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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RHOQ Gene

protein-coding   GIFtS: 63
GCID: GC02P046768

ras homolog family member Q

(Previous names: RAS-like, family 7, member A, ras homolog gene family,...)
(Previous symbols: RASL7A, ARHQ)
 Explore 8 diseases affiliated with
RHOQ via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RHOQ    

Aliases
for RHOQ gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ras Homolog Family Member Q1 2     RAS-Like, Family 7, Member A1 2
ARHQ1 2 3 5     Ras-Like Protein Family Member 7A2 3
TC101 2 3 5     Ras-Like Protein TC102 3
RASL7A1 2 3     TC10A2
Ras Homolog Gene Family, Member Q1 2     Rho-Related GTP-Binding Protein RhoQ2

External Ids:    HGNC: 177361   Entrez Gene: 234332   Ensembl: ENSG000001197297   OMIM: 6058575   UniProtKB: P170813   

Export aliases for RHOQ gene to outside databases

Previous GC identifers: GC02P046745 GC02P046682 GC02P046623 GC02P046507


Summaries
for RHOQ gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RHOQ:
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active
GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote
reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an
important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of
the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the
signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and
14. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: RHOQ_HUMAN, P17081
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound
state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial
cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin,
actin-rich surface projections called filopodia

Gene Wiki entry for RHOQ


Genomic Views
for RHOQ gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RHOQ gene promoter:
         Pbx1a   HTF   STAT5A   Ik-3   AP-2gamma   C/EBPalpha   Max   Ik-2   LyF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RHOQ promoter sequence
   Search SABiosciences Chromatin IP Primers for RHOQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RHOQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21

RHOQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RHOQ gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P046768:  view genomic region     (about GC identifiers)

Start:
 46,768,945 bp from pter      End:
 46,811,827 bp from pter
Size:
 42,883 bases      Orientation:
 plus strand

Proteins
for RHOQ gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RHOQ_HUMAN, P17081 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoQ precursor  
Size: 205 amino acids; 22659 Da
Subunit: Interacts with CDC42EP4 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP (By similarity). Interacts
with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a
quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein
(PRKCI or PRKCZ). Interacts with EXO70 in a GTP-dependent manner. Interacts with GOPC
Subcellular location: Cytoplasm. Cell membrane; Lipid-anchor
Sequence caution: Sequence=AAA36547.1; Type=Erroneous initiation; Sequence=AAM21123.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for RHOQ:
2ATX (3D)    
Secondary accessions: D6W5A6 Q0VGN1 Q52LS8 Q53SJ1 Q6NS39 Q6P146 Q7Z480

Explore the universe of human proteins at neXtProt for RHOQ: NX_P17081

Post-translational modifications:

  • May be post-translationally modified by both palmitoylation and polyisoprenylation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17081

    • RHOQ Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036381.2  
    ENSEMBL proteins: 
     ENSP00000238738   ENSP00000393140   ENSP00000428624   ENSP00000428006   ENSP00000429003  
    Reactome Protein details: P17081
    Human Recombinant Protein Products: 
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    Novus Biologicals RHOQ Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RHOQ

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005884actin filament IDA10445846
    GO:0005886plasma membrane TAS--
    GO:0045121membrane raft IEA--


    RHOQ for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RHOQ

    Protein Domains /
    Families
    for RHOQ gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RHOQ for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase

    Graphical View of Domain Structure for InterPro Entry P17081

    ProtoNet protein and cluster: P17081

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RHOQ_HUMAN, P17081
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Function
    for RHOQ gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RHOQ_HUMAN, P17081
    Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound
    state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial
    cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin,
    actin-rich surface projections called filopodia
    Enzyme regulation: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for
    free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation
    inhibitors which inhibit the dissociation of the nucleotide from the GTPase

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RHOQ
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOQ (see all 86):
    hsa-miR-124* hsa-miR-579 hsa-miR-548j hsa-miR-100* hsa-miR-485-3p hsa-miR-134 hsa-miR-3653 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmid: RHOQ 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RHOQ

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA10445846
    GO:0005515protein binding ----
    GO:0005522profilin binding IPI10445846
    GO:0005525GTP binding IEA--
    GO:0032427GBD domain binding IPI10445846


    RHOQ for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RHOQ:
     Decreased focal adhesion (FA)  


    Pathways & Interactions
    for RHOQ gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1COPII (Coat Protein 2) Mediated Vesicle Transport
    		Normal wtCFTR traffic / ER-to-Golgi 0.36
    		Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    2Cell death signalling via NRAGE, NRIF and NADE
    		Rho GTPase cycle0.25
    		Signaling by Rho GTPases0.25
    3Insulin Signaling
    		Insulin Signaling1.00
    4Insulin Pathway
    		Insulin Pathway1.00
    5Insulin-mediated glucose transport
    		Insulin-mediated glucose transport1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for RHOQ
        Adipocytokines & Insulin Signaling


    3 GeneGo (Thomson Reuters) Pathways for RHOQ
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Normal wtCFTR traffic / ER-to-Golgi

    3 BioSystems Pathways for RHOQ 
        Insulin Signaling
    Insulin-mediated glucose transport
    Insulin Pathway

    3        Reactome Pathways for RHOQ
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle


    1         Kegg Pathway  (Kegg details for RHOQ):
        Insulin signaling pathway


    RHOQ for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RHOQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/158 Interacting proteins for RHOQ (P170813 ENSP000002387384) via UniProtKB, MINT, STRING, and/or I2D (see all 158)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42EP1Q005873, ENSP000002490144I2D: score=4 STRING: ENSP00000249014
    CDC42EP3Q9UKI23, ENSP000002953244I2D: score=4 STRING: ENSP00000295324
    CDC42EP2O146133, ENSP000002792494I2D: score=3 STRING: ENSP00000279249
    PFN1P077373, ENSP000002256554I2D: score=3 STRING: ENSP00000225655
    CDC42BPAQ5VT253, ENSP000003557314I2D: score=2 STRING: ENSP00000355731
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA10445846
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0008286insulin receptor signaling pathway IMP11309621
    GO:0008360regulation of cell shape IEA--
    GO:0030866cortical actin cytoskeleton organization IMP11821390


    RHOQ for ontologies           About GeneDecksing



    Drugs & Compounds
    for RHOQ gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RHOQ for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RHOQ

    3 HMDB Compounds for RHOQ    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    5 Novoseek chemical compound relationships for RHOQ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 59.8 9 16950130 (3), 11162552 (1), 12436329 (1), 10967094 (1)
    gdp 57.5 1 10967094 (1)
    glucose 49.5 3 16472699 (2), 12242347 (1)
    lipid 29.4 13 11502760 (3), 16472699 (2), 12972548 (2), 12436329 (1) (see all 5)
    tyrosine 24.4 3 16472699 (1), 20071559 (1)

    Search CenterWatch for drugs/clinical trials and news about RHOQ 

    Transcripts
    for RHOQ gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RHOQ gene: 
    NM_012249.3  

    Unigene Cluster for RHOQ:

    Ras homolog family member Q
    Hs.709193  [show with all ESTs]
    Unigene Representative Sequence: NM_012249
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465198 ENST00000238738(uc002rva.3) ENST00000432183 ENST00000489471
    ENST00000482449 ENST00000473428 ENST00000494370 ENST00000489448

    miRNA
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    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate RHOQ (see all 86):
    hsa-miR-124* hsa-miR-579 hsa-miR-548j hsa-miR-100* hsa-miR-485-3p hsa-miR-134 hsa-miR-3653 hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmid: RHOQ 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF498976.1 AK095329.1 BC013135.1 BC056154.1 BC065291.1 BC070485.1 BC093805.1 BC101806.1 
    M31470.1 

    24/32 DOTS entries (see all 32):

    DT.101964554  DT.95219874  DT.449747  DT.95219908  DT.121012490  DT.100884833  DT.121012465  DT.312837 
    DT.120981385  DT.92451558  DT.97777552  DT.100884834  DT.100884850  DT.100884868  DT.120769710  DT.121012416 
    DT.95219876  DT.100679258  DT.100884832  DT.100884864  DT.121012411  DT.121012462  DT.121012520  DT.100038200 

    24/407 AceView cDNA sequences (see all 407):

    AA809895 AW272245 BG231991 BM697552 BF003074 AW866607 AI090980 AA857506 
    BE328391 CA843293 BM972822 BM667696 BU620003 AI523244 R82731 BF436058 
    CN480025 NM_012249 N56895 BQ215454 AI824554 AI290305 D31543 CA419199 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RHOQ    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
    SP1:                                    
    SP2:        -                           
    SP3:                                    


    ECgene alternative splicing isoforms for RHOQ

    Expression
    for RHOQ gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RHOQ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTAACTAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RHOQ expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RHOQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RHOQ

    SOURCE GeneReport for Unigene cluster: Hs.709193
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    In Situ
    Assay Products:     
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    Orthologs
    for RHOQ gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RHOQ gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RHOQ1 ras homolog gene family, member Q 87.64(n)
    96.1(a)    		   395114  NM_204461.1  NP_989792.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RHOQ6
    		 --
    		 94(a)
    		 1 ↔ 1
    		 2(142741899-142784112)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi15a092 wufi15a09 77.16(n)   327510  BC045850.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 45(a)
    		 possible ortholog
    		 GroupUn.2917(49-952)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATROP66
    ROP16
    (see all 11)    		 Rac-like GTP-binding protein ARAC11
    (see all 11)    		 53(a)
    51(a)
    (see all 11)    		 many ↔ many
    many ↔ many
    (see all 11)    		 4(16672192-16674771)
    3(19042887-19044372)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 ras-related protein, putative, expressed
    (see all 9)    		 51(a)
    51(a)
    (see all 9)    		 many ↔ many
    many ↔ many
    (see all 9)    		 2(12324543-12326740)
    2(35874978-35879805)


    ENSEMBL Gene Tree for RHOQ (if available)
    TreeFam Gene Tree for RHOQ (if available) 

    Paralogs
    for RHOQ gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RHOQ gene
    RHOH2  RHOBTB12  RHOV2  RHOG2  RHOU2  RHOBTB22  RAC12  RAC22  
    CDC422  RHOJ2  RAC32  
    18/39 SIMAP similar genes for RHOQ using alignment to 6 protein entries:     RHOQ_HUMAN (see all proteins) (see all similar genes):
    RHOJ    CDC42    RAC2    RHOA    RHOC    RAC3
    RHOU    RAC1    ARHG    RHOG    RHOF    RHOH
    RHOB    RHOV    RAB10    RHOD    ARHA    ARHE

    RHOQ for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RHOQ
    PGOHUM00000248161 PGOHUM00000240296 PGOHUM00000240942


    Genomic Variants
    for RHOQ gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/618 NCBI SNPs in RHOQ are shown (see all 618)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1134467661,2
    		C,--46506601(+) GAACAC/TTGGGG 1 -- nc-transcript-variant0--------
    rs621347371,2
    		--46506647(+) GGGAGC/TCCAGG 1 -- nc-transcript-variant1Minor allele frequency- T:0.50NA 2
    rs791209561,2
    		--46507097(+) AAATAC/TGCATG 1 -- us2k10--------
    rs787952421,2
    		F,--46508187(+) CTTTGC/GCGGTT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1139618211,2
    		--46508607(+) TAAGCG/CCCCCC 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs2020564811,2
    		--46767872(+) CTGAC-/AGGGGG 2 -- us2k1 int10--------
    rs1906691321,2
    		--46768040(+) ATCAGC/TTCCCC 2 -- us2k1 int10--------
    rs1924016621,2
    		--46768146(+) CAAGGA/TAACAC 2 -- us2k1 int10--------
    rs1445539571,2
    		--46768161(+) AACCA-/GGGTCA 2 -- us2k1 int10--------
    rs75684171,2
    		C,F,H,--46768363(+) GACCTT/GAAGGC 2 -- int1 us2k16Minor allele frequency- G:0.01NS EA NA 424

    HapMap Linkage Disequilibrium report for RHOQ (46768945 - 46811827 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for RHOQ
         4 CNVs: 8944 3354 30941 78531
         1 Indel: 73481

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    Disorders / Diseases
    for RHOQ gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RHOQ for disorders           About GeneDecksing

    OMIM gene information: 605857    OMIM disorders: --

    8 diseases for RHOQ:    About MalaCards
    wiskott-aldrich syndrome    myotonic dystrophy    insulin resistance    cystic fibrosis
    teratocarcinoma    fibrosis    cholesterol    sepsis

    Human Genome Epidemiology (HuGE) Navigator: RHOQ (3 documents)

    Export disorders for RHOQ gene to outside databases

    Publications
    for RHOQ gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RHOQ gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with RHOQ)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. (PubMed id 2108320)1, 2, 3 Drivas G.T.... D'Eustachio P. (1990)
    2. PIST: a novel PDZ/coiled-coil domain binding partner for the rho- family GTPase TC10. (PubMed id 11162552)1, 2, 9 Neudauer C.L.... Macara I.G. (2001)
    3. Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10. (PubMed id 15546864)1, 2 Cheng J.... Guggino W.B. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    6. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PubMed id 10934474)1, 2 Joberty G.... Macara I.G. (2000)
    7. The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. (PubMed id 10490598)1, 2 Joberty G.... Macara I.G. (1999)
    8. Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth. (PubMed id 10445846)1, 9 Murphy G.A....Rush M.G. (1999)
    9. Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin. (PubMed id 12972548)1, 9 Chunqiu Hou J. and Pessin J.E. (2003)
    10. TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin. (PubMed id 19258391)1, 9 Coisy-Quivy M....Philips A. (2009)

    External Searches for RHOQ gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RHOQ gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23433 HGNC: 17736 AceView: RHOQ Ensembl:ENSG00000119729 euGenes: HUgn23433
    ECgene: RHOQ Kegg: 23433 H-InvDB: RHOQ

    Other Databases showing RHOQ gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RHOQ gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RHOQ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RHOQ Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RHOQ gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RHOQ gene:
    Search GeneIP for patents involving RHOQ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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