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Aliases for RHOT1 Gene

Aliases for RHOT1 Gene

  • Ras Homolog Family Member T1 2 3
  • ARHT1 3 4 6
  • Ras Homolog Gene Family, Member T1 2 3
  • Mitochondrial Rho (MIRO) GTPase 1 2 3
  • MIRO-1 3 4
  • MIRO1 3 6
  • Rac-GTP Binding Protein-Like Protein 3
  • Rac-GTP-Binding Protein-Like Protein 4
  • Ras Homolog Gene Family Member T1 4
  • Mitochondrial Rho GTPase 1 3
  • EC 3.6.5.- 4
  • EC 3.6.5 64
  • HMiro-1 4

External Ids for RHOT1 Gene

Previous Symbols for RHOT1 Gene

  • ARHT1

Summaries for RHOT1 Gene

GeneCards Summary for RHOT1 Gene

RHOT1 (Ras Homolog Family Member T1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT2.

UniProtKB/Swiss-Prot for RHOT1 Gene

  • Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Gene Wiki entry for RHOT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOT1 Gene

Genomics for RHOT1 Gene

Genomic Location for RHOT1 Gene

Start:
32,142,454 bp from pter
End:
32,253,374 bp from pter
Size:
110,921 bases
Orientation:
Plus strand

Genomic View for RHOT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOT1 Gene

Regulatory Elements for RHOT1 Gene

Proteins for RHOT1 Gene

  • Protein details for RHOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXI2-MIRO1_HUMAN
    Recommended name:
    Mitochondrial Rho GTPase 1
    Protein Accession:
    Q8IXI2
    Secondary Accessions:
    • A4FVB6
    • A6NFV0
    • B4DG48
    • J9JIH9
    • Q6NUR3
    • Q6P9F8
    • Q6PJG1
    • Q6YMW8
    • Q86UB0
    • Q8IW28
    • Q8IXJ7
    • Q9H067
    • Q9H9N8
    • Q9NUZ2

    Protein attributes for RHOT1 Gene

    Size:
    618 amino acids
    Molecular mass:
    70784 Da
    Quaternary structure:
    • Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules.
    SequenceCaution:
    • Sequence=AAH41114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH68463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14185.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOT1 Gene

neXtProt entry for RHOT1 Gene

Proteomics data for RHOT1 Gene at MOPED

Post-translational modifications for RHOT1 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys153, Lys187, and Lys194

Domains for RHOT1 Gene

Gene Families for RHOT1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

UniProtKB/Swiss-Prot:

MIRO1_HUMAN
Domain:
  • Contains 2 EF-hand domains.:
    • Q8IXI2
  • Contains 2 Miro domains.:
    • Q8IXI2
Family:
  • Belongs to the mitochondrial Rho GTPase family.:
    • Q8IXI2
genes like me logo Genes that share domains with RHOT1: view

Function for RHOT1 Gene

Molecular function for RHOT1 Gene

UniProtKB/Swiss-Prot Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Enzyme Numbers (IUBMB) for RHOT1 Gene

Gene Ontology (GO) - Molecular Function for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16630562
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOT1: view

Phenotypes for RHOT1 Gene

MGI mutant phenotypes for RHOT1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RHOT1: view

miRNA for RHOT1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RHOT1 Gene

Localization for RHOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOT1 Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOT1 Gene COMPARTMENTS Subcellular localization image for RHOT1 gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 4
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion NAS 22078885
GO:0005741 mitochondrial outer membrane --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOT1: view

Pathways for RHOT1 Gene

genes like me logo Genes that share pathways with RHOT1: view

Pathways by source for RHOT1 Gene

Gene Ontology (GO) - Biological Process for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008152 metabolic process IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RHOT1: view

Compounds for RHOT1 Gene

(1) HMDB Compounds for RHOT1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with RHOT1: view

Transcripts for RHOT1 Gene

Unigene Clusters for RHOT1 Gene

Ras homolog family member T1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7: - -
SP8: -
SP9:

ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:

Relevant External Links for RHOT1 Gene

GeneLoc Exon Structure for
RHOT1
ECgene alternative splicing isoforms for
RHOT1

Expression for RHOT1 Gene

mRNA expression in normal human tissues for RHOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOT1 Gene

SOURCE GeneReport for Unigene cluster for RHOT1 Gene Hs.655325

mRNA Expression by UniProt/SwissProt for RHOT1 Gene

Q8IXI2-MIRO1_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle.
genes like me logo Genes that share expressions with RHOT1: view

Orthologs for RHOT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOT1 36
  • 99.43 (n)
  • 99.85 (a)
RHOT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RHOT1 36
  • 94.77 (n)
  • 98.87 (a)
RHOT1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOT1 36
  • 95.4 (n)
  • 98.79 (a)
RHOT1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhot1 36
  • 92.72 (n)
  • 98.03 (a)
Rhot1 16
Rhot1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOT1 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOT1 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhot1 36
  • 92.18 (n)
  • 97.57 (a)
chicken
(Gallus gallus)
Aves RHOT1 36
  • 84.74 (n)
  • 94.01 (a)
RHOT1 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOT1 37
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492251 36
  • 74.7 (n)
  • 85.76 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.6639 36
RHOT1 (3 of 3) 37
  • 85 (a)
OneToMany
rhot1a 36
  • 74.49 (n)
  • 86.08 (a)
rhot1a 37
  • 86 (a)
OneToMany
rhot1b 37
  • 79 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007998 36
  • 55.57 (n)
  • 56.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Miro 36
  • 56.08 (n)
  • 55.73 (a)
Miro 37
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea miro-1 36
  • 51.85 (n)
  • 45.85 (a)
miro-1 37
  • 44 (a)
ManyToMany
miro-2 37
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEM1 37
  • 30 (a)
OneToMany
GEM1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons MIRO2 36
  • 48.94 (n)
  • 41.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToMany
Species with no ortholog for RHOT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOT1 Gene

ENSEMBL:
Gene Tree for RHOT1 (if available)
TreeFam:
Gene Tree for RHOT1 (if available)

Paralogs for RHOT1 Gene

Paralogs for RHOT1 Gene

Selected SIMAP similar genes for RHOT1 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for RHOT1 Gene

genes like me logo Genes that share paralogs with RHOT1: view

Variants for RHOT1 Gene

Sequence variations from dbSNP and Humsavar for RHOT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs172523 -- 32,206,107(-) AAGGA(A/G)ACGGG intron-variant
rs184201 -- 32,214,895(-) aaaaa(A/G)GACAA intron-variant
rs188534 -- 32,206,435(-) AAAGT(A/T)TAGAC intron-variant
rs301342 -- 32,222,772(-) AGCTA(C/T)CCGGG intron-variant
rs301345 -- 32,229,740(-) aggtt(G/T)cagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOT1 Gene

Variant ID Type Subtype PubMed ID
dgv944e1 CNV Complex 17122850
nsv908067 CNV Gain 21882294
esv2669243 CNV Deletion 23128226
nsv908068 CNV Gain 21882294

Relevant External Links for RHOT1 Gene

HapMap Linkage Disequilibrium report
RHOT1

Disorders for RHOT1 Gene

Relevant External Links for RHOT1

Genetic Association Database (GAD)
RHOT1
Human Genome Epidemiology (HuGE) Navigator
RHOT1
genes like me logo Genes that share disorders with RHOT1: view

No data available for UniProtKB/Swiss-Prot for RHOT1 Gene

Publications for RHOT1 Gene

  1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PMID: 12482879) Fransson A. … Aspenstroem P. (J. Biol. Chem. 2003) 2 3 4
  2. Rho GTPases have diverse effects on the organization of the actin filament system. (PMID: 14521508) Aspenstroem P. … Saras J. (Biochem. J. 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RHOT1 Gene

Sources for RHOT1 Gene

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