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RHOT1 Gene

protein-coding   GIFtS: 60
GCID: GC17P030470

Ras Homolog Family Member T1

(Previous names: ras homolog gene family, member T1)
(Previous symbol: ARHT1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Homolog Family Member T11 2     Rac-GTP Binding Protein-Like Protein2
ARHT11 2 3 5     EC 3.6.5.-3
Ras Homolog Gene Family, Member T11 2     hMiro-13
Mitochondrial Rho (MIRO) GTPase 11 2     Rac-GTP-Binding Protein-Like Protein3
MIRO-12 3     Ras Homolog Gene Family Member T13
MIRO12 5     EC 3.6.58
Mitochondrial Rho GTPase 12     

External Ids:    HGNC: 211681   Entrez Gene: 552882   Ensembl: ENSG000001268587   OMIM: 6138885   UniProtKB: Q8IXI23   

Export aliases for RHOT1 gene to outside databases

Previous GC identifers: GC17P030616 GC17P027493 GC17P026657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RHOT1 Gene:
RHOT1 (ras homolog family member T1) is a protein-coding gene. GO annotations related to this gene include GTPase activity and calcium ion binding. An important paralog of this gene is RHOT2.

UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde
transport of mitochondria and their subcellular distribution

Gene Wiki entry for RHOT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RHOT1 gene promoter:
         AhR   SRF   SRF (504 AA)   HTF   FOXD1   FOXO3b   Arnt   SRY   HFH-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRHOT1 promoter sequence
   Search Chromatin IP Primers for RHOT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RHOT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2-q12

RHOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOT1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P030470:  view genomic region     (about GC identifiers)

Start:
30,469,473 bp from pter      End:
30,580,393 bp from pter
Size:
110,921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2 (See protein sequence)
Recommended Name: Mitochondrial Rho GTPase 1  
Size: 618 amino acids; 70784 Da
Subunit: Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between
mitochondria and the trafficking apparatus of the microtubules
Sequence caution: Sequence=AAH41114.1; Type=Erroneous initiation; Sequence=AAH68463.1; Type=Erroneous initiation;
Sequence=BAA91969.1; Type=Erroneous initiation; Sequence=BAB14185.1; Type=Erroneous initiation;
Secondary accessions: A4FVB6 A6NFV0 B4DG48 J9JIH9 Q6NUR3 Q6P9F8 Q6PJG1 Q6YMW8 Q86UB0 Q8IW28
Q8IXJ7 Q9H067 Q9H9N8 Q9NUZ2
Alternative splicing: 7 isoforms:  Q8IXI2-1   Q8IXI2-2   Q8IXI2-3   Q8IXI2-4   Q8IXI2-5   Q8IXI2-6   Q8IXI2-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RHOT1: NX_Q8IXI2

Explore proteomics data for RHOT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys153, Lys187, Lys194
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RHOT1 (Q8IXI2) (see all 26)
     ILPIMNQ  CTTELNH  DFCRKHK  GWITYQG 


    See RHOT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001028738.1  NP_001028739.2  NP_001028740.1  NP_001275683.1  NP_001275684.1  NP_001275687.1  NP_060777.3  

    ENSEMBL proteins: 
     ENSP00000334724   ENSP00000351132   ENSP00000462698   ENSP00000439737   ENSP00000346215  
     ENSP00000464094   ENSP00000462669   ENSP00000462612   ENSP00000378184   ENSP00000464851  
     ENSP00000463532   ENSP00000467272   ENSP00000464674   ENSP00000461992  
    Reactome Protein details: Q8IXI2

    RHOT1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RHOT1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RHOT1
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    Novus Biologicals RHOT1 Proteins
    Novus Biologicals RHOT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RHOT1

     
    Search eBioscience for Proteins for RHOT1 

     
    antibodies-online proteins for RHOT1 (4 products) 

     
    antibodies-online peptides for RHOT1

    RHOT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for RHOT1
    Cloud-Clone Corp. Antibodies for RHOT1
    Search ThermoFisher Antibodies for RHOT1
    antibodies-online antibodies for RHOT1 (28 products) 

    RHOT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RHOT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RHOT1
    Cloud-Clone Corp. CLIAs for RHOT1
    Search eBioscience for ELISAs for RHOT1 
    antibodies-online kits for RHOT1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    Selected InterPro protein domains (see all 11):
     IPR011992 EF-hand-dom_pair
     IPR013566 EF_hand_assoc_1
     IPR002048 EF_hand_dom
     IPR013684 MIRO-like
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8IXI2

    ProtoNet protein and cluster: Q8IXI2

    4 Blocks protein domains:
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase
    IPB013567 EF hand associated
    IPB013684 Miro-like


    UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
    Similarity: Belongs to the mitochondrial Rho GTPase family
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 2 Miro domains


    Find genes that share domains with RHOT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIRO1_HUMAN, Q8IXI2
    Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde
    transport of mitochondria and their subcellular distribution

         Enzyme Numbers (IUBMB): EC 3.6.52 EC 3.6.5.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003924GTPase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16630562
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RHOT1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rhot1):
     mortality/aging 

    Find genes that share phenotypes with RHOT1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RHOT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RHOT1:
    hsa-mir-16-5p (MIRT000899), hsa-mir-15a-5p (MIRT000900), hsa-mir-335-5p (MIRT018247), hsa-mir-877-3p (MIRT036811)

    Block miRNA regulation of human, mouse, rat RHOT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOT1 (see all 32):
    hsa-miR-623 hsa-miR-142-5p hsa-miR-548j hsa-miR-3938 hsa-miR-429 hsa-miR-520d-5p hsa-miR-548i hsa-miR-509-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RHOT1
    Predesigned siRNA for gene silencing in human, mouse, rat RHOT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RHOT1

    Clone
    Products:
         
    OriGene clones in human, mouse for RHOT1 (see all 17)
    OriGene ORF clones in mouse, rat for RHOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RHOT1 (NM_018307)
    Sino Biological Human cDNA Clone for RHOT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOT1
    Addgene plasmids for RHOT1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RHOT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RHOT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIRO1_HUMAN, Q8IXI2: Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with
    MGARP and RHOT2 at the mitochondria
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    plasma membrane4
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with RHOT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RHOT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58


    Find genes that share SuperPaths with RHOT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for RHOT1
        Rho GTPase cycle


        Pathway & Disease-focused RT2 Profiler PCR Array including RHOT1: 
              Mitochondria in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RHOT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RHOT1 (Q8IXI21, 3 ENSP000003511324) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAK1Q9UPV91, 3, ENSP000003289984EBI-1396430,EBI-1105048 I2D: score=5 STRING: ENSP00000328998
    KIF5CO602821, 3, ENSP000003933794EBI-1396430,EBI-717170 I2D: score=1 STRING: ENSP00000393379
    AMFRQ9UKV53, ENSP000002906494I2D: score=1 STRING: ENSP00000290649
    ATP5A1P257053, ENSP000002820504I2D: score=1 STRING: ENSP00000282050
    CAPZA2P477553, ENSP000003549474I2D: score=1 STRING: ENSP00000354947
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0015031protein transport ----
    GO:0019725cellular homeostasis IMP12482879

    Find genes that share ontologies with RHOT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RHOT1 (MIRO1)

    1 HMDB Compound for RHOT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RHOT1 gene (7 alternative transcripts): 
    NM_001033566.2  NM_001033567.2  NM_001033568.2  NM_001288754.1  NM_001288755.1  NM_001288758.1  NM_018307.4  

    Unigene Cluster for RHOT1:

    Ras homolog family member T1
    Hs.655325  [show with all ESTs]
    Unigene Representative Sequence: NM_001033568
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333942(uc002hgz.3 uc002hhb.3) ENST00000358365(uc002hgw.3 uc002hgy.3 uc010csv.3 uc010wby.2)
    ENST00000583994(uc002hha.3 uc002hgx.3) ENST00000545287 ENST00000354266
    ENST00000581031 ENST00000581094(uc002hgv.3) ENST00000578205 ENST00000580976
    ENST00000394692 ENST00000582602 ENST00000581567 ENST00000580392 ENST00000581148
    ENST00000584692 ENST00000584852 ENST00000582586
    miRNA
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    Block miRNA regulation of human, mouse, rat RHOT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RHOT1 (see all 32):
    hsa-miR-623 hsa-miR-142-5p hsa-miR-548j hsa-miR-3938 hsa-miR-429 hsa-miR-520d-5p hsa-miR-548i hsa-miR-509-5p
    SwitchGear 3'UTR luciferase reporter plasmidRHOT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RHOT1
    Predesigned siRNA for gene silencing in human, mouse, rat RHOT1
    Clone
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    OriGene clones in human, mouse for RHOT1 (see all 17)
    OriGene ORF clones in mouse, rat for RHOT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RHOT1 (NM_018307)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RHOT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RHOT1
    Addgene plasmids for RHOT1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RHOT1
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOT1
      QuantiTect SYBR Green Assays in human, mouse, rat RHOT1
      QuantiFast Probe-based Assays in human, mouse, rat RHOT1

    Additional mRNA sequence: 

    AJ496730.1 AJ517412.1 AK001902.1 AK022695.1 AK294407.1 AL117543.1 AL136929.1 AY094972.1 
    BC015698.2 BC029029.1 BC041114.1 BC051818.1 BC060781.1 BC092401.1 BC110895.1 BC125104.1 
    BC125105.1 

    20 DOTS entries:

    DT.87016523  DT.100777598  DT.92439129  DT.100777602  DT.97795281  DT.100777603  DT.100686976  DT.100777600 
    DT.111227  DT.120955652  DT.95169554  DT.92439132  DT.100035483  DT.120955513  DT.92439135  DT.95169551 
    DT.95359655  DT.99978228  DT.40209185  DT.97845014 

    Selected AceView cDNA sequences (see all 245):

    AA011444 F04328 BF111930 BG776113 Z44339 BG575589 AI436247 BP339916 
    AA682515 AI199847 Z39539 BC060781 AJ496730 BM661631 AI668804 AK001902 
    AA707923 AK129628 BU689545 NM_018307 AA844253 BG612402 CA418104 AA453078 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RHOT1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
    SP1:                                                                                                                                -                           
    SP2:                                                                                                                                -                 -     -   
    SP3:                                                                                                                                -                 -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                -                 -         

    ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e
    SP1:                                    
    SP2:  -                                 
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RHOT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RHOT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAACCTAT
    RHOT1 Expression
    About this image


    RHOT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RHOT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RHOT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655325

    UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
    Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including RHOT1: 
              Mitochondria in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RHOT1
    OriGene qSTAR qPCR primer pairs in human, mouse for RHOT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RHOT1
    QuantiTect SYBR Green Assays in human, mouse, rat RHOT1
    QuantiFast Probe-based Assays in human, mouse, rat RHOT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RHOT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RHOT1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rhot11 , 5 ras homolog gene family, member T11, 5 92.72(n)1
    98.03(a)1
      11 (47.62 cM)5
    590401  NM_001163355.11  NP_001156827.11 
     802090195 
    chicken
    (Gallus gallus)
    Aves RHOT11 ras homolog family member T1 84.74(n)
    94.01(a)
      417410  NM_001006208.1  NP_001006208.1 
    lizard
    (Anolis carolinensis)
    Reptilia RHOT16
    ras homolog family member T1
    93(a)
    1 ↔ 1
    GL343198.1(1580161-1622766)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004922511 mitochondrial Rho GTPase 1-like 74.7(n)
    85.76(a)
      100492251  XM_004918401.1  XP_004918458.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.66392 Danio rerio mRNA similar to RIKEN cDNA 2210403N23 gene (cDNA clone MGC55581 IMAGE2643358), complete cds less 76.79(n)    BC044431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Miro1 Mitochondrial Rho 56.08(n)
    55.73(a)
      42845  NM_170111.2  NP_732936.1 
    worm
    (Caenorhabditis elegans)
    Secernentea miro-11 miro-1 51.85(n)
    45.85(a)
      177238  NM_068219.3  NP_500620.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GEM1(YAL048C)4 Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death less   --   1(54789-52801) 851249  NP_009351.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MIRO21 MIRO2 48.94(n)
    41.7(a)
      825490  NM_116180.3  NP_567139.1 


    ENSEMBL Gene Tree for RHOT1 (if available)
    TreeFam Gene Tree for RHOT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RHOT1 gene
    RHOT22  
    1 SIMAP similar gene for RHOT1 using alignment to 9 protein entries:     MIRO1_HUMAN (see all proteins):
    RHOT2

    Find genes that share paralogs with RHOT1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for RHOT1
    PGOHUM00000248294 PGOHUM00000235011 PGOHUM00000239031


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RHOT1 (see all 1501)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs346731871,2
    C,F--30467516(+) TTTTTT/-ATCTA 3 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs1167569861,2
    C,F--30467562(+) AGCTCT/CGTCAG 3 -- us2k11Minor allele frequency- C:0.06WA 118
    rs129426241,2
    H--30467695(+) GAGATG/TAAAGC 3 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1856977451,2
    --30467790(+) TAACAC/TGGACA 3 -- us2k10--------
    rs739897061,2
    C,F--30467802(+) GGATAG/AAGTTG 3 -- us2k13Minor allele frequency- A:0.50WA CSA 6
    rs1381796971,2
    C--30467913(+) GTGGAA/TTAGGC 3 -- us2k10--------
    rs1427697641,2
    C--30468024(+) AACCCC/TGTCTC 3 -- us2k10--------
    rs1820233951,2
    --30468215(+) AAAACA/CAAACC 3 -- us2k10--------
    rs1460806261,2
    C--30468224(+) CCAAAA/CCAAAA 3 -- us2k10--------
    rs72088381,2
    C,F,A,H--30468566(+) GTTGGT/CATTAC 3 -- us2k119Minor allele frequency- C:0.29NS EA NA WA 2338

    HapMap Linkage Disequilibrium report for RHOT1 (30469473 - 30580393 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RHOT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669243CNV Deletion23128226
    nsv908067CNV Gain21882294
    nsv908068CNV Gain21882294
    dgv944e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RHOT1
    DNA2.0 Custom Variant and Variant Library Synthesis for RHOT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613888    OMIM disorders: --


    Find genes that share disorders with RHOT1           About GenesLikeMe

    Genetic Association Database (GAD): RHOT1
    Human Genome Epidemiology (HuGE) Navigator: RHOT1 (2 documents)

    Export disorders for RHOT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RHOT1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with RHOT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PubMed id 12482879)1, 2, 3 Fransson A.... Aspenstroem P. (J. Biol. Chem. 2003)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. (PubMed id 19528298)1, 2 Li Y.... Rempe D.A. (J. Cell Biol. 2009)
    5. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PubMed id 16630562)1, 2 Fransson S.... Aspenstroem P. (Biochem. Biophys. Res. Commun. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Rho GTPases have diverse effects on the organization of the actin filament system. (PubMed id 14521508)1, 2 Aspenstroem P.... Saras J. (Biochem. J. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55288 HGNC: 21168 AceView: RHOT1 Ensembl:ENSG00000126858 euGenes: HUgn55288
    ECgene: RHOT1 H-InvDB: RHOT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RHOT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RHOT1 gene:
    Search GeneIP for patents involving RHOT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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