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Aliases for RHOQ Gene

Aliases for RHOQ Gene

  • Ras Homolog Family Member Q 2 3
  • ARHQ 3 4 6
  • TC10 3 4 6
  • Ras Homolog Gene Family, Member Q 2 3
  • Ras-Like Protein Family Member 7A 3 4
  • RAS-Like, Family 7, Member A 2 3
  • Ras-Like Protein TC10 3 4
  • RASL7A 3 4
  • Rho-Related GTP-Binding Protein RhoQ 3
  • Epididymis Secretory Protein Li 42 3
  • HEL-S-42 3
  • TC10A 3

External Ids for RHOQ Gene

Previous Symbols for RHOQ Gene

  • RASL7A
  • ARHQ

Summaries for RHOQ Gene

Entrez Gene Summary for RHOQ Gene

  • This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

GeneCards Summary for RHOQ Gene

RHOQ (Ras Homolog Family Member Q) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include GTP binding and profilin binding. An important paralog of this gene is RAC2.

UniProtKB/Swiss-Prot for RHOQ Gene

  • Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

Gene Wiki entry for RHOQ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RHOQ Gene

Genomics for RHOQ Gene

Genomic Location for RHOQ Gene

Start:
46,541,806 bp from pter
End:
46,584,688 bp from pter
Size:
42,883 bases
Orientation:
Plus strand

Genomic View for RHOQ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RHOQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RHOQ Gene

Regulatory Elements for RHOQ Gene

Proteins for RHOQ Gene

  • Protein details for RHOQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17081-RHOQ_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoQ
    Protein Accession:
    P17081
    Secondary Accessions:
    • D6W5A6
    • Q0VGN1
    • Q52LS8
    • Q53SJ1
    • Q6NS39
    • Q6P146
    • Q7Z480

    Protein attributes for RHOQ Gene

    Size:
    205 amino acids
    Molecular mass:
    22659 Da
    Quaternary structure:
    • Interacts with CDC42EP4 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ). Interacts with EXO70 in a GTP-dependent manner. Interacts with GOPC.
    SequenceCaution:
    • Sequence=AAA36547.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAM21123.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RHOQ Gene

neXtProt entry for RHOQ Gene

Proteomics data for RHOQ Gene at MOPED

Post-translational modifications for RHOQ Gene

  • May be post-translationally modified by both palmitoylation and polyisoprenylation
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys169

Other Protein References for RHOQ Gene

No data available for DME Specific Peptides for RHOQ Gene

Domains for RHOQ Gene

UniProtKB/Swiss-Prot:

RHOQ_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • P17081
genes like me logo Genes that share domains with RHOQ: view

No data available for Gene Families for RHOQ Gene

Function for RHOQ Gene

Molecular function for RHOQ Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase
UniProtKB/Swiss-Prot Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

Gene Ontology (GO) - Molecular Function for RHOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 10445846
GO:0005515 protein binding --
GO:0005522 profilin binding IPI 10445846
GO:0005525 GTP binding IEA --
GO:0032427 GBD domain binding IPI 10445846
genes like me logo Genes that share ontologies with RHOQ: view

Phenotypes for RHOQ Gene

GenomeRNAi human phenotypes for RHOQ:
genes like me logo Genes that share phenotypes with RHOQ: view

miRNA for RHOQ Gene

miRTarBase miRNAs that target RHOQ

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RHOQ Gene

Localization for RHOQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for RHOQ Gene

Cytoplasm. Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RHOQ Gene COMPARTMENTS Subcellular localization image for RHOQ gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 4
nucleus 2
endosome 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RHOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005884 actin filament IDA 10445846
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RHOQ: view

Pathways for RHOQ Gene

genes like me logo Genes that share pathways with RHOQ: view

Gene Ontology (GO) - Biological Process for RHOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008152 metabolic process IDA 10445846
GO:0008286 insulin receptor signaling pathway IMP 11309621
genes like me logo Genes that share ontologies with RHOQ: view

Compounds for RHOQ Gene

(3) HMDB Compounds for RHOQ Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(5) Novoseek inferred chemical compound relationships for RHOQ Gene

Compound -log(P) Hits PubMed IDs
gtp 59.8 6
gdp 57.5 1
glucose 49.5 3
lipid 29.4 9
tyrosine 24.4 2
genes like me logo Genes that share compounds with RHOQ: view

Transcripts for RHOQ Gene

Unigene Clusters for RHOQ Gene

Ras homolog family member Q:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RHOQ Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2: -
SP3:

Relevant External Links for RHOQ Gene

GeneLoc Exon Structure for
RHOQ
ECgene alternative splicing isoforms for
RHOQ

Expression for RHOQ Gene

mRNA expression in normal human tissues for RHOQ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RHOQ Gene

This gene is overexpressed in Heart - Left Ventricle (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RHOQ Gene

SOURCE GeneReport for Unigene cluster for RHOQ Gene Hs.709193

genes like me logo Genes that share expressions with RHOQ: view

Orthologs for RHOQ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RHOQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RHOQ 36
  • 99.51 (n)
  • 99.02 (a)
cow
(Bos Taurus)
Mammalia RHOQ 36
  • 96.91 (n)
  • 100 (a)
RHOQ 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RHOQ 36
  • 94.21 (n)
  • 95.81 (a)
RHOQ 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rhoq 36
  • 94.15 (n)
  • 99.51 (a)
Rhoq 16
Rhoq 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RHOQ 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RHOQ 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rhoq 36
  • 93.98 (n)
  • 99.51 (a)
chicken
(Gallus gallus)
Aves CHTC10 37
  • 97 (a)
OneToOne
RHOQ 36
  • 87.64 (n)
  • 96.1 (a)
lizard
(Anolis carolinensis)
Reptilia RHOQ 37
  • 95 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rhoq 36
  • 74.96 (n)
  • 90.24 (a)
rhoq 37
  • 90 (a)
OneToOne
wufi15a09 36
fruit fly
(Drosophila melanogaster)
Insecta RhoL 37
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC42 37
  • 64 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10939 37
  • 55 (a)
ManyToMany
CSA.6319 37
  • 52 (a)
ManyToMany
Species with no ortholog for RHOQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RHOQ Gene

ENSEMBL:
Gene Tree for RHOQ (if available)
TreeFam:
Gene Tree for RHOQ (if available)

Paralogs for RHOQ Gene

Paralogs for RHOQ Gene

Pseudogenes.org Pseudogenes for RHOQ Gene

genes like me logo Genes that share paralogs with RHOQ: view

Variants for RHOQ Gene

Sequence variations from dbSNP and Humsavar for RHOQ Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs877876 -- 46,545,895(-) AGAGT(A/G)ATTAC intron-variant
rs1001745 -- 46,547,920(-) AGATC(A/G)GCCTA intron-variant
rs1001746 -- 46,547,460(-) CACTC(C/T)CTCTC intron-variant
rs1451157 -- 46,555,128(-) AAGCT(C/T)TCGCC intron-variant
rs1809087 -- 46,566,162(-) TCTCA(C/G)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RHOQ Gene

Variant ID Type Subtype PubMed ID
dgv1181e1 CNV Complex 17122850
dgv149e55 CNV Loss 17911159
nsv873996 CNV Gain 21882294
esv23599 CNV Loss 19812545
esv2720016 CNV Deletion 23290073
nsv9713 CNV Gain 18304495

Relevant External Links for RHOQ Gene

HapMap Linkage Disequilibrium report
RHOQ

Disorders for RHOQ Gene

Relevant External Links for RHOQ

Genetic Association Database (GAD)
RHOQ
Human Genome Epidemiology (HuGE) Navigator
RHOQ
genes like me logo Genes that share disorders with RHOQ: view

No data available for UniProtKB/Swiss-Prot for RHOQ Gene

Publications for RHOQ Gene

  1. PIST: a novel PDZ/coiled-coil domain binding partner for the rho- family GTPase TC10. (PMID: 11162552) Neudauer C.L. … Macara I.G. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (PMID: 2108320) Drivas G.T. … D'Eustachio P. (Mol. Cell. Biol. 1990) 2 3 4
  3. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PMID: 10490598) Joberty G. … Macara I.G. (Mol. Cell. Biol. 1999) 3 4
  4. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PMID: 10934474) Joberty G. … Macara I.G. (Nat. Cell Biol. 2000) 3 4
  5. TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin. (PMID: 19258391) Coisy-Quivy M. … Philips A. (J. Cell. Sci. 2009) 3 23

Products for RHOQ Gene

  • Addgene plasmids for RHOQ

Sources for RHOQ Gene

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