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RHOT1 Gene

protein-coding GIFtS: 54

GC17P027493

ras homolog gene family, member T1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ARHT1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARHT1 ^², ³
EC 3.6.5.- ^³
FLJ11040 ^¹, ²
FLJ12633 ^²
MIRO-1 ^¹, ², ³
hMiro-1 ^³

Descriptions
Rac-GTP-binding protein-like protein ^³
Ras homolog gene family member T1 ^³
mitochondrial Rho 1 ^²
rac-GTP binding protein-like protein ^²
ras homolog gene family, member T1 ^²

External Ids
HGNC: 21168¹
Entrez Gene: 55288²
UniProtKB: Q8IXI2³
Ensembl: ENSG00000126858⁷

Search outside databases for aliases for RHOT1 gene

Previous GC identifer: GC17P030616

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2

Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control

of anterograde transport of mitochondria and their subcellular distribution

Gene Wiki entry for RHOT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RHOT1 gene

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2-q12

RHOT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P027493: (about GC identifiers)

Start:	27,493,586 bp from pter
End:	27,576,859 bp from pter
Size:	83,274 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010799.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2 (See protein sequence)

Recommended Name: Mitochondrial Rho GTPase 1

Size: 618 amino acids; 70784 Da

Subunit: Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link

between mitochondria and the trafficking apparatus of the microtubules

Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein (Probable)

Secondary accessions: A4FVB6 A6NFV0 B4DG48 Q6NUR3 Q6P9F8 Q6PJG1 Q6YMW8 Q86UB0 Q8IW28 Q8IXJ7 Q9H067

Q9H9N8 Q9NUZ2

Alternative splicing: 6 isoforms: Q8IXI2-1 Q8IXI2-2 Q8IXI2-3 Q8IXI2-4 Q8IXI2-5 Q8IXI2-6

REFSEQ proteins (3 alternative transcripts):

NP_001028738.1 NP_001028740.1 NP_060777.3

ENSEMBL proteins:

ENSP00000334724 ENSP00000378184 ENSP00000346215 ENSP00000351132 ENSP00000367870

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Rhot1)
	Human Recombinant Proteins from Abnova (RHOT1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005741	mitochondrial outer membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for RHOT1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for RHOT1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Rhot1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RHOT1)
	Novus Biologicals Antibodies for RHOT1

Assays for RHOT1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IXI2

ProtoNet protein and cluster: Q8IXI2

4 Blocks protein families:

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

IPB013567 EF hand associated

IPB013684 Miro-like

UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2

Similarity: Belongs to the mitochondrial Rho GTPase family

Similarity: Contains 2 EF-hand domains

Similarity: Contains 2 Miro domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RHOT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHOT1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001033566

Applied Biosystems Silencer® siRNAs for RHOT1

Sigma-Aldrich siRNA for RHOT1

Sigma-Aldrich shRNA for RHOT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001033566
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001033566
untagged cDNA clones in CMV expression vector (see all 5): NM_001033566

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001033568

UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2

Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control

of anterograde transport of mitochondria and their subcellular distribution

Enzyme Number (IUBMB): EC 3.6.5.-

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003674	molecular_function	ND	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	16630562
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/11 Sigma-Aldrich "Your Favorite Gene" Pathways for RHOT1 (Your Favorite Gene powered by Ingenuity) (see all 11 )

IL-8 Signaling
Germ Cell-Sertoli Cell Junction Signaling
Regulation of Actin-based Motility by Rho
Thrombin Signaling
Cholecystokinin/Gastrin-mediated Signaling

GeneDecks RHOT1 for the pathways selected above

About GeneDecksing

5/127 Interacting proteins for RHOT1 (ENSP00000351132³ Q8IXI2¹) via UniProtKB, MINT, and/or STRING (see all 127 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAK1	Q9UPV9¹	STRING (score=.866) EBI-1396430, EBI-1105048
KIF5C	O60282¹	EBI-1396430, EBI-717170
Kif5c Kif5c (xeno)	P56536¹	EBI-1396430, EBI-994504
Trak2 Trak2 (xeno)	Q8R2H7¹	EBI-1396430, EBI-1396483
RHOBTB1	ENSP00000350595³	STRING (score=.977)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IMP	12482879
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0019725	cellular homeostasis	IMP	12482879
GO:0047497	mitochondrion transport along microtubule	IMP	16630562

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for RHOT1

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RHOT1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RHOT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (RHOT1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001033566

Sigma-Aldrich siRNA for RHOT1

Sigma-Aldrich shRNA for RHOT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001033566 NM_001033568 NM_018307

REFSEQ mRNAs for RHOT1 gene (3 alternative transcripts):

NM_001033566.1 NM_001033568.1 NM_018307.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001033566 NM_001033568 NM_018307

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001033566
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001033566
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001033566

Additional cDNA sequence:

AJ496730.1 AJ517412.1 AK001902.1 AK022695.1 AK294407.1 AL117543.1 AL136929.1 AY094972.1

BC015698.2 BC029029.1 BC041114.1 BC051818.1 BC060781.1 BC092401.1 BC110895.1 BC125104.1

BC125105.1

20 DOTS entries:

DT.87016523 DT.100777598 DT.92439129 DT.100777602 DT.97795281 DT.100777603 DT.100686976 DT.100777600

DT.111227 DT.120955652 DT.95169554 DT.92439132 DT.100035483 DT.120955513 DT.40209185 DT.92439135

DT.95169551 DT.95359655 DT.99978228 DT.97845014

24/245 AceView cDNA sequences (see all 245 ):

AK022695 BF111930 AY094972 AI199847 BF589168 AI003641 BM069542 BC015698

AA280974 AI453068 BE220856 F04328 AI073884 AK001902 BC041114 AI436247

F03470 AI052515 BM760793 AJ517412 AL527595 AI364258 AA453078 BM661631

highest scoring ESTs for RHOT1:

AA011443 AA011444 AA199845 AA251094 AA280974 AA452910 AA453078 AA506048 AA682515 AA718935

Unigene Cluster for RHOT1:

Ras homolog gene family, member T1

Hs.655325 [show with all ESTs]

Unigene Representative Sequence: NM_001033568

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RHOT1 (see all 9 )

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15	^	16a	·	16b	^	17	^	18a	·
SP1:																																											-
SP2:																																											-						-		-
SP3:																																											-						-
SP4:
SP5:																																											-						-

ExUns:	18b	^	19a	·	19b	·	19c	·	19d	·	19e
SP1:
SP2:	-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for RHOT1

5 Ensembl transcripts including schematic representations:

ENST00000333942 ENST00000394692 ENST00000354266 ENST00000358365 ENST00000378607

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RHOT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RHOT1

¹ / ² / ³

5 probe-sets matching RHOT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
91428_at²^{, 3}	U95-E	1	1.00	1.00	1.00	1.00	AI949652	0.80	1.00	0.91	1
218323_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018307	0.60	1.00	0.82	1
222148_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF688108	0.80	1.00	0.91	1
218323_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222148_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATAAACCTAT

SOURCE GeneReport for Unigene cluster: Hs.655325
UniProtKB/Swiss-Prot: MIRO1_HUMAN, Q8IXI2
Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RHOT1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RHOT1¹	--	ras homolog gene family, member T1	95.09(n) 98.71(a)	480613 XM_862873.1 XP_867966.1
cow (Bos taurus)	RHOT1¹	--	ras homolog gene family, member T1	94.82(n) 98.87(a)	511257 NM_001046082.1 NP_001039547.1
mouse (Mus musculus)	Rhot1^{1, 5}	11 (47.26 cM)⁵	ras homolog gene family, member T1^{1, 5}	92.29(n)¹ 97.9(a)¹	59040¹ NM_021536.6¹ NP_067511.4¹ AA415293⁵ AF244542⁵ (see all 37)
chicken (Gallus gallus)	RHOT1¹	--	ras homolog gene family, member T1	84.79(n) 94.01(a)	417410 NM_001006208.1 NP_001006208.1
zebrafish (Danio rerio)	Dr.6639²	--	Danio rerio mRNA similar to RIKEN cDNA 2210403N23 gene more	76.79(n)	BC044431.1

About this table Species with no ortholog for RHOT1

ENSEMBL Gene Tree for RHOT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RHOT1 gene

RHOT2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/507 NCBI SNPs in RHOT1 are shown (see all 507 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 121)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7208838^1,2	A,C,F,H	27492679(+)	`GTTGGT/CATTAC`	3	--	ng5¹		4		EU EA WA	420
--	rs16967203^1,2	C,F,H	27576723(+)	`TATATC/TAGGCT`	3	--	ut3¹ ese³		11		NA EU EA WA	980
--	rs8079125^1,2	A,C	27492835(+)	`CACGCA/GTATGT`	3	--	ng5¹		0	--	--	--	--
	rs7207471^1,2	H	27576130(+)	`TTCAGG/ACAAGA`	3	--	ut3¹ ese³		4		EU EA WA	418
	rs12942624^1,2	H	27491808(+)	`GAGATG/TAAAGC`	3	--	ng5¹		4		EU EA WA	418
	rs16967164^1,2	C,F,H	27558083(+)	`GCTGAA/GATCAT`	3	E/E	syn¹		7		NA EU EA WA	562
	rs2036376^1,2	A,C,F,H,O	27558424(-)	`ACAGCC/TGGGAA`	3	--	int¹		12		EA NA EU WA	1048
	rs2044206^1,2	A,C,F,H,O	27552682(+)	`TCTTAT/CGGGAA`	3	--	int¹		7		EU EA WA NA	554
	rs8069167^1,2	A,C,F,H	27499544(+)	`TGTTCG/ATACAG`	3	--	int¹		4		EU EA WA	414
	rs9913638^1,2	A,C,F,H	27512054(+)	`ggacaG/Aaggca`	3	--	int¹		4		EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for RHOT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/15 PubMed articles for RHOT1 gene (see all 15 ):

Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PubMed id 12482879)^{2, 3, 4} Fransson A.... Aspenstroem P. (2003)
The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PubMed id 16630562)^{3, 4} Fransson S.... Aspenstroem P. (2006)
Rho GTPases have diverse effects on the organization of the actin filament system. (PubMed id 14521508)^{3, 4} Aspenstroem P.... Saras J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{3, 4} Wiemann S.... Poustka A. (2001)
GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. (PubMed id 19103291)³ MacAskill A.F....Kittler J.T. (2009)
Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase. (PubMed id 19098100)³ Saotome M....HajnA^czky G. (2008)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)⁴ Zody M.C.... Nusbaum C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 55288	HGNC: 21168	AceView: RHOT1	Ensembl:ENSG00000126858	euGenes: HUgn55288
ECgene: RHOT1	H-InvDB: RHOT1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for RHOT1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for RHOT1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RHOT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RHOT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RHOT1		Antibodies for RHOT1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RHOT1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RHOT1)
	Antibodies (RHOT1)
	Chimera RNAi (RHOT1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Rhot1)
	Antibodies (Rhot1)

Search OriGene for RHOT1

Search Tocris compounds for RHOT1

	Drugs for RHOT1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RHOT1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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RHOT1 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for RHOT1

Summaries
for RHOT1

Genomic Location
for RHOT1

Proteins
for RHOT1

Protein Domains/
Families
for RHOT1

Gene Function
for RHOT1

Pathways & Interactions
for RHOT1

Drugs & Compounds
for RHOT1

Transcripts
for RHOT1

Expression
for RHOT1

Orthologs
for RHOT1

Paralogs
for RHOT1

SNPs/Variants
for RHOT1

Disorders & Mutations
for RHOT1

Medical News
for RHOT1

Publications
for RHOT1

Search for RHOT1

Genome Databases showing RHOT1

Other Databases showing RHOT1

Specialized Databases showing RHOT1

Licensable Technologies
for RHOT1

Services
for RHOT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RHOT1 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor RHOT1

Summariesfor RHOT1

Genomic Locationfor RHOT1

Proteinsfor RHOT1

Protein Domains/Familiesfor RHOT1

Gene Functionfor RHOT1

Pathways & Interactionsfor RHOT1

Drugs & Compoundsfor RHOT1

Transcriptsfor RHOT1

Expression for RHOT1

Orthologsfor RHOT1

Paralogsfor RHOT1

SNPs/Variantsfor RHOT1

Disorders & Mutationsfor RHOT1

Medical Newsfor RHOT1

Publicationsfor RHOT1

Search for RHOT1

Genome Databases showing RHOT1

Other Databases showing RHOT1

Specialized Databases showing RHOT1

Licensable Technologiesfor RHOT1

Servicesfor RHOT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RHOT1

Summaries
for RHOT1

Genomic Location
for RHOT1

Proteins
for RHOT1

Protein Domains/
Families
for RHOT1

Gene Function
for RHOT1

Pathways & Interactions
for RHOT1

Drugs & Compounds
for RHOT1

Transcripts
for RHOT1

Expression
for RHOT1

Orthologs
for RHOT1

Paralogs
for RHOT1

SNPs/Variants
for RHOT1

Disorders & Mutations
for RHOT1

Medical News
for RHOT1

Publications
for RHOT1

Licensable Technologies
for RHOT1

Services
for RHOT1