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Aliases for RHOT1 Gene

Aliases for RHOT1 Gene

  • Ras Homolog Family Member T1 2 3 5
  • Ras Homolog Gene Family, Member T1 2 3
  • Mitochondrial Rho (MIRO) GTPase 1 2 3
  • MIRO-1 3 4
  • ARHT1 3 4
  • Rac-GTP Binding Protein-Like Protein 3
  • Rac-GTP-Binding Protein-Like Protein 4
  • Ras Homolog Gene Family Member T1 4
  • Mitochondrial Rho GTPase 1 3
  • EC 3.6.5.- 4
  • EC 3.6.5 61
  • HMiro-1 4
  • MIRO1 3

External Ids for RHOT1 Gene

Previous HGNC Symbols for RHOT1 Gene

  • ARHT1

Previous GeneCards Identifiers for RHOT1 Gene

  • GC17P030616
  • GC17P027493
  • GC17P030470
  • GC17P026657

Summaries for RHOT1 Gene

GeneCards Summary for RHOT1 Gene

RHOT1 (Ras Homolog Family Member T1) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Signaling by GPCR. GO annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RHOT2.

UniProtKB/Swiss-Prot for RHOT1 Gene

  • Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Gene Wiki entry for RHOT1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOT1 Gene

Genomics for RHOT1 Gene

Regulatory Elements for RHOT1 Gene

Enhancers for RHOT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F032015 1.2 Ensembl ENCODE 11.7 -126.5 -126497 1.3 PKNOX1 FEZF1 ZNF2 GLIS2 KLF7 ZNF263 SP3 YY2 TSHZ1 ZNF488 LOC105371730 RHOT1 COPRS GC17M032014 PIR62613
GH17F032150 1.4 Ensembl ENCODE 9.2 +9.4 9426 3.0 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 CBX5 TMEM98 COPRS RHOT1 EVI2A ARGFXP2 PIR59000
GH17F032006 1.1 ENCODE 11.7 -134.6 -134575 2.6 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 ZNF263 SP3 SP5 COPRS LOC105371730 RHOT1 LRRC37B PIR62613
GH17F032140 1.1 ENCODE 11 -0.1 -79 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS UTP6 SUZ12 RHOT1 ENSG00000277511
GH17F032138 1.1 Ensembl ENCODE 10.8 -3.4 -3354 0.6 ELF3 PKNOX1 ARID4B ZNF2 RAD21 RARA GTF3C2 ZNF366 ZNF143 MIXL1 UTP6 SUZ12 RHOT1 RHBDL3 COPRS ENSG00000277511
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RHOT1 on UCSC Golden Path with GeneCards custom track

Promoters for RHOT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001344220 46 3001 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 ZNF263

Genomic Location for RHOT1 Gene

32,142,454 bp from pter
32,253,374 bp from pter
110,921 bases
Plus strand

Genomic View for RHOT1 Gene

Genes around RHOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOT1 Gene

Proteins for RHOT1 Gene

  • Protein details for RHOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitochondrial Rho GTPase 1
    Protein Accession:
    Secondary Accessions:
    • A4FVB6
    • A6NFV0
    • B4DG48
    • J9JIH9
    • Q6NUR3
    • Q6P9F8
    • Q6PJG1
    • Q6YMW8
    • Q86UB0
    • Q8IW28
    • Q8IXJ7
    • Q9H067
    • Q9H9N8
    • Q9NUZ2

    Protein attributes for RHOT1 Gene

    618 amino acids
    Molecular mass:
    70784 Da
    Quaternary structure:
    • Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules.
    • Sequence=AAH41114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH68463.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14185.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RHOT1 Gene

    Alternative splice isoforms for RHOT1 Gene

neXtProt entry for RHOT1 Gene

Selected DME Specific Peptides for RHOT1 Gene


Post-translational modifications for RHOT1 Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Ubiquitination at Lys 153, Lys 187, and Lys 194
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for RHOT1 Gene

Suggested Antigen Peptide Sequences for RHOT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EF-hand domains.
  • Belongs to the mitochondrial Rho GTPase family.
  • Contains 2 EF-hand domains.
  • Contains 2 Miro domains.
  • Belongs to the mitochondrial Rho GTPase family.
genes like me logo Genes that share domains with RHOT1: view

Function for RHOT1 Gene

Molecular function for RHOT1 Gene

UniProtKB/Swiss-Prot Function:
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.

Enzyme Numbers (IUBMB) for RHOT1 Gene

Gene Ontology (GO) - Molecular Function for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16630562
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RHOT1: view
genes like me logo Genes that share phenotypes with RHOT1: view

Animal Models for RHOT1 Gene

MGI Knock Outs for RHOT1:

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RHOT1 Gene

Localization for RHOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOT1 Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RHOT1 gene
Compartment Confidence
mitochondrion 5
cytosol 5
plasma membrane 4
nucleus 2
extracellular 1
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion NAS 22078885
GO:0005741 mitochondrial outer membrane IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RHOT1: view

Pathways & Interactions for RHOT1 Gene

genes like me logo Genes that share pathways with RHOT1: view

Pathways by source for RHOT1 Gene

Gene Ontology (GO) - Biological Process for RHOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007005 mitochondrion organization IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0019725 cellular homeostasis IMP 12482879
GO:0047497 mitochondrion transport along microtubule IMP 16630562
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RHOT1: view

No data available for SIGNOR curated interactions for RHOT1 Gene

Drugs & Compounds for RHOT1 Gene

(1) Drugs for RHOT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RHOT1: view

Transcripts for RHOT1 Gene

Unigene Clusters for RHOT1 Gene

Ras homolog family member T1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RHOT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17 ^ 18a ·
SP1: -
SP2: - - -
SP3: - -
SP5: - -
SP6: - -
SP7: - -
SP8: -

ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e
SP2: -
SP7: -
SP8: -

Relevant External Links for RHOT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RHOT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RHOT1 Gene

Protein differential expression in normal tissues from HIPED for RHOT1 Gene

This gene is overexpressed in Frontal cortex (7.8) and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RHOT1 Gene

Protein tissue co-expression partners for RHOT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RHOT1 Gene:


SOURCE GeneReport for Unigene cluster for RHOT1 Gene:


mRNA Expression by UniProt/SwissProt for RHOT1 Gene:

Tissue specificity: Ubiquitously expressed. Expressed at high level in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with RHOT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RHOT1 Gene

Orthologs for RHOT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RHOT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RHOT1 34 35
  • 99.43 (n)
(Canis familiaris)
Mammalia RHOT1 34 35
  • 95.4 (n)
(Bos Taurus)
Mammalia RHOT1 34 35
  • 94.77 (n)
(Ornithorhynchus anatinus)
Mammalia RHOT1 35
  • 94 (a)
(Mus musculus)
Mammalia Rhot1 34 16 35
  • 92.72 (n)
(Rattus norvegicus)
Mammalia Rhot1 34
  • 92.18 (n)
(Monodelphis domestica)
Mammalia RHOT1 35
  • 90 (a)
(Gallus gallus)
Aves RHOT1 34 35
  • 84.74 (n)
(Anolis carolinensis)
Reptilia RHOT1 35
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492251 34
  • 74.7 (n)
(Danio rerio)
Actinopterygii RHOT1 (3 of 3) 35
  • 85 (a)
rhot1b 35
  • 79 (a)
rhot1a 34 35
  • 74.49 (n)
Dr.6639 34
fruit fly
(Drosophila melanogaster)
Insecta Miro 34 35
  • 56.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007998 34
  • 55.57 (n)
(Caenorhabditis elegans)
Secernentea miro-1 34 35
  • 51.85 (n)
miro-2 35
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GEM1 35 37
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MIRO2 34
  • 48.94 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
Species where no ortholog for RHOT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RHOT1 Gene

Gene Tree for RHOT1 (if available)
Gene Tree for RHOT1 (if available)

Paralogs for RHOT1 Gene

Paralogs for RHOT1 Gene

(1) SIMAP similar genes for RHOT1 Gene using alignment to 9 proteins: Pseudogenes for RHOT1 Gene

genes like me logo Genes that share paralogs with RHOT1: view

Variants for RHOT1 Gene

Sequence variations from dbSNP and Humsavar for RHOT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1013589 -- 32,205,677(-) gaggc(A/G)tgagc intron-variant
rs1039401 -- 32,208,776(-) TACAG(C/T)ACTTA intron-variant
rs10468586 -- 32,230,263(+) tgttg(A/G)ccagg intron-variant
rs10468587 -- 32,230,312(+) tcggc(C/T)tccca intron-variant
rs1053567 -- 32,227,956(-) ATTTT(A/T)AAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOT1 Gene

Variant ID Type Subtype PubMed ID
nsv978412 CNV duplication 23825009
nsv574693 CNV gain 21841781
nsv574692 CNV gain 21841781
nsv1066680 CNV gain 25217958
nsv1057055 CNV gain 25217958
esv3640379 CNV gain 21293372
esv3640378 CNV loss 21293372
esv3640377 CNV gain 21293372
esv2758684 CNV gain 17122850
esv2669243 CNV deletion 23128226

Variation tolerance for RHOT1 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RHOT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RHOT1 Gene

Disorders for RHOT1 Gene

Relevant External Links for RHOT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RHOT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOT1 Gene

Publications for RHOT1 Gene

  1. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. (PMID: 12482879) Fransson A. … Aspenstroem P. (J. Biol. Chem. 2003) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. (PMID: 19528298) Li Y. … Rempe D.A. (J. Cell Biol. 2009) 3 4 64
  5. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. (PMID: 16630562) Fransson S. … Aspenstroem P. (Biochem. Biophys. Res. Commun. 2006) 3 4 64

Products for RHOT1 Gene

Sources for RHOT1 Gene

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