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Aliases for RHOT1 Gene

Aliases for RHOT1 Gene

  • Ras Homolog Family Member T1 2 3 5
  • Ras Homolog Gene Family, Member T1 2 3
  • Mitochondrial Rho (MIRO) GTPase 1 2 3
  • MIRO-1 3 4
  • ARHT1 3 4
  • Rac-GTP Binding Protein-Like Protein 3
  • Rac-GTP-Binding Protein-Like Protein 4
  • Ras Homolog Gene Family Member T1 4
  • Mitochondrial Rho GTPase 1 3
  • EC 3.6.5.- 4
  • EC 3.6.5 61
  • HMiro-1 4
  • MIRO1 3

External Ids for RHOT1 Gene

Previous HGNC Symbols for RHOT1 Gene

  • ARHT1

Previous GeneCards Identifiers for RHOT1 Gene

  • GC17P030616
  • GC17P027493
  • GC17P030470
  • GC17P026657

Summaries for RHOT1 Gene

GeneCards Summary for RHOT1 Gene

RHOT1 (Ras Homolog Family Member T1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT2.

UniProtKB/Swiss-Prot for RHOT1 Gene

  • Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Gene Wiki entry for RHOT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOT1 Gene

Genomics for RHOT1 Gene

Regulatory Elements for RHOT1 Gene

Enhancers for RHOT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RHOT1 on UCSC Golden Path with GeneCards custom track

Promoters for RHOT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHOT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOT1 Gene

Chromosome:
17
Start:
32,142,454 bp from pter
End:
32,253,374 bp from pter
Size:
110,921 bases
Orientation:
Plus strand

Genomic View for RHOT1 Gene

Genes around RHOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOT1 Gene

Proteins for RHOT1 Gene

  • Protein details for RHOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXI2-MIRO1_HUMAN
    Recommended name:
    Mitochondrial Rho GTPase 1
    Protein Accession:
    Q8IXI2
    Secondary Accessions:
    • A4FVB6
    • A6NFV0
    • B4DG48
    • J9JIH9
    • Q6NUR3
    • Q6P9F8
    • Q6PJG1
    • Q6YMW8
    • Q86UB0
    • Q8IW28
    • Q8IXJ7
    • Q9H067
    • Q9H9N8
    • Q9NUZ2

    Protein attributes for RHOT1 Gene

    Size:
    618 amino acids
    Molecular mass:
    70784 Da
    Quaternary structure:
    • Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules.
    SequenceCaution:
    • Sequence=AAH41114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH68463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14185.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RHOT1 Gene

neXtProt entry for RHOT1 Gene

Post-translational modifications for RHOT1 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 153, Lys 187, and Lys 194
  • Modification sites at PhosphoSitePlus

Domains & Families for RHOT1 Gene

Suggested Antigen Peptide Sequences for RHOT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXI2

UniProtKB/Swiss-Prot:

MIRO1_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the mitochondrial Rho GTPase family.
Domain:
  • Contains 2 EF-hand domains.
  • Contains 2 Miro domains.
Family:
  • Belongs to the mitochondrial Rho GTPase family.
genes like me logo Genes that share domains with RHOT1: view

Function for RHOT1 Gene

Molecular function for RHOT1 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Enzyme Numbers (IUBMB) for RHOT1 Gene

Gene Ontology (GO) - Molecular Function for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16630562
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOT1: view
genes like me logo Genes that share phenotypes with RHOT1: view

Animal Models for RHOT1 Gene

MGI Knock Outs for RHOT1:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for RHOT1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOT1 Gene

Localization for RHOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOT1 Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOT1 Gene COMPARTMENTS Subcellular localization image for RHOT1 gene
Compartment Confidence
cytosol 5
mitochondrion 5
plasma membrane 4
nucleus 2
cytoskeleton 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion NAS 22078885
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0031307 integral component of mitochondrial outer membrane IDA 12482879
genes like me logo Genes that share ontologies with RHOT1: view

Pathways & Interactions for RHOT1 Gene

genes like me logo Genes that share pathways with RHOT1: view

Pathways by source for RHOT1 Gene

Gene Ontology (GO) - Biological Process for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0019725 cellular homeostasis IMP 12482879
GO:0047497 mitochondrion transport along microtubule IMP 16630562
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0097345 mitochondrial outer membrane permeabilization IMP 12482879
genes like me logo Genes that share ontologies with RHOT1: view

No data available for SIGNOR curated interactions for RHOT1 Gene

Drugs & Compounds for RHOT1 Gene

(1) Drugs for RHOT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHOT1: view

Transcripts for RHOT1 Gene

Unigene Clusters for RHOT1 Gene

Ras homolog family member T1:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for RHOT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5: - -
SP6: - -
SP7: - -
SP8: -
SP9:

ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:

Relevant External Links for RHOT1 Gene

GeneLoc Exon Structure for
RHOT1
ECgene alternative splicing isoforms for
RHOT1

Expression for RHOT1 Gene

mRNA expression in normal human tissues for RHOT1 Gene

Protein differential expression in normal tissues from HIPED for RHOT1 Gene

This gene is overexpressed in Frontal cortex (7.8) and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RHOT1 Gene



Protein tissue co-expression partners for RHOT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOT1 Gene:

RHOT1

SOURCE GeneReport for Unigene cluster for RHOT1 Gene:

Hs.655325

mRNA Expression by UniProt/SwissProt for RHOT1 Gene:

Q8IXI2-MIRO1_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with RHOT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RHOT1 Gene

Orthologs for RHOT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RHOT1 34
  • 94.77 (n)
  • 98.87 (a)
RHOT1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOT1 34
  • 95.4 (n)
  • 98.79 (a)
RHOT1 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhot1 34
  • 92.72 (n)
  • 98.03 (a)
Rhot1 16
Rhot1 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RHOT1 34
  • 99.43 (n)
  • 99.85 (a)
RHOT1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhot1 34
  • 92.18 (n)
  • 97.57 (a)
oppossum
(Monodelphis domestica)
Mammalia RHOT1 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOT1 35
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOT1 34
  • 84.74 (n)
  • 94.01 (a)
RHOT1 35
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOT1 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492251 34
  • 74.7 (n)
  • 85.76 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.6639 34
rhot1a 34
  • 74.49 (n)
  • 86.08 (a)
RHOT1 (3 of 3) 35
  • 85 (a)
OneToMany
rhot1a 35
  • 86 (a)
OneToMany
rhot1b 35
  • 79 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007998 34
  • 55.57 (n)
  • 56.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Miro 34
  • 56.08 (n)
  • 55.73 (a)
Miro 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea miro-1 34
  • 51.85 (n)
  • 45.85 (a)
miro-1 35
  • 44 (a)
ManyToMany
miro-2 35
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEM1 35
  • 30 (a)
OneToMany
GEM1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons MIRO2 34
  • 48.94 (n)
  • 41.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
Species where no ortholog for RHOT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOT1 Gene

ENSEMBL:
Gene Tree for RHOT1 (if available)
TreeFam:
Gene Tree for RHOT1 (if available)

Paralogs for RHOT1 Gene

Paralogs for RHOT1 Gene

(1) SIMAP similar genes for RHOT1 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for RHOT1 Gene

genes like me logo Genes that share paralogs with RHOT1: view

Variants for RHOT1 Gene

Sequence variations from dbSNP and Humsavar for RHOT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs172523 -- 32,206,107(-) AAGGA(A/G)ACGGG intron-variant
rs184201 -- 32,214,895(-) aaaaa(A/G)GACAA intron-variant
rs188534 -- 32,206,435(-) AAAGT(A/T)TAGAC intron-variant
rs650738 -- 32,199,224(+) AATTT(A/C)TAATA intron-variant
rs660864 -- 32,196,450(-) cttta(C/G)gaggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOT1 Gene

Variant ID Type Subtype PubMed ID
esv2669243 CNV deletion 23128226
esv2758684 CNV gain 17122850
esv3640377 CNV gain 21293372
esv3640378 CNV loss 21293372
esv3640379 CNV gain 21293372
nsv1057055 CNV gain 25217958
nsv1066680 CNV gain 25217958
nsv574692 CNV gain 21841781
nsv574693 CNV gain 21841781
nsv978412 CNV duplication 23825009

Variation tolerance for RHOT1 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RHOT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOT1 Gene

Disorders for RHOT1 Gene

Relevant External Links for RHOT1

Genetic Association Database (GAD)
RHOT1
Human Genome Epidemiology (HuGE) Navigator
RHOT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOT1

No disorders were found for RHOT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOT1 Gene

Publications for RHOT1 Gene

  1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PMID: 12482879) Fransson A. … Aspenstroem P. (J. Biol. Chem. 2003) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  4. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. (PMID: 19528298) Li Y. … Rempe D.A. (J. Cell Biol. 2009) 3 4 65
  5. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S. … Aspenstroem P. (Biochem. Biophys. Res. Commun. 2006) 3 4 65

Products for RHOT1 Gene

Sources for RHOT1 Gene

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