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Aliases for RHOT1 Gene

Aliases for RHOT1 Gene

  • Ras Homolog Family Member T1 2 3 5
  • Ras Homolog Gene Family, Member T1 2 3
  • Mitochondrial Rho (MIRO) GTPase 1 2 3
  • MIRO-1 3 4
  • ARHT1 3 4
  • Rac-GTP Binding Protein-Like Protein 3
  • Rac-GTP-Binding Protein-Like Protein 4
  • Ras Homolog Gene Family Member T1 4
  • EC 3.6.5.- 4
  • EC 3.6.5 63
  • HMiro-1 4
  • MIRO1 3

External Ids for RHOT1 Gene

Previous HGNC Symbols for RHOT1 Gene

  • ARHT1

Previous GeneCards Identifiers for RHOT1 Gene

  • GC17P030616
  • GC17P027493
  • GC17P030470
  • GC17P026657

Summaries for RHOT1 Gene

GeneCards Summary for RHOT1 Gene

RHOT1 (Ras Homolog Family Member T1) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT2.

UniProtKB/Swiss-Prot for RHOT1 Gene

  • Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Gene Wiki entry for RHOT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOT1 Gene

Genomics for RHOT1 Gene

Regulatory Elements for RHOT1 Gene

Enhancers for RHOT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RHOT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOT1 Gene

32,142,454 bp from pter
32,253,374 bp from pter
110,921 bases
Plus strand

Genomic View for RHOT1 Gene

Genes around RHOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOT1 Gene

Proteins for RHOT1 Gene

  • Protein details for RHOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial Rho GTPase 1
    Protein Accession:
    Secondary Accessions:
    • A4FVB6
    • A6NFV0
    • B4DG48
    • J9JIH9
    • Q6NUR3
    • Q6P9F8
    • Q6PJG1
    • Q6YMW8
    • Q86UB0
    • Q8IW28
    • Q8IXJ7
    • Q9H067
    • Q9H9N8
    • Q9NUZ2

    Protein attributes for RHOT1 Gene

    618 amino acids
    Molecular mass:
    70784 Da
    Quaternary structure:
    • Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules.
    • Sequence=AAH41114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH68463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14185.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOT1 Gene

neXtProt entry for RHOT1 Gene

Proteomics data for RHOT1 Gene at MOPED

Post-translational modifications for RHOT1 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 153, Lys 187, and Lys 194
  • Modification sites at PhosphoSitePlus

Domains & Families for RHOT1 Gene

Suggested Antigen Peptide Sequences for RHOT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the mitochondrial Rho GTPase family.
  • Contains 2 EF-hand domains.
  • Contains 2 Miro domains.
  • Belongs to the mitochondrial Rho GTPase family.
genes like me logo Genes that share domains with RHOT1: view

Function for RHOT1 Gene

Molecular function for RHOT1 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Enzyme Numbers (IUBMB) for RHOT1 Gene

Gene Ontology (GO) - Molecular Function for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16630562
genes like me logo Genes that share ontologies with RHOT1: view
genes like me logo Genes that share phenotypes with RHOT1: view

Animal Models for RHOT1 Gene

MGI Knock Outs for RHOT1:

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOT1 Gene

Localization for RHOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOT1 Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Subcellular locations from

Jensen Localization Image for RHOT1 Gene COMPARTMENTS Subcellular localization image for RHOT1 gene
Compartment Confidence
cytosol 5
mitochondrion 5
plasma membrane 4
nucleus 2
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,NAS 22078885
GO:0005829 cytosol TAS --
GO:0016021 integral component of membrane IEA --
GO:0031307 integral component of mitochondrial outer membrane IEA,IDA 12482879
genes like me logo Genes that share ontologies with RHOT1: view

Pathways & Interactions for RHOT1 Gene

genes like me logo Genes that share pathways with RHOT1: view

Pathways by source for RHOT1 Gene

Gene Ontology (GO) - Biological Process for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0047497 mitochondrion transport along microtubule IMP 16630562
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOT1: view

No data available for SIGNOR curated interactions for RHOT1 Gene

Drugs & Compounds for RHOT1 Gene

(1) Drugs for RHOT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHOT1: view

Transcripts for RHOT1 Gene

Unigene Clusters for RHOT1 Gene

Ras homolog family member T1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
SP1: -
SP2: - - -
SP3: - -
SP5: - -
SP6: - -
SP7: - -
SP8: -

ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e
SP2: -
SP7: -
SP8: -

Relevant External Links for RHOT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOT1 Gene

mRNA expression in normal human tissues for RHOT1 Gene

Protein differential expression in normal tissues from HIPED for RHOT1 Gene

This gene is overexpressed in Frontal cortex (7.8) and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOT1 Gene

SOURCE GeneReport for Unigene cluster for RHOT1 Gene Hs.655325

mRNA Expression by UniProt/SwissProt for RHOT1 Gene

Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with RHOT1: view

Protein tissue co-expression partners for RHOT1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RHOT1 Gene

Orthologs for RHOT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RHOT1 35
  • 94.77 (n)
  • 98.87 (a)
RHOT1 36
  • 97 (a)
(Canis familiaris)
Mammalia RHOT1 35
  • 95.4 (n)
  • 98.79 (a)
RHOT1 36
  • 99 (a)
(Mus musculus)
Mammalia Rhot1 35
  • 92.72 (n)
  • 98.03 (a)
Rhot1 16
Rhot1 36
  • 96 (a)
(Pan troglodytes)
Mammalia RHOT1 35
  • 99.43 (n)
  • 99.85 (a)
RHOT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rhot1 35
  • 92.18 (n)
  • 97.57 (a)
(Monodelphis domestica)
Mammalia RHOT1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia RHOT1 36
  • 94 (a)
(Gallus gallus)
Aves RHOT1 35
  • 84.74 (n)
  • 94.01 (a)
RHOT1 36
  • 94 (a)
(Anolis carolinensis)
Reptilia RHOT1 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492251 35
  • 74.7 (n)
  • 85.76 (a)
(Danio rerio)
Actinopterygii Dr.6639 35
rhot1a 35
  • 74.49 (n)
  • 86.08 (a)
RHOT1 (3 of 3) 36
  • 85 (a)
rhot1a 36
  • 86 (a)
rhot1b 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007998 35
  • 55.57 (n)
  • 56.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Miro 35
  • 56.08 (n)
  • 55.73 (a)
Miro 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea miro-1 35
  • 51.85 (n)
  • 45.85 (a)
miro-1 36
  • 44 (a)
miro-2 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEM1 36
  • 30 (a)
GEM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MIRO2 35
  • 48.94 (n)
  • 41.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for RHOT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOT1 Gene

Gene Tree for RHOT1 (if available)
Gene Tree for RHOT1 (if available)

Paralogs for RHOT1 Gene

Paralogs for RHOT1 Gene

(1) SIMAP similar genes for RHOT1 Gene using alignment to 9 proteins: Pseudogenes for RHOT1 Gene

genes like me logo Genes that share paralogs with RHOT1: view

Variants for RHOT1 Gene

Sequence variations from dbSNP and Humsavar for RHOT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs172523 -- 32,206,107(-) AAGGA(A/G)ACGGG intron-variant
rs184201 -- 32,214,895(-) aaaaa(A/G)GACAA intron-variant
rs188534 -- 32,206,435(-) AAAGT(A/T)TAGAC intron-variant
rs650738 -- 32,199,224(+) AATTT(A/C)TAATA intron-variant
rs660864 -- 32,196,450(-) cttta(C/G)gaggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOT1 Gene

Variant ID Type Subtype PubMed ID
dgv944e1 CNV Complex 17122850
nsv908067 CNV Gain 21882294
esv2669243 CNV Deletion 23128226
nsv908068 CNV Gain 21882294

Variation tolerance for RHOT1 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RHOT1 Gene

Disorders for RHOT1 Gene

Relevant External Links for RHOT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RHOT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOT1 Gene

Publications for RHOT1 Gene

  1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PMID: 12482879) Fransson A. … Aspenstroem P. (J. Biol. Chem. 2003) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis. (PMID: 26254304) Kumar A. … Walden H. (EMBO J. 2015) 3
  5. DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking. (PMID: 24092329) Ogawa F. … Millar J.K. (Hum. Mol. Genet. 2014) 3

Products for RHOT1 Gene

Sources for RHOT1 Gene