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Aliases for RHOQ Gene

Aliases for RHOQ Gene

  • Ras Homolog Family Member Q 2 3 5
  • Ras Homolog Gene Family, Member Q 2 3
  • Ras-Like Protein Family Member 7A 3 4
  • RAS-Like, Family 7, Member A 2 3
  • Ras-Like Protein TC10 3 4
  • RASL7A 3 4
  • ARHQ 3 4
  • TC10 3 4
  • Epididymis Secretory Protein Li 42 3
  • HEL-S-42 3
  • TC10A 3

External Ids for RHOQ Gene

Previous HGNC Symbols for RHOQ Gene

  • RASL7A
  • ARHQ

Previous GeneCards Identifiers for RHOQ Gene

  • GC02P046745
  • GC02P046682
  • GC02P046623
  • GC02P046768

Summaries for RHOQ Gene

Entrez Gene Summary for RHOQ Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

GeneCards Summary for RHOQ Gene

RHOQ (Ras Homolog Family Member Q) is a Protein Coding gene. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi and ERK Signaling. GO annotations related to this gene include GTP binding and profilin binding. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOQ Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

Gene Wiki entry for RHOQ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOQ Gene

Genomics for RHOQ Gene

Regulatory Elements for RHOQ Gene

Enhancers for RHOQ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RHOQ on UCSC Golden Path with GeneCards custom track

Promoters for RHOQ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RHOQ on UCSC Golden Path with GeneCards custom track

Genomic Location for RHOQ Gene

Chromosome:
2
Start:
46,541,806 bp from pter
End:
46,584,688 bp from pter
Size:
42,883 bases
Orientation:
Plus strand

Genomic View for RHOQ Gene

Genes around RHOQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RHOQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RHOQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOQ Gene

Proteins for RHOQ Gene

  • Protein details for RHOQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17081-RHOQ_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoQ
    Protein Accession:
    P17081
    Secondary Accessions:
    • D6W5A6
    • Q0VGN1
    • Q52LS8
    • Q53SJ1
    • Q6NS39
    • Q6P146
    • Q7Z480

    Protein attributes for RHOQ Gene

    Size:
    205 amino acids
    Molecular mass:
    22659 Da
    Quaternary structure:
    • Interacts with CDC42EP4 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ). Interacts with EXO70 in a GTP-dependent manner. Interacts with GOPC.
    SequenceCaution:
    • Sequence=AAA36547.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAM21123.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RHOQ Gene

neXtProt entry for RHOQ Gene

Proteomics data for RHOQ Gene at MOPED

Post-translational modifications for RHOQ Gene

  • May be post-translationally modified by both palmitoylation and polyisoprenylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RHOQ Gene

No data available for DME Specific Peptides for RHOQ Gene

Domains & Families for RHOQ Gene

Gene Families for RHOQ Gene

Suggested Antigen Peptide Sequences for RHOQ Gene

Graphical View of Domain Structure for InterPro Entry

P17081

UniProtKB/Swiss-Prot:

RHOQ_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RHOQ: view

Function for RHOQ Gene

Molecular function for RHOQ Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
UniProtKB/Swiss-Prot Function:
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

Gene Ontology (GO) - Molecular Function for RHOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032427 GBD domain binding IPI 10445846
genes like me logo Genes that share ontologies with RHOQ: view
genes like me logo Genes that share phenotypes with RHOQ: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RHOQ Gene

Localization for RHOQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOQ Gene

Cytoplasm. Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOQ Gene COMPARTMENTS Subcellular localization image for RHOQ gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
plasma membrane 5
cytoskeleton 4
nucleus 2

Gene Ontology (GO) - Cellular Components for RHOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030660 Golgi-associated vesicle membrane TAS --
GO:0045121 membrane raft IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with RHOQ: view

Pathways & Interactions for RHOQ Gene

genes like me logo Genes that share pathways with RHOQ: view

SIGNOR curated interactions for RHOQ Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for RHOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008286 insulin receptor signaling pathway IMP 11309621
GO:0030866 cortical actin cytoskeleton organization IEA,IMP 11821390
GO:0032869 cellular response to insulin stimulus IEA,IMP 11309621
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 10445846
genes like me logo Genes that share ontologies with RHOQ: view

Drugs & Compounds for RHOQ Gene

(4) Drugs for RHOQ Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(4) Additional Compounds for RHOQ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RHOQ: view

Transcripts for RHOQ Gene

Unigene Clusters for RHOQ Gene

Ras homolog family member Q:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOQ Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2: -
SP3:

Relevant External Links for RHOQ Gene

GeneLoc Exon Structure for
RHOQ
ECgene alternative splicing isoforms for
RHOQ

Expression for RHOQ Gene

mRNA expression in normal human tissues for RHOQ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOQ Gene

This gene is overexpressed in Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for RHOQ Gene

This gene is overexpressed in Prostate (31.3), Brain (21.6), and Cardia (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOQ Gene



SOURCE GeneReport for Unigene cluster for RHOQ Gene Hs.709193

genes like me logo Genes that share expression patterns with RHOQ: view

Protein tissue co-expression partners for RHOQ Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RHOQ Gene

Orthologs for RHOQ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOQ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RHOQ 35
  • 96.91 (n)
  • 100 (a)
RHOQ 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOQ 35
  • 94.21 (n)
  • 95.81 (a)
RHOQ 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhoq 35
  • 94.15 (n)
  • 99.51 (a)
Rhoq 16
Rhoq 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RHOQ 35
  • 99.51 (n)
  • 99.02 (a)
rat
(Rattus norvegicus)
Mammalia Rhoq 35
  • 93.98 (n)
  • 99.51 (a)
oppossum
(Monodelphis domestica)
Mammalia RHOQ 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOQ 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RHOQ 35
  • 87.64 (n)
  • 96.1 (a)
CHTC10 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RHOQ 36
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rhoq 35
  • 74.96 (n)
  • 90.24 (a)
wufi15a09 35
rhoq 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoL 36
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC42 36
  • 64 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10939 36
  • 55 (a)
ManyToMany
CSA.6319 36
  • 52 (a)
ManyToMany
Species with no ortholog for RHOQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOQ Gene

ENSEMBL:
Gene Tree for RHOQ (if available)
TreeFam:
Gene Tree for RHOQ (if available)

Paralogs for RHOQ Gene

Paralogs for RHOQ Gene

Pseudogenes.org Pseudogenes for RHOQ Gene

genes like me logo Genes that share paralogs with RHOQ: view

Variants for RHOQ Gene

Sequence variations from dbSNP and Humsavar for RHOQ Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1809087 -- 46,566,162(-) TCTCA(C/G)TAGAA intron-variant
rs877876 -- 46,545,895(-) AGAGT(A/G)ATTAC intron-variant
rs1001745 -- 46,547,920(-) AGATC(A/G)GCCTA intron-variant
rs1001746 -- 46,547,460(-) CACTC(C/T)CTCTC intron-variant
rs3053626 -- 46,561,112(+) gtgtg(-/TG)cgcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOQ Gene

Variant ID Type Subtype PubMed ID
dgv1181e1 CNV Complex 17122850
dgv149e55 CNV Loss 17911159
nsv873996 CNV Gain 21882294
esv23599 CNV Loss 19812545
esv2720016 CNV Deletion 23290073
nsv9713 CNV Gain 18304495

Variation tolerance for RHOQ Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RHOQ Gene

Disorders for RHOQ Gene

Relevant External Links for RHOQ

Genetic Association Database (GAD)
RHOQ
Human Genome Epidemiology (HuGE) Navigator
RHOQ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RHOQ

No disorders were found for RHOQ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RHOQ Gene

Publications for RHOQ Gene

  1. Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (PMID: 2108320) Drivas G.T. … D'Eustachio P. (Mol. Cell. Biol. 1990) 2 3 4 67
  2. TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin. (PMID: 19258391) Coisy-Quivy M. … Philips A. (J. Cell. Sci. 2009) 3 23
  3. GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. (PMID: 16950130) Kawase K. … Matsuda M. (Dev. Cell 2006) 3 23
  4. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (PMID: 12687004) Inoue M. … Saltiel A.R. (Nature 2003) 3 23
  5. Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin. (PMID: 12972548) Chunqiu Hou J. … Pessin J.E. (Mol. Biol. Cell 2003) 3 23

Products for RHOQ Gene

Sources for RHOQ Gene

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