafficking apparatus of the microtubules
Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with
MGARP and RHOT2 at the mitochondria
Sequence caution: Sequence=AAH41114.1; Type=Erroneous initiation; Sequence=AAH68463.1; Type=Erroneous initiation;
Sequence=BAA91969.1; Type=Erroneous initiation; Sequence=BAB14185.1; Type=Erroneous initiation;
Secondary accessions: A4FVB6 A6NFV0 B4DG48 J9JIH9 Q6NUR3 Q6P9F8 Q6PJG1 Q6YMW8 Q86UB0 Q8IW28
Q8IXJ7 Q9H067 Q9H9N8 Q9NUZ2
Alternative splicing: 7 isoforms:  Q8IXI2-1   Q8IXI2-2   Q8IXI2-3   Q8IXI2-4   Q8IXI2-5   Q8IXI2-6   Q8IXI2-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHOT1: NX_Q8IXI2

Explore proteomics data for RHOT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IXI2

  • 4/26 DME Specific Peptides for RHOT1 (Q8IXI2) (see all 26)
     ILPIMNQ  CTTELNH  DFCRKHK  GWITYQG 

    RHOT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RHOT1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001028738.1  NP_001028740.1  NP_060777.3  

    ENSEMBL proteins: 
     ENSP00000334724   ENSP00000351132   ENSP00000462698   ENSP00000439737   ENSP00000346215  
     ENSP00000464094   ENSP00000462669   ENSP00000462612   ENSP00000378184   ENSP00000464851  
     ENSP00000463532   ENSP00000467272   ENSP00000464674   ENSP00000461992  
    Reactome Protein details: Q8IXI2
    Human Recombinant Protein Products for RHOT1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RHOT1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RHOT1
    GenScript Custom Purified and Recombinant Proteins Services for RHOT1
    Novus Biologicals RHOT1 Proteins
    Novus Biologicals RHOT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHOT1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    RHOT1 for ontologies           About GeneDecksing



    RHOT1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RHOT1
    GenScript Custom Superior Antibodies Services for RHOT1
    Novus Biologicals RHOT1 Antibodies
    Abcam antibodies for RHOT1
    Cloud-Clone Corp. Antibodies for RHOT1 
    Search ThermoFisher Antibodies for RHOT1
    LSBio Antibodies in human, mouse, rat for RHOT1 

    Assay Products for RHOT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RHOT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RHOT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOT1 
    Cloud-Clone Corp. CLIAs for RHOT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/11 InterPro protein domains (see all 11):
     IPR011992 EF-hand-like_dom
     IPR013566 EF_hand_assoc_1
     IPR002048 EF_hand_dom
     IPR013684 MIRO-like
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8IXI2

    ProtoNet protein and cluster: Q8IXI2

    4 Blocks protein domains:
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase
    IPB013567 EF hand associated
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
    Similarity: Belongs to the mitochondrial Rho GTPase family
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 2 Miro domains


    RHOT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIRO1_HUMAN, Q8IXI2
    Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde
    transport of mitochondria and their subcellular distribution

         Enzyme Numbers (IUBMB): EC 3.6.52 EC 3.6.5.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003924GTPase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16630562
    GO:0005525GTP binding IEA--
         
    RHOT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rhot1):
     mortality/aging 

    RHOT1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RHOT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RHOT1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOT1
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOT1 (see all 32):
    hsa-miR-623 hsa-miR-142-5p hsa-miR-548j hsa-miR-3938 hsa-miR-429 hsa-miR-520d-5p hsa-miR-548i hsa-miR-509-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOT1
    Sirion Biotech Customized adenovirus for overexpression of RHOT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RHOT1 (see all 16)
    OriGene ORF clones in mouse, rat for RHOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RHOT1 (NM_018307)
    Sino Biological Human cDNA Clone for RHOT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOT1
    Sirion Biotech Customized lentivirus for stable overexpression of RHOT1 
                         Customized lentivirus expression plasmids for stable overexpression of RHOT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RHOT1
    Search LifeMap BioReagents cell lines for RHOT1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RHOT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for RHOT1
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle



    RHOT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RHOT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/64 Interacting proteins for RHOT1 (Q8IXI21, 3 ENSP000003511324) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAK1Q9UPV91, 3, ENSP000003289984EBI-1396430,EBI-1105048 I2D: score=5 STRING: ENSP00000328998
    KIF5CO602821, 3, ENSP000003933794EBI-1396430,EBI-717170 I2D: score=1 STRING: ENSP00000393379
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    ATP5A1P257053, ENSP000002820504I2D: score=1 STRING: ENSP00000282050
    CAPZA2P477553, ENSP000003549474I2D: score=1 STRING: ENSP00000354947
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport ----
    GO:0019725cellular homeostasis IMP12482879

    RHOT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RHOT1 (MIRO1)

    1 HMDB Compound for RHOT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RHOT1 / MIRO1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RHOT1 gene (4 alternative transcripts): 
    NM_001033567.1  NM_001033566.1  NM_001033568.1  NM_018307.3  

    Unigene Cluster for RHOT1:

    Ras homolog family member T1
    Hs.655325  [show with all ESTs]
    Unigene Representative Sequence: NM_001033568
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333942(uc002hgz.3 uc002hhb.3) ENST00000358365(uc002hgw.3 uc002hgy.3 uc010csv.3 uc010wby.2)
    ENST00000583994(uc002hha.3 uc002hgx.3) ENST00000545287 ENST00000354266
    ENST00000581031 ENST00000581094(uc002hgv.3) ENST00000578205 ENST00000580976
    ENST00000394692 ENST00000582602 ENST00000581567 ENST00000580392 ENST00000581148
    ENST00000584692 ENST00000584852 ENST00000582586

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOT1
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOT1 (see all 32):
    hsa-miR-623 hsa-miR-142-5p hsa-miR-548j hsa-miR-3938 hsa-miR-429 hsa-miR-520d-5p hsa-miR-548i hsa-miR-509-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RHOT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOT1
    Clone
    Products:
         
    OriGene clones in human, mouse for RHOT1 (see all 16)
    OriGene ORF clones in mouse, rat for RHOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RHOT1 (NM_018307)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOT1
    Sirion Biotech Customized lentivirus for stable overexpression of RHOT1 
                         Customized lentivirus expression plasmids for stable overexpression of RHOT1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOT1
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOT1

    Additional mRNA sequence: 

    AJ496730.1 AJ517412.1 AK001902.1 AK022695.1 AK294407.1 AL117543.1 AL136929.1 AY094972.1 
    BC015698.2 BC029029.1 BC041114.1 BC051818.1 BC060781.1 BC092401.1 BC110895.1 BC125104.1 
    BC125105.1 

    20 DOTS entries:

    DT.87016523  DT.100777598  DT.100777602  DT.92439129  DT.97795281  DT.100777603  DT.100686976  DT.100777600 
    DT.111227  DT.120955652  DT.95169554  DT.92439132  DT.100035483  DT.120955513  DT.92439135  DT.95169551 
    DT.95359655  DT.99978228  DT.40209185  DT.97845014 

    24/245 AceView cDNA sequences (see all 245):

    BM661631 AI768147 BG612402 AY094972 F04328 BP339916 AI199847 BM069542 
    AA011444 AA452910 BC051818 F07768 AI073884 AW268712 AI003641 AU279544 
    AI436247 CA433419 AI453068 AJ496730 AI275839 BE220856 AA251688 BC041114 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RHOT1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                                -                 -     -   
    SP3:                                                                                                                                -                 -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                -                 -         

    ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e
    SP1:                                    
    SP2:  -                                 
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RHOT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOT1 expression in normal human tissues (normalized intensities)      RHOT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAACCTAT
    RHOT1 Expression
    About this image


    RHOT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
             breast epithelium   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Breast
             breast ; myoepithelial cells   
             breast epithelium   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See RHOT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOT1

    SOURCE GeneReport for Unigene cluster: Hs.655325

    UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
    Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including RHOT1: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHOT1
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RHOT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RHOT1 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhot11 , 5 ras homolog gene family, member T11, 5 92.29(n)1
    97.9(a)1
      11 (47.62 cM)5
    590401  NM_021536.71  NP_067511.41 
     802090195 
    chicken
    (Gallus gallus)
    Aves RHOT11 ras homolog gene family, member T1 84.79(n)
    94.01(a)
      417410  NM_001006208.1  NP_001006208.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOT16
    Mitochondrial Rho GTPase
    93(a)
    1 ↔ 1
    GL343198.1(1580161-1622766)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.66392 Danio rerio mRNA similar to RIKEN cDNA 2210403N23 gene (cDNA clone MGC55581 IMAGE2643358), complete cds less 76.79(n)    BC044431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Miro1 Mitochondrial Rho 55.74(n)
    54.04(a)
      42845  NM_170111.2  NP_732936.1 
    worm
    (Caenorhabditis elegans)
    Secernentea miro-21 Protein MIRO-2 54.17(n)
    48.12(a)
      183540  NM_076909.1  NP_509310.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GEM1(YAL048C)4 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death less   --   1(54789-52801) 851249  NP_009351.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MIRO21 MIRO-related GTP-ase 2 48.9(n)
    41.29(a)
      825490  NM_116180.3  NP_567139.1 


    ENSEMBL Gene Tree for RHOT1 (if available)
    TreeFam Gene Tree for RHOT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOT1 gene
    RHOT22  
    1 SIMAP similar gene for RHOT1 using alignment to 9 protein entries:     MIRO1_HUMAN (see all proteins):
    RHOT2

    RHOT1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RHOT1
    PGOHUM00000248294 PGOHUM00000235011 PGOHUM00000239031


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1501 SNPs in RHOT1 are shown (see all 1501)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346731871,2
    C,F--30467516(+) TTTTTT/-ATCTA 3 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs1167569861,2
    C,F--30467562(+) AGCTCT/CGTCAG 3 -- us2k11Minor allele frequency- C:0.06WA 118
    rs129426241,2
    H--30467695(+) GAGATG/TAAAGC 3 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1856977451,2
    --30467790(+) TAACAC/TGGACA 3 -- us2k10--------
    rs739897061,2
    C,F--30467802(+) GGATAG/AAGTTG 3 -- us2k13Minor allele frequency- A:0.50WA CSA 6
    rs1381796971,2
    C--30467913(+) GTGGAA/TTAGGC 3 -- us2k10--------
    rs1427697641,2
    C--30468024(+) AACCCC/TGTCTC 3 -- us2k10--------
    rs1820233951,2
    --30468215(+) AAAACA/CAAACC 3 -- us2k10--------
    rs1460806261,2
    C--30468224(+) CCAAAA/CCAAAA 3 -- us2k10--------
    rs72088381,2
    C,F,A,H--30468566(+) GTTGGT/CATTAC 3 -- us2k119Minor allele frequency- C:0.29NS EA NA WA 2338

    HapMap Linkage Disequilibrium report for RHOT1 (30469473 - 30580393 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RHOT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669243CNV Deletion23128226
    nsv908067CNV Gain21882294
    nsv908068CNV Gain21882294
    dgv944e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOT1
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613888    OMIM disorders: --

    6 diseases for RHOT1:    About MalaCards
    optic atrophy    parkinson's disease    hypoxia    pancreatic cancer
    pancreatitis    neuronitis


    RHOT1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): RHOT1
    Human Genome Epidemiology (HuGE) Navigator: RHOT1 (2 documents)

    Export disorders for RHOT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOT1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RHOT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PubMed id 12482879)1, 2, 3 Fransson A.... Aspenstroem P. (2003)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, a lters mitochondrial distribution and transport. (PubMed id 19528298)1, 2 Li Y....Rempe D.A. (2009)
    5. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PubMed id 16630562)1, 2 Fransson S.... Aspenstroem P. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Rho GTPases have diverse effects on the organization of the actin filament system. (PubMed id 14521508)1, 2 Aspenstroem P.... Saras J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55288 HGNC: 21168 AceView: RHOT1 Ensembl:ENSG00000126858 euGenes: HUgn55288
    ECgene: RHOT1 H-InvDB: RHOT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RHOT1 gene:
    Search GeneIP for patents involving RHOT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RHOT1  
     OriGene qPCR primer pairs and template standards for RHOT1   OriGene Protein Over-expression Lysate for RHOT1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RHOT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RHOT1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RHOT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RHOT1   OriGene Custom Protein Services for RHOT1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RHOT1
     QIAGEN SeqTarget long-range PCR primers for resequencing RHOT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RHOT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RHOT1
     GenScript Custom Purified and Recombinant Proteins Services for RHOT1 GenScript cDNA clones with any tag delivered in your preferred vector for RHOT1
     GenScript Custom Assay Services for RHOT1 GenScript Custom Superior Antibodies Services for RHOT1
     GenScript Custom overexpressing Cell Line Services for RHOT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RHOT1 promoter
     Search Chromatin IP Primers for RHOT1
     RT2 qPCR Primer Assay in human, mouse, rat RHOT1
     Search GNC Networks for RHOT1
     SABiosciences PCR Arrays including human, mouse, rat RHOT1
     Search Tocris compounds for RHOT1 (MIRO1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for RHOT1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RHOT1 antibodies
     RHOT1 proteins
     RHOT1 lysates
     Antibodies for RHOT1
     See all of Abcam's Antibodies, Kits and Proteins for RHOT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RHOT1
     Antibodies for RHOT1
     ELISAs for RHOT1
     CLIAs for RHOT1
     Search LifeMap BioReagents cell lines for RHOT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOT1
     SwitchGear 3'UTR luciferase reporter plasmids for RHOT1
     SwitchGear Promoter luciferase reporter plasmids for RHOT1
     Search ThermoFisher Antibodies for RHOT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOT1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RHOT1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RHOT1
    Customized:
     lentivirus for stable overexpression of RHOT1
     lentivirus expression plasmids for stable overexpression of RHOT1
     adenovirus for overexpression of RHOT1
     LSBio Antibodies in human, mouse, rat for RHOT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RHOT1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4